CN117546867A - Soluble granule of glufosinate-ammonium and preparation method thereof - Google Patents
Soluble granule of glufosinate-ammonium and preparation method thereof Download PDFInfo
- Publication number
- CN117546867A CN117546867A CN202311559679.3A CN202311559679A CN117546867A CN 117546867 A CN117546867 A CN 117546867A CN 202311559679 A CN202311559679 A CN 202311559679A CN 117546867 A CN117546867 A CN 117546867A
- Authority
- CN
- China
- Prior art keywords
- ammonium
- glufosinate
- polyether
- sodium
- soluble granule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008187 granular material Substances 0.000 title claims abstract description 48
- IAJOBQBIJHVGMQ-UHFFFAOYSA-N 2-amino-4-[hydroxy(methyl)phosphoryl]butanoic acid Chemical compound CP(O)(=O)CCC(N)C(O)=O IAJOBQBIJHVGMQ-UHFFFAOYSA-N 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title description 7
- ZBMRKNMTMPPMMK-UHFFFAOYSA-N 2-amino-4-[hydroxy(methyl)phosphoryl]butanoic acid;azane Chemical compound [NH4+].CP(O)(=O)CCC(N)C([O-])=O ZBMRKNMTMPPMMK-UHFFFAOYSA-N 0.000 claims abstract description 37
- 229920000570 polyether Polymers 0.000 claims abstract description 37
- 239000004721 Polyphenylene oxide Substances 0.000 claims abstract description 31
- -1 dimethyl tertiary amine Chemical class 0.000 claims abstract description 25
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 22
- 239000003831 antifriction material Substances 0.000 claims abstract description 19
- 239000002253 acid Substances 0.000 claims abstract description 9
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 8
- 150000003839 salts Chemical class 0.000 claims abstract description 8
- 239000004094 surface-active agent Substances 0.000 claims abstract description 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 6
- XFRVVPUIAFSTFO-UHFFFAOYSA-N 1-Tridecanol Chemical compound CCCCCCCCCCCCCO XFRVVPUIAFSTFO-UHFFFAOYSA-N 0.000 claims abstract description 5
- 235000019864 coconut oil Nutrition 0.000 claims abstract description 5
- 239000003240 coconut oil Substances 0.000 claims abstract description 5
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 5
- 239000000194 fatty acid Substances 0.000 claims abstract description 5
- 229930195729 fatty acid Natural products 0.000 claims abstract description 5
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 5
- 229920001451 polypropylene glycol Polymers 0.000 claims abstract description 5
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 4
- 239000002518 antifoaming agent Substances 0.000 claims abstract description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 4
- 239000011787 zinc oxide Substances 0.000 claims abstract description 4
- 229920001661 Chitosan Polymers 0.000 claims abstract description 3
- 239000000945 filler Substances 0.000 claims abstract description 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229920000909 polytetrahydrofuran Polymers 0.000 claims abstract description 3
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229910052721 tungsten Inorganic materials 0.000 claims abstract description 3
- 239000010937 tungsten Substances 0.000 claims abstract description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 38
- 235000002639 sodium chloride Nutrition 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000011780 sodium chloride Substances 0.000 claims description 19
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 14
- 239000005561 Glufosinate Substances 0.000 claims description 8
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 150000002191 fatty alcohols Chemical class 0.000 claims description 5
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims description 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 4
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000005233 alkylalcohol group Chemical group 0.000 claims description 4
- 239000001099 ammonium carbonate Substances 0.000 claims description 4
- 238000011049 filling Methods 0.000 claims description 4
- 229930182470 glycoside Natural products 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 4
- 235000011152 sodium sulphate Nutrition 0.000 claims description 4
- 229940087291 tridecyl alcohol Drugs 0.000 claims description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 3
- 150000001412 amines Chemical class 0.000 claims description 3
