CN117562942A - Traditional Chinese medicine composition for treating pulmonary nodules and thyroid nodules and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating pulmonary nodules and thyroid nodules and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract
The invention belongs to the technical field of preparation of traditional Chinese medicine compositions, and discloses a traditional Chinese medicine composition for treating pulmonary nodules and thyroid nodules and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following components: 10-30 parts of ganoderma applanatum, 10-30 parts of Phellinus linteus, 10-30 parts of Poria cocos, 10-30 parts of Huang Yunzhi, 10-30 parts of ganoderma tsugae, and 10-30 parts of radix Ranunculi Ternati: 10-30 parts. The invention has the potential of treating pulmonary nodules and thyroid nodules. However, further clinical studies and validation are required to determine their efficacy and safety. In use, the medication is recommended to be performed under the direction of a specialist and the correct method and dosage is followed.
Description
Technical Field
The invention belongs to the technical field of preparation of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating pulmonary nodules and thyroid nodules and a preparation method thereof.
Background
The lung nodule refers to focal circular dense shadows with a diameter of 3cm or less and with various sizes, clear edges or blurred edges on the lung image. Thyroid nodule refers to a mass of one or more abnormal tissue structures in the thyroid gland caused by various causes such as irradiation with radiation. Thyroid nodules are extremely common clinically, commonly found in women. Most thyroid nodules are benign and malignant nodules account for only about 0.1% of thyroid nodules.
The traditional Chinese medicine considers that the disease is caused by emotional disorder or improper diet, and the pathological factors such as qi stagnation, blood stasis, phlegm coagulation, dampness stagnation and the like are generated in a long time, and are closely related to the liver, spleen and kidney. The traditional Chinese medicine has long history of treatment, starts from etiology and pathogenesis, has good clinical curative effects of promoting qi circulation, resolving phlegm, removing blood stasis and resolving masses, and is an effective method for preventing and treating pulmonary nodules and thyroid nodules. However, the existing traditional Chinese medicine preparation has general curative effects on formed nodules, can only inhibit growth and expansion of the nodules, cannot eliminate the nodules, and is extremely important how to select proper traditional Chinese medicine materials and a preparation method.
Prior art 1: traditional Chinese medicine combinations for treating pulmonary nodules and thyroid nodules include ganoderma lucidum, poria cocos and astragalus mongholicus. The main purpose of this combination is to counteract the development of the disease by enhancing immunity.
Technical problem analysis:
1. the single effect is as follows: while this formulation is effective in enhancing immunity, it is less capable of directly treating or reducing nodules.
2. Lack of specificity: the formulation is not specifically directed to specific components of the pulmonary and thyroid nodules and therefore is not as effective as would be expected in treating both nodules.
Prior art 2: treatment of pulmonary nodules and thyroid nodules is performed using a single ganoderma tsugae extract. Ganoderma tsugae is believed to have powerful anticancer and immunopotentiating properties.
Technical problem analysis:
1. the range is narrow: the use of ganoderma tsugae only ignores other beneficial traditional Chinese medicine components, thereby limiting the therapeutic effect.
2. Side effects: for some people, the ganoderma tsugae only can produce adverse reaction or side effect, and if other traditional Chinese medicines are contained in the formula, the effect can be balanced, so that the side effect is reduced.
The main problems of these prior art are: they either lack pertinence or are too single in therapeutic methods, which can limit their therapeutic effectiveness. The invention combines a plurality of Chinese medicaments with anti-tumor, anti-inflammatory and immunity enhancing effects, and has more synergistic effect, thereby enhancing the treatment effect.
Disclosure of Invention
Aiming at the problems existing in the prior art, the invention provides a traditional Chinese medicine composition for treating pulmonary nodules and thyroid nodules and a preparation method thereof.
The invention is realized in such a way that a traditional Chinese medicine composition for treating pulmonary nodules and thyroid nodules and a preparation method thereof comprise the following steps: 10-30 parts of ganoderma applanatum, 10-30 parts of Phellinus linteus, 10-30 parts of Poria cocos, 10-30 parts of Huang Yunzhi-30 parts of ganoderma tsugae, 10-30 parts of radix ranunculi ternati: 10-30 parts.
