CN117598928A - Capsule-wrapped perfuming composition and intervening type tooth gap cleaning product - Google Patents
Capsule-wrapped perfuming composition and intervening type tooth gap cleaning product Download PDFInfo
- Publication number
- CN117598928A CN117598928A CN202310638387.2A CN202310638387A CN117598928A CN 117598928 A CN117598928 A CN 117598928A CN 202310638387 A CN202310638387 A CN 202310638387A CN 117598928 A CN117598928 A CN 117598928A
- Authority
- CN
- China
- Prior art keywords
- parts
- essence
- perfuming composition
- cyclodextrin
- starch
- Prior art date
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- Pending
Links
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- 238000004140 cleaning Methods 0.000 title claims abstract description 48
- 229920000642 polymer Polymers 0.000 claims abstract description 25
- 238000005538 encapsulation Methods 0.000 claims abstract description 9
- 239000010410 layer Substances 0.000 claims description 151
- 241000628997 Flos Species 0.000 claims description 112
- 229920000858 Cyclodextrin Polymers 0.000 claims description 73
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 58
- GUOCOOQWZHQBJI-UHFFFAOYSA-N 4-oct-7-enoxy-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)OCCCCCCC=C GUOCOOQWZHQBJI-UHFFFAOYSA-N 0.000 claims description 49
- 229940080313 sodium starch Drugs 0.000 claims description 49
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- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 38
- 239000002994 raw material Substances 0.000 claims description 38
- 239000001116 FEMA 4028 Substances 0.000 claims description 36
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 36
- 229960004853 betadex Drugs 0.000 claims description 36
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 34
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- 238000000576 coating method Methods 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 18
- 239000000654 additive Substances 0.000 claims description 15
- 239000000126 substance Substances 0.000 claims description 13
- 239000002304 perfume Substances 0.000 claims description 9
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- 240000007472 Leucaena leucocephala Species 0.000 claims description 5
- 235000010643 Leucaena leucocephala Nutrition 0.000 claims description 5
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- 235000011684 Sorghum saccharatum Nutrition 0.000 claims description 5
- 244000153158 Ammi visnaga Species 0.000 claims description 4
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- 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims description 3
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims description 3
- 229940043377 alpha-cyclodextrin Drugs 0.000 claims description 3
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims description 3
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims description 3
- 239000002346 layers by function Substances 0.000 claims description 2
- 240000008042 Zea mays Species 0.000 claims 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 1
- 235000005822 corn Nutrition 0.000 claims 1
- 239000003205 fragrance Substances 0.000 abstract description 44
- 238000003860 storage Methods 0.000 abstract description 30
- 230000002045 lasting effect Effects 0.000 abstract description 12
- 239000002775 capsule Substances 0.000 abstract description 11
- 230000008901 benefit Effects 0.000 abstract description 7
- 230000014759 maintenance of location Effects 0.000 abstract description 5
- 230000036541 health Effects 0.000 abstract description 4
- 230000000474 nursing effect Effects 0.000 abstract description 2
- 238000005979 thermal decomposition reaction Methods 0.000 abstract description 2
- 239000000686 essence Substances 0.000 description 144
- 230000000694 effects Effects 0.000 description 33
- 239000000796 flavoring agent Substances 0.000 description 24
- 235000019634 flavors Nutrition 0.000 description 24
- 239000000843 powder Substances 0.000 description 12
- 230000007774 longterm Effects 0.000 description 11
- 238000002156 mixing Methods 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 229920000945 Amylopectin Polymers 0.000 description 8
- 229920002261 Corn starch Polymers 0.000 description 7
- 230000001070 adhesive effect Effects 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 239000008120 corn starch Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 238000007790 scraping Methods 0.000 description 7
- 239000000853 adhesive Substances 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 208000002064 Dental Plaque Diseases 0.000 description 5
- 235000006679 Mentha X verticillata Nutrition 0.000 description 5
- 235000002899 Mentha suaveolens Nutrition 0.000 description 5
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 238000004945 emulsification Methods 0.000 description 5
- 239000003094 microcapsule Substances 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 4
- 125000003342 alkenyl group Chemical group 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 4
- 238000010668 complexation reaction Methods 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 239000000416 hydrocolloid Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- 235000010254 Jasminum officinale Nutrition 0.000 description 3
- 240000005385 Jasminum sambac Species 0.000 description 3
- 229920000881 Modified starch Polymers 0.000 description 3
- 240000007594 Oryza sativa Species 0.000 description 3
- 235000007164 Oryza sativa Nutrition 0.000 description 3
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- 229940083982 sodium phytate Drugs 0.000 description 3
- 235000013599 spices Nutrition 0.000 description 3
- 229920001661 Chitosan Polymers 0.000 description 2
- 240000000560 Citrus x paradisi Species 0.000 description 2
- 235000016623 Fragaria vesca Nutrition 0.000 description 2
- 240000009088 Fragaria x ananassa Species 0.000 description 2
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 244000246386 Mentha pulegium Species 0.000 description 2
- 235000016257 Mentha pulegium Nutrition 0.000 description 2
- 235000004357 Mentha x piperita Nutrition 0.000 description 2
- 240000008790 Musa x paradisiaca Species 0.000 description 2
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 238000005411 Van der Waals force Methods 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 229940069521 aloe extract Drugs 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000002826 coolant Substances 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 235000001050 hortel pimenta Nutrition 0.000 description 2
- 230000005923 long-lasting effect Effects 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 235000002020 sage Nutrition 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- 239000011775 sodium fluoride Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- FPJRGEOLQICYQZ-FHLIZLRMSA-N (1r,2s,5r)-n-[4-(cyanomethyl)phenyl]-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1C(=O)NC1=CC=C(CC#N)C=C1 FPJRGEOLQICYQZ-FHLIZLRMSA-N 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010018276 Gingival bleeding Diseases 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 235000014104 aloe vera supplement Nutrition 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 230000035597 cooling sensation Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 239000003975 dentin desensitizing agent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229960003284 iron Drugs 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000008204 material by function Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000003578 releasing effect Effects 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
Abstract
The application relates to a capsule-wrapped perfuming composition and an intervention type tooth gap cleaning product, belonging to the field of tooth health care and nursing. The capsule-wrapped perfuming composition comprises an essence inner core and an outer wrapping layer; the essence inner core contains essence and a first wrapping layer wrapping the surface of the essence; the first encapsulation layer includes an amphiphilic polymer. The intervention type tooth seam cleaning product has the advantages that the fragrance-giving composition wrapped by the load capsule is utilized, the first wrapping layer and the outer wrapping layer in the fragrance-giving composition are matched to play a slow-release role on essence, long-time lasting fragrance retention of the product is realized, volatilization and thermal decomposition of the essence can be prevented, and long-time stable storage of the product is facilitated.
