CN117769408A - 双相化妆品组合物及其应用 - Google Patents
双相化妆品组合物及其应用 Download PDFInfo
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- CN117769408A CN117769408A CN202280031997.XA CN202280031997A CN117769408A CN 117769408 A CN117769408 A CN 117769408A CN 202280031997 A CN202280031997 A CN 202280031997A CN 117769408 A CN117769408 A CN 117769408A
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- China
- Prior art keywords
- cosmetic composition
- sulfate
- sodium
- ether
- ppg
- Prior art date
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- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 169
- 239000002537 cosmetic Substances 0.000 title claims abstract description 125
- 239000012071 phase Substances 0.000 claims abstract description 125
- 230000002051 biphasic effect Effects 0.000 claims abstract description 38
- 239000004480 active ingredient Substances 0.000 claims abstract description 32
- 239000008346 aqueous phase Substances 0.000 claims abstract description 21
- 239000000839 emulsion Substances 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 14
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 85
- -1 polyoxypropylene Polymers 0.000 claims description 85
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 82
- 230000009977 dual effect Effects 0.000 claims description 72
- 150000002191 fatty alcohols Chemical class 0.000 claims description 69
- 229920006395 saturated elastomer Polymers 0.000 claims description 40
- 239000003921 oil Substances 0.000 claims description 39
- 235000019198 oils Nutrition 0.000 claims description 38
- 239000003945 anionic surfactant Substances 0.000 claims description 34
- 150000002430 hydrocarbons Chemical class 0.000 claims description 34
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 30
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 29
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 28
- 239000011734 sodium Substances 0.000 claims description 25
- 125000004432 carbon atom Chemical group C* 0.000 claims description 24
- 125000000913 palmityl group Chemical class [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 24
- 229910052708 sodium Inorganic materials 0.000 claims description 23
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 19
- 239000000194 fatty acid Substances 0.000 claims description 19
- 229930195729 fatty acid Natural products 0.000 claims description 19
- 229940104261 taurate Drugs 0.000 claims description 19
- 239000002280 amphoteric surfactant Substances 0.000 claims description 18
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 16
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 150000002148 esters Chemical class 0.000 claims description 14
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical class CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 claims description 13
- 150000004665 fatty acids Chemical class 0.000 claims description 13
- 239000004094 surface-active agent Substances 0.000 claims description 13
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 12
- 150000002170 ethers Chemical class 0.000 claims description 11
- 229910052700 potassium Inorganic materials 0.000 claims description 11
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical group CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims description 10
- 150000001298 alcohols Chemical class 0.000 claims description 10
- 229930195733 hydrocarbon Natural products 0.000 claims description 10
- 229920000570 polyether Polymers 0.000 claims description 10
- 229920002545 silicone oil Polymers 0.000 claims description 10
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 9
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 9
- 239000011591 potassium Substances 0.000 claims description 9
- XMVBHZBLHNOQON-UHFFFAOYSA-N 2-butyl-1-octanol Chemical compound CCCCCCC(CO)CCCC XMVBHZBLHNOQON-UHFFFAOYSA-N 0.000 claims description 8
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 8
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 7
- 229940057950 sodium laureth sulfate Drugs 0.000 claims description 7
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 6
