CN102043909A - Target spot arrangement optimizing method for use in treatment planning and treatment planning system - Google Patents
Target spot arrangement optimizing method for use in treatment planning and treatment planning system Download PDFInfo
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Abstract
The invention discloses a target sport arrangement optimizing method for use in treatment planning, which comprises the process of arranging treatment target spots on a target body according to foci in patients in the treatment planning before treatment. The process comprises the following steps of: setting target sport optimizing parameters including formula dosage, the specifications of a collimator and the threshold value of the dosage coverage rate of target body; constructing a voxel model of the target body according to outline data of the target body; arranging the target spots according to the formula dosage and the specifications of the collimator; calculating the dosage according to the arrangement of the target spots; adjusting the positions of the target spots according to the result of the dosage calculation and the dosage coverage rate of target body and updating the result of the dosage calculation; and outputting the result of the arrangement of the target spots. The invention also discloses a treatment planning system. In the method, the positions of the target spots are adjusted by adjusting dosage coverage rate of target body according to the result of the dosage calculation, so the optimizing efficiency is improved, the dosage conformality of the arrangement of the target spots is increased, the local control on target body tumors is enhanced, the injury to peripheral healthy tissues is reduced simultaneously, and the treatment effect is improved.
Description
Technical field
The present invention relates to radiocurable dosage planning, relate in particular to a kind of treatment plan point of impact on target optimizing method for disposing and treatment planning systems.
Background technology
Stereotactic radiotherapy operation or stereotactic radiotherapy are two kinds of common in radiation therapy radiation therapy technologies, and common equipment is based on the gamma knife of cobalt-60 radioactive source and based on the X cutter of electron accelerator.The former usually adopts a plurality of cobalts-60 radioactive source to focus on the mode of irradiation, makes target body accept the uniform irradiation of high dose and surrounding health tissue's amount of being subjected to is very low to reach control or to eradicate the purpose of pathology.Utilize gamma knife treatment equipment to implement to make an acceptable radiotherapy treatment planning usually before the radiation therapy.When formulating treatment plan, doctor and physics teacher need be according to the volume and the shapes of target body, determine the target spot number, adjust the position of each target spot, the collimating apparatus size of each target spot correspondence and the parameters such as relative weighting of each target spot, to obtain the treatment plan of the suitable shape of an overall situation.Because the parameter that relates to is a lot, especially when the big and out-of-shape of volume of target body, when perhaps the contiguous unsoundness of target body was organized, this was a very time-consuming process, and experience and the technical ability to the planned personnel requires very high simultaneously.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, provide a kind of and can improve the target spot optimizing method for disposing of optimizing efficient.
Another object of the present invention is to provide a kind of treatment planning systems based on said method.
For achieving the above object, the present invention has adopted following technical scheme:
A kind of treatment plan point of impact on target optimizing method for disposing comprises that treatment is preceding in treatment plan, treats the process that target spot is arranged according to the focus in the patient body on target body, and described process comprises:
Steps A: the target spot parameters optimization is set, and described parameter comprises: prescribed dose, collimating apparatus specification, target body dosage coverage rate threshold value;
Step B: make up the target body voxel model according to the target body outline data;
Step C: carry out the target spot layout according to prescribed dose and collimating apparatus specification;
Step D: carry out Rapid Dose Calculation according to described target spot layout;
Step e: result and target body dosage coverage rate according to described Rapid Dose Calculation are adjusted target position and are upgraded the Rapid Dose Calculation result;
Step G: the output target spot is arranged the result.
Wherein said step e comprises:
Step e 1: the subregion that described target body voxel model is divided into preset number;
Step e 2: calculate in the described subregion ratio less than total boundary voxel number in the boundary voxel number of prescribed dose and the described subregion;
Step e 3: search has the subregion of maximum described ratio, and will upgrade the Rapid Dose Calculation result apart from the nearest target spot of described subregion with maximum described ratio towards near described direction adjustment with subregion of maximum described ratio;
Step e 4: repeating step E2 to E3 reaches described target body dosage coverage rate threshold value or iterations greater than first iterations until target body dosage coverage rate.