Description
Technical Field
The application relates to the field of tooth health care and nursing, in particular to a capsule-wrapped perfuming composition and an intervention type tooth gap cleaning product.
Background
The intervening type tooth gap cleaning products comprise dental floss, toothpicks, tooth gap brushes and the like, can conveniently remove dirt on tooth gaps and tooth surfaces, and keep clean and healthy. The intervening type tooth gap cleaning product is loaded with essence and/or functional components, so that the product has the effects of freshening breath, removing dental plaque and the like. Existing mainstream interventional type tooth space cleaning products such as dental floss products generally adopt the steps of directly mixing and coating essence and/or functional components with an adhesive on the dental floss products, and enabling the essence and/or functional components of the coating layer to be in contact with teeth to exert effects while removing food residues through contact friction between a dental floss body and the teeth.
However, the essence itself has the characteristics of being volatile and poor in stability, and when being loaded on dental floss, the fragrance concentration of the dental floss can be greatly reduced along with the extension of the storage time, namely the fragrance cannot be kept for a long time, so that the fragrance and the cool feeling felt between teeth are weaker during use. Some dental floss products are flavored with powdered flavors, which are applied to dental floss after being diluted with water. The powder essence has low essence content, and has the problems of higher solid content and weak adhesion capability. Therefore, after the dental floss is flavored, the phenomenon of powder falling can be caused by insufficient fragrance concentration and insufficient adhesive force. In addition, the dental floss body is thinner, essence and functional components are not easy to carry, and the problems of agglomeration and the like are easy to occur when the dental floss body is dried after part of the adhesive is adhered to the dental floss, so that the storage stability of the functional dental floss is poor, the problem of powder falling is easy to occur after long-term storage, and the using effect of the functional dental floss is affected.
Disclosure of Invention
The first object of the present application is to provide a capsule-encapsulated perfuming composition, which has a good slow-release effect, a high initial concentration of fragrance and/or cooling sensation, and a lasting fragrance when applied in a tooth gap by the cooperation of the microcapsule structures of a first encapsulation layer and an outer encapsulation layer.
The second aim of the application is to provide an intervention type tooth seam cleaning product, through the perfuming composition of carrying on the capsule parcel on the product, utilize first parcel layer and outer parcel layer parcel essence to slow down essence and volatilize, do benefit to and stay fragrant, and have the advantage that stability is good, do benefit to long-term storage of product.
The capsule-wrapped perfuming composition adopts the following scheme:
a capsule-encapsulated perfuming composition comprises an essence core and an outer wrapping layer; the essence inner core contains essence and a first wrapping layer wrapping the surface of the essence; the first encapsulation layer includes an amphiphilic polymer. The perfuming composition wraps essence through the amphiphilic polymer to form a first wrapping layer, the outer wrapping layer wraps the essence inner core, the slow-release effect is achieved through two-layer wrapping cooperation, long-time lasting fragrance retention of the perfuming composition in the process of applying in a tooth gap is achieved, volatilization and thermal decomposition of essence can be prevented, and long-time stable storage is facilitated.
Preferably, the flavour comprises an oil-soluble flavour; according to the perfuming composition, the lipophilic group of the amphiphilic polymer is combined with the essence, and the hydrophilic group is matched with the amphiphilic polymer to stretch into water to form a layer of interfacial film between oil and water phases, so that the essence is wrapped, the functions of reducing interfacial tension and free energy of a system are achieved, the solubilization and emulsification capacity of the essence is enhanced, and the subsequent wrapping of an outer wrapping layer is facilitated. Illustratively, the fragrances of the present application may comprise oil-soluble fragrances and/or water-soluble fragrances.
Preferably, the amphiphilic polymer is sodium starch octenyl succinate and/or acacia; the outer wrapping layer contains cyclodextrin; the cyclodextrin is at least one selected from alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin. The application firstly adopts sodium starch octenyl succinate and/or acacia as the first coating layer, and plays a strong thickening and emulsifying role on essence. Wherein sodium starch octenyl succinate (trade name: pure gum, abbreviated as SSOS) is wrapped by combining hydrophobic alkenyl long-chain groups with essence, and hydrophilic carboxyl groups are combined with water to form a thicker interfacial film on the interface of water and oil, so that interfacial tension can be reduced, the dispersing effect of the essence in a system is promoted, and the complexation of the first wrapping layer by the subsequent cyclodextrin is facilitated; the first coating layer is coated by the cyclodextrin cavity to form a stable cyclodextrin complex serving as an outer coating layer, so that the stability of the complex is improved, and the effects of slow release, antioxidation, decomposition resistance, moisture resistance and the like can be provided. The double-layer wrapping structure of the sodium starch octenyl succinate and the cyclodextrin can ensure that essence is stably loaded in dental floss products, improve the storage stability of the flavoring composition, and can play an excellent slow-release effect in interdental environments to play a role in keeping fragrance for a long time; and the double-layer wrapping structure can be matched with various oil-soluble essences, so that the choice range of the essences is wide, and the adjustment of the flavor and taste is facilitated.
Preferably, the perfuming composition comprises the following raw materials in parts by weight: 5-60 parts of essence; 1-30 parts of amphiphilic polymer; 0.1-5 parts of cyclodextrin; 10-90 parts of water. The perfume compound has the advantages that the weight parts of the raw materials of all components are controlled, the perfume compound can be promoted to exert a better perfume enhancing effect, the perfume compound is stably wrapped by adopting the matching of the amphiphilic polymer and the cyclodextrin in proper proportion, and the sustained release effect and the stability of the perfume compound are improved.
Further, in order to ensure excellent matching effect of the wrapping layer, the flavoring composition comprises the following raw materials in parts by weight: 10-50 parts of essence; 1-20 parts of amphiphilic polymer; 0.1 to 0.4 part of cyclodextrin; 20-80 parts of water.
Preferably, at least part of the outer surface of the outer wrapper is covered with a second wrapper; the second coating layer contains gelatinized starch; the gelatinized starch is at least one selected from gelatinized glutinous rice starch, gelatinized waxy corn starch and gelatinized waxy sorghum starch. The gelatinized starch is adopted as the second wrapping layer, so that the bonding effect of the flavoring composition on dental floss products is enhanced, the flavoring composition can be stably attached to dental floss, and the stability of long-term storage can be further improved by matching the first wrapping layer with the outer wrapping layer, and the problem of falling powder is not easy to occur even in long-term storage. When the second parcel layer carries out full parcel to outer parcel layer, through the three-layer parcel structure of first parcel layer, outer parcel layer and second parcel layer mutually supporting, can further prevent that essence from volatilizing, being heated in long-time storage process from appearing, guarantee essence's save effect, can guarantee full fragrant smell when being used for between teeth to can exert excellent slowly-releasing effect under the interdental environment that constant temperature, high humidity and enzyme exist, realize remaining fragrance for a long time, optimize consumer's use experience.