- 239000012752 auxiliary agent Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 239000003760 tallow Substances 0.000 claims description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 150000008051 alkyl sulfates Chemical class 0.000 claims description 2
- 235000012538 ammonium bicarbonate Nutrition 0.000 claims description 2
- 235000012501 ammonium carbonate Nutrition 0.000 claims description 2
- 235000019270 ammonium chloride Nutrition 0.000 claims description 2
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical group [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 claims description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 2
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- 235000013877 carbamide Nutrition 0.000 claims description 2
- JZKFHQMONDVVNF-UHFFFAOYSA-N dodecyl sulfate;tris(2-hydroxyethyl)azanium Chemical compound OCCN(CCO)CCO.CCCCCCCCCCCCOS(O)(=O)=O JZKFHQMONDVVNF-UHFFFAOYSA-N 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 235000001727 glucose Nutrition 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 claims description 2
- 238000006116 polymerization reaction Methods 0.000 claims description 2
- 239000011736 potassium bicarbonate Substances 0.000 claims description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- 235000011181 potassium carbonates Nutrition 0.000 claims description 2
- 239000001103 potassium chloride Substances 0.000 claims description 2
- 235000011164 potassium chloride Nutrition 0.000 claims description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims description 2
- 229910052939 potassium sulfate Inorganic materials 0.000 claims description 2
- 235000011151 potassium sulphates Nutrition 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 235000017550 sodium carbonate Nutrition 0.000 claims description 2
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 2
- 239000001488 sodium phosphate Substances 0.000 claims description 2
- 229940048086 sodium pyrophosphate Drugs 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims description 2
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 2
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- 229910000406 trisodium phosphate Inorganic materials 0.000 claims description 2
- 235000019801 trisodium phosphate Nutrition 0.000 claims description 2
- 229910021653 sulphate ion Inorganic materials 0.000 claims 2
- BJOYVZZDDFVLPI-UHFFFAOYSA-N azanium;tetradecanoate Chemical compound [NH4+].CCCCCCCCCCCCCC([O-])=O BJOYVZZDDFVLPI-UHFFFAOYSA-N 0.000 claims 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 1
- 229940045845 sodium myristate Drugs 0.000 claims 1
- 229940102541 sodium trideceth sulfate Drugs 0.000 claims 1
- KLYDBHUQNXKACI-UHFFFAOYSA-M sodium;2-[2-(2-tridecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O KLYDBHUQNXKACI-UHFFFAOYSA-M 0.000 claims 1
- 238000001125 extrusion Methods 0.000 abstract description 9
- 238000005469 granulation Methods 0.000 abstract description 8
- 230000003179 granulation Effects 0.000 abstract description 8
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 239000000575 pesticide Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 31
- 241000196324 Embryophyta Species 0.000 description 12
- 238000000465 moulding Methods 0.000 description 11
- 238000002156 mixing Methods 0.000 description 10
- 238000001035 drying Methods 0.000 description 9
- 150000003863 ammonium salts Chemical class 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 230000004060 metabolic process Effects 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229940095686 granule product Drugs 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000009333 weeding Methods 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 150000002009 diols Chemical class 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- HMUNWXXNJPVALC-UHFFFAOYSA-N 1-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)C(CN1CC2=C(CC1)NN=N2)=O HMUNWXXNJPVALC-UHFFFAOYSA-N 0.000 description 1
- LDXJRKWFNNFDSA-UHFFFAOYSA-N 2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]ethanone Chemical compound C1CN(CC2=NNN=C21)CC(=O)N3CCN(CC3)C4=CN=C(N=C4)NCC5=CC(=CC=C5)OC(F)(F)F LDXJRKWFNNFDSA-UHFFFAOYSA-N 0.000 description 1
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 1
- 235000009328 Amaranthus caudatus Nutrition 0.000 description 1
- 240000001592 Amaranthus caudatus Species 0.000 description 1
- 239000005562 Glyphosate Substances 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 235000012735 amaranth Nutrition 0.000 description 1