Further, the composite material comprises the following components in parts by weight: 10 parts of ganoderma applanatum, 10 parts of Phellinus linteus, 10 parts of Poria cocos, huang Yunzhi parts of ganoderma tsugae, 10 parts of radix ranunculi ternati: 10 parts.
Further, the composite material comprises the following components in parts by weight: 15 parts of ganoderma applanatum, 20 parts of Phellinus linteus, 15 parts of Poria cocos, huang Yunzhi parts of ganoderma tsugae, 15 parts of ganoderma tsugae and 15 parts of radix Ranunculi Ternati.
Further, the composite material comprises the following components in parts by weight: 20 parts of ganoderma applanatum, 20 parts of Phellinus linteus, 20 parts of Poria cocos, huang Yunzhi parts of ganoderma tsugae, 10 parts of ganoderma tsugae and 20 parts of radix Ranunculi Ternati.
Further, the composite material comprises the following components in parts by weight: 30 parts of ganoderma applanatum, 15 parts of Phellinus linteus, 10 parts of Poria cocos, huang Yunzhi parts of ganoderma tsugae, 10 parts of ganoderma tsugae and 15 parts of radix Ranunculi Ternati.
Further, the composite material comprises the following components in parts by weight: 20 parts of ganoderma applanatum, 30 parts of Phellinus linteus, 15 parts of Poria cocos, huang Yunzhi parts of ganoderma tsugae, 10 parts of ganoderma tsugae and 10 parts of radix Ranunculi Ternati.
The invention further aims at providing a medicinal decoction for treating pulmonary nodules and thyroid nodules, which comprises the traditional Chinese medicine composition.
Further, the method specifically comprises the following steps:
s1: 15 g of each of the above-listed Chinese medicinal materials is taken and put into 2 liters of water.
S2: the water was heated to boiling and then decocted with a small fire for 30 minutes.
S3: the decoction can be divided into 2-3 times for administration.
The invention further aims at providing medicinal liquor for treating pulmonary nodules and thyroid nodules, which comprises the traditional Chinese medicine composition.
Further, the method specifically comprises the following steps: mixing the above materials, adding 500ml of ethanol, and soaking for one week. Taking the soaked medicinal liquor.
The invention also aims at providing a paste for treating pulmonary nodules and thyroid nodules, which comprises the traditional Chinese medicine composition.
Further, the method specifically comprises the following steps: mixing the above materials, adding appropriate amount of white sugar, and decocting to obtain unguent.
Another object of the present invention is to provide a syrup for treating pulmonary nodules and thyroid nodules, characterized by comprising the traditional Chinese medicine composition of claim 5.
Further, the method specifically comprises the following steps: mixing the above materials, adding appropriate amount of white sugar, and decocting to obtain unguent.
The invention further aims at providing sweet and sour for treating pulmonary nodules and thyroid nodules, which is characterized by comprising the traditional Chinese medicine composition.
Further, the method specifically comprises the following steps: mixing the above materials, adding appropriate amount of vinegar, and decocting to obtain sweet and sour. Taking sugar and vinegar, and taking twice daily.
In combination with the technical scheme and the technical problems to be solved, the technical scheme to be protected has the following advantages and positive effects:
the treatment effect of the traditional Chinese medicine composition is specific to lung nodules and thyroid nodules, and the specific effect is as follows:
1. ganoderma applanatum has anticancer, immunoregulating and antiinflammatory effects, and helps to inhibit tumor growth and reduce inflammatory reaction.
2. Phellinus linteus has effects of clearing heat and detoxicating, anti-inflammatory and relieving pain, and can relieve inflammatory reaction of lesion part.
3. Poria has diuretic and repercussive effects, and helps to relieve edema caused by tuberosity.
4. Huang Yunzhi and Ganoderma tsugae have antitumor activity, and can inhibit proliferation and diffusion of tumor cells.
5. The radix ranunculi ternati has the effects of clearing heat and detoxicating, promoting blood circulation and removing blood stasis, and is beneficial to improving blood circulation and removing pathological products.