Optionally, a second wrapping layer covers part of the outer surface of the outer wrapping layer, and the second wrapping layer wraps the outer wrapping layer locally; or, all outer surfaces of the outer wrapping layers are covered with second wrapping layers, and the second wrapping layers fully wrap the outer wrapping layers.
Optionally, the gelatinized starch is prepared by a process comprising the steps of: mixing starch with water, heating and gelatinizing to obtain gelatinized starch; the starch is at least one selected from glutinous rice starch, waxy corn starch and waxy sorghum starch.
Preferably, the perfuming composition comprises the following raw materials in parts by weight: 5-60 parts of essence; 1-30 parts of amphiphilic polymer; 0.1-5 parts of cyclodextrin; 10-90 parts of water; 1-10 parts of starch. The weight parts of the raw materials of the three wrapping layers are controlled, so that the wrapping effect of each wrapping layer in turn is improved, the slow release and lasting fragrance retaining capacity of the fragrance composition is improved, and the stability of the fragrance composition in long-term storage is improved.
Further, the perfuming composition comprises the following raw materials in parts by weight: 10-50 parts of essence; 1-4 parts of amphiphilic polymer; 0.1 to 0.4 part of cyclodextrin; 20-80 parts of water; 1-3 parts of starch.
Preferably, the perfuming composition further comprises a functional layer and other additives; the efficacy material layer is arranged between the first wrapping layer and the outer wrapping layer, and comprises efficacy materials; the flavoring composition comprises the following raw materials in parts by weight: 5-60 parts of essence; 1-30 parts of amphiphilic polymer; 0.1-5 parts of cyclodextrin; 10-90 parts of water; 1-10 parts of starch; 0.01 to 30 parts of efficacy substance; 0.1 to 50 portions of other additives. The functional material in the application refers to a component with a specific effect on tooth health care. The perfuming composition can carry various functional materials, and the functional material layer can carry out partial wrapping or complete wrapping on the first wrapping layer. The functional dental floss product is wrapped by the outer wrapping layer and the second wrapping layer, so that the stable storage and slow release effects of the functional product are ensured, the functional product can play a role in a lasting and stable manner, the cooperation of the weight components of the raw materials is beneficial to the maximization of the efficacy of the functional product between teeth, and the use effect of the functional dental floss product is optimized.
Preferably, the perfuming composition comprises the following raw materials in parts by weight: 10-50 parts of essence; 1-4 parts of amphiphilic polymer; 0.1 to 0.4 part of cyclodextrin; 20-80 parts of water; 1-3 parts of starch; 0.01 to 10 parts of efficacy substance; 0.1 to 30 parts of other additives.
The application discloses an intervention formula tooth seam cleaning product, the technical scheme who adopts is as follows:
an interposed slot cleaning product comprising: a cleaning member for extending into the slot; the cleaning member includes a cleaning main body; the cleaning body contains any one of the above-described fragrance imparting compositions. The perfuming composition can be positioned on the surface and/or inside the cleaning member, for example, the perfuming composition is positioned in a coating coated on the surface of the cleaning body, or the perfuming composition can be mixed with the raw materials of the cleaning body to prepare the cleaning body, so that the perfuming composition is positioned on the surface and inside the cleaning body. According to the intervention type tooth seam cleaning product, the aroma composition wrapped by the capsules is loaded, so that the initial concentration of the aroma and/or the cool feel is high in use, and the aroma is kept for a long time; and the essence has higher stability in long-term storage, solves the problem that the essence is easy to fall off, and can ensure higher fragrance concentration after long-term storage.
Preferably, the interventional slit cleaning product comprises any one of a dental floss stick, a dental floss roll, a interdental brush or a toothpick.
The capsule-wrapped perfuming composition and the intervention type tooth seam cleaning product loaded with the perfuming composition provided by the application enable the essence to have good slow-release effect when being applied in tooth seams through the cooperation of the microcapsule structures of the first wrapping layer and the outer wrapping layer, and the initial concentration of fragrance and/or cool feeling is high, and fragrance is kept for a long time; the slow release effect of the coating layer structure is also beneficial to stably maintaining the application concentration of the functional components in the tooth gaps and long-lasting efficacy; the adhesive capacity of the flavoring composition on dental floss products is improved by matching with the second wrapping layer of gelatinized starch, the long-term storage stability is ensured, the problem that the dental floss essence is easy to fall off is solved, the flavoring composition is matched with the first wrapping layer and the outer wrapping layer together, the problems of original volatile and poor thermal stability of the essence are overcome, and the higher fragrance concentration can be ensured after long-term storage; in addition, the microcapsule coating structure firstly adopts the amphiphilic polymer to thicken and emulsify the essence, can adapt to oil-soluble or water-soluble essence, has a large optional range for the essence, and is favorable for the allocation of flavor and taste.
Drawings
FIG. 1 is a schematic structural diagram of a perfuming composition in accordance with embodiments of the present application;
FIG. 2 is a graph showing apparent photographic results of plaque removal effects in test example 4;
FIG. 3 is a chart showing plaque development in a volunteer using a dental floss stick;
FIG. 4 is a chart showing plaque development in volunteers after one week of continued use of the floss product of example 8;
in the figure: 1-essence; 2-an efficacy layer; 101-a first wrapping layer; 102-an outer casing; 103-second wrapping layer.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application will be described in further detail with reference to specific embodiments. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the present application.
For simplicity, only a few numerical ranges are explicitly disclosed in this application. However, any lower limit may be combined with any upper limit to form a range not explicitly recited; and any lower limit may be combined with any other lower limit to form a range not explicitly recited, and any upper limit may be combined with any other upper limit to form a range not explicitly recited. Furthermore, each point or individual value between the endpoints of the range is included within the range, although not explicitly recited. Thus, each point or individual value may be combined as a lower or upper limit on itself with any other point or individual value or with other lower or upper limit to form a range that is not explicitly recited.
The essence in the prior art has the problems of easy volatilization and poor thermal stability, has poor storage stability, can not keep fragrance for a long time when being applied between teeth, and can easily cause the problem of powder falling after long-time storage of the dental floss product due to poor loading performance of the dental floss product on the essence.
In order to solve the above problems, the present application provides a capsule-encapsulated perfuming composition comprising an essence core and an outer coating; the essence inner core contains essence and a first wrapping layer wrapping the surface of the essence; the first encapsulation layer includes an amphiphilic polymer.
Illustratively, the amphiphilic compound has a lipophilic long chain alkenyl group and a hydrophilic carboxyl group. As used herein, long chain alkenyl refers to a group obtained by removing one or more hydrogen atoms from an olefin molecule having at least 6 carbon atoms.