Wherein said step e 3 comprises: search has the subregion of maximum described ratio, structure points to first vector that described distance has the nearest target spot of the subregion of maximum described ratio by the geometric center less than the boundary voxel of described prescribed dose of described subregion with maximum described ratio, with target spot along the opposite direction adjustment of described first direction vector, adjust step-length and be the merchant of distance and described first iterations between the nearest target spot of subregion that described subregion with maximum described ratio has maximum described ratio less than geometric center and the described distance of the boundary voxel of described prescribed dose, renewal Rapid Dose Calculation result.
Also comprise between wherein said step D and the step e:
Step F: result and target body dosage coverage rate according to described Rapid Dose Calculation are adjusted the target spot weight and are upgraded the Rapid Dose Calculation result.
Wherein said step F comprises:
Step F 1: search in the described target body voxel model boundary voxel greater than the first area of described prescribed dose with less than the second area of described prescribed dose;
Step F 2: the weight of the target spot of approaching described first area reduces by first increment, and the weight of the target spot of approaching described second area is increased by second increment;
Step F 3: repeating step F1 to F2 reaches described target body coverage rate threshold value or reaches the secondary iteration number of times up to target body dosage coverage rate.
A kind of treatment planning systems, be used for the dosage planning before patient carries out radiation therapy, comprise target spot layout optimization module, be used for optimizing target spot in treatment plan on target body and arrange and export target spot layout result, described target spot layout optimization module comprises target body voxel cell, parameter set unit, cloth target unit, Rapid Dose Calculation unit, target position adjustment unit;
Described target body voxel cell is used for making up the target body voxel model according to the target body outline data;
Described parameter set unit is used to be provided with the target spot parameters optimization, and described parameter comprises: prescribed dose, collimating apparatus specification, target body dosage coverage rate threshold value;
Described cloth target unit is used for carrying out the target spot layout according to prescribed dose and collimating apparatus specification;
Described Rapid Dose Calculation unit is used for carrying out Rapid Dose Calculation according to the target spot layout;
Described target position adjustment unit is used for adjusting target position and upgrading the Rapid Dose Calculation result according to the result of described Rapid Dose Calculation and target body dosage coverage rate.
Wherein said target position adjustment unit comprises computing unit, first adjustment unit and first iteration unit, described computing unit is used for: described target body voxel model is divided into the subregion of preset number, calculates in the described subregion less than border total number of voxels purpose ratio in the boundary voxel number of prescribed dose and the described subregion; Described first adjustment unit is used to search for the subregion with maximum described ratio, and will upgrade the Rapid Dose Calculation result apart from the nearest target spot of described subregion with maximum described ratio towards near described direction adjustment with subregion of maximum described ratio; Described first iteration unit is used for iteration and calls described first adjustment unit, reaches described target body dosage coverage rate threshold value or iterations greater than first iterations until target body dosage coverage rate.
Wherein said first adjustment unit also is used to search for the subregion with maximum described ratio, structure points to first vector that described distance has the nearest target spot of the subregion of maximum described ratio by the described geometric center less than described prescribed dose boundary voxel with subregion of maximum described ratio, with target spot along the opposite direction adjustment of described first direction vector, adjust step-length and be the merchant of distance and described first iterations between the nearest target spot of subregion that described geometric center and described distance less than described prescribed dose boundary voxel with subregion of maximum described ratio have maximum described ratio, renewal Rapid Dose Calculation result.
Described target spot layout optimization module also comprises the target spot weight adjustment unit, is used for adjusting the target spot weight and upgrading the Rapid Dose Calculation result according to the result and the target body dosage coverage rate of described Rapid Dose Calculation.
