CN117796954A - Fixing support for injection of big mouse occipital cell - Google Patents

Abstract

The invention discloses a fixing bracket for injection of a big mouse occipital pond, which comprises a bottom plate and a positioning component, wherein the positioning component comprises a sliding seat which is arranged on the bottom plate in a sliding and clamping way, a hydraulic rod is arranged on the sliding seat, the output rod end of the hydraulic rod is fixedly connected with a connecting seat, one side of the connecting seat is vertically provided with a measuring ruler, the top end of the connecting seat is rotatably clamped with a pair of clamping frames, the opposite ends of the tops of the two clamping frames are provided with clamps, a pull rod is arranged in the connecting seat in a sliding and clamping way, two sides of one end of the pull rod are respectively provided with a slide rod, the clamping frames are arranged on the slide rods in a sliding and clamping way, two sides of the pull rod are respectively provided with a fixing plate, and the fixing plates are connected with the adjacent clamping frames through first tension springs; the positioning component provided by the invention can fix the needle cylinder for mouse injection, can move in the vertical direction and rotate in a small angle in the vertical plane, so that the needle head is better aligned with the occipital macropore of the mouse, the death of the mouse after injection is prevented, the death rate of the mouse is further reduced, and the practicability of the device is improved.

Description

Fixing support for injection of big mouse occipital cell

Technical Field

The invention relates to the technical field of biological experimental equipment, in particular to a fixing bracket for injecting a mouse occipital vat.

Background

In the animal experiments based on mice, the correct mouse injection method can ensure the state of the mice, obtain reliable experimental data, generally needs to inject a specified reagent into living mice, and keep the mice biologically active to observe the results after injection, and the injection modes aiming at the mice mainly comprise intraperitoneal injection, intravenous injection, intramuscular injection, intraparenchymal injection, occipital injection and the like.

However, since the injection of the mouse occipital vat can only be performed through the occipital macropores of the mouse, the injection direction needs to be kept in a near horizontal direction, and most of the existing fixing brackets for mouse injection are used for accurately positioning and injecting the brain of the mouse after determining the coordinates in the vertical direction, so that the needle head cannot be aligned to the occipital macropores, and the practicability of the device is reduced.

Disclosure of Invention

The invention provides a fixing bracket for injecting a big mouse occipital cell, which aims to solve the problems that most of fixing brackets for injecting mice in the prior art accurately position and inject the brain of the mice after determining coordinates in the vertical direction, and a needle head cannot be aligned to the occipital macropore, so that the practicability of the device is reduced.

In order to achieve the above purpose, the present invention provides the following technical solutions:

the utility model provides a mouse pillow big pond fixed bolster for injection, includes bottom plate and locating component, locating component includes the sliding seat that the slip card was established on the bottom plate, be provided with the hydraulic stem on the sliding seat, hydraulic stem output rod end fixedly connected with connecting seat, connecting seat one side is vertical to be provided with the measuring tape, the connecting seat top rotates the card and is equipped with a pair of holder, two the opposite ends in holder top are provided with the clamping, the slip card is equipped with the pull rod in the connecting seat, pull rod one end both sides all are provided with the slide bar, the holder slip card is established on the slide bar, the pull rod both sides all are provided with the fixed plate, the fixed plate with be adjacent be connected through first extension spring between the holder.

Preferably, a plurality of scale marks are formed on the pull rod, a scribing groove is formed in the connecting seat, the scribing groove is aligned with any scale mark, a friction plate is connected to the connecting seat in a threaded manner, and one end, close to the pull rod, of the friction plate is in extrusion contact with one side of the pull rod.

Preferably, a rotating rod connected through a first spring is arranged on one side of the sliding seat, a gear is coaxially connected to the rotating rod, a rectangular block is arranged on one side of the gear, a push plate is arranged at the free end of the rotating rod, a rack is arranged on the bottom plate, the gear is meshed with the rack, and the rectangular block is slidably clamped on the bottom plate.

Preferably, a pair of first bandage and second bandage are provided on the sliding seat, the free end of the first bandage is hinged with a lantern ring, and the two sides of the second bandage are respectively provided with a sticky surface and a rough surface of the magic tape.

Preferably, the bottom plate is provided with a fixing assembly, the fixing assembly comprises a pair of positioning seats which are clamped on the bottom plate in a sliding manner, an adjusting screw rod which is vertically and spirally connected with the positioning seats is clamped on the bottom plate in a rotating manner, an ear cone is clamped on the positioning seats in a sliding manner, a stud is connected on the positioning seats in a threaded manner, a knob is arranged at one end of the stud in a sliding manner through a moving block in a clamping manner, and the knob is clamped on the positioning seats in a rotating manner.

