CN117678599B - Hypochlorous acid disinfectant with improved stability and sterilization effect and preparation method thereof - Google Patents
Hypochlorous acid disinfectant with improved stability and sterilization effect and preparation method thereof Download PDFInfo
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- CN117678599B CN117678599B CN202410147583.4A CN202410147583A CN117678599B CN 117678599 B CN117678599 B CN 117678599B CN 202410147583 A CN202410147583 A CN 202410147583A CN 117678599 B CN117678599 B CN 117678599B
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- disinfectant
- hypochlorous acid
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 42
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 30
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 11
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 230000000694 effects Effects 0.000 title claims description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 239000003381 stabilizer Substances 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000008213 purified water Substances 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims description 16
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 7
- 239000000460 chlorine Substances 0.000 claims description 7
- 229910052801 chlorine Inorganic materials 0.000 claims description 7
- BQTOJCOSKKLTAB-UHFFFAOYSA-L [Na+].O1P(OC1CO)(=O)OP(=O)([O-])[O-].[Na+] Chemical compound [Na+].O1P(OC1CO)(=O)OP(=O)([O-])[O-].[Na+] BQTOJCOSKKLTAB-UHFFFAOYSA-L 0.000 claims description 6
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 claims description 6
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 6
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 6
- 239000012747 synergistic agent Substances 0.000 claims description 5
- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- 150000007524 organic acids Chemical class 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 4
- 239000010452 phosphate Substances 0.000 claims description 4
- 239000005643 Pelargonic acid Substances 0.000 claims description 3
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 3
- ZFSLODLOARCGLH-UHFFFAOYSA-N isocyanuric acid Chemical compound OC1=NC(O)=NC(O)=N1 ZFSLODLOARCGLH-UHFFFAOYSA-N 0.000 claims description 3
- 229960001774 octenidine Drugs 0.000 claims description 3
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 claims description 3
- ICCOTNFOZNKKAD-UHFFFAOYSA-M sodium 2-oxido-2-oxo-1,3,2lambda5-dioxaphosphinan-4-amine Chemical compound P1(=O)(OC(CCO1)N)[O-].[Na+] ICCOTNFOZNKKAD-UHFFFAOYSA-M 0.000 claims description 3
- 229940005605 valeric acid Drugs 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- 239000001488 sodium phosphate Substances 0.000 claims description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 2
- 235000011008 sodium phosphates Nutrition 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 abstract description 5
- 241000222122 Candida albicans Species 0.000 abstract description 3
- 241000588724 Escherichia coli Species 0.000 abstract description 3
- 229940095731 candida albicans Drugs 0.000 abstract description 3
- 230000002147 killing effect Effects 0.000 abstract description 3
- 241000228245 Aspergillus niger Species 0.000 abstract description 2
- 244000063299 Bacillus subtilis Species 0.000 abstract description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 abstract description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
- 230000002035 prolonged effect Effects 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 13
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 4
- 230000009467 reduction Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- QDWYPRSFEZRKDK-UHFFFAOYSA-M sodium;sulfamate Chemical compound [Na+].NS([O-])(=O)=O QDWYPRSFEZRKDK-UHFFFAOYSA-M 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Microbiology (AREA)
- Inorganic Chemistry (AREA)
Abstract
The invention discloses hypochlorous acid disinfectant for improving stability and sterilizing effect and a preparation method thereof, which belong to the technical field of antibacterial disinfection and are prepared from the following raw materials in percentage by weight: 0.02% -0.1% of calcium hypochlorite; stabilizing agent: 0.025% -0.12%; synergists: 0.01% -0.05%; ethylene glycol: 0.05% -0.1%; pH regulator: 0.002% -0.005%; purified water makes up 100%. The hypochlorous acid disinfectant provided by the invention effectively improves the concentration and stability of hypochlorous acid in the disinfectant, and each active ingredient is fully dissolved and dispersed in the disinfectant, so that the sterilizing effect of the product is improved, and the storage time is prolonged. The effective components in the disinfectant can easily penetrate into the interior of the thallus to cause the death of bacteria, and has obvious killing effect on candida albicans, escherichia coli, pseudomonas aeruginosa, aspergillus niger, bacillus subtilis black variant spore and the like.
