CN117643544A - Preparation method of capsule containing embryo extract - Google Patents
Preparation method of capsule containing embryo extract Download PDFInfo
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- CN117643544A CN117643544A CN202311670082.6A CN202311670082A CN117643544A CN 117643544 A CN117643544 A CN 117643544A CN 202311670082 A CN202311670082 A CN 202311670082A CN 117643544 A CN117643544 A CN 117643544A
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- 239000002775 capsule Substances 0.000 title claims abstract description 267
- 238000002360 preparation method Methods 0.000 title claims abstract description 43
- 210000001161 mammalian embryo Anatomy 0.000 title claims abstract description 23
- 238000000465 moulding Methods 0.000 claims abstract description 63
- 238000001125 extrusion Methods 0.000 claims abstract description 60
- 238000012512 characterization method Methods 0.000 claims abstract description 56
- 238000011049 filling Methods 0.000 claims abstract description 53
- 210000002242 embryoid body Anatomy 0.000 claims abstract description 26
- 239000011259 mixed solution Substances 0.000 claims abstract description 16
- 238000001816 cooling Methods 0.000 claims abstract description 7
- 238000001035 drying Methods 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims description 35
- 238000007711 solidification Methods 0.000 claims description 18
- 230000008023 solidification Effects 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 14
- 238000004458 analytical method Methods 0.000 claims description 11
- 230000000007 visual effect Effects 0.000 claims description 8
- 230000006578 abscission Effects 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 4
- 238000010586 diagram Methods 0.000 description 11
- 239000000843 powder Substances 0.000 description 6
- 241001122767 Theaceae Species 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 150000008442 polyphenolic compounds Chemical class 0.000 description 4
- 235000013824 polyphenols Nutrition 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 108010093924 embryonin Proteins 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000408 embryogenic effect Effects 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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Abstract
The invention relates to the technical field of embryosin capsule preparation, in particular to a preparation method of a capsule containing embryosin, which comprises the following steps: step S1, filling the uniformly mixed embryoid body-containing mixed solution into an extrusion groove of a molding unit, and extruding into capsules; s2, acquiring positions of a plurality of capsules falling from the molding unit to the conveyor belt within a preset time length, calculating falling position fluctuation values of the plurality of capsules, and judging whether the curing of the capsules is qualified or not; step S3, acquiring an acoustic wave signal of the unqualified capsule falling onto a conveyor belt within a preset time length, drawing an acoustic wave spectrogram, and calculating a capsule curing characterization coefficient based on an acoustic wave intensity value and a falling position fluctuation value of the acoustic wave spectrogram within the preset time length so as to select an adjustment mode of preparation parameters of the capsule; s4, conveying the capsules containing the embryoid bodies into a rotary drum through a conveyor belt, and drying and cooling; the invention improves the curing degree and the curing uniformity of the preparation of the capsules containing the embryo extract.
Description
Technical Field
The invention relates to the technical field of embryosin capsule preparation, in particular to a preparation method of a capsule containing embryosin.
Background
With the intensive research of embryo extract by research institutions at home and abroad, embryo extract-containing capsules are widely accepted by people as health products, and have higher requirements on the preparation process of embryo extract-containing capsules, and because the processes of embryo extract extraction, processing and the like are relatively complex, the production cost of embryo extract is higher, the qualification rate of finished products needs to be ensured for the preparation of embryo extract-containing capsules, the cost waste is avoided, and especially the curing uniformity of embryo extract-containing capsules is more and more valued by technicians in the related field, so that the curing uniformity of embryo extract-containing capsules is continuously improved, and the technological method of each link is improved endlessly.
For example, chinese patent publication No.: CN116687876a discloses a preparation process of embryo element capsule containing tea polyphenol, comprising: step S1, grinding embryos to obtain embryo extract powder, and placing the embryo extract powder and tea polyphenol powder into a stirrer according to a preset mixing weight ratio for mixing; step S2, when the mixing of the embryo extract powder and the tea polyphenol powder is completed, filling the mixture of the embryo extract powder and the tea polyphenol into the capsule shell by using capsule filling equipment; step S3, the central control module controls a visual sensor arranged in the capsule filling equipment to detect the bulge height of the filled capsule in a plurality of detection periods so as to calculate and obtain the average bulge height of the capsule; and S4, the central control module controls a weight sensor arranged at an output port of the filling equipment to periodically detect the weight of the capsule so as to calculate and obtain the average weight of the capsule.
The prior art has the following problems;
in the prior art, the defects of insufficient curing or difference in curing uniformity of the capsule caused by the difference in the curing process of the rapidly formed capsule in the process of preparing the capsule containing the embryo element at a high speed are not considered, and the adhesion of the capsule on the forming equipment and the impact deformation of the capsule in the process of falling off the capsule occur, so that the preparation efficiency and quality of the capsule containing the embryo element are affected.
