CN117732611A - Heparin sodium crude product extraction device and extraction method - Google Patents
Heparin sodium crude product extraction device and extraction method Download PDFInfo
- Publication number
- CN117732611A CN117732611A CN202410191417.4A CN202410191417A CN117732611A CN 117732611 A CN117732611 A CN 117732611A CN 202410191417 A CN202410191417 A CN 202410191417A CN 117732611 A CN117732611 A CN 117732611A
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- rod
- centrifugal
- cavity
- heparin sodium
- separation
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- 238000000605 extraction Methods 0.000 title claims abstract description 42
- 229920000669 heparin Polymers 0.000 title claims abstract description 29
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 title claims abstract description 29
- 229960001008 heparin sodium Drugs 0.000 title claims abstract description 29
- 239000012043 crude product Substances 0.000 title claims abstract description 23
- 230000005540 biological transmission Effects 0.000 claims abstract description 11
- 238000000926 separation method Methods 0.000 claims description 42
- 238000005119 centrifugation Methods 0.000 claims description 12
- 230000000903 blocking effect Effects 0.000 claims description 9
- 238000005192 partition Methods 0.000 claims description 8
- 238000007790 scraping Methods 0.000 claims description 8
- 238000003860 storage Methods 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 230000004308 accommodation Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 238000011068 loading method Methods 0.000 description 6
- 238000001125 extrusion Methods 0.000 description 5
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 4
- 235000017491 Bambusa tulda Nutrition 0.000 description 4
- 241001330002 Bambuseae Species 0.000 description 4
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 4
- 239000011425 bamboo Substances 0.000 description 4
- 244000309464 bull Species 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
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- Centrifugal Separators (AREA)
Abstract
The invention provides a heparin sodium crude product extraction device and an extraction method, and belongs to the technical field of heparin sodium crude product extraction. The heparin sodium crude product extraction device comprises a table body, wherein the extraction mechanism comprises a centrifugal barrel, a centrifugal cavity, a first moving groove, a first plugging plate, a transmission rod, a rotary table, a sliding groove, a sliding block, a limiting groove and a power rod, the centrifugal barrel is rotatably arranged at the bottom of the inner wall of the table body, and the centrifugal cavity is formed in the top of the centrifugal barrel. According to the invention, the extraction mechanism is arranged, the hydraulic rod is started to drive the ejector rod to move upwards, the power rod slides through the cooperation of the rotary table, the transmission rod pulls the first plugging plate to release plugging, the ejector rod continues to move upwards to drive the centrifugal barrel to move upwards, the centrifugal barrel is fed through the feeding nozzle to the inside of the centrifugal cavity, after the centrifugal barrel is returned to the original position by reversely starting the hydraulic rod, and the first motor is started to centrifuge the solution, so that the problem that the feeding is needed manually and the production efficiency is influenced is solved.
Description
Technical Field
The invention relates to the technical field of heparin sodium crude product extraction, in particular to a heparin sodium crude product extraction device and an extraction method.
Background
Heparin sodium is a natural anticoagulant and is usually extracted from the body of animals, most commonly porcine small intestine, and the preparation process of heparin sodium involves multiple steps including extraction, purification and processing, and during extraction, the steps of crushing, dissolving, centrifuging and purifying are needed.
When the existing equipment is used for centrifuging the solution, the solution is required to be manually injected into the test tubes, then the solution is placed into the centrifuge for centrifugation, a large amount of time is wasted, the production efficiency is affected, the solution is manually injected to easily cause the difference between the amounts of the solution in each test tube to be too large, the centrifugal effect is affected, and after the centrifugation is finished, workers are required to separate the centrifuged solution from residues through the pipettors, so that extra equipment cost and manpower resources are paid.
Disclosure of Invention
In order to overcome the defects, the invention provides a heparin sodium crude product extraction device and an extraction method for overcoming the technical problems or at least partially solving the problems.