Preferably, two connect through the linking bridge between the positioning seat, be provided with sliding connection's fixing base on the linking bridge, the friction groove has been seted up on the fixing base, the slip card is equipped with the clutch block on the fixing base, the clutch block top is provided with the pull ring, the pull ring bottom with connect through the second extension spring between the linking bridge, the clutch block bottom with friction groove extrusion contact, be provided with the clamping assembly on the fixing base.

Preferably, the clamping assembly comprises a clamping seat which is arranged on the fixing seat in a sliding clamping manner through a dovetail groove, a positioning button which is in threaded connection is arranged on the clamping seat, one end of the positioning button is in extrusion contact with the dovetail groove, a metal rod is arranged on the clamping seat in a rotating clamping manner, one end of the metal rod is provided with a pressing plate, and the pressing plate is connected with the clamping seat through a second spring.

The principle and beneficial effect of this technical scheme:

(1) The positioning component can fix the needle cylinder for mouse injection, can move in the vertical direction and rotate in a small angle in the vertical plane, so that the needle head is better aligned with the occipital macropore of the mouse, the death of the mouse after injection is prevented, the head of the mouse after anesthesia is fixed on the bottom plate through the fixing component, the clamping component and the like before the positioning component is used, at the moment, two second binding bands penetrate into the sleeve rings at corresponding positions, after the first binding band and the second binding band compress the mouse, the magic tape adhesive surface of the second binding band is adhered to the hair surface, the fixing of the trunk of the mouse is completed, at the moment, the push plate arranged at one end of the rotating rod is pressed, the rectangular block is separated from the clamping with the bottom plate, at the moment, the first spring is compressed, at the same time, the gear coaxially connected with the rotating rod is meshed with the rack on the bottom plate, at the moment, the gear on the rotating rod can move along the extending direction of the rack, the rotating rod is driven to move through a sliding seat connected with a first spring, the mouse trunk fixed on the sliding seat moves synchronously, the inclination angle of the mouse skull is changed by translating the mouse trunk until the occipital bone big hole of the mouse moves to the near horizontal direction, at the moment, a reagent injection needle cylinder is taken out, a clamping frame clamped on a sliding rod is pulled outwards in a sliding way, two clamping clamps at the top end of the clamping frame are far away, the injection needle cylinder is clamped between the two clamping frames, then a hydraulic rod is driven to extend, a connecting seat fixed at the output rod end of the hydraulic rod moves to a proper height, at the moment, the angle between the clamping frames and the horizontal direction is finely adjusted according to the position of the occipital bone big hole of the mouse, a screwed friction plate on the connecting seat is rotated to ensure that the friction plate is not in extrusion contact with the pull rod, at the moment, the pull rod is slid along the bottom of the connecting seat, the position of the sliding rod is controlled according to a scale line aligned with a scale line, the movement of the slide bar can enable the clamp to rotate, the friction plate is reset after the clamp rotates to a proper angle, the pull rod is positioned again, at the moment, the injection is carried out manually or by an external injection pump, the device can be used for injecting the mouse occipital macropore in the horizontal direction, the death rate of the mouse is further reduced, and the practicability of the device is improved.

(2) The fixing component provided by the invention can fix the axle of the head of the mouse through the ear cone, the head of the anesthetized mouse is arranged between the two positioning seats, the knob is rotated to enable the stud and the moving block to move upwards, the stud moves upwards to be separated from the clamping of the ear cone, the ear cone is transversely moved, the two ear cones are clamped into the ears of the mouse until the ear cone abuts against the auricular anterior temporal bone of the mouse, and at the moment, the stud is reset by reversely rotating the knob.

(3) The clamping assembly arranged in the invention can clamp the mouth of the mouse, so that the mouse is prevented from being bitten by an experimenter during the injection observation period, before the clamping assembly is used, the position of the positioning seat and the connecting frame between the positioning seats is simultaneously adjusted through the adjusting screw, then the pull ring is pulled up, the friction block arranged at the through bottom end of the tension spring is separated from extrusion contact with the friction groove, at the moment, the fixing seat is slid along the connecting frame, the clamping assembly arranged on the fixing seat is moved to the mouth of the mouse, the positioning button is released to adjust the height of the clamping seat, then the pressing plate is pressed down, the metal rod connected with the pressing plate is rotated, at the moment, the second spring is compressed, the mouth of the mouse is penetrated to the bottom end of the clamping seat, and then the clamping plate is slowly released, so that the metal rod resets to clamp the head of the mouse.