Description
Technical Field
The invention relates to hypochlorous acid disinfectant with improved stability and sterilization effect and a preparation method thereof, and belongs to the technical field of antibacterial disinfection.
Background
The hypochlorous acid disinfectant has the characteristics of high efficiency, no residual pollution and the like, dynamic balance of HClO, cl < - >, clO < - >, hypochlorite and hypochlorous acid exist in the hypochlorous acid solution, and the sterilizing principles of the hypochlorous acid disinfectant are completely different. The cell membrane surface is negatively charged, so hypochlorite cannot easily enter the inside of the cell, while hypochlorous acid is a neutral small molecule, and can penetrate into the surface of the negatively charged cell body through the cell wall to cause death of bacteria. In addition, hypochlorous acid is decomposed faster under the condition of being heated or being catalyzed by metal ions. Therefore, the traditional hypochlorous acid disinfectant has good sterilization effect, but has poor stability, is greatly influenced by environment and has short preservation time.
In order to improve the stability, a stabilizer is generally added into the hypochlorous acid disinfectant to improve the stability of the disinfectant, and the common sulfamic acid and sodium sulfamate stabilizers can improve the stability of the hypochlorous acid disinfectant, but greatly reduce the sterilizing effect of the hypochlorous acid.
The foregoing is not necessarily a prior art, and falls within the technical scope of the inventors.
Disclosure of Invention
The invention provides hypochlorous acid disinfectant with improved stability and sterilization effect and a preparation method thereof, aiming at solving the problems existing in the prior art.
The invention realizes the aim by adopting the following technical scheme:
a hypochlorous acid disinfectant for improving stability and sterilization effect is prepared from the following raw materials in percentage by weight:
0.02% -0.1% of calcium hypochlorite;
stabilizing agent: 0.025% -0.12%;
synergists: 0.01% -0.05%;
ethylene glycol: 0.05% -0.1%;
pH regulator: 0.002% -0.005%;
purified water makes up 100%;
the stabilizer consists of organic phosphate and cyanuric acid with the weight ratio of (10-14) being 1, wherein the organic phosphate is selected from any one or more of sodium aminotrimethylene phosphate, disodium hydroxyethylidene diphosphate and sodium hydroxyethylidene diphosphate.
Preferably, the synergistic agent consists of (10-13) organic acid and octenidine in a weight ratio of (1), wherein the organic acid adopts one or more of pelargonic acid, octanoic acid and valeric acid.
Preferably, the pH regulator is one or more of HCl, sodium phosphate, disodium hydrogen phosphate or sodium dihydrogen phosphate.
The preparation method of the hypochlorous acid disinfectant for improving stability and sterilizing effect provided by the invention comprises the following steps:
(1) Adding purified water into calcium hypochlorite to dilute until the effective chlorine concentration is 50-150 ppm, fully stirring for 1-1.5h, and filtering;
(2) Adding a stabilizing agent into the filtered solution, heating and stirring in a constant-temperature water bath at 37 ℃ for 2-2.5h, wherein the stirring speed is 150-200r/min;
(3) Adding glycol and stirring uniformly;
(4) Adding a synergistic agent and uniformly stirring;
(5) And adding a pH regulator to regulate the pH of the solution to 5-7, thus obtaining the hypochlorous acid disinfectant with improved stability and sterilization effect.
Benefits of the present application include, but are not limited to:
according to the hypochlorous acid disinfectant provided by the invention, cyanuric acid and sodium aminotrimethylene phosphate, disodium hydroxyethylidene diphosphate or sodium hydroxyethylidene diphosphate are used as stabilizers, octenidine and pelargonic acid, octanoic acid or valeric acid are used as synergists, the pH value of the disinfectant is reasonably regulated, the concentration and stability of hypochlorous acid in the disinfectant are effectively improved, and each active ingredient is fully dissolved and dispersed in the disinfectant, so that the sterilizing and disinfecting effects of the product are improved, and the storage time is prolonged. The effective components in the disinfectant can easily penetrate into the interior of the thallus to cause the death of bacteria, and has obvious killing effect on candida albicans, escherichia coli, pseudomonas aeruginosa, aspergillus niger, bacillus subtilis black variant spore and the like.