The essence in the application refers to a complex mixture with specific aroma and/or flavor prepared from spice and/or spice auxiliary materials specified by essence and spice terminology (GB/T21171-2018), preferably food essence or essence for contacting oral cavity and lips with certain cool feeling, for example, at least one of peppermint essence, jasmine essence, grapefruit essence, sage essence, lemon essence, strawberry essence and banana essence; or food essence or oral cavity and lip contacting essence and cooling agent, wherein the cooling agent is at least one selected from Evercool 180, ws-3, ws-5, ws-23, menthol and oleum Menthae Dementholatum.
Optionally, the amphiphilic polymer is sodium starch octenyl succinate and/or acacia; the outer wrapping layer contains cyclodextrin; the cyclodextrin is at least one selected from alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin.
Sodium Starch Octenyl Succinate (SSOS) is used as an ionic surfactant, hydrophilic carboxylic acid groups are combined with water, and lipophilic alkenyl long chains are combined with oil-soluble essence in an oil-water mixed system of essence and water. Unlike small molecule emulsifier, the sodium starch octenyl succinate has thicker interfacial film formed at the interface between oil and water, and has greatly lowered interfacial tension and free energy, and the essence has the same negative charge to produce rejection effect, so that the emulsion system of essence and water has excellent stability. Meanwhile, the sodium starch octenyl succinate has higher viscosity and good viscosity stability, and is also beneficial to improving the stability of an emulsifying system. In addition, the emulsification system of the essence and water formed by the sodium starch octenyl succinate can be better matched with cyclodextrin, and the sodium starch octenyl succinate forms a stable complex with the cyclodextrin after wrapping the essence, so that a two-layer wrapping structure of the essence is obtained, the storage stability is better, and the slow release effect of the essence is promoted.
Beta-cyclodextrin is a non-reducing white crystalline powder, is odorless, can be well crystallized in aqueous solution and alcohol aqueous solution, forms crystalline inclusion compound with organic compound, and can also form inclusion compound with inorganic matter such as halogen.
Optionally, at least part of the outer surface of the outer wrapper is covered with a second wrapper; the second coating layer contains gelatinized starch.
Optionally, a second wrapping layer covers part of the outer surface of the outer wrapping layer, and the second wrapping layer wraps the outer wrapping layer locally; or, all outer surfaces of the outer wrapping layers are covered with second wrapping layers, and the second wrapping layers fully wrap the outer wrapping layers.
Preferably, the amylopectin content in the gelatinized starch is more than or equal to 80wt%. By controlling the mass proportion of the amylopectin in the gelatinized starch, the swelling effect and the gelatinization degree of the starch gelatinization are improved, the hydrogen bond in the amylopectin is broken after gelatinization, starch particles are broken and dispersed, the dispersed viscous micromolecule is spherical into a hydrocolloid network, and the adhesion is improved through Van der Waals force, hydrogen bond, crosslinking and the like. The gelatinized starch with amylopectin content of more than or equal to 80wt% can be at least one selected from gelatinized glutinous rice starch, gelatinized waxy corn starch and gelatinized waxy sorghum starch.
Illustratively, the gelatinized starch is prepared by a process comprising the steps of: mixing starch and water, heating to 70-85 ℃ and carrying out gelatinization treatment to obtain the gelatinized starch. The starch is at least one selected from glutinous rice starch, waxy corn starch and waxy sorghum starch.
Illustratively, the waxy starch is provided by a water-milled waxy flour. The amylopectin content of the glutinous rice flour is more than 80%, and the glutinous rice flour also contains rich nutrition including protein, fat, sugar, calcium, phosphorus, iron, vitamin B1, vitamin B2, nicotinic acid, starch and the like, and does not cause any influence on health when being applied to tooth gap cleaning products. In the process of heating and gelatinizing, starch particles firstly undergo an endothermic water absorption rapid expansion process, when the expansion process reaches a limit, hydrogen bonds in amylopectin are broken, the starch particles are broken and dispersed to form single molecules surrounded by water, and the dispersed viscous small molecular spheres form a hydrocolloid network and are bonded through Van der Waals force, hydrogen bonds and the like in a crosslinking manner, so that the glutinous rice flour has higher viscosity.
In some embodiments, the gelatinized starch is pregelatinized starch or high temperature gelatinized starch.
Illustratively, the pregelatinized starch is provided by pregelatinized waxy starch. The pregelatinized glutinous rice starch is particles obtained by rapid dehydration and drying after the glutinous rice starch is gelatinized, and can be directly dissolved in cold water to form a hydrocolloid network.
Illustratively, the high temperature gelatinized starch is provided by high temperature gelatinized glutinous rice starch. The high-temperature gelatinized glutinous rice starch is obtained by mixing glutinous rice starch with water, heating to gelatinization temperature, and gelatinizing. Compared with pregelatinized starch, the high-temperature gelatinized starch has higher quantity of hydroxyl functional groups released by amylopectin particles, can form a denser hydrocolloid network with water, and has excellent adhesive property.
Optionally, the perfuming composition further comprises a efficacy layer and other additives; the efficacy material layer is arranged between the first wrapping layer and the outer wrapping layer, and comprises efficacy materials; the functional material is at least one selected from an abrasive, a desensitizing agent, an antibacterial agent, a halitosis removing agent, a gingival bleeding preventing agent, a caries preventing agent, a periodontal disease preventing agent and a tartar preventing agent.
Illustratively, the efficacy substance may be selected from at least one of sodium phytate, sodium fluoride, chitosan, aloe vera extract.
Figure 1 shows a schematic structural diagram of a capsule-encapsulated perfuming composition of the present application, comprising an inner core of perfume, an efficacy layer and an outer casing layer; the essence core comprises essence 1 and a first wrapping layer 101 arranged on the outer side of the essence 1; the efficacy layer 2 is arranged between the first wrapping layer 101 and the outer wrapping layer 102, and the second wrapping layer 103 is covered on the whole outer surface of the outer wrapping layer 102.
In some exemplary embodiments, the perfuming composition comprises a fragrance inner core and an outer casing; the essence inner core contains essence and a first wrapping layer wrapping the surface of the essence; the first coating layer contains sodium starch octenyl succinate; the outer casing comprises beta-cyclodextrin. The perfuming composition comprises the following raw materials in parts by weight: 5-60 parts of essence; 1-30 parts of sodium starch octenyl succinate; 0.1 to 5 parts of beta-cyclodextrin; 10-90 parts of water.
In some exemplary embodiments, the perfuming composition comprises a fragrance inner core and an outer casing; the essence inner core contains essence and a first wrapping layer wrapping the surface of the essence; the first coating layer contains sodium starch octenyl succinate; the outer casing comprises beta-cyclodextrin; the whole outer surface of the outer wrapping layer is covered with a second wrapping layer; the second coating layer contains gelatinized glutinous rice starch. The perfuming composition comprises the following raw materials in parts by weight: 5-60 parts of essence; 1-30 parts of sodium starch octenyl succinate; 0.1 to 5 parts of beta-cyclodextrin; 10-90 parts of water; 1-10 parts of glutinous rice starch.