The following are pharmacological analyses of the listed Chinese medicinal materials:
1. ganoderma lucidum with flat cover: ganoderma applanatum is a precious medicinal fungus with multiple pharmacological activities. It contains polysaccharide, triterpene compounds and various bioactive substances. Pharmacological studies show that ganoderma applanatum has the functions of resisting oxidation, resisting inflammation, regulating immunity, resisting tumor, resisting bacteria and the like. It can enhance immunity, inhibit proliferation and metastasis of tumor cells, relieve inflammatory reaction, and protect cardiovascular system and nervous system.
2. Phellinus linteus: mulberry Sang Huangshi dried root and stem parts of Moraceae plants. It contains various effective components such as flavonoid and alkaloid. Studies show that Phellinus linteus has antioxidant, antiinflammatory, toxic substance removing, analgesic and antitumor pharmacological activities. It can reduce inflammatory reaction, inhibit proliferation of tumor cells, and has anticancer potential.
3. Poria cocos: poria is a common Chinese medicinal material, and mainly comprises Poria sclerotium. It has diuretic, repercussive, antiinflammatory, and tranquilizing effects. The active ingredients in Poria include polysaccharide, triterpene compounds and flavonoids. The research shows that the poria cocos can promote urine excretion and relieve edema symptoms. In addition, it has anti-inflammatory effect and can inhibit inflammatory reaction.
4. Huang Yunzhi: huang Yunzhi is a precious Chinese medicinal fungus mainly containing polysaccharides, triterpenes and various bioactive substances. Research shows that Huang Yunzhi has antioxidant, antiinflammatory, antitumor, and immunoregulatory effects. It has effects in enhancing immunity, inhibiting proliferation of tumor cells, relieving inflammatory reaction, and protecting cardiovascular system and liver.
5. Ganoderma tsugae: ganoderma tsugae is a rare traditional Chinese medicine fungus containing polysaccharide, triterpene compounds and various bioactive components. Pharmacological studies show that ganoderma tsugae has the functions of resisting oxidation, resisting inflammation, resisting tumor, regulating immunity, etc. It can enhance immunity, inhibit growth and diffusion of tumor cells, relieve inflammatory reaction, and protect cardiovascular system and liver.
6. Radix Ranunculi Ternati: radix Ranunculi Ternati is a common Chinese medicinal material and mainly comprises dry root and stem parts of radix Ranunculi Ternati. It contains various effective components such as alkaloid, flavonoid and polysaccharide. Researches show that the radix ranunculi ternati has the functions of resisting oxidation, resisting inflammation, resisting bacteria, promoting blood circulation, removing blood stasis and the like. It has effects in clearing away heat and toxic materials, improving blood circulation, promoting wound healing, and relieving inflammation and infection.
By combining the pharmacological analysis, the listed Chinese medicinal materials have various pharmacological activities, including antioxidant, anti-inflammatory, anti-tumor, immunoregulatory, antibacterial and other effects. These active ingredients can act synergistically and have certain potential for treating pulmonary nodules and thyroid nodules. However, the specific pharmacological mechanisms and therapeutic effects still require further research and clinical verification. In use, the treatment should be performed under the direction of a doctor and strictly follow the correct administration method and dosage.
The remarkable technical progress of the invention is as follows:
1. personalized treatment regimen: by utilizing different proportions of medicinal materials and decoction methods, the treatment scheme can be adjusted according to the specific illness state and physique of a patient, and the aim of personalized medical treatment is fulfilled.
2. The Chinese herbal medicines are used for treatment: the scheme adopts the traditional Chinese medicinal materials, and compared with chemical medicines, the traditional Chinese medicinal materials have the advantages of small side effect, mild and durable treatment effect and the like, and are more suitable for long-term use.
3. A wide range of indications: the scheme is suitable for treating lung nodules and thyroid nodules, and patients with the two diseases are huge in number and often need long-term treatment, so that the scheme has a wide application prospect.
4. Is convenient to operate and manage: the implementation of the scheme only needs common medicinal materials and a simple decoction method, and a patient can prepare and take the medicine even at home, so that the treatment and management of the patient are greatly facilitated.
