CN117679793A - Continuous flow type filtering equipment and method for drug intermediate - Google Patents
Continuous flow type filtering equipment and method for drug intermediate Download PDFInfo
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- CN117679793A CN117679793A CN202410134785.5A CN202410134785A CN117679793A CN 117679793 A CN117679793 A CN 117679793A CN 202410134785 A CN202410134785 A CN 202410134785A CN 117679793 A CN117679793 A CN 117679793A
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- 238000001914 filtration Methods 0.000 title claims abstract description 49
- 239000003814 drug Substances 0.000 title claims abstract description 23
- 229940079593 drug Drugs 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 title claims abstract description 15
- 239000007788 liquid Substances 0.000 claims abstract description 160
- 238000006073 displacement reaction Methods 0.000 claims abstract description 29
- 238000007790 scraping Methods 0.000 claims abstract description 22
- 238000009825 accumulation Methods 0.000 claims abstract description 20
- 239000000463 material Substances 0.000 claims abstract description 16
- 230000010355 oscillation Effects 0.000 claims abstract description 4
- 238000002347 injection Methods 0.000 claims description 20
- 239000007924 injection Substances 0.000 claims description 20
- 239000000543 intermediate Substances 0.000 claims description 19
- 238000002955 isolation Methods 0.000 claims description 10
- 239000012450 pharmaceutical intermediate Substances 0.000 claims description 9
- 239000011259 mixed solution Substances 0.000 claims description 5
- 238000011144 upstream manufacturing Methods 0.000 abstract description 5
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000011343 solid material Substances 0.000 description 11
- 238000012544 monitoring process Methods 0.000 description 3
- 238000004062 sedimentation Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Abstract
The invention discloses continuous flow type filtering equipment and method for a drug intermediate, and relates to the technical field of processing and treatment of the drug intermediate. In the invention, the following components are added: a material accumulation cavity is formed between the fixed table and the liquid inlet side plate, and the bottom of the material accumulation cavity is connected with a first output pipe. The upper side of the fixed table is slidingly provided with a squeezing flow plate, the horizontal height of the top end of the squeezing flow plate is lower than that of the top end of the liquid inlet side plate, and the horizontal height of the top end of the squeezing flow plate is higher than that of the top end of the liquid inlet side plate of the filtering tank at the downstream position. A displacement component for driving the squeeze flow plate to horizontally move is arranged above the filter tank, and a scraping oscillation area is formed between the scraping baffle and the top side surface of the fixed table. A buffer cavity is formed between the squeezing plate of the filter tank at the upstream position and the liquid inlet side plate of the filter tank at the downstream position. The invention avoids the filtration blockage in the traditional mode, can effectively remove most of liquid in the mixed liquid, and is beneficial to improving the subsequent processing and treatment process efficiency of the drug intermediate.
Description
Technical Field
The invention relates to the technical field of processing treatment of drug intermediates, in particular to continuous flow type filtering equipment and method for drug intermediates.
Background
When the mixed solution containing the solid molding drug intermediate is subjected to subsequent treatment, the solid material and the liquid of the drug intermediate are required to be separated, the existing separation is carried out by directly filtering through a filter screen, but the meshes of the filter screen are easy to be blocked, and the filter screen with some internal filtering structures is very troublesome to clean.
In addition, the solid material of the medicine intermediate filtered by the filter screen still needs to be subjected to links such as filter pressing and drying, and the mixed liquid with larger solid material concentration of the medicine intermediate can be effectively subjected to filter pressing and drying as long as most of liquid in the original solid-liquid mixture of the medicine intermediate is removed. Therefore, designing a device that can effectively remove most of the liquid in the mixed liquid without cleaning the filter plug is a problem to be solved.
Disclosure of Invention
The invention aims to solve the technical problem of providing continuous flow type filtering equipment and method for a drug intermediate, so that the filtering blockage in the traditional mode is avoided, most of liquid in mixed liquid can be effectively removed, and the subsequent processing and treatment process efficiency of the drug intermediate is improved.
