CN117815340A - Traditional Chinese medicine composition for reducing blood sugar and preparation method thereof - Google Patents
Traditional Chinese medicine composition for reducing blood sugar and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for reducing blood sugar and a preparation method thereof, wherein the traditional Chinese medicine composition comprises a main material and an auxiliary material, and the main material and the auxiliary material are prepared from the following traditional Chinese medicine materials in parts by weight: the main materials comprise: 30 parts of astragalus membranaceus, 35 parts of cortex lycii radicis, 25 parts of medlar, 25 parts of ginseng, 30 parts of schisandra chinensis, 20 parts of coptis chinensis, 15 parts of mulberry leaves, 15 parts of platycodon grandiflorum, 25 parts of polygonatum odoratum and 10 parts of liquorice; the auxiliary materials comprise: the invention relates to the technical field of hypoglycemic drugs, and discloses a traditional Chinese medicine composition for reducing blood sugar, which has good auxiliary hypoglycemic effect, contains no chemical synthetic drugs, no hormone and no drug burden on a body, and comprises 20-40 parts of kudzuvine root, 15-35 parts of hawthorn, 15-20 parts of poria cocos, 15-35 parts of bighead atractylodes rhizome, 15-35 parts of rhizoma atractylodis, 0-40 parts of rhizoma polygonati, 0-30 parts of catharanthus roseus, 10-30 parts of Chinese yam, 20-25 parts of wild chrysanthemum, 10-30 parts of selfheal, 20-40 parts of rehmannia, 30-55 parts of corn silk, 25-35 parts of red sage root, 10-15 parts of honeysuckle stem, 0-45 parts of rhizoma anemarrhenae, 0-45 parts of radix trichosanthis and 0-45 parts of dwarf lilyturf tuber.
Description
Technical Field
The invention relates to the technical field of hypoglycemic drugs, in particular to a traditional Chinese medicine composition for reducing blood sugar and a preparation method thereof.
Background
Hyperglycemia refers to a medical condition in which excess glucose accumulates in plasma, and when the blood glucose level is higher than the normal range, it is referred to as hyperglycemia, which generally means that the blood glucose level is higher than 11.1mmol/L (200 mg/dl), but symptoms are not obvious until the blood glucose level rises to 15-20mmol/L (250-300 mg/dl). Under normal conditions, blood glucose exceeding 5.6-7mmol/L (100-126 mg/dl) is considered slightly hyperglycemic, whereas diabetes is generally seen with exceeding 7 mmol/L.
There are two factors that lead to diabetes, one is a genetic factor and the other is an environmental factor.
Genetic factors are the involvement of multiple DNA sites in the onset of type 1 diabetes or the well-defined genetic mutations of type 2 diabetes, such as insulin genes, insulin receptor genes, glucokinase genes, mitochondrial genes, etc.
The environmental factors are overeating, obesity caused by reduced physical activity is the most important environmental factor for type 2 diabetes; the traditional Chinese medicine composition for reducing blood sugar is used for reducing blood sugar under the condition. The existing hypoglycemic drugs on the market are already mature products, and have good auxiliary hypoglycemic effects in combination with sports and reasonable diet. In practice, however, hyperglycemia does not occur alone in patients with diabetes, and other related disorders are often accompanied, for example, patients with diabetes are also accompanied by problems of hypertension and hyperlipidemia; or patients suffering from diabetes mellitus usually suffer from obesity due to overeating and hypokinesia (more serious diabetics can be accompanied by symptoms of more than three, less and possibly lighter weight, the obesity is common but not absolute), and the patients are in habit of overeating, have greasy and high sugar; some problems occur in the excretion of people with hyperglycemia, polydipsia and diuresis are marked symptoms, and most patients are accompanied by fewer constipation or more diarrhea; therefore, the traditional Chinese medicine composition for reducing blood sugar has the effect of reducing blood sugar, and can be used for carrying out good auxiliary treatment on other diseases accompanied by hyperglycemia.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition for reducing blood sugar and a preparation method thereof, which are mainly used for reducing blood sugar of patients with hyperglycemia, and can also solve the problem of the auxiliary treatment of other diseases such as hyperlipidemia or hypertension of the patients with hyperglycemia which the traditional blood sugar reducing prescription does not have.