- 239000004178 amaranth Substances 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000003763 chloroplast Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000010812 external standard method Methods 0.000 description 1
- 102000005396 glutamine synthetase Human genes 0.000 description 1
- 108020002326 glutamine synthetase Proteins 0.000 description 1
- XDDAORKBJWWYJS-UHFFFAOYSA-N glyphosate Chemical compound OC(=O)CNCP(O)(O)=O XDDAORKBJWWYJS-UHFFFAOYSA-N 0.000 description 1
- 229940097068 glyphosate Drugs 0.000 description 1
- 230000002363 herbicidal effect Effects 0.000 description 1
- 239000004009 herbicide Substances 0.000 description 1
- 229960004881 homosalate Drugs 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 229940037627 magnesium lauryl sulfate Drugs 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 239000002373 plant growth inhibitor Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 229940083575 sodium dodecyl sulfate Drugs 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
- A01N57/20—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds containing acyclic or cycloaliphatic radicals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P13/00—Herbicides; Algicides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- General Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Toxicology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the field of pesticides, and in particular relates to a soluble granule of glufosinate-ammonium, which comprises 50-80% of glufosinate-ammonium or salt derivatives thereof (calculated by acid), 1-20% of surfactant, 0.1-3% of forming agent, 0.1-10% of antifriction agent, 0-5% of pH regulator, 0-3% of defoaming agent and 0-40% of filler according to mass percentage; the forming agent is selected from polyoxypropylene glycol, polytetrahydrofuran glycol or polyvinyl alcohol; the anti-friction agent is selected from isomerism tridecanol random polyether, coconut oil fatty acid diethanolamide, myristoylaminopropyl dimethyl tertiary amine, palmitoylaminopropyl dimethyl tertiary amine, chitosan, nano zinc oxide or nano tungsten. The invention provides soluble granules which are convenient to prepare by extrusion granulation and have higher content of glufosinate-ammonium. The active ingredient content of the glufosinate-ammonium soluble granule is high, the dosage can be reduced, and the granule is more environment-friendly.
Description
Technical Field
The invention belongs to the field of pesticides, and in particular relates to a glufosinate-ammonium soluble granule and a preparation method thereof.
Background
The glufosinate-ammonium is also called L-type glufosinate-ammonium, and is a non-selective contact-killing type organophosphorus herbicide with low toxicity, high efficiency and partial systemic effect. After acting on plants, the plant growth inhibitor can inhibit the generation of glutamine synthetase, cause metabolic disorder and accumulation of excessive ammonia, poison the plants, and simultaneously seriously inhibit photosynthesis and disintegrate chloroplasts, thereby finally achieving the purpose of weeding. Due to the special action mechanism, the weeding speed of the glufosinate-ammonium is faster, the progress of weeds for generating resistance is slow, and the glufosinate-ammonium can act on perennial malignant weeds which cannot be killed by the glyphosate.
The temperature at which plants start to grow is about 10 ℃, and most plants stop growing when the temperature is lower than 10 ℃, so that the plants have almost no metabolic capacity; under the condition of 20-30 ℃, the metabolism ability of the plants is strongest; above 30deg.C, the metabolism of plants is reduced. The glufosinate-ammonium is weeding through the amaranth, and the metabolism capability of weeds directly influences the accumulation speed of ammonium ions, so that when the external temperature is lower than 10 ℃ or higher than 30 ℃, the metabolism of plants is stopped or slowed down, the accumulation speed of ammonium ions in the plants is slowed down, and the quick-acting property and the sterilization property of the glufosinate-ammonium are influenced. A large amount of research data prove that the temperature has an influence on the prevention effect of the glufosinate-ammonium, and the low-temperature prevention effect of the homosalate is also poor.