In order to solve the technical problems, the invention is realized by the following technical scheme:
the invention provides a continuous flow type filtering device for a drug intermediate, which comprises a plurality of filtering ponds with sequentially reduced horizontal heights, wherein each filtering pond comprises a liquid inlet side plate, an injection pipe is inserted into the first filtering pond along the liquid inlet side plate, a fixed table is fixedly arranged on the inner side of the liquid inlet side plate of each filtering pond, a material accumulation cavity is formed between the fixed table and the liquid inlet side plate, the bottom of the material accumulation cavity is connected with a first output pipe, and the first output pipe is provided with a first valve. The upper side of the fixed table is slidingly provided with a squeezing flow plate, the horizontal height of the top end of the squeezing flow plate is lower than that of the top end of the liquid inlet side plate, and the horizontal height of the top end of the squeezing flow plate is higher than that of the top end of the liquid inlet side plate of the filtering tank at the downstream position. A displacement component for driving the squeezing flow plate to horizontally move is arranged above the filter tank, a scraping baffle plate which is inclined downwards is fixedly arranged on one side surface of the squeezing flow plate, which faces the liquid inlet side plate, and a scraping oscillation area is formed between the scraping baffle plate and the top side surface of the fixed table.
The liquid inlet side plate of the filter tank is embedded with a first photoelectric sensor and a second photoelectric sensor, wherein the second photoelectric sensor is positioned below the first photoelectric sensor, and the second photoelectric sensor is right opposite to the accumulation cavity. The liquid level sensor is embedded at the top of one side face of the squeezing flow plate, which faces the liquid inlet side plate, and the third photoelectric sensor which is vertically upwards detected is embedded at the top of the squeezing flow plate. A buffer cavity is formed between the squeezing plate of the filter tank at the upstream position and the liquid inlet side plate of the filter tank at the downstream position, a fourth photoelectric sensor facing the buffer cavity at the upstream side is embedded in the liquid inlet side plate of the filter tank at the downstream side, a second output pipe is connected to the bottom of the buffer cavity, and a second valve is configured on the second output pipe.
As a preferred technical scheme of the filtering device of the invention: an injection isolation cover is arranged in the filter tank, an outlet at the lower end of the injection pipe is inserted into the injection isolation cover, a liquid outlet facing the accumulation cavity is formed in the bottom side of the injection isolation cover, and the horizontal height of the lowest end of the scraping baffle is lower than that of the liquid outlet.
As a preferred technical scheme of the filtering device of the invention: the displacement assembly comprises a guide rod positioned above the filter tank, the guide rod is provided with a linear motor, and a pushing hack lever is fixedly connected between the linear motor and the squeezing flow plate.
As a preferred technical scheme of the filtering device of the invention: the lower side end of the squeezing flow plate is provided with a scraping strip which is in squeezing contact with the top side surface of the fixed table.
As a preferred technical scheme of the filtering device of the invention: the upper side port of the second output pipe is adjacent to the liquid inlet side plate of the filtering tank at the downstream position.
The invention provides a continuous flow type filtering method for a drug intermediate, which comprises the following steps:
s1, injecting the mixed liquid of the drug intermediate into the filter tank through the injection pipe, and stopping injecting the mixed liquid when the liquid level sensor senses a liquid level signal.
S2, a first photoelectric sensor senses that the turbidity of liquid is smaller than a first reference value phi preset by a system 1 When the displacement assembly is started,the squeezing flow plate is driven to start to move at a constant speed towards the direction of the liquid inlet side plate of the current filter tank.
S3, liquid in the filter tank flows into the buffer cavity from the top side of the squeezing flow plate, and a third photoelectric sensor on the top side of the squeezing flow plate monitors the turbidity of the liquid in real time: (1) If the liquid turbidity is smaller than the first reference value phi preset by the system 1 When the displacement assembly continuously drives the squeezing flow plate to move at a constant speed towards the direction of the liquid inlet side plate of the current filter tank; (2) If the turbidity of the liquid is not lower than a first reference value phi preset by the system 1 When the displacement assembly stops driving the squeezing plate, the first photoelectric sensor continues t 1 The duration monitors that the turbidity of the liquid is smaller than a first reference value phi preset by the system 1 And then, the displacement assembly continuously drives the squeezing flow plate to move at a constant speed towards the direction of the liquid inlet side plate of the current filter tank.