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 claims description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 6
- QGLITUFXHVRMGV-UHFFFAOYSA-M sodium;tetratriacontyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCOS([O-])(=O)=O QGLITUFXHVRMGV-UHFFFAOYSA-M 0.000 claims description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 5
- 229940024606 amino acid Drugs 0.000 claims description 5
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 229940009098 aspartate Drugs 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 229940071089 sarcosinate Drugs 0.000 claims description 5
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 claims description 5
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 4
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 claims description 4
- XULHFMYCBKQGEE-UHFFFAOYSA-N 2-hexyl-1-Decanol Chemical compound CCCCCCCCC(CO)CCCCCC XULHFMYCBKQGEE-UHFFFAOYSA-N 0.000 claims description 4
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 4
- 239000004215 Carbon black (E152) Chemical class 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 4
- 229960000541 cetyl alcohol Drugs 0.000 claims description 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 4
- 239000008240 homogeneous mixture Substances 0.000 claims description 4
- BOUCRWJEKAGKKG-UHFFFAOYSA-N n-[3-(diethylaminomethyl)-4-hydroxyphenyl]acetamide Chemical compound CCN(CC)CC1=CC(NC(C)=O)=CC=C1O BOUCRWJEKAGKKG-UHFFFAOYSA-N 0.000 claims description 4
- 229940055577 oleyl alcohol Drugs 0.000 claims description 4
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 4
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 4
- 229940012831 stearyl alcohol Drugs 0.000 claims description 4
- AZLWQVJVINEILY-UHFFFAOYSA-N 2-(2-dodecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCOCCOCCO AZLWQVJVINEILY-UHFFFAOYSA-N 0.000 claims description 3
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 3
- 239000010775 animal oil Substances 0.000 claims description 3
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 3
- 229930195712 glutamate Natural products 0.000 claims description 3
- 125000005456 glyceride group Chemical group 0.000 claims description 3
- 229940031726 laureth-10 Drugs 0.000 claims description 3
- 229940100491 laureth-2 Drugs 0.000 claims description 3
- 239000002480 mineral oil Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000010690 paraffinic oil Substances 0.000 claims description 3
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 3
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 3
- 239000008158 vegetable oil Substances 0.000 claims description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 2
- CYPKANIKIWLVMF-UHFFFAOYSA-N 2-[(2-oxo-3,4-dihydro-1h-quinolin-5-yl)oxy]acetic acid Chemical compound N1C(=O)CCC2=C1C=CC=C2OCC(=O)O CYPKANIKIWLVMF-UHFFFAOYSA-N 0.000 claims description 2
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 claims description 2
- LIFHMKCDDVTICL-UHFFFAOYSA-N 6-(chloromethyl)phenanthridine Chemical compound C1=CC=C2C(CCl)=NC3=CC=CC=C3C2=C1 LIFHMKCDDVTICL-UHFFFAOYSA-N 0.000 claims description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 2
- ARIWANIATODDMH-UHFFFAOYSA-N Lauric acid monoglyceride Natural products CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 claims description 2
- FOUZISDNESEYLX-UHFFFAOYSA-N N-hydroxyethyl glycine Natural products OCCNCC(O)=O FOUZISDNESEYLX-UHFFFAOYSA-N 0.000 claims description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 2
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 claims description 2
- 229940063953 ammonium lauryl sulfate Drugs 0.000 claims description 2
- FMBMJZOGMAKBLM-UHFFFAOYSA-N azane;sulfo dodecanoate Chemical compound [NH4+].CCCCCCCCCCCC(=O)OS([O-])(=O)=O FMBMJZOGMAKBLM-UHFFFAOYSA-N 0.000 claims description 2
- 229960003237 betaine Drugs 0.000 claims description 2
- MKHVZQXYWACUQC-UHFFFAOYSA-N bis(2-hydroxyethyl)azanium;dodecyl sulfate Chemical compound OCCNCCO.CCCCCCCCCCCCOS(O)(=O)=O MKHVZQXYWACUQC-UHFFFAOYSA-N 0.000 claims description 2
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims description 2
- 229940079868 disodium laureth sulfosuccinate Drugs 0.000 claims description 2