The invention is realized in the following way:
the invention provides a heparin sodium crude product extraction device, which comprises a table body;
an extraction mechanism, the extraction mechanism comprising;
the centrifugal cylinder is rotatably arranged at the bottom of the inner wall of the table body;
the centrifugal cavity is formed at the top of the centrifugal cylinder;
the first moving groove is formed in the centrifugal barrel;
the first plugging plate is rotatably arranged in the first moving groove and penetrates into the centrifugal cavity;
the transmission rod is rotatably arranged at the top of the first plugging plate;
the rotary table is rotatably arranged in the centrifugal barrel;
the sliding groove is formed in the top of the turntable;
the sliding block is slidably arranged in the sliding groove;
the limiting groove is formed in the centrifugal barrel;
the power rod is slidably arranged in the limiting groove, and the bottom of the power rod is rotationally connected with the top of the transmission rod;
uniform feeding mechanism, uniform feeding mechanism sets up the top at the stage body inner wall.
In a preferred scheme, the uniform feeding mechanism comprises;
the communicating pipe is fixedly arranged at the top of the inner wall of the table body;
the accommodating disc is fixedly arranged at the bottom of the communicating pipe;
the accommodating cavity is arranged in the accommodating disc and is communicated with the inner cavity of the communicating pipe;
a partition plate fixedly installed inside the accommodating chamber;
the feeding nozzle is fixedly arranged at the bottom of the accommodating disc, and the inner cavity of the feeding nozzle is communicated with the accommodating cavity;
and the separation mechanism is arranged on the surface of the centrifugal barrel.
In a preferred embodiment, the separation mechanism comprises;
the separation box is fixedly arranged on the surface of the centrifugal barrel;
the separation cavity is arranged in the separation box;
the filter screen is fixedly arranged on the inner wall of the separation cavity.
In a preferred scheme, the top fixed mounting of a centrifugal barrel has the kicking block, the kicking block with offer the kicking groove between the centrifugal barrel, the inside slidable mounting of kicking groove has the ejector pin, the thread groove has been seted up on the surface of ejector pin, the ejector pin cover is established the inside of carousel, the bottom fixed mounting of a centrifugal barrel has the rotary drum, the internally mounted of rotary drum has the hydraulic stem, the top of hydraulic stem with the bottom fixed connection of ejector pin, the inside fixed mounting of stage body has first motor, the output of first motor with the bottom fixed connection of rotary drum.
In a preferred scheme, the top fixed mounting of platform body has the storage box, the inner chamber of storage box with the inner chamber of communicating pipe is linked together, the surface mounting of communicating pipe has first valve, the bottom fixed mounting who holds the dish has the fixed shell, the first spring is installed at the top of fixed shell inner wall, the other end fixed mounting of first spring has the loading shoe.
In a preferred scheme, the bottom wall of holding the dish has seted up the second and has removed the groove, the inside slidable mounting of second removes the groove has the second shutoff board, the right side fixed mounting of second shutoff board has the voussoir, the other end fixed mounting of voussoir has the second spring, the other end of second spring with the fixed surface of shell is connected, the fixed surface of carrier block installs the loading board, the top fixed mounting of loading board has the carrier bar.
In a preferred scheme, the bottom of centrifugal cavity inner wall rotates and installs the bull stick, the fixed surface of bull stick installs the connecting rod, one side that the connecting rod is close to the separation cavity inner wall fixed mounting has and cuts the pole of rubbing, cut the pole of rubbing with the inner wall in centrifugal cavity contacts.
In a preferred scheme, the bottom fixed mounting of bull stick has first gear, the inside rotation of centrifugal section of thick bamboo is installed the ring gear, the ring gear with first gear meshing is connected, the inside fixed mounting of centrifugal section of thick bamboo has the second motor, the output fixed mounting of second motor has the second gear, the second gear with the ring gear meshing is connected.
In a preferred scheme, the surface fixed mounting of a centrifugal barrel has the connecting pipe, the inner chamber and the separation chamber of connecting pipe are all linked together with the centrifugal chamber, the surface mounting of connecting pipe has the second valve, the inside slidable mounting in separation chamber has the drawer, the left side fixed mounting of drawer has the handle, the left side rotation of separation box installs the locking lever.
