CN117530974A

CN117530974A - Traditional Chinese medicine for treating intestinal constipation

Info

Publication number: CN117530974A
Application number: CN202311504708.6A
Authority: CN
Inventors: 巩跃生; 董雷; 杨峰; 王雪; 刘超峰; 张雅儒; 张威; 黄梅; 曹琼月; 张席; 李永伟
Original assignee: Zhengzhou Large Intestine And Anus Disease Hospital
Current assignee: Zhengzhou Large Intestine And Anus Disease Hospital
Priority date: 2023-11-13
Filing date: 2023-11-13
Publication date: 2024-02-09

Abstract

A traditional Chinese medicine for treating intestinal constipation is prepared from the following raw materials in parts by weight: 55-65g of fructus trichosanthis, 5-7g of angelica, 8-12g of astragalus, 8-12g of raw bighead atractylodes rhizome, 5-7g of polygonum multiflorum, 8-12g of bitter apricot seed, 5-7g of safflower, 5-7g of fried bitter orange and 5-7g of liquorice; mixing the above components, soaking in water, decocting for 1.1 h times the total weight of the raw materials, decocting for 0.5 hr, mixing decoctions, and filtering. The invention has the advantages of rich raw materials, low cost, good effect, simple preparation method, easy production and preparation, and has the effects of relaxing bowel and effectively improving intestinal constipation, stable and reliable curative effect, no toxic or side effect and remarkable social and economic benefits.

Description

Traditional Chinese medicine for treating intestinal constipation

Technical Field

The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for treating intestinal constipation.

Background

Constipation refers to a clinical symptom(s) that is manifested by difficulty in defecation and/or reduced number of times of defecation, and dry and hard stool. The difficult defecation comprises difficult defecation, anorectal blockage, incomplete defecation, time-consuming defecation and the need of manual assistance. The reduced number of bowel movements means that bowel movements are <3 times per week. The course of chronic constipation should be more than or equal to 6 months.

At present, a lot of medicines for treating constipation are available, but the common laxatives still take stimulative laxatives as main medicines, the traditional Chinese medicine laxatives often take anthraquinone laxatives such as rheum officinale, senna leaves and the like as main medicines, and western medicine laxatives take diphenols as preparations for multiple purposes. Some health foods also have the effect of relieving habitual constipation, but have higher lazy property and are not suitable for treating constipation. In the prior art, medicines for treating constipation are various, but have weak pertinence and insignificant treatment effect, so that the medicine which is safe and has no toxic or side effect and is suitable for constipation is continuously researched, but related public reports are not found up to the present.

Disclosure of Invention

Aiming at the situation, the invention aims to overcome the defects of the prior art and provide the traditional Chinese medicine for treating the intestinal constipation, which can effectively solve the problem of poor effect of the traditional medicine for treating the intestinal constipation.

In order to achieve the aim, the technical scheme of the invention is that the traditional Chinese medicine for treating intestinal constipation is prepared from the following raw materials in parts by weight: 55-65g of fructus trichosanthis, 5-7g of angelica, 8-12g of astragalus, 8-12g of raw bighead atractylodes rhizome, 5-7g of polygonum multiflorum, 8-12g of bitter apricot seed, 5-7g of safflower, 5-7g of fried bitter orange and 5-7g of liquorice; mixing the above components, soaking in water, decocting for two times, adding water with a volume which is 8 times of the total weight of the raw materials for decocting for 1 h to obtain a first decoction, adding water with a volume which is 6 times of the total weight of the raw materials for decocting for 0.5h to obtain a second decoction, mixing the two decoctions, and filtering to obtain the final product; the weight volume is solids in g and liquids in ml.

The invention has the advantages of rich raw materials, low cost, good effect, simple preparation method, easy production and preparation, and has the effects of relaxing bowel and effectively improving intestinal constipation, stable and reliable curative effect, no toxic or side effect and remarkable social and economic benefits.

Drawings

FIG. 1 is a graph (40X 10) showing the results of HE staining according to the invention.

Detailed Description

The following describes in detail the embodiments of the present invention with reference to the drawings and examples.

The invention, when embodied, is illustrated by the following examples.

