CN117695879A - Mixed production process of mixture for treating osteoporosis - Google Patents
Mixed production process of mixture for treating osteoporosis Download PDFInfo
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- CN117695879A CN117695879A CN202410166191.2A CN202410166191A CN117695879A CN 117695879 A CN117695879 A CN 117695879A CN 202410166191 A CN202410166191 A CN 202410166191A CN 117695879 A CN117695879 A CN 117695879A
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 22
- 239000000203 mixture Substances 0.000 title claims abstract description 22
- 208000001132 Osteoporosis Diseases 0.000 title claims abstract description 20
- 239000007788 liquid Substances 0.000 claims abstract description 215
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 95
- 238000002156 mixing Methods 0.000 claims abstract description 79
- 239000011550 stock solution Substances 0.000 claims abstract description 72
- 238000003756 stirring Methods 0.000 claims abstract description 41
- 239000000463 material Substances 0.000 claims abstract description 18
- 238000001914 filtration Methods 0.000 claims abstract description 11
- 238000007599 discharging Methods 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 8
- 239000011259 mixed solution Substances 0.000 claims abstract description 8
- 239000012528 membrane Substances 0.000 claims abstract description 7
- 230000005484 gravity Effects 0.000 claims abstract description 5
- 238000001514 detection method Methods 0.000 claims description 26
- 230000003044 adaptive effect Effects 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 7
- 241000222336 Ganoderma Species 0.000 claims description 5
- 230000008602 contraction Effects 0.000 claims description 5
- 241000221377 Auricularia Species 0.000 claims description 4
- 241000756943 Codonopsis Species 0.000 claims description 4
- 239000009636 Huang Qi Substances 0.000 claims description 4
- 238000010025 steaming Methods 0.000 claims description 4
- 108010019160 Pancreatin Proteins 0.000 claims description 3
- 239000002639 bone cement Substances 0.000 claims description 3
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 235000013372 meat Nutrition 0.000 claims description 3
- 229940055695 pancreatin Drugs 0.000 claims description 3
- 238000002845 discoloration Methods 0.000 claims description 2
- 238000009423 ventilation Methods 0.000 claims 1
- 238000005265 energy consumption Methods 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 239000002699 waste material Substances 0.000 abstract description 4
- 238000004321 preservation Methods 0.000 description 3
- 239000002893 slag Substances 0.000 description 2
- 241000233866 Fungi Species 0.000 description 1
- 240000000038 Ziziphus mauritiana Species 0.000 description 1
- 235000006545 Ziziphus mauritiana Nutrition 0.000 description 1
- 235000008529 Ziziphus vulgaris Nutrition 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 229940107666 astragalus root Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
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Abstract
The invention discloses a mixed production process of a mixture for treating osteoporosis, which comprises the following steps: step one, preparing a stock solution; step two, preparing a mixed material, which comprises the following steps: respectively feeding bone liquid and other stock solutions into different cavities of a preset multi-cavity mixing device, so that the bone liquid and the other stock solutions contact the outer wall of one cavity serving as a mixing cavity; step three, mixing materials, which comprises the following steps: based on the height difference between the bone liquid in the multi-layer cavity mixing device and the liquid level in the mixing cavity and the height difference between other stock solutions and the liquid level in the mixing cavity, the bone liquid and other stock solutions are fed into the mixing cavity in a mode of discharging under the action of gravity and/or actively pressurizing and discharging; stirring the liquid in the mixing cavity by using a stirring mechanism corresponding to the multi-layer cavity mixing device, and controlling the temperature according to the formula in the stirring process; step four, filtering the mixed solution, which comprises the following steps: and filtering the mixed solution obtained by mixing by using an inorganic membrane to obtain a product stock solution. The method has the effect of reducing energy consumption waste in the production process.
Description
Technical Field
The application relates to the technical field of mixed production, in particular to a mixed production process of a mixture for treating osteoporosis.
Background
The related data and clinic prove that the oral liquid prepared by taking bone liquid, dangshen, astragalus root, lucid ganoderma, chinese date and black fungus as raw materials has the effects of tonifying qi and producing blood, nourishing liver and kidney, filling marrow and strengthening bones and the like, is suitable for osteoporosis and other symptoms, and has better market application scenes, and related manufacturers intend to carry out industrial production on the oral liquid.