Wherein said target spot weight adjustment unit comprises second adjustment unit and secondary iteration unit, described second adjustment unit is used for searching for described target body voxel model boundary voxel greater than the first area of described prescribed dose with less than the second area of described prescribed dose, the weight of the target spot of approaching described first area is reduced by first increment, the weight of the target spot of approaching described second area is increased by second increment; Described secondary iteration unit is used for iteration and calls described second adjustment unit, reaches described target body coverage rate threshold value or reaches the secondary iteration number of times up to target body dosage coverage rate.
Owing to adopted above technical scheme, the beneficial effect that the present invention is possessed is:
(1) the present invention has added Rapid Dose Calculation in the target spot placement process, and pass through target body dosage coverage rate according to the Rapid Dose Calculation result and adjust target position, improved optimizing efficiency, increased the dosage conformal degree that target spot is arranged, increased part control to the target body tumour, reduce damage simultaneously, improve result of treatment peripheral health tissues;
(2) the present invention takes the target area partitioned method, obtains the direction that target spot is adjusted at subregion, makes that the adjustment of target position is more efficient, reduces the time consumption of treatment plan;
(3) the present invention adjusts the target spot weight according to the Rapid Dose Calculation result by target body dosage coverage rate, has further improved optimization efficient, has further increased the dosage conformal degree that target spot is arranged.
Description of drawings
Fig. 1 illustrates the process flow diagram of the embodiment of treatment plan point of impact on target optimizing method for disposing according to the present invention;
Fig. 2 illustrates the process flow diagram of another embodiment of treatment plan target spot optimizing method for disposing according to the present invention;
Fig. 3 illustrates the synoptic diagram according to the target body profile interpolation of another embodiment of the inventive method;
Fig. 4 illustrates the synoptic diagram according to the target body voxelization of another embodiment of the inventive method;
Fig. 5 illustrates the synoptic diagram according to the 3D area dividing of another embodiment of the inventive method;
Fig. 6 illustrates the structural representation of the embodiment of treatment planning systems according to the present invention.
Embodiment
In the treatment plan, after the target body definition, need arrange the target spot of treatment usefulness on target body, the information of target spot comprises the collimating apparatus specification of target position, target spot and the segmental arc of target spot etc.In the process of arranging target spot, need to consider that the suitable shape to target body covers, just allow dose distribution consistent as far as possible, so just radiological dose as much as possible can be projected on the target body, and few as far as possible dosage is projected surrounding health tissue and jeopardizes on the organ with the shape of target body.Jeopardize the organ that organ mainly is meant needs special protection, for head, mainly comprise eyes, brain stem etc., comprise spinal cord etc. for body.
In conjunction with the accompanying drawings the present invention is described in further detail below by embodiment.
Fig. 1 illustrates the process flow diagram of the embodiment of treatment plan point of impact on target optimizing method for disposing according to the present invention, comprising:
Step 102: the target spot parameters optimization is set, and this parameter comprises: prescribed dose, collimating apparatus specification, target body dosage coverage rate threshold value;
Step 104: make up the target body voxel model according to the target body outline data;
Step 106: carry out the target spot layout according to prescribed dose and collimating apparatus specification;
Step 108: carry out Rapid Dose Calculation according to the target spot layout;
Step 110: result and target body dosage coverage rate according to Rapid Dose Calculation are adjusted target position and are upgraded the Rapid Dose Calculation result;
Step 112: the output target spot is arranged the result.
A kind of embodiment, wherein step 108 comprises:
Step 1082: the target body voxel model is divided into the subregion of preset number, for example 8;
Step 1084: calculate in all subregion less than border total number of voxels purpose ratio in the boundary voxel number of prescribed dose and the subregion;
Step 1086: search has the subregion of maximum ratio, and will upgrade the Rapid Dose Calculation result apart from the nearest target spot of the subregion with maximum ratio towards near the direction adjustment with subregion of maximum ratio;
Step 1088: repeating step 1084 to 1086 reaches target body dosage coverage rate threshold value or iterations greater than first iterations until target body dosage coverage rate.
