CN117796480A - Hydrogen-containing beverage for reducing accumulation of acetaldehyde after drinking and preparation method thereof - Google Patents
Hydrogen-containing beverage for reducing accumulation of acetaldehyde after drinking and preparation method thereof Download PDFInfo
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- CN117796480A CN117796480A CN202310878659.6A CN202310878659A CN117796480A CN 117796480 A CN117796480 A CN 117796480A CN 202310878659 A CN202310878659 A CN 202310878659A CN 117796480 A CN117796480 A CN 117796480A
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- Non-Alcoholic Beverages (AREA)
Abstract
The invention discloses a hydrogen-containing beverage for reducing accumulation of acetaldehyde after drinking and a preparation method thereof, wherein the hydrogen-containing beverage comprises active ingredients, hydrogen and food acceptable auxiliary materials; the active ingredients are extracts of the following components in parts by weight: 80-150 parts of rhizoma polygonati, 80-170 parts of radix puerariae, 200-300 parts of semen hoveniae, 100-150 parts of dark plum, 30-60 parts of liquorice and 100-150 parts of bergamot; the hydrogen-containing beverage can effectively inhibit the activity of alcohol dehydrogenase, improve the activity of acetaldehyde dehydrogenase, reduce accumulation of acetaldehyde after drinking, remove O2-free radicals and hydroxyl free radicals generated in the alcohol metabolism process and reduce the harm of drinking.
Description
Technical Field
The invention relates to the technical field of food and beverage, in particular to a hydrogen-containing beverage for reducing accumulation of acetaldehyde after drinking and a preparation method thereof.
Background
There is a long history of white wine culture in our country. The wine is better for medical care and treatment. The white spirit not only has wide consumer groups, but also bears the long-term cultural tradition of China, and is an important component of the Chinese traditional culture. However, drinking is harmful to health, especially alcohol allergy people drink wine which has a great influence on health, and consensus is formed in the whole society, so that the transmission of white spirit and white spirit culture is seriously influenced. However, alcohol is harmful or drunk and is harmful to health, and the actual situation is that the alcohol has the effects of activating blood circulation to dissipate blood stasis, improving yang qi of a human body, relieving pressure and making people feel pleasure.
After entering the human body, the ethanol is absorbed by organs such as oral cavity, esophagus, stomach, intestine and the like, directly enters the blood circulation, and is rapidly transported to all tissues and organs of the whole body for metabolism. Wherein, the alcohol absorbed by the lower section of the stomach and the intestinal tract enters the liver through blood circulation, about 90-95% of the alcohol is metabolized in the liver, and only 2-10% of the alcohol is discharged out of the body in an original shape through kidneys, lungs, sweat and the like. Ethanol is oxidized to generate acetaldehyde under the action of alcohol dehydrogenase of liver, and then acetic acid is generated under the action of acetaldehyde dehydrogenase, so that carbon dioxide and water are formed, and energy is released. Among them, acetaldehyde is a direct contributor to liver injury, and it can damage mitochondria in liver cells, thereby reducing the decomposition function of liver cells to fatty acids, and forming fatty liver. Acetaldehyde can also form superoxide under the action of xanthine oxidase, causing lipid peroxidation, resulting in liver injury, and causing degeneration of hepatocytes. Acetaldehyde can also bind to proteins to form acetaldehyde complexes, resulting in loss of protein function, induction of fibrosis formation and induction of abnormal immune responses, leading to re-destruction of hepatocytes. Cytochrome P450 plays a major role in the ethanol microsomal oxidation system, which involves the metabolism of a variety of compounds (including carcinogens) in vitro. Acetaldehyde also causes a deficiency in reduced Glutathione (GSH) activity in mitochondria, leading to O production by the respiratory chain 2 Free radical cannot be transported in time, and SOD activity, O of superoxide dismutase is destroyed 2 Free radical is unable to form H 2 O 2 Resulting in lipid peroxidation of the mitochondria.
Therefore, the alcohol metabolic intermediate acetaldehyde is truly harmful to human health, and alcohol drinking allergy or alcohol drinking damage to health is mainly caused by deficiency of acetaldehyde metabolizing enzyme or insufficient activity of acetaldehyde metabolizing enzyme, and simultaneously, the alcohol dehydrogenase activity is too high, so that acetaldehyde is accumulated in the human body after drinking. Mitochondria are the primary storage sites and production organs for intracellular redox reactions. As long as the activity of alcohol dehydrogenase is inhibited, the activity of acetaldehyde metabolizing enzyme is improved, the decomposition of acetaldehyde can be enhanced, and the accumulation of acetaldehyde in the body can be reduced, so that the harm of drinking to health can be reduced, and the components beneficial to health can be reserved.
