CN117783570B - Detection mechanism and full-automatic thromboelastography appearance - Google Patents
Detection mechanism and full-automatic thromboelastography appearance Download PDFInfo
- Publication number
- CN117783570B CN117783570B CN202410210556.7A CN202410210556A CN117783570B CN 117783570 B CN117783570 B CN 117783570B CN 202410210556 A CN202410210556 A CN 202410210556A CN 117783570 B CN117783570 B CN 117783570B
- Authority
- CN
- China
- Prior art keywords
- cup
- detection
- reagent
- carrier
- driving
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000007246 mechanism Effects 0.000 title claims abstract description 145
- 238000001514 detection method Methods 0.000 title claims abstract description 77
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 77
- 238000003860 storage Methods 0.000 claims abstract description 45
- 238000002156 mixing Methods 0.000 claims abstract description 32
- 238000005070 sampling Methods 0.000 claims abstract description 31
- 238000000034 method Methods 0.000 claims abstract description 9
- 230000008569 process Effects 0.000 claims abstract description 7
- 239000000523 sample Substances 0.000 claims description 64
- 230000005540 biological transmission Effects 0.000 claims description 17
- 239000000725 suspension Substances 0.000 claims description 15
- 239000000969 carrier Substances 0.000 claims description 11
- 238000009434 installation Methods 0.000 claims description 10
- 239000002699 waste material Substances 0.000 claims description 9
- 238000012360 testing method Methods 0.000 claims description 8
- 238000005406 washing Methods 0.000 claims description 7
- 239000011259 mixed solution Substances 0.000 claims description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 3
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims 3
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 abstract description 5
- 208000007536 Thrombosis Diseases 0.000 abstract description 4
- 239000007788 liquid Substances 0.000 abstract description 2
- 238000003825 pressing Methods 0.000 description 9
- 238000001816 cooling Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 230000009471 action Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000003044 adaptive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000002091 elastography Methods 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Abstract
The invention relates to a detection mechanism and a full-automatic thromboelastography instrument, which belongs to the technical field of thromboelastography, and comprises an operation table fixed through a supporting beam, a sample storage mechanism, a reagent storage mechanism, a mixing mechanism, a reaction cup carrier, the detection mechanism, a sampling mechanism and a clamping mechanism, wherein the sample storage mechanism, the reagent storage mechanism, the mixing mechanism, the reaction cup carrier and the detection mechanism are connected to the operation table. In the full-automatic thromboelastography instrument provided by the invention, the detection mechanism is matched with the sampling mechanism capable of realizing inclined sample feeding, so that the whole structure of the mechanism is simple, the operation is convenient, and meanwhile, liquid splashing can be prevented in the inclined sample feeding process; the sample storage mechanism and the reagent storage mechanism are both provided with a uniform mixing structure and a corresponding heating or refrigerating structure, so that the equipment is more intelligent; and through mutually cooperating and matching among all mechanisms integrated in the housing, the full automation of thrombus elasticity detection can be realized, the detection efficiency is improved, and the interference of human factors is reduced.
Description
Technical Field
The invention relates to the technical field of thrombus elasticity detection, in particular to a detection mechanism and a full-automatic thrombus elastography instrument.
Background
Thromboelastography is a medical device that detects dynamic changes in blood coagulation, and is used to monitor and analyze the coagulation status of blood samples, thereby assisting in assessing the clinical hemostatic symptoms of a patient. The existing thromboelastography appearance is mostly equipment of model function singleness, needs artifical participation in the testing process to assist, leads to its detection efficiency low, and the human factor influences more to the testing result, can't satisfy the detection demand of the great user of demand. In particular, the existing structure of the detection unit is complex, for example, the patent of the invention with publication number CN116381261A, named as a full-automatic thromboelastography instrument discloses a self-positioning polymorphic implementation flow: the cup piece is put in motor one drive stretches out and receives sample pipe or sample cup, stretches out the in-process, and the tangent plane of locating piece and the laminating of the draw-in groove mouth of driven draw-in groove for the draw-in groove mouth of driven draw-in groove keeps unanimous after the locating piece stretches out, ensures that the locating piece stretches out the back and contracts still can be accurate target place, receives sample pipe or sample cup after, and the cup piece is put in motor one drive is retracted, makes the axis and the driven draw-in groove coincidence of locating piece. The detection scheme is provided with a cup placing block telescopic structure for receiving samples, and is also particularly provided with a matching structure for ensuring that the cup placing block can accurately return, and the scheme has more cost in equipment manufacturing and operation.
Disclosure of Invention
The invention aims to provide a detection mechanism and a full-automatic thromboelastography instrument, which can solve the technical problems in the background art.
In order to achieve the above purpose, the present invention provides the following technical solutions: the cup body bearing part comprises a base and an upper seat connected to the top end of the base, the upper seat and the base are matched to form an assembly cavity, a cup stand and a rotation driving motor for driving the cup stand to rotate are arranged in the assembly cavity, a push rod for bearing a reaction cup is arranged in the cup stand, and the bottom end of the push rod penetrates through the bottom of the base; the detection part is arranged above the cup bearing part and comprises an upper installation shell and a lower installation shell, a suspension wire is arranged in the upper installation shell, the suspension wire is connected with a detection probe through a thread bush, and the detection probe penetrates out from the bottom of the lower installation shell; the lifting driving part is connected with the cup bearing part and used for driving the cup bearing part to move towards the direction approaching or separating from the detection part.
As the preferable scheme, reset spring has been cup jointed to the push rod, reset spring's one end butt is in the saucer, and the other end is spacing through the baffle of installing on the push rod, reset spring is used for making the push rod reset.