One of the key steps in the preparation of the oral liquid is mixing of raw liquid, and at present, one mixing mode is as follows: preparing various stock solutions in advance, and then respectively taking materials according to a formula, putting the materials into a mixing device for stirring treatment so as to achieve the aim of mixing; however, because the stock solution is viscous and the bone solution has a coagulation probability, heat preservation and the like are needed before the stock solution is taken, and especially when one stock solution is not used up in one batch and needs to be matched with other stock solutions in the next batch, the energy consumption is increased, and the application provides a new technical scheme.
Disclosure of Invention
In order to reduce energy waste during the production process, the present application provides a hybrid production process for a mixture for treating osteoporosis.
The application provides a mixed production process of a mixture for treating osteoporosis, which adopts the following technical scheme:
a hybrid manufacturing process for a mixture for treating osteoporosis comprising:
step one, preparing a stock solution, which comprises the following steps: bone liquid preparation and other stock solutions preparation;
step two, preparing a mixed material, which comprises the following steps: respectively feeding bone liquid and other stock solutions into different cavities of a preset multi-cavity mixing device, so that the bone liquid and the other stock solutions contact the outer wall of one cavity serving as a mixing cavity;
step three, mixing materials, which comprises the following steps:
based on the height difference between the bone liquid in the multi-layer cavity mixing device and the liquid level in the mixing cavity and the height difference between other stock solutions and the liquid level in the mixing cavity, the bone liquid and other stock solutions are fed into the mixing cavity in a mode of discharging under the action of gravity and/or actively pressurizing and discharging;
stirring the liquid in the mixing cavity by using a stirring mechanism corresponding to the multi-layer cavity mixing device, and controlling the temperature according to the formula in the stirring process;
step four, filtering the mixed solution, which comprises the following steps: and filtering the mixed solution obtained by mixing by using an inorganic membrane to obtain a product stock solution.
Optionally, the multi-layer cavity mixing device includes:
the inner tank body is provided with a cavity body as a mixing cavity;
the outer tank body is arranged around the inner tank body and is divided into a bone liquid cavity and at least one other stock solution cavity;
the stirring mechanism is arranged on the inner tank body and is used for stirring operation;
the liquid level detection module is used for detecting the liquid levels of the mixing cavity, the bone liquid cavity and other stock solution cavities and outputting the liquid levels;
the pressurizing mechanism is used for actively pressurizing the bone liquid cavity and other stock solution cavities;
the wall plate on the inner side of the outer tank body is a side wall of the inner tank body, a first through hole communicated with the bone liquid cavity and a second through hole communicated with other stock liquid cavities are formed in the side wall of the inner tank body, an adaptive electric control valve I is arranged at the first through hole, and an adaptive electric control valve II is arranged at the second through hole; the upper part of the inner tank body is provided with a vent valve, and the lower part of the inner tank body is provided with a discharge valve;
the pressurizing mechanism comprises a balance pipe I, an electric control valve III, an electric cylinder I, a piston plate I, a balance pipe II, an electric control valve IV, an electric cylinder II and a piston plate II;
the piston plate I is matched with the cross section of the bone liquid cavity and is vertically connected with the bone liquid cavity in a sliding manner, the cylinder body of the electric cylinder I is fixed on the outer tank body, the rod end of the electric cylinder I is fixed on the piston plate I, the balance pipe I penetrates through the outer tank body and the piston plate I, the balance pipe I is vertically connected with the outer tank body in a sliding manner, the balance pipe I is fixed with the piston plate I, and the electric control valve III is arranged on the balance pipe I and is close to the upper part of the piston plate I;
the piston plate II is matched with the cross sections of other stock solution cavities and is connected with the other stock solution cavities in a vertical sliding mode, the cylinder body of the electric cylinder II is fixed to the outer tank body, the rod end of the electric cylinder II is fixed to the piston plate II, the balance pipe II penetrates through the outer tank body and the piston plate II, the balance pipe II is connected with the outer tank body in a vertical sliding mode, the balance pipe II is fixed to the piston plate II, and the electric control valve IV is installed on the upper portion of the balance pipe II and close to the piston plate II.