Disclosure of Invention
Therefore, the invention provides a preparation method of a capsule containing embryo extract, which is used for solving the problems that the curing uniformity degree of the capsule containing embryo extract cannot be rapidly detected, the curing uniformity degree of the capsule cannot be intuitively represented by data, and the preparation parameters influencing the curing degree of the capsule cannot be correspondingly adjusted in the prior art.
In order to achieve the above object, the present invention provides a method for preparing a capsule containing embryonin, comprising:
step S1, filling the uniformly mixed embryoid body-containing mixed solution into an extrusion groove of a molding unit, and extruding into capsules;
s2, acquiring positions of a plurality of capsules falling from the molding unit to a conveyor belt within a preset time length, calculating falling position fluctuation values of a plurality of capsules, and judging whether the curing of the capsules is qualified or not based on the falling position fluctuation values;
step S3, obtaining an acoustic wave signal of the unqualified capsule falling onto a conveyor belt within a preset time length to draw an acoustic wave spectrogram, calculating a capsule curing characterization coefficient based on an acoustic wave intensity value of the acoustic wave spectrogram within the preset time length and the falling position fluctuation value to select an adjustment mode of preparation parameters of the capsule, wherein the adjustment mode comprises,
adjusting the filling speed of the embryoid body-containing mixed solution;
or, adjusting the extrusion force of the molding unit;
and S4, conveying the capsules containing the embryoid bodies into a rotary drum through the conveyor belt, and drying and cooling.
Further, in the step S2, the step of obtaining the positions of the plurality of capsules falling off from the molding unit to the conveyor belt within a predetermined time period includes,
s21, acquiring an image of the capsules falling off from the molding unit to a conveyor belt;
step S22, establishing a rectangular coordinate system on the image, wherein the rectangular coordinate system takes the direction along the surface of the conveyor belt as a transverse axis;
and S23, marking a horizontal axis coordinate value corresponding to the position of the capsule falling from the molding unit to the conveyor belt on the horizontal axis of the rectangular coordinate system, and determining the horizontal axis coordinate value as the falling horizontal axis coordinate value of the capsule.
Further, in the step S2, a fluctuation value X of the dropping position of the plurality of capsules is calculated according to the formula (1) c ，
In the formula (1), x i Coordinate value x of abscission horizontal axis of ith capsule av For the average value of the coordinate values of the abscissas of a plurality of capsules, i=1, 2,3 … n, n is the total number of the capsules.
Further, in the step S2, the fluctuation value of the drop position is compared with a preset fluctuation threshold value of the drop position to determine whether the curing of the capsule is qualified, wherein,
and if the fluctuation value of the falling position is larger than the fluctuation threshold value of the falling position, judging that the curing of the capsule is unqualified.
Further, in the step S3, the process of determining the sound intensity value of the sound spectrogram of the predetermined duration includes,
and acquiring intensity values of a plurality of peaks of the acoustic wave signals in the acoustic wave spectrogram on an ordinate, calculating an average value of the intensity values of a plurality of peaks on the ordinate, and determining the average value as the acoustic wave intensity value of the capsule falling onto a conveyor belt.
Further, in the step S3, a capsule curing characterization coefficient E is calculated according to a formula (2),
in the formula (2), DB m For the intensity value of the sound wave of the capsules falling off the conveyor belt, DB 0 Is a preset reference value of sound wave intensity, X c For the fluctuation value of the falling position of the capsule, X 0 For a preset reference value of fluctuation of the shedding position, alpha is a weight coefficient of sound wave intensity, beta is a weight coefficient of fluctuation of the shedding position, and alpha+beta=1 is satisfied.
Further, in the step S3, the capsule curing characterization coefficient is compared with a preset capsule curing characterization coefficient reference value to select an adjustment mode for the preparation parameters of the capsule, wherein,
if the capsule solidification characterization coefficient is smaller than or equal to the capsule solidification characterization coefficient reference value, selecting to adjust the filling speed of the embryoid body-containing mixed solution;
and if the capsule curing characterization coefficient is larger than the capsule curing characterization coefficient reference value, selecting to adjust the extrusion force of the molding unit.
Further, in the step S3, the filling speed of the mixed solution containing embryon is adjusted based on the capsule solidification characterization coefficient, wherein the adjustment amount of the filling speed is in a proportional relationship with the capsule solidification characterization coefficient.
Further, in the step S3, a plurality of extrusion force adjustment manners for adjusting the extrusion force of the molding unit based on the capsule curing characterization coefficient are preset, and the adjustment amounts of the extrusion force adjustment manners on the extrusion force of the molding unit are different.