As the preferred scheme, the output shaft eccentric connection who rotates driving motor has the spliced pole, one side of saucer is connected with actuating lever and fixes the transmission piece of cup joint on the actuating lever, the side butt of transmission piece is in the spliced pole, and the effect lies in the slight swing of drive saucer.
As the preferred scheme, go up installation casing top and be connected with the toper piece, the toper piece is connected with V-arrangement fixture block, be connected with the spliced pole among the top V-arrangement groove of V-arrangement fixture block, the top fixed connection of suspension wire in the spliced pole, through the V-arrangement groove can be spacing to the spliced pole, prevents its rotation.
The invention also provides a technical scheme of the full-automatic thromboelastography instrument, which comprises the detection mechanism, an operation table fixed through a supporting beam, a sample storage mechanism, a reagent storage mechanism, a mixing mechanism and a reaction cup carrier which are connected with the operation table, and a sampling mechanism and a clamping mechanism which are connected with the supporting beam.
As the preferred scheme, sample storage mechanism includes carrier fixed plate and sets up multiunit carrier guide slot on the carrier fixed plate, the carrier guide slot is used for fixed test tube carrier, the carrier fixed plate is connected with swing driving motor, swing driving motor is used for driving the swing of carrier fixed plate.
As the preferred scheme, reagent storage mechanism includes reagent position fixed plate, the one end of reagent position fixed plate is connected with the reagent carrier, the reagent carrier is equipped with two at least reagent carrier positions that are used for placing the reagent carrier, reagent position fixed plate still is connected with reagent driving motor, reagent driving motor is used for driving the reagent carrier rotation.
As a preferable scheme, the bottom end of the reagent carrier is connected with a refrigerating plate, and the reagent carrier is made of aluminum.
As a preferable scheme, the sampling mechanism comprises two groups of sampling needles and an inclined driving piece for driving the sampling needles to rotate, wherein the inclined driving piece comprises an inclined driving motor and a hollow rotating platform connected to the output end of the inclined driving motor, and the output end of the hollow rotating platform is connected with a rotating plate for connecting the sampling needles.
Preferably, the clamping mechanism comprises a clamping jaw which is horizontally arranged, has a preset length and is configured to extend between the cup body bearing part and the detection part.
Compared with the prior art, the invention has the beneficial effects that:
1. The detection mechanism provided by the invention has a simple overall structure, and the reaction cup can be taken and placed by arranging the push rod, so that the space can be more reasonably utilized. On the other hand, the detection mechanism is matched with the sample adding mechanism for inclined sample adding, an additional auxiliary matching structure is not required to be arranged in space, the operation is convenient, and meanwhile, splashing can be prevented in the inclined sample adding process;
2. According to the invention, the sample storage mechanism and the reagent storage mechanism are respectively provided with the uniform mixing structure and the corresponding heating or refrigerating structure, so that the device is more intelligent, and the detection efficiency is improved;
3. According to the invention, through mutual cooperative coordination among mechanisms integrated in the housing, full automation of thrombus elasticity detection can be realized, the detection efficiency is improved, and interference of human factors is reduced.
Drawings
FIG. 1 is a schematic view of the overall structure of a full-automatic thromboelastography machine according to an embodiment of the present invention;
FIG. 2 is a schematic view of the internal structure of a full-automatic thromboelastography machine according to an embodiment of the invention;
FIG. 3 is a top view of an operator's station according to an embodiment of the present invention;
FIG. 4 is a schematic structural diagram of a detection mechanism according to an embodiment of the present invention;
FIG. 5 is a top view of a detection mechanism according to an embodiment of the present invention;
FIG. 6 is a cross-sectional view taken along the direction A-A of FIG. 5;
FIG. 7 is a schematic diagram illustrating a transmission of a rotary drive motor according to an embodiment of the present invention;
FIG. 8 is a schematic diagram of a partial structure of a detecting portion according to an embodiment of the present invention;
FIG. 9 is a schematic view of a sample storage mechanism according to an embodiment of the present invention;
FIG. 10 is a top view of a reagent storage mechanism according to an embodiment of the present invention;
FIG. 11 is a cross-sectional view of FIG. 10 in the direction B-B;
FIG. 12 is a schematic diagram of a sample loading mechanism according to an embodiment of the present invention;
Fig. 13 is a schematic structural diagram of a clamping mechanism according to an embodiment of the invention.