The heparin sodium crude product extraction method is suitable for a heparin sodium crude product extraction device and comprises the following steps:
s1: work preparation: starting a hydraulic rod, enabling the first plugging plate to rotate to expose the separation cavity, and enabling the ejector rod to move up the centrifugal cylinder;
s2: and (3) feeding preparation: after the bearing block is extruded by the ejector block, the second plugging plate is moved, and the separation cavity is fed through the feeding nozzle;
s3: and (3) centrifuging: the hydraulic rod drives the centrifugal cylinder to return to the original position, the first plugging plate plugs the centrifugal cavity, and the first motor is started to enable the centrifugal cylinder to rotate for centrifugation;
s4: cleaning: after the centrifugation is finished, the first motor is closed, the second motor is started, and the rotating rod drives the scraping rod to scrape and clean the inner wall of the centrifugal cavity;
s5: and (3) finishing the work: when the rubbing rod rotates, the separated solution passes through the connecting pipe, unnecessary residues in the solution are filtered, and the treated solution falls into the drawer.
The invention provides a heparin sodium crude product extraction device and an extraction method, which have the beneficial effects that:
1. through setting up extraction mechanism, start the hydraulic stem, drive ejector pin upward movement, make the power pole slip through the cooperation of carousel, transfer lever pulling first shutoff board, the shutoff is relieved, the ejector pin continues upward movement and drives the centrifugal section of thick bamboo upward movement, carry out the material loading to the inside of centrifugal chamber through the charging spout, reverse start hydraulic stem makes the centrifugal section of thick bamboo get back to the normal position after finishing, start first motor, make the solution carry out the centrifugation to the problem that needs the manual work to carry out the material loading has been solved, influence production efficiency.
2. Through setting up even feed mechanism, when the ejector pin drove kicking block upward movement, the kicking block caused the extrusion to the carrier block, makes the carrier block drive loading board and carrier bar upward movement, causes the extrusion to the wedge piece, because the shape of voussoir sets up to the slope, the voussoir drives the second shutoff board and removes, no longer holds the chamber shutoff, makes the solution that holds the intracavity portion and need carry out centrifugation drop to the inside in centrifugal chamber through a plurality of charging nozzles even to solution volume is too big mutually, causes the problem of influence to centrifugal effect has been solved.
3. Through setting up separating mechanism, start the second motor, make the ring gear rotatory, first gear drives the bull stick and snatchs the pole rotatory with cutting, makes centrifugal liquid and the residue that finishes enter into the inside of separation chamber through the connecting pipe through centrifugal force, intercepts the residue through the cooperation of filter screen, and pure solution falls into the inside of drawer to the staff still need be through the auxiliary problem that just can separate pure solution and residue of equipment such as pipettor after having solved the centrifugation.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some examples of the present invention and therefore should not be considered as limiting the scope, and other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic perspective view of an embodiment of the present invention;
FIG. 2 is a partial cross-sectional view of a table provided in accordance with an embodiment of the present invention;
FIG. 3 is a partial cross-sectional view of a centrifuge bowl according to an embodiment of the present invention;
FIG. 4 is a partial cross-sectional view of an embodiment of the present invention providing a containment tray;
FIG. 5 provides an enlarged view of a portion of FIG. 4 at A in accordance with an embodiment of the present invention;
FIG. 6 is a partial cross-sectional view of an embodiment of the present invention providing a containment disc and a stationary housing;
FIG. 7 is a partial cross-sectional view of a centrifuge bowl and a separation cassette provided in accordance with an embodiment of the present invention;
fig. 8 is a partial enlarged view of fig. 7 at B according to an embodiment of the present invention.