A kind of embodiment, wherein said step 1086 comprises: search has the subregion of maximum ratio, structure is pointed to first vector of the target spot nearest apart from the subregion with maximum ratio less than the geometric center of described prescribed dose boundary voxel by the subregion with maximum ratio, with target spot along the opposite direction adjustment of first direction vector, adjusting step-length is to have the subregion of maximum described ratio less than the geometric center of described prescribed dose boundary voxel and apart from the merchant of distance between the nearest target spot of the subregion with maximum ratio with first iterations, upgrades the Rapid Dose Calculation result.
A kind of embodiment wherein also comprises between step 108 and the step 112:
Step 111: result and target body dosage coverage rate according to Rapid Dose Calculation are adjusted the target spot weight and are upgraded the Rapid Dose Calculation result.
A kind of embodiment, wherein step 111 comprises:
Step 1112: in the search target body voxel model boundary voxel greater than the first area of prescribed dose with less than the second area of prescribed dose;
Step 1114: will be reduce by first increment, the weight of the target spot of approaching described second area is increased by second increment near the weight of the target spot of first area;
Step 1116: repeating step 1112 to 1114 reaches target body dosage coverage rate threshold value or reaches the secondary iteration number of times up to the target body coverage rate.
First iterations and secondary iteration number of times can be respectively certain default value.
It should be appreciated by those skilled in the art that above-mentioned steps is exemplary, its label does not constitute the restriction to its order, and for example step 111 just can be before step 110.
Fig. 2 illustrates the process flow diagram of another embodiment of treatment plan point of impact on target optimizing method for disposing according to the present invention, comprising:
Step 202: input patient positioning image sequence, delineate the outline of patient's body surface, target body, tissue of interest etc.;
Step 204: target spot layout optimization parameter is set;
Prescribed dose line P
d: generally select 50% isodose;
Target body coverage rate (Coverage) PTV
c: for prescribed dose envelope target body volume accounts for the number percent of target body cumulative volume, be typically chosen in 95%;
Target position is adjusted maximum iteration time, i.e. first iterations: N
P
The target spot weight is adjusted maximum iteration time, i.e. secondary iteration number of times: N
w
Step 206: structure target body 3D voxel model;
According to the 2D target body outline that the user delineates on the positioning sequence image, structure target body 3D voxel model is as follows:
A: interpolation target body outline;
Usually during location scanning, the bed thickness of employing or interlamellar spacing are more a lot of greatly than the Pixel Dimensions of positioning image, in order to construct the 3D voxel model of target body, need carry out interpolation to the target body outline, as shown in Figure 3, and S
nAnd S
N+1Be two adjacent positioning images, irregular figure is the target body outline of delineating, S
iBe S
nAnd S
N+1Between certain new images and the new target body profile thereof that obtain by interpolation.
B: by voxelization structure target body 3D voxel model;
After the target body outline carried out interpolation, the voxelization of target body profile is promptly obtained the 3D voxel model of target body, as shown in Figure 4, wherein P represents voxel.Target body 3D voxel model needs sufficiently high resolution to obtain a good result to guarantee that follow-up automatic target spot is arranged usually.A kind of selectable resolution is to adopt the resolution of patient's positioning image, and this resolution is generally 0.5mm-1mm.
Step 208: select to be used for the collimating apparatus specification that target spot is arranged.
Can be according to the consideration of actual target body shape, size or clinical treatment aspect, select to adopt the collimating apparatus of different size to carry out automatic target spot when arranging.For example:, can select the collimating apparatus of F0.8cm and two specifications of F1.5cm or select the collimating apparatus of F0.8cm, F1.5cm and three specifications of F2.5cm to carry out automatic target spot layout for certain target body.
Step 210: arrange target spot.