In order to achieve the above purpose, the invention is realized by the following technical scheme: the traditional Chinese medicine composition comprises a main material and an auxiliary material, wherein the main material and the auxiliary material are prepared from the following traditional Chinese medicinal materials in parts by weight:
the main materials comprise: 30 parts of astragalus membranaceus, 35 parts of cortex lycii radicis, 25 parts of medlar, 25 parts of ginseng, 30 parts of schisandra chinensis, 20 parts of coptis chinensis, 15 parts of mulberry leaves, 15 parts of platycodon grandiflorum, 25 parts of polygonatum odoratum and 10 parts of liquorice;
the auxiliary materials comprise: 20-40 parts of kudzuvine root, 15-35 parts of hawthorn, 15-20 parts of poria cocos, 15-35 parts of bighead atractylodes rhizome, 15-35 parts of rhizoma atractylodis, 0-40 parts of rhizoma polygonati, 0-30 parts of catharanthus roseus, 10-30 parts of Chinese yam, 20-25 parts of wild chrysanthemum, 10-30 parts of selfheal, 20-40 parts of rehmannia root, 30-55 parts of corn silk, 25-35 parts of red sage root, 10-15 parts of honeysuckle stem, 0-45 parts of rhizoma anemarrhenae, 0-45 parts of radix trichosanthis, 0-45 parts of dwarf lilyturf tuber, 0-35 parts of cassia seed, 10-35 parts of cherokee rose fruit, 0-40 parts of cistanche and 10-40 parts of glossy privet fruit.
Preferably, the preparation method comprises the following steps:
s1: weighing main materials, mixing the main materials, decocting in water for 1 hr, filtering to remove residue, decocting with slow fire for 1 hr, filtering to remove residue, adding hot water, decocting with slow fire until the residue is completely filtered, concentrating the medicinal liquid, cooling to obtain extract, oven drying, and pulverizing to obtain main material powder;
s2: weighing radix Puerariae, fructus crataegi, poria, atractylodis rhizoma, rhizoma Atractylodis, rhizoma Dioscoreae, flos Chrysanthemi Indici, prunellae Spica, rehmanniae radix, stigma Maydis, saviae Miltiorrhizae radix, caulis Lonicerae and fructus Rosae Laevigatae in adjuvant, soaking in ethanol for 1-2 hr, taking out residues to obtain extract of the adjuvant, concentrating the extract of the adjuvant into extract, drying the extract, and pulverizing to obtain adjuvant powder;
s3: mixing the main material powder and the auxiliary material powder uniformly, and sterilizing to obtain the capsule medicine product.
Preferably, the traditional Chinese medicinal materials of rhizoma polygonati, catharanthus roseus, rhizoma anemarrhenae, radix trichosanthis, radix ophiopogonis, semen cassiae, cistanche deserticola and glossy privet fruit in the auxiliary materials are respectively and independently weighed, one or a plurality of traditional Chinese medicinal materials are mixed, ethanol is added for soaking for 1-1.5 hours, then the dregs are fished out to obtain a new auxiliary material extract, the new auxiliary material extract is concentrated into an extract, and the extract is dried and crushed to obtain new auxiliary material powder.
Preferably, the new auxiliary material powder and the auxiliary material powder are uniformly mixed to obtain the composite powder.
Preferably, the composite powder and the main material powder are uniformly mixed, and the capsule medicine product is prepared after sterilization and disinfection.
Advantageous effects
The invention provides a traditional Chinese medicine composition for reducing blood sugar and a preparation method thereof, and the traditional Chinese medicine composition has the following beneficial effects:
1. the traditional Chinese medicine composition for reducing blood sugar has the medicines such as astragalus, cortex lycii radicis, medlar, ginseng, shizandra berry, coptis chinensis, mulberry leaf, platycodon grandiflorum, polygonatum odoratum and the like, has good auxiliary effect of reducing blood sugar, and has the effects of promoting the production of body fluid to quench thirst, wherein the traditional Chinese medicine composition does not contain chemical synthetic medicines or hormone, and does not cause medicine burden to the body.