Further, the present invention also provides a capsule preparation system containing embryon, comprising:
the molding unit comprises two rollers which are symmetrically arranged and can adjust the distance, and an extrusion groove is formed on the surface of each roller for molding capsules;
the material injection head is used for filling the embryoid body-containing mixed liquid into the extrusion groove;
the conveyor belt is arranged at the bottom of the molding unit and is used for conveying the molded capsules;
a drum for drying and cooling the capsules;
the acquisition module comprises a visual unit and an acoustic wave acquisition unit, wherein the visual unit is used for acquiring an image of the capsule falling off from the molding unit to the conveyor belt, and the acoustic wave acquisition unit is used for acquiring an acoustic wave signal of the unqualified capsule falling off from the conveyor belt within a preset time period;
the analysis execution module is connected with the acquisition module and comprises an analysis unit and an execution unit, wherein the analysis unit is used for calculating the fluctuation value of the falling position and the capsule solidification characterization coefficient, and the execution unit is used for adjusting the filling speed of the embryo-containing mixed liquid and the extrusion force of the molding unit.
Compared with the prior art, the method has the beneficial effects that by setting the steps S1 to S4, the method can acquire the characteristics of the adhesion of the capsule on the molding equipment caused by the curing difference on the surface of the rapidly molded capsule, visually characterize the curing uniformity degree of the capsule in a data mode, correspondingly adjust the preparation parameters influencing the curing degree of the capsule, improve the curing degree and the curing uniformity of the preparation of the capsule containing embryon, avoid the impact deformation of the capsule caused by insufficient curing or the curing uniformity difference in the capsule falling process, and improve the preparation efficiency and the quality of the capsule containing embryon.
In particular, whether the curing of the capsules is qualified or not is judged based on the fluctuation values of the falling positions of a plurality of capsules, in the actual capsule preparation process, if the difference of the curing process of the capsules causes insufficient curing or difference of curing uniformity, the capsules are adhered to the extrusion grooves, the falling process cannot cleanly fall down, the positions of the capsules falling to the conveying belt cannot be concentrated at a certain position, the difference of the falling positions is large, and the phenomenon that the capsules are adhered to the extrusion grooves of the molding units is represented under the condition of large fluctuation by calculating the fluctuation condition of the positions of the capsules falling to the conveying belt, so that the curing of the capsules is unqualified, and the abnormal curing is rapidly identified.
In particular, the average value of the intensity values of a plurality of peaks on the ordinate in the acoustic spectrogram is obtained, and the intensity value of the acoustic wave falling off the capsule to the conveyor belt is determined, so that in the actual capsule preparation process, the intensity of the acoustic wave falling off the conveyor belt is weaker due to softer texture of the capsule, the capsule with uneven hardness is solidified, and the average value of the intensity of the acoustic wave falling off the conveyor belt is weaker, so that the preparation solidification degree and solidification uniformity of the capsule can be rapidly and intuitively represented through the intensity value of the acoustic wave falling off the capsule to the conveyor belt.
In particular, the invention calculates the capsule curing characterization coefficient through the acoustic intensity value and the shedding position fluctuation value of the acoustic spectrogram with preset duration, compares the acoustic intensity value of the capsule shedding to the conveyor belt with the preset acoustic intensity reference value in the actual capsule preparation process, and more comprehensively calculates the capsule curing characterization coefficient which can characterize the difference of the capsule preparation curing degree and the curing uniformity, and further, the datamation intuitively characterizes the curing degree and the curing uniformity of the capsule by comparing the shedding position fluctuation value of the capsule with the preset shedding position fluctuation reference value, the larger the shedding position fluctuation value of the capsule, the worse the curing degree or the worse the curing uniformity of the capsule preparation is, and the combination calculation of the acoustic intensity value of the capsule shedding to the conveyor belt and the shedding position fluctuation value of the capsule.
In particular, the invention adjusts the filling speed of the embryoid-containing mixed liquid through the capsule curing characterization coefficient, under the condition that the curing degree and the curing uniformity of the capsule are slightly poor, the filling speed of the embryoid-containing mixed liquid is possibly too high, the fast filling speed impacts the uncured shell of the capsule, and the curing uniformity of the shell of the capsule is influenced.
Particularly, the extrusion force of the molding unit is adjusted through the capsule curing characterization coefficient, under the condition that the capsule curing degree and the curing uniformity are extremely poor, the thickness uniformity of the gelatin tape for preparing the capsules can be different, the extrusion force of the molding unit is required to be increased to uniformly distribute the thickness of the shell in the capsule molding process, further, the preparation parameters influencing the curing degree of the capsules are adaptively adjusted, the curing uniformity of the capsules is improved, and the preparation efficiency and quality of the capsules containing embryon are improved.