In the figure: 1. a table body; 2. a centrifugal barrel; 3. a centrifugal chamber; 4. a first moving groove; 5. a first plugging plate; 6. a transfer lever; 7. a turntable; 8. a chute; 9. a slide block; 10. a limit groove; 11. a power lever; 12. a communicating pipe; 13. a receiving tray; 14. a receiving chamber; 15. a partition plate; 16. a feeding nozzle; 17. a separation box; 18. a separation chamber; 19. a filter screen; 20. a top block; 21. a top groove; 22. a push rod; 23. a thread groove; 24. a rotating drum; 25. a hydraulic rod; 26. a first motor; 27. a storage box; 28. a first valve; 29. a fixed case; 30. a first spring; 31. a bearing block; 32. a second moving groove; 33. a second blocking plate; 34. wedge blocks; 35. a second spring; 36. a carrying plate; 37. a carrier bar; 38. a rotating rod; 39. a connecting rod; 40. cutting and rubbing the rod; 41. a first gear; 42. a gear ring; 43. a second motor; 44. a second gear; 45. a connecting pipe; 46. a second valve; 47. a drawer; 48. a handle; 49. a lock rod.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, based on the embodiments of the invention, which are apparent to those of ordinary skill in the art without inventive faculty, are intended to be within the scope of the invention.
Referring to fig. 1-8, the present invention provides a technical solution: the extraction mechanism comprises a centrifugal barrel 2, a centrifugal cavity 3, a first moving groove 4, a first blocking plate 5, a transmission rod 6, a rotary disc 7, a sliding groove 8, a sliding block 9, a limiting groove 10 and a power rod 11, wherein the centrifugal barrel 2 is rotatably arranged at the bottom of the inner wall of the platform body 1, the centrifugal cavity 3 is arranged at the top of the centrifugal barrel 2, the first moving groove 4 is arranged in the centrifugal barrel 2, the first blocking plate 5 is rotatably arranged in the first moving groove 4, the first blocking plate 5 penetrates into the centrifugal cavity 3, the transmission rod 6 is rotatably arranged at the top of the first blocking plate 5, the rotary disc 7 is rotatably arranged in the centrifugal barrel 2, the sliding groove 8 is arranged at the top of the rotary disc 7, the sliding block 9 is slidably arranged in the sliding groove 8, the limiting groove 10 is arranged in the centrifugal barrel 2, the power rod 11 is slidably arranged in the limiting groove 10, the bottom of the power rod 11 is rotationally connected with the top of the transmission rod 6, the uniform feeding mechanism is arranged at the top of the inner wall of the table body 1, the top of the centrifugal cylinder 2 is fixedly provided with a jacking block 20, a jacking groove 21 is formed between the jacking block 20 and the centrifugal cylinder 2, a jacking rod 22 is slidably arranged in the jacking groove 21, a thread groove 23 is formed in the surface of the jacking rod 22, the jacking rod 22 is sleeved in the turntable 7, the bottom of the centrifugal cylinder 2 is fixedly provided with a rotary drum 24, the inside of the rotary drum 24 is provided with a hydraulic rod 25, the top of the hydraulic rod 25 is fixedly connected with the bottom of the jacking rod 22, the inside of the table body 1 is fixedly provided with a first motor 26, the output end of the first motor 26 is fixedly connected with the bottom of the rotary drum 24, the hydraulic rod 25 is started through the arrangement of the extraction mechanism to drive the jacking rod 22 to move upwards, the turntable 7 is rotationally driven through the thread groove 23 and the threaded connection of the turntable 7, the shape of the chute 8 is arc, after the power rod 11 slides through the extrusion of the sliding chute 8 to the sliding block 9 and the matching of the limiting groove 10, the first plugging plate 5 is pulled through the transmission rod 6, and the first plugging plate 5 is rotated because the rotating connection of the first plugging plate 5 and the first moving groove 4 is set to be an eccentric position, so that the centrifugal cavity 3 is not plugged any more, the ejector rod 22 continues to move upwards until contacting the top of the inner wall of the ejector rod 21 and forming extrusion to drive the centrifugal cylinder 2 to move upwards, the inside of the centrifugal cavity 3 is fed through the feeding nozzle 16, after the centrifugal cylinder 2 returns to the original position, and conversely, the first plugging plate 5 plugs the centrifugal cavity 3 and starts the first motor 26 to centrifuge the solution, so that the problems that the feeding is required to be performed manually and the production efficiency is affected are solved;