2. Meanwhile, the traditional Chinese medicine composition contains the traditional Chinese medicine components of kudzuvine root, hawthorn, poria cocos, bighead atractylodes rhizome, rhizoma atractylodis, chinese yam, wild chrysanthemum, selfheal, rehmannia root, corn silk, red-rooted salvia root, honeysuckle stem and cherokee rose fruit, can achieve the effects of reducing blood fat and blood pressure, and has the effect of assisting in treating other diseases for patients suffering from hyperglycemia.
3. In the formula of the traditional Chinese medicine composition, one or more of the traditional Chinese medicine materials are used in a matching way according to the condition that patients are actually accompanied with symptoms: rhizoma Polygonati, herba Catharanthi rosei, rhizoma anemarrhenae, radix Trichosanthis, radix Ophiopogonis, semen Cassiae, herba cistanches, and fructus Ligustri Lucidi, which can be mixed with auxiliary material powder to obtain composite powder, thereby increasing other medicinal effects of the traditional Chinese medicinal composition for reducing blood sugar, such as improving appetite of patients, assisting in reducing binge eating, and reducing sugar intake; the composition can be used for treating constipation and diarrhea.
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Without any means for
Detailed Description
The technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The invention provides a technical scheme that: the traditional Chinese medicine composition comprises a main material and an auxiliary material, wherein the main material and the auxiliary material are prepared from the following traditional Chinese medicinal materials in parts by weight:
the main materials comprise: 30 parts of astragalus membranaceus, 35 parts of cortex lycii radicis, 25 parts of medlar, 25 parts of ginseng, 30 parts of schisandra chinensis, 20 parts of coptis chinensis, 15 parts of mulberry leaves, 15 parts of platycodon grandiflorum, 25 parts of polygonatum odoratum and 10 parts of liquorice;
the auxiliary materials comprise: 20-40 parts of kudzuvine root, 15-35 parts of hawthorn, 15-20 parts of poria cocos, 15-35 parts of bighead atractylodes rhizome, 15-35 parts of rhizoma atractylodis, 0-40 parts of rhizoma polygonati, 0-30 parts of catharanthus roseus, 10-30 parts of Chinese yam, 20-25 parts of wild chrysanthemum, 10-30 parts of selfheal, 20-40 parts of rehmannia root, 30-55 parts of corn silk, 25-35 parts of red sage root, 10-15 parts of honeysuckle stem, 0-45 parts of rhizoma anemarrhenae, 0-45 parts of radix trichosanthis, 0-45 parts of dwarf lilyturf tuber, 0-35 parts of cassia seed, 10-35 parts of cherokee rose fruit, 0-40 parts of cistanche and 10-40 parts of glossy privet fruit.
Among the auxiliary materials:
rhizoma Polygonati, herba Catharanthi rosei, rhizoma anemarrhenae, radix Trichosanthis, radix Ophiopogonis, semen Cassiae, and herba cistanches can be used in an amount of 0 parts, or one or more of them can be used in an amount of 0 parts according to the accompanying symptoms of patients.
If patients constipation, herba cistanches, semen Cassiae, radix Ophiopogonis, and rhizoma anemarrhenae can be added to relieve constipation.
The kudzuvine root, the coptis chinensis and the shizandra berry also have the efficacy of treating diarrhea.
Further, the preparation method comprises the following steps:
s1: weighing main materials, mixing the main materials, decocting in water for 1 hr, filtering to remove residue, decocting with slow fire for 1 hr, filtering to remove residue, adding hot water, decocting with slow fire until the residue is completely filtered, concentrating the medicinal liquid, cooling to obtain extract, oven drying, and pulverizing to obtain main material powder;
s2: weighing radix Puerariae, fructus crataegi, poria, atractylodis rhizoma, rhizoma Atractylodis, rhizoma Dioscoreae, flos Chrysanthemi Indici, prunellae Spica, rehmanniae radix, stigma Maydis, saviae Miltiorrhizae radix, caulis Lonicerae and fructus Rosae Laevigatae in adjuvant, soaking in ethanol for 1-2 hr, taking out residues to obtain extract of the adjuvant, concentrating the extract of the adjuvant into extract, drying the extract, and pulverizing to obtain adjuvant powder;
s3: mixing the main material powder and the auxiliary material powder uniformly, and sterilizing to obtain the capsule medicine product.
