CN117695460B - Multifunctional blood recovery device and application method thereof - Google Patents
Multifunctional blood recovery device and application method thereof Download PDFInfo
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Abstract
The invention provides a multifunctional blood recovery device, which comprises a high-flux blood collection tube, a blood active ingredient separation system, a donor blood purification system, a blood active ingredient collection system, a cooling system and an extracorporeal membrane lung device; the purification system is used for removing substances such as viruses in donor blood, the separation system is used for separating erythrocyte components, platelet components and plasma components in the blood, nitric oxide is supplemented in the erythrocyte conveying process to improve activity, the independently controlled refrigerator is used for preserving the erythrocyte components and the platelet components at low temperature, and the extracorporeal membrane lung device is used for realizing rapid recovery of the erythrocyte components. Therefore, the recovery device can perform purification, active ingredient separation and low-temperature storage at the same time of blood collection, and perform rapid recovery before use.
Description
Technical Field
The invention belongs to the field of medical appliances, and particularly relates to a multifunctional blood recovery device for rapidly separating, collecting and storing donor blood at a low temperature and a use method thereof.
Background
Blood is taken as a scarce public resource and plays an important role in saving the life of patients and guaranteeing the diagnosis and treatment of clinical diseases. Blood preparations have a relatively short shelf life and often suffer from seasonal and structural starvation.
Organ transplantation is the only effective way to rescue patients with end organ disease, which often have combined poor clotting function and thrombocytopenia; in addition, the operation of transplanting the hand and the organ is complex, and blood loss is more in the operation, so that sufficient blood storage is often needed, otherwise, the operation cannot be safely performed, and even the life of a patient is seriously threatened.
Although static cold preservation (SCS) is currently the most common technique for organ preservation. However, due to the severe current donor organ shortage situation, all countries in the world have had to take measures to expand donor sources, and edge donors (ECDs), including DCD, elderly, obese, etc., have been adopted, which have significantly increased the incidence of delayed graft function recovery (DGF) and primary graft non-function (PNF), in which point SCS technology has failed to meet clinical needs. In recent years, normal temperature mechanical perfusion can supply blood and oxygen to organs at normal temperature, provides a maintenance environment close to the physiological state of human body, and has remarkable advantages in reducing ischemia reperfusion injury of organs, expanding donor sources and improving the prognosis of transplantation compared with SCS. However, adequate supply of washed red blood cells (typically 8-10U for normothermic perfusion in vitro per organ) remains an important constraint for development of normothermic mechanical perfusion, and therefore, in order to avoid organ waste and to improve the prognosis of transplantation, it is urgent to find a way to alleviate blood supply.
At present, when donated organs are obtained, only solid organs such as heart, lung, liver and kidney are usually obtained, and donor blood is lack of a standard and effective recovery technology, so that precious donor blood resources are wasted. In addition, according to the calculation of normal weight, the total blood in an adult body can reach 4000-5000 ml, so if a complete blood recovery, separation and preservation system for donated donor is established, the blood recovery, separation and preservation system is applied to normal-temperature mechanical perfusion in-vitro organ preservation or operation blood preparation, the current blood tension can be greatly relieved, and the real waste is realized.
Disclosure of Invention
Based on this, the present invention provides a multifunctional blood recovery device for rapid separation, collection, and low-temperature storage of donor blood and a method of using the same.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
a multi-functional blood recovery device, the multi-functional blood recovery device comprising:
the inferior vena cava blood flow collection end comprises a high-flux blood collection tube;
The blood active ingredient separation system comprises a blood storage tank, a five-way pipe, a normal saline cleaning device, a separation pump, a platelet storage tank and a plasma collection bag; the normal saline cleaning device comprises a normal saline storage tank and a flushing pipeline;
a donor blood purification system comprising a linear accelerator, a hemodialysis device, and a leukocyte filtration device;
The blood active ingredient collection system comprises a nitric oxide conveying device and a plurality of blood active ingredient refrigerators, wherein the blood active ingredient refrigerators are respectively communicated with the blood active ingredient separation system through a red blood cell recovery pipeline and a platelet recovery pipeline;
A cooling system;
A rapid resurrection device for blood active ingredients;
The blood collection end of the inferior vena cava is communicated with the blood storage tank through a first pipeline, the blood storage tank is communicated with the first end of the five-way pipe through a second pipeline, the second end of the five-way pipe is communicated with the flushing pipeline of the normal saline cleaning device, the third end of the five-way pipe is communicated with the red blood cell recovery pipeline, the fourth end of the five-way pipe is communicated with the separation pump through a two-way cover, and the fifth end of the five-way pipe is communicated with the platelet storage tank through a return pipeline.
Further, the multifunctional blood recovery device is further provided with an anticoagulation system, the anticoagulation system is provided with an anticoagulant storage tank, the anticoagulant storage tank is communicated with the first pipeline through an anticoagulant pipeline, and the anticoagulant pipeline is connected between the inferior vena cava blood flow collection end and the blood storage tank.
Further, in the blood active ingredient separation system, a blood storage tank, a five-way valve separation pump, a platelet storage tank and a blood plasma collection bag are sequentially communicated, the two-way cover is installed on a pump head of the separation pump and is communicated with a centrifugal cup of the separation pump, a first end of the two-way cover is communicated with a fourth end of the five-way pipe, a second end of the two-way cover is communicated with the platelet storage tank through a third pipeline, and the blood plasma collection bag is communicated with the platelet storage tank through a blood plasma collection pipeline.
Further, in the donor blood purification system, the linear accelerator is arranged at one side of the blood storage tank, and the ray output end is opposite to the blood storage tank, so that free tumor cells remained in donor blood can be killed; the dialysis device and the leukocyte-filtering device are arranged on the second pipeline, wherein the hemodialysis device is arranged above the leukocyte-filtering device.
Further, in the blood active ingredient collecting system, a first end of the red blood cell recovery pipeline is communicated with a third end of the five-way pipe, a second end of the red blood cell recovery pipeline is provided with a plurality of recovery branch pipes, and the recovery branch pipes are respectively communicated with a plurality of blood active ingredient refrigerators in a one-to-one correspondence manner; the first end of platelet recovery pipeline with platelet storage tank intercommunication, the second end of platelet recovery pipeline is provided with many recovery branch pipes, many recovery branch pipes respectively with a plurality of blood active ingredient fridge one-to-one intercommunication.