- YGAXLGGEEQLLKV-UHFFFAOYSA-L disodium;4-dodecoxy-4-oxo-2-sulfonatobutanoate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOC(=O)CC(C([O-])=O)S([O-])(=O)=O YGAXLGGEEQLLKV-UHFFFAOYSA-L 0.000 claims description 2
- QVBODZPPYSSMEL-UHFFFAOYSA-N dodecyl sulfate;2-hydroxyethylazanium Chemical compound NCCO.CCCCCCCCCCCCOS(O)(=O)=O QVBODZPPYSSMEL-UHFFFAOYSA-N 0.000 claims description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 2
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 229940094506 lauryl betaine Drugs 0.000 claims description 2
- 229940069822 monoethanolamine lauryl sulfate Drugs 0.000 claims description 2
- KKXWPVVBVWBKBL-UHFFFAOYSA-N n,n-diethylethanamine;dodecyl hydrogen sulfate Chemical compound CC[NH+](CC)CC.CCCCCCCCCCCCOS([O-])(=O)=O KKXWPVVBVWBKBL-UHFFFAOYSA-N 0.000 claims description 2
- DVEKCXOJTLDBFE-UHFFFAOYSA-N n-dodecyl-n,n-dimethylglycinate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 claims description 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 2
- 229920001451 polypropylene glycol Polymers 0.000 claims description 2
- 229960003975 potassium Drugs 0.000 claims description 2
- ONQDVAFWWYYXHM-UHFFFAOYSA-M potassium lauryl sulfate Chemical compound [K+].CCCCCCCCCCCCOS([O-])(=O)=O ONQDVAFWWYYXHM-UHFFFAOYSA-M 0.000 claims description 2
- 229940116985 potassium lauryl sulfate Drugs 0.000 claims description 2
- XNGJZISLHDSMTR-UHFFFAOYSA-M potassium;dodecanoyl sulfate Chemical compound [K+].CCCCCCCCCCCC(=O)OS([O-])(=O)=O XNGJZISLHDSMTR-UHFFFAOYSA-M 0.000 claims description 2
- 229940023565 ppg-10 cetyl ether Drugs 0.000 claims description 2
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- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 7
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims 2
- TYTGWHZODQKWEF-UHFFFAOYSA-N 1-o-dodecyl 4-o-sulfo butanedioate Chemical compound CCCCCCCCCCCCOC(=O)CCC(=O)OS(O)(=O)=O TYTGWHZODQKWEF-UHFFFAOYSA-N 0.000 claims 1
- QBMNPDGCXLRKEA-UHFFFAOYSA-N carboxy 2-aminoacetate Chemical compound NCC(=O)OC(O)=O QBMNPDGCXLRKEA-UHFFFAOYSA-N 0.000 claims 1
- 229940079886 disodium lauryl sulfosuccinate Drugs 0.000 claims 1
- CPDFYYNTIMGJLF-UHFFFAOYSA-L disodium;2-dodecylbutanedioate Chemical compound [Na+].[Na+].CCCCCCCCCCCCC(C([O-])=O)CC([O-])=O CPDFYYNTIMGJLF-UHFFFAOYSA-L 0.000 claims 1
- LTVJJSFLSYSCEF-UHFFFAOYSA-L disodium;4-dodecoxy-4-oxo-3-sulfonatobutanoate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOC(=O)C(S([O-])(=O)=O)CC([O-])=O LTVJJSFLSYSCEF-UHFFFAOYSA-L 0.000 claims 1
- 229940071180 lauryl sulfosuccinate Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 13
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- 244000269722 Thea sinensis Species 0.000 description 10
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 9
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- 230000008901 benefit Effects 0.000 description 8
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- 239000004615 ingredient Substances 0.000 description 8
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- 125000002252 acyl group Chemical group 0.000 description 7
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- 235000006468 Thea sinensis Nutrition 0.000 description 4
- LMETVDMCIJNNKH-UHFFFAOYSA-N [(3,7-Dimethyl-6-octenyl)oxy]acetaldehyde Chemical compound CC(C)=CCCC(C)CCOCC=O LMETVDMCIJNNKH-UHFFFAOYSA-N 0.000 description 4
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- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 4
- 239000002738 chelating agent Substances 0.000 description 4
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000003906 humectant Substances 0.000 description 4
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 4
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- A—HUMAN NECESSITIES
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Abstract
本发明涉及一种双相化妆品组合物,其中两个分开的相作为乳液相和清澈水相存在。本发明还涉及一种施用包含化妆品活性成分的双相化妆品组合物的方法以及该双相化妆品组合物作为化妆品活性成分的输送系统的用途。
Description
发明领域
本发明涉及一种双相化妆品组合物,其中两个分开的相作为乳液相和清澈水相存在。本发明还涉及一种施用包含化妆品活性成分的双相化妆品组合物的方法以及该双相化妆品组合物作为化妆品活性成分的输送系统的用途。
发明背景
常规双相化妆品组合物是已知的,即包含两个不混溶相,其静止时彼此不同且在摇动该组合物时能够形成宏观均匀混合物,此时两相之一通常以细液滴或微滴形式分散于另一相中。这些组合物通常以两个分开相包含水相和油相。
油的施用尽管带给皮肤明显的柔软度、有光泽的外观和保护性效果,但由于诸如不爽的油腻感和厚重感的问题而作为化妆品并不完全令人满意。