referring to fig. 1 to 8, the uniform feeding mechanism includes a communicating pipe 12, a holding tray 13, a holding chamber 14, a partition plate 15 and a feeding nozzle 16, the communicating pipe 12 is fixedly installed at the top of the inner wall of the table body 1, the holding tray 13 is fixedly installed at the bottom of the communicating pipe 12, the holding chamber 14 is opened inside the holding tray 13, the holding chamber 14 is communicated with the inner cavity of the communicating pipe 12, the partition plate 15 is fixedly installed inside the holding chamber 14, the feeding nozzle 16 is fixedly installed at the bottom of the holding tray 13, the inner cavity of the feeding nozzle 16 is communicated with the holding chamber 14, the separation mechanism is arranged on the surface of the centrifugal barrel 2, the top of the table body 1 is fixedly installed with a storage box 27, the inner cavity of the storage box 27 is communicated with the inner cavity of the communicating pipe 12, the surface of the communicating pipe 12 is installed with a first valve 28, the bottom of the holding tray 13 is fixedly installed with a fixing shell 29, the top of the inner wall of the fixing shell 29 is installed with a first spring 30, the other end of the first spring 30 is fixedly provided with a bearing block 31, the bottom wall of the accommodating tray 13 is provided with a second moving groove 32, the inside of the second moving groove 32 is slidably provided with a second blocking plate 33, the right side of the second blocking plate 33 is fixedly provided with a wedge block 34, the other end of the wedge block 34 is fixedly provided with a second spring 35, the other end of the second spring 35 is fixedly connected with the surface of the fixed shell 29, the surface of the bearing block 31 is fixedly provided with a bearing plate 36, the top of the bearing plate 36 is fixedly provided with a bearing rod 37, the inside of the storage box 27 is filled with solution to be centrifuged in advance by arranging a uniform feeding mechanism, the first valve 28 is opened, the first valve 28 is closed after the solution is filled in the accommodating cavity 14, the inside of the accommodating cavity 14 is equally divided into a plurality of partition plates 15, the inside of the accommodating cavity 14 is equally divided, a gap between each two partition plates 15 is communicated with a feeding nozzle 16, the number of the second plugging plates 33, the second moving grooves 32, the wedge blocks 34, the second springs 35, the bearing plates 36 and the bearing rods 37 are all arranged corresponding to the feeding nozzles 16, when the ejector rod 22 drives the ejector block 20 to move upwards, the ejector block 20 extrudes the bearing block 31, so that the bearing block 31 drives the bearing plates 36 and the bearing rods 37 to move upwards, and extrudes the wedge blocks 34, and as the shape of the wedge blocks 34 is set to be inclined, the wedge blocks 34 drive the second plugging plates 33 to move, the containing cavity 14 is not plugged any more, and the solution to be centrifuged in the containing cavity 14 uniformly falls into the centrifugal cavity 3 through the feeding nozzles 16, so that the problems that the solution quantity is too large and the centrifugal effect is affected are solved;
referring to fig. 1 to 8, the separation mechanism comprises a separation box 17, a separation cavity 18 and a filter screen 19, the separation box 17 is fixedly arranged on the surface of a centrifugal barrel 2, the separation cavity 18 is arranged in the separation box 17, the filter screen 19 is fixedly arranged on the inner wall of the separation cavity 18, a rotating rod 38 is rotatably arranged at the bottom of the inner wall of the centrifugal barrel 3, a connecting rod 39 is fixedly arranged on the surface of the rotating rod 38, a scraping rod 40 is fixedly arranged on one side of the connecting rod 39, which is close to the inner wall of the separation cavity 18, the scraping rod 40 is contacted with the inner wall of the centrifugal barrel 3, a first gear 41 is fixedly arranged at the bottom of the rotating rod 38, a gear ring 42 is rotatably arranged in the centrifugal barrel 2, the gear ring 42 is in meshed connection with the first gear 41, a second motor 43 is fixedly arranged in the centrifugal barrel 2, a second gear 44 is fixedly arranged at the output end of the second motor 43, the second gear 44 is in meshed connection with the gear ring 42, a connecting pipe 45 is fixedly arranged on the surface of the centrifugal barrel 2, the inner cavity of the connecting pipe 45 and the separating cavity 18 are communicated with the centrifugal cavity 3, a second valve 46 is arranged on the surface of the connecting pipe 45, a drawer 47 is slidably arranged in the separating cavity 18, a handle 48 is fixedly arranged on the left side of the drawer 47, a lock rod 49 is rotatably arranged on the left side of the separating box 17, after the solution is centrifuged, a second motor 43 is started, the second valve 46 is opened, the gear ring 42 is rotated through meshed connection of the second gear 44 and the gear ring 42, the first gear 41 drives the rotating rod 38 and the scraping rod 40 to rotate through meshed connection of the first gear 41 and the gear ring 42, the inner wall of the centrifugal cavity 3 is cleaned, centrifuged liquid and residues enter the inside of the separating cavity 18 through the connecting pipe 45 through centrifugal force, the residues are intercepted through the cooperation of the filter screen 19, pure solution falls into the inside of the drawer 47, the drawer 47 can be pulled out by rotating the lock rod 49 to collect the pure solution, so that the problem that the pure solution and residues can be separated only by the aid of equipment such as a liquid transfer device by workers after centrifugation is solved;
