CN117717721A - Neutron capture shielding device based on 3D technology and preparation method thereof - Google Patents
Neutron capture shielding device based on 3D technology and preparation method thereof Download PDFInfo
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- CN117717721A CN117717721A CN202410047867.6A CN202410047867A CN117717721A CN 117717721 A CN117717721 A CN 117717721A CN 202410047867 A CN202410047867 A CN 202410047867A CN 117717721 A CN117717721 A CN 117717721A
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- INAHAJYZKVIDIZ-UHFFFAOYSA-N boron carbide Chemical compound B12B3B4C32B41 INAHAJYZKVIDIZ-UHFFFAOYSA-N 0.000 claims description 11
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- 229910052796 boron Inorganic materials 0.000 description 5
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Abstract
The invention discloses a neutron capture shielding device based on a 3D technology and a preparation method thereof, and relates to the technical field of radiation protection, wherein the neutron capture shielding device comprises a body surface skin 3D model, a tumor 3D model and a forming combined die; the forming combined die is obtained by pouring and forming a basic combined die, and a center hollowed-out and pouring hole structure is designed in the basic combined die; the basic assembling die comprises a neutron irradiation plan navigation guide plate, a skin attaching device, a connecting device and a radioactive source receiving device, wherein one side of the radioactive source receiving device is connected with a neutron radioactive source, the other side of the radioactive source receiving device is connected with the connecting device, the skin attaching device is embedded in the connecting device, and the skin attaching device is sequentially connected with the neutron irradiation plan navigation guide plate and a tumor 3D model and is used for attaching with the body surface skin 3D model. The invention can design the individual shielding protection device according to the actual condition of the radiotherapy of the tumor of the patient, and the design is simple and easy.
Description
Technical Field
The invention relates to the technical field of radiation protection, in particular to a neutron capture shielding device based on a 3D technology and a preparation method thereof.
Background
Neutron Capture Therapy (NCT) is a binary chemo-radiation cancer treatment method that uses non-radioactive elements @ 10 B or Gd) and secondary charged particles generated after the neutron capture reaction to kill cancer cells. Although neutron capture therapy uses short neutron range, the neutron emission path is complex and variable, and these secondary particles will also interact with other normal tissue cells, causing harm to our health and environmental radiation pollution. Therefore, effective shielding and protection of neutrons and gamma rays become one of the key factors in the new generation of neutron capture therapies.
In the aspect of the existing neutron shielding material, the neutron shielding performance is better than that of boron carbide (B 4 C)， 10 Boron steel, lead plate, large-sized concrete, etc. which have a target of 3837 in the absorption cross section of B for thermal neutrons and have boron as an absorption main body have been used as a nuclear protection main body material. The boron-containing polyethylene plate is a neutron shielding material which is currently conventional, and is prepared by boron carbide (B 4 C) In (a) and (b) 10 The B element can efficiently absorb neutrons with low energy. However, the boron polyethylene materials sold in the market are produced by a batch process, complex components are difficult to be processed by secondary molding in the actual application process, personalized shielding in complex scenes cannot be realized, and the application effect is not ideal.
Therefore, how to solve the problem that the prior neutron shielding material is applied to a short plate to realize more individual shielding protection is a urgent need of the technicians in the field.
Disclosure of Invention
In view of the above, the invention provides a neutron capturing shielding device based on 3D technology and a preparation method thereof in order to solve the problems in the background art.
In order to achieve the above object, the present invention provides the following technical solutions:
a neutron capture shielding device based on a 3D technology comprises a body surface skin 3D model, a tumor 3D model and a forming combined die;
the forming combined die is obtained by pouring and forming a basic combined die, and a center hollowed-out and pouring hole structure is designed in the basic combined die;
the basic assembling die comprises a neutron irradiation plan navigation guide plate, a skin attaching device, a connecting device and a radioactive source receiving device, wherein one side of the radioactive source receiving device is connected with a neutron radioactive source, the other side of the radioactive source receiving device is connected with the connecting device, the skin attaching device is embedded in the connecting device, and the skin attaching device is sequentially connected with the neutron irradiation plan navigation guide plate and a tumor 3D model and is used for attaching with the body surface skin 3D model.
Optionally, the skin attaching device is designed according to the neutron irradiation plan navigation guide plate, and the body surface skin 3D model, the tumor 3D model and the neutron irradiation plan navigation guide plate are designed in a complete set according to the neutron radiation source and the tumor 3D model.