因此,需要一种可以同时对皮肤输送水基和油基成分而获得非常柔软和新鲜感觉的双相化妆品组合物,其不仅可以提供清洁效果,而且可以提供保湿和滑爽的护肤效果。此外,有利的是该组合物额外具有独特迷人的外观以吸引消费者注意。该组合物应以使得在油性组分量降低下保留各自益处的方式输送各相的组分。进一步需要含有降低量的可能对皮肤具有意想不到的有害影响并且具有生物积累问题的表面活性剂的该化妆品组合物。
发明概述
本发明的一个目的在于提供一种双相化妆品组合物,其中两个分开的相作为乳液相和清澈水相存在。当摇动该组合物时,两相混合形成暂时均匀乳液,此时将其施用于皮肤而获得非常柔软和新鲜感觉。两相的清晰分离面将在8小时内,优选6小时内的沉降时间段之后恢复。
本发明的目的可以通过一种包含式R-O-(R’)nH的脂肪醇聚氧化烯醚的双相化妆品组合物实现,其中R为饱和或不饱和的线性或支化C8-C22烃链,R’选自氧亚乙基和氧亚丙基及其组合并且n为2-30,优选该脂肪醇聚氧化烯醚基于该双相化妆品组合物的总重量以0.001-1.0重量%的量存在。
本发明的目的可以进一步通过一种包含式R-O-(R’)nH的脂肪醇聚氧化烯醚和至少一种油组分的双相化妆品组合物实现,其中R为饱和或不饱和的线性或支化C8-C22烃链或者饱和或不饱和的线性或支化C8-C22烃链的混合物,R’选自氧亚乙基和氧亚丙基及其组合并且n为2-30,其中该油组分包含烃和烃衍生物、甘油酯、醚、酯、碳酸酯、脂肪醇、脂肪酸、脂肪酸酯、脂肪醇醚、植物油、动物油、硅油、矿物油(石蜡油)及其组合,优选该脂肪醇聚氧化烯醚基于该双相化妆品组合物的总重量以0.001-1.0重量%的量存在。
本发明的目的可以进一步通过一种包含式R-O-(R’)nH的脂肪醇聚氧化烯醚和至少一种具有6-22个碳原子的脂肪醇的双相化妆品组合物实现,其中R为饱和或不饱和的线性或支化C8-C22烃链或者饱和或不饱和的线性或支化C8-C22烃链的混合物,R’选自氧亚乙基和氧亚丙基及其组合并且n为2-30,优选该脂肪醇聚氧化烯醚基于该双相化妆品组合物的总重量以0.001-1.0重量%的量存在。
本发明的目的可以进一步通过一种包含式R-O-(R’)nH的脂肪醇聚氧化烯醚和具有6-22个碳原子的脂肪醇的双相化妆品组合物实现,其中R为饱和或不饱和的线性或支化C8-C22烃链或者饱和或不饱和的线性或支化C8-C22烃链的混合物,R’选自氧亚乙基和氧亚丙基及其组合并且n为2-30,优选该脂肪醇聚氧化烯醚基于该双相化妆品组合物的总重量以0.001-1.0重量%的量存在并且该脂肪醇聚氧化烯醚与脂肪醇的重量比为1:10-10:1。
本发明的目的可以进一步通过一种包含式R-O-(R’)nH的脂肪醇聚氧化烯醚以及至少一种选自阴离子表面活性剂和两性表面活性剂的表面活性剂的双相化妆品组合物实现,其中R为饱和或不饱和的线性或支化C8-C22烃链或者饱和或不饱和的线性或支化C8-C22烃链的混合物,R’选自氧亚乙基和氧亚丙基及其组合并且n为2-30,优选该脂肪醇聚氧化烯醚基于该双相化妆品组合物的总重量以0.001-1.0重量%的量存在并且该阴离子表面活性剂或两性表面活性剂基于该双相化妆品组合物的总重量以0.001-5重量%的量存在。
本发明的目的可以进一步通过一种包含式R-O-(R’)nH的脂肪醇聚氧化烯醚,具有6-22个碳原子的脂肪醇以及至少一种选自阴离子表面活性剂和两性表面活性剂的表面活性剂的双相化妆品组合物实现,其中R为饱和或不饱和的线性或支化C8-C22烃链或者饱和或不饱和的线性或支化C8-C22烃链的混合物,R’选自氧亚乙基和氧亚丙基及其组合并且n为2-30,优选该脂肪醇聚氧化烯醚基于该双相化妆品组合物的总重量以0.001-1.0重量%的量存在,该脂肪醇聚氧化烯醚与脂肪醇的重量比为1:10-10:1并且该阴离子表面活性剂或两性表面活性剂基于该双相化妆品组合物的总重量以0.001-5重量%的量存在。
因此,本发明在第一方面提供了一种双相化妆品组合物,包含式R-O-(R’)nH的脂肪醇聚氧化烯醚,其中R为饱和或不饱和的线性或支化C8-C22烃链或者饱和或不饱和的线性或支化C8-C22烃链的混合物,R’选自氧亚乙基和氧亚丙基及其组合并且n为2-30,其中两个分开的相作为乳液相和清澈水相存在并且优选该脂肪醇聚氧化烯醚基于该双相化妆品组合物的总重量以0.001-1.0重量%的量存在。
在一些实施方案中,本发明双相化妆品组合物包含脂肪醇聚氧化烯醚和具有6-22个碳原子的脂肪醇,其中优选该脂肪醇聚氧化烯醚基于该双相化妆品组合物的总重量以0.001-1.0重量%的量存在并且该脂肪醇聚氧化烯醚与脂肪醇的重量比为1:10-10:1。
在其他实施方案中,本发明双相化妆品组合物包含脂肪醇聚氧化烯醚以及至少一种选自阴离子表面活性剂和两性表面活性剂的表面活性剂,其中优选该脂肪醇聚氧化烯醚基于该双相化妆品组合物的总重量以0.001-1.0重量%的量存在并且该阴离子表面活性剂或两性表面活性剂基于该双相化妆品组合物的总重量以0.001-5重量%的量存在。
在其他优选实施方案中,本发明双相化妆品组合物包含脂肪醇聚氧化烯醚,具有6-22个碳原子的脂肪醇以及至少一种选自阴离子表面活性剂和两性表面活性剂的表面活性剂,其中优选该脂肪醇聚氧化烯醚基于该双相化妆品组合物的总重量以0.001-1.0重量%的量存在,该脂肪醇聚氧化烯醚与脂肪醇的重量比为1:10-10:1并且该阴离子表面活性剂或两性表面活性剂基于该双相化妆品组合物的总重量以0.001-5重量%的量存在。
本发明在第二方面提供了一种制备本发明双相化妆品组合物的方法,包括混合该双相化妆品组合物的各组分。
本发明在第三方面提供了包含稳定存在于该组合物中的化妆品活性成分的双相化妆品组合物。
本发明在第四方面提供了本发明双相化妆品组合物作为化妆品活性成分的输送系统的用途。
本发明在第五方面提供了一种施用本发明包含化妆品活性成分的双相化妆品组合物的方法,包括振摇该组合物以形成宏观均匀混合物并将该混合物施用于皮肤。
已经发现本发明双相化妆品组合物包含两个分开的相作为乳液相和基本清澈或清澈水相,其中在静止时该乳液相漂浮在该水相上并且形成两相的清晰分离面。当振摇本发明双相化妆品组合物时,两相混合形成暂时均匀乳液并且两相的清晰分离面将在8小时内,优选6小时内的沉降时间段之后恢复。本发明双相化妆品组合物可以同时对皮肤输送水基和油基成分而获得非常柔软和新鲜感觉。本发明双相化妆品组合物可以以使得在油性组分量降低下保留各自益处的方式输送各相的组分。本发明双相化妆品组合物含有降低量的可能对皮肤具有意想不到的有害影响并且具有生物积累问题的表面活性剂。
附图说明
图1显示发明例1的双相化妆品组合物在静止时的照片,该组合物包含乳液相和清澈水相,其中在静止时该乳液相漂浮在该清澈水相上并且形成两相的清晰分离面。
图2显示对比例1的组合物在静止时的照片,其中发生水-油相分离并且水相出现絮凝物。
图3显示对比例2的组合物在静止时的照片,其中水和油分离,没有形成包含乳液相和清澈水相的双相化妆品组合物。
发明详述
除非另有定义,否则本文所用所有技术和科学术语具有本发明所述技术领域的普通技术人员所通常理解的相同含义。
当用于限定术语时,表述“一个”、“一种”、“该”包括该术语的复数和单数形式二者。
除非另有规定,所有百分数、份数和比率按整个组合物的重量计。所有该类重量在它们涉及所列组分时基于特定成分水平并且因此不包括可能包括在市售材料中的载体或副产物,除非另有规定。
本发明在第一方面提供了一种包含式R-O-(R’)nH的脂肪醇聚氧化烯醚的双相化妆品组合物,其中R为饱和或不饱和的线性或支化C8-C22烃链或者饱和或不饱和的线性或支化C8-C22烃链的混合物,R’选自氧亚乙基和氧亚丙基及其组合,优选氧亚乙基并且n为2-30,其中两个分开的相作为乳液相和清澈水相存在并且优选该脂肪醇聚氧化烯醚基于该双相化妆品组合物的总重量以0.001-1.0重量%的量存在。
脂肪醇聚氧化烯醚
在本发明上下文中,该脂肪醇聚氧化烯醚具有式R-O-(R’)nH,其中R为饱和或不饱和的线性或支化C8-C22烃链或者饱和或不饱和的线性或支化C8-C22烃链的混合物,优选饱和或不饱和的线性或支化C10-C20烃链或者饱和或不饱和的线性或支化C10-C20烃链的混合物,更优选饱和或不饱和的线性或支化C12-C18烃链或者饱和或不饱和的线性或支化C12-C18烃链的混合物,R’选自氧亚乙基和氧亚丙基及其组合,优选氧亚乙基并且n为2-30,优选10-30,更优选15-30。
脂肪醇聚氧化烯醚的非限制性实例包括脂肪醇聚氧乙烯醚,后者选自鲸蜡硬脂醇聚醚系列,如鲸蜡硬脂醇聚醚-2至鲸蜡硬脂醇聚醚-30,优选鲸蜡硬脂醇聚醚-10、鲸蜡硬脂醇聚醚-20或鲸蜡硬脂醇聚醚-30,更优选鲸蜡硬脂醇聚醚-20或鲸蜡硬脂醇聚醚-30;鲸蜡醇聚醚系列,如鲸蜡醇聚醚-2至鲸蜡醇聚醚-30,优选鲸蜡醇聚醚-10、鲸蜡醇聚醚-20或鲸蜡醇聚醚-30,更优选鲸蜡醇聚醚-20或鲸蜡醇聚醚-30;硬脂醇聚醚系列,如硬脂醇聚醚-2至硬脂醇聚醚-30,优选硬脂醇聚醚-10、硬脂醇聚醚-20或硬脂醇聚醚-30,更优选硬脂醇聚醚-20或硬脂醇聚醚-30;以及月桂醇聚醚系列,如月桂醇聚醚-2至月桂醇聚醚-30,优选月桂醇聚醚-10、月桂醇聚醚-20或月桂醇聚醚-30,更优选月桂醇聚醚-20或月桂醇聚醚-30;脂肪醇聚氧丙烯醚,后者选自PPG-10鲸蜡基醚、PPG-28鲸蜡基醚、PPG-30鲸蜡基醚和PPG-11硬脂基醚;以及还有脂肪醇聚氧乙烯-聚氧丙烯醚,后者选自PPG-4鲸蜡硬脂醇聚醚-12、PPG-4鲸蜡硬脂醇聚醚-20、PPG-10鲸蜡硬脂醇聚醚-20、PPG-4鲸蜡醇聚醚-1、PPG-4鲸蜡醇聚醚-5、PPG-4鲸蜡醇聚醚-10、PPG-4癸醇聚醚-4、PPG-5鲸蜡醇聚醚-20、PPG-8鲸蜡醇聚醚-1、PPG-8鲸蜡醇聚醚-2、PPG-8鲸蜡醇聚醚-5、PPG-8鲸蜡醇聚醚-10、PPG-8鲸蜡醇聚醚-20和PPG-9硬脂醇聚醚-3。
