CN117813102A - 用于改善t细胞持久性和功能的组合物和方法 - Google Patents

用于改善t细胞持久性和功能的组合物和方法 Download PDF

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Publication number
CN117813102A
CN117813102A CN202280052739.XA CN202280052739A CN117813102A CN 117813102 A CN117813102 A CN 117813102A CN 202280052739 A CN202280052739 A CN 202280052739A CN 117813102 A CN117813102 A CN 117813102A
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cell
cells
engineered
gene
tumor
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安苏曼·萨特帕蒂
朱莉娅·贝尔克
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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    • A—HUMAN NECESSITIES
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN202280052739.XA 2021-07-28 2022-07-28 用于改善t细胞持久性和功能的组合物和方法 Pending CN117813102A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163226559P 2021-07-28 2021-07-28
US63/226,559 2021-07-28
PCT/US2022/074251 WO2023010073A1 (en) 2021-07-28 2022-07-28 Compositions and methods for improving t cell persistence and function

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CN117813102A true CN117813102A (zh) 2024-04-02

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US (1) US20240327826A1 (enExample)
EP (1) EP4376858A4 (enExample)
JP (1) JP2024527997A (enExample)
CN (1) CN117813102A (enExample)
WO (1) WO2023010073A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118345080A (zh) * 2024-06-17 2024-07-16 江苏柯菲平医药股份有限公司 一种抗耗竭t细胞及其制备方法、应用
CN119120385A (zh) * 2024-11-14 2024-12-13 四川大学华西医院 一种具有长效抑瘤效果的嵌合抗原受体t细胞及其制备方法和用途

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4665363A1 (en) * 2023-02-17 2025-12-24 Dana-Farber Cancer Institute, Inc. Compositions and methods of preventing t cell exhaustion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021501156A (ja) * 2017-10-27 2021-01-14 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｔ細胞疲弊を予防および逆転するためのエピジェネティック標的および転写標的の同定
JP7505761B2 (ja) * 2017-12-15 2024-06-25 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Ｔ細胞疲弊を阻害するための組成物および方法
CN118325839A (zh) * 2018-03-27 2024-07-12 宾夕法尼亚大学董事会 具有增强功能的修饰的免疫细胞及其筛选方法
CN110904045A (zh) * 2018-09-17 2020-03-24 中国科学院动物研究所 经修饰的t细胞、其制备方法及用途
WO2020198340A1 (en) * 2019-03-26 2020-10-01 The Trustees Of The University Of Pennsylvania Dnmt3a knockout car t cells for adoptive immunotherapy
WO2020219682A2 (en) * 2019-04-24 2020-10-29 St. Jude Children's Research Hospital, Inc. Gene knock-outs to improve t cell function

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118345080A (zh) * 2024-06-17 2024-07-16 江苏柯菲平医药股份有限公司 一种抗耗竭t细胞及其制备方法、应用
CN119120385A (zh) * 2024-11-14 2024-12-13 四川大学华西医院 一种具有长效抑瘤效果的嵌合抗原受体t细胞及其制备方法和用途
CN119120385B (zh) * 2024-11-14 2025-03-14 四川大学华西医院 一种具有长效抑瘤效果的嵌合抗原受体t细胞及其制备方法和用途

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US20240327826A1 (en) 2024-10-03
JP2024527997A (ja) 2024-07-26
EP4376858A4 (en) 2025-10-01
EP4376858A1 (en) 2024-06-05
WO2023010073A1 (en) 2023-02-02

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