CN102063569A - Target point arrangement method in treatment plan and treatment plan system - Google Patents
Target point arrangement method in treatment plan and treatment plan system Download PDFInfo
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Abstract
The invention discloses a target point arrangement method in a treatment plan, which comprises the process of arranging a treatment target point on a target body according to a focus in a patient. The process comprises the steps of: A, selecting parameters for target point arrangement; B, constructing a target body voxel model; C, constructing a target body depth indexing model according to the target body voxel model; D, selecting a maximum depth index value region in the target body depth indexing model for target point arrangement; E, carrying out dosage calculation according to the target point arrangement; F, updating the target body voxel model according to a dosage calculating result; G, repeating the steps from C to F until the maximum depth indexing value in the target body depth indexing model is less than the first preset indexing value or the number of iterations is more than the preset number of iterations; and H, outputting a target point arrangement result. The invention also discloses a treatment plan system. Through introducing the depth indexing model into the target point arrangement method, the dosage target volume rate is increased, the local control to tumors is improved, the damage to the peripheral health tissues is reduced, and the treatment effect is improved.
Description
Technical field
The present invention relates to radiocurable dosage planning, relate in particular to a kind of treatment plan point of impact on target method for arranging and treatment planning systems.
Background technology
Stereotactic radiotherapy operation or stereotactic radiotherapy are two kinds of common in radiation therapy radiation therapy technologies, and common equipment is based on the gamma knife of cobalt-60 radioactive source and based on the X cutter of electron accelerator.The former usually adopts a plurality of cobalts-60 radioactive source to focus on the mode of irradiation, makes target body accept the uniform irradiation of high dose and surrounding health tissue's amount of being subjected to is very low to reach control or to eradicate the purpose of pathology.Utilize gamma knife treatment equipment to implement to make an acceptable radiotherapy treatment planning usually before the radiation therapy.When formulating treatment plan, doctor and physics teacher need be according to the volume and the shapes of target body, determine the target spot number, adjust the position of each target spot, the collimating apparatus size of each target spot correspondence and the parameters such as relative weighting of each target spot, to obtain the treatment plan of the suitable shape of an overall situation.Because the parameter that relates to is a lot, especially when the big and out-of-shape of volume of target body, when perhaps the contiguous unsoundness of target body was organized, this was a very time-consuming process, and experience and the technical ability to the planned personnel requires very high simultaneously.
In order to address this problem, just need the automatic planning of dosage.When the automatic planing method of predose mainly is divided into two classes.First kind method is, the dosage field (selecting 50% isodose usually) that each target spot is formed is approximately the ball or the ellipsoid of a rigidity, carries out the automatic layout of target spot then by the mode of filling the target body volumes for how much.Whole filling process is not need to carry out Rapid Dose Calculation based on dimensional measurement fully.Shortcoming is need carry out Rapid Dose Calculation at last to plan with affirmation.The dosage field mutual superposition is to the influence of overall dosage field between the target spot owing to ignored, and filling the plan that obtains automatically may exist than mistake with the dosage field of reality.Another kind method is that the target spot with a plurality of default weights is positioned some predeterminated position in the target body, and the position by these default target spots of iteration optimization mode Automatic Optimal, relative weighting are to obtain the dosage planning of the suitable shape of an overall situation then.Because Rapid Dose Calculation is very consuming time, in order to quicken the process of whole iteration optimization, usually in iteration, adopt the Rapid Dose Calculation model of simplifying, perhaps only selected part target body profile/critical tissue's point is calculated, and the plan that so last optimization obtains also obtains dosage field with reality and has error.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, provide a kind of error that can reduce to improve the target spot method for arranging of optimizing efficient.
Another object of the present invention is to provide a kind of treatment planning systems based on said method.
For achieving the above object, the present invention has adopted following technical scheme:
A kind of treatment plan target spot method for arranging comprises that treatment is preceding in treatment plan, treats the process that target spot is arranged according to the focus in the patient body on target body, and described process comprises:
Steps A: select to carry out the parameter that target spot is arranged, described parameter comprises prescribed dose, collimating apparatus specification, default iterations and minimum target body depth indexing;
Step B: make up the target body voxel model according to patient's target body outline data, described target body voxel model voxel value adopts two value defineds, and described two value defineds identify respectively in the outer and target body of target body;
Step C: make up target body depth indexing model according to described target body voxel model, described depth indexing's model comprises the depth information of voxel in the target body;
Step D: select depth capacity index value zone in described target body depth indexing model, collimating apparatus or the collimator arrangement of selecting default isodose surface width to be fit in the collimating apparatus specification of described selection are carried out the target spot layout;
Step e: carry out Rapid Dose Calculation according to described target spot layout;
Step F: according to the Rapid Dose Calculation result described target body voxel model is upgraded, the acquisition dose value is set to outside the target body more than or equal to the voxel of described prescribed dose, and dose value is set in the target body less than the voxel of prescribed dose;
Step G: repeating step C to the depth capacity index value of step F in target body depth indexing model less than the first default index value or iterations greater than default iterations;
Step H: the output target spot is arranged the result.