In some exemplary embodiments, the perfuming composition comprises a fragrance core, a efficacy layer, other additives, and an outer casing layer; the essence inner core contains essence and a first wrapping layer wrapping the surface of the essence; the first coating layer contains sodium starch octenyl succinate; the efficacy material layer is arranged between the first wrapping layer and the outer wrapping layer and is used for wrapping the first wrapping layer completely; the outer casing comprises beta-cyclodextrin. The perfuming composition comprises the following raw materials in parts by weight: 5-60 parts of essence; 1-30 parts of sodium starch octenyl succinate; 0.1 to 5 parts of beta-cyclodextrin; 10-90 parts of water; 0.01 to 30 parts of efficacy substance; 0.1 to 50 portions of other additives.
In some exemplary embodiments, the perfuming composition comprises a fragrance core, a efficacy layer, other additives, and an outer casing layer; the essence inner core contains essence and a first wrapping layer wrapping the surface of the essence; the first coating layer contains sodium starch octenyl succinate; the efficacy material layer is arranged between the first wrapping layer and the outer wrapping layer and is used for wrapping the first wrapping layer completely; the outer casing comprises beta-cyclodextrin; the whole outer surface of the outer wrapping layer is covered with a second wrapping layer; the second coating layer contains gelatinized glutinous rice starch. The perfuming composition comprises the following raw materials in parts by weight: 5-60 parts of essence; 1-30 parts of sodium starch octenyl succinate; 0.1 to 5 parts of beta-cyclodextrin; 10-90 parts of water; 1-10 parts of glutinous rice starch; 0.01 to 30 parts of efficacy substance; 0.1 to 50 portions of other additives.
The application also provides a preparation method of the capsule-coated perfuming composition, which comprises the following steps:
the preparation method of the capsule-coated perfuming composition comprises the following steps: 1) Mixing essence, amphiphilic polymer and water for emulsification to obtain a first system; 2) And adding cyclodextrin into the first system to carry out complexation reaction to obtain a second system, and thus obtaining the capsule-coated perfuming composition. According to the preparation method of the capsule-coated perfuming composition, the dispersion system of the essence in water is emulsified through the sodium starch octenyl succinate, the first layer of the essence is coated by the sodium starch octenyl succinate to obtain the essence core, the cyclodextrin and the essence core are adopted to be complexed to form a stable cyclodextrin complex, the essence core is coated, the volatilization problem of the essence is avoided, the filled fragrance is ensured when the capsule-coated perfuming composition is used, the slow release effect can be exerted among teeth, and the effect of long-lasting fragrance retention is realized.
The preparation method of the capsule-coated perfuming composition further comprises the following steps: adding gelatinized starch to the second system obtained in step 2) to obtain a third system. According to the preparation method of the interventional type tooth gap cleaning product, the external wrapping layer is wrapped by gelatinized starch, so that the three-layer wrapping structure matched with each other is formed, the stability of the perfuming composition in long-term storage can be improved, and the problem of falling off and powder falling is solved.
Optionally, step 1) further comprises adding an efficacy ingredient to the first system.
In some embodiments, the cyclodextrin is provided by a cyclodextrin solution and the gelatinized starch is provided by a gelatinized starch paste; the gelatinized starch paste is a mixed system of starch and water.
The present application also provides an interventional slot cleaning product comprising: a cleaning member for extending into the slot; the cleaning member includes a cleaning main body; the cleaning body contains any one of the above-described fragrance imparting compositions.
The application also provides a preparation method of any one of the intervention type tooth gap cleaning products, which comprises the following steps: the third system obtained in the preparation method of the capsule-coated perfuming composition is coated on the cleaning member body or mixed with the raw materials of the cleaning member to prepare the interventional tooth seam cleaning product.
Alternatively, the perfuming composition can be located in the coating layer on the surface of the cleaning member, or can be mixed with the raw material of the cleaning member during preparation for preparing the cleaning member, and distributed on the surface and inside the cleaning member.
An interventional slit cleaning product in this application refers to a product that partially or fully extends into the slit canal to clean and/or care teeth or gums, as opposed to a non-interventional slit cleaning product such as a dental floss. Illustratively, the intervening slot cleaning product may be selected from any of a dental floss product, a interdental brush product, a toothpick product. The dental floss product may be a dental floss stick or a dental floss roll.
In some exemplary embodiments, the dental floss product comprises dental floss; the dental floss comprises a dental floss body and a functional coating covering the dental floss body; the functional coating contains a perfuming composition; the perfuming composition comprises an essence inner core and an outer wrapping layer; the essence inner core contains essence and a first wrapping layer wrapping the surface of the essence; the first coating layer contains sodium starch octenyl succinate; the outer casing comprises beta-cyclodextrin. The perfuming composition comprises the following raw materials in parts by weight: 5-60 parts of essence; 1-30 parts of sodium starch octenyl succinate; 0.1 to 5 parts of beta-cyclodextrin; 10-90 parts of water.
In some exemplary embodiments, the dental floss product comprises dental floss; the dental floss comprises a dental floss body and a functional coating covering the dental floss body; the functional coating contains a perfuming composition; the perfuming composition comprises an essence inner core and an outer wrapping layer; the essence inner core contains essence and a first wrapping layer wrapping the surface of the essence; the first coating layer contains sodium starch octenyl succinate; the outer casing comprises beta-cyclodextrin; the whole outer surface of the outer wrapping layer is covered with a second wrapping layer; the second coating layer contains gelatinized glutinous rice starch. The perfuming composition comprises the following raw materials in parts by weight: 5-60 parts of essence; 1-30 parts of sodium starch octenyl succinate; 0.1 to 5 parts of beta-cyclodextrin; 10-90 parts of water; 1-10 parts of glutinous rice starch.
In some exemplary embodiments, the dental floss product comprises dental floss; the dental floss comprises a dental floss body and a functional coating covering the dental floss body; the functional coating contains a perfuming composition; the perfuming composition comprises an essence inner core, a functional material layer, other additives and an outer wrapping layer; the essence inner core contains essence and a first wrapping layer wrapping the surface of the essence; the first coating layer contains sodium starch octenyl succinate; the efficacy material layer is arranged between the first wrapping layer and the outer wrapping layer and is used for wrapping the first wrapping layer completely; the outer casing comprises beta-cyclodextrin. The perfuming composition comprises the following raw materials in parts by weight: 5-60 parts of essence; 1-30 parts of sodium starch octenyl succinate; 0.1 to 5 parts of beta-cyclodextrin; 10-90 parts of water; 0.01 to 30 parts of efficacy substance; 0.1 to 50 portions of other additives.