S4, stopping advancing when the squeeze flow plate reaches the edge position of one side of the fixed table, close to the liquid inlet side plate, and standing the liquid in the buffer cavity for t 2 After the time, the displacement assembly starts to drive the squeezing flow plate to move at a constant speed towards the liquid inlet side plate of the filter tank at the downstream position: (1) If the first photoelectric sensor in the filter tank at the adjacent downstream position detects that the liquid turbidity is smaller than a first reference value phi preset by the system 1 When the displacement assembly continuously drives the squeezing flow plate to move at a constant speed towards the liquid inlet side plate of the filtering tank at the downstream position; (2) If the first photoelectric sensor in the filter tank at the adjacent downstream position detects that the liquid turbidity is not lower than a first reference value phi preset by the system 1 When the displacement assembly stops driving the squeeze plate, interval t 2 After the time, the displacement assembly continuously drives the squeezing flow plate to move at a constant speed towards the liquid inlet side plate of the filter tank at the downstream position.
S5, when the second photoelectric sensor senses that the turbidity of the liquid is not lower than a second reference value phi preset by the system 2 When the first valve is opened, the first output pipe outputs the mixed liquid in the accumulation cavity.
S6, when the fourth photoelectric sensor senses that the turbidity of the liquid is not lower than a second reference value phi preset by the system 2 And when the second valve is opened, the second output pipe outputs the mixed liquid in the buffer cavity.
In the present invention, the flow throughIn the filtering method, t 1 Duration, t 2 The duration is the interval time preset by the system, t 1 The duration is not less than 1min, t 2 The duration is not less than 3min.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, the continuous ladder-shaped distributed filter tanks are designed, the fixed table is designed in the filter tanks, the squeezing flow plates are arranged on the upper sides of the fixed table, the squeezing flow plates are driven to advance and retreat through monitoring the solid material sedimentation state of the medicine intermediates in the filter tanks, the high-turbidity liquid areas are respectively subjected to 'drainage', the mixed liquid discharged into the buffer cavity is subjected to solid material sedimentation again, clear liquid is discharged, and meanwhile the 'sedimentation' mixed liquid conforming to the solid material concentration is accurately discharged, so that the filtering blockage in the traditional mode is avoided, most of liquid in the mixed liquid is effectively removed, and the subsequent processing and treatment process efficiency of the medicine intermediates is improved.
Drawings
FIG. 1 is an overall schematic of a continuous flow filtration device for pharmaceutical intermediates of the present invention.
FIG. 2 is a schematic illustration of a single filtration tank in accordance with the present invention.
FIG. 3 is a schematic view of the initial position of the squeeze plate of the filtering apparatus of the present invention.
Wherein: 1-a filter tank, 101-a liquid inlet side plate; 2-an injection tube; 3-injecting an isolation cover and 301-discharging a liquid; 4-a fixed table; 5-a squeeze plate; 6, scraping a baffle; 7, scraping strips; 8-a guide rod; 9-a linear motor; 10-pushing the hack lever; 11-a liquid level sensor; 12-a first photosensor; 13-a material accumulation cavity; 14-a second photosensor; 15-a third photosensor; 16-a cache chamber; 17-scraping oscillation area; 18-fourth photosensors; 19-a first output tube; 20-a first valve; 21-a second output tube; 22-second valve.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
The first embodiment of the invention relates to a continuous flow type filtering device for a drug intermediate, which has the following main structure and mutual matching modes:
referring to fig. 1, a plurality of filtering ponds 1 are distributed in a ladder shape, the horizontal heights of the filtering ponds 1 are reduced in sequence, a liquid inlet side plate 101 is arranged on the liquid inlet side of the filtering ponds 1, an injection pipe 2 is inserted into a first filtering pond 1 along the liquid inlet side plate 101, an injection isolation cover 3 is arranged in the first filtering pond 1, and the outlet at the lower end of the injection pipe 2 is inserted into the injection isolation cover 3.