Two-value among the wherein said step B is defined as the outer voxel value of target body and is set to 0, and the voxel value in the target body is set to 1;
Wherein said step C comprises:
Step C1: duplicate described target body voxel model, form target body depth indexing model;
Step C2: with the voxel value in the described target body depth indexing model be 1 and adjacent voxels at least one voxel value be 0 be set to 1, all the other are set to 0;
Step C3: in described target body depth indexing model, in the described target body voxel model voxel value be 1 and corresponding depth indexing's model in voxel value be that the voxel value of 0 voxel is set to: adjacent minimum non-zero voxel value+1; If adjacent all voxel values are 0, then be set to 0;
Step C4: repeating step C3, till voxel value is 1 voxel value non-0 in all corresponding described target body voxel models in described target body depth indexing model.
The maximum index value of wherein said step D is a voxel value maximum in the described target body depth indexing model.
Wherein said step D comprises:
Step D1: the voxel of in described target body depth indexing model, selecting to have maximum voxel value;
Step D2: the minimum distance that calculates described voxel and be 1 voxel to voxel value with maximum voxel value;
Step D3: arrange target spot on described voxel with maximum voxel value, the collimating apparatus of described target spot is default isodose surface width and the immediate collimating apparatus of described minimum distance in the collimating apparatus specification of described selection.
Also comprise before the wherein said step D: make up dose modals such as collimating apparatus, the described dose modal that waits comprises that each collimating apparatus presets the value of isodose surface on coordinate axis;
Wherein said step D comprises: selection depth capacity index value zone in described target body depth indexing model, carry out the target spot layout in the described collimating apparatus of selecting default isodose surface width to be fit in the dose modal that waits.
The wherein said dose modal that waits comprises that also collimator arrangement presets the value of isodose surface on coordinate axis;
Wherein said step D also comprises: selection depth capacity index value zone in described target body depth indexing model, carry out the target spot layout in the described collimator arrangement of selecting default isodose surface width to be fit in the dose modal that waits.
A kind of treatment planning systems, be used for the dosage planning before patient carries out radiation therapy, comprise target spot layout module, be used on target body, arranging target spot according to the target body profile information and export target spot layout result that in treatment plan described target spot arranges that module comprises target body voxel cell, target body depth indexing unit, parameter set unit, cloth target unit, Rapid Dose Calculation unit and iteration unit;
Described target body voxel cell is used for making up the target body voxel model according to patient's target body outline data, and described target body voxel model adopts two value defineds, and described two value defineds identify respectively in the outer and target body of target body;
Described target body depth indexing unit is used for making up target body depth indexing model according to described target body voxel model, and described depth indexing's model comprises the depth information of voxel in the target body;
Described parameter set unit is used to select to carry out the parameter that target spot is arranged, described parameter comprises prescribed dose, collimating apparatus specification, default iterations and the minimum target body degree of depth;
Described cloth target unit is used for selecting depth capacity index value zone at described target body depth indexing model, and collimating apparatus or the collimator arrangement of selecting the isodose surface width to be fit in the collimating apparatus specification of described selection are carried out the target spot layout;
Described Rapid Dose Calculation unit is used for carrying out Rapid Dose Calculation according to the target spot layout;
Described target body voxel cell also is used for upgrading the back in the Rapid Dose Calculation result and according to the Rapid Dose Calculation result described target body voxel model is upgraded, the acquisition dose value is set to outside the target body more than or equal to the voxel of prescribed dose, and dose value is set in the target body less than the voxel of prescribed dose;
Described iteration unit is used for after the target body voxel cell is upgraded described target body voxel model, call described target body depth indexing unit, cloth target unit, Rapid Dose Calculation unit successively, the depth capacity index value in described target body depth indexing model less than the first default index value or iterations greater than default iterations.
Wherein said target body depth indexing unit also is used for:
Duplicate described target body voxel model, form target body depth indexing model; With the voxel value in the described target body depth indexing model be 1 and adjacent voxels at least one voxel value be 0 be set to 1, all the other are set to 0; In described target body depth indexing model, in the described iteratively target body voxel model voxel value be 1 and corresponding depth indexing's model in voxel value be that the voxel value of 0 voxel is set to: adjacent minimum non-zero voxel value+1; If adjacent all voxel values are 0, then be set to 0, till voxel value is 1 voxel value non-0 in all corresponding described target body voxel models in described target body depth indexing model;
Wherein said maximum index value is a voxel value maximum in the described target body depth indexing model.
Wherein said cloth target unit also is used for: the voxel of selecting to have maximum voxel value at described target body depth indexing model; Calculate described voxel and be the minimum distance of 1 voxel to voxel value with maximum voxel value; Arrange target spot on described voxel with maximum voxel value, the collimating apparatus of described target spot is default isodose surface width and the immediate collimating apparatus of described minimum distance in the collimating apparatus specification of described selection.
Described system also comprises etc. and to be used to make up dose modals such as collimating apparatus in the dose modal unit, and the described dose modal that waits comprises that each collimating apparatus presets the value of isodose surface on coordinate axis; Described cloth target unit also is used for carrying out the target spot layout in described target body depth indexing model selection depth capacity index value zone in the described collimating apparatus of selecting default isodose surface width to be fit in the dose modal that waits.