The meaning of each reference sign in the figure is:
1. A housing; 101. a support beam; 102. an operation table; 103. an auxiliary table;
2. A detection mechanism; 201. a cup body bearing part; 2011. a base; 2012. an upper seat; 2013. a cup holder; 2014. a rotary drive motor; 2015. a motor mounting seat; 2016. rotating the column; 2017. a driving rod; 2018. a transmission block; 2019. a push rod; 2020. a return spring; 202. a detection unit; 2021. an upper mounting housing; 2022. a lower mounting housing; 2023. a conical block; 2024. a V-shaped clamping block; 2025. a suspension wire; 2026. a thread sleeve; 2027. detecting a probe; 2028. a fastener; 2029. a fan-shaped sheet; 2030. a circuit board; 2031. a pushing cover block; 2032. a push-cover motor; 2033. a sliding block; 2034. an adjusting nut; 2035. a compression spring; 203. a lifting driving part; 2036. a support base plate; 2037. a supporting top plate; 2038. a supporting vertical plate; 2039. a lifting driving motor; 2040. a ball screw; 2041. a driving block; 2042. a first transfer block; 2043. a second transfer block; 2044. a connecting column;
3. a sample storage mechanism; 301. a carrier fixing plate; 302. a test tube carrier; 303. a swing driving motor; 304. a support plate; 305. a supporting vertical seat; 306. a rotating lever; 307. a support block; 308. a housing; 309. a heating sheet;
4. A reagent storage mechanism; 401. a reagent position fixing plate; 402. a reagent carrier; 403. a reagent carrier; 404. a reagent driving motor; 405. a drive column; 406. a reagent carrier; 407. a cooling sheet; 408. a heat preservation layer;
5. a mixing mechanism; 501. mixing the carrier; 502. mixing evenly the carrying positions; 503. mixing the carriers;
6. A reaction cup carrier; 601. a reaction cup carrier;
7. A sample adding mechanism; 701. a sampling needle; 702. a first spatial control structure; 703. a tilt driving motor; 704. a hollow rotating platform; 705. a rotating plate;
8. a clamping mechanism; 801. a clamping jaw; 802. a second spatial control structure; 803. a pressing plate; 804. clamping the mounting plate; 805. pressing the driving piece;
9. a code scanner; 10. a needle washing mechanism; 11. and a waste cup collecting channel.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on the drawings are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the apparatus or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention.
Referring to fig. 4-8, the present embodiment discloses a detection mechanism 2 for a thromboelastography apparatus, which includes a cup bearing portion 201, a detection portion 202, and a lifting driving portion 203 for driving the cup bearing portion 201 to move up and down, where the cup bearing portion 201 is used for bearing a reaction cup and can drive the reaction cup to rotate, and the detection portion 202 is used for executing a detection action in cooperation with the reaction cup that moves up and down.
Referring to fig. 6, the cup bearing 201 includes a base 2011 and an upper base 2012 fixedly connected to a top end of the base 2011, and the base 2011 and the upper base 2012 cooperate to bear a cup holder 2013 disposed therein and a rotation driving motor 2014 for driving the cup holder 2013 to rotate. Specifically, the upper seat 2012 and the base 2011 are matched up and down to form an assembly cavity, the upper seat 2012 is provided with a first mounting hole for enabling the cup stand 2013 to extend out, the top end of the cup stand 2013 is provided with a hanging lug along the circumferential direction, and correspondingly, the top end of the first mounting hole is provided with a hanging groove matched with the hanging lug along the circumferential direction, and the cup stand 2013 is hung in the hanging groove through the hanging lug. The outer periphery of the cup holder 2013 is connected with a bearing and is rotatably connected with the upper seat 2012 through the bearing.
Referring to fig. 7, a rotation driving motor 2014 is fixedly connected to an upper seat 2012 through a motor mounting seat 2015, and is arranged on one side of a cup stand 2013 in parallel, an output shaft of the rotation driving motor 2014 is eccentrically connected with a rotation column 2016, a driving rod 2017 and a transmission block 2018 fixedly sleeved on the driving rod 2017 are correspondingly fixedly connected on one side of the cup stand 2013, the side surface of the transmission block 2018 is abutted to the rotation column 2016, and the transmission block 2018 and the driving rod 2017 can be driven to swing slightly through eccentric rotation of the rotation column 2016, so that the cup stand 2013 is driven to rotate slightly.
For the convenience of taking out the reaction cup in the cup stand 2013, in this embodiment, the cup body bearing part 201 further includes a push rod 2019 disposed in the cup stand 2013, the push rod 2019 includes a rod body and a push plate fixedly disposed at the top of the rod body, the push plate is used for receiving the reaction cup, the inner diameter of the cup stand 2013 is set to be wide in the upper part and narrow in the lower part corresponding to the diameters of the push plate and the rod body, an annular table surface for erecting the push plate is formed at the joint part of the push plate and the push rod body, the bottom end of the rod body penetrates out from the bottom of the cup stand 2013 and further penetrates out from the bottom of the base 2011, the reaction cup can be ejected by pushing the push rod 2019 upwards, and the push rod 2019 is automatically reset by a reset spring 2020. An annular groove for installing a baffle is formed in the rod body, the baffle is used for limiting one end of the reset spring 2020, the reset spring 2020 is sleeved on the rod body, and the other end of the reset spring 2020 is connected to the bottom end of the cup stand 2013. When pushing force is applied to the push rod 2019, the restoring spring 2020 can be compressed, and when pushing force is released, the restoring spring 2020 drives the push rod 2019 to restore.
Referring to fig. 4, in the present embodiment, the elevation driving part 203 is connected to the support top plate 2037 through a support bottom plate 2036 disposed in parallel, and the support bottom plate 2036 is disposed below the cup bearing part 201. The lifting driving part 203 comprises a supporting vertical plate 2038 fixedly connected between a supporting bottom plate 2036 and a supporting top plate 2037, wherein the supporting vertical plate 2038 is vertically arranged, and is fixedly connected with a sliding rail and a sliding block in sliding fit with the sliding rail along the vertical direction. The lifting driving part 203 further includes a lifting driving motor 2039 fixedly connected to the top end of the supporting top plate 2037, and a ball screw 2040 fixedly connected to the output end of the lifting driving motor 2039, a driving block 2041 is fixedly connected to the nut end of the ball screw 2040, the driving block 2041 is fixedly connected to the slider, and two sides thereof are fixedly connected to first adapter blocks 2042, and the first adapter blocks 2042 are fixedly connected to a motor mounting seat 2015 in the upper seat 2012 through second adapter blocks 2043.