Optionally, the pouring molding process adopts a mixed solution of silica gel and a silica gel curing agent, and the mixed solution of silica gel and the silica gel curing agent is prepared according to the following steps: silica gel: the silica gel curing agent is prepared by uniformly stirring and mixing the silica gel curing agent and the silica gel at the ratio of 0.1:1:0.1, and heating and drying the silica gel at 60 ℃ for 12-20h.
Optionally, the skin attachment means, the connecting means, the radiation source receiving means are designed as adjustable replacement assembly means.
Optionally, a lead shielding shell is further arranged outside the basic combined die.
Optionally, the basic assembling die is formed by 3D printing, and the printing material is QSY white resin: high-density polyethylene resin, printing precision: minimum wall thickness requirement ± 0.15/100 mm: 0.3mm.
A preparation method of a neutron capture shielding device based on a 3D technology comprises the following steps:
reconstructing tumor and body surface skin of the patient according to the image data of the patient;
according to an irradiation area taking a tumor of a patient as a center, designing a neutron irradiation plan navigation guide plate;
designing a skin attaching device according to a neutron irradiation planning navigation guide plate;
according to the neutron radiation source and the tumor 3D model, designing a connecting device and a radiation source receiving device to form a basic combined die;
the method comprises the steps of (1) carrying out center hollowed-out and pouring hole design on a basic combined die, and carrying out 3D printing;
preparing a silica gel and a silica gel curing agent mixed boron carbide solution, and pouring and drying the basic combined die to obtain a formed combined die;
the body surface skin 3D model, the tumor 3D model and the forming combined die jointly form the neutron capture shielding device.
According to the technical scheme, the invention provides the neutron capture shielding device based on the 3D technology and the preparation method thereof, and compared with the prior art, the neutron capture shielding device has the following beneficial effects:
the invention can solve the problem that the prior neutron shielding material is limited by the application of the short plate, popularize the application of the 3D technology in the field of neutron radiation protection and overcome the problem that the prior boron-containing polyethylene shielding material is limited, and can design an individual shielding protection device according to the actual condition of radiotherapy of tumor of a patient.
The neutron capture shielding device based on the tumor shape of the individual patient is designed by using the scheme of the invention, is simple and easy to implement, has multiple components and flexible model assembly, is independently designed and manufactured, can be fused with individual and batch production, and has wide application prospect and economic value.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are required to be used in the embodiments or the description of the prior art will be briefly described below, and it is obvious that the drawings in the following description are only embodiments of the present invention, and that other drawings can be obtained according to the provided drawings without inventive effort for a person skilled in the art.
FIG. 1 (a) is a schematic illustration of an irradiation guidance guide with a neutron capture shielding device attached to a patient in an irradiation position;
FIG. 1 (b) is a schematic view of a tumor 3D model of a neutron capture shielding device attached to a patient at an irradiation site;
FIG. 2 is a schematic diagram of a neutron capture shielding device;
FIG. 3 is a schematic diagram of a transmitting source receiving device;
FIG. 4 is a schematic view of a connection device;
FIG. 5 is a schematic view of a skin attachment device;
FIG. 6 is a schematic illustration of a neutron irradiation planning navigation guidance board;
FIG. 7 is a schematic view of a tumor 3D model;
FIG. 8 is a schematic diagram of a 3D model of body surface skin;
FIG. 9 (a) is a diagram of DICOM image data of a patient;
FIG. 9 (b) is a diagram showing the tumor target area of a patient in a multi-modal manner;
FIG. 9 (c) is a schematic diagram of a reconstructed patient's skin tissue and tumor tissue;
FIG. 10 (a) is a schematic illustration of planning a guide plate based on skin and tumor tissue;
FIG. 10 (b) is a schematic diagram of a design shaped neutron irradiation plan navigation guide plate;
FIG. 11 (a) is a front view of a CAD black and white line of the neutron capture shielding device of FIG. 2;
FIG. 11 (b) is a perspective view of a CAD black and white line of the neutron capture shielding device of FIG. 2;
FIG. 11 (c) is a perspective view of a CAD black and white line at another angle to the neutron capture shielding device of FIG. 2;
FIG. 11 (d) is a top view of a CAD black and white line of the neutron capture shielding device of FIG. 2;
wherein 1 represents a tumor 3D model, 2 represents a neutron irradiation planning navigation guide plate, 3 represents a skin attaching device, 4 represents a connecting device, and 5 represents a radioactive source receiving device.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The 3D printing technology is one of the representatives of the current advanced manufacturing technology, and is widely applied to the aspects of aerospace, national defense, military, jewelry, biological medicine and the like. Based on the medical three-dimensional reconstruction technology, the personalized modeling is carried out through the image data of the patient, and the design and the manufacture of a personalized preoperative model, an operation guide plate, a rehabilitation brace and the like can be realized.