The wherein said dose modal that waits comprises that also collimator arrangement presets the value of isodose surface on coordinate axis;
Described cloth target unit also is used for:
The target spot layout is carried out in the described collimator arrangement of selecting default isodose surface width to be fit in the dose modal that waits in selection depth capacity index value zone in described target body depth indexing model.
Owing to adopted above technical scheme, the beneficial effect that the present invention is possessed is:
(1) the present invention has added Rapid Dose Calculation in the target spot placement process, and according to the Rapid Dose Calculation of reality as a result iteration arrange target spot, reduced error; By introducing depth indexing's model and bringing in constant renewal in, increased the dosage conformal degree that target spot is arranged, increased part control to the target body tumour, reduce damage simultaneously to peripheral health tissues, improve result of treatment; Reduce iterations simultaneously, improved optimization efficient, reduced the time cost of treatment plan, improved the efficient of radiation therapy process;
(2) target body depth indexing model of the present invention takes into full account the features of shape of target body, by repeatedly scanning the depth information that obtains target body, has improved the conformal degree that target spot is arranged, further improves result of treatment;
(3) the present invention is by making up the isodose surface model, and the user can customize different dose modals such as target spot, has further improved optimization efficient;
(4) the present invention is by the renewal to voxel model, and the voxel that dosage in the target body is not reached prescribed dose carries out the target spot layout, has further improved the conformal degree that target spot is arranged.
Description of drawings
Fig. 1 illustrates the process flow diagram of the embodiment of treatment plan point of impact on target method for arranging according to the present invention;
Fig. 2 illustrates the process flow diagram of another embodiment of treatment plan point of impact on target method for arranging according to the present invention;
Fig. 3 illustrates the synoptic diagram according to the target body profile interpolation of another embodiment of the inventive method;
Fig. 4 illustrates the synoptic diagram according to the target body voxelization of another embodiment of the inventive method;
Fig. 5 illustrates the synoptic diagram according to the target body depth indexing model of another embodiment of the inventive method;
Fig. 6 a illustrates the synoptic diagram according to target body voxel model in the target body depth indexing model construction of another embodiment of the inventive method;
Fig. 6 b-Fig. 6 e illustrates the synoptic diagram that carries out depth scan according to target body in the target body depth indexing model construction of another embodiment of the inventive method;
Fig. 6 f illustrates according to all directions in the target body depth indexing model construction of another embodiment of the inventive method the synoptic diagram of effect of depth;
Fig. 7 illustrates the synoptic diagram according to depth capacity index value zone in the target body depth indexing model of another embodiment of the inventive method;
Fig. 8 a illustrates according to the local synoptic diagram that protrudes of the target body of another embodiment of the inventive method;
Fig. 8 b illustrates the synoptic diagram according to the local bifurcated of target body of another embodiment of the inventive method;
Fig. 9 illustrates the synoptic diagram according to the renewal target body voxel model of another embodiment of the inventive method;
Figure 10 illustrates the synoptic diagram according to the renewal target body depth indexing model of another embodiment of the inventive method;
Figure 11 illustrates the structural representation of the embodiment of treatment planning systems according to the present invention.
Embodiment
In the treatment plan, after the target body definition, need arrange the target spot of treatment usefulness on target body, the information of target spot comprises the collimating apparatus specification of target position, target spot and the segmental arc of target spot etc.In the process of arranging target spot, need to consider that the suitable shape to target body covers, just allow dose distribution consistent as far as possible, so just radiological dose as much as possible can be projected on the target body, and few as far as possible dosage is projected surrounding health tissue and jeopardizes on the organ with the shape of target body.Jeopardize the organ that organ mainly is meant needs special protection, for head, mainly comprise eyes, brain stem etc., comprise spinal cord etc. for body.
In conjunction with the accompanying drawings the present invention is described in further detail below by embodiment.
Fig. 1 illustrates the process flow diagram of the embodiment of treatment plan point of impact on target method for arranging according to the present invention, comprising:
Step 102: select to carry out the parameter that target spot is arranged, this parameter comprises prescribed dose, collimating apparatus specification, default iterations and minimum target body depth indexing;
Step 104: make up the target body voxel model according to patient's target body outline data, this target body voxel model voxel value adopts two value defineds, and described two value defineds identify respectively in the outer and target body of target body;
Step 106: make up target body depth indexing model according to the target body voxel model, this depth indexing's model comprises the depth information of voxel in the target body;
Step 108: in target body depth indexing model, select depth capacity index value zone, in the collimating apparatus specification of selecting, select suitable collimating apparatus of default isodose surface width or collimator arrangement to carry out target spot and arrange;
Step 110: carry out Rapid Dose Calculation according to the target spot layout;
Step 112; According to the Rapid Dose Calculation result target body voxel model is upgraded, the acquisition dose value is set to outside the target body more than or equal to the voxel of described prescribed dose, and dose value is set in the target body less than the voxel of prescribed dose;
Step 114: repeating step 106 to the depth capacity index value of step 112 in target body depth indexing model less than the first default index value or iterations greater than default iterations;
Step 116: the output target spot is arranged the result.