The cup bearing part 201 can be driven to move up and down along the sliding rail by driving the lifting driving motor 2039, and when the cup bearing part 201 moves towards the direction close to the supporting bottom plate 2036, the acting force of the supporting bottom plate 2036 on the push rod 2019 can push out the reaction cup.
Referring to fig. 6 and 8, the detecting portion 202 is disposed above the cup bearing portion 201, and includes an upper mounting housing 2021 and a lower mounting housing 2022, the upper mounting housing 2021 is fixedly connected to an upper portion of the supporting top plate 2037 through a mounting plate, and the lower mounting housing 2022 is fixedly connected to a lower portion of the supporting top plate 2037. The detecting part 202 further comprises a conical block 2023 fixedly connected to the top end of the upper mounting shell 2021, and a V-shaped clamping block 2024 mounted through the conical block 2023, wherein a V-shaped groove is formed in the top of the V-shaped clamping block 2024, a suspension wire 2025 is connected to the middle lower portion of the V-shaped clamping block 2024 through the conical block 2023, a channel matched with the suspension wire 2025 is formed in the center of the V-shaped clamping block 2024, the top end of the suspension wire 2025 is fixedly connected to a connecting column 2044 in the V-shaped groove, the bottom end of the suspension wire is fixedly connected with a detecting probe 2027 through a threaded sleeve 2026, the top end of the detecting probe 2027 is connected to the bottom of the threaded sleeve 2026 through a connecting pin, and the bottom end of the detecting probe 2027 penetrates out from the bottom of the lower mounting shell 2022 and is used for being inserted into a cup cover of a reaction cup. The connection structure between the bottom end of the suspension wire 2025 and the thread sleeve 2026 is specifically configured such that the upper end portion of the thread sleeve 2026 is provided with a long hole matching with the bottom of the suspension wire 2025, and the long hole is provided with an opening along the height direction thereof, so that the thread sleeve 2026 can clamp the suspension wire 2025 through the fastener 2028 sleeved on the upper end of the thread sleeve 2026.
The screw sleeve 2026 is further connected with two fan-shaped pieces 2029 for detecting the rotation angle of the detection probe 2027 and a circuit board 2030 arranged between the two fan-shaped pieces 2029, the two fan-shaped pieces 2029 cut a magnetic field of the circuit board 2030 in the middle in the rotation process, and the thromboelastography is drawn according to the generated electric signals.
In order to facilitate automatic cap removal of the cap on the detection probe 2027, the detection portion 202 further includes a cap pushing block 2031 sleeved at the middle lower portion of the detection probe 2027, and a cap pushing driving member for driving the cap pushing block 2031 to move, where the cap pushing driving member includes a cap pushing motor 2032 fixedly connected to the lower mounting housing 2022, and a sliding block 2033 connected to an output end of the cap pushing motor 2032, in this embodiment, the cap pushing motor 2032 adopts a through shaft type linear stepping motor, the sliding block 2033 is provided with an opening with a predetermined length, and the detection probe 2027 passes through the opening. The sliding block 2033 can be driven to reciprocate through the cover pushing motor 2032, the sliding block 2033 and the cover pushing block 2031 are respectively provided with corresponding slopes, and the sliding block 2033 can push the cover pushing block 2031 to descend in the moving process of the sliding block 2033 so as to push out the cup cover.
To facilitate the height adjustment of the probe and ensure the consistency of the detection, in this embodiment, the detecting portion 202 further includes an adjusting member for adjusting the height of the detecting probe 2027, where the adjusting member includes an adjusting nut 2034 screwed on the tapered block 2023, the adjusting nut 2034 is pressed on the V-shaped block 2024, and a compression spring 2035 for applying an upward force to the V-shaped block 2024 is sleeved on the periphery of the V-shaped block. The height of the V-shaped block 2024, and thus the suspension wire 2025 and the detection probe 2027, can be adjusted by screwing the adjustment nut 2034.
Based on the detection mechanism 2 provided in the above embodiment, the present embodiment further provides a full-automatic thromboelastography apparatus, referring to fig. 1-3, the apparatus further includes a sample storage mechanism 3, a reagent storage mechanism 4, a mixing mechanism 5, a reaction cup carrier 6, a sample adding mechanism 7, and a clamping mechanism 8, where each mechanism is integrated in the housing 1 fixed by the support beam 101, and each mechanism cooperates to implement full-automatic operation.
Specifically, the fully automatic thromboelastography apparatus includes an operation table 102 and an auxiliary table 103 connected by a support beam 101, and the auxiliary table 103 is disposed below the operation table 102 for assisting in the arrangement of structures. The sample storage mechanism 3, the reagent storage mechanism 4, the mixing mechanism 5 and the cuvette carrier 6 are all connected to the operation table 102, and the support base plate 2036 in the detection mechanism 2 is fixedly connected to the auxiliary table 103 via support columns.