Example 1

A traditional Chinese medicine for treating intestinal constipation is prepared from the following raw materials in parts by weight: 55g of snakegourd fruit, 5g of Chinese angelica, 8g of astragalus, 8g of raw bighead atractylodes rhizome, 5g of polygonum multiflorum, 8g of bitter apricot seed, 5g of safflower, 5g of fried bitter orange and 5g of liquorice; mixing the above components, soaking in water, decocting for 1.1 h times the total weight of the raw materials, decocting for 0.5 hr, mixing decoctions, and filtering.

Example 2

A traditional Chinese medicine for treating intestinal constipation is prepared from the following raw materials in parts by weight: 60g of snakegourd fruit, 6g of Chinese angelica, 10g of astragalus, 10g of raw bighead atractylodes rhizome, 6g of polygonum multiflorum, 10g of bitter apricot seed, 6g of safflower, 6g of fried bitter orange and 6g of liquorice, and the preparation method is the same as that of the example 1.

Example 3

A traditional Chinese medicine for treating intestinal constipation is prepared from the following raw materials in parts by weight: 65g of snakegourd fruit, 7g of Chinese angelica, 12g of astragalus, 12g of raw bighead atractylodes rhizome, 7g of polygonum multiflorum, 12g of bitter apricot seed, 7g of safflower, 7g of fried bitter orange and 7g of liquorice, and the preparation method is the same as that of the example 1.

Example 4

A traditional Chinese medicine for treating intestinal constipation is prepared from the following raw materials in parts by weight: 58g of snakegourd fruit, 7g of Chinese angelica, 11g of astragalus, 9g of raw bighead atractylodes rhizome, 5g of polygonum multiflorum, 9g of bitter apricot seed, 6g of safflower, 7g of fried bitter orange and 5g of liquorice, and the preparation method is the same as that of the example 1.

Example 5

A traditional Chinese medicine for treating intestinal constipation is prepared from the following raw materials in parts by weight: 62g of snakegourd fruit, 5g of Chinese angelica, 9g of astragalus, 11g of raw bighead atractylodes rhizome, 6g of polygonum multiflorum, 11g of bitter apricot seed, 5g of safflower, 6g of fried bitter orange and 7g of liquorice, and the preparation method is the same as that of the example 1.

In the above-mentioned medicine, the medicine,

all snakegourd fruit: sweet in flavor, slightly bitter in flavor, cold in nature, enters liver, stomach and large intestine meridians. Belongs to the dry tuber of the cucurbitaceae plant anemone. Has effects of clearing heat, eliminating phlegm, relieving chest stuffiness, resolving hard mass, loosening bowel to relieve constipation, etc. Fructus Trichosanthis can be used for treating cough due to phlegm heat, phlegm nodule, thoracic obstruction, acute appendicitis, acute mastitis, constipation due to intestinal dryness, etc.

Chinese angelica root: sweet and pungent in flavor, warm in nature, and enters liver, heart and spleen meridians. Sweet and moist, pungent and warm in nature, it enters liver and heart meridians and spleen meridians. It is good at replenishing blood and activating blood, regulating menstruation and relieving pain, relaxing bowel and expelling cold, and is suitable for treating constipation due to blood deficiency and blood stasis, especially constipation due to dryness of the intestines, and is not only a key herb for regulating menstruation in gynecology but also a good blood-replenishing product in internal medicine and is commonly used for detumescence and wound therapy in surgery.

Radix astragali: sweet and slightly warm nature, enter spleen and lung meridians. Is dry root of Astragalus mongholicus bge or Astragalus membranaceus bge. Gan Wenbu L, sweet and bland, and good permeability; it is used with mild condition and stir-baked with honey to warm the spleen and lung meridians, strengthen body resistance and remove pathogenic factors. It is good at tonifying middle-jiao qi, promoting the production of qi and clearing yang, tonifying lung qi, invigorating stomach and consolidating exterior, and can be used for treating spleen-lung qi deficiency, sinking of middle-jiao qi, qi failing to control blood, spontaneous perspiration and night sweat, etc., and also for treating sore, carbuncle, non-ulcer or chronic ulcer due to qi and blood deficiency, qi deficiency and edema, dysuria.