A kind of embodiment, wherein the two-value in the step 104 is defined as the outer voxel value of target body and is set to 0, and the voxel value in the target body is set to 1;
Wherein step 106 comprises:
Step 1062: duplicate the target body voxel model, form target body depth indexing model, in fact be exactly with the target body voxel model as target body depth indexing model initially;
Step 1064: with the voxel value in the target body depth indexing model be 1 and adjacent voxels at least one voxel value be 0 be set to 1, the voxel value of all the other voxels is set to 0;
Step 1066: in target body depth indexing model, in the target body voxel model voxel value be 1 and corresponding depth indexing's model in voxel value be that the voxel value of 0 voxel is set to: adjacent minimum non-zero voxel value+1; If adjacent all voxel values are 0, then be set to 0;
Step 1068: repeating step 1066, till voxel value is 1 voxel value non-0 in all corresponding described target body voxel models in target body depth indexing model.
Wherein the maximum index value in the step 108 is a voxel value maximum in the target body depth indexing model.
A kind of embodiment, wherein the first default index value can be set to 1, and default iterations can be provided with according to the target spot number that will arrange, for example is made as 30.
A kind of embodiment, step 108 further comprises:
Step 1082: in target body depth indexing model, select to have the voxel of maximum voxel value, promptly have the voxel of depth capacity index value;
Step 1084: the minimum distance that calculates this voxel and be 1 voxel to voxel value with maximum voxel value;
Step 1086: arrange target spot on this has the voxel of maximum voxel value, the collimating apparatus of described target spot is default isodose surface width and the immediate collimating apparatus of described minimum distance in the collimating apparatus specification of described selection.If it is a plurality of that the voxel with maximum voxel value has, then choose arbitrarily or select relatively in the middle of one.
Also can comprise before a kind of embodiment, step 108:
Step 107: make up dose modals such as collimating apparatus, these dose modals comprise that each collimating apparatus presets the value of isodose surface on coordinate axis;
Step 108 also comprises: select depth capacity index value zone in target body depth indexing model, the collimating apparatus of selecting default isodose surface width to be fit in these dose modals is carried out target spot and is arranged.
A kind of embodiment, its medium dose modal comprise that also collimator arrangement presets the value of isodose surface on coordinate axis;
Step 108 also comprises: select depth capacity index value zone in target body depth indexing model, the collimator arrangement of selecting default isodose surface width to be fit in waiting dose modal is carried out target spot and is arranged.
Those skilled in the art should understand that, the step of present embodiment and diagram are exemplary, the numbering of its step is not construed as limiting the invention, the order of some step can change, for example step 102 can be arranged on any moment of arranging before the target spot, need being arranged on before the step 108 or the like of step 107.
Fig. 2 illustrates the process flow diagram of another embodiment of treatment plan point of impact on target method for arranging according to the present invention, comprising:
Step 202: create different collimating apparatuss and combination thereof etc. dose modal;
In the present embodiment, according to the collimating apparatus number of radiotherapy equipment support, with ball mould (head ball mould: diameter R=100cm ball mould; Body ball mould: standard die body diameter R=260cm ball mould), also can adopt the ball mould of other diameters or the die body of other shapes.By dosage simulation create different collimating apparatuss and combination thereof etc. dose modal.Consider in the practical application, general 50% the isodose/bread network target body that adopts, the dose modal that waits Deng dose modal selection 50%, the i.e. dose distribution model that forms of 50% isodose/face, those skilled in the art should understand that, also can adopt the isodose/face of other ratios, as 55%, 60% etc.Simulation result is kept at one and waits in the dose modal tabulation, is convenient to search.
With SGS-II is example, and this equipment is supported 0.8cm, 1.5cm, 2.5cm, 4.0cm, five kinds of dissimilar collimating apparatuss of 5.5cm, and by adopting the simulation of standard ball mould, it is as follows to create out the corresponding dose modal that waits:
A: simulate different collimating apparatuss and combination thereof etc. dose distribution;
B: according to analog result, dose modals such as structure, as shown in table 1:
Dose modal tabulations such as table 1:50%
Rx/Ry/Rz adopted the width means of 50% isodose/face on three orthogonal directionss of the standard ball mould centre of sphere usually in the table 1.Single target spot simulation places target spot the standard ball mould centre of sphere usually, combination target spot simulation is the benchmark target spot that distributes symmetrically and evenly with the standard ball mould centre of sphere usually, and the layout of target position will guarantee that dosage field is symmetrical with respect to the standard ball mould centre of sphere, and each isodose is continuous simultaneously.As required, can revise, edit above-mentioned tabulation, also can create the new dose modal that waits and add in the above-mentioned tabulation according to new dosage field analog result.