Optionally, the multi-layer cavity mixing device further comprises a controller electrically connected with the liquid level detection module, the stirring mechanism and the pressurizing mechanism;
the liquid level in the bone liquid cavity is called liquid level A, the liquid levels in other stock solution cavities are called liquid level B, and the liquid level in the mixing cavity is called liquid level C;
when the controller receives a mixing instruction, the liquid level A is larger than a preset bone liquid level lower limit threshold value, the liquid level B is larger than other preset stock solution lower limit threshold values, and the liquid level C is an empty liquid level, the controller:
if the liquid level A is greater than the liquid level B, opening the first electric control valve and the third electric control valve, and determining the closing time according to the bone liquid proportion in the preset formula and the variation of the liquid level A;
after the first electric control valve is closed, the second electric control valve is opened, when the difference value between the liquid level B and the liquid level C is smaller than the preset minimum liquid level difference, the fourth electric control valve is closed, and the second electric cylinder is extended until the change amount of the liquid level B is matched with the change amount of the liquid level A;
if the liquid level B is greater than the liquid level A, opening the second electric control valve and the fourth electric control valve, and determining the closing time according to the bone liquid proportion in the preset formula and the variation of the liquid level B;
and after the second electric control valve is closed, the first electric control valve is opened, and when the difference value between the liquid level A and the liquid level C is smaller than the preset minimum liquid level difference, the third electric control valve is closed, and the first electric cylinder stretches until the variation of the liquid level A matches the variation of the liquid level B.
Optionally, when the liquid level C is greater than a preset lower limit threshold of the mixture, the controller controls the stirring mechanism to perform a stirring action.
Optionally, the liquid level detection module comprises a movable detection unit and a floating ball liquid level meter, the floating ball liquid level meter is installed on the inner tank body, the movable detection unit comprises a floater, a ranging sensor and a guide rail, the guide rail is vertically arranged and provided with a guide groove along the length direction, one side of the floater is fixed with a sliding block, and the sliding block is connected with the guide groove in a sliding manner;
the bone liquid cavity and other stock solution cavities are respectively provided with a movable detection unit, the guide rail penetrates through the corresponding first piston plate and the corresponding second piston plate, the distance measuring sensor is located above the floater and used for detecting the distance between the distance measuring sensor and the floater, and the distance measuring sensor is arranged on the corresponding first piston plate and the corresponding second piston plate.
Optionally, the controller obtains the liquid level A and the liquid level B according to the expansion and contraction amount of the first electric cylinder, the expansion and contraction amount of the second electric cylinder and the detection value of each ranging sensor.
Optionally, the bone liquid preparation includes:
taking bones with the matched formula, and removing residual meat, metamorphism, discoloration and non-bone components;
cleaning and draining;
steaming the drained bone;
crushing the steamed bones, and adding water to grind into bone paste;
adding a pre-acid-base reagent, and adjusting the pH value to a specified pH value;
adding pancreatin and stirring;
removing bone residues in the bone liquid after enzymolysis; the method comprises the steps of,
the bone fluid was filtered with an inorganic membrane.
Optionally, the preparation of the other stock solution includes:
taking traditional Chinese medicinal materials with an adaptive formula; wherein the Chinese medicinal materials comprise radix astragali, radix Codonopsis, ganoderma, fructus Jujubae and Auricularia;
adding water in an adaptive proportion I, and decocting for a period of T1;
adding water with an adaptive proportion II, and decocting for a period of T2;
filtering the decoction liquid, and concentrating until the relative density is more than or equal to L; wherein, the first proportion, the second proportion, the time length T1, the time length T2 and the time length L are all preset values in the formula.
In summary, the present application includes at least one of the following beneficial technical effects: stock solutions and other stock solutions for making a mixture for treating osteoporosis are temporarily stored in an area where heat exchange with the mixture is possible, so that, on the one hand, heat from the non-activated liquid can be utilized, such as: heat preservation is carried out to reduce heat loss of the mixing cavity; on the other hand, the heat dissipated by the mixing cavity is utilized and is not dissipated into the environment directly, but is transferred to the non-activated bone liquid and other stock solutions, so that the energy consumption waste in the production process can be reduced.
Drawings
FIG. 1 is a schematic cross-sectional view of a multi-layer cavity mixing device of the present application;
fig. 2 is a schematic control structure of the multi-layer cavity mixing device of the present application.