Further, the nitric oxide delivery device comprises a nitric oxide storage tank, a gas throttle valve is arranged at the opening of the nitric oxide storage tank, the gas throttle valve is communicated with the first end of the gas delivery pipeline through a gas-tight joint, and the second end of the gas delivery pipeline is communicated with the red blood cell recovery pipeline through a gas valve.
Further, the cooling system comprises a compressor, a cooling fan and a condensing pipeline, wherein the compressor and the cooling fan are arranged in the areas near the plurality of blood active ingredient refrigerators; the plurality of condensation pipelines are arranged at the periphery of the plurality of blood active ingredient refrigerators in a one-to-one correspondence manner.
Further, the blood active ingredient rapid retsu device comprises an outer membrane lung device, a plurality of blood active ingredient refrigerators are communicated with the outer membrane lung device through an upper total output pipeline, a water bath circulation pipeline and an active ingredient circulation pipeline are arranged in the outer membrane lung device, the water bath circulation pipeline and the active ingredient circulation pipeline are all in spiral and parallel, warm water flowing through the water bath circulation pipeline exchanges heat with blood active ingredients in the active ingredient circulation pipeline, and oxygen enters the blood active ingredient circulation pipeline through an oxygen therapy pipeline and is mixed with the blood active ingredients.
Further, the multifunctional blood recovery device further comprises a centrifugal pump, a throttle valve, a negative pressure suction source and a quick connector, at least part of the pipeline is provided with the centrifugal pump and the throttle valve, the blood storage tank and the platelet storage tank are respectively provided with the negative pressure suction source communicated with the tank cavity of the blood storage tank, and the quick connector is arranged at the joint between the pipeline and between the two-way valve and the junction between the two-way cover and the blood storage tank and the junction between the platelet storage tank and the blood active ingredient refrigerator.
Further, a method for using the multifunctional blood recovery device is also included, comprising the steps of:
1) Blood collection is carried out through a high-flux blood collection tube, and an anticoagulation system is communicated;
2) Starting a donor blood purification system to purify blood;
3) When the donor blood in the centrifugal cup reaches a certain threshold value, temporarily closing the second pipeline, starting the separation pump, and separating the effective components of the blood for the first time;
4) Controlling the normal saline flushing liquid to flow into the five-way pipe through the flushing pipeline, and enabling the blood plasma and the blood platelet components to flow into the blood platelet storage tank through the third pipeline together with the mixed liquid of the normal saline;
5) Opening a valve of a red blood cell recovery pipeline, a valve of a nitric oxide storage tank and a valve of a gas conveying pipeline, adjusting the flow of nitric oxide in the gas conveying pipeline, controlling the temperature of a blood active ingredient refrigerator, and refrigerating red blood cell ingredients in the refrigerator at a low temperature;
6) When the red blood cell component in the centrifugal cup completely flows out, controlling the platelet and the plasma component to flow into the five-way pipe again through the return pipeline, and flowing into the centrifugal cup through the two-way cover to separate effective components of blood for the second time;
7) Controlling the normal saline flushing liquid to flow into the five-way pipe again through the flushing pipeline, and enabling the plasma and the mixed liquid of the normal saline to flow into the platelet storage tank through the third pipeline together;
8) Opening a valve of a platelet recovery pipeline, controlling the temperature of a blood active ingredient refrigerator, and refrigerating the platelet ingredients in the refrigerator at a low temperature;
9) After the platelet component in the centrifuge cup has completely flowed out, reopening the second tube and repeating steps 3) -8);
10 The red blood cell component enters the external membrane lung device, the warm water is controlled to flow into a water bath circulation pipeline in the external membrane lung device, and the warm water exchanges heat with the red blood cell component in the blood effective component circulation pipeline, so that the recovery of the low-temperature frozen red blood cell is realized;
11 The red blood cell component is output to the outside for standby through a lower total output pipeline.
Compared with the prior art, the invention has the following characteristics and beneficial effects:
The high-flux blood collection tube with the micropores is used for collecting blood from the lower vena cava cannula in the cannula blood collection operation of the donor blood, so that the effective recovery area of the lower vena cava blood is greatly increased, the blood recovery amount in unit time is increased, the rapid and sufficient collection of the donor blood is realized, and the collection efficiency of the donor blood and the physiological activity of the donor blood are ensured compared with the traditional cannula blood collection mode;
Compared with the traditional donor blood collection, the blood purification system consisting of the linear accelerator, the hemodialysis device and the leucocyte filter is arranged, so that the tumor cells, viruses, immune cells, metabolic wastes and other components in the donor blood are effectively removed synchronously in the dynamic process of blood collection, and the blood purification system can be directly used for clinical use without additional treatment after the blood collection is completed, thereby greatly reducing the treatment cost of the donor blood, expanding the blood donor population for collecting the blood and simplifying the process of reutilizing the donor blood;
Compared with the traditional donor blood collection mode, the blood active ingredient separation system with the return pipeline and the blood active ingredient collection system realize independent and continuous separation, recovery, split charging and preservation of red blood cell ingredients, platelet ingredients and plasma ingredients in the dynamic process of blood collection, and the blood active ingredient separation system does not need to manually separate each blood constituent ingredient after the collection of the donor blood is completed, so that the independent use of one or a plurality of blood constituent ingredients in clinic is realized, the treatment cost of the donor blood is greatly reduced, and the mode of recycling the donor blood is refined;
Compared with the traditional donor blood collection process, the cold storage box with the independent refrigerating units and the self-defined use quantity of the blood effective components realizes the synchronous low-temperature freezing storage of the blood components in the dynamic process of blood collection, and can realize the independent temperature control of any one or a plurality of cold storage boxes, thereby flexibly realizing the sealed storage of a plurality of different temperatures of different blood components;
Compared with the traditional donor blood collection and storage, the nitric oxide delivery system for collecting and storing the red blood cell components realizes the real-time nitric oxide supplementation of the red blood cell components, so that the deformation and the reduction of the oxygen carrying capacity of the red blood cells caused by lack of nitric oxide are improved in long-time low-temperature storage, and the red blood cells still have ideal physiological activity when being output again for clinical use, thereby further improving the curative effect of red blood cell transfusion;
Compared with the traditional clinical reuse of donor blood, the extracorporeal membrane lung device is arranged, so that the blood active ingredient frozen for a long time at low temperature can realize rapid resurrection, the rapid recovery of the oxygen carrying capacity of red blood cells is realized, the process of the clinical reuse of the blood active ingredient is greatly simplified, and the extracorporeal membrane lung device can play an important role in being used for rescuing special clinical situations such as acute massive hemorrhage patients.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some examples of the present invention and therefore should not be considered as limiting the scope, and other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic structural diagram of a multifunctional blood recovery device for rapidly collecting, separating and storing donor blood at low temperature according to an embodiment of the present patent.