Step 204: input patient positioning image sequence, delineate the outline of patient's body surface, target body, tissue of interest etc.;
Step 206: the target spot arrangement parameter is set;
Prescribed dose line P
d: generally select 50% isodose;
Target body coverage rate (Coverage) PTV
c: for prescribed dose envelope target body volume accounts for the number percent of target body cumulative volume, be typically chosen in 95%;
The minimum-depth index value;
Target spot is arranged default iterations: N automatically
t
Step 208: structure target body 3D voxel model;
According to the 2D target body outline that the user delineates on the positioning sequence image, structure target body 3D voxel model is as follows:
A: interpolation target body outline;
Usually during location scanning, the bed thickness of employing or interlamellar spacing are more a lot of greatly than the Pixel Dimensions of positioning image, in order to construct the 3D voxel model of target body, need carry out interpolation to the target body outline, as shown in Figure 3, and S
nAnd S
N+1Be two adjacent positioning images, irregular figure is the target body outline of delineating, S
iBe S
nAnd S
N+1Between certain new images and the new target body profile thereof that obtain by interpolation.
B: by voxelization structure target body 3D voxel model;
After the target body outline carried out interpolation, the voxelization of target body profile is promptly obtained the 3D voxel model of target body, as shown in Figure 4, P represents voxel among the figure, and target body 3D voxel model needs sufficiently high resolution to obtain a good result to guarantee that follow-up target spot is arranged usually.A kind of selectable resolution is to adopt the resolution of patient's positioning image, and this resolution is generally 0.5mm-1mm.
Step 210: structure target body 3D depth indexing model;
According to target body 3D voxel model, from the target body body surface, calculate target body case depth index from outside to inside, construct its 3D depth indexing model, as shown in Figure 5.
Fig. 6 a, Fig. 6 b, Fig. 6 c, Fig. 6 d, Fig. 6 e and Fig. 6 f show an embodiment who sets up depth indexing's model, the wherein P among Fig. 6 f
cRepresent current voxel.
Shown in Fig. 6 a, show the 3D voxel model, set up inside and outside identifier, dose value in the target body is made as 0 greater than the 3D voxel of prescribed dose or the identifier of the outer 3D voxel of target body, dose value is made as 1 less than the 3D voxel identifier of prescribed dose in the target body.
Shown in Fig. 6 b, depth indexing's value (integer of 1～n) is set.Scan inside and outside all the 3D voxels of target body earlier, with identifier in all voxels is 1, as long as and an above identifier is arranged in the six direction adjacent voxels of front, back, left, right, up, down is that 0 voxel depth indexing value is made as 1, other depth indexing's value all 0 is shown in Fig. 6 f.
Illustrated among Fig. 6 b and all depth indexing's values are set have been made as 1 voxel, again with reference to figure 6c, next index value be set be 2 voxel, with identifier in all voxels is 1, depth indexing's value still is 0, as long as and above depth indexing's value is arranged in the six direction adjacent voxels of front, back, left, right, up, down is that 1 voxel depth indexing value is made as 2.
Illustrated among Fig. 6 c and all depth indexing's values are set have been made as 2 voxel, again with reference to figure 6d, next index value be set be 3 voxel, with identifier in all voxels is 1, depth indexing's value still is 0, as long as and above depth indexing's value is arranged in the six direction adjacent voxels of front, back, left, right, up, down is that 2 voxel depth indexing value is made as 3.
So circulation is till depth indexing's value of 1 3D voxel all sets up up to current all identifiers.The depth indexing of Xing Chenging is shown in Fig. 6 e at last.
Step 212: select to be used for the collimating apparatus specification that target spot is arranged.
Can be according to the consideration of actual target body shape, size or clinical treatment aspect, when selection adopts the collimating apparatus of different size to carry out the target spot layout.For example:, can select the collimating apparatus of F0.8cm and two specifications of F1.5cm or select the collimating apparatus of F0.8cm, F1.5cm and three specifications of F2.5cm to carry out the target spot layout for certain target body.
Step 214: target spot is arranged.
(1) select depth capacity index value zone: search target body 3D depth indexing model, determine that the depth indexing is worth maximum zone, as thick line part among Fig. 7.For the target body of some special shape, may exist a plurality of depth indexings to be worth maximum zone.
(2) determine the target spot predetermined manner.
Search for target body 3D depth capacity index value, and determine current target spot predetermined manner according to this index value.If target body 3D depth capacity index value, enters the 2D target spot less than certain threshold value and arranges flow process; Otherwise enter the 3D target spot and arrange flow process.Target body 3D depth indexing is worth " the 3D thickness " of having represented target body.Smaller when target body 3D depth capacity index value, illustrate that target body " approaches " very much, need enter the 2D target spot and arrange flow process.This threshold value be chosen as usually minimum collimating apparatus size half, as being 0.4cm among the SGS-II.
1. the 3D target spot is arranged flow process.
Determine target body 3D depth capacity index value zone.If there is a depth capacity index value zone, then can select one or select first depth capacity index value zone at random.
The specification (being the collimating apparatus size) and the array mode of cloth target spot treated in selection.Dose modals such as inquiry, according to waiting target body depth capacity index value of determining in the 50% isodose width and above-mentioned steps in the dose modal to select suitable collimating apparatus, and treat that as current the target spot of cloth or its combination carry out the target spot layout with its target spot specification and array mode.
Consider the synergistic effect of dosage field between the target spot, and the shape of actual dose field 3D sphere not necessarily, in order to avoid occurring not right dosage field stack " space " or " overlapping " in the target spot placement process as far as possible, during dose modals such as selection, need the parameters R x/Ry/Rz on three directions of dose modal X/Y/Z such as consideration.Usually select minimum value and depth capacity index value among the Rx/Ry/Rz approaching etc. dose modal.