In some exemplary embodiments, the dental floss product comprises dental floss; the dental floss comprises a dental floss body and a functional coating covering the dental floss body; the functional coating contains a perfuming composition; the perfuming composition comprises an essence inner core, a functional material layer, other additives and an outer wrapping layer; the essence inner core contains essence and a first wrapping layer wrapping the surface of the essence; the first coating layer contains sodium starch octenyl succinate; the efficacy material layer is arranged between the first wrapping layer and the outer wrapping layer and is used for wrapping the first wrapping layer completely; the outer casing comprises beta-cyclodextrin; the whole outer surface of the outer wrapping layer is covered with a second wrapping layer; the second coating layer contains gelatinized glutinous rice starch. The perfuming composition comprises the following raw materials in parts by weight: 5-60 parts of essence; 1-30 parts of sodium starch octenyl succinate; 0.1 to 5 parts of beta-cyclodextrin; 10-90 parts of water; 1-10 parts of glutinous rice starch; 0.01 to 30 parts of efficacy substance; 0.1 to 50 portions of other additives.
Examples
The following description of the technical scheme of the present application is made with reference to specific examples, all of which are derived from common commercial raw materials.
Example 1
The dental floss product of the present embodiment comprises dental floss; the dental floss comprises a dental floss body and a functional coating covering the dental floss body; the functional coating contains a capsule-encapsulated perfuming composition; the capsule-encapsulated perfuming composition of this embodiment comprises an inner core of perfume and an outer coating; the essence inner core contains essence and a first wrapping layer wrapping the surface of the essence; wherein the essence is peppermint essence; the first coating layer contains sodium starch octenyl succinate; the outer casing comprises beta-cyclodextrin; the whole outer surface of the outer wrapping layer is covered with a second wrapping layer; the second coating layer contains gelatinized glutinous rice starch. The perfuming composition comprises the following raw materials in parts by weight: 25 parts of mint essence, 10 parts of sodium starch octenyl succinate, 0.25 part of beta-cyclodextrin, 1.6 parts of glutinous rice starch and 63.15 parts of water.
The preparation method of the dental floss product comprises the following steps:
1) Mixing essence, sodium starch octenyl succinate and water for emulsification to obtain a first system;
2) Dissolving beta-cyclodextrin in water to prepare saturated beta-cyclodextrin aqueous solution, adding the beta-cyclodextrin aqueous solution into the first system, and stirring to carry out complexation reaction to obtain a second system;
3) Mixing glutinous rice starch in water, heating to 70-85 ℃ for gelatinization to obtain gelatinized glutinous rice starch, adding gelatinized glutinous rice starch into the second system, and fully stirring to obtain a third system, thus obtaining the capsule-wrapped flavoring composition of the embodiment;
4) And (3) coating the third system obtained in the step (3) on a dental floss body, and drying to obtain the dental floss product of the embodiment.
Example 2
The dental floss product of this example differs from example 1 only in that: in the capsule-encapsulated perfuming composition of this embodiment, the weight parts of the raw materials of the components of the perfuming composition are: 10 parts of mint essence, 2 parts of sodium starch octenyl succinate, 0.1 part of beta-cyclodextrin, 1 part of glutinous rice starch and 86.9 parts of water.
Example 3
The dental floss product of this example differs from example 1 only in that: in the capsule-encapsulated perfuming composition of this embodiment, the weight parts of the raw materials of the components of the perfuming composition are: 50 parts of mint essence, 15 parts of sodium starch octenyl succinate, 0.4 part of beta-cyclodextrin, 3 parts of glutinous rice starch and 31.6 parts of water.
Example 4
The dental floss product of this example differs from example 1 only in that: in the capsule-wrapped perfuming composition of the present embodiment, a portion of the outer surface of the outer wrapping layer is covered with a second wrapping layer; the perfuming composition comprises the following raw materials in parts by weight: 60 parts of mint essence, 20 parts of sodium starch octenyl succinate, 5 parts of beta-cyclodextrin, 10 parts of glutinous rice starch and 5 parts of water.
Example 5
The dental floss product of this example differs from example 1 only in that: in the capsule-encapsulated perfuming composition of this embodiment, the weight parts of the raw materials of the components of the perfuming composition are: 5 parts of mint essence, 1 part of sodium starch octenyl succinate, 1 part of beta-cyclodextrin, 4 parts of glutinous rice starch and 89 parts of water.
Example 6
The dental floss product of this example differs from example 1 only in that: in the capsule-encapsulated perfuming composition of this example, gelatinized corn starch was used instead of gelatinized glutinous rice starch as the second coating layer, and the amylopectin content in the gelatinized corn starch was 60%.
Example 7
The dental floss product of this example differs from example 1 only in that: in the capsule-encapsulated perfuming composition of this example, the second encapsulation layer was not employed and a cellulose gum was employed as the adhesive.
The process for preparing the dental floss product of this example differs from example 1 only in that: and adding cellulose gum into the second system, fully stirring, coating on the dental floss body, and drying to obtain the dental floss product of the embodiment.
Example 8
The dental floss product of the present embodiment comprises dental floss; the dental floss comprises a dental floss body and a functional coating covering the dental floss body; the functional coating contains a capsule-encapsulated perfuming composition; the capsule-wrapped perfuming composition of the embodiment comprises an essence inner core, an efficacy layer and an outer wrapping layer; the essence inner core contains essence and a first wrapping layer wrapping the surface of the essence; wherein the essence is jasmine essence; the first coating layer contains sodium starch octenyl succinate; the efficacy material layer is arranged between the first wrapping layer and the outer wrapping layer, the first wrapping layer is fully wrapped, and the efficacy material is sodium phytate; the outer casing comprises beta-cyclodextrin; the whole outer surface of the outer wrapping layer is covered with a second wrapping layer; the second coating layer contains gelatinized glutinous rice starch. The perfuming composition comprises the following raw materials in parts by weight: 25 parts of jasmine essence, 10 parts of sodium starch octenyl succinate, 0.25 part of beta-cyclodextrin, 1.6 parts of glutinous rice starch, 0.25 part of functional substance (sodium phytate) and 62.9 parts of water.
The preparation method of the dental floss product comprises the following steps:
1) Mixing essence, sodium starch octenyl succinate and water for emulsification to obtain a first system, and then adding functional components into the first system;
2) Dissolving beta-cyclodextrin in water to prepare saturated beta-cyclodextrin aqueous solution, adding the beta-cyclodextrin aqueous solution into the first system, and stirring to carry out complexation reaction to obtain a second system;
3) Mixing glutinous rice starch in water, heating to 70-85 ℃ for gelatinization to obtain gelatinized glutinous rice starch, adding gelatinized glutinous rice starch into the second system, and fully stirring to obtain a third system;
4) And 3) adding sodium benzoate into the third system obtained in the step 3), uniformly mixing, coating the mixture on dental floss, and drying to obtain the dental floss product of the embodiment.