Raw white atractylodes rhizome: bai Zhu is bitter, sweet and warm in nature. Enter spleen and stomach meridians. The raw Atractylodis rhizoma is dry rhizome of Atractylodis rhizoma of Compositae. Can strengthen the spleen and replenish qi, and is a good medicine for invigorating qi and strengthening the spleen. Can be used for treating abdominal distention and diarrhea due to spleen qi deficiency and spleen and stomach deficiency cold. Stagnation in the stomach and distention and fullness due to spleen deficiency. Raw Bai Zhu also can dry dampness and promote diuresis and is used for treating phlegm and water swelling and the like. Can be used for treating spontaneous perspiration due to qi deficiency, and preventing miscarriage.

Polygonum multiflorum Thunb: bitter, sweet and astringent in taste and slightly warm. It enters liver, heart and kidney meridians. The deficiency tonifying medicine is dried root tuber of Polygonum multiflorum Thunb of Polygonaceae. It enters liver and kidney meridians and has different actions of making and growing. It is slightly warm in preparation, sweet and astringent in flavor, not greasy and not dry, good in tonifying liver and kidney, replenishing essence and blood, and blackening hair and beard, and is a tonic good herb for deficiency of essence and blood. It has the effects of relieving sore, swelling, scrofula, and constipation due to weakness, promoting the circulation of qi, and tonifying deficiency.

Bitter apricot kernel: bitter and slightly warm; it is slightly toxic. Enter lung and large intestine meridians. Bitter and purgation, rich in fat, slight in temperature and small in toxicity, strong in medicinal efficacy, and enters the lung and large intestine meridians. It can lower lung qi to relieve cough and dyspnea, moisten intestine and dry stool, and also has the actions of ventilating lung to treat various cough and dyspnea and constipation due to intestine dryness.

Safflower: pungent and warm in flavor. It enters heart and liver meridians. Is dried flower of Carthami flos of Compositae. Pungent and dispersed warm are introduced into the heart and liver meridians. It is good at activating blood and resolving stasis, inducing menstruation and relieving swelling and pain, and is indicated for all syndromes of blood stasis with strong medicinal herbs.

Stir-frying fructus aurantii: has pungent and bitter taste, can promote qi circulation and reduce qi, can relieve cough symptoms caused by qi stagnation between chest and abdomen, is a common medicine for clinically treating chest distress and qi stagnation, and has relieving effect on uncomfortable symptoms such as intestinal wind, blood stasis, rubella pruritus, gestational abdominal pain and the like. Has effects in removing food stagnation, relieving stagnation, promoting qi downward, relieving distention, resolving food stagnation, relieving dyspepsia, abdominal pain, abdominal distention, anorexia, etc., and can be used for treating edema, constipation, uterus prolapse, rectocele, etc.

Licorice root: sweet and flat nature, it enters heart, lung, spleen and stomach meridians. Is dry root and rhizome of Glycyrrhiza uralensis Fisch, glycyrrhiza uralensis Fisch or Glycyrrhiza glabra of Leguminosae. Sweet and smooth, and mild, it is effective in promoting the production of flat and cool, and it is effective in treating flat and warm, and it is indicated for spleen and lung meridians, stomach and heart meridians. Not only tonify qi and strengthen middle energizer, but also relieve spasm and pain, alleviate drug properties, and also eliminate phlegm and relieve cough and detoxify. The honey-fried qi-tonifying and urgent-relieving effects are strong; it can purge fire and detoxify.

The invention takes the whole snakegourd fruit and the bitter apricot seed as principal drugs for relaxing bowels, takes safflower as ministerial drugs for dispersing the heat and dredging, astragalus root as sweet and warm tonifying, raw atractylodes macrocephala as qi-tonifying and spleen-strengthening, and takes the fried bitter orange as ministerial drugs for promoting digestion and resolving food stagnation, can relieve dyspepsia, abdominal pain and abdominal distention, inappetence and the like caused by dyspepsia, takes the polygonum multiflorum as good tonic drugs for treating deficiency of essence and blood, takes the angelica and the liquorice as adjuvant drugs, takes the angelica and the liquorice as sweet and moisturizing and tempering drugs, and takes the medicines as messenger drugs. The medicines monarch, minister, assistant and guide are scientifically and reasonably combined, mutually support each other, mutually cooperate, exert the curative effect of the medicines and reduce the side effect on the body.

The traditional Chinese medicine composition disclosed by the invention is prepared scientifically according to the monarch, minister, assistant, guide, strict in compatibility, complementary, stable in quality, good in curative effect, and quite good in beneficial technical effect through experiments, and related experimental data are as follows (taking example 2):

1. animal experiment

1. Materials and methods

1.1 laboratory animals, medicaments and reagents

Experimental animals: male SPF-grade Kunming mice, 60, weighing (20+ -2) g, 6-8 weeks old, were purchased from Si Bei Fu (Beijing) Biotechnology Co. And (3) adaptively feeding for 7 days, and controlling the relative humidity to be 50+/-10% and the temperature to be 23+/-2 ℃ by free diet and drinking water.

1.2 animal model preparation

The constipation model group, the recovery control group and the drug treatment group were given loperamide solution 20mg/kg for 1 time/d for 1 week. The blank group was given an equivalent dose of normal saline for lavage.

1.3 Experimental grouping and administration

The 60 mice were randomly divided into 4 groups of 10 mice each, which were blank group, constipation model group, recovery control group, and drug treatment group. The medicine treatment group was given 0.3ml/10g of the traditional Chinese medicine (snakegourd intestine-moistening soup) prepared in the example 2 for lavage, the control group was recovered to be given 2.5mg/kg of mosapride for lavage, and the blank group and the constipation model group were given equal doses of physiological saline for lavage. Each group was irrigated 1 time/d, followed by 7d.

1.4 fecal moisture content

The fecal water content of the mice after the last drug administration was recorded. Collecting 24-h stool of each group of mice, weighing the wet weight of the stool of the mice, drying by an electrothermal constant-temperature blast drier, immediately taking out the dried weight after reaching the drying standard, measuring the dry weight, calculating the water content, and judging the influence of the snakegourd intestine-moistening soup on constipation of experimental animals.

1.5 intestinal Propulsion

The measurement is carried out by adopting a magenta solution method, after blood is taken from the eyeball, the pylorus is taken out from the cecum immediately after the laparotomy, and the total length of the intestinal canal and the pushing length of the magenta in the intestinal canal are measured under the condition of no tension.

The calculation formula is as follows: small intestine propulsion = (pylorus to red intestine infected distance/pylorus to cecum full length) ×100%.

1.6 hematoxylin-eosin (HE) staining for the observation of colon tissue pathology

Fresh colon tissue of a mouse is taken and fixed by 4% paraformaldehyde fixing solution, and the colon tissue pathological changes are photographed by a microscope through conventional dehydration, wax dipping, embedding, slicing, unfolding, baking and HE staining.

1.7 determination of serum VIP, 5-HT, SS and SP levels

After blood is taken from eyeballs, the eyeballs are centrifuged for 15min at 3500r/min, serum is taken, the levels of VIP, 5-HT, SS and SP in the serum are determined by adopting an ELISA method, and all operations are strictly determined according to the instruction book of the kit.

1.8 statistical methods

Data analysis data processing was performed using SPSS 25.0 software. Experimental data are expressed by mean value +/-standard deviation, single-factor variance analysis is adopted, turkey HSD and LSD methods are selected for analysis and comparison when multiple comparison variances are uniform, tamhane's T test and Dunnet are selected when variances are irregularthe t's T method is used for analysis and comparison, and all statistical tests are performedP<The concentration of 0.05 was found to be significant,P<0.01 is very significant.

2. Results

2.1 Fecal moisture content

The water content of the feces of the mice in the constipation model group is obviously lower than that of the feces in the blank groupP<0.01 Recovery control and drug treatment groups higher than constipation model groupP<0.05，P<0.01). See table 1.

Table 1 fecal moisture content of mice in each group

Grouping	Fecal moisture content
		Blank group	0.39±0.05
Constipation model group	0.32±0.06**
		Recovery control group	0.40±0.06**
Drug treatment group	0.39±0.06**

Note that: comparison with blank groupP<0.05, **P<0.01; comparison with constipation model groupP<0.05, **P<0.01

2.2 Intestinal tract propulsion rate

The intestinal propulsion rate of the mice in the constipation model group is obviously lower than that of the mice in the blank groupP<0.01 Recovery of control and drug treatment group heightModel group of constipationP<0.01 And the drug-treated group was higher than the recovery control group. See table 2.

Table 2 intestinal tract propulsion rate of mice of each group

Grouping	Intestinal tract propulsion rate
		Blank group	0.93±0.03
Constipation model group	0.73±0.14**
		Recovery control group	0.90±0.06**
Drug treatment group	0.92±0.06**

2.3 Pathological staining of colon

The results are shown in figure 1, the colon mucosa of the blank group has no obvious congestion, edema and erosion, smooth surface and regular glands; the constipation model group can be used for treating mucosal congestion and swelling, the mucosal structure is less clear, the surface is not smooth, and glands are atrophic and disordered; the recovery control group and the drug treatment group have smoother mucous membrane surface, tidy gland arrangement, goblet cell increase and the like. .

2.4 VIP, SS, 5-HT and SP level changes in serum

The VIP and SS levels of the constipation model group are obviously higher than those of the blank groupP<0.05，P<0.01 Restoring the control group and the drug treatment group to be lower than the constipation model groupP<0.05，P<0.01 And the drug-treated group was lower than the recovery control group. Constipation model group 5-HT and SP levels were significantly lower than those of blank groupP<0.01，P<0.05 The recovery control group and the drug treatment group are obviously higher than the constipation model groupP<0.01 And the drug-treated group was higher than the recovery control group. See table 3.

TABLE 3 changes in VIP and SP levels in serum

Grouping	VIP	SS	5-HT	SP
					Blank group	137.43±9.75	13.24±0.83	177.47±18.71	20.37±6.04
Constipation model group	152.34±7.04*	16.17±1.85**	122.85±25.29**	12.96±6.07*
					Recovery control group	135.47±19.93*	11.91±1.06**	202.76±33.08**	20.56±4.93**
Drug treatment group	134.00±19.21**	13.49±1.36**	235.61±10.74**	41.12±8.88**

2. Clinical trials

On the basis of ensuring safety of animal experiments, the effect is very good through clinical trial, and taking constipation with qi constipation as an example, relevant experimental data are as follows:

1. diagnostic criteria:

1.1 Western medicine diagnostic criteria (reference Roman IV functional Constipation diagnostic criteria)

(1) The following 2 or more symptoms must be met:

(1) more than one fourth of the defecation feel hard;

(2) more than one fourth of the excrement is in a dry ball shape or a hard excrement block;

(3) more than one fourth of the defecation feel a sense of incomplete defecation;

(4) more than one-fourth of the bowel movements feel anorectal obstruction or obstruction;

(5) more than one fourth of the defecation needs to be supported by fingers or the basin bottom to assist the defecation;

(6) spontaneous defecation is less than 3 times/week;

(2) Substantially no discharge of a thin stool when no laxative is applied;

(3) Clinical symptoms do not support diagnosis of irritable bowel syndrome;

(4) And constipation caused by organic lesions, medicines and the like of the whole body of the intestinal tract is eliminated.

Clinical symptoms have appeared for 6 months or more, and nearly 3 months symptoms meet the above diagnostic criteria.

1.2 diagnostic criteria of traditional Chinese medicine (refer to the guide 2019 on the basic diagnosis and treatment of chronic constipation)

1.3 traditional Chinese medicine qi-secret diagnosis standard (refer to the guiding principle of clinical research of new traditional Chinese medicine, the common opinion of medical science of combined diagnosis and treatment of 2017 functional constipation and the combined internal science of Chinese and Western medicine)

Main symptoms are as follows: the defecation is laborious, the defecation is incomplete after defecation, or difficult and unsmooth, dry or not very dry stool, abdominal distending pain and less defecation times;

secondary symptoms: borborygmus and flatulence, anxiety depression or dysphoria and irritability, chest and hypochondrium fullness and distention, frequent eructation and anorexia;

tongue pulse: a red tongue with thin and greasy coating and a wiry pulse.

The main symptoms are indispensable, the secondary symptoms conform to 2 or more reference tongue vessels, and can be diagnosed as qi-secret syndrome.