The processing and processing of the traditional Chinese medicinal materials belongs to the existing mature technology, is common knowledge in the field of traditional Chinese medicines, further does not describe the processing process, time and duration of each medicinal material in detail, filtering the dregs, concentrating, pulverizing and mixing the medicinal liquid, is common knowledge in the field of traditional Chinese medicinal material processing, and is not the key design of the invention, so the detailed process and steps of pharmacy are not described in detail, and the traditional medicinal material processing method and steps are only used for processing the traditional Chinese medicinal materials.
Further, the traditional Chinese medicinal materials of rhizoma polygonati, catharanthus roseus, rhizoma anemarrhenae, radix trichosanthis, radix ophiopogonis, semen cassiae, cistanche deserticola and glossy privet fruit in the auxiliary materials are respectively and independently weighed, one or a plurality of traditional Chinese medicinal materials are mixed, ethanol is added for soaking for 1-1.5 hours, then the dregs are fished out to obtain a new auxiliary material extract, the new auxiliary material extract is concentrated into an extract, and the extract is dried and crushed to obtain new auxiliary material powder.
Further, the new auxiliary material powder and the auxiliary material powder are uniformly mixed to obtain the composite powder.
Further, the composite powder and the main material powder are uniformly mixed, and the capsule medicine product is prepared after sterilization and disinfection.
The following table shows the hyperglycemia experimental data of three groups of 30 mice, and in the experimental detection of diabetes, the feeding of the mice belongs to the mature technology, the mice are fed with Gao Tang high-fat feed for several weeks to reach the hyperglycemia experimental standard, and the culture process belongs to the common general knowledge of the laboratory, so the feeding process and the operation flow are not described in detail.
The traditional Chinese medicine hypoglycemic drugs are taken by the laboratory mice taking the hypoglycemic drug group.
The experiment is comparative data of a simple experiment mouse after taking the medicine, the blood sugar concentration of the experiment mouse is difficult to be quickly reduced without taking the medicine, and the blood sugar reducing effect of the experiment mouse taking the traditional Chinese medicine blood sugar reducing medicine and the blood sugar reducing medicine can be achieved.
The reason that the blood sugar concentration of the experimental mice taking the formula group is slightly lower than that of the experimental mice taking the hypoglycemic agent group is that the auxiliary materials play a role in improving appetite, regulating spleen and stomach, reducing sugar intake and further playing a role in assisting in reducing blood sugar.
The following table shows the total weight of food remaining for each group of rats.
The experimental data are recorded on simple feeding data of the experimental mice of each group, the data have small experimental errors and belong to normal phenomena, the method is used for weighing all the residual feeds of the whole group, because each experimental mouse individual has differences, the weight of each experimental mouse and the weight of the residual feeds are not weighed in detail, the total amount of the residual feeds is detected by the whole group at the same time, and the experimental errors are reduced.
The total weight of the residual feed is weighed, so that the consumption of the feed of the experimental mice taking the formula is lower, and the formula is used for reducing blood sugar from two aspects simultaneously, one is normal medicine for reducing blood sugar, and the other is for controlling the blood sugar rise by improving the appetite to regulate the spleen and stomach and reducing the intake of food.
By means of the technical personnel in the field, the traditional Chinese medicinal materials in the scheme are processed, the specific processing and the operation sequence should be referred to the following working principle, the detailed connection means are known in the field, and the working principle and the process are mainly described below.