在优选实施方案中,该脂肪醇聚氧化烯醚包括脂肪醇聚氧乙烯醚,后者选自鲸蜡硬脂醇聚醚系列,如鲸蜡硬脂醇聚醚-2至鲸蜡硬脂醇聚醚-30,优选鲸蜡硬脂醇聚醚-10、鲸蜡硬脂醇聚醚-20或鲸蜡硬脂醇聚醚-30,更优选鲸蜡硬脂醇聚醚-20或鲸蜡硬脂醇聚醚-30;鲸蜡醇聚醚系列,如鲸蜡醇聚醚-2至鲸蜡醇聚醚-30,优选鲸蜡醇聚醚-10、鲸蜡醇聚醚-20或鲸蜡醇聚醚-30,更优选鲸蜡醇聚醚-20或鲸蜡醇聚醚-30;硬脂醇聚醚系列,如硬脂醇聚醚-2至硬脂醇聚醚-30,优选硬脂醇聚醚-10、硬脂醇聚醚-20或硬脂醇聚醚-30,更优选硬脂醇聚醚-20或硬脂醇聚醚-30;以及月桂醇聚醚系列,如月桂醇聚醚-2至月桂醇聚醚-30,优选月桂醇聚醚-10、月桂醇聚醚-20或月桂醇聚醚-30,更优选月桂醇聚醚-20或月桂醇聚醚-30。
在更优选的实施方案中,该脂肪醇聚氧化烯醚包括脂肪醇聚氧乙烯醚,后者选自鲸蜡硬脂醇聚醚系列,如鲸蜡硬脂醇聚醚-2至鲸蜡硬脂醇聚醚-30,优选鲸蜡硬脂醇聚醚-10、鲸蜡硬脂醇聚醚-20或鲸蜡硬脂醇聚醚-30,更优选鲸蜡硬脂醇聚醚-20或鲸蜡硬脂醇聚醚-30(例如B2(购自BASF)和/>B3(购自BASF))。
该脂肪醇聚氧化烯醚基于该双相化妆品组合物的总重量可以以0.001-1.0重量%,例如0.005-0.2重量%,优选0.01-0.15重量%,更优选0.03-0.1重量%的量存在。
油组分
本发明双相化妆品组合物在乳液相中包含油组分。油组分可以包含烃和烃衍生物、甘油酯、醚、酯、碳酸酯、脂肪醇、脂肪酸、脂肪酸酯、脂肪醇醚、植物油、动物油、硅油、矿物油(石蜡油)及其组合。
本发明双相化妆品组合物的油组分有利地选自卵磷脂和脂肪酸甘油三酯,即链长为8-24个,尤其是12-18个碳原子的饱和和/或不饱和的支化和/或未支化链烷羧酸的三甘油酯。脂肪酸甘油三酯例如可以有利地选自合成、半合成和天然油,如橄榄油、葵花油、大豆油、花生油、菜籽油、杏仁油、棕榈油、椰子油、蓖麻油、小麦胚芽油、葡萄籽油、红花油、月见草油、澳洲坚果油等。其他极性油组分可以选自链长为3-30个碳原子的饱和和/或不饱和的支化和/或未支化链烷羧酸与链长为3-30个碳原子的饱和和/或不饱和的支化和/或未支化醇的酯以及还选自芳族羧酸与链长为3-30个碳原子的饱和和/或不饱和的支化和/或未支化醇的酯。该类酯油此时可以有利地选自肉豆蔻酸异丙酯、棕榈酸异丙酯、硬脂酸异丙酯、油酸异丙酯、硬脂酸正丁酯、月桂酸正己酯、油酸正癸酯、硬脂酸异辛酯、硬脂酸异壬酯、异壬酸异壬酯、棕榈酸2-乙基己基酯、月桂酸2乙基己基酯、硬脂酸2-己基癸基酯、棕榈酸2-辛基十二烷基酯、油醇油酸酯、油醇芥酸酯、瓢儿菜醇油酸酯、瓢儿菜醇芥酸酯、碳酸二辛酯(例如CC(购自BASF))和椰油酸甘油酯类(/>331)、丁二醇二辛酸酯/二癸酸酯和丁二醇己二酸酯,以及还有该类酯的合成、半合成和天然混合物,如霍霍巴油。
此外,一种或多种油组分可以有利地选自支化和未支化烃,如C10-C18链烷烃,优选十一烷或十三烷或其组合(例如Ultimate(购自BASF)),二烷基醚,如二辛基醚(例如/>OE(购自BASF))。
优选一种或多种油组分可以有利地选自12-20个碳原子,优选14-18个碳原子的脂肪酸,例如月桂酸、棕榈酸、肉豆蔻酸或硬脂酸,优选棕榈酸(例如C16-98MY BD(购自Emery))。
该油组分还可以有利地具有一定含量的环状或线性硅油或者完全由该类油构成,但是优选使用额外含量的除一种或多种该硅油以外的其他油相组分。
低分子量聚硅氧烷或硅油通常由下列通式限定:
更高分子量聚硅氧烷或硅油通常由下列通式限定:
其中硅原子可以被相同或不同烷基和/或芳基取代,这些基团在这里笼统地由基团R1-R4表示。然而,不同基团的数目不一定限于至多4个。m在这里可以取值2-200 000。
根据本发明有利地使用的环状聚硅氧烷通常由下列通式限定:
其中硅原子可以被相同或不同烷基和/或芳基取代,这些基团在这里笼统地由基团R1-R4表示。然而,不同基团的数目不一定限于至多4个。n在这里可以取值3/2-20。n的分数值考虑的是在该环中可以存在奇数个甲硅烷基。
有利地将苯基聚三甲基硅氧烷选择作为硅油。在本发明上下文中也有利地使用其他硅油,例如二甲聚硅氧烷、六甲基环三硅氧烷、苯基聚二甲基硅氧烷、环二甲聚硅氧烷(例如十甲基环五硅氧烷、环五硅氧烷环六硅氧烷)、六甲基环三硅氧烷、聚二甲基硅氧烷、聚(甲基苯基硅氧烷)、鲸蜡基二甲聚硅氧烷、山氧基二甲聚硅氧烷。环二甲聚硅氧烷和异壬酸异十三烷基酯的混合物以及还有环二甲聚硅氧烷和异硬脂酸2-乙基己基酯的那些也是有利的。
然而,还有利的是选择与衍生其有机侧链的上述化合物具有类似组成的硅油,例如聚乙氧基化和/或聚丙氧基化的。这些例如包括聚硅氧烷多烷基-聚醚共聚物,如鲸蜡基二甲聚硅氧烷共聚多元醇。
合适的化妆品相容性油组分描述于Karl-Heinz Schrader,Grundlagen undRezepturen der Kosmetika[化妆品基础和配制剂],第2版,Verlag Hüthig,Heidelberg,第319-355页中,其整体在本文作为参考。
在优选实施方案中,油组分选自链长为3-30个碳原子的饱和和/或不饱和的支化和/或未支化链烷羧酸与链长为3-30个碳原子的饱和和/或不饱和的支化和/或未支化醇的酯以及还有芳族羧酸与链长为3-30个碳原子的饱和和/或不饱和的支化和/或未支化醇的酯,优选肉豆蔻酸异丙酯、棕榈酸异丙酯、硬脂酸异丙酯、油酸异丙酯、硬脂酸正丁酯、月桂酸正己酯、油酸正癸酯、硬脂酸异辛酯、硬脂酸异壬酯、异壬酸异壬酯、棕榈酸2-乙基己基酯、月桂酸2乙基己基酯、硬脂酸2-己基癸基酯、棕榈酸2-辛基十二烷基酯、油醇油酸酯、油醇芥酸酯、瓢儿菜醇油酸酯、瓢儿菜醇芥酸酯、碳酸二辛酯(例如CC(购自BASF))和椰油酸甘油酯类(/>331)、丁二醇二辛酸酯/二癸酸酯和丁二醇己二酸酯,以及还有该类酯的合成、半合成和天然混合物,如霍霍巴油;以及支化和未支化烃,如C10-C18链烷烃,优选十一烷或十三烷或其组合(例如/>Ultimate(购自BASF)),二烷基醚,如二辛基醚(例如/>OE(购自BASF)),12-20个碳原子,优选14-18个碳原子的脂肪酸,例如月桂酸、棕榈酸、肉豆蔻酸或硬脂酸,优选棕榈酸(例如/>C16-98MY BD(购自Emery))。
该油组分可以基于该双相化妆品组合物的总重量以1-20重量%,优选2-18重量%,更优选3-16重量%,进一步更优选3-12重量%的量存在。
在更优选的实施方案中,本发明双相化妆品组合物包含具有6-22个碳原子的脂肪醇。
适合用于该双相化妆品组合物中的脂肪醇在这里选自具有6-22个,优选10-20个,更优选12-18个碳原子的饱和或不饱和的支化或未支化醇如格尔伯特醇,包括2-丁基辛醇(例如作为12(Condea)市购)、2-己基癸醇(例如作为/>16(Condea)市购)、2-丁基辛醇和2-己基癸醇的混合物(例如作为/>14(Condea)市购)、鲸蜡醇、硬脂醇、鲸蜡硬脂醇(例如/>O(购自BASF))、油醇、辛基十二烷醇(例如/>G(购自BASF))等,优选鲸蜡醇、硬脂醇、鲸蜡硬脂醇(例如/>O(购自BASF))、油醇、辛基十二烷醇(例如G(购自BASF)),更优选鲸蜡硬脂醇。
该脂肪醇聚氧化烯醚与脂肪醇的重量比为1:10-10:1,优选1:8-5:1,更优选1:5-1:1。
阴离子表面活性剂
在其他实施方案中,本发明双相化妆品组合物包含该脂肪醇聚氧化烯醚以及至少一种选自阴离子表面活性剂和两性表面活性剂的表面活性剂。
在其他优选实施方案中,本发明双相化妆品组合物包含脂肪醇聚氧化烯醚、具有6-22个碳原子的脂肪醇以及至少一种选自阴离子表面活性剂和两性表面活性剂的表面活性剂,其中优选该脂肪醇聚氧化烯醚基于该双相化妆品组合物的总重量以0.001-1.0重量%的量存在。
本发明组合物可以包含常用于化妆品组合物中的任何阴离子表面活性剂。优选的阴离子表面活性剂包括硫酸盐阴离子表面活性剂、氨基酸阴离子表面活性剂、磺基琥珀酸盐阴离子表面活性剂和磺化脂肪酸和/或二盐阴离子表面活性剂。
合适硫酸盐阴离子表面活性剂的非限制性实例包括月桂基硫酸铵、月桂醇聚醚硫酸铵、三乙胺月桂基硫酸盐、三乙胺月桂醇聚醚硫酸盐、单乙醇胺月桂基硫酸盐、单乙醇胺月桂醇聚醚硫酸盐、二乙醇胺月桂基硫酸盐、二乙醇胺月桂醇聚醚硫酸盐、三乙醇胺月桂基硫酸盐、三乙醇胺月桂醇聚醚硫酸盐、甘油单月桂酸酯硫酸钠、月桂基硫酸钠、月桂醇聚醚硫酸钠、月桂基硫酸钾、月桂醇聚醚硫酸钾、椰油酰硫酸铵、月桂酰硫酸铵、椰油酰硫酸钠、月桂酰硫酸钠、椰油酰硫酸钾、月桂酰硫酸钾、鲸蜡硬脂基硫酸铵、鲸蜡硬脂基硫酸钠、鲸蜡硬脂基硫酸钾及其组合,优选月桂醇聚醚硫酸铵、月桂醇聚醚硫酸钠、月桂醇聚醚硫酸钾、鲸蜡硬脂基硫酸铵、鲸蜡硬脂基硫酸钠和鲸蜡硬脂基硫酸钾,更优选月桂醇聚醚硫酸钠和鲸蜡硬脂基硫酸钠(例如E Granules(购自BASF)、/>NSO UP(购自BASF)、OC-P(购自BASF)、/>OC-N(购自BASF)、/>N 703(购自BASF)、N 701(购自BASF)、/>N70(购自BASF)和/>N 28S(购自BASF))。
合适氨基酸阴离子表面活性剂的非限制性实例包括酰基谷氨酸盐、酰基牛磺酸盐、酰基甘氨酸盐、酰基丙氨酸盐、酰基肌氨酸盐和酰基天冬氨酸盐。盐的实例包括碱金属盐如钠盐(Na)和钾盐(K);碱土金属盐如钙(Ca)和镁(Mg)盐;三乙醇胺盐(TEA);铵盐;等等。例如更优选钾盐、钠盐、三乙醇胺盐和铵盐,尤其是钠盐。