The existing glufosinate-ammonium product has a plurality of different dosage forms, and common dosage forms comprise soluble granules and liquid preparations. The soluble granule is a water-based environment-friendly dosage form, and can further save packaging cost and transportation cost compared with a liquid preparation, especially the soluble granule with high content. However, the glufosinate-ammonium powder has rough surface and large particle size, the particles are difficult to form and particle out in the process of preparing the solid preparation, abnormal conditions such as extrusion slip, no particle out, heating of a rotary granulator and the like are easily caused, and the granulating difficulty is increased when the content of the glufosinate-ammonium is higher.
Therefore, development of soluble granules which can stably and synergistically increase the effect under a low-temperature environment, are convenient to process and have high content of glufosinate-ammonium is needed.
Disclosure of Invention
Aiming at the defects, the invention provides soluble granules which are convenient to prepare by extrusion granulation and have higher content of the glufosinate-ammonium. The active ingredient content of the glufosinate-ammonium soluble granule is high, the dosage can be reduced, and the granule is more environment-friendly. In addition, as the content of the active ingredients of the glufosinate-ammonium soluble granules is higher, the volume is small, the long-distance transportation is facilitated, and the market demand is considerable.
In order to solve the technical problems and achieve the beneficial effects, the invention adopts the following basic conception of the technical scheme:
the glufosinate-ammonium soluble granule comprises the following components in percentage by mass:
arginate-ammonium phosphonate or its salt derivatives: 50% -80% (acid meter)
And (2) a surfactant: 1 to 20 percent of
And (3) a forming agent: 0.1 to 3 percent
Anti-friction agent: 0.1 to 10 percent
pH regulator: 0% -5%
Defoaming agent: 0% -3%
And (3) filling: 0 to 40 percent of
The forming agent is selected from polyoxypropylene glycol, polytetrahydrofuran glycol or polyvinyl alcohol;
the anti-friction agent is selected from isomerism tridecanol random polyether, coconut oil fatty acid diethanolamide, myristoylaminopropyl dimethyl tertiary amine, palmitoylaminopropyl dimethyl tertiary amine, chitosan, nano zinc oxide or nano tungsten.
As one scheme, the salt derivative of the glufosinate is selected from one or a combination of a plurality of glufosinate ammonium salt, glufosinate isopropyl salt, glufosinate potassium salt, glufosinate sodium salt, glufosinate dimethyl ammonium salt and glufosinate trimethyl sulphur salt.
As an alternative, the surfactant is selected from the group consisting of alkyl glycoside adjuvants, tallow amine polyether adjuvants, alkyl sulphates, alkyl polyether sulphates or alkyl alcohol polyethers.
As one scheme, the alkyl glycoside auxiliary agent has a solid content of more than 70%, a carbon chain length of C8-C14, a polymerization degree of 1.1-1.6 and a free fatty alcohol of less than 0.5%.
As a scheme, the content of the beef tallow amine polyether auxiliary agent is more than or equal to 99%, the carbon chain length is C12-C18, and the polyether EO number is 8-15.
Alternatively, the alkyl sulfate is selected from ammonium dodecyl sulfate, sodium dodecyl sulfate, magnesium lauryl sulfate, sodium cocoyl sulfate, and triethanolamine dodecyl sulfate.
Alternatively, the alkyl polyether sulfate is selected from the group consisting of sodium dodecyl polyether sulfate, ammonium dodecyl polyether sulfate, sodium cocoyl polyether sulfate, triethanolamine dodecyl polyether sulfate, ammonium myristyl polyether sulfate, sodium myristyl polyether sulfate, and sodium tridecyl polyether sulfate.
Alternatively, the alkyl alcohol polyether is selected from the group consisting of linear aliphatic alcohol polyethers and isomeric tridecyl alcohol polyethers.
As one scheme, the filler is selected from one or more of ammonium sulfate, potassium sulfate, sodium sulfate, ammonium chloride, potassium chloride, sodium chloride, ammonium bicarbonate, potassium bicarbonate, sodium bicarbonate, ammonium carbonate, potassium carbonate, sodium carbonate, soluble starch, lactose, glucose, sodium pyrophosphate, trisodium phosphate and urea.