The inner side of the liquid inlet side plate 101 of each filter tank 1 is fixedly provided with a fixed table 4, a material accumulation cavity 13 is formed between the fixed table 4 and the liquid inlet side plate 101, a liquid outlet 301 facing the material accumulation cavity 13 is formed in the bottom side of the injection isolation cover 3, a first output pipe 19 is connected to the bottom of the material accumulation cavity 13, and a first valve 20 controls the on-off of the first output pipe 19.
The squeezing flow plate 5 is slidably mounted on the upper side of the fixed table 4, the top end of the squeezing flow plate 5 is lower than the top end of the liquid inlet side plate 101, and the top end of the squeezing flow plate 5 is higher than the top end of the liquid inlet side plate 101 of the filter tank 1 at the downstream position.
In addition, in the moving process of the squeezing flow plate 5, a buffer cavity 16 is formed between the squeezing flow plate 5 of the filter tank 1 at the upstream position and the liquid inlet side plate 101 of the filter tank 1 at the downstream position. The second output pipe 21 is connected at the bottom of the buffer cavity 16, the second valve 22 controls the on-off of the second output pipe 21, the upper side port of the second output pipe 21 is adjacent to the liquid inlet side plate 101 of the filter tank 1 at the downstream position, when the squeezing flow plate 5 faces the liquid inlet side plate 101 of the filter tank 1 at the downstream position, the mixed liquid with turbidity exceeding the standard at the bottom of the buffer cavity 16 can be continuously discharged until the squeezing flow plate 5 is close to the liquid inlet side plate 101 of the filter tank 1 at the downstream position.
Referring to fig. 2, a guide rod 8 is disposed above each filtering tank 1, a linear motor 9 moves on the guide rod 8 in a directional manner, a pushing frame rod 10 is fixedly connected below the linear motor 9, the pushing frame rod 10 is fixedly connected with the squeezing flow plate 5, the linear motor 9 moves, and the squeezing flow plate 5 is pushed to move horizontally by the pushing frame rod 10.
The crowded strip 7 of scraping that is equipped with of board 5 downside, scrape strip 7 and the top side extrusion contact of fixed station 4, crowded board 5 has set up and has scraped material baffle 6, scrapes a side of material baffle 6 towards feed liquor curb plate 101, scrapes the downward setting of material baffle 6 slope, scrapes material and shakes the region 17 and is located the region of scraping between material baffle 6 and the top side of fixed station 4, scrapes material and shakes region 17: in fact, during the movement process of the extruding and flowing plate 5, some solid materials which are originally deposited on the top side surface of the fixed table 4 can be extruded and scraped, after the solid materials are scraped, the liquid flow moves, the scraping baffle 6 limits the escape of the scraped solid materials from the upper part, the solid materials move randomly in a narrow area like 'shake', in addition, the horizontal height of the lowest end of the scraping baffle 6 is lower than the horizontal height of the liquid outlet 301, so that the scraping baffle 6 can push forwards farther, and the scraped solid materials in the scraping shake area 17 enter the accumulation cavity 13.
The liquid inlet side plate 101 of the filter tank 1 is embedded with a first photoelectric sensor 12, and the first photoelectric sensor 12 is used for sensing and monitoring the turbidity condition of liquid at the upper part of the filter tank 1. The liquid inlet side plate 101 of the filter tank 1 is also embedded with a second photoelectric sensor 14, the second photoelectric sensor 14 is positioned below the first photoelectric sensor 12, the second photoelectric sensor 14 is opposite to the accumulation cavity 13, and the second photoelectric sensor 14 is used for sensing and monitoring the turbidity condition of liquid in the accumulation cavity 13.
The liquid level sensor 11 is embedded at the top position of the squeezing plate 5 facing one side surface of the liquid inlet side plate 101, and after the liquid level sensor 11 detects the liquid level, the liquid level in the filtering tank is about to be full. The reason why the liquid level sensor 11 is disposed on the side of the squeeze plate 5 is that, except for the liquid inlet side plate 101 of the first filtering tank 1, when the liquid flows in, the liquid continuously flows from the wall surface of the liquid inlet side plate 101 to the top down, and if the liquid level sensor 11 is disposed on the liquid inlet side plate 101, erroneous judgment may be caused. In addition, the top of the squeeze plate 5 is embedded with a third photoelectric sensor 15 which detects vertically upwards, monitors the turbidity of the liquid flowing through, and the liquid inlet side plate 101 of the downstream side filter tank 1 is embedded with a fourth photoelectric sensor 18 which faces the upstream side buffer cavity 16, and monitors the turbidity of the liquid in the buffer cavity 16.