2. Selection of case criteria

(1) Meets the diagnostic standard of Roman IV functional constipation in modern medicine;

(2) Meets the diagnosis standard of the qi and the secret of the traditional Chinese medicine;

(3) Age between 18 and 65 years old;

(4) Patient compliance was better and voluntarily participated in this study, identifying informed consent.

3. Treatment protocol:

the 64 diagnosed patients with functional constipation (qi constipation) are outpatient patients, and are randomly divided into a treatment group and a control group, wherein each group is divided into 32 persons, the treatment group takes the traditional Chinese medicine (snakegourd fruit intestine-moistening soup) prepared in the example 2 (one dose), the control group takes the four-grinding soup oral liquid, the treatment course is 2 weeks, and the curative effect is evaluated after 2 treatment courses are finished.

During the treatment period, the two groups of patients stop using other medicines for treating constipation, keep happy mood, drink 1.5-2.0L of water every day, drink light diet, avoid spicy stimulation, eat 20-30 g of dietary fiber in proper quantity, take care of rest, do not stay up night, exercise moderately, develop good defecation habit, defecation regularly every day, do not inhibit defecation, and massage abdomen every day.

4. Efficacy assessment:

4.1 efficacy index Observation

(1) Recording the main symptom integral of defecation effort, abdominal distention and pain, falling inexhaustible feeling, defecation frequency, defecation time and fecal character of two groups of patients before and after treatment;

(2) The symptoms and signs of borborygmus, vector qi, anxiety depression or dysphoria, irritability, chest and hypochondrium fullness, belch frequent pattern and anorexia before and after treatment are recorded for the two groups of patients.

4.2 criteria for symptom grading score:

the constipation Chinese medical diagnosis and treatment consensus opinion and the Chinese and Western medical consensus opinion are referred to, and are classified into 0, 1, 2 and 3 according to the severity of the disease, and the main symptoms are respectively classified into 0, 2, 4 and 6. The secondary symptoms were respectively marked as 0, 1, 2 and 3 points. Tongue pulse is not counted as a score due to individual differences.

4.3 constipation efficacy assessment criteria

Referring to the treatment effect evaluation standard of the syndrome in the constipation Chinese medical diagnosis and treatment consensus opinion:

and (3) healing: all qi secret and related symptoms and physical signs disappear or nearly disappear, and the curative effect index n is more than or equal to 95%;

the effect is shown: the qi secret and related symptoms and physical signs are obviously reduced before, and the curative effect index n is more than or equal to 70% and less than 95%;

the method is effective: the qi secret and related symptoms and signs are improved, and the curative effect index n is less than or equal to 30 percent and less than 70 percent;

invalidation: the qi secret and the related symptoms and signs are not improved, even aggravated, and the curative effect index n is less than 30%.

Note that: n= [ (pre-treatment symptom score-post-treatment symptom score)/pre-treatment symptom score ] ×100%.

5. Clinical statistics results:

the 64 diagnosed patients fall off 4 during the treatment course, and finally 60 patients are included in the statistics. 30 of the treatment groups, 13 men and 17 women, age 49.70 + -9.17 years old; 30 control groups, 11 men and 19 women; the ages 50.47 + -8.23 years. There is comparability between the two groups.

After treatment according to the treatment scheme given above, 30 treatment groups had cured 4 (13.33%), 15 (50.00%), 10 (33.33%), 1 (3.33%) and the total effective rate was 96.66%. 30 cases of the control group are cured 1 case (3.33%), 9 cases of obvious effect (30.00%), 14 cases of effective effect (46.67%), 6 cases of ineffective effect (20.00%), and the total effective rate is 80.00%. The effective rate of the treatment group is obviously higher than that of the control group, and no adverse reaction and toxic or side effect are found during the test.

After the treatment is finished for 4 weeks, all patients in the treatment group and the control group are subjected to telephone follow-up, 23 patients in the treatment group have good complaining and defecation conditions, the illness state is not repeated, 5 patients complain of illness state is lightened, the treatment is continued, and 2 patients complain of illness state relapse, and the relapse rate is 6.67%. The 17 patients in the control group have good complaint and defecation conditions, the disease condition is not repeated, the disease condition of 4 patients is relieved, the medicine is continuously taken for treatment, the disease condition of 9 patients is recurred, the recurrence rate is 30.00 percent, and the patients are subjected to chi-square test (chi-square test ² =0.278, p=0.045) suggests that the snakegourd intestine-moistening soup of the present invention is significantly better than the tetramill soup oral liquid in treating the long-term efficacy in functional constipation.

Meanwhile, the experiment is carried out on the embodiment 2, and the same experiment is carried out on other embodiments, so that the same and similar results as those of the embodiment 2 are obtained, and the results are not listed one by one, so that the invention has good effect and stable and reliable curative effect.

3. Conclusion(s)

In conclusion, the traditional Chinese medicine (snakegourd intestine-moistening soup) for treating intestinal constipation has the advantages of scientific and reasonable component compatibility, abundant raw materials, simple preparation method, low cost, good effect, stable and reliable curative effect, no toxic or side effect, high safety, low cost and the like, has the efficacy of moistening the intestines to relieve constipation and effectively improving constipation, has the advantages of 96.66 percent, has good use value, is easy to popularize and apply, and is a great innovation in medicines for improving intestinal constipation, and economic and social benefits are remarkable.

The technical characteristics and key points of the invention are that the traditional Chinese medicine composition is compatible, the decoction is only one dosage form embodiment, and all dosage forms which are made by adopting equivalent replacement means and are applicable to taking, such as powder (pulvis), granules, pills, tablets, oral liquid, capsules, extract powder and the like, are prepared by adopting the traditional Chinese medicine composition according to the technical scheme which is basically the same as the invention or adopting the traditional Chinese medicine composition to prepare the traditional Chinese medicine composition by adopting a conventional preparation method, and belong to the protection scope of the invention.

Claims

1. The traditional Chinese medicine for treating intestinal constipation is characterized by being prepared from the following raw materials in parts by weight: 55-65g of fructus trichosanthis, 5-7g of angelica, 8-12g of astragalus, 8-12g of raw bighead atractylodes rhizome, 5-7g of polygonum multiflorum, 8-12g of bitter apricot seed, 5-7g of safflower, 5-7g of fried bitter orange and 5-7g of liquorice; mixing the above components, soaking in water, decocting for two times, adding water with a volume which is 8 times of the total weight of the raw materials for decocting for 1 h to obtain a first decoction, adding water with a volume which is 6 times of the total weight of the raw materials for decocting for 0.5h to obtain a second decoction, mixing the two decoctions, and filtering to obtain the final product; the weight volume is solids in g and liquids in ml.

2. The traditional Chinese medicine for treating intestinal constipation according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 55g of snakegourd fruit, 5g of Chinese angelica, 8g of astragalus, 8g of raw bighead atractylodes rhizome, 5g of polygonum multiflorum, 8g of bitter apricot seed, 5g of safflower, 5g of fried bitter orange and 5g of liquorice.

3. The traditional Chinese medicine for treating intestinal constipation according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 60g of snakegourd fruit, 6g of Chinese angelica, 10g of astragalus, 10g of raw bighead atractylodes rhizome, 6g of polygonum multiflorum, 10g of bitter apricot seed, 6g of safflower, 6g of fried bitter orange and 6g of liquorice.

4. The traditional Chinese medicine for treating intestinal constipation according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 65g of snakegourd fruit, 7g of Chinese angelica, 12g of astragalus, 12g of raw bighead atractylodes rhizome, 7g of polygonum multiflorum, 12g of bitter apricot seed, 7g of safflower, 7g of fried bitter orange and 7g of liquorice.

5. The traditional Chinese medicine for treating intestinal constipation according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 58g of snakegourd fruit, 7g of Chinese angelica, 11g of astragalus, 9g of raw bighead atractylodes rhizome, 5g of polygonum multiflorum, 9g of bitter apricot seed, 6g of safflower, 7g of fried bitter orange and 5g of liquorice.

6. The traditional Chinese medicine for treating intestinal constipation according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 62g of snakegourd fruit, 5g of Chinese angelica, 9g of astragalus, 11g of raw bighead atractylodes rhizome, 6g of polygonum multiflorum, 11g of bitter apricot seed, 5g of safflower, 6g of fried bitter orange and 7g of liquorice.