Drawings
FIG. 1 is a step diagram of a method for preparing a capsule containing embryodins according to an embodiment of the present invention;
FIG. 2 is a step diagram of acquiring the position of a plurality of capsules falling off from a molding unit to a conveyor belt within a predetermined time period according to an embodiment of the present invention;
FIG. 3 is a diagram of determining coordinate values of a abscission axis of a capsule according to an embodiment of the present invention;
FIG. 4 is a logic flow diagram of a selected adjustment of the preparation parameters of a capsule in accordance with an embodiment of the present invention;
FIG. 5 is a schematic diagram showing the structure of a system for preparing embryonated capsules according to an embodiment of the present invention;
in the figure, 1: roller, 2: extrusion groove, 3: injection head, 4: conveyor belt, 5: a rotary drum (6): visual unit, 7: and the sound wave acquisition unit.
Detailed Description
In order that the objects and advantages of the invention will become more apparent, the invention will be further described with reference to the following examples; it should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
Preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are merely for explaining the technical principles of the present invention, and are not intended to limit the scope of the present invention.
It should be noted that, in the description of the present invention, terms such as "upper," "lower," "left," "right," "inner," "outer," and the like indicate directions or positional relationships based on the directions or positional relationships shown in the drawings, which are merely for convenience of description, and do not indicate or imply that the apparatus or elements must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention.
Furthermore, it should be noted that, in the description of the present invention, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention can be understood by those skilled in the art according to the specific circumstances.
Referring to fig. 1, which is a step diagram of a method for preparing a capsule containing embryonin according to an embodiment of the present invention, the method for preparing a capsule containing embryonin of the present invention comprises:
step S1, filling the uniformly mixed embryoid body-containing mixed solution into an extrusion groove 2 of a molding unit, and extruding into capsules;
s2, acquiring positions of a plurality of capsules falling from the molding unit to the conveyor belt 4 within a preset time length, calculating falling position fluctuation values of a plurality of capsules, and judging whether the curing of the capsules is qualified or not based on the falling position fluctuation values;
step S3, obtaining an acoustic wave signal of the unqualified capsule falling onto the conveyor belt 4 within a preset time length to draw an acoustic wave spectrogram, calculating a capsule curing characterization coefficient based on an acoustic wave intensity value of the acoustic wave spectrogram within the preset time length and the falling position fluctuation value to select an adjustment mode of preparation parameters of the capsule, wherein the adjustment mode comprises,
adjusting the filling speed of the embryoid body-containing mixed solution;
or, adjusting the extrusion force of the molding unit;
and S4, conveying the capsules containing the embryodins into a rotary drum 5 through the conveyor belt 4, and drying and cooling.
Specifically, the preset time length in the present invention is set to ensure that the number of acquired dropped capsules is sufficiently large, and in the embodiment of the present invention, the preset time length may be set to have a value range of [5,30], with the unit being s.
Specifically, referring to fig. 2 and 3, fig. 2 is a step diagram of obtaining positions of a plurality of capsules falling from a molding unit to a conveyor belt 4 within a predetermined time period according to an embodiment of the present invention, and fig. 3 is a schematic diagram of determining coordinate values of falling horizontal axes of capsules according to an embodiment of the present invention, in the step S2, the step of obtaining positions of a plurality of capsules falling from the molding unit to the conveyor belt 4 within a predetermined time period includes,
step S21, obtaining an image of the capsules falling off from the molding unit to the conveyor belt 4;
step S22, establishing a rectangular coordinate system on the image, wherein the rectangular coordinate system takes the direction along the surface of the conveyor belt 4 as a transverse axis;
and S23, marking a horizontal axis coordinate value corresponding to the position of the capsule falling from the molding unit to the conveyor belt 4 on the horizontal axis of the rectangular coordinate system, and determining the horizontal axis coordinate value as a falling horizontal axis coordinate value of the capsule.
For example, please continue to refer to fig. 3, which is a schematic diagram of determining a coordinate value of a horizontal axis of falling of a capsule according to an embodiment of the present invention, marking a coordinate value of a horizontal axis corresponding to a position of falling of the capsule from the molding unit to the conveyor belt 4 on the horizontal axis of a rectangular coordinate system, and determining the coordinate value of the horizontal axis as a coordinate value X of falling of the capsule 1 、X 2 、X 3 、X 4 、X 5 。
Specifically, in the step S2, a fluctuation value X of the dropping position of a plurality of capsules is calculated according to the formula (1) c ，
In the formula (1), x i Coordinate value x of abscission horizontal axis of ith capsule av For the average value of the coordinate values of the abscissas of a plurality of capsules, i=1, 2,3 … n, n is the total number of the capsules.
Specifically, in the step S2, the fluctuation value of the drop position is compared with a preset fluctuation threshold value of the drop position to determine whether the curing of the capsule is qualified, wherein,
if the falling position fluctuates by a value X c Greater than the drop-off position fluctuation threshold X cw And judging that the curing of the capsule is not qualified.
