CN117729926A - 用于使碱基编辑器自失活的组合物和方法 - Google Patents

用于使碱基编辑器自失活的组合物和方法 Download PDF

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Publication number
CN117729926A
CN117729926A CN202280036220.2A CN202280036220A CN117729926A CN 117729926 A CN117729926 A CN 117729926A CN 202280036220 A CN202280036220 A CN 202280036220A CN 117729926 A CN117729926 A CN 117729926A
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seq
polynucleotide
intron
domain
base editor
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Chinese (zh)
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大卫·布赖森
杰克·苏利文
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Bim Medical Co ltd
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Bim Medical Co ltd
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04004—Adenosine deaminase (3.5.4.4)
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA

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  • Health & Medical Sciences (AREA)
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  • Cell Biology (AREA)
  • Mycology (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Dental Preparations (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202280036220.2A 2021-05-28 2022-05-27 用于使碱基编辑器自失活的组合物和方法 Pending CN117729926A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163194431P 2021-05-28 2021-05-28
US63/194,431 2021-05-28
PCT/US2022/031419 WO2022251687A2 (en) 2021-05-28 2022-05-27 Compositions and methods for the self-inactivation of base editors

Publications (1)

Publication Number Publication Date
CN117729926A true CN117729926A (zh) 2024-03-19

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CN202280036220.2A Pending CN117729926A (zh) 2021-05-28 2022-05-27 用于使碱基编辑器自失活的组合物和方法

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US (1) US20240132868A1 (https=)
EP (1) EP4346840A4 (https=)
JP (1) JP2024521750A (https=)
KR (1) KR20240012377A (https=)
CN (1) CN117729926A (https=)
AU (1) AU2022280952A1 (https=)
CA (1) CA3219628A1 (https=)
WO (1) WO2022251687A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118813611B (zh) * 2023-04-19 2025-09-16 清华大学 一种基于rna核酶的dear核酸操纵系统及其应用
WO2025111384A1 (en) * 2023-11-20 2025-05-30 Beam Therapeutics Inc. Compositions and methods for altering complement activation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9580727B1 (en) * 2015-08-07 2017-02-28 Caribou Biosciences, Inc. Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
CN110214183A (zh) * 2016-08-03 2019-09-06 哈佛大学的校长及成员们 腺苷核碱基编辑器及其用途
HUE070436T2 (hu) * 2017-10-23 2025-06-28 Stoke Therapeutics Inc Antiszensz oligomerek nonszensz-mediált RNS-lebomláson alapuló állapotok és betegségek kezelésére
CA3084185A1 (en) * 2017-12-06 2019-06-13 Generation Bio Co. Gene editing using a modified closed-ended dna (cedna)
KR20250133482A (ko) * 2018-05-11 2025-09-05 빔 테라퓨틱스, 인크. 프로그래밍가능한 염기 편집기 시스템을 이용하여 단일 뉴클레오티드 다형성을 편집하는 방법

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Publication number Publication date
WO2022251687A2 (en) 2022-12-01
JP2024521750A (ja) 2024-06-04
KR20240012377A (ko) 2024-01-29
EP4346840A2 (en) 2024-04-10
CA3219628A1 (en) 2022-12-01
AU2022280952A9 (en) 2023-11-30
WO2022251687A3 (en) 2023-01-19
AU2022280952A1 (en) 2023-11-23
US20240132868A1 (en) 2024-04-25
EP4346840A4 (en) 2025-06-04

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