In the figure: a-a blood donor; b-donor heart; c-donor inferior vena cava;
01-high flux blood collection tube; 01 a-quick connector; 02-an anticoagulant reservoir; 03-anticoagulant throttle valve;
04-a first centrifugal pump; 05-an anticoagulant tube; 05 a-a first valve; 06-a first conduit;
06 a-a first negative pressure suction source; 07-a blood reservoir; 07 a-quick connector; 08-a second conduit; 08 a-quick connector; 09-a second centrifugal pump; 10-physiological saline storage tank; 10 a-quick connector; 11-physiological saline throttle valve;
12-flushing the pipeline; 12 a-quick connector; 13-a third centrifugal pump; 14-five-way pipe; 14a, 14 b-quick connector; 15-two-way cover; 15a, 15 b-quick connector;
16-separating pump head; 17-a separation pump centrifuge cup, a centrifuge well (not shown); 18-a fourth centrifugal pump; 19-a red blood cell recovery line;
19a 1-19 an-a first red fine recovery pipeline valve-an nth red cell recovery pipeline valve;
19b1 to 19 bn-a first red blood cell recovery branch pipe to an nth red blood cell recovery branch pipe;
19c 1-19 cn-first red blood cell recovery pipeline quick connector-nth red blood cell recovery pipeline quick connector;
20-a third pipe; 20-a third pipe; 20 a-a second negative pressure suction source; 21-platelet storage tank;
21a, 21b, 21 c-quick connectors; 22-return piping; 22 a-quick connector; 23-a fifth centrifugal pump;
24-a plasma collection tube; 24 a-quick connector; 25-a plasma collection bag; 26-sixth centrifugal pump;
27-platelet recovery tubing;
27a 1-27 an-first platelet recovery conduit valve-nth platelet recovery conduit valve;
27b1 to 27 bn-a first platelet recovery branch pipe to an nth platelet recovery branch pipe;
27c 1-27 cn-first platelet recovery conduit quick connectors-n-th platelet recovery conduit quick connectors;
28-1 to 28-n-first blood active ingredient refrigerator to nth blood active ingredient refrigerator;
28a 1-28 an-first to nth fridge quick connectors;
29-1 to 29-n-first to nth output pipes; 29 b-upper total output pipe;
29a 1-29 an-first output valve-nth output valve; 29 c-quick connector; 30-nitric oxide storage tank;
30 a-nitric oxide reservoir valve; 30 b-an airtight joint; 31-a gas delivery conduit;
31 a-a gas delivery conduit valve; 32-an air pump; 33-extra-corporal membrane lung; 33a, 33 b-quick connector;
34-warm water input pipeline; 34 a-quick connector; 35-an oxygen therapy pipeline; 35 a-quick connector;
36-a cold water output pipe; 37-lower main output pipe;
38-seventh centrifugal pump; 39-compressor; 40-cooling fans;
40a 1-40 an-first to nth condensing duct valves;
41-1 to 41-n-first to nth condensing pipes;
42-1 to 42-n-first to nth refrigerant throttle valves; 43-linac; 44-hemodialysis apparatus;
45-leukocyte filtration device.
Detailed Description
In the description of the present invention, it should be understood that references to orientation descriptions, such as directions of up, down, left, right, etc., are based on the orientation or positional relationship shown in the drawings, are merely for convenience of description and simplification of the description, and do not indicate or imply that the apparatus or element in question must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as limiting the invention.
In the description of the present invention, several means one or more, and plural means two or more. The description of the first and second is for the purpose of distinguishing between technical features only and should not be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated or implicitly indicating the precedence of the technical features indicated.
In the description of the present invention, unless explicitly defined otherwise, terms such as arrangement, connection, communication, introduction, etc. should be construed broadly and the specific meaning of the terms in the present invention can be reasonably determined by those skilled in the art in combination with the specific contents of the technical scheme.
In the description of the present invention, reference to the term "one embodiment," "some embodiments," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment is included in at least one embodiment of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment. Furthermore, the particular features, structures, materials, or characteristics may be combined in any suitable manner in any one or more embodiments.
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present invention without making any inventive effort, are intended to fall within the scope of the present invention.
Example 1
The present embodiment provides a multifunctional blood recovery device capable of rapidly separating, collecting, and cryogenically storing donor blood, the structure of which is described below in conjunction with fig. 1:
The device comprises a high-flux blood collection tube 01, wherein the head end of the high-flux blood collection tube 01 is inserted into the right atrium of a donor along the inferior vena cava of the donor, and dense micropores are arranged on the high-flux blood collection tube 01; the high-throughput blood collection tube 01 communicates with the first end of the first conduit 06 through the quick connector 01 a; the second end of the first conduit 06 communicates with the blood reservoir 07.
The anticoagulant tank 02 communicates with a first end of the anticoagulant tube 05 through a quick connector 02 a; the second end of the anticoagulant tube 05 is connected with the first tube 06 through a first valve 05 a; the anticoagulant throttle 03 and the first centrifugal pump 04 are both arranged on the anticoagulant line 05, wherein the anticoagulant throttle 03 is arranged above the first centrifugal pump 04.
The tank cavity of the blood storage tank 07 is communicated with the second end of the first pipeline 06, and the tank cavity of the blood storage tank 07 is also communicated with the first negative pressure suction source 06 a; the first negative pressure suction source 06a can be used for manufacturing the pressure difference between the first pipeline 06 and the inside of the tank cavity of the blood storage tank 07, so that donor blood smoothly flows into the tank cavity of the blood storage tank 07 through the first pipeline 06 under the action of the pressure difference; the blood reservoir 07 communicates with the first end 08 of the second conduit 08 via a quick connector 07a with a throttle valve; the second end of the second conduit 08 communicates with the first end of the five-way tube 14 via a quick connector 08 a. The second centrifugal pump 09 is disposed on the second pipe 08, and when the donor blood reserve in the blood storage tank 07 reaches a certain volume, the throttle valve of the quick connector 07a can be manually opened, so that the blood flows into the second pipe 08 under the action of the pressure difference in the pipe manufactured by the second centrifugal pump, and then enters the five-way pipe 14.