Referring to fig. 1 and 3, fig. 3 is a schematic diagram of the present invention in which the squeezing plate 5 is at an initial position, and the linear motor 9 drives the squeezing plate 5 to move transversely along the top side of the fixed table 4, so as to continuously switch the operation of "draining" the liquid in the filtering tank 1 and the buffer cavity 16.
The second embodiment of the invention relates to a continuous flow type filtering method for a drug intermediate, which comprises the following steps:
firstly, a drug intermediate mixed solution is injected into a filter tank 1 through an injection pipe 2, when a liquid level sensor 11 senses a liquid level signal, the injection of the mixed solution is stopped, and a first photoelectric sensor 12 senses that the turbidity of the liquid is smaller than a first reference value phi preset by a system 1 When the liquid inlet side plate 101 of the current filter tank 1 is in a constant speed movement, the displacement assembly is started to drive the squeezing flow plate 5 to start moving towards the liquid inlet side plate 101 of the current filter tank 1.
Secondly, the liquid in the filter tank 1 flows into the buffer cavity 16 from the top side of the squeezing flow plate 5, and the third photoelectric sensor 15 on the top side of the squeezing flow plate 5 monitors the turbidity of the liquid in real time:
case one: if the liquid turbidity is smaller than the first reference value phi preset by the system 1 When the liquid-feeding side plate 101 of the current filter tank 1 is in a constant speed, the displacement assembly continuously drives the squeezing flow plate 5 to move towards the liquid-feeding side plate 101.
And a second case: if the turbidity of the liquid is not lower than a first reference value phi preset by the system 1 When the displacement component stops driving the squeeze plate 5, the first photoelectric sensor 12 continues t 1 The duration monitors that the turbidity of the liquid is smaller than a first reference value phi preset by the system 1 And then, the displacement assembly continuously drives the squeezing flow plate 5 to move at a constant speed towards the direction of the liquid inlet side plate 101 of the current filter tank 1.
Thirdly, stopping the advance when the squeeze plate 5 reaches the edge position of the fixed table 4 close to one side of the liquid inlet side plate 101, and standing the liquid in the buffer cavity 16 at t 2 After a period of time (t) 1 The duration is the interval time preset by the system, t 1 The duration is not less than 1 min), the displacement assembly starts to drive the squeeze plate 5 to move at a constant speed towards the liquid inlet side plate 101 of the filter tank 1 at the downstream position:
case one: if the first photoelectric sensor 12 in the filter tank at the adjacent downstream position detects that the liquid turbidity is smaller than the first reference value phi preset by the system 1 When the displacement assembly continues to drive the squeeze plate 5 to faceThe filter tank 1 moves at a constant speed in the direction of the liquid inlet side plate 101 at the downstream position.
And a second case: if the first photoelectric sensor 12 in the filter tank 1 at the adjacent downstream position detects that the liquid turbidity is not lower than a first reference value phi preset by the system 1 When the displacement assembly stops driving the squeeze plate 5, interval t 2 After a period of time (t) 2 The duration is the interval time preset by the system, t 2 The duration is not less than 3 min), the displacement component continuously drives the squeezing flow plate 5 to move at a constant speed towards the liquid inlet side plate 101 of the filter tank 1 at the downstream position.
Fourth, when the second photoelectric sensor 14 senses that the turbidity of the liquid is not lower than the second reference value phi preset by the system 2 When the first valve 20 is opened, the first output pipe 19 outputs the mixed liquid in the accumulation cavity 13, and when the first output pipe 19 outputs the mixed liquid, the normal movement of the squeeze plate 5 is not influenced, so long as the liquid level sensor 11 senses that the liquid level is enough and the related requirements in the second step are met.