the heparin sodium crude product extraction method is suitable for a heparin sodium crude product extraction device and comprises the following steps:
s1: work preparation: starting the hydraulic rod 25 to enable the first plugging plate 5 to rotate to expose the separation cavity 18, and then enabling the ejector rod 22 to enable the centrifugal barrel 2 to move upwards;
s2: and (3) feeding preparation: after the bearing block 31 is extruded by the top block 20, the second plugging plate 33 is moved, and the separation cavity 18 is fed through the feeding nozzle 16;
s3: and (3) centrifuging: the hydraulic rod 25 drives the centrifugal cylinder 2 to return to the original position, the first plugging plate 5 plugs the centrifugal cavity 3, and the first motor 26 is started to enable the centrifugal cylinder 2 to rotate for centrifugation;
s4: cleaning: after the centrifugation is finished, the first motor 26 is closed, the second motor 43 is started, and the rotating rod 38 drives the scraping rod 40 to scrape and clean the inner wall of the centrifugal cavity 3;
s5: and (3) finishing the work: when the rubbing rod 40 rotates, the separated solution passes through the connection pipe 45, unwanted residues in the solution are filtered, and the treated solution falls into the drawer 47.
Specifically, the working process or working principle of the heparin sodium crude product extraction device and the heparin sodium crude product extraction method are as follows: when in use, the hydraulic rod 25 is started to drive the ejector rod 22 to move upwards, the rotary table 7 is rotated by the threaded connection of the threaded groove 23 and the rotary table 7, the sliding groove 8 is arc-shaped, the first valve 28 is opened to enable the solution to fill the accommodating cavity 14, the first valve 28 is closed after the accommodating cavity 14 is fully filled with the solution, and a plurality of separating plates 15 are equally arranged inside the accommodating cavity 14 because the first sealing plate 5 is pulled by the transmission rod 6 and the first moving groove 4 is eccentrically connected, so that the first sealing plate 5 rotates and the centrifugal cavity 3 is not blocked, the ejector rod 22 continues to move upwards until the ejector rod 22 contacts the top of the inner wall of the ejector groove 21 and forms extrusion to drive the centrifugal cylinder 2 to move upwards, the inside of the accommodating cavity 14 is equally divided, a feeding nozzle 16 is communicated with gaps between every two separating plates 15, the number of the second plugging plates 33, the second moving grooves 32, the wedge blocks 34, the second springs 35, the bearing plates 36 and the bearing rods 37 are all arranged corresponding to the number of the feeding nozzles 16, when the ejector rod 22 drives the ejector rod 20 to move upwards, the ejector rod 20 extrudes the bearing blocks 31, the bearing blocks 31 drive the bearing plates 36 and the bearing rods 37 to move upwards, the wedge blocks 34 are extruded, the wedge blocks 34 drive the second plugging plates 33 to move due to the inclined shape of the wedge blocks 34, the accommodating cavity 14 is not plugged any more, so that the solution needing to be centrifuged in the accommodating cavity 14 uniformly falls into the centrifugal cavity 3 through the plurality of the feeding nozzles 16, after the solution is reversely started, the centrifugal cylinder 2 returns to the original position, and conversely, the first plugging plates 5 cause the centrifugal cavity 3, after the solution is centrifuged, the second motor 43 is started, the gear ring 42 is rotated through the meshed connection of the second gear 44 and the gear ring 42, the first gear 41 drives the rotating rod 38 and the scratch rod 40 to rotate through the meshed connection of the first gear 41 and the gear ring 42, the inner wall of the centrifugal cavity 3 is cleaned, centrifuged liquid and residues enter the separation cavity 18 through the connecting pipe 45, the residues are intercepted through the cooperation of the filter screen 19, the pure solution falls into the drawer 47, the drawer 47 can be pulled out by rotating the lock rod 49, and the pure solution is collected.