Target spot is arranged and can be adopted manual the layout or automatic target spot layout, target spot is arranged on certain zone of target body.
Step 212: Rapid Dose Calculation.
Target spot according to determining comprises information such as position, collimating apparatus specification, utilizes the Rapid Dose Calculation engine to carry out Rapid Dose Calculation, preserves all default target spots dosage field separately simultaneously and distributes.
Step 214: target position adjustment.
After target spot was arranged and finished, number, position, corresponding collimating apparatus size and the weight of default target spot had just been decided basically.This step is on this basis, and field distribution is finely tuned the target position of being arranged according to actual dose.Concrete grammar is as follows:
1) is benchmark with default target position or with the default geometric center that makes up target spot, target body is divided into several zones, as shown in Figure 5;
2) calculate in the target body 3D boundary voxel region-by-region, and dose value accounts for the ratio R of target body 3D boundary voxel sum in this regional extent less than the frontier point number of certain preset dose value (being preset as the prescribed dose value usually)
i, as shown in the formula:
R
i＝N
i1/N
i0
In the formula:
I: the number of regions that the expression target body is divided is i=8 in this example;
N
I1: represent in i the zone that dose value is less than the voxel number of preset dose value on the target body 3D border;
N
I0: represent in i the zone voxel total number on the target body 3D border;
Ri is big more, illustrates that this target body 3D border, zone has been subjected to the insufficient dose irradiation, and the volume of prescribed dose envelope is too small.
3) calculate in the target body 3D boundary voxel region-by-region, the geometric center position P of insufficient dose (that is: dose value is less than the voxel of certain preset dose value) part voxel
Wi(x
Wi, y
Wi, z
Wi).
4) according to each region R that calculates
iValue is carried out the adjustment of current preset target position: the R of at first search maximum
iValue promptly obtains the maximum zone of target body insufficient dose irradiation, such as the 3rd zone.Then search in this zone, apart from insufficient dose voxel geometric center of gravity position P
W3(x
W3, y
W3, z
W3) nearest target spot F, then with the position of this target spot F along pointing to P
W3(x
W3, y
W3, z
W3) direction move.Mobile increment is target spot F and P
W3(x
W3, y
W3, z
W3) distance between two points is divided by the current iteration number of times.
5) carry out Rapid Dose Calculation, and assessment target body coverage rate, up to the target body coverage rate greater than default target body coverage rate PTV
cPerhaps iterations is greater than default target position fine setting maximum iteration time N
p
Step 216: the target spot weight is adjusted.
Calculate in the target body 3D boundary voxel region-by-region, overtreatment voxel zone and insufficient dose voxel zone; Search for the subregion of these region adjacents, select the default target spot of contiguous these subregions, adjust the weight of these target spots, carry out Rapid Dose Calculation and assess the target body coverage rate, up to the target body coverage rate greater than default target body coverage rate PTV
cPerhaps iterations is adjusted maximum iteration time N greater than default target spot weight
w
Need to adjust the system of selection of weight target spot: for the overtreatment zone, can these zones of chosen distance in a nearest target spot of maximum overtreatment point; For the insufficient dose zone, can these zones of chosen distance in a nearest target spot of minimum dose point.Another kind method is default scope R
z, for the overtreatment zone, can select and these zones between the maximum overtreatment point distance less than R
zThose target spots; For the insufficient dose zone, can select and these zones between the minimum insufficient dose point distance less than R
zThose target spots.
The method of adjustment of target spot weight: the target spot weight is divided into some grades, adopts the weight of mode right to choose readjust target spot from these alternative weights of selecting at random.For example: target spot weight scope is 1-100, can in advance it be divided into 10 grades, is respectively 10,20,30,40,50,60,70,80,90,100.Therefrom select a weight then at random, as be chosen as the 5th grade, weight is 50, replaces the original weight of target spot with this weight.Another kind method is that near the target spot for the overtreatment zone of selecting reduces by a weight increment Delta w, one by one as a weight grade Δ w=10 on the basis of its original weight; Near for the insufficient dose zone of selecting target spot increases a weight increment Delta w, one by one as a weight grade Δ w=10 on the basis of its original weight.