The linear accelerator 43 is arranged on one side of the blood storage tank 07, when blood is stored in the blood storage tank 07 for a short time, the linear accelerator 43 can be manually started, the ray output end of the linear accelerator 43 is opposite to the blood storage tank 07, and the purpose of killing the residual free tumor cells in the donor blood can be achieved by irradiating the donor blood; the hemodialysis unit 44 and the leukocyte filtering unit 45 are both arranged on the second duct 08, wherein the hemodialysis unit 44 is arranged above the leukocyte filtering unit 45.
The first end of the five-way pipe 14 is communicated with the second pipeline 06 through a quick connector 08a with a throttle valve, the second end of the five-way pipe 14 is communicated with the flushing pipeline 12 through a quick connector 12a, the third end of the five-way pipe 14 is communicated with the red blood cell recovery pipeline through a quick connector 14b, the fourth end of the five-way pipe 14 is communicated with the two-way cover 15 through a quick connector 14a, and the fifth end of the five-way pipe 14 is communicated with the return pipeline through a quick connector 22 a.
The first end of the two-way cover 15 is communicated with the five-way pipe 14 through a quick connector 14a, the second end of the two-way cover 15 is communicated with the third pipeline 20 through a quick connector 15a, and the two-way cover 15 is arranged on a pump head 16 of the separation pump and is communicated with a centrifugal cup 17 of the separation pump; the first end of the third pipe 20 is communicated with the second end of the two-way cover 15 through the quick connector 15a, and can be used for guiding the secondary separation components in the centrifugal process and the centrifugal cup flushing process; the tank cavity of the platelet storage tank 21 is communicated with the third pipeline 20, the tank cavity of the platelet storage tank 21 is also communicated with the second negative pressure suction source 20a, and the platelet storage tank 21 can be used for temporarily storing secondary separation components in the centrifugation process and the flushing process of the centrifugal cup; the second negative pressure suction source 20a may be used to create a pressure differential between the interior of the third conduit 20 and the interior of the tank cavity of the platelet storage tank 21 such that donor blood smoothly flows into the tank cavity of the platelet storage tank 21 through the third conduit 20 under the pressure differential.
The normal saline storage tank 10 is communicated with the first end of the flushing pipeline 12 through a quick connector 10a, and the second end of the flushing pipeline 12 is communicated with the second end of the five-way pipe 14 through a quick connector 12a with a throttle valve; the third centrifugal pump 13 is disposed on the flushing pipe 12, and the third centrifugal pump 13 can pump the normal saline flushing liquid in the normal saline storage tank 10 into the centrifugal cup 17 through the flushing pipe 12, the five-way pipe 14 and the two-way cover 15 by making the pressure difference in the pipe, so that the platelet plasma mixed liquid to be separated in the centrifugal cup 17 after the first centrifugation and the residual plasma components to be separated in the centrifugal cup 17 after the second centrifugation are flushed into the platelet storage tank 21 through the third pipe 20.
The first end of the red blood cell recovery pipeline 19 is communicated with the fourth end of the five-way pipe 14 through a quick connector 14b with a throttle valve; the second end of the red blood cell recovery pipeline 19 is provided with a plurality of tail ends, the second end of the red blood cell recovery pipeline 19 is communicated with the first end of the first red blood cell recovery branch pipe 19b1 through a first red blood cell recovery pipeline valve 19a1, and the second end of the first red blood cell recovery branch pipe 19b1 is communicated with the first blood active ingredient refrigerator through a quick connector 19c 1; by analogy, the nth end of the red blood cell recovery pipeline 19 is communicated with the first end of the nth red blood cell recovery branch pipe 19bn through an nth red blood cell recovery pipeline valve 19an, and the second end of the nth red blood cell recovery branch pipe is communicated with the nth blood active ingredient refrigerator through a quick connector 19 cn; the fourth centrifugal pump 18 is provided on the red blood cell recovery tube 19, and the fourth centrifugal pump 18 can make the pressure difference in the tube so that the red blood cells left in the centrifugal cup 17 after the first centrifugation are sucked into the red blood cell recovery tube 19 through the two-way cover 15 and the five-way tube 14.
The nitric oxide storage tank 30 is provided with a gas throttle valve 30a at the opening, the gas throttle valve 30a is communicated with the first end of a gas conveying pipeline 31 through a gas-tight joint 30b, and the second end of the gas conveying pipeline 31 is communicated with the red blood cell recovery pipeline 19 through a gas valve 31 a; an air pump 32 is provided on the gas delivery pipe 31, and the air pump 32 pumps the nitric oxide gas in the nitric oxide storage tank 30 into the red blood cell recovery pipe 19 by making a difference in the in-pipe pressure of the gas delivery pipe 31.
The first end of the plasma collecting conduit 24 communicates with the platelet tank 21 via a quick connector 21b with a throttle valve, and the second end of the plasma collecting conduit 24 communicates with the plasma collecting bag 25 via a quick connector 24a, the plasma collecting bag 25 being adapted to receive the plasma residual fraction temporarily stored in the platelet tank 21 for further processing after the second separation and flushing has been completed and the valve of the quick connector 21b is opened.
The first end of the return pipe 22 is communicated with the platelet storage tank 21 through a quick connector 21a with a throttle valve, and the second end of the return pipe 22 is communicated with the fifth end of the five-way pipe 14 through a quick connector 22a with a throttle valve; the fifth centrifugal pump 23 is provided on the return pipe 22, and the fifth centrifugal pump 23 pumps the platelet plasma mixture temporarily stored in the platelet tank 21 after the first centrifugation back to the five-way pipe 14 through the return pipe 22 by making an internal pressure difference between the return pipe 22 and the platelet tank 21, and then is flushed with the normal saline flushing liquid again into the centrifugal cup 17 through the two-way cover 15 for the second centrifugation.