Drawings

FIG. 1 is a schematic view of an assembled structure of the present invention;

FIG. 2 is a schematic diagram of the split structure of the present invention;

FIG. 3 is an enlarged schematic view of the area A in FIG. 2;

FIG. 4 is an enlarged schematic view of the area B in FIG. 2;

FIG. 5 is an enlarged schematic view of the area C in FIG. 2;

reference numerals in the drawings of the specification include: 1. a bottom plate; 2. a sliding seat; 3. a connection frame; 4. a rack; 5. a push plate; 6. a pull ring; 7. a second tension spring; 8. a friction block; 9. a dovetail groove; 10. a friction groove; 11. a fixing seat; 12. adjusting a screw; 13. a second strap; 14. a rotating rod; 15. a first spring; 16. a gear; 17. rectangular blocks; 18. a clip; 19. a clamping frame; 20. a slide bar; 21. a pull rod; 22. a connecting seat; 23. scribing grooves; 24. a measuring scale; 25. a first tension spring; 26. a first strap; 27. a collar; 28. a fixing plate; 29. a friction plate; 30. a hydraulic rod; 31. a knob; 32. a moving block; 33. ear cone; 34. a stud; 35. a positioning seat; 36. a metal rod; 37. a positioning button; 38. a clamping seat; 39. a pressing plate; 40. and a second spring.

Detailed Description

The invention is described in further detail below with reference to the attached drawings and embodiments:

examples:

as shown in fig. 1 to 5, the invention provides a fixing support for injecting a big pool of a mouse pillow, which comprises a bottom plate 1 and a positioning component, wherein the positioning component comprises a sliding seat 2 which is arranged on the bottom plate 1 in a sliding and clamping manner, a hydraulic rod 30 is arranged on the sliding seat 2, the output rod end of the hydraulic rod 30 is fixedly connected with a connecting seat 22, one side of the connecting seat 22 is vertically provided with a measuring ruler 24, the top end of the connecting seat 22 is rotatably clamped with a pair of clamping frames 19, the opposite ends of the tops of the two clamping frames 19 are provided with clamping clips 18, a pull rod 21 is arranged in the connecting seat 22 in a sliding and clamping manner, sliding rods 20 are arranged on two sides of one end of the pull rod 21, the clamping frames 19 are arranged on the sliding rods 20 in a sliding and clamping manner, two sides of the pull rod 21 are provided with fixing plates 28, and the fixing plates 28 are connected with the adjacent clamping frames 19 through first tension springs 25.

As shown in fig. 3, the pull rod 21 is provided with a plurality of scale marks, the connecting seat 22 is internally provided with a scribing groove 23, the scribing groove 23 is used for a Ji Ren scale mark, the connecting seat 22 is connected with a friction plate 29 in a threaded manner, and one end of the friction plate 29, which is close to the pull rod 21, is in extrusion contact with one side of the pull rod 21.

As shown in fig. 1 and 2, a rotating rod 14 connected by a first spring 15 is arranged on one side of the sliding seat 2, a gear 16 is coaxially connected to the rotating rod 14, a rectangular block 17 is arranged on one side of the gear 16, a push plate 5 is arranged at the free end of the rotating rod 14, a rack 4 is arranged on the bottom plate 1, the gear 16 is meshed with the rack 4, and the rectangular block 17 is slidably clamped on the bottom plate 1.

As shown in fig. 1 to 3, the sliding seat 2 is provided with a pair of first binding bands 26 and second binding bands 13, the free ends of the first binding bands 26 are hinged with a lantern ring 27, and two sides of the second binding bands 13 are respectively provided with a sticky surface and a rough surface of the magic tape.

As shown in fig. 1, 2 and 4, a fixing component is arranged on the bottom plate 1, the fixing component comprises a pair of positioning seats 35 which are slidably clamped on the bottom plate 1, an adjusting screw 12 which is vertically and spirally connected with the positioning seats 35 is rotatably clamped on the bottom plate 1, an ear cone 33 is slidably clamped on the positioning seats 35, a stud 34 is spirally connected with the positioning seats 35, a knob 31 is slidably clamped at one end of the stud 34 through a moving block 32, and the knob 31 is rotatably clamped on the positioning seats 35.

The fixing component can fix the axis of the head of the mouse through the ear cone 33, the head of the anesthetized mouse is placed between the two positioning seats 35, the knob 31 is rotated to enable the stud 34 and the moving block 32 to move upwards, the stud 34 moves upwards to be separated from the clamping of the ear cone 33, the ear cone 33 is transversely moved, the two ear cones 33 are clamped into the ears of the mouse until the ear cone 33 abuts against the auricular anterior temporal bone of the mouse, and at the moment, the knob 31 is reversely rotated to enable the stud 34 to reset.