Step 218: the output target spot is arranged the result.
Fig. 6 illustrates the structural representation of the embodiment of treatment planning systems according to the present invention, be used for radiocurable dosage planning, comprise target spot layout optimization module, be used to optimize target spot and arrange and export target spot layout result, this target spot layout optimization module comprises target body voxel cell, parameter set unit, cloth target unit, Rapid Dose Calculation unit, target position adjustment unit;
The target body voxel cell is used for making up the target body voxel model according to the target body outline data;
Parameter set unit is used to be provided with the target spot parameters optimization, and this parameter comprises: prescribed dose, collimating apparatus specification, target body dosage coverage rate threshold value;
Cloth target unit is used for carrying out the target spot layout according to prescribed dose and collimating apparatus specification;
The Rapid Dose Calculation unit is used for carrying out Rapid Dose Calculation according to the target spot layout;
The target position adjustment unit is used for adjusting target position and upgrading the Rapid Dose Calculation result according to the result of Rapid Dose Calculation and target body dosage coverage rate.
A kind of embodiment, wherein the target position adjustment unit comprises computing unit, first adjustment unit and first iteration unit, computing unit is used for: the target body voxel model is divided into the subregion of preset number, calculates in the subregion less than border total number of voxels purpose ratio in the boundary voxel number of prescribed dose and the subregion; First adjustment unit is used to search for the subregion with maximum ratio, and will upgrade the Rapid Dose Calculation result apart from the nearest target spot of the subregion with maximum ratio towards near the direction adjustment with subregion of maximum ratio; First iteration unit is used for iteration and calls first adjustment unit, reaches target body dosage coverage rate threshold value or iterations greater than first iterations until target body dosage coverage rate.
A kind of embodiment, wherein first adjustment unit also is used to search for the subregion with maximum ratio, structure is pointed to first vector of the target spot nearest apart from the subregion with maximum ratio by the geometric center less than the prescribed dose boundary voxel of the subregion with maximum ratio, with target spot along the opposite direction adjustment of first direction vector, adjust step-length and be the merchant who has distance and first iterations between the nearest target spot of the subregion of maximum ratio less than the geometric center of prescribed dose boundary voxel and distance of subregion, renewal Rapid Dose Calculation result with maximum ratio.
A kind of embodiment, target spot layout optimization module also comprises the target spot weight adjustment unit, is used for adjusting the target spot weight and upgrading the Rapid Dose Calculation result according to the result and the target body dosage coverage rate of described Rapid Dose Calculation.
A kind of embodiment, its point of impact on target weight adjustment unit comprises second adjustment unit and secondary iteration unit, second adjustment unit is used for searching for target body voxel model boundary voxel greater than the first area of prescribed dose with less than the second area of prescribed dose, weight near the target spot of first area is reduced by first increment, the weight near the target spot of second area is increased by second increment; The secondary iteration unit is used for iteration and calls second adjustment unit, reaches target body coverage rate threshold value or reaches the secondary iteration number of times up to target body dosage coverage rate.
Above content be in conjunction with concrete embodiment to further describing that the present invention did, can not assert that concrete enforcement of the present invention is confined to these explanations.For the general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, can also make some simple deduction or replace, all should be considered as belonging to protection scope of the present invention.
Claims (10)
1. a treatment plan point of impact on target optimizing method for disposing comprises that treatment is preceding in treatment plan, treats the process that target spot is arranged according to the focus in the patient body on target body, it is characterized in that described process comprises:
Steps A: the target spot parameters optimization is set, and described parameter comprises: prescribed dose, collimating apparatus specification, target body dosage coverage rate threshold value;
Step B: make up the target body voxel model according to the target body outline data;
Step C: carry out the target spot layout according to prescribed dose and collimating apparatus specification;
Step D: carry out Rapid Dose Calculation according to described target spot layout;
Step e: result and target body dosage coverage rate according to described Rapid Dose Calculation are adjusted target position and are upgraded the Rapid Dose Calculation result;
Step G: the output target spot is arranged the result.