The first end of the platelet recovery conduit 27 communicates with the platelet reservoir via a quick connector 21c with a throttle valve; the second end of the platelet recovery pipeline 27 is provided with a plurality of tail ends, the second end of the platelet recovery pipeline 27 is communicated with the first end of the first platelet recovery branch pipe 27b1 through the first platelet recovery pipeline valve 27a1, and the second end of the first platelet recovery branch pipe 27b1 is communicated with the first blood active ingredient refrigerator through the quick connector 27c 1; by analogy, the nth end of the platelet recovery pipeline 27 is communicated with the first end of the nth platelet recovery branch pipe 27bn through an nth platelet recovery pipeline valve 27an, and the second end of the nth platelet recovery branch pipe is communicated with the nth blood active ingredient refrigerator through a quick connector 27 cn; the sixth centrifugal pump 26 is provided on the platelet recovery tube 27, and the sixth centrifugal pump 26 can make the pressure difference in the tube so that the platelets washed into the centrifugal cup 17 after the second centrifugation are sucked into the platelet recovery tube 27.
The first blood active ingredient refrigerator 28-1 communicates with the second end of the first red blood cell recovery branch pipe 19b1 through the quick connector 19c1, the first blood active ingredient refrigerator 28-1 communicates with the second end of the first platelet recovery pipe 27c1 through the quick connector 27c1, and the first blood active ingredient refrigerator 28-1 communicates with the first end of the first output pipe through the quick connector 28a1 with a throttle valve; by analogy, the nth blood active ingredient refrigerator 28-n communicates with the second end of the nth red blood cell recovery branch 19bn by means of the quick connector 19cn, the nth blood active ingredient refrigerator 28-n communicates with the second end of the nth platelet recovery tube 27cn by means of the quick connector 27cn, and the nth blood active ingredient refrigerator 28-n communicates with the first end of the nth output tube by means of the quick connector 28an with a throttle valve.
The first end of the upper main output pipe 29b is provided with a plurality of ends, and the first end of the upper main output pipe 29b is communicated with the second end of the first output pipe 29-1 through a first output valve 29a 1; similarly, a first end of the upper main output conduit 29b communicates with a second end of the nth output conduit 29-n through an nth output valve 29 an; the second end of the upper total output conduit 29b communicates with the extra-corporeal lung device 33 via a quick connector 29 c.
The compressor 39 and the cooling fan 40 are disposed in the vicinity of the blood active ingredient refrigerators 28-1 to 28-n; the 1 st condensation pipeline 41-1 st to n th condensation pipelines 41-n are arranged at the periphery of the first blood effective component refrigerator 28-1 st to n th blood effective component refrigerator 28-n so as to ensure that the blood effective components in the refrigerator are fully cooled in real time when the refrigerator is in a working state; the 1 st condensation duct valve 40a1 to the n th condensation duct valve 40an are respectively arranged at the upper ends of the first condensation duct 41-1 to the n th condensation duct 41-n, so that an operator can determine the opening state of the corresponding condensation duct according to the actual demand of the blood effective component refrigerator, thereby reducing unnecessary energy consumption; the 1 st refrigerant throttle valve 42-1 to the n th refrigerant throttle valve 42-n are respectively arranged at the lower ends of the first condensation pipeline 41-1 to the n th condensation pipeline 41-n, so that an operator can adjust the refrigerant flow of the corresponding condensation pipeline according to the actual working state of the working blood effective component refrigerator, thereby realizing the change of the refrigeration temperature.
The extracorporeal membrane unit 33 communicates with the second end of the upper general output conduit 29b via a quick connector 29 c; the extracorporeal membrane unit 33 communicates with a first end of the lower total output conduit 37 via a quick connector 33 a; the first end of the warm water input pipeline 34 is communicated with an external warm water source, and the second end of the warm water input pipeline 34 is communicated with a water bath running pipeline in the extracorporeal membrane unit 33 through a quick connector 34 a; the first end of the oxygen-delivering pipeline 35 is communicated with an external oxygen source, and the second end of the oxygen-delivering pipeline 35 is communicated with a blood active ingredient flow pipeline in the extracorporeal membrane apparatus 33 through a quick connector 35 a; a first end of the cold water output pipeline 36 is communicated with a water bath flow pipeline of the extracorporeal membrane lung apparatus 33 through a quick connector 33b, and a second end of the cold water output pipeline 36 is communicated with an external cold water receiving apparatus; the seventh centrifugal pump 38 is disposed on the lower total output pipe 37, and the seventh centrifugal pump 38 can assist the blood to flow out of the extracorporeal membrane-lung apparatus 33 and smoothly output to the outside of the apparatus for clinical use by making a difference in-pipe pressure of the lower total output pipe 37.
Example two
Based on the multifunctional blood recovery device for rapidly separating, collecting and storing donor blood at low temperature provided in the previous embodiment, a method for rapidly separating, collecting and storing blood at low temperature is provided, and the specific process includes:
1) Blood collection
The method comprises the steps of conventional disinfection, towel spreading, sequential incision of skin, subcutaneous muscle layers and peritoneum on a large cross-shaped approach path of abdomen, exposure of abdominal cavity subcuticular veins by an automatic drag hook, clamping and closing of a proximal vascular clamp of the subcuticular veins, far-end ligation, incision of the subcuticular veins by a horizontal incision in a line shape at a position far away from a clamping position at the middle section, upward insertion of a first end of a high-flux blood collection tube 01 into a residual end of the subcuticular veins above the incision, and fixation of the high-flux blood collection tube 01 and communication of a second end of the high-flux blood collection tube 01 with a first pipeline 06 after the correct insertion of the cannula.