Specifically, the drop position fluctuation threshold value X cw The value range of (2) is [10,15 ]]The interval unit is cm.
Specifically, whether the curing of the capsules is qualified or not is judged based on the fluctuation values of the falling positions of a plurality of capsules, in the actual capsule preparation process, if the difference of the curing process of the capsules causes insufficient curing or difference of curing uniformity, the capsules are adhered to the extrusion groove 2, the falling process cannot cleanly fall, the positions of the capsules falling to the conveying belt cannot be concentrated at a certain position, the difference of the falling positions is large, and the phenomenon that the capsules are adhered to the extrusion groove 2 of the molding unit is represented under the condition of large fluctuation by calculating the fluctuation condition of the positions of the capsules falling to the conveying belt, so that the curing of the capsules is unqualified, and further, the rapid identification of the curing abnormality is realized.
In particular, in the step S3, the process of determining the sound wave intensity value of the sound wave spectrogram of the predetermined time period includes,
acquiring the sound wave signals in the sound wave spectrogramThe intensity value of the dry wave crest on the ordinate, the average value of the intensity values of a plurality of wave crests on the ordinate is calculated, and the average value is determined as the sound wave intensity value DB of the capsules falling onto the conveyor belt 4 m 。
Specifically, the average value of the intensity values of a plurality of peaks on the ordinate in the acoustic spectrogram is obtained, the intensity value of the acoustic wave falling off the capsule to the conveyor belt 4 is determined, in the actual capsule preparation process, the intensity of the acoustic wave falling off the conveyor belt 4 is weak due to the fact that the texture of the capsule is softer, the capsule with uneven hardness is solidified, the average value of the intensity of the acoustic wave falling off the conveyor belt 4 is also weaker, and therefore the preparation solidification degree and solidification uniformity of the capsule can be rapidly and intuitively represented through the intensity value of the acoustic wave falling off the capsule to the conveyor belt 4.
Specifically, referring to fig. 4, which is a logic flow diagram of a method for selecting and adjusting parameters of capsule preparation according to an embodiment of the present invention, in step S3, a capsule curing characterization coefficient E is calculated according to formula (2),
in the formula (2), DB m For the intensity value of the sound wave, DB, of the capsules falling onto the conveyor belt 4 0 Is a preset reference value of sound wave intensity, X c For the fluctuation value of the falling position of the capsule, X c0 For a preset reference value of fluctuation of the shedding position, alpha is a weight coefficient of sound wave intensity, beta is a weight coefficient of fluctuation of the shedding position, and alpha+beta=1 is satisfied.
Preferably, in the embodiment of the present invention, the sound wave intensity reference value DB 0 Based on the pre-test, pre-testing the average value of the signal intensity of the sound wave emitted by the capsules falling onto the conveyor belt 4 within a certain period of time, and recording the average value of the signal intensity as the sound wave intensity reference value DB 0 Reference value X of fluctuation of falling position c0 ＝ε×X cw Wherein epsilon is a value factor, and the value range of epsilon is [1.05,1.08 ]]。
Specifically, the invention calculates the capsule curing characterization coefficient through the acoustic intensity value and the shedding position fluctuation value of the acoustic spectrogram with preset duration, compares the acoustic intensity value of the capsules shed to the conveyor belt 4 with the preset acoustic intensity reference value in the actual capsule preparation process, and further, the smaller the acoustic intensity value of the capsules shed to the conveyor belt 4 is, the worse the capsule preparation curing degree or the worse the curing uniformity is, the larger the shedding position fluctuation value of the capsules is compared with the preset shedding position fluctuation reference value, the worse the capsule preparation curing degree or the worse the curing uniformity is, the combination calculation of the acoustic intensity value of the capsules shed to the conveyor belt 4 and the shedding position fluctuation value of the capsules is performed, and the capsule curing characterization coefficient capable of characterizing the capsule preparation curing degree and the curing uniformity difference is calculated more comprehensively.
Specifically, in the step S3, the capsule curing characterization coefficient is compared with a preset capsule curing characterization coefficient reference value to select an adjustment mode for the preparation parameters of the capsule, wherein,
if the capsule curing characterization coefficient E is less than or equal to the capsule curing characterization coefficient reference value E c Selecting and adjusting the filling speed of the embryoid body-containing mixed solution;
if the capsule curing characterization coefficient E is greater than the capsule curing characterization coefficient reference value E c And selecting and adjusting the extrusion force of the molding unit.
Preferably, in an embodiment of the present invention, the capsule curing characterization coefficient reference value E c The value range of (5) is [1.2,1.25 ]]。
Specifically, in the step S3, the filling speed of the embryon-containing mixed liquid is adjusted based on the capsule solidification characterization coefficient E, wherein the adjustment amount of the filling speed is in a proportional relationship with the capsule solidification characterization coefficient.