Reference numerals illustrate: 1. an inner tank; 11. a vent valve; 12. a discharge valve; 13. an electric control valve I; 14. an electric control valve II; 2. an outer can; 3. a stirring mechanism; 31. a stirring motor; 32. a stirring rod; 4. a liquid level detection module; 41. a motion detection unit; 411. a float; 412. a ranging sensor; 413. a guide rail; 42. a floating ball level gauge; 5. a pressurizing mechanism; 51. a balance pipe I; 52. an electric control valve III; 53. an electric cylinder I; 54. a first piston plate; 55. a balance pipe II; 56. an electric control valve IV; 57. an electric cylinder II; 58. a second piston plate; 6. and a controller.
Detailed Description
The present application is described in further detail below in conjunction with figures 1-2.
The embodiment of the application discloses a mixed production process of a mixture for treating osteoporosis.
Referring to fig. 1, the hybrid production process for a mixture for treating osteoporosis includes:
step one, preparing a stock solution, which comprises the following steps: bone liquid preparation and other stock solutions preparation; in this embodiment, the other stock solutions are obtained by decocting several Chinese medicinal materials including radix astragali, radix Codonopsis, ganoderma, fructus Jujubae, and Auricularia;
step two, preparing a mixed material, which comprises the following steps: respectively feeding bone liquid and other stock solutions into different cavities of a preset multi-cavity mixing device, so that the bone liquid and the other stock solutions contact the outer wall of one cavity serving as a mixing cavity;
step three, mixing materials, which comprises the following steps:
based on the height difference between the bone liquid in the multi-layer cavity mixing device and the liquid level in the mixing cavity and the height difference between other stock solutions and the liquid level in the mixing cavity, the bone liquid and other stock solutions are fed into the mixing cavity in a mode of discharging under the action of gravity and/or actively pressurizing and discharging;
stirring the liquid in the mixing cavity by using a stirring mechanism corresponding to the multi-layer cavity mixing device, and controlling the temperature according to the formula (for example, maintaining 50-70 ℃);
step four, filtering the mixed solution, which comprises the following steps: filtering the mixed solution by using an inorganic membrane to obtain a product stock solution, wherein the product stock solution can be prepared into a drink or spray-dried and then tabletted.
From the above, it follows that the stock solutions and other stock solutions of the mixture for the treatment of osteoporosis are temporarily stored in areas where they can be heat exchanged with the mixture, so that on the one hand, the heat of the non-activated liquid can be utilized, such as: heat preservation is carried out to reduce heat loss of the mixing cavity; on the other hand, the heat dissipated by the mixing cavity is utilized and is not dissipated into the environment directly, but is transferred to the non-activated bone liquid and other stock solutions, so that the energy consumption waste in the production process can be reduced.
Referring to fig. 1, the multi-layer cavity mixing device comprises an inner tank 1, an outer tank 2, a stirring mechanism 3, a liquid level detection module 4 and a pressurizing mechanism 5.
The inner tank body 1 is columnar, and the cavity of the inner tank body is used as a mixing cavity; the upper portion of the inner tank 1 is fixed with an external pipeline, a vent valve 11 is arranged on the pipeline, the lower portion of the inner tank 1 is fixed with an external pipeline, and a discharge valve 12 is arranged on the pipeline. Both the vent valve 11 and the discharge valve 12 may be of electrically controlled valve construction to facilitate control and both valves should be opened at least during discharge.
The outer tank 2 is arranged around the inner tank 1 and shares a wall plate with the inner tank 1, namely, the wall plate on the inner side of the outer tank 2 is the side wall of the inner tank 1; the inner cavity of the outer tank body 2 is divided into a bone liquid cavity and at least one other stock liquid cavity. In this embodiment, the inner cavity of the outer tank 2 is divided into two cavities by a plate structure with a parallel longitudinal section, and one is a bone fluid cavity and the other is another stock solution cavity.
The side wall of the inner tank body 1 is provided with a first through hole communicated with the bone liquid cavity and a second through hole communicated with other stock liquid cavities. The first through hole is provided with an adaptive electric control valve I13, and the second through hole is provided with an adaptive electric control valve II 14.
Referring to fig. 1, the booster mechanism 5 includes a balance pipe one 51, an electric control valve three 52, an electric cylinder one 53, a piston plate one 54, a balance pipe two 55, an electric control valve four 56, an electric cylinder two 57, and a piston plate two 58.