For example: for SGS-II, because the similar cake of simulation dosage field, wherein Rx minimum.Like this, current target body depth capacity index value is 4, waits the Rz=4.2cm of single target spot F2.5cm correspondence in the dose modal storehouse, and the then current cloth target spot for the treatment of can be selected the collimating apparatus of a F2.5 to carry out target spot and arrange.The current cloth target spot for the treatment of is: a target spot, collimating apparatus specification are F2.5cm, 0 °-360 ° of ranges of exposures, and weight is 100.
2. the 2D target spot is arranged flow process: this flow process is primarily aimed at the target body regional area and carries out the target spot layout.These zones are concavo-convex corresponding to the target body part, bifurcated or part such as discrete, and the thick line shown in Fig. 8 a partly is a projection, and the thick line shown in Fig. 8 b partly is a forked section.
In this example, its 3D depth indexing model is shown in Fig. 6 e, in view of the size of the depth value of these regional areas in target body 3D depth indexing model less than minimum collimating apparatus, usually corresponding 1 figure layer thickness adopts 2D depth indexing model to carry out target spot at these regional areas for this reason and arranges.Calculate the 2D depth indexing model of target body regional area; 2D depth capacity index value in the search target body regional area, and with this depth capacity index value position as the position for the treatment of the cloth target spot.If have a depth capacity index value zone, then can select one at random.The specification (being the collimating apparatus size) and the array mode of cloth target spot treated in selection.Dose modals such as inquiry, according to waiting target body 2D depth capacity index value preference pattern of determining in the 50% isodose width (mainly being Rx and Ry) and above-mentioned steps in the dose modal here, and carry out target spot with its target spot specification and array mode as the current target spot for the treatment of cloth or its combination and arrange.
Step 216: Rapid Dose Calculation.
Target spot according to determining comprises information such as position, collimating apparatus specification, utilizes the Rapid Dose Calculation engine to carry out Rapid Dose Calculation, preserves all default target spots dosage field separately simultaneously and distributes.
Because it is an iterative process of progressively adding default target spot that target spot is arranged automatically, preserving the dosage field distribution separately of all default target spots is in next iteration, finished Rapid Dose Calculation during for last iteration, and do not change the target spot of any parameter in the next iterative process, do not need to recomputate once more the speed of Rapid Dose Calculation in the time of so just can improving next iteration.
Step 218: upgrade target body 3D voxel model.
With the carrying out that target is arranged, will have increasing voxel in the target body 3D voxel model and obtain dosage.The purpose of this step is to reject from master pattern greater than the voxel of prescribed dose obtaining dose value in the target body 3D voxel model.The part of rejecting represents that this part voxel has obtained enough dosage, and next step iteration will no longer be considered this part voxel.
The flow process of upgrading target body 3D voxel model is: traversal 3D voxel model, if the dose value that certain voxel obtains, then is designated it 0 (the expression target body is outer) more than or equal to dosage such as prescriptions, otherwise it is designated 1 (in the expression target body).As shown in Figure 9, the 2D figure that it illustrates renewal schemes medium and small bullet and is default target position, and Pd represents prescribed dose, is generally 50% isodose.Color burn partly is the target body border.Being designated 0 region representation among the figure is outside the target body, and being designated 1 region representation is in the target body.
Step 220: upgrade target body 3D depth indexing model;
After upgrading target body 3D voxel model, need recomputate target body 3D depth indexing model.After Figure 10 is illustrated in above-mentioned renewal target body 3D voxel model, recomputate the synoptic diagram of the target body 3D depth indexing model that obtains, scheme medium and small bullet and be default target position, Pd represents prescribed dose, is generally 50% isodose.Color burn partly is the target body border.
Step 222: target spot is arranged iteration automatically;
Turn back to step 214, less than default minimum depth value, perhaps iterations is arranged maximum iteration time N automatically greater than target spot up to the depth capacity index of current target body 3D model
t
Can export the result of target spot step at last.
Figure 11 illustrates the structural representation of the embodiment of treatment planning systems according to the present invention, be used for radiocurable dosage planning, it comprises target spot layout module, be used for arranging target spot automatically and export target spot layout result that according to geometric features such as target body profiles target spot arranges that module comprises target body voxel cell, target body depth indexing unit, parameter set unit, cloth target unit, Rapid Dose Calculation unit and iteration unit;
The target body voxel cell is used for making up the target body voxel model according to patient's target body outline data, and the target body voxel model adopts two value defineds, and two value defineds identify respectively in the outer and target body of target body;
Target body depth indexing unit is used for making up target body depth indexing model according to the target body voxel model, and target body depth indexing model comprises the depth information of voxel in the target body;
Parameter set unit is used to select to carry out the parameter that target spot is arranged, parameter comprises prescribed dose, collimating apparatus specification, default iterations and minimum target body depth indexing;
Cloth target unit is used for selecting depth capacity index value zone at target body depth indexing model, and collimating apparatus or the collimator arrangement of selecting the isodose surface width to be fit in the collimating apparatus specification of selecting are carried out the target spot layout;
The Rapid Dose Calculation unit is used for carrying out Rapid Dose Calculation according to the target spot layout;
The target body voxel cell also is used for upgrading the back in the Rapid Dose Calculation result and according to the Rapid Dose Calculation result described target body voxel model is upgraded, the acquisition dose value is set to outside the target body more than or equal to the voxel of prescribed dose, and dose value is set in the target body less than the voxel of prescribed dose;
Iteration unit is used for after the target body voxel cell is upgraded the target body voxel model, call target body depth indexing unit, cloth target unit, Rapid Dose Calculation unit successively, the depth capacity index value in described target body depth indexing model less than the first default index value or iterations greater than default iterations.