Example 9
The dental floss product of this example differs from example 8 only in that: in the capsule-encapsulated perfuming composition of this embodiment, the weight parts of the raw materials of the components of the perfuming composition are: 10 parts of grapefruit essence, 2 parts of sodium starch octenyl succinate, 0.1 part of beta-cyclodextrin, 1 part of glutinous rice starch, 0.05 part of efficacy substance (NaF) and 86.85 parts of water.
Example 10
The dental floss product of this example differs from example 8 only in that: in the capsule-encapsulated perfuming composition of this embodiment, the weight parts of the raw materials of the components of the perfuming composition are: 50 parts of sage essence, 20 parts of sodium starch octenyl succinate, 0.4 part of beta-cyclodextrin, 3 parts of glutinous rice starch, 1 part of efficacy substance (chitosan) and 25.6 parts of water.
Example 11
The dental floss product of this example differs from example 8 only in that: in the capsule-wrapped perfuming composition of the present embodiment, a portion of the outer surface of the outer wrapping layer is covered with a second wrapping layer; the perfuming composition comprises the following raw materials in parts by weight: 60 parts of strawberry essence, 10 parts of sodium starch octenyl succinate, 5 parts of beta-cyclodextrin, 10 parts of glutinous rice starch, 3 parts of efficacy (aloe extract) and 12 parts of water.
Example 12
The dental floss product of this example differs from example 8 only in that: in the capsule-encapsulated perfuming composition of this embodiment, the weight parts of the raw materials of the components of the perfuming composition are: 5 parts of banana essence, 5 parts of sodium starch octenyl succinate, 1 part of beta-cyclodextrin, 4 parts of glutinous rice starch, 10 parts of efficacy substance (aloe extract) and 75 parts of water.
Example 13
The dental floss product of this example differs from example 8 only in that: in the capsule-encapsulated perfuming composition of this example, the second encapsulation layer was not employed and a cellulose gum was employed as the adhesive.
Example 14
The dental floss product of this example differs from example 1 only in that: in the capsule-encapsulated perfuming composition of this example, acacia is used to replace sodium starch octenyl succinate in the first encapsulation layer.
Comparative example 1
The dental floss product of this comparative example differs from example 1 only in that: in the capsule-coated perfuming composition of this comparative example, the perfuming composition comprises a core, a first coating layer and a second coating layer which are sequentially arranged from inside to outside; the first coating layer comprises sodium starch octenyl succinate and cyclodextrin complex, and the second coating layer comprises gelatinized glutinous rice starch; the preparation method comprises the steps of mixing sodium starch octenyl succinate, cyclodextrin and water, adding essence, uniformly stirring to obtain a mixed system, and adding gelatinized glutinous rice starch into the mixed system to obtain the flavoring composition.
The raw material formulations of each example and comparative example are shown in table 1.
TABLE 1
Test example 1
The flavor retention performance of the flosses of examples 1 to 5, 14 and comparative example 1 during use was examined, wherein the flosses were scored and evaluated after use by a test team consisting of 20 persons for flavor intensity and cool feeling intensity (7 to 10 points: strong flavor; 5 to 6 points: strong flavor; 2 to 4 points: weak flavor; 1 point: weak flavor), and the results are shown in Table 2 below.
Table 2 results of fragrance retention properties of examples 1 to 5, 14 and comparative example 1
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As can be seen from Table 2, the flavor intensity and cool feeling intensity of the dental floss products of examples 1 to 5 can reach 5 to 10 minutes, and the dental floss products can also feel obvious cool taste and flavor after picking 3 to 8 teeth on average, wherein the second wrapping layer is adopted to cover the outer wrapping layer in example 4, and the lasting flavor retaining effect of 7 to 8 teeth can also be achieved, which indicates that the flavoring composition of the application has better slow release and lasting flavor retaining effect between teeth through the cooperation of the essence inner core and the outer wrapping layer structure; in the example 14, the sodium starch octenyl succinate is replaced by the Arabic gum, and compared with the example 1 with the same essence dosage, the higher fragrance intensity and cool feeling intensity can be achieved at first, but the fragrance and cool feeling are released rapidly in the interdental environment, and the obvious fragrance and cool feeling are difficult to feel after 4 teeth are removed on average, so that the sodium starch octenyl succinate can be matched with cyclodextrin, the slow release effect of the essence is further improved, and the lasting fragrance is promoted; in comparative example 1, the mixture of sodium starch octenyl succinate and cyclodextrin is used for forming a coating layer, the persistence of the flavor and the cool feeling is poorer, and 3 teeth are averagely removed to lose obvious flavor and cool feeling, thus reflecting the advantage of the two-layer coating structure for improving the slow release effect.
Test example 2
The storage stability of the dental flosses of examples 1 to 5 was examined, and the flavor intensity of the dental flosses at the beginning and after one, two and three months of storage was measured, respectively, and the measurement results are shown in Table 3 below.
TABLE 3 fragrance intensity after storage test results for examples 1-5
As can be seen from Table 3, the initial flavor intensity of the dental floss of examples 1 to 5 can reach 5 to 10 minutes, the flavor intensity can be maintained at 3 to 8 minutes after three months of storage, and a certain flavor is still provided.
Test example 3
The dental floss products prepared in examples 1, 6, 7 and 13 were examined for storage stability, powder falling degree, flavor property, cool feeling property and use effect, and the results are shown in table 4.
Table 4 results of performance investigation of example 1, example 6, example 7 and example 13
As is clear from Table 4, the initial flavor intensity and cool feeling intensity of the dental floss products of examples 1, 6, 7 and 13 were 8 minutes or more, and a good use experience was exhibited. Wherein, the dental floss of example 1 has no powder falling phenomenon in appearance after 3 months of storage, and the fragrance intensity and cool feeling intensity are slightly attenuated, but can still reach about 75-77.8% of the initial fragrance intensity and cool feeling intensity after three months, and the dental floss has excellent storage stability; the examples 7 and 13 using cellulose gum as the binder and the example 6 using corn starch as the binder also ensure strong initial fragrance intensity and cool feeling intensity, but slight powder falling occurs after one month of storage, obvious powder falling problems are visible after two and three months, and fragrance intensity is only 12.5 to 25% of the initial fragrance intensity before and during three months of use. For the lasting degree of fragrance and cool feeling, the dental floss of the embodiment 1 ensures a better slow release effect at the beginning, the lasting effect is improved by 33% compared with the dental floss of the embodiment 6, the embodiment 7 and the embodiment 13, the lasting effect is more than 6 times of that of the embodiment 7 after three months of storage, and the moderate strong fragrance feeling can be maintained, so that the application has good slow release effect when the application is carried out in a tooth gap due to the fact that the essence is wrapped by the microcapsule structure of the first wrapping layer and the outer wrapping layer, the fragrance and/or cool feeling initial concentration is high, the fragrance is lasting, the long-term storage stability is ensured by adopting the cooperation of the gelatinized glutinous rice starch and the microcapsule structure, and the problem that the powder of the dental floss essence is easy to fall is solved.