The piston plate I54 is matched with the cross section of the bone liquid cavity and is vertically connected with the bone liquid cavity in a sliding manner, the cylinder body of the electric cylinder I53 is fixed on the top of the outer tank body 2, and the rod end is downwards fixed on the piston plate I54; the balance pipe I51 penetrates through the outer tank body 2 and the piston plate I54, the balance pipe I51 is in vertical sliding connection with the outer tank body 2, and the balance pipe I51 is fixed with the piston plate I; the third electric control valve 52 is arranged on the balance pipe I51 and is close to the upper part of the piston plate I54;
the second piston plate 58 is adapted to the cross section of other stock solution cavities and is vertically connected with the other stock solution cavities in a sliding manner, the cylinder body of the second electric cylinder 57 is fixed on the top of the outer tank body 2, and the rod end is fixed on the second piston plate 58; the balance pipe II 55 penetrates through the outer tank body 2 and the piston plate II 58, the balance pipe II 55 is in vertical sliding connection with the outer tank body, and the balance pipe II 55 is fixed with the piston plate II 58; an electrically controlled valve four 56 is mounted to the balance tube two 55 near the upper portion of the piston plate two 58.
Referring to fig. 1, the stirring mechanism 3 includes a stirring motor 31 and a stirring rod 32, the stirring motor 31 is installed at the upper portion of the inner tank 1, the main structure of the stirring rod 32 is located in the inner tank 1, and the upper end of the stirring rod is penetrated upward through the top of the inner tank 1 and is fixed to the stirring motor 31, so that the stirring rod 32 is driven to rotate by the stirring motor 31 to implement the mixing action.
Referring to fig. 1 and 2, the multi-layer cavity mixing device further includes a controller 6 electrically connected to the liquid level detection module 4, the stirring mechanism 3, and the pressurizing mechanism 5, and the controller 6 may be a PLC controller.
In this embodiment, the liquid level in the bone liquid cavity is referred to as liquid level a, the liquid levels in the other stock solution cavities are referred to as liquid level B, and the liquid level in the mixing cavity is referred to as liquid level C.
The controller 6 is arranged to: when receiving a mixing instruction input by a user through a key and a touch pad, the liquid level A is greater than a preset bone liquid level lower limit threshold, the liquid level B is greater than other preset stock solution lower limit thresholds, and the liquid level C is an empty liquid level, and the controller 6:
1) If the liquid level A is greater than the liquid level B, namely the liquid level of bone liquid is higher, opening the first electric control valve 13 and the third electric control valve 52 (namely the bone liquid cavity is communicated with the atmosphere and the bone liquid cavity is communicated with the mixing cavity), and determining the closing time of the two valves according to the ratio of the bone liquid in a preset formula and the variation of the liquid level A; it can be understood that the variation of the liquid level A is the bone liquid dosage;
after the first electric control valve 13 is closed, the second electric control valve 14 is opened (i.e. the other stock solution cavities are communicated with the mixing cavity), when the difference value (obtained by subtracting) between the liquid level B and the liquid level C is smaller than the preset minimum liquid level difference, i.e. the liquid level position in the mixing cavity is higher, the fourth electric control valve 56 is closed (i.e. the other stock solution cavities are not communicated with the atmosphere and are ready for active pressurization to discharge stock solution), and the second electric cylinder 57 is extended until the variation of the liquid level B is matched with the variation of the liquid level B, i.e. the use amounts of bone liquid and other stock solutions are matched.
2) If the liquid level B is greater than the liquid level A, opening the second electric control valve 14 and the fourth electric control valve 56 (namely, other stock solution cavities are communicated with the atmosphere and other stock solution cavities are communicated with the mixing cavity), wherein the closing time of the two valves is determined according to the bone liquid proportion in the preset formula and the variation of the liquid level B;
after the second electric control valve 14 is closed, the first electric control valve 13 is opened, and when the difference between the liquid level A and the liquid level C is smaller than the preset minimum liquid level difference, the third electric control valve is closed (namely, the bone liquid cavity is not communicated with the atmosphere and is ready for active pressurization to discharge bone liquid), the first electric cylinder 53 is stretched until the variation of the liquid level A is matched with the variation of the liquid level B, and the use amount of the bone liquid and other stock solutions is matched.