Fifth, when the fourth photoelectric sensor 18 senses that the turbidity of the liquid is not lower than the second reference value phi preset by the system 2 When the second valve 22 is opened, the second output pipe 21 outputs the mixed liquid in the buffer chamber 16. The second output pipe 21 does not influence the normal movement of the squeeze plate 5 when outputting, and is irrelevant to the current liquid level of the filter tank 1, so long as the relevant requirement in the third step is met.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the invention.
Claims (7)
1. A pharmaceutical intermediate continuous flow filtration device characterized by:
the filter tank comprises a plurality of filter tanks (1) with sequentially reduced horizontal heights, wherein each filter tank (1) comprises a liquid inlet side plate (101), an injection pipe (2) is inserted into each filter tank (1) along each liquid inlet side plate (101), a fixed table (4) is fixedly arranged on the inner side of each liquid inlet side plate (101) of each filter tank (1), a material accumulation cavity (13) is formed between each fixed table (4) and each liquid inlet side plate (101), a first output pipe (19) is connected to the bottom of each material accumulation cavity (13), and a first valve (20) is arranged on each first output pipe (19);
the upper side of the fixed table (4) is slidingly provided with a squeezing flow plate (5), the horizontal height of the top end of the squeezing flow plate (5) is lower than that of the top end of the liquid inlet side plate (101), and the horizontal height of the top end of the squeezing flow plate (5) is higher than that of the top end of the liquid inlet side plate (101) of the filtering pond (1) at the downstream position;
a displacement assembly for driving the squeeze flow plate (5) to horizontally move is arranged above the filter tank (1), a scraping baffle (6) which is inclined downwards is fixedly arranged on one side surface of the squeeze flow plate (5) facing the liquid inlet side plate (101), and a scraping oscillation area (17) is formed between the scraping baffle (6) and the top side surface of the fixed table (4);
a first photoelectric sensor (12) and a second photoelectric sensor (14) are embedded in a liquid inlet side plate (101) of the filter tank (1), wherein the second photoelectric sensor (14) is positioned below the first photoelectric sensor (12), and the second photoelectric sensor (14) is opposite to the accumulation cavity (13);
a liquid level sensor (11) is embedded at the top of one side surface of the squeezing flow plate (5) facing the liquid inlet side plate (101), and a third photoelectric sensor (15) for detecting vertically upwards is embedded at the top of the squeezing flow plate (5);
a buffer cavity (16) is formed between the squeezing flow plate (5) of the upstream-position filter tank (1) and the liquid inlet side plate (101) of the downstream-position filter tank (1), a fourth photoelectric sensor (18) facing the upstream-side buffer cavity (16) is embedded in the liquid inlet side plate (101) of the downstream-side filter tank (1), a second output pipe (21) is connected to the bottom of the buffer cavity (16), and a second valve (22) is arranged on the second output pipe (21).
2. A pharmaceutical intermediate continuous flow filtration device according to claim 1, wherein:
an injection isolation cover (3) is arranged in the filter tank (1), an outlet at the lower end of the injection pipe (2) is inserted into the injection isolation cover (3), and a liquid outlet (301) facing the accumulation cavity (13) is formed in the bottom side of the injection isolation cover (3);
the horizontal height of the lowest end of the scraping baffle plate (6) is lower than that of the liquid outlet (301).
3. A pharmaceutical intermediate continuous flow filtration device according to claim 1, wherein:
the displacement assembly comprises a guide rod (8) positioned above the filter tank (1), the guide rod (8) is provided with a linear motor (9), and a pushing rack rod (10) is fixedly connected between the linear motor (9) and the squeezing flow plate (5).
4. A pharmaceutical intermediate continuous flow filtration device according to claim 1, wherein:
the lower side end of the squeezing flow plate (5) is provided with a scraping strip (7), and the scraping strip (7) is in squeezing contact with the top side surface of the fixed table (4).
5. A pharmaceutical intermediate continuous flow filtration device according to claim 1, wherein:
the upper side port of the second output pipe (21) is adjacent to the liquid inlet side plate (101) of the filter tank (1) at the downstream position.