优选酰基谷氨酸盐包括椰油酰谷氨酸盐、月桂酰谷氨酸盐、肉豆蔻酰谷氨酸盐、棕榈酰谷氨酸盐、硬脂酰谷氨酸盐、氢化牛脂酰谷氨酸盐、橄榄油酰基谷氨酸盐和辛酰谷氨酸盐,例如椰油酰谷氨酸钠、月桂酰谷氨酸钠、肉豆蔻酰谷氨酸钠、棕榈酰谷氨酸钠、硬脂酰谷氨酸钠、椰油酰谷氨酸二钠、硬脂酰谷氨酸二钠、椰油酰谷氨酸钾、月桂酰谷氨酸钾和肉豆蔻酰谷氨酸钾,更优选椰油酰谷氨酸钠和硬脂酰谷氨酸钠(例如Amino SCG-L(购自BASF)、/>Amino SLG-P(INCI:月桂酰谷氨酸钠,购自BASF)、/>ACGLC(购自BASF)、/>ACG HC(购自BASF)、/>ACG 35(购自BASF)、ACG 50(购自BASF)、/>SG(购自BASF)、/>KCG(购自Clariant)和/>KCG(购自Clariant))。
优选酰基牛磺酸盐包括椰油酰牛磺酸盐、椰油酰甲基牛磺酸盐、月桂酸牛磺酸盐、月桂酰甲基牛磺酸盐、硬脂酰甲基牛磺酸盐、肉豆蔻酰甲基牛磺酸盐、棕榈酰甲基牛磺酸盐、油酰甲基牛磺酸盐、己酰甲基牛磺酸盐和月桂酰甲基β-丙氨酸牛磺酸盐。例如,特别优选椰油酰牛磺酸盐、椰油酰甲基牛磺酸盐、月桂酸牛磺酸盐、月桂酰牛磺酸盐和月桂酰甲基牛磺酸盐。例如进一步特别优选椰油酰牛磺酸钠、甲基椰油酰牛磺酸钾、甲基椰油酰牛磺酸钠、甲基椰油酰牛磺酸镁、椰油酰甲基牛磺酸牛磺酸钠、牛磺酸钾月桂酸盐、月桂酰牛磺酸钠和甲基月桂酰牛磺酸钠,更优选椰油酰甲基牛磺酸牛磺酸钠(例如NEOSCOAP CDT-30(CR)、NEOSCOAPCDT-30-SF(CR)、NEOSCOAP CDT-30-SF、NEOSCOAP CN-30(CR)和NEOSCOAPCN-30-SF(购自Toho Chemical Industry))。
优选酰基甘氨酸盐包括椰油酰甘氨酸盐、棕榈酰甘氨酸盐、辛酰甘氨酸盐和十一碳烯酰甘氨酸盐。例如甚至更优选椰油酰甘氨酸盐。例如特别优选椰油酰甘氨酸钾(Amino KG-L和/>Amino KG-P,购自BASF)和椰油酰甘氨酸钠,更优选椰油酰甘氨酸钠。
优选酰基丙氨酸盐包括椰油酰丙氨酸盐、椰油酰甲基丙氨酸盐、月桂酰甲基丙氨酸盐和肉豆蔻酰甲基丙氨酸盐。例如甚至更优选椰油酰丙氨酸盐、椰油酰甲基丙氨酸盐和月桂酰甲基丙氨酸盐。例如特别优选椰油酰丙氨酸钠、TEA椰油酰丙氨酸盐、椰油酰甲基丙氨酸钠、月桂酰甲基丙氨酸钠和TEA月桂酰甲基丙氨酸盐,更优选椰油酰丙氨酸钠。
优选酰基肌氨酸盐包括椰油酰肌氨酸盐、月桂酰肌氨酸盐、肉豆蔻酰肌氨酸盐、棕榈酰肌氨酸盐和油酰肌氨酸盐。例如特别优选椰油酰肌氨酸盐和月桂酰肌氨酸盐。例如进一步特别优选椰油酰肌氨酸钾、椰油酰肌氨酸钠、TEA椰油酰肌氨酸盐、月桂酰肌氨酸钾、月桂酰肌氨酸钠和TEA月桂酰肌氨酸盐,更优选椰油酰肌氨酸钠。
优选酰基天冬氨酸盐包括棕榈酰天冬氨酸盐、肉豆蔻基天冬氨酸盐、月桂基天冬氨酸盐和月桂酰天冬氨酸盐。例如甚至更优选月桂基天冬氨酸盐和月桂酰天冬氨酸盐。特别优选月桂基天冬氨酸钾、月桂基天冬氨酸钠、TEA月桂基天冬氨酸盐和月桂酰天冬氨酸钠,更优选月桂酰天冬氨酸钠。
合适磺基琥珀酸盐阴离子表面活性剂的非限制性实例包括磺基琥珀酸二辛酯钠、月桂醇聚醚磺基琥珀酸酯二钠、月桂醇磺基琥珀酸酯二钠、鲸蜡硬脂醇磺基琥珀酸酯二钠、磺基琥珀酸亚十一烷基酰胺基MEA二钠和PEG-5月桂醇柠檬酸酯磺基琥珀酸酯二钠,优选月桂醇磺基琥珀酸酯二钠和鲸蜡硬脂醇磺基琥珀酸酯二钠,更优选鲸蜡硬脂醇磺基琥珀酸酯二钠(例如Prisma(购自BASF))。
合适磺化脂肪酸和/或二盐阴离子表面活性剂的非限制性实例是式(1)化合物:
R0CH(SO3M1)COOM2(1)
其中R0为饱和或不饱和的线性或支化C8-C16烃链以及M1和M2独立地为H、Li、Na、K、Ca/2、Mg/2、铵或链烷醇胺。
优选R0为饱和的线性C8-C16烃链,优选饱和的线性C10-C14烃链。
更优选M1和M2为Na。
最优选该磺化脂肪酸和/或二盐阴离子表面活性剂为2-磺基月桂酸二钠(例如SFA(购自BASF))。
阴离子表面活性剂基于该双相化妆品组合物的总重量可以以0.001-5重量%,优选0.005-1重量%,进一步优选0.006-0.5重量%,更优选0.01-0.1重量%,最优选0.04-0.1重量%的量存在。
两性表面活性剂
合适两性表面活性剂的非限制性实例包括酰基两性基乙酸钠、酰基两性基二丙酸二钠、烷基两性基二乙酸二钠、酰基两性基羟丙基磺酸钠、酰基两性基二乙酸二钠、酰基两性基丙酸钠和N-椰油脂肪酸酰胺基乙基N-羟乙基甘氨酸钠盐。
其他有利的两性表面活性剂为N-烷基氨基酸,例如氨丙基烷基谷氨酰胺、烷基氨基丙酸、烷基酰亚胺基二丙酸钠和月桂酰两性基羧基甘氨酸盐。
合适的两性表面活性剂例如还有烷基甜菜碱、烷基酰胺基丙基甜菜碱、烷基磺基甜菜碱、烷基甘氨酸盐、烷基羧基甘氨酸盐、烷基两性基乙酸盐或-丙酸盐、烷基两性基二乙酸盐或-二丙酸盐,优选椰油基二甲基磺基丙基甜菜碱、月桂基甜菜碱、椰油酰胺基丙基甜菜碱或椰油酰两性基丙酸钠,更优选椰油酰胺基丙基甜菜碱(例如PK 45(购自BASF)、/>KE-AS(购自BASF)、/>K/I5(购自BASF)、/>DC-AS、ML、/>Betain P 50C(购自Evonik)、/>Betain F 50(购自Evonik)和CAB 818(购自Clariant))。
两性表面活性剂基于该双相化妆品组合物的总重量可以以0.001-5重量%,优选0.005-1重量%,进一步优选0.006-0.5重量%,更优选0.01-0.1重量%,最优选0.04-0.1重量%的量存在。
在其他优选实施方案中,本发明双相化妆品组合物进一步包含下列其他成分。
保湿剂
适合本发明双相化妆品组合物的保湿剂是低碳原子数的乙氧基化或非乙氧基化单醇、二醇或多元醇或其醚(例如乙醇、异丙醇、1,2-二丙二醇、丙二醇、甘油、乙二醇、乙二醇单乙基醚、乙二醇单丁基醚(乙二醇丁醚)、丙二醇单甲基醚、丙二醇单乙基醚、丙二醇单丁基醚、二甘醇单甲基醚、二甘醇单乙基醚、二甘醇单丁基醚和类似产品)。对该目的考虑的多元醇优选具有2-15个碳原子和至少两个羟基。多元醇还可以含有其他官能基团,尤其是氨基,和/或可以用氮改性。典型实例如下:甘油,亚烷基二醇,例如乙二醇、二甘醇、丙二醇、丁二醇、己二醇以及还有平均分子量为100-1000道尔顿的聚乙二醇(例如E 400(购自BASF));固有缩合度为1.5-10的工业低聚甘油混合物,例如双甘油含量为40-50重量%的工业双甘油混合物;羟甲基化合物,尤其如三羟甲基乙烷、三羟甲基丙烷、三羟甲基丁烷、季戊四醇和二季戊四醇;低级烷基葡糖苷,尤其是在烷基中具有1-8个碳原子的那些,例如甲基和丁基葡糖苷;具有5-12个碳原子的糖醇,例如山梨糖醇或甘露糖醇;具有5-12个碳原子的糖类,例如葡萄糖或蔗糖;氨基糖类,例如葡糖胺;二醇胺类,如二乙醇胺或2-氨基-1,3-丙二醇。
该保湿剂基于该双相化妆品组合物的总重量可以以0.01-30重量%,优选0.1-15重量%,更优选1-5重量%的量存在。
螯合剂
适合本发明双相化妆品组合物的螯合剂可以选自乙二胺四乙酸(EDTA)、EDTA二钾、EDTA二钠、EDTA四钠、EDTA二铵、EDTA二钠钙、TEA-EDTA、EDTA三钾、EDTA三钠、羟乙基乙二胺三乙酸(HEDTA)、HEDTA三钠及其组合。在一个实施方案中,该螯合剂包含EDTA二钠(例如BD(购自BASF))。
螯合剂基于该双相化妆品组合物的总重量可以以0.001-1重量%,优选0.01-1.0重量%,更优选0.05-0.5重量%的量存在。
增稠剂
适合本发明双相化妆品组合物的增稠剂是多糖,优选黄原胶(例如XGN(购自BASF))、瓜尔豆胶、琼脂、藻酸盐或侵填体,纤维素衍生物,例如羟烷基纤维素,其中烷基为C1-C4烷基,特别是羟乙基纤维素,优选Herkules Incorporated的NatrosolTM商标,尤其优选NatrosolTM 250(CAS号9004-62-0),羧甲基纤维素或羟基羧甲基纤维素,淀粉,优选商标National 465、Purity W或淀粉B990,还有脂肪酸的相对高分子量聚乙二醇单-和二酯,脂肪醇,甘油单酯和脂肪酸。
合适的增稠剂还有聚丙烯酸酯,交联聚丙烯酸及其衍生物,如CD和TTA(购自BASF),/>(购自Lubrizol),/>(购自Lubrizol),EM(购自BASF),/>SP(购自BASF),/>GTC UP(购自BASF),/>98(购自Seppic),/>(购自Sigma),来自Rohm and Haas的/>品级,如22(具有硬脂基的丙烯酸酯/甲基丙烯酸共聚物乙氧基化物(20个氧化乙烯(EO)单元))和/>28(具有山/>基的丙烯酸酯/甲基丙烯酸共聚物乙氧基化物(25个EO单元))。
合适的增稠剂此外例如是气溶胶品级(亲水硅石),聚丙烯酰胺,聚乙烯醇和聚乙烯基吡咯烷酮,乙氧基化脂肪酸甘油酯,脂肪酸与多元醇如季戊四醇或三羟甲基丙烷的酯,具有窄同系物分布的脂肪醇乙氧基化物或烷基低聚葡糖苷,还有电解质如氯化钠和氯化铵。
增稠剂可以取决于其类型以本领域中的常规量存在。本领域熟练技术人员能够选择适合本发明的增稠剂和量。
在本发明上下文中,增稠剂基于该双相化妆品组合物的总重量可以以0.01-3重量%,优选0.02-2.0重量%,更优选0.04-1.5重量%的量存在。
防腐剂
本发明双相化妆品组合物可以有利地包含一种或多种防腐剂。
在本发明上下文中有利的防腐剂例如是甲醛供体(如DMDM乙内酰脲,例如以商品名(购自Lonza)购得),丁基氨基甲酸碘丙酯(例如/>(购自Lonza),/>LMB(购自Jan Dekker)),对羟基苯甲酸酯类(对羟基苯甲酸烷基酯,如对羟基苯甲酸甲酯、乙酯、丙酯和/或丁酯),脱氢乙酸(/>K 702(购自Schülke&Mayr),苯氧基乙醇,乙醇,苯甲酸或其组合。还有利地使用所谓的防腐助剂,例如辛氧基甘油、甘氨酸、大豆等。
还有利的是常用于化妆品中的防腐剂或防腐助剂,如二溴二氰基丁烷(2-溴-2-溴甲基戊二腈)、苯氧基乙醇、丁基氨基甲酸3-碘-2-丙炔酯、2-溴-2-硝基-1,3-丙二醇、咪唑烷基脲、5-氯-2-甲基-4-异噻唑啉-3-酮、2-氯乙酰胺、苄醇、水杨酸和水杨酸酯。
防腐剂基于该双相化妆品组合物的总重量可以以0.01-5重量%,优选0.1-2重量%,更优选0.2-1重量%的量存在。