According to the above arrangement, in the present application:
when the bone liquid and other stock solutions are required to be mixed, firstly, liquid is injected into the mixing cavity by utilizing the gravity of the liquid based on the 'communicating vessel principle'; when other liquid is injected next time, if the liquid level difference is insufficient, the liquid is injected into the mixing cavity in an active pressurizing mode by pushing the electric cylinder, so that on one hand, the raw liquid can be ensured to smoothly enter the mixing cavity; on one hand, the energy consumption for feeding materials into the mixing cavity is lower; in yet another aspect, backflow of the mixed liquor in the mixing chamber is prevented and contamination of the non-activated stock liquor is prevented.
On the basis of the above, the present application further sets the controller 6 to: when the liquid level C is greater than the preset mixing lower limit threshold, that is, when enough liquid exists in the mixing cavity, the controller 6 controls the stirring mechanism 3 to perform stirring action. This setting can improve the use convenience of multilayer cavity compounding device.
Because the piston plate is lifted in the bone liquid cavity and other stock liquid cavities, the liquid level detection mode of the driving floating ball is disturbed when the piston plate is lifted, and the liquid level detection module 4 is improved in one embodiment of the application.
The liquid level detection module 4 comprises a movable detection unit 41 and a floating ball liquid level meter 42; wherein, the floating ball liquid level meter 42 is installed on the inner tank 1 for detecting the liquid level in the inner tank 1; the float gauge 42 is electronically output and outputs to the controller 6.
The activity detection unit 41 includes a float 411, a ranging sensor 412, and a guide rail 413; the bone fluid cavity and the other stock solution cavities are respectively provided with a movement detection unit 41. The guide rail 413 is vertically arranged along the inner wall of the outer tank body 2, a guide groove is formed in the guide rail 413, the floater 411 is a hollow sphere, one side of the floater is fixed with a supporting rod, a sliding block is fixed with the supporting rod, and the sliding block is glidingly connected with the guide groove. The guide rail 413 penetrates the corresponding first and second piston plates 54, 58, and the ranging sensor 412 may be a laser ranging sensor and is mounted to the corresponding first and second piston plates 54, 58; the probe of the ranging sensor 412 faces downward toward the downward float 411.
According to the above arrangement, the controller 6 obtains the liquid level a and the liquid level B from the detection values of the first electric cylinder 53, the second electric cylinder 57, and the respective ranging sensors 412, for example:
the initial position of the first electric cylinder 53 is Z1, and after the action, the position is changed to Z2, and the expansion and contraction amount is Z1-Z2; at this time, if the detection of the ranging sensor 412 on the first piston plate 54 is Z3, the liquid level a=z1-Z2-Z3; the liquid level B is calculated in the same way.
In one embodiment of the present application, bone fluid preparation comprises:
taking bones (such as pig bones) with the matched formula, and removing residual meat, spoiled, discolored and non-bone components;
cleaning and draining;
steaming the drained bone, wherein the steaming time is determined by a worker;
crushing the steamed bones by a bone crusher, adding water, and grinding by a bone grinder to obtain bone paste;
adding a pre-acid-base reagent, and adjusting the pH value to a specified pH value, wherein the pH value can be 7.5;
adding pancreatin and stirring;
removing bone slag in the bone liquid after enzymolysis, wherein the removing mode of the bone slag can be separation by an oscillating screen and a disc type centrifuge so as to obtain the bone liquid; the method comprises the steps of,
the bone fluid was filtered with an inorganic membrane.
In one embodiment of the present application, the preparation of the other stock solution comprises:
taking traditional Chinese medicinal materials with an adaptive formula; wherein the Chinese medicinal materials comprise radix astragali, radix Codonopsis, ganoderma, fructus Jujubae and Auricularia;
adding water in the proper proportion of the first step (such as 1:12), and decocting for a period of time T1 (such as 2 hours);
adding water with an adaptation ratio of two (for example, 1:10), and decocting for a period of T2 (for example, 2 hours);
filtering the decoction, and concentrating until the relative density is more than or equal to L (such as 1.20); wherein the relative density refers to the ratio of the density of the substance to the density of a reference substance, the reference being water, under respective prescribed conditions; the first proportion, the second proportion, the duration of T1, the duration of T2 and the L are all preset numerical values in the formula.