2. the method for claim 1 is characterized in that, wherein said step e comprises:
Step e 1: the subregion that described target body voxel model is divided into preset number;
Step e 2: calculate in the described subregion ratio less than total boundary voxel number in the boundary voxel number of prescribed dose and the described subregion;
Step e 3: search has the subregion of maximum described ratio, and will upgrade the Rapid Dose Calculation result apart from the nearest target spot of described subregion with maximum described ratio towards near described direction adjustment with subregion of maximum described ratio;
Step e 4: repeating step E2 to E3 reaches described target body dosage coverage rate threshold value or iterations greater than first iterations until target body dosage coverage rate.
3. method as claimed in claim 2 is characterized in that, wherein said step e 3 comprises:
Search has the subregion of maximum described ratio, structure points to first vector that described distance has the nearest target spot of the subregion of maximum described ratio by the geometric center less than the boundary voxel of described prescribed dose of described subregion with maximum described ratio, with target spot along the opposite direction adjustment of described first direction vector, adjust step-length and be the merchant of distance and described first iterations between the nearest target spot of subregion that described subregion with maximum described ratio has maximum described ratio less than geometric center and the described distance of the boundary voxel of described prescribed dose, renewal Rapid Dose Calculation result.
4. the method for claim 1 is characterized in that, also comprises between wherein said step D and the step e:
Step F: result and target body dosage coverage rate according to described Rapid Dose Calculation are adjusted the target spot weight and are upgraded the Rapid Dose Calculation result.
5. method as claimed in claim 4 is characterized in that, wherein said step F comprises:
Step F 1: search in the described target body voxel model boundary voxel greater than the first area of described prescribed dose with less than the second area of described prescribed dose;
Step F 2: the weight of the target spot of approaching described first area reduces by first increment, and the weight of the target spot of approaching described second area is increased by second increment;
Step F 3: repeating step F1 to F2 reaches described target body coverage rate threshold value or reaches the secondary iteration number of times up to target body dosage coverage rate.
6. treatment planning systems, be used for the dosage planning before patient carries out radiation therapy, it is characterized in that, comprise target spot layout optimization module, be used for optimizing target spot in treatment plan on target body and arrange and export target spot layout result, described target spot layout optimization module comprises target body voxel cell, parameter set unit, cloth target unit, Rapid Dose Calculation unit, target position adjustment unit;
Described target body voxel cell is used for making up the target body voxel model according to the target body outline data;
Described parameter set unit is used to be provided with the target spot parameters optimization, and described parameter comprises: prescribed dose, collimating apparatus specification, target body dosage coverage rate threshold value;
Described cloth target unit is used for carrying out the target spot layout according to prescribed dose and collimating apparatus specification;
Described Rapid Dose Calculation unit is used for carrying out Rapid Dose Calculation according to the target spot layout;
Described target position adjustment unit is used for adjusting target position and upgrading the Rapid Dose Calculation result according to the result of described Rapid Dose Calculation and target body dosage coverage rate.
7. treatment planning systems as claimed in claim 6, it is characterized in that, wherein said target position adjustment unit comprises computing unit, first adjustment unit and first iteration unit, described computing unit is used for: described target body voxel model is divided into the subregion of preset number, calculates in the described subregion less than border total number of voxels purpose ratio in the boundary voxel number of prescribed dose and the described subregion; Described first adjustment unit is used to search for the subregion with maximum described ratio, and will upgrade the Rapid Dose Calculation result apart from the nearest target spot of described subregion with maximum described ratio towards near described direction adjustment with subregion of maximum described ratio; Described first iteration unit is used for iteration and calls described first adjustment unit, reaches described target body dosage coverage rate threshold value or iterations greater than first iterations until target body dosage coverage rate.