Disclosure of Invention
Aiming at the problems existing in the prior art, the invention provides a hydrogen-containing beverage for inhibiting the activity of alcohol dehydrogenase, improving the activity of acetaldehyde dehydrogenase, removing oxygen free radicals generated in the alcohol metabolism process and reducing accumulation of drunk acetaldehyde and a preparation method thereof.
The beverage has reasonable compatibility of the medicinal components, and can play roles in moistening lung, promoting fluid production, quenching thirst, clearing heat and detoxicating, protecting intestines and stomach, activating acetaldehyde dehydrogenase and reducing acetaldehyde accumulation. And after hydrogen is added, the hydrogen can eliminate hydroxyl free radicals and oxygen free radicals, so that the damage of the free radicals generated in the alcohol metabolism process to the liver is reduced. The hydrogen can also play a role in protecting liver and enhancing the anti-alcohol effect of the medicinal materials.
Wherein, the rhizoma polygonati is also called rhizoma polygonati, radix polygonati officinalis, rhizoma zingiberis, and radix polygonati officinalis. Has effects of invigorating spleen, moistening lung and promoting salivation. The rhizoma Polygonati decoction with concentration of 17.67% is injected into abdominal cavity at a concentration of 0.3ml, and can prolong swimming time of mice. Simultaneously, the rhizoma polygonati also has an antioxidation effect: the rhizoma Polygonati decoction has concentration of 20%, 13 ml/drink, and can raise liver superoxide dismutase (SOD) activity of mice and reduce myocardial lipofuscin content for 27 days. Radix Puerariae is the dried root of Pueraria lobata Ohwi of Leguminosae, and is known as Pueraria lobata Ohwi. Sex taste: sweet, pungent and cool, has the actions of relieving muscle and fever, promoting eruption, promoting fluid production to quench thirst, ascending yang and stopping diarrhea. It is commonly used for exterior syndrome with fever, pain in the neck and back, measles, thirst due to fever, diabetes due to yin deficiency, diarrhea due to heat-purging, spleen deficiency, diarrhea. Puerarin is rich in puerarin, and has effects of enhancing immunity, enhancing myocardial contractility, protecting myocardial cells, lowering blood pressure, and resisting platelet aggregation. The specific effects are that the regeneration capacity of liver cells is improved, the normal liver function is recovered, the bile secretion is promoted, and fat accumulation in the liver is prevented; promoting metabolism, enhancing liver detoxification function, and preventing alcohol from damaging liver. Hovenia dulcis thunb is also called papaw. Sweet in taste, mild in nature, nontoxic, capable of quenching thirst, relieving restlessness, removing diaphragmatic upper heat, moistening five viscera, facilitating urination and defecation, and similar to honey, and is an ideal fruit for diabetics. Hovenia dulcis thunb is suitable for symptoms such as diabetes, drunk, polydipsia, vomiting and fever. Modern medical research shows that the semen hoveniae water extract has the effects of activating acetaldehyde dehydrogenase and reducing acetaldehyde accumulation. Bergamot, the fruit, when ripe, each carpel separates, forming an elongated curved fruit flap, like a finger, so the name bergamot. The fruit is big for medicine, the skin is bright yellow, wrinkled and glossy, the top ends are divergent, the fruit is often spread like fingers, the meat is white, and no seeds exist. Sex taste: pungent, bitter, sweet, warm, nontoxic; it has the functions of regulating qi, resolving phlegm, relieving vomiting, relieving distension, dispersing stagnated liver qi, invigorating spleen, regulating stomach, etc. The mume fructus is prepared from mume fructus, fructus mume, huang Zai, fructus Hancei, and dry prune, which is near mature fruit of prune of Rosaceae deciduous arbor plant, by smoking with smoke and fire. Dark plum contains more potassium and less sodium, so people who need to take potassium-expelling diuretics for a long time should eat the dark plum; the plum contains theanine which can promote intestinal peristalsis, so people with constipation are suitable to eat. The plum contains various organic acids and has the effect of improving liver function, so patients with liver diseases should eat the plum. The plum acid in plum can soften blood vessel, delay arteriosclerosis, and prevent aging. Sex taste: sour, astringent, and flat; enter liver, spleen, lung and large intestine meridians. Has effects in astringing lung, astringing intestine, promoting salivation, and relieving ascariasis. Can be used for treating chronic cough due to lung deficiency; deficiency-heat polydipsia; meanwhile, the wine also has the functions of protecting intestines and stomach and dispelling alcohol effects.