Example 1: a traditional Chinese medicine composition for reducing blood sugar is composed of the following traditional Chinese medicinal materials:
the main materials comprise: 30 parts of astragalus membranaceus, 35 parts of cortex lycii radicis, 25 parts of medlar, 25 parts of ginseng, 30 parts of schisandra chinensis, 20 parts of coptis chinensis, 15 parts of mulberry leaves, 15 parts of platycodon grandiflorum, 25 parts of polygonatum odoratum and 10 parts of liquorice;
the auxiliary materials comprise: 20 parts of kudzuvine root, 15 parts of hawthorn, 15 parts of poria cocos, 15 parts of bighead atractylodes rhizome, 15 parts of rhizoma atractylodis, 10 parts of Chinese yam, 20 parts of wild chrysanthemum flower, 10 parts of selfheal, 20 parts of rehmannia root, 55 parts of corn silk, 25 parts of red sage root, 10 parts of honeysuckle stem, 10 parts of cherokee rose fruit and 10 parts of glossy privet fruit.
The preparation method of the traditional Chinese medicine composition for reducing blood sugar comprises the following steps: weighing main materials, mixing the main materials, decocting in water for 1 hour, filtering out residues, then decocting with slow fire for 1 hour, continuously filtering out residues, then adding hot water, continuously decocting with slow fire until residues are filtered completely, concentrating and cooling the liquid medicine to form extract, finally drying and crushing to prepare main material powder, weighing auxiliary materials, adding ethanol for soaking for 1-2 hours, then taking out residues to obtain auxiliary material extract, concentrating the auxiliary material extract into extract, drying the extract, crushing to obtain auxiliary material powder, uniformly mixing the main material powder and the auxiliary material powder, and sterilizing to obtain the capsule medicine product.
The administration method of the traditional Chinese medicine composition comprises the following steps: one dose is taken a day, and 20 days is a treatment course.
Example 2: a traditional Chinese medicine composition for reducing blood sugar is composed of the following traditional Chinese medicinal materials:
the main materials comprise: 30 parts of astragalus membranaceus, 35 parts of cortex lycii radicis, 25 parts of medlar, 25 parts of ginseng, 30 parts of schisandra chinensis, 20 parts of coptis chinensis, 15 parts of mulberry leaves, 15 parts of platycodon grandiflorum, 25 parts of polygonatum odoratum and 10 parts of liquorice;
the auxiliary materials comprise: 20 parts of kudzuvine root, 15 parts of hawthorn, 15 parts of poria cocos, 15 parts of bighead atractylodes rhizome, 15 parts of rhizoma atractylodis, 20 parts of rhizoma polygonati, 15 parts of catharanthus roseus, 10 parts of Chinese yam, 20 parts of wild chrysanthemum flower, 10 parts of selfheal, 20 parts of rehmannia root, 55 parts of corn silk, 25 parts of red-rooted salvia root, 10 parts of honeysuckle stem, 25 parts of rhizoma anemarrhenae, 25 parts of radix trichosanthis, 25 parts of dwarf lilyturf tuber, 20 parts of cassia seed, 10-35 parts of cherokee rose fruit, 20 parts of cistanche deserticola and 10 parts of glossy privet fruit.
The preparation method of the traditional Chinese medicine composition for reducing blood sugar comprises the following steps: weighing main materials, mixing the main materials, decocting in water for 1 hour, filtering out dregs, then decocting with slow fire for 1 hour, continuously filtering out dregs, then adding hot water, continuously decocting with slow fire until dregs are filtered completely, concentrating and cooling liquid medicine to form extract, finally drying and crushing to prepare main material powder, weighing auxiliary materials, adding ethanol to soak for 1-2 hours, fishing out dregs to obtain auxiliary material extract, concentrating the auxiliary material extract into extract, drying and crushing the extract to obtain auxiliary material powder, respectively weighing Chinese medicinal materials of rhizoma polygonati, vinca, rhizoma anemarrhenae, radix trichosanthis, dwarf lilyturf tuber, semen cassiae, cistanche and glossy privet fruit in the auxiliary material, adding ethanol to soak for 1-1.5 hours, fishing out dregs to obtain new auxiliary material extract, concentrating the new auxiliary material extract into extract, crushing the extract after drying to obtain new auxiliary material powder, uniformly mixing the new auxiliary material powder and the auxiliary material powder, uniformly mixing the composite powder and the main material powder, and sterilizing to obtain a capsule medicine product.