8. treatment planning systems as claimed in claim 7, it is characterized in that, wherein said first adjustment unit also is used to search for the subregion with maximum described ratio, structure points to first vector that described distance has the nearest target spot of the subregion of maximum described ratio by the described geometric center less than described prescribed dose boundary voxel with subregion of maximum described ratio, with target spot along the opposite direction adjustment of described first direction vector, adjust step-length and be the merchant of distance and described first iterations between the nearest target spot of subregion that described geometric center and described distance less than described prescribed dose boundary voxel with subregion of maximum described ratio have maximum described ratio, renewal Rapid Dose Calculation result.
9. treatment planning systems as claimed in claim 6, it is characterized in that, described target spot layout optimization module also comprises the target spot weight adjustment unit, is used for adjusting the target spot weight and upgrading the Rapid Dose Calculation result according to the result and the target body dosage coverage rate of described Rapid Dose Calculation.
10. treatment planning systems as claimed in claim 9, it is characterized in that, wherein said target spot weight adjustment unit comprises second adjustment unit and secondary iteration unit, described second adjustment unit is used for searching for described target body voxel model boundary voxel greater than the first area of described prescribed dose with less than the second area of described prescribed dose, the weight of the target spot of approaching described first area is reduced by first increment, the weight of the target spot of approaching described second area is increased by second increment; Described secondary iteration unit is used for iteration and calls described second adjustment unit, reaches described target body coverage rate threshold value or reaches the secondary iteration number of times up to target body dosage coverage rate.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104645500A (en) * | 2015-02-12 | 2015-05-27 | 上海联影医疗科技有限公司 | Method and system for optimizing intensity modulated radiation therapy |
| CN105447330A (en) * | 2015-12-30 | 2016-03-30 | 上海联影医疗科技有限公司 | Weight adjustment method and weight adjustment device of intensity-modulated radiation therapy |
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| CN104645500A (en) * | 2015-02-12 | 2015-05-27 | 上海联影医疗科技有限公司 | Method and system for optimizing intensity modulated radiation therapy |
| CN104645500B (en) * | 2015-02-12 | 2018-08-03 | 上海联影医疗科技有限公司 | A kind of intensity modulated radiation therapy optimization system |
| CN105447330A (en) * | 2015-12-30 | 2016-03-30 | 上海联影医疗科技有限公司 | Weight adjustment method and weight adjustment device of intensity-modulated radiation therapy |
| CN105447330B (en) * | 2015-12-30 | 2019-01-08 | 上海联影医疗科技有限公司 | The weight regulating method and device of intensity-modulated radiation therapy |
| CN109069861A (en) * | 2016-03-30 | 2018-12-21 | 瓦里安医疗系统国际股份公司 | Dosage in proton therapy is distributed estimation |
| CN109069861B (en) * | 2016-03-30 | 2021-12-28 | 瓦里安医疗系统国际股份公司 | System for estimating dose from proton therapy plan |
| US11738211B2 (en) | 2016-03-30 | 2023-08-29 | Siemens Healthineers International Ag | Dose-distribution estimation in proton therapy |
| CN109923615A (en) * | 2016-11-07 | 2019-06-21 | 皇家飞利浦有限公司 | Volume modulates the method for optimizing collimator trajectory in radian treatment |
| CN106730411A (en) * | 2016-12-21 | 2017-05-31 | 上海联影医疗科技有限公司 | Radiotherapy treatment planning optimization method and system |
| CN106730411B (en) * | 2016-12-21 | 2019-11-19 | 上海联影医疗科技有限公司 | Radiotherapy treatment planning optimization method and system |
| CN114344737A (en) * | 2022-01-07 | 2022-04-15 | 北京大学第一医院 | Tumor radiotherapy control system and storage medium |
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