As shown in fig. 1 and 2, two positioning seats 35 are connected through a connecting frame 3, a fixing seat 11 in sliding connection is arranged on the connecting frame 3, a friction groove 10 is formed in the fixing seat 11, a friction block 8 is arranged on the fixing seat 11 in a sliding clamping manner, a pull ring 6 is arranged at the top end of the friction block 8, the bottom end of the pull ring 6 is connected with the connecting frame 3 through a second tension spring 7, the bottom end of the friction block 8 is in extrusion contact with the friction groove 10, and a clamping assembly is arranged on the fixing seat 11.

As shown in fig. 2 and 5, the clamping assembly comprises a clamping seat 38 slidably clamped by the dovetail groove 9 on the fixing seat 11, a positioning button 37 in threaded connection is arranged on the clamping seat 38, one end of the positioning button 37 is in extrusion contact with the dovetail groove 9, a metal rod 36 is rotatably clamped on the clamping seat 38, one end of the metal rod 36 is provided with a pressing plate 39, and the pressing plate 39 is connected with the clamping seat 38 through a second spring 40.

The clamping assembly can clamp the mouth of the mouse, so that the experiment personnel can be prevented from being bitten by awakening in the injection observation period of the mouse, before the clamping assembly is used, the position of the connecting frame 3 between the positioning seat 35 and the positioning seat 35 is simultaneously adjusted through the adjusting screw 12, then the pull ring 6 is pulled up, the friction block 8 arranged at the through bottom end of the tension spring is separated from extrusion contact with the friction groove 10, the fixing seat 11 is slid along the connecting frame 3 at the moment, the clamping assembly arranged on the fixing seat 11 is moved to the mouth of the mouse, the positioning button 37 is loosened to adjust the height of the clamping seat 38, then the pressing plate 39 is pressed down, the metal rod 36 connected with the pressing plate 39 is rotated, at the moment, the second spring is compressed, the mouth of the mouse is penetrated to the bottom end of the clamping seat 38, and then the clamping plate is slowly loosened to reset the metal rod 36 to clamp the head of the mouse.

Specific use and action of the embodiment:

the locating component provided by the invention can fix the needle cylinder for mouse injection, can move in the vertical direction and rotate in a small angle in the vertical plane, so that the needle head is better aligned with the occipital macropore of the mouse, the death of the mouse after injection is prevented, before the locating component is used, the head of the mouse after anesthesia is fixed on the bottom plate 1 through the fixing component, the clamping component and the like, at the moment, two second binding bands 13 are penetrated into the lantern rings 27 at corresponding positions, after the first binding band 26 and the second binding band 13 compress the mouse, the magic adhesive surface of the second binding band 13 is adhered to the rough surface to finish the fixation of the mouse trunk, at the moment, the push plate 5 arranged at one end of the side pressing rotating rod 14 is separated from the clamping with the bottom plate 1, at the moment, the first spring 15 is compressed, at the moment, the gear 16 coaxially connected with the rotating rod 14 is meshed with the rack 4 on the bottom plate 1, at the moment, the rotating rod 14 is rotated, the gear 16 on the rotating rod 14 moves along the extending direction of the rack 4, and then drives the rotating rod 14 to move through the sliding seat 2 connected with the first spring 15, the mouse trunk fixed on the sliding seat 2 moves synchronously, the inclination angle of the mouse skull is changed by translating the mouse trunk until the occipital bone macropore of the mouse moves to the near horizontal direction, at the moment, the syringe filled with the reagent is taken out, the clamping frame 19 clamped on the sliding rod 20 is pulled outwards, the two clips 18 at the top end of the clamping frame 19 are far away, the syringe is clamped between the two clips 18, then the hydraulic rod 30 is driven to extend, the connecting seat 22 fixed at the output rod end of the hydraulic rod 30 moves to a proper height, at the moment, the angle between the clips 18 and the horizontal direction is finely adjusted according to the position of the occipital bone macropore of the mouse, the screwed friction plate 29 on the connecting seat 22 is rotated to avoid extrusion contact with the pull rod 21, at the moment, the pull rod 21 is slid along the bottom of the connecting seat 22, the position of the slide bar 20 connected with the pull rod 21 is controlled according to the scale marks aligned by the scribing groove 23, the movement of the slide bar 20 can enable the clamp 18 to rotate, the friction plate 29 is reset after the clamp 18 rotates to a proper angle, the pull rod 21 is positioned again, at the moment, the injection is carried out manually or by an external injection pump, and the device can be used for injecting the mouse occipital macropore in the horizontal direction, so that the death rate of the mouse is reduced, and the practicability of the device is improved.