The foregoing are all preferred embodiments of the present application, and are not intended to limit the scope of the present application in any way, therefore: all equivalent changes in structure, shape and principle of this application should be covered in the protection scope of this application.
Claims (8)
1. A hybrid manufacturing process for a mixture for treating osteoporosis, comprising:
step one, preparing a stock solution, which comprises the following steps: bone liquid preparation and other stock solutions preparation;
step two, preparing a mixed material, which comprises the following steps: respectively feeding bone liquid and other stock solutions into different cavities of a preset multi-cavity mixing device, so that the bone liquid and the other stock solutions contact the outer wall of one cavity serving as a mixing cavity;
step three, mixing materials, which comprises the following steps:
based on the height difference between the bone liquid in the multi-layer cavity mixing device and the liquid level in the mixing cavity and the height difference between other stock solutions and the liquid level in the mixing cavity, the bone liquid and other stock solutions are fed into the mixing cavity in a mode of discharging under the action of gravity and/or actively pressurizing and discharging;
stirring the liquid in the mixing cavity by using a stirring mechanism (3) corresponding to the multi-layer cavity mixing device, and controlling the temperature according to the formula in the stirring process;
step four, filtering the mixed solution, which comprises the following steps: and filtering the mixed solution obtained by mixing by using an inorganic membrane to obtain a product stock solution.
2. The hybrid manufacturing process for a mixture for treating osteoporosis according to claim 1, wherein said multi-layered cavity mixing device comprises:
an inner tank body (1), the cavity of which is used as a mixing cavity;
the outer tank body (2) is arranged around the inner tank body (1) and is divided into a bone liquid cavity and at least one other stock liquid cavity;
a stirring mechanism (3) which is mounted on the inner tank (1) and is used for stirring operation;
the liquid level detection module (4) is used for detecting the liquid levels of the mixing cavity, the bone liquid cavity and other stock solution cavities and outputting the liquid levels;
the pressurizing mechanism (5) is used for actively pressurizing the bone liquid cavity and other stock solution cavities;
the wall plate at the inner side of the outer tank body (2) is a side wall of the inner tank body (1), a first through hole for communicating a bone liquid cavity and a second through hole for communicating other stock liquid cavities are formed in the side wall of the inner tank body (1), an adaptive electric control valve I (13) is arranged at the first through hole, and an adaptive electric control valve II (14) is arranged at the second through hole; the upper part of the inner tank body (1) is provided with a ventilation valve (11) and the lower part is provided with a discharge valve (12);
the supercharging mechanism (5) comprises a balance pipe I (51), an electric control valve III (52), an electric cylinder I (53), a piston plate I (54), a balance pipe II (55), an electric control valve IV (56), an electric cylinder II (57) and a piston plate II (58);
the piston plate I (54) is adapted to the cross section of the bone liquid cavity and is vertically connected with the bone liquid cavity in a sliding mode, a cylinder body of the electric cylinder I (53) is fixed to the outer tank body (2) and a rod end of the electric cylinder I is fixed to the piston plate I (54), the balance pipe I (51) penetrates through the outer tank body (2) and the piston plate I (54), the balance pipe I (51) is vertically connected with the outer tank body (2) in a sliding mode, the balance pipe I (51) is fixed to the piston plate I (54), and the electric control valve III (52) is installed on the balance pipe I (51) and is close to the upper portion of the piston plate I (54);
the piston plate II (58) is matched with the cross section of other stock solution cavities and is connected with the other stock solution cavities in a vertical sliding mode, a cylinder body of the electric cylinder II (57) is fixed to the outer tank body (2) and a rod end of the electric cylinder II is fixed to the piston plate II (58), the balance pipe II (55) penetrates through the outer tank body (2) and the piston plate II (58), the balance pipe II (55) is connected with the outer tank body (2) in a vertical sliding mode, the balance pipe II (55) is fixed to the piston plate II (58), and the electric control valve IV (56) is installed on the upper portion of the balance pipe II (55) and close to the piston plate II (58).