The liquorice is named old, sweet grass, urale liquorice and sweet root. The roots and rhizomes of the perennial herbs of the leguminous plants and the liquorice are thick and strong, and the liquorice is a tonic Chinese herbal medicine. Slight smell, sweet and special taste. The functions of the medicine are mainly clearing heat and detoxicating, eliminating phlegm and relieving cough, and the like. Dry weather with dark and moist taste, long sunlight and low air temperature. Honggunian is a major herb, and the meridian prescription is not used as if there were agilawood in the fragrance.
The technical scheme adopted by the invention is as follows:
a hydrogen-containing beverage for reducing accumulation of acetaldehyde after drinking comprises effective components, hydrogen and food acceptable adjuvants; the active ingredients are extracts of the following components in percentage by mass: 80-150 parts of rhizoma polygonati, 80-170 parts of radix puerariae, 200-300 parts of semen hoveniae, 100-150 parts of dark plum, 30-60 parts of liquorice and 100-150 parts of bergamot.
Further, the active ingredients are extracts of the following components in parts by weight: 100-120 parts of rhizoma polygonati, 100-150 parts of radix puerariae, 220-250 parts of semen hoveniae, 120-140 parts of dark plum, 40-50 parts of liquorice and 120-140 parts of bergamot.
Further, the active ingredients are extracts of the following components in parts by weight: 100 parts of rhizoma polygonati, 100 parts of radix puerariae, 250 parts of semen hoveniae, 100 parts of dark plum, 50 parts of liquorice and 100 parts of bergamot.
Further, the auxiliary material is a sweetener.
Further, the sweetener is one or a mixture of more than two of D-mannitol, xylitol, isomalt, sorbitol, high maltose powder and white granulated sugar in any proportion.
A method for preparing a hydrogen-containing beverage for reducing accumulation of acetaldehyde in a body, comprising the steps of:
step 1: purifying the active ingredient with water, and dissolving the extract in water;
step 2: adding auxiliary materials into the solution obtained in the step 1;
step 3: hydrogenation, fully and uniformly mixing, canning and sterilizing to obtain the hydrogen-containing beverage.
Further, the concentration of hydrogen in the solution in the step 3 is 1.2ppm.
Further, the auxiliary material is xylitol.
The beneficial effects of the invention are as follows:
(1) The invention can achieve the effects of moistening lung, promoting the production of body fluid to quench thirst, clearing heat and detoxicating, protecting intestines and stomach, activating acetaldehyde dehydrogenase and reducing acetaldehyde accumulation through the compatibility of various medicinal materials;
(2) The invention can eliminate hydroxyl free radical, reduce the damage of free radical generated in alcohol metabolism to liver, protect liver and strengthen the medicinal material to relieve alcohol effect.
Detailed Description
A hydrogen-containing beverage for reducing accumulation of acetaldehyde in human body comprises effective components, hydrogen and food acceptable adjuvants; the active ingredients are extracts of the following components in parts by weight: 80-150 parts of rhizoma polygonati, 80-170 parts of radix puerariae, 200-300 parts of semen hoveniae, 100-150 parts of dark plum, 30-60 parts of liquorice and 100-150 parts of bergamot. Preferably, the effective components are extracts of the following components in parts by weight: 100-120 parts of rhizoma polygonati, 100-150 parts of radix puerariae, 220-250 parts of semen hoveniae, 120-140 parts of dark plum, 40-50 parts of liquorice and 120-140 parts of bergamot.
The auxiliary material is sweetener. The sweetener is one or more of D-mannitol, xylitol, isomaltulose alcohol, sorbitol, high maltose powder, and white sugar.
A method for preparing a hydrogen-containing beverage for reducing accumulation of acetaldehyde in a body, comprising the steps of:
step 1: purifying the active ingredient with water, and dissolving the extract in water;
step 2: adding auxiliary materials into the solution obtained in the step 1;
step 3: hydrogenation of 1.2ppm, fully and uniformly mixing, canning in a hydrogen-resistant container, and sterilizing by irradiation to obtain the hydrogen-containing beverage.