Detailed Description
The present invention will be described in further detail in the following. It should be noted, however, that the following detailed description presents specific examples of the invention by way of illustration only, and the scope of the invention is not limited thereto. The scope of the invention is limited only by the claims. It will be obvious to those skilled in the art that various other modifications and substitutions can be made to the described embodiments of the invention within the scope of the invention as defined by the appended claims, and the same technical effects can still be achieved, achieving the final technical purpose of the invention.
Unless otherwise indicated, the starting materials in this specification are commercially available.
Example 1:
the hypochlorous acid disinfectant for improving stability and sterilizing effect provided in this example is prepared from the raw materials in table 1:
TABLE 1
Example 2:
the hypochlorous acid disinfectant for improving stability and sterilizing effect provided in this example is prepared from the raw materials in table 2:
TABLE 2
Example 3:
the hypochlorous acid disinfectant for improving stability and sterilizing effect provided in this example is prepared from the raw materials in table 3:
TABLE 3 Table 3
Example 4:
the hypochlorous acid disinfectant for improving stability and sterilizing effect provided in this example is prepared from the raw materials in table 4:
TABLE 4 Table 4
The preparation method of hypochlorous acid disinfectant for improving stability and sterilizing effect provided in examples 1-4 comprises the following steps:
(1) Adding purified water into calcium hypochlorite to dilute until the effective chlorine concentration is 50-150 ppm, fully stirring for 1-1.5h, and filtering;
(2) Adding a stabilizing agent into the filtered solution, heating and stirring in a constant-temperature water bath at 37 ℃ for 2-2.5h, wherein the stirring speed is 150-200r/min;
(3) Adding glycol and stirring uniformly;
(4) Adding a synergistic agent and uniformly stirring;
(5) And adding a pH regulator to regulate the pH of the solution to 5-7, thus obtaining the hypochlorous acid disinfectant with improved stability and sterilization effect.
Comparative example 1:
the disinfectant provided in this comparative example is prepared from the raw materials in table 5:
TABLE 5
Comparative example 2:
the disinfectant provided in this comparative example is prepared from the raw materials in table 6:
TABLE 6
Comparative example 3:
the disinfectant provided in this comparative example is prepared from the raw materials in table 7:
TABLE 7
Comparative example 4:
the disinfectant provided in this comparative example is prepared from the raw materials in table 8:
TABLE 8
The preparation method of the disinfectant provided in comparative examples 1-4 comprises the following steps: mixing the above materials, and stirring.
The national standard GB/T36758-2018 prescribes that the effective chlorine reduction rate must not exceed 10% in the effective period of the product, the effective chlorine content of the liquid chlorine-containing disinfectant must not be lower than the lower limit of the marked value, and the effective period of the product must not be less than 6 months. The reduction rate of the sterilizing effective components is less than or equal to 10 percent after the sterilizing effective components are stored for 14 days at 54 ℃ and is equal to one year of the effective period (2002 edition of sterilizing technical specification), and the process of a degradation test can be accelerated by using a 54 ℃ incubator.
The disinfectant provided in each example and comparative example of the present invention was stored at 54℃for 14 days, and the detection results of available chlorine are shown in Table 9.
TABLE 9 effective chlorine reduction Rate
It can be seen that the disinfectant provided by the invention meets the requirements on stability and is superior to that of comparative examples 1-3.
The sterilizing effect (action time 3 min) of the sterilizing liquid provided for each example and comparative example on test bacteria according to the "sterilizing technical Specification" of Ministry of health (2002 edition) is shown in Table 10 below.
TABLE 10 results of sterilizing fluids on various bacteria
The disinfectant provided by the invention has obvious killing effect on candida albicans, escherichia coli and the like. In contrast, the disinfectant provided in comparative example 4 has high stability, but the sterilizing effect is not satisfactory.
The above embodiments are not to be taken as limiting the scope of the invention, and any alternatives or modifications to the embodiments of the invention will be apparent to those skilled in the art and fall within the scope of the invention.
The present invention is not described in detail in the present application, and is well known to those skilled in the art.
Claims (1)
1. The hypochlorous acid disinfectant for improving stability and sterilizing effect is characterized by being prepared from the following raw materials in percentage by weight:
0.02% -0.1% of calcium hypochlorite;
stabilizing agent: 0.025% -0.12%;
synergists: 0.01% -0.05%;
ethylene glycol: 0.05% -0.1%;
pH regulator: 0.002% -0.005%;
purified water makes up 100%;
the stabilizer consists of organic phosphate and cyanuric acid with the weight ratio of (10-12) 1, wherein the organic phosphate is selected from any one or more of sodium aminotrimethylene phosphate, disodium hydroxyethylidene diphosphate and sodium hydroxyethylidene diphosphate;
the synergistic agent consists of (10-14) organic acid and octenidine in a weight ratio of (1), wherein the organic acid adopts one or more of pelargonic acid, octanoic acid and valeric acid;
the pH regulator adopts one or more of HCl, sodium phosphate, disodium hydrogen phosphate or sodium dihydrogen phosphate;
the preparation method of the hypochlorous acid disinfectant for improving stability and sterilizing effect comprises the following steps:
(1) Adding purified water into calcium hypochlorite to dilute until the effective chlorine concentration is 50-150 ppm, fully stirring for 1-1.5h, and filtering;
(2) Adding a stabilizing agent into the filtered solution, heating and stirring in a constant-temperature water bath at 37 ℃ for 2-2.5h, wherein the stirring speed is 150-200r/min;
(3) Adding glycol and stirring uniformly;
(4) Adding a synergistic agent and uniformly stirring;
(5) And adding a pH regulator to regulate the pH of the solution to 5-7, thus obtaining the hypochlorous acid disinfectant with improved stability and sterilization effect.
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|---|---|---|---|---|
| AU4725864A (en) * | 1963-07-26 | 1966-01-27 | Monsanto Co | Sequestering method and compositions for bleaching, sterilizing, disinfecting, and deterging |
| CN107820390A (en) * | 2015-05-14 | 2018-03-20 | 奥麒化工股份有限公司 | The tablet of hypochlorite containing slow mechanism dissolved |
| CN112120040A (en) * | 2020-09-24 | 2020-12-25 | 深圳中科环境治理科技有限公司 | Hypochlorous acid disinfectant and preparation method thereof |
| CN112913847A (en) * | 2021-01-18 | 2021-06-08 | 海韵一剑大卫生科技有限公司 | Chlorine-containing disinfectant for low-temperature environment and preparation method thereof |
| CN115886029A (en) * | 2023-01-04 | 2023-04-04 | 南通闪水生物科技有限公司 | Low-temperature hypochlorous acid disinfectant, and preparation method and application thereof |
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| PT1644024T (en) * | 2003-06-06 | 2019-10-24 | Univ Texas | Antimicrobial flush solutions |
| KR101694931B1 (en) * | 2009-01-06 | 2017-01-10 | 큐어론 엘엘씨 | Compositions and methods for the treatment or the prevention oral infections by e. coli |
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| AU4725864A (en) * | 1963-07-26 | 1966-01-27 | Monsanto Co | Sequestering method and compositions for bleaching, sterilizing, disinfecting, and deterging |
| CN107820390A (en) * | 2015-05-14 | 2018-03-20 | 奥麒化工股份有限公司 | The tablet of hypochlorite containing slow mechanism dissolved |
| CN112120040A (en) * | 2020-09-24 | 2020-12-25 | 深圳中科环境治理科技有限公司 | Hypochlorous acid disinfectant and preparation method thereof |
| CN112913847A (en) * | 2021-01-18 | 2021-06-08 | 海韵一剑大卫生科技有限公司 | Chlorine-containing disinfectant for low-temperature environment and preparation method thereof |
| CN115886029A (en) * | 2023-01-04 | 2023-04-04 | 南通闪水生物科技有限公司 | Low-temperature hypochlorous acid disinfectant, and preparation method and application thereof |
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