The foregoing is merely exemplary of the present invention, and specific technical solutions and/or features that are well known in the art have not been described in detail herein. It should be noted that, for those skilled in the art, several variations and modifications can be made without departing from the technical solution of the present invention, and these should also be regarded as the protection scope of the present invention, which does not affect the effect of the implementation of the present invention and the practical applicability of the patent. The protection scope of the present application shall be subject to the content of the claims, and the description of the specific embodiments and the like in the specification can be used for explaining the content of the claims.

Claims (7)

1. The utility model provides a fixed bolster is used in injection of big pond of mouse pillow which characterized in that: including bottom plate (1) and locating component, locating component includes sliding seat (2) that slide card was established on bottom plate (1), be provided with hydraulic stem (30) on sliding seat (2), hydraulic stem (30) output rod end fixedly connected with connecting seat (22), connecting seat (22) one side is vertical to be provided with measuring tape (24), connecting seat (22) top rotates the card and is equipped with a pair of holder (19), two holder (19) top opposite end is provided with clamping (18), sliding card is equipped with pull rod (21) in connecting seat (22), pull rod (21) one end both sides all are provided with slide bar (20), holder (19) slide card is established on slide bar (20), pull rod (21) both sides all are provided with fixed plate (28), fixed plate (28) are adjacent through first extension spring (25) between holder (19).

2. The fixing bracket for injecting a mouse occipital cell according to claim 1, wherein: the novel drawing device is characterized in that a plurality of scale marks are formed in the draw rod (21), a scribing groove (23) is formed in the connecting seat (22), the scribing groove (23) is aligned to any scale mark, a friction plate (29) is connected to the connecting seat (22) in a threaded mode, and one end, close to the draw rod (21), of the friction plate (29) is in extrusion contact with one side of the draw rod (21).

3. The fixing bracket for injecting a mouse occipital cell according to claim 2, wherein: the sliding seat is characterized in that a rotating rod (14) connected through a first spring (15) is arranged on one side of the sliding seat, a gear (16) is coaxially connected to the rotating rod (14), a rectangular block (17) is arranged on one side of the gear (16), a push plate (5) is arranged at the free end of the rotating rod (14), a rack (4) is arranged on the bottom plate (1), the gear (16) is meshed with the rack (4), and the rectangular block (17) is slidably clamped on the bottom plate (1).

4. A mouse occipital cell injection fixing bracket according to claim 3, wherein: a pair of first binding bands (26) and second binding bands (13) are arranged on the sliding seat (2), the free ends of the first binding bands (26) are hinged with lantern rings (27), and the two sides of the second binding bands (13) are respectively provided with sticky faces and rough faces of magic tapes.

5. The fixing bracket for injecting a mouse occipital cell according to claim 4, wherein: the utility model discloses a floor, including bottom plate (1), be provided with fixed subassembly on bottom plate (1), fixed subassembly includes a pair of positioning seat (35) that slide card was established on bottom plate (1), adjusting screw (12) rotation card of vertical spiro union on positioning seat (35) are established on bottom plate (1), slide card on positioning seat (35) is equipped with ear cone (33), the spiro union has double-screw bolt (34) on positioning seat (35), double-screw bolt (34) one end is equipped with knob (31) through movable block (32) slide card, knob (31) rotation card is established on positioning seat (35).

6. The fixing bracket for injecting a mouse occipital cell according to claim 5, wherein: two connect through connecting frame (3) between positioning seat (35), be provided with sliding connection's fixing base (11) on connecting frame (3), friction groove (10) have been seted up on fixing base (11), the slip card is equipped with clutch blocks (8) on fixing base (11), clutch blocks (8) top is provided with pull ring (6), pull ring (6) bottom with connect through second extension spring (7) between connecting frame (3), clutch blocks (8) bottom with friction groove (10) extrusion contact, be provided with clamping assembly on fixing base (11).

7. The fixing bracket for injecting a mouse occipital cell according to claim 6, wherein: the clamping assembly comprises a clamping seat (38) which is arranged on the fixing seat (11) in a sliding clamping manner through a dovetail groove (9), a positioning button (37) which is in threaded connection is arranged on the clamping seat (38), one end of the positioning button (37) is in extrusion contact with the dovetail groove (9), a metal rod (36) is rotatably clamped on the clamping seat (38), one end of the metal rod (36) is provided with a pressing plate (39), and the pressing plate (39) is connected with the clamping seat (38) through a second spring (40).