It should be noted that, the hydraulic rod 25, the first motor 26 and the second motor 43 are devices or apparatuses existing in the prior art, or are devices or apparatuses that can be implemented in the prior art, and the power supply, the specific composition and the principle thereof are clear to those skilled in the art, so they will not be described in detail.
Claims (10)
1. The utility model provides a heparin sodium crude extraction element, includes stage body (1), its characterized in that:
an extraction mechanism, the extraction mechanism comprising,
the centrifugal cylinder (2) is rotatably arranged at the bottom of the inner wall of the table body (1);
the centrifugal cavity (3) is formed in the top of the centrifugal cylinder (2);
the first moving groove (4) is formed in the centrifugal barrel (2);
the first blocking plate (5) is rotatably arranged in the first moving groove (4), and the first blocking plate (5) penetrates into the centrifugal cavity (3);
the transmission rod (6) is rotatably arranged at the top of the first plugging plate (5);
the rotary table (7), the said rotary table (7) rotates and installs in the inside of the centrifugal tube (2);
the sliding groove (8) is formed in the top of the rotary table (7);
the sliding block (9) is slidably arranged in the sliding groove (8);
the limiting groove (10) is formed in the centrifugal barrel (2);
the power rod (11) is slidably arranged in the limit groove (10), and the bottom of the power rod (11) is rotationally connected with the top of the transmission rod (6);
uniform feeding mechanism, uniform feeding mechanism sets up the top at stage body (1) inner wall.
2. The heparin sodium crude product extraction device of claim 1, wherein the uniform feeding mechanism comprises,
the communicating pipe (12), the said communicating pipe (12) is fixedly installed on top of the inner wall of the desk body (1);
a containing disc (13), wherein the containing disc (13) is fixedly arranged at the bottom of the communicating pipe (12);
the accommodating cavity (14) is formed in the accommodating disc (13), and the accommodating cavity (14) is communicated with the inner cavity of the communicating pipe (12);
a partition plate (15), the partition plate (15) being fixedly mounted inside the accommodation chamber (14);
the feeding nozzle (16) is fixedly arranged at the bottom of the accommodating disc (13), and the inner cavity of the feeding nozzle (16) is communicated with the accommodating cavity (14);
and the separation mechanism is arranged on the surface of the centrifugal barrel (2).
3. The heparin sodium crude extraction device of claim 2, wherein the separation mechanism comprises,
a separation box (17), wherein the separation box (17) is fixedly arranged on the surface of the centrifugal barrel (2);
a separation chamber (18), the separation chamber (18) being provided inside the separation box (17);
the filter screen (19), filter screen (19) fixed mounting is at the inner wall of separation chamber (18).
4. The heparin sodium crude product extraction device according to claim 3, characterized in that a jacking block (20) is fixedly installed at the top of the centrifugal barrel (2), a jacking groove (21) is formed between the jacking block (20) and the centrifugal barrel (2), a jacking rod (22) is slidably installed in the jacking groove (21), a thread groove (23) is formed in the surface of the jacking rod (22), the jacking rod (22) is sleeved in the rotary disc (7), a rotary drum (24) is fixedly installed at the bottom of the centrifugal barrel (2), a hydraulic rod (25) is installed in the rotary drum (24), the top of the hydraulic rod (25) is fixedly connected with the bottom of the jacking rod (22), a first motor (26) is fixedly installed in the interior of the table body (1), and the output end of the first motor (26) is fixedly connected with the bottom of the rotary drum (24).