芳香油
合适的话,本发明双相化妆品组合物可以包含芳香油。可以提及的芳香油例如为天然和合成香料的混合物。天然香料是来自花(百合花、薰衣草、玫瑰、茉莉、橙花、依兰花),茎和叶(天竺葵、广藿香、苦橙叶),果实(茴芹、芫荽、香菜、刺柏),果皮(香柠檬、柠檬、橙),根(肉豆蔻、白芷、芹菜、小豆蔻、闭鞘姜、鸢尾、菖蒲),木材(松木、檀香木、愈创木、雪松木、黄檀木),药草和禾草(龙蒿、柠檬草、鼠尾草、百里香),针和枝(云杉、冷杉、松树、矮山松),树脂和香脂(白松香、榄香脂、安息香、没药、乳香、胶质没药)的提取物。还合适的是动物原料,例如麝猫香和海狸香。典型的合成香料化合物是酯、醚、醛、酮、醇和烃类产物。酯类香料化合物例如是乙酸苄酯、异丁酸苯氧基乙基酯、乙酸4-叔丁基环己基酯、乙酸芳樟酯、原乙酸二甲基苄基酯、乙酸苯基乙基酯、苯甲酸芳樟酯、甲酸苄酯、苯基甘氨酸乙基甲基酯、环己基丙酸烯丙酯、丙酸苏合香酯和水杨酸苄酯。醚类例如包括苄基乙基醚,醛类例如包括具有8-18个碳原子的线性链烷醛、柠檬醛、香茅醛、香茅氧基乙醛、兔耳草醛、羟基香茅醛、铃兰醛和波洁红醛,酮类例如包括紫罗兰酮类、cc-异甲基紫罗兰酮和甲基柏木酮,醇类包括茴香脑、香茅醇、丁子香酚、异丁子香酚、香叶醇、芳樟醇、苯乙醇和萜品醇,并且烃类主要包括萜烯和香脂。然而,优选使用一起产生怡人香味的不同香料的混合物。最常用作芳香组分的较低挥发性精油也适合作为芳香油,例如鼠尾草油、春黄菊油、丁香油、蜂花油、薄荷油、肉桂叶油、菩提花油、杜松子油、香根油、乳香油、格蓬油、岩蔷薇油和杂熏衣草油。优选单独或者以混合物使用香柠檬油、二氢月桂烯醇、铃兰醛、新铃兰醛、香茅醇、苯乙醇、α-己基肉桂醛、香叶醇、苄基丙酮、兔耳草醛、芳樟醇、Forte、降龙涎香醚、吲哚、二氢茉莉酮酸甲酯、2-甲基-4-(2,2,3-三甲基-3-环戊烯-1-基)-2-丁烯-1-醇、柠檬油、橘油、橙油、戊基甘醇酸烯丙酯、cyclovertal、杂熏衣草油、香紫苏油、β-突厥酮、波旁香叶油、水杨酸环己酯、/>Coeur、iso/>NP、2,4-二羟基-3,6-二甲基苯甲酸甲酯、γ-甲基紫罗兰酮、苯乙酸、乙酸香叶酯、乙酸苄酯、玫瑰醚、romillat、依罗酯(irotyl)和2-叔丁基环己基乙基碳酸酯(floramat)。
芳香油可以以常规量存在于该双相化妆品组合物中。
不用说,本发明双相化妆品组合物应是化妆品上或皮肤学上可接受的,即它应含有生理上可接受的无毒介质并且应能施用于皮肤。对于本发明的目的而言,表述“化妆品上可接受的”是指外观、气味、感觉和/或味道令人愉快的组合物。
本发明在第二方面提供了一种制备本发明双相化妆品组合物的方法,包括混合该双相化妆品组合物的各组分。
本发明双相化妆品组合物通过将油相和水相的除脂肪醇聚氧化烯醚和表面活性剂(若使用的话)以外的预混组分以预定比例合并并随后加入脂肪醇聚氧化烯醚和表面活性剂(若使用的话)以形成双相组合物而制备。替换地,在搅动下一起或依次加入该双相化妆品组合物的各组分以有助于各成分分离进入合适相中。
本发明在第三方面提供了一种包含稳定存在于该组合物中的化妆品活性成分的双相化妆品组合物。
活性成分
已经发现可以将具有各种溶解度的活性成分均匀掺入本发明双相化妆品组合物中。
根据本发明,活性成分可以有利地选自NO合成酶抑制剂,特别是若本发明双相化妆品组合物要用于治疗和预防内因性和/或外显性老化的症状以及还用于治疗和预防紫外射线对皮肤的有害影响的话。优选的NO合成酶抑制剂是硝基精氨酸。
此外,活性成分有利地选自儿茶素类和儿茶素类的胆汁酸酯类以及来自具有儿茶素类或儿茶素类的胆汁酸酯类含量的植物或植物部分如植物家族山茶科(Theaceae),尤其是属种—茶树(Camellia sinensis)(绿茶)的叶子的含水或有机提取物。它们的典型成分(例如多酚类或儿茶素类、咖啡因、维生素、糖类、矿物、氨基酸、类脂)是特别有利的。
儿茶素类是一类被看作氢化黄酮类或花青素类的化合物并且为“儿茶素类”的衍生物(儿茶酚、3,3',4',5,7-黄烷五醇、2-(3,4-二羟基苯基)色满-3,5,7-三醇)。表儿茶素((2R,3R)-3,3',4',5,7-黄烷五醇)在本发明上下文中也是有利的活性成分。
还有利的是具有儿茶素类含量的植物提取物,尤其是绿茶提取物,如来自山茶属(Camellia)植物,非常具体为茶树品种茶树(Camellia sinenis)、大叶茶(C.assamica),大理茶(C.taliensis)和滇缅茶(C.inawadiensis)以及这些例如与山茶(Camelliajaponica)的杂交植物的的叶子的提取物。
优选的活性成分还有多酚类以及选自(-)-儿茶素、(+)-儿茶素、(-)-儿茶素没食子酸酯、(-)-没食子儿茶素没食子酸酯、(+)-表儿茶素、(-)-表儿茶素、(-)-表儿茶素没食子酸酯、(-)-表没食子儿茶素、(-)-表儿茶素没食子酸酯的儿茶素类。
黄酮及其衍生物(通常也统称为“黄酮类”)在本发明上下文中也是有利的活性成分。
其他优选的活性成分是丝氨酸苷、吡哆醇、维生素K、生物素和芳香物质,红没药醇(外消旋红没药醇(购自BASF)),生育酚(T-50C(购自BASF)),视黄醇棕榈酸酯(Vitamin A-Palmitate Care(购自BASF)),视黄醇(Retinol 50C(购自BASF)),五味子(Schizandra Chinensis Fruit Extract)果提取物(/>LS 9905(购自BASF))。
此外,活性成分还可以非常有利地选自亲水性活性成分,尤其是下组:α-羟基酸,如乳酸或水杨酸及其盐,如乳酸钠、乳酸钙、TEA乳酸盐、尿素、尿囊素、丝氨酸、山梨糖醇、乳蛋白、泛醇、壳聚糖、甘油和甘油葡糖苷(例如Aquaporin(购自BASF))或其组合。
可以用于本发明双相化妆品组合物中的所述活性成分和活性成分组合的列举当然并不意欲是限制性的。活性成分可以单独或以任何相互组合使用。
活性成分可以取决于其类型而以本领域中的常规量存在于本发明双相组合物中。本领域熟练技术人员能够选择适合本发明的活性成分和量。
可以用于本发明双相化妆品组合物中的所述和其他活性成分在DE 103 18 526A1第12-17页给出,其整体在此作为参考。
其他有益剂
本发明组合物可以进一步包含一种或多种可以对待护理基体,例如皮肤提供正面和/或有益效果的有益剂。本领域熟练技术人员能够根据配制化妆品组合物领域的常识以及与其相关的大量文献选择适合应用目的的该类任选成分。
在一个实施方案中,本发明组合物进一步包含一种或多种有益剂,如润肤剂,润湿剂,调理剂,皮肤调理剂,如维生素或其衍生物,如复合维生素B,包括硫胺素、烟酸、生物素、泛酸、胆碱、核黄素、维生素B6、维生素B12、吡哆醇、肌醇、肉毒碱,维生素A、C、D、E、K及其衍生物,如维生素A棕榈酸酯,以及维生素原,例如泛醇(维生素原B5),泛醇三乙酸酯及其混合物;抗氧化剂;自由基清除剂;天然或合成磨料;染料;染发剂;漂白剂;漂发剂;UV吸收剂,如二苯甲酮、波尼酮、PABA(对氨基苯甲酸)、PABA丁酯、肉桂酰胺丙基三甲基氯化铵、二苯乙烯基联苯二磺酸二钠、甲氧基肉桂酸钾;防UV剂,如丁基甲氧基二苯甲酰甲烷、甲氧基肉桂酸辛酯、氧苯酮、奥克立林、水杨酸辛酯、苯基苯并咪唑磺酸、羟丙基氨基苯甲酸乙酯、邻氨基苯甲酸薄荷酯、氨基苯甲酸、西诺沙酯、二乙醇胺甲氧基肉硅酸盐、氨基苯甲酸甘油、二氧化钛、氧化锌、氧苯酮、二甲基PABA辛酯(二甲氨苯酸辛酯)、红色矿脂;抗微生物剂;抗菌剂,如杆菌肽、红霉素、三氯生、新霉素、四环素、金霉素、苄索氯铵、苯酚、对氯间二甲酚(PCMX)、三氯卡班(TCC)、葡萄糖酸氯己定(CHG)、吡啶硫酮锌、硫化硒;抗真菌剂;黑素调节剂;晒黑促进剂;脱色剂,如类视黄醇类如视黄醇,曲酸及其衍生物,如曲酸二棕榈酸酯,氢醌及其衍生物如熊果苷,氨甲环酸,维生素如尼克酸,维生素C及其衍生物,壬二酸,胎盘,甘草精,提取物如洋甘菊和绿茶,其中优选视黄醇、曲酸和氢醌;皮肤增亮剂如氢醌,儿茶酚及其衍生物,抗坏血酸及其衍生物;皮肤着色剂,如二羟基丙酮;脂肪调节剂;减重剂;祛痘剂;抗脂溢剂;抗衰老剂;防皱剂;角质层分离剂;抗炎剂;祛痘剂,如维甲酸、异维甲酸、莫维A胺、阿达帕林、他扎罗汀、壬二酸、视黄醇、水杨酸、过氧化苯甲酰、间苯二酚,抗生素如四环素及其异构体,红霉素,抗炎剂如布洛芬、萘普生、hetprofen,植物提取物如水冬瓜、山金草、茵陈蒿、细辛根、金盏花、春黄菊、nidium、聚合草、茴香、五倍子、山楂、鱼腥草、贯叶连翘、枣、奇异果、甘草精、木兰、橄榄、薄荷、喜林芋、鼠尾草、维奇氏箬竹,咪唑类如酮康唑和新康唑;清新剂;结瘢剂;血管保护剂;减少头屑的试剂(去屑剂),脂溢性皮炎或银屑病,如吡啶硫酮盐,其由重金属如锌、锡、镉、镁、铝、钠和锆形成,如吡啶硫酮锌,页岩油及其衍生物如磺化页岩油,硫化硒,硫,水杨酸,煤焦油,聚维酮碘,咪唑类如酮康唑,二氯苯基咪唑并二氧戊环,克霉唑,伊曲康唑,咪康唑,咪菌酮,噻康唑,硫康唑,布康唑,氟康唑,亚硝酸咪康唑及其任何可能的立体异构体和衍生物如地蒽酚,吡罗克酮乙醇胺(Octopirox),硫化硒,环吡司胺,抗银屑病药如维生素D类似物,例如钙泊三醇、钙三醇和tacaleitrol,维生素A类似物如维生素A的酯,包括维生素A棕榈酸酯,类视黄醇类,视黄醇类和视黄酸,皮质类固醇类如皮质醇,氯倍他松丁酸盐,丙酸氯倍他索;止汗剂或祛臭剂,如氯化羟铝、氯化羟铝锆;免疫调节剂;营养剂;脱毛剂,如巯基乙酸钙、巯基乙酸镁、巯基乙酸钾、巯基乙酸锶;防脱发剂;永久卷发还原剂;反射剂,如云母、氧化铝、硅酸钙、二醇二油酸酯、二醇二硬脂酸酯、二氧化硅、氟硅酸钠镁;精油和香料。
本发明组合物的pH通常可以调节为例如4.0-7.0,优选4.5-6.5,更优选5.0-6.0。
本发明在第四方面提供了本发明双相化妆品组合物作为化妆品活性成分的输送系统的用途。