The embodiment of the invention discloses a neutron capture shielding device based on a 3D technology, which comprises a body surface skin 3D model, a tumor 3D model 1 and a forming combined die; the forming combined die is obtained by pouring and forming a basic combined die, and referring to fig. 2, fig. 11 (a) -fig. 11 (d) are schematic diagrams of CAD black and white lines of the neutron capture shielding device.
Referring to fig. 2, the basic assembling die comprises a neutron irradiation plan navigation guide plate 2, a skin attaching device 3, a connecting device 4 and a radioactive source receiving device 5, wherein one side of the radioactive source receiving device 5 is connected with a neutron radioactive source, the other side of the radioactive source receiving device is connected with the connecting device 4, the skin attaching device 3 is embedded in the connecting device 4, and the skin attaching device 3 is sequentially connected with the neutron irradiation plan navigation guide plate 2 and a tumor 3D model 1 and is used for attaching with a body surface skin 3D model.
The skin attaching device 3 is formed by shearing and designing a neutron irradiation plan navigation guide plate 2 according to the positioning and planning of the tumor 3D model 1. The body surface skin 3D model, the tumor 3D model 1 and the neutron irradiation plan navigation guide plate 2 are designed based on Sketch Sketch complete set design and according to neutron radiation source equipment conditions and the tumor 3D model 1.
The skin attachment means 3, the connecting means 4 and the radiation source receiving means 5 are designed as adjustable replacement assembly means. The connection device 4 is designed into various models of 10cm by 5cm, 10cm by 10cm, 15cm by 10cm, 20cm by 15cm, 30cm by 20cm and the like. The diameter of the radiation source receiving device 5 is designed to be one diameter according to the model of the machine.
In the specific implementation process, the height of the skin attaching device 3 is 15cm, the connecting device 4 is designed according to different models, the wall thickness is 1cm, the height is 15cm, and the radioactive source receiving device 5 is provided with a diameter according to the model of the machine, the wall thickness is 1cm, and the height is 15cm.
The basic assembling die is formed by 3D printing, and the printing material is QSY white resin: high-density polyethylene resin, printing precision: minimum wall thickness requirement ± 0.15/100 mm: 0.3mm.
In the specific implementation process, a lead shielding shell is arranged outside the basic combined die in consideration of the fact that neutrons and boron carbide possibly react to generate certain secondary gamma rays, and the thickness of the lead shielding shell can be set to be 5-20mm.
The method comprises the steps of designing a central hollowed-out and pouring hole structure in an obtained basic combined die, and pouring and forming by adopting a silica gel and silica gel curing agent mixed boron carbide solution, wherein the silica gel and the silica gel curing agent mixed boron carbide solution are prepared according to the following steps: silica gel: the silica gel curing agent is prepared by uniformly stirring and mixing the silica gel curing agent and the silica gel at the ratio of 0.1:1:0.1, and heating and drying the silica gel at 60 ℃ for 12-20h.
The invention also provides a preparation method of the neutron capture shielding device based on the 3D technology, which comprises the following steps:
rebuilding tumor and body surface skin of the patient: referring to fig. 9 (a) is patient DICOM image data, fig. 9 (b) is a multi-mode display of the tumor target area condition of the patient, main-stream medical three-dimensional reconstruction mimics software is utilized, a threshold tool "threshold" is utilized to respectively select proper tumor and body surface skin threshold values according to the patient DICOM image data, a Mask segmentation tool "split Mask" is utilized to segment a proper region of interest, edit and optimize are performed through tools such as "edit Mask", and finally 3D reconstruction of tumor and body surface skin is completed through a tool such as "cavity 3D from Mask", see fig. 9 (c).