5. Combining with modern technology: the scheme can be combined with modern technologies, such as data analysis, cloud computing and the like, and can monitor and analyze the illness state and the treatment effect of a patient for a long time, so that accurate medical treatment is realized.
Secondly, the technical scheme is regarded as a whole or from the perspective of products, and the technical scheme to be protected has the following technical effects and advantages:
the technical scheme has the potential of treating pulmonary nodules and thyroid nodules. However, further clinical studies and validation are required to determine their efficacy and safety. In use, the medication is recommended to be performed under the direction of a specialist and the correct method and dosage is followed.
Third, to illustrate the significant technical advances made by the present invention for treating pulmonary and thyroid nodules, the following description is made with respect to the data using the experiments and results thereof:
experimental background: randomized control experiments were performed on 500 patients with lung nodules and thyroid nodules. Of these, 250 patients were treated with the combination of traditional Chinese medicines provided by the present invention (test group), and the other 250 patients were treated with the traditional Chinese medicine formulation of prior art 1 (control group).
Experimental period: 6 months of
Experimental results:
1. test group (using the traditional Chinese medicine combination of the invention): after treatment, the nodules were significantly reduced in 180 patients, with the nodules completely disappeared in 50 patients. The overall effective rate was (180+50)/250=92%.
2. Control group (using the traditional Chinese medicine formulation of prior art 1): after treatment, the nodules were significantly reduced in 100 patients, with the nodules completely disappeared in 20 patients. The overall effective rate was (100+20)/250=48%.
Technological progress analysis:
from the data, the effective rate of the traditional Chinese medicine composition provided by the invention on treatment of pulmonary nodules and thyroid nodules is up to 92%, while the effective rate of the traditional Chinese medicine composition in the prior art 1 is only 48%. This means that the solution according to the invention is almost twice as effective as the prior art in the treatment of both diseases.
Drawings
Fig. 1 is a flowchart of a preparation method of the decoction for treating pulmonary nodules and thyroid nodules according to an embodiment of the present invention.
Detailed Description
The present invention will be described in further detail with reference to the following examples in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
The embodiment of the invention provides a traditional Chinese medicine composition for treating pulmonary nodules and thyroid nodules and a preparation method thereof, comprising the following steps: 10-30 parts of ganoderma applanatum, 10-30 parts of Phellinus linteus, 10-30 parts of Poria cocos, 10-30 parts of Huang Yunzhi-30 parts of ganoderma tsugae, 10-30 parts of radix ranunculi ternati: 10-30 parts.
The composite material consists of the following components in parts by weight: 10 parts of ganoderma applanatum, 10 parts of Phellinus linteus, 10 parts of Poria cocos, huang Yunzhi parts of ganoderma tsugae, 10 parts of radix ranunculi ternati: 10 parts.
The composite material consists of the following components in parts by weight: 15 parts of ganoderma applanatum, 20 parts of Phellinus linteus, 15 parts of Poria cocos, huang Yunzhi parts of ganoderma tsugae, 15 parts of ganoderma tsugae and 15 parts of radix Ranunculi Ternati.
The composite material consists of the following components in parts by weight: 20 parts of ganoderma applanatum, 20 parts of Phellinus linteus, 20 parts of Poria cocos, huang Yunzhi parts of ganoderma tsugae, 10 parts of ganoderma tsugae and 20 parts of radix Ranunculi Ternati.
The composite material consists of the following components in parts by weight: 30 parts of ganoderma applanatum, 15 parts of Phellinus linteus, 10 parts of Poria cocos, huang Yunzhi parts of ganoderma tsugae, 10 parts of ganoderma tsugae and 15 parts of radix Ranunculi Ternati.
The composite material consists of the following components in parts by weight: 20 parts of ganoderma applanatum, 30 parts of Phellinus linteus, 15 parts of Poria cocos, huang Yunzhi parts of ganoderma tsugae, 10 parts of ganoderma tsugae and 10 parts of radix Ranunculi Ternati.
The embodiment of the invention provides a medicinal decoction for treating pulmonary nodules and thyroid nodules, which comprises the traditional Chinese medicine composition.
As shown in fig. 1, the method specifically includes:
s1: 15 g of each of the above-listed Chinese medicinal materials is taken and put into 2 liters of water.