在本发明双相化妆品组合物中,油相和水相中的至少一个含有在皮肤上呈化妆品活性的活性成分。
对于活性成分,应理解的是合适的活性成分及其在该组合物中的量与前文所述的那些相同。
本发明在第五方面提供了一种施用本发明包含化妆品活性成分的双相化妆品组合物的方法,包括振摇该组合物以形成宏观均匀混合物并将该混合物施用于皮肤。
已经发现本发明双相化妆品组合物可以同时对皮肤输送水基和油基成分而获得非常柔软和新鲜感觉。本发明双相化妆品组合物可以以使得在油性组分量降低下保留各自益处的方式输送各相的组分。本发明双相化妆品组合物含有降低量的可能对皮肤具有意想不到的有害影响并且具有生物积累问题的表面活性剂。
实施例
通过下列实施例更全面说明本发明的各方面,阐述这些实施例是为了说明本发明的某些方面并且并不意欲构成对其的限制。
在实施例中使用下列材料和评价方法。
材料:
使用表1中所示材料。
表1
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制备双相化妆品组合物:
双相化妆品组合物按如下制备并且各材料的重量百分数如下表所示。
1.在搅动下于75-80℃的温度下将油相的各组分加入水相的各组分中,然后均化几分钟,形成均匀溶液。
2.在均化之后,在缓慢搅动下冷却至室温,在该溶液中加入油相和水相的各组分以外的组分并搅拌至均匀。
相分离评价方法:
该双相化妆品组合物的水相透明度可以通过视觉验证。
结果示于表2-5和图1-3中。在表2-5中,相A包括水相的各组分,相B包括油相的各组分,相C包括脂肪醇聚氧化烯醚和表面活性剂并且相D包括活性成分。
表2
表3
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表4
表5
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由表2-5和图1-3可以看出,在本发明实施例1-14中,两个分开的相作为乳液相和清澈水相存在,其中静止时乳液相漂浮在清澈水相之上并且形成这两相的清晰分离面;而在对比例1-3中,在水相出现絮凝物或者水和油分离,没有形成包含乳液相和清澈水相的双相化妆品组合物。
尽管上面描述了本公开的实施方案和实施例,但本领域熟练技术人员应理解它们仅是为了说明的目的并且并不意欲限制本公开的保护范围。本公开的保护范围由所附权利要求书限定。本领域熟练技术人员可以在不背离本发明范围和要旨下对这些实施方案进行各种改性、等同替换或改进,但这些改性、等同替换或改进落入本公开的保护范围内。
Claims (19)
1.一种双相化妆品组合物,包含式R-O-(R’)nH的脂肪醇聚氧化烯醚,其中R为饱和或不饱和的线性或支化C8-C22烃链或者饱和或不饱和的线性或支化C8-C22烃链的混合物,优选饱和或不饱和的线性或支化C10-C20烃链或者饱和或不饱和的线性或支化C10-C20烃链的混合物,更优选饱和或不饱和的线性或支化C12-C18烃链或者饱和或不饱和的线性或支化C12-C18烃链的混合物,R’选自氧亚乙基和氧亚丙基及其组合,优选氧亚乙基并且n为2-30,优选10-30,更优选15-30,其中两个分开的相作为乳液相和清澈水相存在并且优选所述脂肪醇聚氧化烯醚基于所述双相化妆品组合物的总重量以0.001-1.0重量%,优选0.005-0.2重量%,更优选0.01-0.15重量%,甚至更优选0.03-0.1重量%的量存在。
2.根据权利要求1的双相化妆品组合物,其中所述脂肪醇聚氧化烯醚包括脂肪醇聚氧乙烯醚,选自鲸蜡硬脂醇聚醚系列,如鲸蜡硬脂醇聚醚-2至鲸蜡硬脂醇聚醚-30,优选鲸蜡硬脂醇聚醚-10、鲸蜡硬脂醇聚醚-20或鲸蜡硬脂醇聚醚-30,更优选鲸蜡硬脂醇聚醚-20或鲸蜡硬脂醇聚醚-30;鲸蜡醇聚醚系列,如鲸蜡醇聚醚-2至鲸蜡醇聚醚-30,优选鲸蜡醇聚醚-10、鲸蜡醇聚醚-20或鲸蜡醇聚醚-30,更优选鲸蜡醇聚醚-20或鲸蜡醇聚醚-30;硬脂醇聚醚系列,如硬脂醇聚醚-2至硬脂醇聚醚-30,优选硬脂醇聚醚-10、硬脂醇聚醚-20或硬脂醇聚醚-30,更优选硬脂醇聚醚-20或硬脂醇聚醚-30;以及月桂醇聚醚系列,如月桂醇聚醚-2至月桂醇聚醚-30,优选月桂醇聚醚-10、月桂醇聚醚-20或月桂醇聚醚-30,更优选月桂醇聚醚-20或月桂醇聚醚-30;脂肪醇聚氧丙烯醚,选自PPG-10鲸蜡基醚、PPG-28鲸蜡基醚、PPG-30鲸蜡基醚和PPG-11硬脂基醚;以及还有脂肪醇聚氧乙烯-聚氧丙烯醚,选自PPG-4鲸蜡硬脂醇聚醚-12、PPG-4鲸蜡硬脂醇聚醚-20、PPG-10鲸蜡硬脂醇聚醚-20、PPG-4鲸蜡醇聚醚-1、PPG-4鲸蜡醇聚醚-5、PPG-4鲸蜡醇聚醚-10、PPG-4癸醇聚醚-4、PPG-5鲸蜡醇聚醚-20、PPG-8鲸蜡醇聚醚-1、PPG-8鲸蜡醇聚醚-2、PPG-8鲸蜡醇聚醚-5、PPG-8鲸蜡醇聚醚-10、PPG-8鲸蜡醇聚醚-20和PPG-9硬脂醇聚醚-3。
3.根据权利要求1或2的双相化妆品组合物,进一步包含在所述乳液相中的油组分,其中所述油组分包含烃和烃衍生物、甘油酯、醚、酯、碳酸酯、脂肪醇、脂肪酸、脂肪酸酯、脂肪醇醚、植物油、动物油、硅油、矿物油(石蜡油)及其组合。
4.根据权利要求3的双相化妆品组合物,其中所述脂肪醇选自具有6-22个,优选10-20个,更优选12-18个碳原子的饱和或不饱和的支化或未支化醇,例如格尔伯特醇,包括2-丁基辛醇、2-己基癸醇、2-丁基辛醇和2-己基癸醇的混合物、鲸蜡醇、硬脂醇、鲸蜡硬脂醇、油醇、辛基十二烷醇,优选鲸蜡醇、硬脂醇、鲸蜡硬脂醇、油醇、辛基十二烷醇,更优选鲸蜡硬脂醇。
5.根据权利要求3或4的双相化妆品组合物,其中所述油组分以1-20重量%,优选2-18重量%,更优选3-16重量%,进一步更优选3-12重量%的量存在。
6.根据权利要求4的双相化妆品组合物,其中所述脂肪醇聚氧化烯醚与脂肪醇的重量比为1:10-10:1,优选1:8-5:1,更优选1:5-1:1。
7.根据权利要求1-6中任一项的双相化妆品组合物进一步包含至少一种选自阴离子表面活性剂和两性表面活性剂的表面活性剂。
8.根据权利要求7的双相化妆品组合物,其中所述阴离子表面活性剂包括硫酸盐阴离子表面活性剂、氨基酸阴离子表面活性剂、磺基琥珀酸盐阴离子表面活性剂和磺化脂肪酸和/或二盐阴离子表面活性剂。
9.根据权利要求8的双相化妆品组合物,其中所述硫酸盐阴离子表面活性剂包括月桂基硫酸铵、月桂醇聚醚硫酸铵、三乙胺月桂基硫酸盐、三乙胺月桂醇聚醚硫酸盐、单乙醇胺月桂基硫酸盐、单乙醇胺月桂醇聚醚硫酸盐、二乙醇胺月桂基硫酸盐、二乙醇胺月桂醇聚醚硫酸盐、三乙醇胺月桂基硫酸盐、三乙醇胺月桂醇聚醚硫酸盐、甘油单月桂酸酯硫酸钠、月桂基硫酸钠、月桂醇聚醚硫酸钠、月桂基硫酸钾、月桂醇聚醚硫酸钾、椰油酰硫酸铵、月桂酰硫酸铵、椰油酰硫酸钠、月桂酰硫酸钠、椰油酰硫酸钾、月桂酰硫酸钾、鲸蜡硬脂基硫酸铵、鲸蜡硬脂基硫酸钠、鲸蜡硬脂基硫酸钾及其组合,优选月桂醇聚醚硫酸铵、月桂醇聚醚硫酸钠、月桂醇聚醚硫酸钾、鲸蜡硬脂基硫酸铵、鲸蜡硬脂基硫酸钠和鲸蜡硬脂基硫酸钾,更优选月桂醇聚醚硫酸钠和鲸蜡硬脂基硫酸钠。
10.根据权利要求8的双相化妆品组合物,其中所述氨基酸阴离子表面活性剂包括酰基谷氨酸盐、酰基牛磺酸盐、酰基甘氨酸盐、酰基丙氨酸盐、酰基肌氨酸盐和酰基天冬氨酸盐。
11.根据权利要求8的双相化妆品组合物,其中所述磺基琥珀酸盐阴离子表面活性剂包括磺基琥珀酸二辛酯钠、月桂醇聚醚磺基琥珀酸酯二钠、月桂醇磺基琥珀酸酯二钠、鲸蜡硬脂醇磺基琥珀酸酯二钠、磺基琥珀酸亚十一烷基酰胺基MEA二钠和PEG-5月桂醇柠檬酸酯磺基琥珀酸酯二钠,优选月桂醇磺基琥珀酸酯二钠和鲸蜡硬脂醇磺基琥珀酸酯二钠,更优选鲸蜡硬脂醇磺基琥珀酸酯二钠。
12.根据权利要求8的双相化妆品组合物,其中所述磺化脂肪酸和/或二盐阴离子表面活性剂为式(1)化合物:
R0CH(SO3M1)COOM2(1)
其中R0为饱和或不饱和的线性或支化C8-C16烃链以及M1和M2独立地为H、Li、Na、K、Ca/2、Mg/2、铵或链烷醇胺。
13.根据权利要求7-12中任一项的双相化妆品组合物,其中所述阴离子表面活性剂基于所述双相化妆品组合物的总重量以0.001-5重量%,优选0.005-1重量%,更优选0.006-0.5重量%,最优选0.01-0.1重量%的量存在。
14.根据权利要求7-13中任一项的双相化妆品组合物,其中所述两性表面活性剂包括酰基两性基乙酸钠、酰基两性基二丙酸二钠、烷基两性基二乙酸二钠、酰基两性基羟丙基磺酸钠、酰基两性基二乙酸二钠、酰基两性基丙酸钠和N-椰油脂肪酸酰胺基乙基N-羟乙基甘氨酸钠盐;N-烷基氨基酸,例如氨丙基烷基谷氨酰胺、烷基氨基丙酸、烷基酰亚胺基二丙酸钠和月桂酰两性基羧基甘氨酸盐;烷基甜菜碱、烷基酰胺基丙基甜菜碱、烷基磺基甜菜碱、烷基甘氨酸盐、烷基羧基甘氨酸盐、烷基两性基乙酸盐或-丙酸盐、烷基两性基二乙酸盐或-二丙酸盐,优选椰油基二甲基磺基丙基甜菜碱、月桂基甜菜碱、椰油酰胺基丙基甜菜碱或椰油酰两性基丙酸钠,更优选椰油酰胺基丙基甜菜碱。
15.根据权利要求7-14中任一项的双相化妆品组合物,其中所述两性表面活性剂以0.001-5重量%,优选0.005-1重量%,更优选0.006-0.5重量%,最优选0.01-0.1重量%的量存在。
16.根据权利要求1-15中任一项的双相化妆品组合物,进一步包含至少一种化妆品活性成分。
17.一种制备根据权利要求1-16中任一项的双相化妆品组合物的方法,包括混合所述双相化妆品组合物的各组分。
18.根据权利要求1-16中任一项的双相化妆品组合物作为化妆品活性成分的输送系统的用途。
19.一种施用根据权利要求1-16中任一项的双相化妆品组合物的方法,包括振摇所述组合物以形成宏观均匀混合物并将所述混合物施用于皮肤。
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