The invention also provides a preparation method of the glufosinate-ammonium soluble granule, which is characterized in that all components of the glufosinate-ammonium soluble granule are directly extruded and granulated without water.
Compared with the prior art, the invention has the following advantages:
1. the refined glufosinate-ammonium soluble granule prepared by the invention has full appearance, is easy to disintegrate, meets various indexes of products, has simple and convenient whole granulation and drying process and low energy consumption.
2. The glufosinate-ammonium soluble granule disclosed by the invention is prepared by directly mixing all materials uniformly and then extruding and granulating without adding water as an adhesive in the extrusion and granulating process, so that the entry of extra moisture into the granule is reduced, and the water content is reduced.
3. The glufosinate-ammonium soluble granule disclosed by the invention is matched with the forming agent through the antifriction agent, so that the concave parts on the surfaces of the granules are filled with filling-up or a structure similar to a smooth film is formed, the roughness of the surfaces of the granules is reduced, and the appearance of the granules is smooth and full; the forming and discharging are easier, the granulating process is smoother, the granulating forming is fuller, and the production efficiency and the quality of the granules are improved.
4. The friction degree between the granules of the soluble granule of the glufosinate-ammonium and equipment is small, so that the heating of materials caused by overlarge friction is avoided, the loss of ammonium salt active ingredients is avoided, and the better quality is ensured.
5. The soluble granule of the glufosinate-ammonium can be dried below 70 ℃, and on the premise of ensuring that the water content in the product is qualified, the product cations in salts such as the glufosinate-ammonium salt, the glufosinate-isopropyl amine and the glufosinate-dimethylamine are ensured not to be unqualified due to high-temperature escape.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more clear, the technical solutions of the embodiments of the present invention are clearly and completely described below. It will be apparent that the described embodiments are some, but not all, embodiments of the invention. All other embodiments, which can be made by a person skilled in the art without creative efforts, based on the described embodiments of the present invention fall within the protection scope of the present invention.
The 86.8% raw powder of the glufosinate-ammonium salt used in the following cases means that the content of the glufosinate-ammonium in the raw powder is 86.8%.
The content limits of soluble granules prepared in each case are marked by the content of arginate.
EXAMPLE 1 50% soluble granules of arginate ammonium salt (acid meter)
The raw materials comprise the following components:
arginate-ammonium phosphonate or its salt derivatives: 57.7g of 86.8 percent of refined ammonium glufosinate ammonium salt raw powder (acid meter)
And (2) a surfactant: 10g of direct-linked fatty alcohol polyether sodium sulfate
And (3) a forming agent: polyoxypropylene diol 2g
Anti-friction agent: coconut oil fatty acid diethanolamide 2g
And (3) filling: 28.3g of sodium chloride.
Accurately weighing the components according to the proportion, mixing uniformly, and directly granulating in an extrusion granulator without adding water.
And after the granulation is finished, drying for 1h at 70 ℃, then drying for 1h at 100 ℃, and taking out.
EXAMPLE 2 70% soluble granules of arginate ammonium salt (acid meter)
The raw materials comprise the following components:
arginate-ammonium phosphonate or its salt derivatives: 80.7g of 86.8 percent of refined ammonium glufosinate ammonium salt raw powder (acid meter)
And (2) a surfactant: 10g of direct-linked fatty alcohol polyether sodium sulfate
And (3) a forming agent: polyoxypropylene diol 2g
Anti-friction agent: coconut oil fatty acid diethanolamide 2g
pH regulator: 0.2g
Defoaming agent: 0.2g
And (3) filling: sodium chloride 4.9g.
Accurately weighing the components according to the proportion, mixing uniformly, and directly granulating in an extrusion granulator without adding water.
And after the granulation is finished, drying for 1h at 70 ℃, then drying for 1h at 100 ℃, and taking out.