Preferably, in this embodiment, at least three adjustments of the embryogenic mix based on the capsule cure characterization coefficient E are setA filling speed adjusting mode of the filling speed of the liquid, wherein the capsule curing characterization coefficient E is compared with a preset first curing characterization coefficient contrast value E 1 Second cure characterization coefficient contrast value E 2 In the comparison of the two types of materials,
if E < E 1 Selecting a first filling speed adjusting mode, wherein the first filling speed adjusting mode is to adjust the filling speed of the embryoid body-containing mixed solution to a first filling speed V 1 Set V 1 ＝V 0 －Δv 1 ；
If E 1 ≤E≤E 2 Selecting a second filling speed adjusting mode, wherein the second filling speed adjusting mode is to adjust the filling speed of the embryoid body-containing mixed solution to a second filling speed V 2 Set V 2 ＝V 0 －Δv 2 ；
If E > E 2 Selecting a third filling speed adjusting mode, wherein the third filling speed adjusting mode is to adjust the filling speed of the embryoid body-containing mixed solution to a third filling speed V 1 Set V 3 ＝V 0 －Δv 3 ；
Wherein V is 0 Representing the initial value of the filling speed of the embryoid body-containing mixed liquid, deltav 1 Represents the first filling speed adjustment quantity, deltav 2 Represents the second filling speed adjustment quantity, deltav 3 Representing a third filling rate adjustment, in this example, in order to make the first cure characteristic coefficient vs. value E 1 Second cure characterization coefficient contrast value E 2 Can distinguish the difference of the curing uniformity of the capsules, E is set in the embodiment 1 ＝0.9×E c ，E 2 ＝0.93×E c In order to make the adjustment effective and avoid the adjustment amount from being too large, in the present embodiment, 0.1V 0 ≤Δv 1 ＜Δv 2 ＜Δv 3 ≤0.25V 0 。
Specifically, the filling speed of the embryon-containing mixed liquid is adjusted through the capsule curing characterization coefficient, under the condition that the curing degree and the curing uniformity of the capsule are slightly poor, the filling speed of the embryon-containing mixed liquid is possibly too high, the fast filling speed impacts the uncured shell of the capsule, and the curing uniformity of the shell of the capsule is influenced.
Specifically, in step S3, a plurality of extrusion force adjustment manners for adjusting the extrusion force of the molding unit based on the capsule curing characterization coefficient E are preset, and the adjustment amounts of the extrusion force adjustment manners on the extrusion force of the molding unit are different.
Preferably, in this embodiment, at least three extrusion force adjustment modes for adjusting the extrusion force of the molding unit based on the capsule curing characterization coefficient E are set, where the capsule curing characterization coefficient E is compared with a preset third curing characterization coefficient comparison value E 3 Fourth cure characterization coefficient contrast value E 4 In the comparison of the two types of materials,
if E < E 3 Selecting a first extrusion force adjusting mode, wherein the first extrusion force adjusting mode is to adjust the extrusion force of the molding unit to a first extrusion force F 1 Setting F 1 ＝F 0 +ΔF 1 ；
If E 3 ≤E≤E 4 Selecting a second extrusion force adjusting mode, wherein the second extrusion force adjusting mode is to adjust the extrusion force of the molding unit to a second extrusion force F 2 Setting F 2 ＝F 0 +ΔF 2 ；
If E > E 4 Selecting a third extrusion force adjusting mode, wherein the third extrusion force adjusting mode is to adjust the extrusion force of the molding unit to a third extrusion force F 3 Setting F 3 ＝F 0 +ΔF 3 ；
Wherein F is 0 Represents the initial value of extrusion force and delta F of the molding unit 1 Represents the first extrusion force adjustment quantity, deltaF 2 Represents the second extrusion force adjustment quantity, deltaF 3 Represents a third extrusion force adjustment amount, in this embodiment, in order to make the third cure characteristic coefficient vs. value E 3 Fourth cure characterization coefficient contrast value E 4 Can distinguish the difference of the curing uniformity of the capsules, E is set in the embodiment 3 ＝1.05×E c ，E 4 ＝1.1×E c In order to make the adjustment effective and avoid the adjustment amount from being too large, in the present embodiment, 0.1F 0 ≤ΔF 1 ＜ΔF 2 ＜ΔF 3 ≤0.25F 0 。
Specifically, the extrusion force of the molding unit is adjusted through the capsule curing characterization coefficient, under the condition that the capsule curing degree and the curing uniformity are extremely poor, the thickness uniformity of the gelatin tape for preparing the capsules can be different, the extrusion force of the molding unit is required to be increased to uniformly distribute the thickness of the shell in the capsule molding process, and further, the preparation parameters influencing the curing degree of the capsules are adaptively adjusted, the curing uniformity of the capsules is improved, and the preparation efficiency and quality of the capsules containing embryon are improved.