2) Blood purification, specifically comprising:
(1) Communicating the pipelines:
Communicating the first conduit 06 with a second end of the anticoagulant conduit 05, the second end of the first conduit 05 communicating with the blood reservoir 07, and the first negative pressure suction source 06a communicating with the blood reservoir 07;
The blood storage tank 07 is communicated with a second pipeline 08, and the second pipeline 08 is communicated with a five-way pipe 14; the centrifugal cup 17 is communicated with the pump head 16 of the separation pump, and the two-way cover 15 is communicated with the pump head 16 of the separation pump; the two-way cover 15 is communicated with the five-way pipe 14 and the two-way cover 15, and the two-way cover 15 is communicated with the third pipeline 20; the third pipeline 20 is communicated with the platelet storage tank 21, and the second negative pressure suction source 20a is communicated with the platelet storage tank 21;
the return pipeline 22 is communicated with the blood storage tank 21, and the return pipeline 22 is communicated with the five-way pipe 14; the normal saline storage tank 10 is communicated with the flushing pipeline 12, and the flushing pipeline 12 is communicated with the five-way pipe 14; a plasma collection tube 24 is in communication with the platelet reservoir 21, and the plasma collection tube 24 is in communication with a plasma collection bag 25;
The red blood cell recovery pipeline 19 is communicated with the five-way pipe 14, the nitric oxide storage tank 30 is communicated with the gas conveying pipeline 31, and the gas conveying pipeline 31 is communicated with the red blood cell recovery pipeline 19; the red blood cell recovery pipeline 19 is respectively communicated with the first red blood cell recovery branch pipe 19b1 to the nth red blood cell recovery branch pipe 19bn, and the first red blood cell recovery branch pipe 19b1 to the nth red blood cell recovery branch pipe 19bn are respectively communicated with the first blood effective component refrigerating boxes 28-1 to the nth blood effective component refrigerating boxes 28-n;
The platelet collection tube 27 is communicated with the platelet storage tank 21, the platelet collection tube 27 is respectively communicated with the first platelet collection branch tube 27b1 to the nth platelet collection branch tube 27bn, and the first platelet collection branch tube 27b1 to the nth platelet collection branch tube 27bn are respectively communicated with the first blood active ingredient refrigerator 28-1 to the nth blood active ingredient refrigerator 28-n;
The first output pipelines 29-1 to the nth output pipelines 29-n are respectively communicated with the first blood effective component refrigerators 28-1 to the nth blood effective component refrigerators 28-n, and the first output pipelines 29-1 to the nth output pipelines 29-n are respectively communicated with the upper total output pipeline 29 b; the upper main output pipeline 29b is communicated with the external membranous device, the warm water input pipeline 35 is communicated with the external membranous device 33, the cold water output pipeline 36 is communicated with the external membranous device 33, the oxygen delivery pipeline 35 is communicated with the external membranous device 33, and the lower main output pipeline 37 is communicated with the external membranous device 33.
(2) Blood collection
Opening the first valve 05a, the first negative pressure suction source 06a and the valve of the quick connector 07a, and opening the second centrifugal pump 09; donor blood is drawn into the high-throughput blood collection tube 01 by the first negative pressure suction source 06a, then into the first conduit 06, then into the blood reservoir 07 and collected there.
(3) Blood purification
When the donor blood starts to flow into the blood tank 07, the linac 43 is turned on to irradiate the blood tank, thereby effectively killing free tumor cells possibly mixed in the blood while not damaging blood cells in the donor blood.
After the donor blood in the blood storage tank 07 reaches a certain volume, opening a valve of the quick connector 07a and a valve of the quick connector 08a, and under the action of the second centrifugal pump 09, the donor blood in the blood storage tank 07 enters the five-way pipe 14 through the second pipeline 08, and at the moment, the throttle valves of the quick connector 08a, the quick connector 12a, the quick connector 14b and the quick connector 22a are all in a closed state, and then the blood flows into the centrifugal cup 17 of the separation pump through the two-way cover 15; when the donor blood flows into the second channel 08, the hemodialysis device 44 is turned on, and the donor blood sequentially passes through the hemodialysis device 44 and the leukocyte filtering device 45 provided on the second channel 08, and the residual metabolic waste products in the blood and the leukocyte components in the blood that may induce immune responses are removed therefrom.
3) Separation of erythrocyte components and low temperature preservation
When the donor blood in the centrifugal cup reaches a certain volume, temporarily closing the valve of the quick connector 07a, the valve of the quick connector 08a and the second centrifugal pump 09, starting the separation pump rotary head 16 to drive the centrifugal cup 17 and the donor blood therein to rotate at a high speed, and separating effective components of the first blood;
After the separation of the effective components of the first blood is finished, the red blood cell components are positioned on the periphery side of the centrifugal cup 17, the blood platelets and blood plasma are positioned on the center side of the centrifugal cup 17, at the moment, the physiological saline throttle valve 11 and the valve of the quick connector 12a are opened, the third centrifugal pump 13 is opened, the second negative pressure suction source 20a is opened, the physiological saline flushing liquid flows into the five-way pipe through the flushing pipeline 12 and then flows into the centrifugal cup 17 of the separation pump through the two-way cover 25, and after being mixed with the blood plasma and the blood platelets positioned on the center side of the centrifugal cup 17, the mixed liquid of the blood plasma and the blood platelets and the physiological saline flows into the blood platelet storage tank through the third pipeline 20 under the action of the second negative pressure suction source 20 a;
At this time, the red blood cell component remains on the outer peripheral side of the centrifugal cup 17, the second negative pressure suction source 20a is closed, the valves of the quick connector 08a and the quick connector 12a are closed, the valve of the quick connector 14b is opened, the 1 st red blood cell recovery pipeline valve 19a1 to the m th red blood cell recovery pipeline valve 19am are opened (in the embodiment, m represents the total usage amount of the blood effective component refrigerator for preserving the red blood cell component determined according to actual needs, and m is the same as below, wherein m is 1.ltoreq.m), the nitrogen monoxide storage pipeline valve 30a and the gas delivery pipeline valve 30b are opened, the flow rate of nitrogen monoxide in the gas delivery pipeline 31 is regulated, the fourth centrifugal pump 18 and the air pump 32 are opened, and a proper amount of nitrogen monoxide gas in the nitrogen monoxide storage tank 30 is input into the red blood cell recovery pipeline 19 from the gas delivery pipeline valve 31a through the gas delivery pipeline 31 under the action of the air pump 32 and is mixed with the red blood cell component therein;
The red blood cell components flow into the x RBC th blood active ingredient refrigerating boxes 28-x RBC to 28-y RBC by the red blood cell recovery pipeline 19, the 1 st red blood cell recovery branch 19b1 to the m th red blood cell recovery branch 19bm under the action of the fourth centrifugal pump 18, and are gathered in the x RBC th blood active ingredient refrigerating boxes 28-y RBC (in the embodiment, x RBC represents the serial numbers of the first blood active ingredient refrigerating boxes selected for containing the red blood cell components from small to large in sequence, and y RBC represents the serial numbers of the last blood active ingredient refrigerating boxes selected for containing the red blood cell components from small to large in sequence, wherein x RBC、yRBC satisfies the requirement of 1 x RBC＜yRBC m); after all the red blood cell components enter a z RBC (wherein z RBC is more than or equal to 1 and less than or equal to x RBC≤zRBC≤yRBC and less than or equal to m) effective component refrigerator 28-z RBC, a compressor 39 is started, a corresponding z RBC condensation pipeline valve 40az RBC is started, a corresponding z RBC refrigerant throttle valve 42-z RBC is opened, the refrigerant flow of a z RBC condensation pipeline 41-z RBC is adjusted, and the temperature of a z RBC effective component refrigerator 28-z RBC is controlled, so that the low-temperature refrigeration function of the z RBC effective component refrigerator 28-z RBC on the red blood cell components in the effective component refrigerator is realized.