Example 3 80% soluble granules of arginate ammonium salt (calculated as acid)
The raw materials comprise the following components:
arginate-ammonium phosphonate or its salt derivatives: 92.2g of 86.8 percent of refined ammonium glufosinate ammonium salt raw powder (acid meter)
And (2) a surfactant: 5.8g of sodium direct fatty alcohol polyether sulfate
And (3) a forming agent: polyvinyl alcohol 1g
Anti-friction agent: nano zinc oxide 1g
Accurately weighing the components according to the proportion, mixing uniformly, and directly granulating in an extrusion granulator without adding water.
And after the granulation is finished, drying for 1h at 70 ℃, then drying for 1h at 100 ℃, and taking out.
Comparative examples 1 to 1
The comparative example differs from example 1 in that the sodium chloride is used in an amount of 30.4g without the addition of a shaping agent.
Comparative examples 1 to 2
The comparative example differs from example 1 in that 30.4g of sodium chloride was used, no molding agent was added, and 8g of water was added during the mixing.
Comparative examples 1 to 3
This comparative example differs from example 1 in that 30.4g of sodium chloride was used without adding an anti-friction agent.
Comparative examples 1 to 4
This comparative example differs from example 1 in that the sodium chloride was used in an amount of 32.4g without the addition of a molding agent and an anti-friction agent.
Comparative examples 1 to 5
This comparative example differs from example 1 in that the sodium chloride was used in an amount of 32.4g, no molding agent and no anti-friction agent were added, and 8g of water was added during the mixing.
Comparative example 2-1
The comparative example differs from example 2 in that sodium chloride was used in an amount of 7g without the addition of a molding agent.
Comparative examples 2 to 2
The comparative example differs from example 2 in that the sodium chloride was used in an amount of 7g, no molding agent was added, and 8g of water was added during the mixing.
Comparative examples 2 to 3
This comparative example differs from example 2 in that sodium chloride was used in an amount of 7g without adding an anti-friction agent.
Comparative examples 2 to 4
The comparative example differs from example 2 in that 9g of sodium chloride was used without the addition of a molding agent and an anti-friction agent.
Comparative examples 2 to 5
This comparative example differs from example 2 in that sodium chloride was used in an amount of 9g, no molding agent and no anti-friction agent were added, and 8g of water was added during the mixing.
Comparative example 3-1
The comparative example differs from example 3 in that sodium chloride was used in an amount of 1g without the addition of a molding agent.
Comparative example 3-2
The comparative example differs from example 3 in that 1g of sodium chloride was used, no molding agent was added, and 8g of water was added during the mixing.
Comparative examples 3 to 3
This comparative example differs from example 3 in that sodium chloride was used in an amount of 1g without adding an anti-friction agent.
Comparative examples 3 to 4
This comparative example differs from example 3 in that sodium chloride was used in an amount of 2g without the addition of a molding agent and an anti-friction agent.
Comparative examples 3 to 5
The comparative example differs from example 3 in that the sodium chloride was used in an amount of 2g, no molding agent and no anti-friction agent were added, and 8g of water was added during the mixing.
Performance testing
The granules of each example and each comparative example were compared in combination.
(1) Extrusion granulation condition comparison: visual inspection was made as to whether the granulator was able to continuously and smoothly extrude granules, and whether the appearance shape of the discharged granules was full.
(2) And (3) comparing product indexes: the water content measuring method is carried out according to the national standard GB/T1600-2021; the ammonium radical determination method comprises the following steps: the sample is dissolved by deionized water, aqueous solution of methylsulfonic acid is taken as a mobile phase, and the cation analysis chromatographic column and an ion chromatograph with a conductivity detector are used for separating and measuring ammonium ions in the sample, so that the ammonium ions are quantified by an external standard method. See enterprise standard Q/XHG 2113-2022 for details. The comparison is specifically as follows:
TABLE 1 comparison of 50% soluble granule product of arginate ammonium salt
Table 2 comparison of 70% soluble granule product of arginate ammonium salt
Table 3 comparison of 80% soluble granule product of arginate ammonium salt
From the data in the above table, it can be found that the soluble granules of the smart glufosinate-ammonium in the embodiments 1-3 are plump in appearance and good in formability; the product has low water content (less than 3%), and higher ammonium content, namely, the escape amount of ammonium in the extrusion granulation and drying processes is very small under the conditions of reducing powder friction, removing water for kneading and drying at low temperature, and the water content in the system is limited.