Referring to fig. 3 and 9, the operation table 102 is provided with a mounting frame adapted to the sample storage mechanism 3, and the sample storage mechanism 3 is disposed in the mounting frame, and includes a carrier fixing plate 301 disposed along the Y direction and a plurality of groups of carrier guide grooves disposed above the carrier fixing plate 301 along the Y direction, and a test tube carrier 302 for loading a sample test tube can be pushed into the carrier guide grooves. In order to facilitate the mixing of the samples, in this embodiment, the sample storage mechanism 3 further includes a swing driving motor 303 for driving the carrier fixing plate 301 to swing, specifically, a supporting plate 304 for supporting is disposed below the carrier fixing plate 301, and the supporting plate 304 is fixedly connected to the auxiliary table 103. The top end of the supporting plate 304 is fixedly connected with two supporting stand seats 305, a rotating rod 306 is rotatably connected between the two supporting stand seats 305 through a bearing, a plurality of groups of supporting blocks 307 are fixedly connected with the bottom end of the carrier fixing plate 301 correspondingly, through holes for the rotating rod 306 to pass through are formed in the bottoms of the supporting blocks 307, and the rotating rod 306 and the through holes can be connected through keys. The swing driving motor 303 is fixedly arranged on the supporting plate 304, is connected to one end of the rotating rod 306 through a transmission structure and is used for driving the rotating rod 306 to swing, and the supporting block 307 and the carrier fixing plate 301 can be driven to swing synchronously through the swing of the rotating rod 306, so that the effect of uniformly mixing samples is achieved.
To accelerate the mixing of the samples, the sample storage mechanism 3 in this embodiment further includes a housing 308 fixedly connected to the carrier fixing plate 301, the housing 308 covers both sides and top ends of the test tube carrier 302, and a heating plate 309 for heating is connected to an inner wall of the housing 308.
Referring to fig. 10 and 11, the reagent storage mechanism 4 is disposed on one side of the sample storage mechanism 3, and includes a reagent position fixing plate 401, one end of the reagent position fixing plate 401 is connected with a reagent carrier 402, and the reagent carrier 402 is provided with at least two reagent carrying positions 403 for placing different reagent carriers 406. In order to facilitate the uniform mixing of the reagents, the reagent storage mechanism 4 further comprises a reagent driving motor 404 for driving one of the reagent carriers 406 to rotate, the reagent driving motor 404 is fixedly connected to the other end of the reagent position fixing plate 401, a transmission column 405 is connected to the reagent position fixing plate through a transmission structure, the transmission column 405 penetrates from the bottom of the reagent position fixing plate 401 and is rotationally connected with the reagent position fixing plate, and the transmission column 405 extends into the reagent carrier position 403. The bottom end of the corresponding reagent carrier 406 is provided with a connecting groove for connecting the transmission column 405, and the reagent carrier 406 is driven to rotate by the rotation of the transmission column 405.
In this embodiment, the reagent storage mechanism 4 further includes a cooling plate 407 for cooling the reagent, the cooling plate 407 is fixedly connected to the bottom end of the reagent carrier 402, in order to ensure the transmission of the cooling effect, the reagent carrier 402 is preferably made of aluminum, and an insulating layer 408 is disposed on the periphery of the reagent carrier 402.
Referring to fig. 3, the mixing mechanism 5 includes a mixing carrier 501 fixedly connected to the console 102, and a plurality of mixing carriers 502 for connecting the mixing carriers 503 are disposed on the mixing carrier 501, where the structural arrangement of the mixing carriers 502 can be diversified to match with different carriers or detection requirements.
Referring to fig. 3, the cuvette carrier 6 is fixedly connected to the console 102, and a cuvette carrier position for connecting with the cuvette carrier 601 is provided at the top end of the cuvette carrier 6, and the cuvette carriers 6 may be arranged into multiple groups according to the detection requirement.
Referring to fig. 12, the sample application mechanism 7 is connected by a support beam 101 and includes two sets of sampling pins 701 for sampling samples and reagents, respectively, and a first spatial control structure 702 for controlling the sampling pins 701 to perform X-direction, Y-direction, and Z-direction movements, respectively, the first spatial control structure 702 belonging to the prior art. The sampling needle 701 is connected with a corresponding sample adding pump, samples and reagents are respectively sampled through the sampling mechanism 7 and transferred to the mixing mechanism 5 for mixing, and then the mixed solution is transferred to a reaction cup of the detection mechanism 2 through the sampling needle 701.
It should be noted that, in order to match the orientations of the cup bearing portion 201 and the detecting portion 202 in the detecting mechanism 2, the sampling needle 701 needs to be inclined for sampling, so in this embodiment, the sampling mechanism 7 further includes an inclined driving member for driving the sampling needle 701 to rotate, the inclined driving member includes an inclined driving motor 703 and a hollow rotating platform 704 connected to an output end thereof, and an output end of the hollow rotating platform 704 is fixedly connected with a rotating plate 705 for connecting the sampling needle 701, where the hollow rotating platform 704 is fixedly connected to the first space control structure 702 through an adapter plate. When the sample needs to be added into the reaction cup, the sampling needle 701 is driven by the inclined driving piece to incline to an adaptive angle, so that the mixed solution is added into the reaction cup in an inclined mode, and meanwhile, the liquid can be prevented from splashing by the inclined sample.
The clamping mechanism 8 is used for clamping and conveying the reaction cup, and referring to fig. 13, the clamping mechanism 8 includes a clamping jaw 801 and a second space control structure 802 for controlling the clamping jaw 801 to move in X direction, Y direction and Z direction respectively, and the second space control structure 802 belongs to the prior art. In this embodiment, the clamping jaw 801 is disposed along a horizontal direction and has a predetermined length, and can extend between the cup bearing portion 201 and the detecting portion 202 to take and place the reaction cup. In order to ensure stable transportation of the reaction cup, the clamping mechanism further comprises a pressing plate 803 arranged above the clamping jaw 801, the pressing plate 803 and the clamping jaw 801 are connected through a clamping mounting plate 804, the pressing plate 803 is connected with a pressing driving piece 805 for controlling lifting movement of the pressing plate 803, and the pressing plate 803 is driven to move towards a direction close to or far away from the clamping jaw 801 through the pressing driving piece 805 so as to press the reaction cup.