4) Platelet component separation and cryopreservation
Meanwhile, after the red blood cell component completely flows out of the five-way pipe 14, for the blood platelet and the blood plasma component temporarily stored in the blood platelet storage tank 21, the valve of the quick connector 14b is closed, the valve of the quick connector 21a and the valve of the quick connector 22a are opened, the fifth centrifugal pump 23 is opened, and the blood platelet and the blood plasma component flow into the five-way pipe 15 again through the return pipeline 22 under the action of the fifth centrifugal pump 23, and then flow into the centrifugal cup 17 again through the two-way cover 15;
when the blood platelets and the plasma components in the centrifugal cup reach a certain volume, the valve of the quick connector 22a is temporarily closed, the fifth centrifugal pump 23 is temporarily closed, and the separation pump rotating head 16 is started again to drive the centrifugal cup 17 and donor blood therein to rotate at a high speed, so that the effective components of the blood are separated for the second time;
After the separation of the effective components of the secondary blood is finished, the platelet components are positioned on the outer peripheral side of the centrifugal cup 17, the plasma components are positioned on the central side of the centrifugal cup 17, at the moment, the physiological saline throttle valve 11 and the valve of the quick connector 12a are opened again, the third centrifugal pump 13 is opened, the second negative pressure suction source 20a is opened, the physiological saline flushing liquid flows into the five-way pipe through the flushing pipeline 12 and then flows into the centrifugal cup 17 of the separation pump through the two-way cover 25, and after being mixed with the plasma components positioned on the central side of the centrifugal cup 17, the mixed liquid of the plasma components and the physiological saline flows into the platelet storage tank 21 again through the third pipeline 20 under the action of the second negative pressure suction source 20 a;
Closing the second negative pressure suction source 20a, opening the valve of the quick connector 21b, wherein the valves of the quick connector 21a and the quick connector 21c are in a closed state, and the mixed solution of the blood plasma component and the normal saline in the blood platelet storage tank flows into the blood plasma collection bag 25 through the blood plasma collection pipeline 24; continuously opening the valves of the physiological saline throttle valve 11 and the quick connector 21b until the physiological saline flushing liquid completely flushes the plasma components in the platelet storage tank 21 into the plasma collecting bag 25, and closing the valves of the physiological saline throttle valve 11 and the quick connector 21 b;
The second negative pressure suction source 20a is turned on, and under the action of the second negative pressure suction source 20a, platelets located on the outer peripheral side of the separation pump centrifuge cup 12 after the plasma component and the physiological saline are mixed, also flow into the platelet storage tank 21 through the third pipe 20;
Closing the second negative pressure suction source 20a, opening the valve of the quick connector 21c, opening the 1 st platelet recovery pipeline valve 27a1 to the t-th platelet recovery pipeline valve 27at (in the embodiment, t represents the total usage number of the blood active ingredient refrigerators for storing platelet ingredients determined according to actual needs, hereinafter, t is equal to or less than 1 t.ltoreq.n), opening the sixth centrifugal pump 26, and under the action of the sixth centrifugal pump 26, the platelet ingredients flow into the x PLT blood active ingredient refrigerators 28-x PLT to y PLT through the platelet recovery pipeline 27b1 to the m-th red blood cell recovery branch pipeline 27bt and are gathered therein (in the embodiment, x PLT represents the number of the blood active ingredient refrigerators for storing platelet ingredients selected for Cheng Fangxie in sequence from small number to large, y PLT represents the number of the blood active ingredient refrigerators selected for storing platelet ingredients selected for Cheng Fangxie in sequence from small number to large, and x PLT、yPLT is equal to or less than the last blood active ingredient refrigerator selected for storing platelet ingredients selected for storing the platelet ingredients selected for 6283 in sequence from small number to No. 62, x PLT、yPLT); after all the platelet components enter the z PLT (wherein z PLT meets 1.ltoreq.x PLT≤zPLT≤yPLT.ltoreq.t) blood active ingredient refrigerator, the compressor 39 is started, the corresponding z PLT condensation pipeline valve 40az PLT is opened, the corresponding z PLT refrigerant throttle valve 42-z PLT is opened, the refrigerant flow of the z PLT condensation pipeline 41-z PLT is adjusted, the temperature of the z PLT blood active ingredient refrigerator 28-z PLT is controlled, and therefore the low-temperature refrigeration function of the z PLT blood active ingredient refrigerator 28-z PLT on the platelet components therein is realized.
5) After the platelet component in the centrifuge cup has completely flowed out, the valve of the quick connector 07a, the valve of the quick connector 08a and the second centrifugal pump 09 are re-opened, and the centrifugation of the blood is restarted through the second pipeline 08, and the sharing and the cryopreservation of the red blood cells and the platelets are repeated.
6) Quick resurrection of active ingredient
When the red blood cell component which is frozen and stored at the low temperature of the blood active component refrigerator 28-z RBC in the z RBC (wherein z RBC is more than or equal to 1 and less than or equal to x RBC≤zRBC≤yRBC and less than or equal to m) needs to be output to the refrigerating equipment for another use, the rapid joint of the 28-z RBC refrigerator is opened, the output valve of the 28-z RBC is opened, the seventh centrifugal pump 38 is opened, and the red blood cell component stored in the blood active component refrigerator 28-z RBC in the z RBC enters the blood active component flow passage in the external membrane lung device 33 through the z RBC output pipeline 29-z RBC and the upper total output pipeline 29b under the action of the seventh centrifugal pump 38;
Further, warm water flows into the water bath circulation pipeline in the extracorporeal membrane lung device 33 from the outside of the device through the warm water input pipeline 34, flows in a spiral manner in the same direction as the red blood cell components in the blood effective component circulation pipeline, in the process, the warm water in the water bath circulation pipeline and the red blood cell components in the blood effective component circulation pipeline are subjected to heat exchange, the low-temperature red blood cell components are rewarmed so as to realize the recovery of the low-temperature frozen red blood cells, the warm water is converted into cold water due to heat release, and then the cold water subjected to heat exchange flows out of the water bath circulation pipeline in the extracorporeal membrane lung device 33 through the cold water output pipeline 36; simultaneously, an oxygen source outside the device generates oxygen, and the oxygen enters the blood effective component flow channel in the extracorporeal membrane lung device 33 through the oxygen transmission pipeline 35 and is uniformly mixed with the erythrocyte component, so that the oxygen carrying amount of the erythrocyte is increased; after passing through the extracorporeal membrane unit 33, the red blood cell component is output to the outside via the lower total output pipe 37 for use.