A kind of embodiment, wherein target body depth indexing unit also is used for: duplicate the target body voxel model, form initial target body depth indexing model; With the voxel value in the target body depth indexing model be 1 and adjacent voxels at least one voxel value be 0 be set to 1, all the other are set to 0; In target body depth indexing model, iteratively in the target body voxel model voxel value be 1 and corresponding depth indexing's model in voxel value be that the voxel value of 0 voxel is set to: adjacent minimum non-zero voxel value+1; If adjacent all voxel values are 0, then be set to 0, till voxel value is 1 voxel value non-0 in all corresponding described target body voxel models in target body depth indexing model.
Wherein maximum index value is a voxel value maximum in the target body depth indexing model.
A kind of embodiment, wherein cloth target unit also is used for: the voxel of selecting to have maximum voxel value at target body depth indexing model; The voxel that calculating has a maximum voxel value is the minimum distance of 1 voxel to voxel value; Arrange target spot having on the voxel of maximum voxel value, the collimating apparatus of target spot is default isodose surface width and the immediate collimating apparatus of described minimum distance in the collimating apparatus specification of selecting.
A kind of embodiment also further comprises etc. being used to make up dose modals such as collimating apparatus in the dose modal unit, and these dose modals comprise that each collimating apparatus presets the value of isodose surface on coordinate axis; Cloth target unit also is used for selecting depth capacity index value zone at target body depth indexing model, and the collimating apparatus of selecting default isodose surface width to be fit in waiting dose modal is carried out target spot and arranged.
A kind of embodiment, its medium dose modal comprise that also collimator arrangement presets the value of isodose surface on coordinate axis; Cloth target unit also is used for: select depth capacity index value zone at described target body depth indexing model, the collimator arrangement of selecting default isodose surface width to be fit in waiting dose modal is carried out target spot and is arranged.
Above content be in conjunction with concrete embodiment to further describing that the present invention did, can not assert that concrete enforcement of the present invention is confined to these explanations.For the general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, can also make some simple deduction or replace, all should be considered as belonging to protection scope of the present invention.
Claims (10)
1. a treatment plan point of impact on target method for arranging comprises that treatment is preceding in treatment plan, treats the process that target spot is arranged according to the focus in the patient body on target body, it is characterized in that described process comprises:
Steps A: select to carry out the parameter that target spot is arranged, described parameter comprises prescribed dose, collimating apparatus specification, default iterations and minimum target body depth indexing;
Step B: make up the target body voxel model according to patient's target body outline data, described target body voxel model voxel value adopts two value defineds, and described two value defineds identify respectively in the outer and target body of target body;
Step C: make up target body depth indexing model according to described target body voxel model, described depth indexing's model comprises the depth information of voxel in the target body;
Step D: select depth capacity index value zone in described target body depth indexing model, collimating apparatus or the collimator arrangement of selecting default isodose surface width to be fit in the collimating apparatus specification of described selection are carried out the target spot layout;
Step e: carry out Rapid Dose Calculation according to described target spot layout;
Step F: according to the Rapid Dose Calculation result described target body voxel model is upgraded, the acquisition dose value is set to outside the target body more than or equal to the voxel of described prescribed dose, and dose value is set in the target body less than the voxel of prescribed dose;
Step G: repeating step C to the depth capacity index value of step F in target body depth indexing model less than the first default index value or iterations greater than default iterations;
Step H: the output target spot is arranged the result.
2. the method for claim 1 is characterized in that, the two-value among the wherein said step B is defined as the outer voxel value of target body and is set to 0, and the voxel value in the target body is set to 1;
Wherein said step C comprises:
Step C1: duplicate described target body voxel model, form target body depth indexing model;
Step C2: with the voxel value in the described target body depth indexing model be 1 and adjacent voxels at least one voxel value be 0 be set to 1, all the other are set to 0;
Step C3: in described target body depth indexing model, in the described target body voxel model voxel value be 1 and corresponding depth indexing's model in voxel value be that the voxel value of 0 voxel is set to: adjacent minimum non-zero voxel value+1; If adjacent all voxel values are 0, then be set to 0;
Step C4: repeating step C3, till voxel value is 1 voxel value non-0 in all corresponding described target body voxel models in described target body depth indexing model.
The maximum index value of wherein said step D is a voxel value maximum in the described target body depth indexing model.