Example 1
A method for preparing a hydrogen-containing beverage for reducing accumulation of acetaldehyde in a body, comprising the steps of:
step 1: purifying the effective components with water, dissolving the extract in water, wherein the mass concentration of the extract is 8wt.% (calculated as raw medicine);
the effective components comprise rhizoma polygonati, radix puerariae, semen hoveniae, dark plum, liquorice and bergamot in parts by weight:
150 parts of rhizoma polygonati, 80 parts of radix puerariae, 200 parts of semen hoveniae, 150 parts of dark plum, 30 parts of liquorice and 150 parts of bergamot.
Step 2: step 2: adding xylitol serving as a sweetener into the solution obtained in the step 1; the mass concentration of the extract and xylitol in water was 1wt.%;
step 3: adding 1.2ppm of nano bubble hydrogen, fully and uniformly mixing, canning in a hydrogen-resistant container, and performing irradiation sterilization to obtain the hydrogen-containing beverage.
Example 2
A method for preparing a hydrogen-containing beverage for reducing accumulation of acetaldehyde in a body, comprising the steps of:
step 1: purifying the effective components with water, dissolving the extract in water, wherein the mass concentration of the extract is 8wt.% (calculated as raw medicine);
the effective components comprise rhizoma polygonati, radix puerariae, semen hoveniae, dark plum, liquorice and bergamot in parts by weight:
80 parts of rhizoma polygonati, 150 parts of kudzuvine root, 300 parts of semen hoveniae, 120 parts of dark plum, 40 parts of liquorice and 120 parts of bergamot.
Step 2: step 2: adding xylitol serving as a sweetener into the solution obtained in the step 1; the mass concentration of the extract and xylitol in water was 1wt.%;
step 3: adding 1.2ppm of nano bubble hydrogen, fully and uniformly mixing, canning in a hydrogen-resistant container, and performing irradiation sterilization to obtain the hydrogen-containing beverage.
Example 3
A method for preparing a hydrogen-containing beverage for reducing accumulation of acetaldehyde in a body, comprising the steps of:
step 1: purifying the effective components with water, dissolving the extract in water, wherein the mass concentration of the extract is 8wt.% (calculated as raw medicine);
the effective components comprise rhizoma polygonati, radix puerariae, semen hoveniae, dark plum, liquorice and bergamot in parts by weight:
100 parts of rhizoma polygonati, 100 parts of radix puerariae, 250 parts of semen hoveniae, 100 parts of dark plum, 50 parts of liquorice and 100 parts of bergamot.
Step 2: step 2: adding xylitol serving as a sweetener into the solution obtained in the step 1; the mass concentration of the extract and xylitol in water was 1wt.%;
step 3: adding 1.2ppm of nano bubble hydrogen, fully and uniformly mixing, canning in a hydrogen-resistant container, and performing irradiation sterilization to obtain the hydrogen-containing beverage.
Example 4
A method for preparing a hydrogen-containing beverage for reducing accumulation of acetaldehyde in a body, comprising the steps of:
step 1: purifying the effective components with water, dissolving the extract in water, wherein the mass concentration of the extract is 8wt.% (calculated as raw medicine);
the effective components comprise rhizoma polygonati, radix puerariae, semen hoveniae, dark plum, liquorice and bergamot in parts by weight:
120 parts of rhizoma polygonati, 170 parts of radix puerariae, 220 parts of semen hoveniae, 140 parts of dark plum, 60 parts of liquorice and 140 parts of bergamot.
Step 2: step 2: adding xylitol serving as a sweetener into the solution obtained in the step 1; the mass concentration of the extract and xylitol in water was 1wt.%;
step 3: adding 1.2ppm of nano bubble hydrogen, fully and uniformly mixing, canning in a hydrogen-resistant container, and performing irradiation sterilization to obtain the hydrogen-containing beverage.