The technical features of the above embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, and various modifications and variations may be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (1)
1. A multi-functional blood recovery device, the multi-functional blood recovery device comprising:
the inferior vena cava blood flow collection end comprises a high-flux blood collection tube;
The blood active ingredient separation system comprises a blood storage tank, a five-way pipe, a normal saline cleaning device, a separation pump, a platelet storage tank and a plasma collection bag; the normal saline cleaning device comprises a normal saline storage tank and a flushing pipeline;
a donor blood purification system comprising a linear accelerator, a hemodialysis device, and a leukocyte filtration device;
The blood active ingredient collection system comprises a nitric oxide conveying device and a plurality of blood active ingredient refrigerators, wherein the blood active ingredient refrigerators are respectively communicated with the blood active ingredient separation system through a red blood cell recovery pipeline and a platelet recovery pipeline;
A cooling system;
A rapid resurrection device for blood active ingredients;
The blood collection device is characterized in that the inferior vena cava blood flow collection end is communicated with the blood storage tank through a first pipeline, the blood storage tank is communicated with the first end of the five-way pipe through a second pipeline, the second end of the five-way pipe is communicated with the flushing pipeline of the normal saline cleaning device, the third end of the five-way pipe is communicated with the red blood cell recovery pipeline, the fourth end of the five-way pipe is communicated with the separation pump through a two-way cover, and the fifth end of the five-way pipe is communicated with the platelet storage tank through a return pipeline; the anti-coagulation system is provided with an anti-coagulation storage tank, the anti-coagulation storage tank is communicated with the first pipeline through an anti-coagulation pipeline, and the anti-coagulation pipeline is connected between the inferior vena cava blood flow collection end and the blood storage tank; in the blood active ingredient separation system, a blood storage tank, a five-way valve separation pump, a platelet storage tank and a plasma collection bag are sequentially communicated, the two-way cover is arranged on a pump head of the separation pump and is communicated with a centrifugal cup of the separation pump, a first end of the two-way cover is communicated with a fourth end of the five-way pipe, a second end of the two-way cover is communicated with the platelet storage tank through a third pipeline, and the plasma collection bag is communicated with the platelet storage tank through a plasma collection pipeline; in the donor blood purification system, the linear accelerator is arranged on one side of the blood storage tank, and the radiation output end is opposite to the blood storage tank, so that free tumor cells remained in donor blood can be killed; the dialysis device and the leukocyte-filtering device are arranged on the second pipeline, wherein the hemodialysis device is arranged above the leukocyte-filtering device; in the blood active ingredient collection system, a first end of the red blood cell recovery pipeline is communicated with a third end of the five-way pipe, a second end of the red blood cell recovery pipeline is provided with a plurality of recovery branch pipes, and the recovery branch pipes are respectively communicated with a plurality of blood active ingredient refrigerators in a one-to-one correspondence manner; the first end of the platelet recovery pipeline is communicated with the platelet storage tank,
The second end of the platelet recovery pipeline is provided with a plurality of recovery branch pipes which are respectively communicated with the blood active ingredient refrigerators in a one-to-one correspondence manner; the nitric oxide conveying device comprises a nitric oxide storage tank, a gas throttle valve is arranged at an opening of the nitric oxide storage tank, the gas throttle valve is communicated with a first end of a gas conveying pipeline through a gas-tight joint, and a second end of the gas conveying pipeline is communicated with the red blood cell recovery pipeline through a gas valve; the cooling system comprises a compressor, a cooling fan and a condensation pipeline, wherein the compressor and the cooling fan are arranged in the areas near the plurality of blood active ingredient refrigerators; the plurality of condensation pipelines are arranged at the periphery of the plurality of blood active ingredient refrigerators in a one-to-one correspondence manner; the rapid resurrection device for the blood effective components comprises an outer membrane lung device, a plurality of blood effective component refrigerators are communicated with the outer membrane lung device through an upper total output pipeline, a water bath circulation pipeline and an effective component circulation pipeline are arranged in the outer membrane lung device, the water bath circulation pipeline and the effective component circulation pipeline are all spirally and parallelly arranged, warm water flowing through the water bath circulation pipeline exchanges heat with the blood effective components in the effective component circulation pipeline, and oxygen enters the blood effective component circulation pipeline through an oxygen delivery pipeline and is mixed with the blood effective components; still including centrifugal pump, choke valve, negative pressure suction source, quick-operation joint, at least part the pipeline is provided with centrifugal pump with the choke valve, the blood storage tank with the platelet storage tank be provided with respectively rather than jar chamber intercommunication the negative pressure suction source, pipeline and pipeline five-way valve, two-way cover, blood storage tank, platelet storage tank and the junction between the blood active ingredient fridge all are provided with quick-operation joint.
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| CA2207775A1 (en) * | 1995-01-13 | 1996-09-19 | Michael A. Mccarty | Method for facilitating autologous blood donation and treating oxygen debt |
| CA2220295A1 (en) * | 1995-06-07 | 1996-12-19 | Transfusion Technologies Corporation | Blood collection and separation system |
| CN114748503A (en) * | 2015-05-18 | 2022-07-15 | 希玛奈克斯特股份有限公司 | Method for storing whole blood and composition thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2624244T3 (en) * | 2009-12-22 | 2017-07-13 | Terumo Bct, Inc. | Methods and apparatus for collecting filtered blood components, in particular red blood cells |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2207775A1 (en) * | 1995-01-13 | 1996-09-19 | Michael A. Mccarty | Method for facilitating autologous blood donation and treating oxygen debt |
| CA2220295A1 (en) * | 1995-06-07 | 1996-12-19 | Transfusion Technologies Corporation | Blood collection and separation system |
| CN114748503A (en) * | 2015-05-18 | 2022-07-15 | 希玛奈克斯特股份有限公司 | Method for storing whole blood and composition thereof |
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|---|---|
| CN117695460A (en) | 2024-03-15 |
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