In this embodiment, the full-automatic thrombelastogram instrument further includes a code scanner 9 for scanning a sample tube, a needle washing mechanism 10 for washing a sampling needle 701, and a waste cup collecting channel 11 for collecting waste reaction cups, which are well known in the art, and are not described in detail in this embodiment.
Based on the full-automatic thromboelastography apparatus provided in the above embodiment, another embodiment further provides a full-automatic thromboelastography method, including the following steps:
S1, manually adding a sample and a reagent to corresponding positions of a sample storage mechanism 3 and a reagent storage mechanism 4;
S2, respectively adding a sample and a reagent into the mixing mechanism 5 by the sampling mechanism 7 for mixing;
s3, clamping the reaction cup in the reaction cup carrier 6 into the cup bearing part 201 of the detection mechanism 2 by the clamping mechanism 8, wherein the cup bearing part 201 moves upwards, the cup cover of the reaction cup is pricked into the detection probe 2027, and the cup bearing part 201 moves downwards;
S4, the mixed solution is obliquely added into a reaction cup of the detection mechanism 2 by the sampling mechanism 7, the cup body bearing part 201 ascends, and a detection column on the cup cover extends into the cup body to start detection operation;
S5, after the detection is finished, the detection probe 2027 is uncapped, the cup bearing part 201 descends, and the reaction cup is transported to the waste cup collecting channel 11 by the clamping mechanism 8.
It can be understood that the above-mentioned action processes are all controlled by the control module, and the control module can specifically include a control chip or a single chip microcomputer which can control the above-mentioned mechanisms according to a predetermined program, so that the whole equipment can be started, stopped or perform other actions according to a preset flow.
The foregoing has shown and described the basic principles, principal features and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the above-described embodiments, and that the above-described embodiments and descriptions are only preferred embodiments of the present invention, and are not intended to limit the invention, and that various changes and modifications may be made therein without departing from the spirit and scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (8)
1. A full-automatic thromboelastography machine is characterized in that,
The cup body detection device comprises a detection mechanism, wherein the detection mechanism comprises a cup body bearing part (201) and a detection part (202), the detection part (202) is arranged above the cup body bearing part (201), the cup body bearing part (201) comprises a base (2011) and an upper seat (2012) connected to the top end of the base (2011), the upper seat (2012) and the base (2011) are matched to form an assembly cavity, a cup holder (2013) and a rotation driving motor (2014) for driving the cup holder (2013) to rotate are arranged in the assembly cavity, a push rod (2019) for bearing a reaction cup is arranged in the cup holder (2013), and the bottom end of the push rod (2019) penetrates through the bottom of the base (2011); the detection part (202) comprises an upper installation shell (2021) and a lower installation shell (2022), a suspension wire (2025) is arranged in the upper installation shell (2021), the suspension wire (2025) is connected with a detection probe (2027) through a threaded sleeve (2026), and the detection probe (2027) penetrates out from the bottom of the lower installation shell (2022); the detection mechanism further comprises a lifting driving part (203), wherein the lifting driving part (203) is connected to the cup body bearing part (201) and is used for driving the cup body bearing part (201) to move towards or away from the detection part (202);
The detection part (202) further comprises a pushing cover block (2031) sleeved at the middle lower part of the detection probe (2027), and a pushing cover driving piece used for driving the pushing cover block (2031) to move, wherein the pushing cover driving piece comprises a pushing cover motor (2032) fixedly connected with the lower installation shell (2022) and a sliding block (2033) connected with the output end of the pushing cover motor (2032), the sliding block (2033) is provided with an opening with a preset length, the detection probe (2027) penetrates through the opening, the sliding block (2033) and the pushing cover block (2031) are respectively provided with corresponding slopes, and the sliding block (2033) is pushed to move downwards in the moving process of the sliding block (2031);
The device also comprises an operation table (102) and an auxiliary table (103) which are fixed through a supporting beam (101), wherein the auxiliary table (103) is arranged below the operation table (102) and used for arranging an auxiliary structure, a sample storage mechanism (3), a reagent storage mechanism (4), a mixing mechanism (5), a reaction cup carrier (6), a code scanner (9), a needle washing mechanism (10), a waste cup collecting channel (11) and a sterilizing mechanism, the device also comprises a sample adding mechanism (7) and a clamping mechanism (8) which are connected to the supporting beam (101), the sample adding mechanism and the clamping mechanism are arranged above the operation table (102), the sample storage mechanism (3) is arranged on the left side of the operation table, the front of the sample storage mechanism is provided with the code scanner (9), a sterilizing mechanism and a needle washing mechanism (10) are respectively arranged on the front and back of the right side of the sample storage mechanism (3), the right side of the sterilizing mechanism and the needle washing mechanism (10) is provided with the reagent storage mechanism (4), the right upper side of the reagent storage mechanism (4) is close to one side of a detection mechanism (2) which is arranged on the right side of the detecting mechanism (4), the waste cup collecting mechanism (11) is arranged on the right side of the mixing mechanism (4), the right side of the waste cup collecting mechanism (4) is arranged on the right side of the mixing mechanism (5), the detection mechanism (2) is positioned behind the sample storage mechanism (3), the reagent storage mechanism (4), the mixing mechanism (5), the reaction cup carrier (6), the code scanner (9), the needle washing mechanism (10), the waste cup collecting channel (11) and the disinfection mechanism;
the heights of the sample storage mechanism (3), the reaction cup carrier (6) and the reagent storage mechanism (4) are higher than those of the mixing mechanism (5);
the sampling mechanism (7) is positioned at the left side of the clamping mechanism (8), and the sampling mechanism (7) and the clamping mechanism (8) are positioned on the same track;
The sampling mechanism (7) comprises two groups of sampling needles (701) and an inclined driving piece for driving the sampling needles (701) to rotate, wherein the inclined driving piece comprises an inclined driving motor (703) and a hollow rotary platform (704) connected with the output end of the inclined driving motor, and the output end of the hollow rotary platform (704) is connected with a rotary plate (705) for connecting the sampling needles (701);
The full-automatic thromboelastography detection method comprises the following steps:
s1, manually adding a sample and a reagent to corresponding positions of a sample storage mechanism (3) and a reagent storage mechanism (4);
s2, respectively adding a sample and a reagent into a mixing mechanism (5) by a sampling mechanism (7) for mixing;
s3, clamping the reaction cup in the reaction cup carrier (6) into a cup bearing part (201) of the detection mechanism (2) by a clamping mechanism (8), wherein the cup bearing part (201) ascends, the detection probe (2027) is pricked into a cup cover of the reaction cup, and the cup bearing part (201) descends;
S4, the mixed solution is obliquely added into a reaction cup of the detection mechanism (2) by the sampling mechanism (7), the cup body bearing part (201) ascends, and a detection column on the cup cover stretches into the cup body to start detection operation;
S5, after the detection is finished, the detection probe (2027) is uncapped, the cup body bearing part (201) descends, and the reaction cup is transported to the waste cup collecting channel (11) by the clamping mechanism (8).