To illustrate the beneficial effects of the beverage of the present invention, tests were performed:
organizing 60 volunteers, immediately after taking 300ml of hydrogen-containing beverage (300 ml of water for control group), starting to drink Maotai-alcohol (53 degrees), and drinking 100ml within half an hour, taking 2.5ml of peripheral blood 2h after starting to drink, anticoagulating with sodium citrate, centrifuging 300g for 10 minutes, separating plasma, and measuring the concentration of acetaldehyde in the plasma. Taking 0.1ml of plasma, adding into 4.6ml of purified water, adding 0.3ml of 20% trichloroacetic acid, oscillating, centrifuging at 4000r/min for 10min, filtering the supernatant with a 0.45nm filter membrane, and reserving for gas chromatography determination. Chromatographic conditions: GCl22 gas chromatograph (Shanghai precision scientific instruments limited), N2000 chromatographic data workstation; quartz capillary column (PEG-20000, 30m x 2.5mm x 0.5 um); a hydrogen flame ionization detector; column temperature 70 ℃, vaporization chamber 150 ℃ and detection chamber 180 ℃; carrier gas: the front pressure of the nitrogen column is 0.12MPa, the diaphragm cleaning needle valve is adjusted to 1, the dividing needle valve scale is adjusted to 3, and the tail blowing steady flow valve scale is adjusted to 3; the hydrogen pressure is 0.12MPa, and the scale of the steady flow valve is adjusted to 5; the air pressure is 0.15MPa, and the scale of the steady flow valve is adjusted to 6; sensitivity 1010; attenuation 1. The results of the plasma acetaldehyde concentration measurements are shown in table 1: the significant decrease in plasma acetaldehyde concentration (P < 0.05), especially in formulation 3 (example 3), was very significant (P < 0.01) compared to the control group, indicating that drinking the prepared beverage had a significant decrease in blood acetaldehyde concentration, especially drinking hydrogen-containing beverage 3 (example 3), compared to the control group. The hydrogenated beverage groups all had a significant reduction in the acetaldehyde content in plasma (P < 0.05) relative to the beverage of drinking formula 3 (example 3) but without hydrogen. Thus, hydrogenation has a significant effect of reducing acetaldehyde accumulation in blood.
TABLE 1 determination of acetaldehyde content in plasma
* Has significant difference (P < 0.05) relative to the control group
# has a significant difference (P < 0.05) with respect to formulation 3 but no hydrogen addition group and $ has a very significant difference (P < 0.01) with respect to the control group.
Claims (8)
1. A hydrogen-containing beverage for reducing accumulation of acetaldehyde after drinking is characterized by comprising effective components, hydrogen and food acceptable auxiliary materials; the active ingredients are extracts of the following components in percentage by mass: 80-150 parts of rhizoma polygonati, 80-170 parts of radix puerariae, 200-300 parts of semen hoveniae, 100-150 parts of dark plum, 30-60 parts of liquorice and 100-150 parts of bergamot.
2. The hydrogen-containing beverage for reducing accumulation of acetaldehyde after drinking as claimed in claim 1, wherein the effective ingredient is an extract of the following components in parts by weight: 100-120 parts of rhizoma polygonati, 100-150 parts of radix puerariae, 220-250 parts of semen hoveniae, 120-140 parts of dark plum, 40-50 parts of liquorice and 120-140 parts of bergamot.
3. The hydrogen-containing beverage for reducing accumulation of acetaldehyde after drinking as claimed in claim 1, wherein the effective ingredient is an extract of the following components in parts by weight: 100 parts of rhizoma polygonati, 100 parts of radix puerariae, 250 parts of semen hoveniae, 100 parts of dark plum, 50 parts of liquorice and 100 parts of bergamot.
4. The hydrogen-containing beverage for reducing the accumulation of acetaldehyde after drinking as in claim 1, wherein said adjunct is a sweetener.
5. The hydrogen-containing beverage for reducing accumulation of acetaldehyde after drinking as claimed in claim 4, wherein said sweetener is one or more of D-mannitol, xylitol, isomalt, sorbitol, high maltose flour, white sugar, and a mixture thereof in any ratio.
6. A method for producing a hydrogen-containing beverage for reducing accumulation of acetaldehyde after drinking as claimed in any one of claims 1 to 5, comprising the steps of:
step 1: purifying the active ingredient with water, and dissolving the extract in water;
step 2: adding auxiliary materials into the solution obtained in the step 1;
step 3: hydrogenation, fully and uniformly mixing, canning and sterilizing to obtain the hydrogen-containing beverage.
7. The method for producing a hydrogen-containing beverage for reducing accumulation of acetaldehyde after drinking as claimed in claim 6, wherein the concentration of hydrogen in the solution in step 3 is 1.2ppm.
8. The method for producing a hydrogen-containing beverage for reducing accumulation of acetaldehyde after drinking as claimed in claim 6, wherein said auxiliary material is xylitol.
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