Claims (10)
1. The glufosinate-ammonium soluble granule comprises the following components in percentage by mass:
arginate-ammonium phosphonate or its salt derivatives: 50 to 80 percent of acid
And (2) a surfactant: 1 to 20 percent of
And (3) a forming agent: 0.1 to 3 percent
Anti-friction agent: 0.1 to 10 percent
pH regulator: 0% -5%
Defoaming agent: 0% -3%
And (3) filling: 0 to 40 percent of
The forming agent is selected from polyoxypropylene glycol, polytetrahydrofuran glycol or polyvinyl alcohol;
the anti-friction agent is selected from isomerism tridecanol random polyether, coconut oil fatty acid diethanolamide, myristoylaminopropyl dimethyl tertiary amine, palmitoylaminopropyl dimethyl tertiary amine, chitosan, nano zinc oxide or nano tungsten.
2. The soluble granule of glufosinate-ammonium according to claim 1, wherein the salt derivative of glufosinate-ammonium is selected from one or a combination of several of glufosinate-ammonium salt, glufosinate-isopropyl salt, glufosinate-potassium salt, glufosinate-sodium salt, glufosinate-dimethyl salt, and glufosinate-trimethyl-sulfur salt.
3. The smart glufosinate-soluble granule of claim 1, wherein the surfactant is selected from alkyl glycoside aids, tallow amine polyether aids, alkyl sulfates, alkyl polyether sulfates, or alkyl alcohol polyethers.
4. The soluble granule of arginate-ammonium according to claim 3, wherein the alkyl glycoside auxiliary agent has a solid content of > 70%, a carbon chain length of C8-C14, a degree of polymerization of 1.1-1.6, and a free fatty alcohol of < 0.5%.
5. The soluble granule of smart glufosinate-ammonium according to claim 3, wherein the content of the said amine-ester polyether adjuvant is more than or equal to 99%, the carbon chain length is C12-C18, and the polyether EO number is 8-15.
6. A soluble granule of arginate according to claim 3, wherein the alkyl sulphate is selected from ammonium dodecyl sulphate, sodium dodecyl sulphate, magnesium lauryl sulphate, sodium cocoyl sulphate or triethanolamine dodecyl sulphate.
7. A soluble granule of arginate according to claim 3, wherein the alkyl polyether sulfate is selected from sodium dodecyl polyether sulfate, ammonium dodecyl polyether sulfate, sodium coco polyether sulfate, triethanolamine dodecyl polyether sulfate, ammonium myristate polyether sulfate, sodium myristate polyether sulfate or sodium trideceth sulfate.
8. A smart glufosinate-soluble granule according to claim 3 wherein the alkyl alcohol polyether is selected from linear aliphatic alcohol polyethers or isomeric tridecyl alcohol polyethers.
9. The soluble granule of arginate-ammonium according to claim 1, wherein the filler is selected from one or more of ammonium sulfate, potassium sulfate, sodium sulfate, ammonium chloride, potassium chloride, sodium chloride, ammonium bicarbonate, potassium bicarbonate, sodium bicarbonate, ammonium carbonate, potassium carbonate, sodium carbonate, soluble starch, lactose, glucose, sodium pyrophosphate, trisodium phosphate, urea.
10. The method for preparing the soluble granule of smart glufosinate according to any one of claims 1-9, wherein the components of the soluble granule of smart glufosinate are directly extruded and granulated without water.
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