2. The fully automatic thromboelastography machine of claim 1, wherein,
The push rod (2019) is sleeved with a reset spring (2020), one end of the reset spring (2020) is abutted to the cup stand (2013), and the other end of the reset spring is limited through a baffle plate arranged on the push rod (2019).
3. The fully automatic thromboelastography machine of claim 1, wherein,
An output shaft of the rotation driving motor (2014) is eccentrically connected with a rotation column (2016), one side of the cup stand (2013) is connected with a driving rod (2017) and a transmission block (2018) fixedly sleeved on the driving rod (2017), and the side face of the transmission block (2018) is abutted to the rotation column (2016).
4. The fully automatic thromboelastography machine of claim 1, wherein,
The top of the upper mounting shell (2021) is connected with a conical block (2023), the conical block (2023) is connected with a V-shaped clamping block (2024), a connecting column (2044) is connected in a V-shaped groove at the top of the V-shaped clamping block (2024), and the top end of the suspension wire (2025) is fixedly connected with the connecting column (2044).
5. The fully automatic thromboelastography machine of claim 1, wherein,
The sample storage mechanism (3) comprises a carrier fixing plate (301) and a plurality of groups of carrier guide grooves arranged on the carrier fixing plate (301), wherein the carrier guide grooves are used for fixing test tube carriers (302), the carrier fixing plate (301) is connected with a swing driving motor (303), and the swing driving motor (303) is used for driving the carrier fixing plate (301) to swing.
6. The fully automatic thromboelastography machine of claim 1, wherein,
The reagent storage mechanism (4) comprises a reagent position fixing plate (401), one end of the reagent position fixing plate (401) is connected with a reagent carrier (402), the reagent carrier (402) is provided with at least two reagent carrying positions (403) for placing reagent carriers (406), the reagent position fixing plate (401) is further connected with a reagent driving motor (404), and the reagent driving motor (404) is used for driving the reagent carriers (406) to rotate.
7. The fully automatic thromboelastography machine of claim 6, wherein,
The bottom of the reagent carrier (402) is connected with a refrigerating plate (407), and the reagent carrier (402) is made of aluminum.
8. The fully automatic thromboelastography machine of claim 1, wherein,
The clamping mechanism (8) comprises a clamping jaw (801) which is horizontally arranged, wherein the clamping jaw (801) has a preset length and is configured to extend between the cup body bearing part (201) and the detection part (202).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410210556.7A CN117783570B (en) | 2024-02-27 | Detection mechanism and full-automatic thromboelastography appearance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410210556.7A CN117783570B (en) | 2024-02-27 | Detection mechanism and full-automatic thromboelastography appearance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN117783570A CN117783570A (en) | 2024-03-29 |
| CN117783570B true CN117783570B (en) | 2024-05-31 |
Family
ID=
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106124786A (en) * | 2016-08-10 | 2016-11-16 | 浙江盛域医疗技术有限公司 | A kind of thrombosis semi-automatic elastic force figure instrument |
| CN207882287U (en) * | 2018-01-09 | 2018-09-18 | 深圳拓真生物科技有限公司 | Reaction cup transfer mechanism |
| CN209496044U (en) * | 2018-10-29 | 2019-10-15 | 苏州新波生物技术有限公司 | A kind of transfer device of reaction cup and equipment containing the transfer device |
| CN213222270U (en) * | 2020-08-31 | 2021-05-18 | 浙江盛域医疗技术有限公司 | Constant temperature platform and blood specimen detection device of thrombelastogram appearance |
| CN214408987U (en) * | 2021-01-25 | 2021-10-15 | 深圳优迪生物技术有限公司 | Automatic testing device of thrombelastogram instrument |
| CN113791235A (en) * | 2021-11-18 | 2021-12-14 | 深圳优迪生物技术有限公司 | Full-automatic thromboelastogram instrument and blood sample testing method |
| EP3943935A1 (en) * | 2019-03-29 | 2022-01-26 | Hemoassay Science and Technology (Suzhou) Co., Ltd. | Fully-automatic thromboelastography testing device and testing method |
| CN215905398U (en) * | 2021-07-27 | 2022-02-25 | 深圳市爱康生物科技股份有限公司 | Reaction cup tongs device |
| CN114558629A (en) * | 2022-03-03 | 2022-05-31 | 四川微康朴澜医疗科技有限责任公司 | Microfluidic thrombus elasticity analysis and detection kit |