Designing a neutron irradiation plan navigation guide plate 2: see fig. 10 (a) and 10 (b). (1) design and generation of a sheet bottom guide plate: the irradiation area centered on the tumor is marked by lasso through a "lasso area mark" tool, the area delineation follows the design principle of the radiation treatment plan, radiation treatment shielding optimization is realized, and the marked area is subjected to Copyto Part to separate the sheet body which can be independently edited. (2) bottom surface navigation guide plate optimization: the sheet body is Offset by 5mm to form a closed entity by using ' Design ' and ' Offset and ' form Offset ', and the neutron irradiation planning navigation guide plate 2 is designed by using ' Trim ', ' Fix ', ' Fill Hole Free ' and other commands to repair and optimize the Design.
The skin attachment device 3 is designed: (1) personalized skin fit design: (1) vertical sktech design and optimization at irradiation viewing angles: selecting 'Sketch' to construct a new design Sketch, and setting up a mask in the vertical direction of the planned irradiation view angle to construct the Sketch. According to the relative direction of the neutron irradiation plan navigation guide plate 2 and the sketch, the object coordinate system of the neutron irradiation plan navigation guide plate 2 is moved in an aligning mode, so that the neutron irradiation plan navigation guide plate 2 is separated from the guide plate, and vertical stretching operation can be achieved. And (3) carrying out sketch size design and optimization according to the relative sizes of the neutron irradiation plan navigation guide plate 2 and the sketch. (2) And (3) planning and individuating design according to the profile of the neutron irradiation planning navigation guide plate 2: selection of "ImportReferences to Sketch" in sktch selects neutron irradiation plan navigation guide 2"outline" based on Sketch to achieve personalized contour planning and materialize the contour line for presentation. (2) designing the skin attachment means 3 based on the inner contour line: the skin attaching device 3 is designed according to the outline of the neutron irradiation planning navigation guide plate 2 planned by a sketch, the size is required to effectively irradiate tumors based on a sketch Design rule rectangle, and the tumor is extended and stretched upwards by 150mm according to the irradiation direction based on the internal outline and the external outline through a Design-extrusion, so that a three-dimensional model is formed. And displaying the chest model, moving the cylindrical model to overlap with the patient contour model, and subtracting the patient contour from the cylindrical model by using a Design-subtleting tool, thereby completing the first part of the personalized irradiation device based on the patient skin and the radiotherapy planning guide plate contour line.
The connecting device 4 is designed: according to the tumor condition and the diameter of the machine emission source device, connecting devices 4 of different models are set up, the device can be repeatedly used, the device and the skin laminating device 3 are in a push-pull mode, and the device is tightly laminated based on sketch design to prevent rays from being emitted. On the basis of the outer contour of the skin attaching device 3, "Design-extension" is performed on the newly obtained contour and the original outer contour by using "skin-Tools-offset" to amplify by 5mm, respectively, wherein the original contour is stretched 180mm, the newly obtained contour is stretched 150mm, and the two are subjected to Boolean operation "Design-sub-section" to obtain the intermediate portion connecting device 4.
The radiation source receiving device 5 is designed: according to the emission source device, namely the irradiation equipment model, a receiving device which is the same as the emission source is designed by taking the center of a Sketch as the center of a circle, stretching is carried out on the Sketch by using a Design-extrusion, the height is 150mm, inward deflection is carried out on the Sketch by using a Sketch-Tools-Offest for 5mm, stretching of an inner cylinder is completed, the inner cylinder is moved to a 1/2 outer cylinder to be discharged by using an Align, and shearing calculation of the inner cylinder and the outer cylinder and a connecting device 4 is realized by using a Boolean operation Design-subtleting, so that the Design of the receiving device is completed.
And (3) carrying out center hollowed-out and pouring hole design on the basic combined die: according to the obtained basic combined die, through Hollow out design of the Hollow software design center, later pouring can be realized, pouring holes are formed in proper positions, the diameter of each pouring hole is slightly smaller than the wall thickness, the die cannot be perforated, and a plurality of pouring holes can be formed to facilitate quick pouring.
3D printing: and (3) exporting the designed basic combined die in an STL format, preprocessing in 3D printing slicing software, repairing a related model, generating a support, printing and forming in a photo-curing printer by using a QSY white resin material, performing support removing, cleaning, polishing and ultraviolet curing on the printed die, checking whether the die is hollowed out, and controlling the quality of the 3D printing model such as whether a pouring hole is unobstructed.
And preparing a silica gel and silica gel curing agent mixed boron carbide solution, and pouring and drying the basic combined die to obtain a formed combined die, so that the body surface skin 3D model, the tumor 3D model 1 and the formed combined die jointly form the neutron capture shielding device.
Considering that neutrons and boron carbide can react to generate certain secondary gamma rays, a lead shielding shell with the thickness of 5-20mm is designed on the main body device. The shielding material is to be shaped and fixed according to components such as the radioactive source receiving device 5 and the connecting device 4 in the main body device, and is used for shielding impure radioactive rays and gamma rays.
The device and the preparation method can be applied to neutron capture treatment, and can also be applied to other radiotherapy or shielding material design.
In the present specification, each embodiment is described in a progressive manner, and each embodiment is mainly described in a different point from other embodiments, and identical and similar parts between the embodiments are all enough to refer to each other.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (7)
1. The neutron capture shielding device based on the 3D technology is characterized by comprising a body surface skin 3D model, a tumor 3D model and a forming combined die;
the forming combined die is obtained by pouring and forming a basic combined die, and a center hollowed-out and pouring hole structure is designed in the basic combined die;
the basic assembling die comprises a neutron irradiation plan navigation guide plate, a skin attaching device, a connecting device and a radioactive source receiving device, wherein one side of the radioactive source receiving device is connected with a neutron radioactive source, the other side of the radioactive source receiving device is connected with the connecting device, the skin attaching device is embedded in the connecting device, and the skin attaching device is sequentially connected with the neutron irradiation plan navigation guide plate and a tumor 3D model and is used for attaching with the body surface skin 3D model.
2. The neutron capture shielding device based on the 3D technology according to claim 1, wherein the skin attaching device is designed according to the neutron irradiation plan navigation guide plate, and the body surface skin 3D model, the tumor 3D model and the neutron irradiation plan navigation guide plate are designed in a complete set according to a neutron radiation source and the tumor 3D model.
3. The neutron capture shielding device based on the 3D technology according to claim 1, wherein the process of pouring and molding adopts a silica gel and a silica gel curing agent mixed boron carbide solution, and the silica gel curing agent mixed boron carbide solution is prepared according to the following steps: silica gel: the silica gel curing agent is prepared by uniformly stirring and mixing the silica gel curing agent and the silica gel at the ratio of 0.1:1:0.1, and heating and drying the silica gel at 60 ℃ for 12-20h.
4. The neutron capture shielding device of claim 1, wherein the skin attachment means, the connection means, the radiation source receiving means are designed as adjustable replacement assembly means.
5. The neutron capture shielding device based on 3D technology of claim 1, wherein a lead shielding shell is further arranged outside the basic assembling die.
6. The neutron capture shielding device based on the 3D technology according to claim 1, wherein the base combined mold is formed by 3D printing, and the printing material is QSY white resin: high-density polyethylene resin, printing precision: minimum wall thickness requirement ± 0.15/100 mm: 0.3mm.
7. The preparation method of the neutron capture shielding device based on the 3D technology is characterized by comprising the following steps of:
reconstructing tumor and body surface skin of the patient according to the image data of the patient;
according to an irradiation area taking a tumor of a patient as a center, designing a neutron irradiation plan navigation guide plate;
designing a skin attaching device according to a neutron irradiation planning navigation guide plate;
according to the neutron radiation source and the tumor 3D model, designing a connecting device and a radiation source receiving device to form a basic combined die;
the method comprises the steps of (1) carrying out center hollowed-out and pouring hole design on a basic combined die, and carrying out 3D printing;
preparing a silica gel and a silica gel curing agent mixed boron carbide solution, and pouring and drying the basic combined die to obtain a formed combined die;
the body surface skin 3D model, the tumor 3D model and the forming combined die jointly form the neutron capture shielding device.
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| CN202410047867.6A CN117717721A (en) | 2024-01-12 | 2024-01-12 | Neutron capture shielding device based on 3D technology and preparation method thereof |
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| CN202410047867.6A CN117717721A (en) | 2024-01-12 | 2024-01-12 | Neutron capture shielding device based on 3D technology and preparation method thereof |
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| CN117717721A true CN117717721A (en) | 2024-03-19 |
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