3. method as claimed in claim 2 is characterized in that, wherein said step D comprises:
Step D1: the voxel of in described target body depth indexing model, selecting to have maximum voxel value;
Step D2: the minimum distance that calculates described voxel and be 1 voxel to voxel value with maximum voxel value;
Step D3: arrange target spot on described voxel with maximum voxel value, the collimating apparatus of described target spot is default isodose surface width and the immediate collimating apparatus of described minimum distance in the collimating apparatus specification of described selection.
4. the method for claim 1 is characterized in that, also comprises before the wherein said step D:
Make up dose modals such as collimating apparatus, the described dose modal that waits comprises that each collimating apparatus presets the value of isodose surface on coordinate axis;
Wherein said step D comprises:
The target spot layout is carried out in the described collimating apparatus of selecting default isodose surface width to be fit in the dose modal that waits in selection depth capacity index value zone in described target body depth indexing model.
5. method as claimed in claim 4 is characterized in that, and the is wherein said dose modal of Denging comprises that also collimator arrangement presets the value of isodose surface on coordinate axis;
Wherein said step D also comprises:
The target spot layout is carried out in the described collimator arrangement of selecting default isodose surface width to be fit in the dose modal that waits in selection depth capacity index value zone in described target body depth indexing model.
6. treatment planning systems, be used for patient is carried out dosage planning before the radiation therapy, it is characterized in that, comprise target spot layout module, be used on target body, arranging target spot according to the target body profile information and export target spot layout result that in treatment plan described target spot arranges that module comprises target body voxel cell, target body depth indexing unit, parameter set unit, cloth target unit, Rapid Dose Calculation unit and iteration unit;
Described target body voxel cell is used for making up the target body voxel model according to patient's target body outline data, and described target body voxel model adopts two value defineds, and described two value defineds identify respectively in the outer and target body of target body;
Described target body depth indexing unit is used for making up target body depth indexing model according to described target body voxel model, and described depth indexing's model comprises the depth information of voxel in the target body;
Described parameter set unit is used to select to carry out the parameter that target spot is arranged, described parameter comprises prescribed dose, collimating apparatus specification, default iterations and the minimum target body degree of depth;
Described cloth target unit is used for selecting depth capacity index value zone at described target body depth indexing model, and collimating apparatus or the collimator arrangement of selecting the isodose surface width to be fit in the collimating apparatus specification of described selection are carried out the target spot layout;
Described Rapid Dose Calculation unit is used for carrying out Rapid Dose Calculation according to the target spot layout;
Described target body voxel cell also is used for upgrading the back in the Rapid Dose Calculation result and according to the Rapid Dose Calculation result described target body voxel model is upgraded, the acquisition dose value is set to outside the target body more than or equal to the voxel of prescribed dose, and dose value is set in the target body less than the voxel of prescribed dose;
Described iteration unit is used for after the target body voxel cell is upgraded described target body voxel model, call described target body depth indexing unit, cloth target unit, Rapid Dose Calculation unit successively, the depth capacity index value in described target body depth indexing model less than the first default index value or iterations greater than default iterations.
7. treatment planning systems as claimed in claim 6 is characterized in that, wherein said target body depth indexing unit also is used for:
Duplicate described target body voxel model, form target body depth indexing model; With the voxel value in the described target body depth indexing model be 1 and adjacent voxels at least one voxel value be 0 be set to 1, all the other are set to 0; In described target body depth indexing model, in the described iteratively target body voxel model voxel value be 1 and corresponding depth indexing's model in voxel value be that the voxel value of 0 voxel is set to: adjacent minimum non-zero voxel value+1; If adjacent all voxel values are 0, then be set to 0, till voxel value is 1 voxel value non-0 in all corresponding described target body voxel models in described target body depth indexing model;
Wherein said maximum index value is a voxel value maximum in the described target body depth indexing model.
8. treatment planning systems as claimed in claim 7 is characterized in that, wherein said cloth target unit also is used for: the voxel of selecting to have maximum voxel value at described target body depth indexing model; Calculate described voxel and be the minimum distance of 1 voxel to voxel value with maximum voxel value; Arrange target spot on described voxel with maximum voxel value, the collimating apparatus of described target spot is default isodose surface width and the immediate collimating apparatus of described minimum distance in the collimating apparatus specification of described selection.
9. treatment planning systems as claimed in claim 6 is characterized in that, also comprises etc. being used to make up dose modals such as collimating apparatus in the dose modal unit, and the described dose modal that waits comprises that each collimating apparatus presets the value of isodose surface on coordinate axis; Described cloth target unit also is used for carrying out the target spot layout in described target body depth indexing model selection depth capacity index value zone in the described collimating apparatus of selecting default isodose surface width to be fit in the dose modal that waits.
10. treatment planning systems as claimed in claim 9 is characterized in that, and the is wherein said dose modal of Denging comprises that also collimator arrangement presets the value of isodose surface on coordinate axis;
Described cloth target unit also is used for:
The target spot layout is carried out in the described collimator arrangement of selecting default isodose surface width to be fit in the dose modal that waits in selection depth capacity index value zone in described target body depth indexing model.
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| CN104645500A (en) * | 2015-02-12 | 2015-05-27 | 上海联影医疗科技有限公司 | Method and system for optimizing intensity modulated radiation therapy |
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Application publication date: 20110518 |