The formula is used for patients with constipation, and the administration method of the traditional Chinese medicine composition comprises the following steps: one dose per day, 7 days as a treatment course, and the same treatment course as the treatment course of the hypoglycemic Chinese medicinal composition in example 1 after the disappearance of constipation symptoms.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation. The term "comprising" an element defined by the term "comprising" does not exclude the presence of other identical elements in a process, method, article or apparatus that comprises the element.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. The traditional Chinese medicine composition for reducing blood sugar and the preparation method thereof are characterized by comprising main materials and auxiliary materials, wherein the main materials and the auxiliary materials are prepared from the following traditional Chinese medicine materials in parts by weight:
the main materials comprise: 30 parts of astragalus membranaceus, 35 parts of cortex lycii radicis, 25 parts of medlar, 25 parts of ginseng, 30 parts of schisandra chinensis, 20 parts of coptis chinensis, 15 parts of mulberry leaves, 15 parts of platycodon grandiflorum, 25 parts of polygonatum odoratum and 10 parts of liquorice;
the auxiliary materials comprise: 20-40 parts of kudzuvine root, 15-35 parts of hawthorn, 15-20 parts of poria cocos, 15-35 parts of bighead atractylodes rhizome, 15-35 parts of rhizoma atractylodis, 0-40 parts of rhizoma polygonati, 0-30 parts of catharanthus roseus, 10-30 parts of Chinese yam, 20-25 parts of wild chrysanthemum, 10-30 parts of selfheal, 20-40 parts of rehmannia root, 30-55 parts of corn silk, 25-35 parts of red sage root, 10-15 parts of honeysuckle stem, 0-45 parts of rhizoma anemarrhenae, 0-45 parts of radix trichosanthis, 0-45 parts of dwarf lilyturf tuber, 0-35 parts of cassia seed, 10-35 parts of cherokee rose fruit, 0-40 parts of cistanche and 10-40 parts of glossy privet fruit.
2. The hypoglycemic Chinese medicinal composition and the preparation method thereof according to claim 1, wherein the preparation method comprises the following steps of:
s1: weighing main materials, mixing the main materials, decocting in water for 1 hr, filtering to remove residue, decocting with slow fire for 1 hr, filtering to remove residue, adding hot water, decocting with slow fire until the residue is completely filtered, concentrating the medicinal liquid, cooling to obtain extract, oven drying, and pulverizing to obtain main material powder;
s2: weighing radix Puerariae, fructus crataegi, poria, atractylodis rhizoma, rhizoma Atractylodis, rhizoma Dioscoreae, flos Chrysanthemi Indici, prunellae Spica, rehmanniae radix, stigma Maydis, saviae Miltiorrhizae radix, caulis Lonicerae and fructus Rosae Laevigatae in adjuvant, soaking in ethanol for 1-2 hr, taking out residues to obtain extract of the adjuvant, concentrating the extract of the adjuvant into extract, drying the extract, and pulverizing to obtain adjuvant powder;
s3: mixing the main material powder and the auxiliary material powder uniformly, and sterilizing to obtain the capsule medicine product.
3. The traditional Chinese medicine composition for reducing blood sugar and the preparation method thereof according to claim 2, wherein the traditional Chinese medicine composition is characterized in that traditional Chinese medicines of rhizoma polygonati, catharanthus roseus, rhizoma anemarrhenae, radix trichosanthis, radix ophiopogonis, semen cassiae, herba cistanches and fructus ligustri lucidi in auxiliary materials are respectively weighed separately, one or a plurality of traditional Chinese medicines are mixed, ethanol is added for soaking for 1-1.5 hours, dregs are fished out to obtain new auxiliary material extract liquid, the new auxiliary material extract liquid is concentrated into extract, and the extract is dried and crushed to obtain new auxiliary material powder.
4. The hypoglycemic Chinese medicinal composition and the preparation method thereof according to claim 3, wherein the new auxiliary powder and the auxiliary powder are uniformly mixed to obtain the composite powder.
5. The hypoglycemic Chinese medicinal composition and the preparation method thereof according to claim 4, wherein the composite powder and the main material powder are uniformly mixed, and a capsule medicinal product is prepared after sterilization and disinfection.
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