Specifically, the present invention also provides a system for preparing a capsule containing embryoid bodies, as shown in fig. 5, which is a schematic structural diagram of a system for preparing a capsule containing embryoid bodies according to an embodiment of the present invention, comprising:
the molding unit comprises two rollers 1 which are symmetrically arranged and can adjust the distance, and an extrusion groove 2 is arranged on the surface of each roller 1 for molding capsules;
a filling head 3 for filling the mixed liquid containing embryoid bodies into the extrusion tank 2;
a conveyor belt 4 arranged at the bottom of the molding unit for conveying the molded capsules;
a drum 5 for drying and cooling the capsules;
the acquisition module comprises a visual unit 6 and an acoustic wave acquisition unit 7, wherein the visual unit 6 is used for acquiring an image of the capsules falling off from the molding unit to the conveyor belt 4, and the acoustic wave acquisition unit 7 is used for acquiring an acoustic wave signal of the unqualified capsules falling off from the conveyor belt 4 within a preset time period;
the analysis execution module is connected with the acquisition module and comprises an analysis unit and an execution unit, wherein the analysis unit is used for calculating the fluctuation value of the falling position and the capsule solidification characterization coefficient, and the execution unit is used for adjusting the filling speed of the embryo-containing mixed liquid and the extrusion force of the molding unit.
Specifically, the specific manner of adjusting the extrusion force of the molding unit is not limited in the present invention, and preferably, in the embodiment of the present invention, the adjustment of the extrusion force may be achieved by adjusting the distance between the two rollers 1 of the molding unit, which is the prior art and will not be described herein.
Specifically, the method for adjusting the filling speed of the embryoid body-containing mixed solution is not limited, and preferably, in the embodiment of the present invention, the filling speed of the embryoid body-containing mixed solution of the injection head 3 can be adjusted by adjusting the operation power of the injection pump, which is the prior art and is not described herein.
Specifically, the specific structure of the vision unit 6 is not limited, and preferably, in the embodiment of the invention, the vision unit may be a high-definition camera and a module with an image processing device, which is a prior art and is not described herein.
Specifically, the specific structure of the acoustic wave acquisition unit 7 is not limited, the acoustic wave acquisition unit can convert sound into an electric signal or a digital signal, and the received acoustic wave signal is amplified, filtered, digitized and the like to obtain an acoustic wave spectrogram, and the technology is widely applied to the fields of medical ultrasonic detection, industrial nondestructive detection, geological exploration and the like and is not repeated here.
Specifically, the specific structure of the analysis execution module is not limited, and the analysis execution module itself or each unit therein may be formed by using a logic component, where the logic component may be a field programmable logic component, a microprocessor, a processor used in a computer, and the like, and will not be described herein.
Thus far, the technical solution of the present invention has been described in connection with the preferred embodiments shown in the drawings, but it is easily understood by those skilled in the art that the scope of protection of the present invention is not limited to these specific embodiments. Equivalent modifications and substitutions for related technical features may be made by those skilled in the art without departing from the principles of the present invention, and such modifications and substitutions will be within the scope of the present invention.
The foregoing description is only of the preferred embodiments of the invention and is not intended to limit the invention; various modifications and variations of the present invention will be apparent to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A method for preparing a capsule containing embryoid bodies, comprising:
step S1, filling the uniformly mixed embryoid body-containing mixed solution into an extrusion groove of a molding unit, and extruding into capsules;
s2, acquiring positions of a plurality of capsules falling from the molding unit to a conveyor belt within a preset time length, calculating falling position fluctuation values of a plurality of capsules, and judging whether the curing of the capsules is qualified or not based on the falling position fluctuation values;
step S3, obtaining an acoustic wave signal of the unqualified capsule falling onto a conveyor belt within a preset time length to draw an acoustic wave spectrogram, calculating a capsule curing characterization coefficient based on an acoustic wave intensity value of the acoustic wave spectrogram within the preset time length and the falling position fluctuation value to select an adjustment mode of preparation parameters of the capsule, wherein the adjustment mode comprises,
adjusting the filling speed of the embryoid body-containing mixed solution;
or, adjusting the extrusion force of the molding unit;
and S4, conveying the capsules containing the embryoid bodies into a rotary drum through the conveyor belt, and drying and cooling.
2. The method for preparing embryoid bodies containing capsules according to claim 1, wherein the step of obtaining the positions of the plurality of capsules falling off the molding unit to the conveyor belt within a predetermined period of time in the step S2 comprises,
s21, acquiring an image of the capsules falling off from the molding unit to a conveyor belt;
step S22, establishing a rectangular coordinate system on the image, wherein the rectangular coordinate system takes the direction along the surface of the conveyor belt as a transverse axis;
and S23, marking a horizontal axis coordinate value corresponding to the position of the capsule falling from the molding unit to the conveyor belt on the horizontal axis of the rectangular coordinate system, and determining the horizontal axis coordinate value as the falling horizontal axis coordinate value of the capsule.
3. The method of claim 2, wherein in step S2, the fluctuation value X of the falling position of the plurality of capsules is calculated according to the formula (1) c ，
In the formula (1), x i Coordinate value x of abscission horizontal axis of ith capsule av For the average value of the coordinate values of the abscissas of a plurality of capsules, i=1, 2,3 … n, n is the total number of the capsules.
4. The method for preparing a capsule containing embryon according to claim 3, wherein in the step S2, the fluctuation value of the abscission position is compared with a preset fluctuation threshold value of the abscission position to determine whether the capsule is qualified for curing, wherein,
and if the fluctuation value of the falling position is larger than the fluctuation threshold value of the falling position, judging that the curing of the capsule is unqualified.
5. The method for preparing a capsule containing embryon according to claim 1, wherein the process of determining the sound intensity value of the sound spectrogram of the predetermined time period in the step S3 includes,
and acquiring intensity values of a plurality of peaks of the acoustic wave signals in the acoustic wave spectrogram on an ordinate, calculating an average value of the intensity values of a plurality of peaks on the ordinate, and determining the average value as the acoustic wave intensity value of the capsule falling onto a conveyor belt.
6. The method of claim 5, wherein in the step S3, the capsule solidification characterization coefficient E is calculated according to the formula (2),
in the formula (2), DB m For the intensity value of the sound wave of the capsules falling off the conveyor belt, DB 0 Is a preset reference value of sound wave intensity, X c For the fluctuation value of the falling position of the capsule, X 0 And alpha is a weight coefficient of sound wave intensity, and beta is a weight coefficient of fluctuation of the shedding position.
7. The method according to claim 6, wherein in the step S3, the capsule curing characterization coefficient is compared with a preset capsule curing characterization coefficient reference value to select a mode of adjusting the preparation parameters of the capsule,
if the capsule solidification characterization coefficient is smaller than or equal to the capsule solidification characterization coefficient reference value, selecting to adjust the filling speed of the embryoid body-containing mixed solution;
and if the capsule curing characterization coefficient is larger than the capsule curing characterization coefficient reference value, selecting to adjust the extrusion force of the molding unit.
8. The method according to claim 3, wherein in the step S3, the filling rate of the embryon-containing mixed liquid is adjusted based on the capsule solidification characterization coefficient, and wherein the adjustment amount of the filling rate is in direct proportion to the capsule solidification characterization coefficient.
9. The method of claim 3, wherein in the step S3, a plurality of extrusion force adjustment methods for adjusting the extrusion force of the molding unit based on the capsule curing characterization coefficient are preset, and the adjustment amounts of the extrusion force adjustment methods on the extrusion force of the molding unit are different.
10. A system for preparing a capsule containing embryon, applied to the method for preparing a capsule containing embryon according to any one of claims 1 to 9, comprising:
the molding unit comprises two rollers which are symmetrically arranged and can adjust the distance, and an extrusion groove is formed on the surface of each roller for molding capsules;
the material injection head is used for filling the embryoid body-containing mixed liquid into the extrusion groove;
the conveyor belt is arranged at the bottom of the molding unit and is used for conveying the molded capsules;
a drum for drying and cooling the capsules;
the acquisition module comprises a visual unit and an acoustic wave acquisition unit, wherein the visual unit is used for acquiring an image of the capsule falling off from the molding unit to the conveyor belt, and the acoustic wave acquisition unit is used for acquiring an acoustic wave signal of the unqualified capsule falling off from the conveyor belt within a preset time period;
the analysis execution module is connected with the acquisition module and comprises an analysis unit and an execution unit, wherein the analysis unit is used for calculating the fluctuation value of the falling position and the capsule solidification characterization coefficient, and the execution unit is used for adjusting the filling speed of the embryo-containing mixed liquid and the extrusion force of the molding unit.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311670082.6A CN117643544A (en) | 2023-12-07 | 2023-12-07 | Preparation method of capsule containing embryo extract |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311670082.6A CN117643544A (en) | 2023-12-07 | 2023-12-07 | Preparation method of capsule containing embryo extract |
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| CN117643544A true CN117643544A (en) | 2024-03-05 |
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| CN202311670082.6A Pending CN117643544A (en) | 2023-12-07 | 2023-12-07 | Preparation method of capsule containing embryo extract |
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| CN (1) | CN117643544A (en) |
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- 2023-12-07 CN CN202311670082.6A patent/CN117643544A/en active Pending
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