5. The heparin sodium crude product extraction device according to claim 4, wherein a storage box (27) is fixedly installed at the top of the table body (1), an inner cavity of the storage box (27) is communicated with an inner cavity of the communicating pipe (12), a first valve (28) is installed on the surface of the communicating pipe (12), a fixing shell (29) is fixedly installed at the bottom of the containing disc (13), a first spring (30) is installed at the top of the inner wall of the fixing shell (29), and a bearing block (31) is fixedly installed at the other end of the first spring (30).
6. The heparin sodium crude product extraction device according to claim 5, wherein a second moving groove (32) is formed in the bottom wall of the accommodating disc (13), a second plugging plate (33) is slidably mounted in the second moving groove (32), a wedge block (34) is fixedly mounted on the right side of the second plugging plate (33), a second spring (35) is fixedly mounted at the other end of the wedge block (34), the other end of the second spring (35) is fixedly connected with the surface of the fixed shell (29), a bearing plate (36) is fixedly mounted on the surface of the bearing block (31), and a bearing rod (37) is fixedly mounted on the top of the bearing plate (36).
7. The heparin sodium crude product extraction device according to claim 6, wherein a rotating rod (38) is rotatably arranged at the bottom of the inner wall of the centrifugal cavity (3), a connecting rod (39) is fixedly arranged on the surface of the rotating rod (38), a scraping rod (40) is fixedly arranged on one side, close to the inner wall of the separation cavity (18), of the connecting rod (39), and the scraping rod (40) is in contact with the inner wall of the centrifugal cavity (3).
8. The heparin sodium crude product extraction device according to claim 7, wherein a first gear (41) is fixedly arranged at the bottom of the rotating rod (38), a gear ring (42) is rotatably arranged in the centrifugal barrel (2), the gear ring (42) is in meshed connection with the first gear (41), a second motor (43) is fixedly arranged in the centrifugal barrel (2), a second gear (44) is fixedly arranged at the output end of the second motor (43), and the second gear (44) is in meshed connection with the gear ring (42).
9. The heparin sodium crude product extraction device according to claim 8, wherein a connecting pipe (45) is fixedly arranged on the surface of the centrifugal barrel (2), an inner cavity of the connecting pipe (45) and the separation cavity (18) are communicated with the centrifugal cavity (3), a second valve (46) is arranged on the surface of the connecting pipe (45), a drawer (47) is slidably arranged in the separation cavity (18), a handle (48) is fixedly arranged on the left side of the drawer (47), and a lock rod (49) is rotatably arranged on the left side of the separation box (17).
10. A method for extracting crude heparin sodium, which is suitable for the device for extracting the crude heparin sodium according to any one of the claims 1 to 9, and is characterized by comprising the following steps:
s1: work preparation: starting a hydraulic rod (25), enabling the first plugging plate (5) to rotate to expose the separation cavity (18), and enabling the ejector rod (22) to enable the centrifugal barrel (2) to move upwards;
s2: and (3) feeding preparation: after the bearing block (31) is extruded by the ejector block (20), the second plugging plate (33) is moved, and the separation cavity (18) is fed through the feeding nozzle (16);
s3: and (3) centrifuging: the hydraulic rod (25) drives the centrifugal cylinder (2) to return to the original position, the first plugging plate (5) plugs the centrifugal cavity (3), and the first motor (26) is started to rotate the centrifugal cylinder (2) for centrifugation;
s4: cleaning: after centrifugation, the first motor (26) is closed, the second motor (43) is started, and the rotating rod (38) drives the scraping rod (40) to scrape and clean the inner wall of the centrifugal cavity (3);
s5: and (3) finishing the work: when the rubbing rod (40) rotates, the separated solution passes through the connecting pipe (45), unnecessary residues in the solution are filtered, and the treated solution falls into the drawer (47).
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