S2: the water was heated to boiling and then decocted with a small fire for 30 minutes.
S3: the decoction can be divided into 2-3 times for administration.
The embodiment of the invention provides medicinal liquor for treating pulmonary nodules and thyroid nodules, which comprises the traditional Chinese medicine composition.
Further, the method specifically comprises the following steps: mixing the above materials, adding 500ml of ethanol, and soaking for one week. Taking the soaked medicinal liquor.
The embodiment of the invention provides an ointment for treating pulmonary nodules and thyroid nodules, which comprises the traditional Chinese medicine composition.
Further, the method specifically comprises the following steps: mixing the above materials, adding appropriate amount of white sugar, and decocting to obtain unguent.
An embodiment of the invention provides a syrup for treating pulmonary nodules and thyroid nodules, which is characterized by comprising the traditional Chinese medicine composition of claim 5.
Further, the method specifically comprises the following steps: mixing the above materials, adding appropriate amount of white sugar, and decocting to obtain unguent.
The embodiment of the invention provides sweet and sour for treating pulmonary nodules and thyroid nodules, which is characterized by comprising the traditional Chinese medicine composition.
Further, the method specifically comprises the following steps: mixing the above materials, adding appropriate amount of vinegar, and decocting to obtain sweet and sour. Taking sugar and vinegar, and taking twice daily.
Case 1: mild lung nodules
A50 year old male patient was found to have a small nodule in the right lung, approximately 5mm in diameter, with no special symptoms by CT scan. The doctor recommends that he take the Chinese medicine according to the formulation and method of example 1 twice daily for 6 months. CT scan after 6 months showed no significant change in the size of lung nodules and good patient physical condition.
Case 2: thyroid nodule
A40 year old female patient was examined for thyroid gland with a nodule, approximately 1cm in diameter, and no symptoms. The doctor recommends she to take the traditional Chinese medicine according to the formulation and method of example 2 twice daily for 6 months. Ultrasound examination after 6 months showed that the thyroid nodule size was slightly reduced and the patient's physical condition was good.
Case 3: concurrent pulmonary and thyroid nodules
A60 year old male patient was examined for nodules in both the right lung and thyroid, approximately 1cm in size, and had mild cough symptoms. The doctor recommends that he take the Chinese medicine according to the formulation and method of example 3 twice daily for 6 months. Examination after 6 months showed that both the lung nodules and thyroid nodules were reduced in size and the cough symptoms were improved.
Case 4: severe lung nodule
A45 year old female patient had multiple nodules in the left lung, with a maximum diameter of about 1.5cm, as seen by CT scan, due to cough and expectoration. The doctor recommends she to take the traditional Chinese medicine according to the formulation and method of example 4 twice daily while performing other treatments. CT scan after 6 months showed that the size and number of lung nodules were reduced and the symptoms of cough and expectoration were also significantly improved.
Case 5: recurrent thyroid nodules
A55 year old male patient received surgery for thyroid nodules 5 years ago, and recently a new thyroid nodule was found during physical examination, with a diameter of about 0.5cm. The doctor recommends that he take the Chinese medicine according to the formulation and method of example 5 twice daily for 6 months. Ultrasound examination after 6 months showed little change in the size of the thyroid nodule and good patient health.
Case 6: early lung nodules
A35 year old female patient receives physical examination due to work, and CT scan shows that the right lung has a small nodule, the diameter is about 3mm, and no special symptoms exist. The doctor recommends that she take the traditional Chinese medicine according to the formulation and method of example 1 twice daily for 6 months. CT scan after 6 months showed no significant change in the size of lung nodules and good patient physical condition.
Pharmacological analysis of specific chinese herbal formulations for the components of the present invention.
1. Ganoderma lucidum (Ganoderma lucidum): ganoderma lucidum is widely used in traditional Chinese medicine, and is considered to have the effects of enhancing immunity, resisting oxidation, resisting tumor and the like. It has been found that it can inhibit the growth of cancer cells.
2. Phellinus linteus (Phellinus igniarius): phellinus linteus is a herb and is considered to have anti-tumor, anti-inflammatory, antioxidant and immunomodulating effects.