Test example 4
The in vitro plaque removal effect of the dental floss of example 8 was tested using a commercially available dental floss stick with antibacterial effect as a control under the test conditions shown in table 5 below.
TABLE 5 example 8 plaque removal effect test conditions
FIG. 2 is a graph showing apparent photographic results of hydroxyapatite after scraping with the dental floss of example 8 and a commercially available dental floss stick. As can be seen from FIG. 2, both example 8 and the commercially available dental floss bars showed a significant plaque removal effect after scraping as compared to the NC group. The quantitative absorbance of each group of dental plaque was measured, the results are shown in table 6, and the apparent color difference of each group of dental plaque biofilm was measured, and the results are shown in table 7.
TABLE 6 quantitative absorbance summary of dental plaque
| Group of | Average value of | Standard deviation of | P value | Clearance rate% |
| BC | 1.403 | 0.256 | / | / |
| NC | 3.449 | 0.298 | 0.000## | / |
| Commercially available dental floss rod is transversely scraped for 1 time | 2.345 | 0.014 | 0.003** | 32.018 |
| Example 8 lateral scraping 1 pass | 1.842 | 0.038 | 0.000** | 46.600 |
| Commercially available dental floss rod is scraped longitudinally for 10 times | 3.167 | 0.021 | 0.178 | 8.178 |
| EXAMPLE 8 longitudinal scraping 10 times | 2.971 | 0.021 | 0.050* | 13.870 |
TABLE 7 summary of apparent chromatic aberration of dental plaque biofilm (ΔE values)
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From table 6, the total plaque was significantly reduced after the commercial dental floss bar and example 8 scraping compared to NC group, with plaque removal rates of 32.018% and 46.6% after transverse scraping and 8.178% and 13.870% after longitudinal scraping, respectively. As can be seen from Table 7, example 8 lateral color difference value 36.833, and the commercially available dental floss bar lateral color difference value 25.583, demonstrate that example 8 provides better plaque cleaning and greater plaque removal than the commercially available dental floss bar.
Test example 5
Figures 3 and 4 show the plaque development of the dental floss before and after one week of continuous use of example 8, respectively, wherein the plaque development of the dental floss of the volunteer before using the dental floss stick is shown in figure 3, the dental floss of example 8 is used after each night, the plaque development of the dental floss of the volunteer after one week of continuous use is shown in figure 4, and the plaque is significantly reduced after one week of use of the dental floss containing the perfuming composition of the present application, as can be seen from a comparison of figures 3 and 4.
The foregoing is merely specific embodiments of the disclosure, but the protection scope of the disclosure is not limited thereto, and any person skilled in the art can easily think about changes or substitutions within the technical scope of the disclosure, and it is intended to cover the scope of the disclosure. Accordingly, equivalent variations from the claims of the present disclosure are intended to be covered by this disclosure.
Claims (10)
1. A capsule-encapsulated perfuming composition, characterized in that it comprises an inner core of an essence and an outer coating;
the essence inner core contains essence and a first wrapping layer wrapping the surface of the essence;
the first encapsulation layer includes an amphiphilic polymer.
2. The perfuming composition of claim 1, wherein the perfume comprises an oil-soluble perfume;
The amphiphilic polymer is sodium starch octenyl succinate and/or acacia;
the outer wrapping layer contains cyclodextrin; the cyclodextrin is at least one selected from alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin.
3. A perfuming composition according to claim 2, characterized in that the perfuming composition comprises the following raw materials in parts by weight:
5-60 parts of essence;
1-30 parts of amphiphilic polymer;
0.1-5 parts of cyclodextrin;
10-90 parts of water.
4. A perfuming composition according to claim 3, characterized in that the perfuming composition comprises the following raw materials in parts by weight:
10-50 parts of essence;
1-20 parts of amphiphilic polymer;
0.1 to 0.4 part of cyclodextrin;
20-80 parts of water.
5. A perfuming composition according to claim 2, characterized in that at least part of the outer surface of the outer wrapping is covered with a second wrapping;
the second coating layer contains gelatinized starch; the gelatinized starch is at least one selected from gelatinized glutinous rice starch, gelatinized glutinous corn flour and gelatinized glutinous sorghum flour.
6. The perfuming composition of claim 5, wherein the perfuming composition comprises the following raw materials in parts by weight:
5-60 parts of essence;
1-30 parts of amphiphilic polymer;
0.1-5 parts of cyclodextrin;
10-90 parts of water;
1-10 parts of starch.
7. The perfuming composition of claim 6, wherein the perfuming composition comprises the following raw materials in parts by weight:
10-50 parts of essence;
1-20 parts of amphiphilic polymer;
0.1 to 0.4 part of cyclodextrin;
20-80 parts of water;
1-3 parts of starch.
8. The perfuming composition of claim 5 wherein the perfuming composition further comprises a functional layer and other additives;
the efficacy material layer is arranged between the first wrapping layer and the outer wrapping layer, and comprises efficacy materials;
the flavoring composition comprises the following raw materials in parts by weight:
5-60 parts of essence;
1-30 parts of amphiphilic polymer;
0.1-5 parts of cyclodextrin;
10-90 parts of water;
1-10 parts of starch;
0.01 to 30 parts of efficacy substance;
0.1 to 50 portions of other additives.
9. The perfuming composition of claim 8, wherein the perfuming composition comprises the following raw materials in parts by weight:
10-50 parts of essence;
1-20 parts of amphiphilic polymer;
0.1 to 0.4 part of cyclodextrin;
20-80 parts of water;
1-3 parts of starch;
0.01 to 10 parts of efficacy substance;
0.1 to 30 parts of other additives.
10. An interposed slot cleaning product, comprising: a cleaning member for extending into the slot;
the cleaning member includes a cleaning main body;
the cleaning body comprising a perfuming composition according to any one of claims 1 to 9;
the intervening gap cleaning product comprises any of a dental floss stick, a dental floss roll, a interdental brush, or a toothpick.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310638387.2A CN117598928A (en) | 2023-05-31 | 2023-05-31 | Capsule-wrapped perfuming composition and intervening type tooth gap cleaning product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310638387.2A CN117598928A (en) | 2023-05-31 | 2023-05-31 | Capsule-wrapped perfuming composition and intervening type tooth gap cleaning product |
Publications (1)
| Publication Number | Publication Date |
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| CN117598928A true CN117598928A (en) | 2024-02-27 |
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|---|---|---|---|
| CN202310638387.2A Pending CN117598928A (en) | 2023-05-31 | 2023-05-31 | Capsule-wrapped perfuming composition and intervening type tooth gap cleaning product |
Country Status (1)
| Country | Link |
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| CN (1) | CN117598928A (en) |
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