6. A process for continuous flow filtration of pharmaceutical intermediates, characterized in that a pharmaceutical intermediate continuous flow filtration device according to any one of claims 1 to 5 is used, comprising the following steps:
s1, injecting a drug intermediate mixed solution into a filter tank (1) through an injection pipe (2), and stopping injecting the mixed solution when a liquid level signal is sensed by a liquid level sensor (11);
s2, a first photoelectric sensor (12) senses that the turbidity of the liquid is smaller than a first reference value phi preset by a system 1 When the displacement assembly is started, driveThe squeezing flow plate (5) starts to move at a constant speed towards the direction of the liquid inlet side plate (101) of the current filter tank (1);
s3, liquid in the filter tank (1) flows into the buffer cavity (16) from the top side of the squeezing flow plate (5), and a third photoelectric sensor (15) on the top side of the squeezing flow plate (5) monitors the turbidity of the liquid in real time:
if the liquid turbidity is smaller than the first reference value phi preset by the system 1 When the liquid inlet side plate (101) of the current filter tank (1) is in constant speed movement, the displacement assembly continuously drives the squeezing flow plate (5);
if the turbidity of the liquid is not lower than a first reference value phi preset by the system 1 When the displacement component stops driving the extruding plate (5), the first photoelectric sensor (12) continues t 1 The duration monitors that the turbidity of the liquid is smaller than a first reference value phi preset by the system 1 Then, the displacement assembly continuously drives the squeezing flow plate (5) to move at a constant speed towards the direction of the liquid inlet side plate (101) of the current filter tank (1);
s4, stopping advancing when the squeezing flow plate (5) reaches the edge position of the fixed table (4) close to one side of the liquid inlet side plate (101), and standing the liquid in the buffer cavity (16) at t 2 After the duration, the displacement assembly starts to drive the squeezing flow plate (5) to move at a constant speed towards the liquid inlet side plate (101) of the filter tank (1) at the downstream position:
if a first photoelectric sensor (12) in the filter tank at the adjacent downstream position detects that the liquid turbidity is smaller than a first reference value phi preset by the system 1 When the displacement assembly continuously drives the squeezing flow plate (5) to move at a constant speed towards the liquid inlet side plate (101) of the filter tank (1) at the downstream position;
if the first photoelectric sensor (12) in the filter tank (1) at the adjacent downstream position detects that the liquid turbidity is not lower than a first reference value phi preset by the system 1 When the displacement component stops driving the squeeze plate (5), the interval t 2 After the duration, the displacement assembly continuously drives the squeezing flow plate (5) to move at a constant speed towards the liquid inlet side plate (101) of the filtering pond (1) at the downstream position;
s5, when the second photoelectric sensor (14) senses that the turbidity of the liquid is not lower than a second reference value phi preset by the system 2 When the first valve (20) is opened, the first output pipe (19) outputs the mixed liquid in the accumulation cavity (13);
s6, when the fourth photoelectric sensor (18) senses that the turbidity of the liquid is not lower than a second reference value phi preset by the system 2 When the second valve (22) is opened, the second output pipe (21) outputs the mixed liquid in the buffer cavity (16).
7. A process for continuous flow filtration of a pharmaceutical intermediate according to claim 6, wherein:
t 1 duration, t 2 The duration is the interval time preset by the system, t 1 The duration is not less than 1min, t 2 The duration is not less than 3min.
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| KR102034148B1 (en) * | 2019-06-10 | 2019-10-18 | 효림산업주식회사 | Deep-bed Sludge collector including coagulation & concentration and high turbidity wastewater treatment system containing the same |
| CN111068402A (en) * | 2019-12-20 | 2020-04-28 | 仇爽 | Movable sand washing system |
| CN215538661U (en) * | 2021-08-20 | 2022-01-18 | 郝思佳 | Horizontal flow sedimentation tank |
| CN116813136A (en) * | 2022-04-22 | 2023-09-29 | 倍杰特集团股份有限公司 | Water recovery system and method for extracting high-concentration crystalline salt from coking wastewater |
| CN117142605A (en) * | 2023-09-27 | 2023-12-01 | 内蒙古包钢集团环境工程研究院有限公司 | High-efficient clarification tank |
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