3. The hybrid production process for a mixture for the treatment of osteoporosis according to claim 2, characterized in that: the multi-layer cavity mixing device further comprises a controller (6) electrically connected with the liquid level detection module (4), the stirring mechanism (3) and the pressurizing mechanism (5);
the liquid level in the bone liquid cavity is called liquid level A, the liquid levels in other stock solution cavities are called liquid level B, and the liquid level in the mixing cavity is called liquid level C;
when the controller (6) receives a mixing instruction, the liquid level A is larger than a preset bone liquid level lower limit threshold value, the liquid level B is larger than other preset stock solution lower limit threshold values, and the liquid level C is an empty liquid level, the controller (6):
if the liquid level A is greater than the liquid level B, opening the first electric control valve (13) and the third electric control valve (52) and determining the closing time according to the bone liquid proportion in the preset formula and the variation of the liquid level A;
after the first electric control valve (13) is closed, the second electric control valve (14) is opened, when the difference value between the liquid level B and the liquid level C is smaller than the preset minimum liquid level difference, the fourth electric control valve (56) is closed, and the second electric cylinder (57) is stretched until the variation of the liquid level B is matched with the variation of the liquid level A;
if the liquid level B is greater than the liquid level A, opening the second electric control valve (14) and the fourth electric control valve (56) and determining the closing time according to the bone liquid proportion in the preset formula and the variation of the liquid level B;
and after the second electric control valve (14) is closed, the first electric control valve (13) is opened, when the difference value between the liquid level A and the liquid level C is smaller than the preset minimum liquid level difference, the third electric control valve (52) is closed, and the first electric cylinder (53) is extended until the variation of the liquid level A is matched with the variation of the liquid level B.
4. A hybrid production process for a mixture for the treatment of osteoporosis according to claim 3, characterized in that: when the liquid level C is larger than a preset mixing lower limit threshold value, the controller (6) controls the stirring mechanism (3) to execute stirring action.
5. A hybrid production process for a mixture for the treatment of osteoporosis according to claim 3, characterized in that: the liquid level detection module (4) comprises a movable detection unit (41) and a floating ball liquid level meter (42), wherein the floating ball liquid level meter (42) is installed on the inner tank body (1), the movable detection unit (41) comprises a floater (411), a ranging sensor (412) and a guide rail (413), the guide rail (413) is vertically arranged and is provided with a guide groove along the length direction, one side of the floater (411) is fixedly provided with a sliding block, and the sliding block is connected to the guide groove in a sliding manner;
the bone liquid cavity and other stock solution cavities are respectively provided with a movable detection unit (41), a guide rail (413) penetrates through a corresponding first piston plate (54) and a corresponding second piston plate (58), a distance measuring sensor (412) is located above the floater (411) and used for detecting the distance between the distance measuring sensor and the floater (411), and the distance measuring sensor (412) is arranged on the corresponding first piston plate (54) and the corresponding second piston plate (58).
6. The process for the mixed production of a mixture for the treatment of osteoporosis according to claim 5, wherein: the controller (6) obtains the liquid level A and the liquid level B according to the expansion and contraction amount of the first electric cylinder (53), the expansion and contraction amount of the second electric cylinder (57) and the detection value of each ranging sensor (412).
7. The hybrid manufacturing process for a mixture for treating osteoporosis according to claim 1, wherein said bone fluid preparation comprises:
taking bones with the matched formula, and removing residual meat, metamorphism, discoloration and non-bone components;
cleaning and draining;
steaming the drained bone;
crushing the steamed bones, and adding water to grind into bone paste;
adding a pre-acid-base reagent, and adjusting the pH value to a specified pH value;
adding pancreatin and stirring;
removing bone residues in the bone liquid after enzymolysis; the method comprises the steps of,
the bone fluid was filtered with an inorganic membrane.
8. The hybrid production process for a mixture for treating osteoporosis according to claim 1, wherein said other stock solution preparation comprises:
taking traditional Chinese medicinal materials with an adaptive formula; wherein the Chinese medicinal materials comprise radix astragali, radix Codonopsis, ganoderma, fructus Jujubae and Auricularia;
adding water in an adaptive proportion I, and decocting for a period of T1;
adding water with an adaptive proportion II, and decocting for a period of T2;
filtering the decoction liquid, and concentrating until the relative density is more than or equal to L; wherein, the first proportion, the second proportion, the time length T1, the time length T2 and the time length L are all preset values in the formula.
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