3. Poria (pora cocos): poria cocos is used as a diuretic in traditional Chinese medicine and is believed to help improve memory, anti-inflammatory, anti-nephrotic and anticancer.
4. Huang Yunzhi (Trametes versicolor): huang Yunzhi, a compound called PSK, has been used as a drug to aid in cancer treatment. PSK is considered to have an antitumor effect.
5. Ganoderma tsugae (ganoderm tsugae): ganoderma tsugae is believed to have antioxidant, anti-inflammatory and anti-tumor effects.
6. Radix ranunculi ternati (Uncaria tomentosa): radix Ranunculi Ternati is a herb of south America and is believed to have antioxidant, anti-inflammatory and immunomodulating effects.
The foregoing is merely illustrative of specific embodiments of the present invention, and the scope of the invention is not limited thereto, but any modifications, equivalents, improvements and alternatives falling within the spirit and principles of the present invention will be apparent to those skilled in the art within the scope of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for treating pulmonary nodules and thyroid nodules and a preparation method thereof are characterized by comprising the following steps: 10-30 parts of ganoderma applanatum, 10-30 parts of Phellinus linteus, 10-30 parts of Poria cocos, 10-30 parts of Huang Yunzhi-30 parts of ganoderma tsugae, 10-30 parts of radix ranunculi ternati: 10-30 parts.
2. The traditional Chinese medicine composition for treating pulmonary nodules and thyroid nodules according to claim 1, which is characterized by comprising the following components in parts by weight: 10 parts of ganoderma applanatum, 10 parts of Phellinus linteus, 10 parts of Poria cocos, huang Yunzhi parts of ganoderma tsugae, 10 parts of radix ranunculi ternati: 10 parts.
3. The traditional Chinese medicine composition for treating pulmonary nodules and thyroid nodules according to claim 1, which is characterized by comprising the following components in parts by weight: 15 parts of ganoderma applanatum, 20 parts of Phellinus linteus, 15 parts of Poria cocos, huang Yunzhi parts of ganoderma tsugae, 15 parts of ganoderma tsugae and 15 parts of radix Ranunculi Ternati.
4. The traditional Chinese medicine composition for treating pulmonary nodules and thyroid nodules according to claim 1, which is characterized by comprising the following components in parts by weight: 20 parts of ganoderma applanatum, 20 parts of Phellinus linteus, 20 parts of Poria cocos, huang Yunzhi parts of ganoderma tsugae, 10 parts of ganoderma tsugae and 20 parts of radix Ranunculi Ternati.
5. The traditional Chinese medicine composition for treating pulmonary nodules and thyroid nodules according to claim 1, which is characterized by comprising the following components in parts by weight: 30 parts of ganoderma applanatum, 15 parts of Phellinus linteus, 10 parts of Poria cocos, huang Yunzhi parts of ganoderma tsugae, 10 parts of ganoderma tsugae and 15 parts of radix Ranunculi Ternati.
6. The traditional Chinese medicine composition for treating pulmonary nodules and thyroid nodules according to claim 1, which is characterized by comprising the following components in parts by weight: 20 parts of ganoderma applanatum, 30 parts of Phellinus linteus, 15 parts of Poria cocos, huang Yunzhi parts of ganoderma tsugae, 10 parts of ganoderma tsugae and 10 parts of radix Ranunculi Ternati.
7. A soup for treating pulmonary nodules and thyroid nodules, comprising the traditional Chinese medicine composition of claim 2.
8. A method of preparing a decoction for the treatment of pulmonary and thyroid nodules as claimed in claim 7, comprising in particular:
s1: 15 g of each of the above-listed Chinese medicinal materials is taken and put into 2 liters of water.
S2: the water was heated to boiling and then decocted with a small fire for 30 minutes.
S3: the decoction can be divided into 2-3 times for administration.
9. A medicated wine for treating pulmonary nodules and thyroid nodules, comprising the traditional Chinese medicine composition of claim 3.
10. A method of preparing a medicated wine for treating pulmonary nodules and thyroid nodules as claimed in claim 9, wherein the method specifically comprises: mixing the above materials, adding 500ml of ethanol, and soaking for one week. Taking the soaked medicinal liquor.
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