| CN114814250A (en) * | 2022-04-12 | 2022-07-29 | 江苏安准医疗科技有限公司 | Automatic unload thrombelastogram appearance of cup |
| CN116381261A (en) * | 2023-05-19 | 2023-07-04 | 重庆康巨全弘生物科技有限公司 | Full-automatic thromboelastography appearance |
| CN116660562A (en) * | 2023-05-19 | 2023-08-29 | 重庆康巨全弘生物科技有限公司 | Full-automatic thrombus elastography detection method |
| CN117031048A (en) * | 2023-07-04 | 2023-11-10 | 厦门宝太生物科技股份有限公司 | Full-automatic homogeneous phase chemiluminescence detector and testing method |
Patent Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106124786A (en) * | 2016-08-10 | 2016-11-16 | 浙江盛域医疗技术有限公司 | A kind of thrombosis semi-automatic elastic force figure instrument |
| CN207882287U (en) * | 2018-01-09 | 2018-09-18 | 深圳拓真生物科技有限公司 | Reaction cup transfer mechanism |
| CN209496044U (en) * | 2018-10-29 | 2019-10-15 | 苏州新波生物技术有限公司 | A kind of transfer device of reaction cup and equipment containing the transfer device |
| EP3943935A1 (en) * | 2019-03-29 | 2022-01-26 | Hemoassay Science and Technology (Suzhou) Co., Ltd. | Fully-automatic thromboelastography testing device and testing method |
| CN213222270U (en) * | 2020-08-31 | 2021-05-18 | 浙江盛域医疗技术有限公司 | Constant temperature platform and blood specimen detection device of thrombelastogram appearance |
| CN214408987U (en) * | 2021-01-25 | 2021-10-15 | 深圳优迪生物技术有限公司 | Automatic testing device of thrombelastogram instrument |
| CN215905398U (en) * | 2021-07-27 | 2022-02-25 | 深圳市爱康生物科技股份有限公司 | Reaction cup tongs device |
| CN113791235A (en) * | 2021-11-18 | 2021-12-14 | 深圳优迪生物技术有限公司 | Full-automatic thromboelastogram instrument and blood sample testing method |
| CN217466952U (en) * | 2021-11-18 | 2022-09-20 | 深圳优迪生物技术有限公司 | Full-automatic thrombelastogram instrument |
| CN114558629A (en) * | 2022-03-03 | 2022-05-31 | 四川微康朴澜医疗科技有限责任公司 | Microfluidic thrombus elasticity analysis and detection kit |
| CN114814250A (en) * | 2022-04-12 | 2022-07-29 | 江苏安准医疗科技有限公司 | Automatic unload thrombelastogram appearance of cup |
| CN116381261A (en) * | 2023-05-19 | 2023-07-04 | 重庆康巨全弘生物科技有限公司 | Full-automatic thromboelastography appearance |
| CN116660562A (en) * | 2023-05-19 | 2023-08-29 | 重庆康巨全弘生物科技有限公司 | Full-automatic thrombus elastography detection method |
| CN117031048A (en) * | 2023-07-04 | 2023-11-10 | 厦门宝太生物科技股份有限公司 | Full-automatic homogeneous phase chemiluminescence detector and testing method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110398600B (en) | Automatic mixing device of blood sample and blood cell analysis equipment | |
| JPH0611512A (en) | Automatic apparatus for analyzing blood group | |
| CN113800450B (en) | Cover opening and closing device for full-automatic blood sampling tube | |
| CN110018320A (en) | A kind of detection driving device and driving method | |
| CN211292271U (en) | Test tube liquid sample mixing mechanism and device | |
| CN112180106A (en) | Puncture liquid feeding mixing machine | |
| CN117783570B (en) | Detection mechanism and full-automatic thromboelastography appearance | |
| CN111537758A (en) | Porous automatic sample introduction device and sample introduction method | |
| CN207923902U (en) | Blood type card sting device and blood type analytical instrument | |
| CN117783570A (en) | Detection mechanism and full-automatic thromboelastography appearance | |
| CN113634170B (en) | Shaking-up device for full-automatic blood collection tube | |
| CN113797818B (en) | Full-automatic heparin tube switch lid and shake even device | |
| CN216594779U (en) | Automatic sample adding device for fluorescence detector | |
| CN115839872A (en) | Full-automatic liquid-based cell slice-making dyeing machine | |
| CN210775522U (en) | Colloidal gold fluorescence integrated immunoassay instrument | |
| CN115453029A (en) | Automatic sample adding chromatographic analyzer and detection method thereof | |
| CN112834316A (en) | Be used for blood test to use homogeneous mixing device | |
| CN112539987A (en) | Test tube liquid sample mixing mechanism and device | |
| CN215778094U (en) | Intelligent blood sampling robot | |
| CN219777704U (en) | Full-automatic thromboelastography appearance | |
| CN216879038U (en) | Heparin tube sways device | |
| CN114486425A (en) | Continuous sheet pushing device of sheet pushing machine | |
| CN219816043U (en) | Mixing device for automatically dripping blood group reagent | |
| CN217878547U (en) | Continuous sheet pushing device of sheet pushing machine | |
| CN113759143B (en) | Novel full-automatic tissue chip instrument |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant |