CN117491617A - Analysis equipment for simultaneously measuring CRP (common protein) by blood routine analysis - Google Patents
Analysis equipment for simultaneously measuring CRP (common protein) by blood routine analysis Download PDFInfo
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- CN117491617A CN117491617A CN202311441547.0A CN202311441547A CN117491617A CN 117491617 A CN117491617 A CN 117491617A CN 202311441547 A CN202311441547 A CN 202311441547A CN 117491617 A CN117491617 A CN 117491617A
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- 108090000623 proteins and genes Proteins 0.000 title abstract description 5
- 238000001514 detection method Methods 0.000 claims abstract description 41
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- 230000033001 locomotion Effects 0.000 claims abstract description 7
- 238000005259 measurement Methods 0.000 claims abstract 10
- 238000012360 testing method Methods 0.000 claims description 56
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- 238000003860 storage Methods 0.000 claims description 14
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- 238000001125 extrusion Methods 0.000 claims description 9
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- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
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- 239000003219 hemolytic agent Substances 0.000 description 4
- 238000009534 blood test Methods 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 238000010827 pathological analysis Methods 0.000 description 2
- 239000011435 rock Substances 0.000 description 2
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
- G01N2001/386—Other diluting or mixing processes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N2021/8411—Application to online plant, process monitoring
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4737—C-reactive protein
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Abstract
The invention discloses analysis equipment for routinely analyzing blood and simultaneously measuring CRP (common protein), and relates to the field of blood analysis, comprising a mechanism shell, wherein the outer surface of the mechanism shell is provided with a central controller capable of operating the movement of the internal components of the mechanism shell; the detection mechanism is arranged inside the mechanism shell and comprises a separator. This to blood routine analysis simultaneous measurement CRP's analytical equipment can make waiting to detect the serum tiling on the observation dish to the bottom surface of observation dish, and the light that transmission light emitter took place will pass the observation dish and receive serum CRP to take place crookedly, thereby the transmission light detector will gather the crooked feedback of these light and obtain the quantity of antigen-antibody complex such as CRP, through waiting to detect the serum tiling increase light irradiation area earlier and detect again, effectively avoided antigen-antibody complex such as a plurality of CRP laminating each other and lead to partial CRP to be difficult to by the light irradiation lead to the problem of the deviation of CRP quantity and the actual existence that detects.
Description
Technical Field
The invention relates to the technical field of blood analysis, in particular to analysis equipment for simultaneously measuring CRP (common protein) in conventional blood analysis.
Background
In the medical field, a certain treatment method can be obtained from pathological analysis of blood, the number of various cells in the blood can assist in judging infection, inflammation, postoperative recovery condition and blood diseases, the clinical diagnosis of a hospital usually needs to obtain detection results of detection items such as blood routine and reactive protein (CRP) of a patient at the same time at present, the CRP is usually used as a judgment index of inflammation sensitive symptoms, the blood routine is the examination for judging blood conditions and diseases by observing the number change and morphological distribution of blood cells, along with the development of modernization and automation of examination, the conventional blood examination is finished by machine detection, and the rapid test mode of the number of CRP at present is to obtain the number of CRP by irradiating detection reagents through a transmission light detector and feeding back the refraction condition of light.
The utility model discloses a through retrieving patent number CN110286243B an automatic blood routine detector of loading and uninstalling sample test tube, including the base and set up the analyzer body and add uninstallation device on the base, add the uninstallation device including rotating the column spinner that sets up on the base, can follow a plurality of test tube covers of sliding setting in the column spinner outer fringe along vertical direction, be used for promoting the test tube cover that rotates to the sampling tube position so that the sampling tube inserts the loading spoon that samples in the corresponding sample test tube and be used for opening the test tube cover that the sample test tube corresponds after the sample test tube by the bottom so that the blood routine analysis detection of sample test tube after the sample test tube is deviate from, the device can optimize current big batch sample by a wide margin, simple construction and use cost are cheap.
In order to obtain a specific condition of a disease from pathological analysis of blood, a medical staff generally needs to use a blood routine analyzer to detect the blood, in the embodiment of the patent, although the blood routine analysis detection of the existing large-batch sample can be greatly optimized, but the problem that deflection exists in bending feedback of a transmission light detector ray due to relatively dense CRP in a test tube during CRP detection is difficult to avoid, the current blood routine analyzer can detect the blood routine and CRP value at the same time, when the CRP value is detected, the CRP number in the test tube is usually detected by using a radiation bending feedback mode, namely, the CRP number in the test tube is usually detected by irradiating light rays to the surface of the test tube through transmission, the light rays irradiated to the CRP will be bent, and the number of antigen-antibody complexes such as CRP is obtained through collecting the bending feedback of the light rays, but when the antigen-antibody complexes such as CRP in the test tube are relatively dense, the antigen-antibody complexes such as CRP are mutually attached to cause that part of CRP is difficult to be irradiated by the light rays, and the CRP number obtained through bending feedback of the light rays deviates from the actual situation at the moment, and the analysis result of the number is inaccurate. To this end, we provide an analytical device for routine analysis of blood while measuring CRP that solves the above problems.
Disclosure of Invention
The invention aims to make up the defects of the prior art, provides analysis equipment for carrying out routine analysis on blood and simultaneously measuring CRP, and solves the problem that deflection exists in bending feedback of rays of a transmission light detector due to denser CRP in a test tube during CRP detection.
The invention provides the following technical scheme for solving the technical problems: an analytical device for routine analysis of blood while measuring CRP, comprising:
a mechanism housing having an outer surface mounted with a central controller operable to move internal components of the mechanism housing;
the detection mechanism is arranged in the mechanism shell and comprises a separator, and can grab a sample test tube to move and centrifuge blood in the test tube;
the shaking mechanism is arranged in the mechanism shell and comprises a swinging frame, a lifting frame and a fixing plate, and can be used for flatly paving a reagent to be detected on the observation vessel;
go up unloading mechanism, go up unloading mechanism and set up the inside at the mechanism shell, go up unloading mechanism and include the liftout plate, go up unloading mechanism and can go up the unloading to the observation dish.
Further, the separator is installed at the inner bottom wall of mechanism's shell, annotate the liquid machine is installed to the right flank of separator, the conventional detection device of blood is installed to the left flank of separator, the inner bottom wall fixedly connected with test tube rack of mechanism's shell, the robotic arm with test tube rack looks adaptation is installed to the inner bottom wall of mechanism's shell.
Through adopting above-mentioned technical scheme, the controller on the control mechanism shell, control robotic arm snatch two test tubes in the test tube rack and place in the separator to steerable annotate liquid machine and pour into respectively into the test tube on two separators with buffer solution, diluent and the hemolytic agent that remains in the liquid machine into, and carry out rotatory separation to the mixed solution in the test tube through the separator and bleed.
Further, the first electronic slide rail of interior roof fixedly connected with of mechanism's shell, advance kind and snatch the subassembly in the bottom of first electronic slide rail, the second electronic slide rail of interior roof fixedly connected with of mechanism's shell, advance kind and annotate the liquid subassembly in the bottom of second electronic slide rail, transmission light emitter is installed to the interior bottom wall of mechanism's shell, the interior roof fixedly connected with of mechanism's shell and transmission light detector of transmission light emitter looks adaptation.
Through adopting above-mentioned technical scheme, when need carrying out blood routine detection, direct control advances a kind and snatchs the subassembly and remove the test tube in snatching the separator along electric slide rail one and place in blood routine detection device and carry out blood routine detection, when need carrying out CRP detection, control advances a kind and annotate the serum that liquid subassembly removed in the test tube on the separator along electric slide rail two, and inject the serum after the extraction on the observation dish on the swing frame, and through starting transmission light emitter emission light, the light of emission will pass the observation dish and receive serum CRP to take place to crookedly, transmission light detector will gather the crooked feedback of these light and thereby obtain the quantity of antigen-antibody complex such as CRP.
Further, fixed plate fixed connection is at the inner wall of mechanism's shell, swing frame and fixed plate rotate to be connected, swing frame's surface fixedly connected with two slipmats, the surface fixedly connected with swash plate of crane, the surface mounting of crane has infrared probe, the surface fixedly connected with of fixed plate and the inductor of infrared probe looks adaptation.
Through adopting above-mentioned technical scheme, inductor and infrared probe are located same horizontal plane, and when needs keep the swing frame to be located the level and carry out CRP detection, remove the crane and drive infrared probe and remove, when the infrared ray that infrared probe launched was detected by the inductor, will control motor one and stop the operation, the crane is in the horizontality this moment.
Further, the surface fixedly connected with two slide bars of swing frame, the interior bottom wall of mechanism's shell passes through two arc slide rails of support fixedly connected with, two slide bar sliding connection respectively is at the inner wall of two arc slide rails, the surface fixedly connected with of crane two drag the slide rail, two slide bar sliding connection respectively is at the inner wall of two drag the slide rail.
Through adopting above-mentioned technical scheme, when two drag slide rail reciprocating motion from top to bottom, two drag slide rail drive swinging arms reciprocating rotation from top to bottom through dragging two slide bars, and the swinging arms will drive the observation dish on it and rotate and rock, make the bottom surface of waiting to detect serum tiling to the observation dish on the observation dish.
Further, two first limit rods are fixedly connected to the inner bottom wall of the mechanism shell, the first limit rods are in sliding connection with the lifting frame, a straight sliding rail is fixedly connected to the outer surface of the lifting frame, a first motor is fixedly connected to the inner bottom wall of the mechanism shell, a crank is fixedly connected to the output end of the first motor, and the crank is in sliding connection with the straight sliding rail.
Through adopting above-mentioned technical scheme, through the setting of gag lever post one, stability when increasing the crane reciprocates, take place the skew when avoiding the crane to remove, behind the starter motor one, the motor one will rotate the crank and drive crane reciprocating motion from top to bottom through straight slide rail.
Further, the surface fixedly connected with two sliders of liftout plate, the surface fixedly connected with of fixed plate two fixed rails, two the slider respectively with two fixed rail sliding connection, the surface fixedly connected with extrusion piece of liftout plate, the top of fixed plate is provided with the storage tube, the fixed intercommunication of storage tube is at the interior roof of mechanism's shell.
Through adopting above-mentioned technical scheme, pile up a plurality of observation dishes in the storage cylinder, remove the observation dish that control extrusion piece roof pressure storage cylinder bottom when the liftout plate removes.
Further, the surface fixedly connected with motor two of fixed plate, the output fixedly connected with threaded rod of motor two, the threaded rod rotates the surface of connecting at the fixed plate, the surface fixedly connected with screw thread piece of liftout plate, the spout with screw thread piece looks adaptation is seted up to the surface of fixed plate, screw thread piece passes through the spout and fixed plate sliding connection of fixed plate, threaded rod and screw thread piece threaded connection, the surface fixedly connected with two strengthening ribs of fixed plate, two the equal fixed connection of strengthening rib is at the inner wall of mechanism's shell.
Through adopting above-mentioned technical scheme, through the setting of strengthening rib, increase the stability of fixed plate, behind the starter motor two, motor two drives the threaded rod rotation, and the threaded rod rotation will drive the ejector plate through the thread piece and remove.
Further, the surface fixedly connected with two L templates of swing frame, two the equal fixedly connected with of inner wall of L template two gag lever posts two, every the equal fixedly connected with of gag lever post two is at the surface of swing frame, two the top of L template all is provided with the grip block, two the grip block respectively with two sets of gag lever post two sliding connection.
Through adopting above-mentioned technical scheme, when the new observation dish in extrusion piece roof pressure storage section of thick bamboo promotes to the swing frame, extrusion piece contact earlier and extrusion auxiliary tank removes and drives the grip block and keep away from the observation dish, cancel two grip blocks to the centre gripping effect of old observation dish, new observation dish roof pressure swing frame is last to the swash plate on and the landing outside to the mechanism shell.
Further, two the surface of grip block is all fixedly connected with auxiliary groove, every the surface of gag lever post two all overlaps and is equipped with expansion spring, two sets of expansion spring respectively fixed connection at the surface of two L templates, two sets of expansion spring respectively with two grip block fixed connection.
Through adopting above-mentioned technical scheme, through telescopic spring's setting, when extrusion piece does not push up the auxiliary tank, the grip block receives the spring pressure of two telescopic springs, makes two grip blocks centre gripping observe the ware, prevents to observe the ware and take place the position offset with the swing frame when rotating from top to bottom.
Compared with the prior art, the analysis device for simultaneously measuring CRP by routine analysis of blood comprises the following components
The beneficial effects are that:
1. according to the invention, the shaking mechanism and the feeding and discharging mechanism are arranged, serum to be detected is dripped on the observation dish on the swinging frame, the motor is started to drive the straight sliding rail to move up and down through the crank, so that the two dragging sliding rails are driven to move up and down in a reciprocating manner through dragging the two sliding bars, the swinging frame drives the observation dish on the swinging frame to rotate and shake, the serum to be detected on the observation dish is paved on the bottom surface of the observation dish, light rays generated by the transmission light emitter penetrate through the observation dish and are bent by serum CRP, the transmission light detector is used for collecting bending feedback of the light rays, so that the quantity of antigen-antibody complexes such as CRP is obtained, and the problem that part of CRP is difficult to detect due to light irradiation due to mutual lamination of antigen-antibody complexes such as CRP is effectively avoided.
2. According to the invention, the detection mechanism is arranged, the central controller capable of operating the internal components of the mechanism shell to move is arranged on the outer surface of the mechanism shell, the controller of the mechanism shell can control the mechanical arm to grab test tubes in the test tube rack and place the test tubes in the separator, the liquid injection machine can be controlled to respectively inject buffer liquid, diluent and hemolytic agent remained in the liquid injection machine into the test tubes on the separator, then the separator is controlled to rotate to separate serum from blood in the test tubes, when the blood routine detection is required, the sample injection grabbing component is directly controlled to move along the first electric slide rail to grab the test tubes in the separator to carry out the blood routine detection, when the CRP detection is required, the sample injection liquid injection component is controlled to move along the second electric slide rail to extract the serum in the test tubes on the separator, and the extracted serum is injected into the observation dish on the swing frame to wait for detection, and the device can simultaneously carry out the blood routine detection and the CRP detection.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.
Drawings
FIG. 1 is a schematic perspective view of the present invention;
FIG. 2 is a schematic perspective view of the interior of the mechanism housing of the present invention;
FIG. 3 is a schematic perspective view of a detection mechanism according to the present invention;
FIG. 4 is a perspective linkage schematic diagram of the shaking mechanism and the loading and unloading mechanism of the present invention;
FIG. 5 is a schematic diagram of a three-dimensional structure of the feeding and discharging mechanism of the present invention;
FIG. 6 is a schematic perspective view of a transmissive light emitter and a transmissive light detector of the present invention;
FIG. 7 is a schematic perspective view of a wobble mechanism according to the present invention;
FIG. 8 is a schematic diagram of a split structure of the wobble mechanism of the present invention;
FIG. 9 is a schematic perspective view of the feeding and discharging mechanism of the present invention;
FIG. 10 is a schematic diagram of a split structure of the feeding and discharging mechanism of the present invention;
FIG. 11 is a schematic perspective view of a clamping block according to the present invention;
fig. 12 is a schematic perspective view of a threaded rod according to the present invention.
In the figure:
1. a mechanism housing;
2. a detection mechanism; 21. a separator; 22. a test tube placing rack; 23. a mechanical arm; 24. a liquid injection machine; 25. blood routine detection device; 26. an electric slide rail I; 27. sampling grabbing components; 28. an electric sliding rail II; 29. a sample injection and liquid injection assembly;
3. a shaking mechanism; 301. a swing frame; 302. a slide bar; 303. an arc-shaped slide rail; 304. a lifting frame; 305. dragging the sliding rail; 306. a first limit rod; 307. a straight slide rail; 308. a first motor; 309. a crank; 310. a fixing plate; 311. an infrared probe; 312. an inductor; 313. an anti-slip pad; 314. a sloping plate;
4. a loading and unloading mechanism; 401. an ejector plate; 402. a slide block; 403. a fixed rail; 404. a screw block; 405. a second motor; 406. a threaded rod; 407. reinforcing ribs; 408. extruding a block; 409. an L-shaped plate; 410. a clamping block; 411. a second limiting rod; 412. an auxiliary groove; 413. a telescopic spring; 414. a storage cylinder;
5. a transmissive light emitter; 6. a transmission photodetector.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1, 2, 3 and 6, the present invention provides a technical solution: the utility model provides an analytical equipment for conventional analysis of blood while measuring CRP, including mechanism's shell 1, the inside of mechanism's shell 1 is provided with detection mechanism 2, detection mechanism 2 includes separator 21, separator 21 installs the interior bottom wall of mechanism's shell 1, annotate liquid machine 24 is installed to the right flank of separator 21, blood conventional detection device 25 is installed to the left flank of separator 21, the interior bottom wall fixedly connected with test tube rack 22 of mechanism's shell 1, robotic arm 23 with test tube rack 22 looks adaptation is installed to the interior bottom wall of mechanism's shell 1, the controller on mechanism's shell 1 is controlled robotic arm 23 and two test tubes in test tube rack 22 are placed in the separator 21, and steerable annotate liquid machine 24 and pour into respectively into the buffer solution that remains in the liquid machine 24, diluent and hemolytic agent into the test tube on two separators 21, and carry out the rotatory separation serum to the mixed liquor in the test tube through separator 21.
The inner top wall of the mechanism shell 1 is fixedly connected with an electric slide rail I26, a sample injection grabbing component 27 is installed at the bottom of the electric slide rail I26, an electric slide rail II 28 is fixedly connected to the inner top wall of the mechanism shell 1, a sample injection and liquid injection component 29 is installed at the bottom of the electric slide rail II 28, a transmission light emitter 5 is installed on the inner bottom wall of the mechanism shell 1, a transmission light detector 6 matched with the transmission light emitter 5 is fixedly connected to the inner top wall of the mechanism shell 1, when blood routine detection is needed, the sample injection grabbing component 27 is directly controlled to move along the electric slide rail I26 to grab a test tube in the separator 21 to be placed in the blood routine detection device 25 for blood routine detection, when CRP detection is needed, the sample injection and liquid injection component 29 is controlled to move along the electric slide rail II 28 to extract serum in the test tube on the separator 21, the extracted serum is injected onto a sight glass on the swing frame 301, the transmitted light emitter 5 is started to emit light, the transmitted light passes through the sight glass and is bent by serum CRP, and the transmission light detector 6 is fed back by bending the collected light rays to obtain the quantity of antigen antibody complexes such as CRP.
Referring to fig. 4, 7 and 8, a shaking mechanism 3 is disposed in the mechanism housing 1, the shaking mechanism 3 includes a shaking frame 301, a lifting frame 304 and a fixing plate 310, the fixing plate 310 is fixedly connected to an inner wall of the mechanism housing 1, the shaking frame 301 is rotationally connected to the fixing plate 310, two anti-slip pads 313 are fixedly connected to an outer surface of the shaking frame 301, friction force of the observation dish on the shaking frame 301 is increased through arrangement of the anti-slip pads 313, an inclined plate 314 is fixedly connected to an outer surface of the lifting frame 304, an infrared probe 311 is mounted on an outer surface of the lifting frame 304, an inductor 312 matched with the infrared probe 311 is fixedly connected to an outer surface of the fixing plate 310, the inductor 312 and the infrared probe 311 are located on the same horizontal plane, when the shaking frame 301 is required to be kept to be located horizontally for CRP detection, the lifting frame 304 is moved to drive the infrared probe 311 to move, and when infrared rays emitted by the infrared probe 311 are detected by the inductor 312, the first control motor 308 is stopped to operate, and the lifting frame 304 is in a horizontal state.
The outer surface fixedly connected with two slide bars 302 of swing frame 301, the interior bottom wall of mechanism shell 1 passes through two arc slide rails 303 of support fixedly connected with, two slide bars 302 are sliding connection respectively at the inner wall of two arc slide rails 303, the surface fixedly connected with of crane 304 two slide rails 305 that drag, two slide bars 302 are sliding connection respectively at the inner wall of two slide rails 305 that drag, when two slide rails 305 reciprocating motion about dragging, two slide rails 305 that drag drive swing frame 301 through dragging two slide bars 302 reciprocate from top to bottom, swing frame 301 will drive the observation dish on it and rotate and rock, make the serum tiling that waits to detect on the observation dish to the bottom surface of observation dish.
The inner bottom wall of the mechanism shell 1 is fixedly connected with two first limit rods 306, the two first limit rods 306 are both in sliding connection with the lifting frame 304, the outer surface of the lifting frame 304 is fixedly connected with a straight slide rail 307, the inner bottom wall of the mechanism shell 1 is fixedly connected with a first motor 308, the output end of the first motor 308 is fixedly connected with a crank 309, the crank 309 is in sliding connection with the straight slide rail 307, stability of the lifting frame 304 during up-and-down movement is improved through the arrangement of the first limit rods 306, deflection of the lifting frame 304 during movement is avoided, after the first motor 308 is started, the first motor 308 rotates the crank 309 and drives the lifting frame 304 to reciprocate up and down through the straight slide rail 307.
Referring to fig. 5, 9 and 12, a loading and unloading mechanism 4 is disposed in the mechanism housing 1, the loading and unloading mechanism 4 includes an ejector plate 401, two sliders 402 are fixedly connected to an outer surface of the ejector plate 401, two fixing rails 403 are fixedly connected to an outer surface of the fixing plate 310, the two sliders 402 are respectively slidably connected to the two fixing rails 403, an extrusion block 408 is fixedly connected to an outer surface of the ejector plate 401, a storage cylinder 414 is disposed above the fixing plate 310, the storage cylinder 414 is fixedly connected to an inner top wall of the mechanism housing 1, a plurality of observation dishes are stacked in the storage cylinder 414, and when the ejector plate 401 moves, the extrusion block 408 is controlled to push the observation dishes at the bottom end of the storage cylinder 414.
The surface fixedly connected with motor two 405 of fixed plate 310, the output fixedly connected with threaded rod 406 of motor two 405, threaded rod 406 rotates the surface of connecting at fixed plate 310, the surface fixedly connected with screw thread piece 404 of ejector plate 401, the spout with screw thread piece 404 looks adaptation is seted up to the surface of fixed plate 310, screw thread piece 404 passes through the spout of fixed plate 310 and fixed plate 310 sliding connection, threaded rod 406 and screw thread piece 404 threaded connection, the surface fixedly connected with two strengthening ribs 407 of fixed plate 310, two strengthening ribs 407 are all fixedly connected at the inner wall of mechanism shell 1, through the setting of strengthening rib 407, increase the stability of fixed plate 310, behind the start motor two 405, motor two 405 drive threaded rod 406 rotation, screw thread piece 406 rotation will drive ejector plate 401 through screw thread piece 404 and remove.
Referring to fig. 10 and 11, the outer surface of the swinging frame 301 is fixedly connected with two L-shaped plates 409, the inner walls of the two L-shaped plates 409 are fixedly connected with two limiting rods 411, each limiting rod 411 is fixedly connected to the outer surface of the swinging frame 301, clamping blocks 410 are arranged above the two L-shaped plates 409, the two clamping blocks 410 are respectively and slidably connected with the two limiting rods 411, when a new observation dish in the pressing storage cylinder 414 of the pressing block 408 pushes towards the swinging frame 301, the pressing block 408 firstly contacts with and presses the auxiliary groove 412 to drive the clamping blocks 410 to be far away from the observation dish, the clamping effect of the two clamping blocks 410 on the old observation dish is cancelled, the old observation dish on the swinging frame 301 is pushed onto the inclined plate 314 and slides to the outer part of the mechanism shell 1, the outer surfaces of the two clamping blocks 410 are fixedly connected with the auxiliary groove 412, the outer surfaces of each limiting rod 411 are respectively sleeved with telescopic springs 413, the two groups of telescopic springs 413 are respectively and slidably connected to the outer surfaces of the two L409, and the two groups of telescopic springs 413 are respectively and fixedly connected with the two clamping blocks 410, and the two clamping blocks 410 are not pressed by the telescopic springs 412, so that the two clamping blocks 410 are prevented from being rotated to press the two observation dishes when the two clamping blocks 410 are not pressed against the telescopic springs, and the two clamping blocks are not pressed against the clamping blocks 301, and are prevented from rotating.
Working principle: when in use, the controller on the shell 1 of the control mechanism is used for controlling the mechanical arm 23 to grasp the test tube in the test tube rack 22 and put the test tube in the separator 21, controlling the liquid injector 24 to inject the buffer liquid, the diluent liquid and the hemolytic agent remained in the liquid injector 24 into the test tube on the separator 21 respectively, then controlling the separator 21 to rotate so as to separate serum from the blood in the test tube, when the conventional blood test is needed, directly controlling the sample grabbing component 27 to move along the first electric slide rail 26 so as to grab the test tube in the separator 21 and put the test tube in the conventional blood test device 25 for the conventional blood test, when the CRP test is needed, controlling the sample injecting component 29 to move along the second electric slide rail 28 so as to extract the serum in the test tube on the separator 21, and injecting the extracted serum into the observation dish on the swinging frame 301 to wait for the test, starting the first motor 308 to drive the straight slide rail 307 to move up and down through the crank 309, the two dragging slide rails 305 are simultaneously reciprocated up and down, thereby driving the swinging frame 301 to reciprocate up and down by dragging the two slide bars 302, the swinging frame 301 drives the observation dish on the swinging frame 301 to rotate and shake, the serum to be detected on the observation dish is tiled to the bottom surface of the observation dish, the light rays generated by the transmission light emitter 5 pass through the observation dish and are bent by serum CRP, the transmission light detector 6 collects the bending feedback of the light rays so as to obtain the quantity of antigen-antibody complexes such as CRP, the second motor 405 is controlled to drive the threaded rod 406 to rotate after detection, the threaded rod 406 rotates to drive the ejector plate 401 to move through the threaded block 404, the new observation dish in the pressing storage cylinder 414 is pushed to the swinging frame 301, the old observation dish on the new observation dish pressing swinging frame 301 is pushed to the inclined plate 314 and slides to the outside of the mechanism shell 1, the new observation dish will be located the detection of waiting next time on swing frame 301 this time, and the device is through waiting to detect the serum tiling increase light irradiation area earlier and detect again, has effectively avoided the antigen-antibody complex such as a plurality of CRPs to laminate each other and has led to part CRP to be difficult to by the light irradiation and lead to the problem of the CRP quantity of detecting and the deviation that exists in fact.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Claims (10)
1. An analysis apparatus for routine analysis of blood while measuring CRP, comprising:
a mechanism housing (1), wherein a central controller capable of operating the movement of the internal components of the mechanism housing (1) is arranged on the outer surface of the mechanism housing (1);
the detection mechanism (2) is arranged inside the mechanism shell (1), the detection mechanism (2) comprises a separator (21), and the detection mechanism (2) can grab a sample test tube to move and centrifuge blood in the test tube;
the shaking mechanism (3), the shaking mechanism (3) is arranged in the mechanism shell (1), the shaking mechanism (3) comprises a swinging frame (301), a lifting frame (304) and a fixed plate (310), and the shaking mechanism (3) can be used for tiling a reagent to be detected on an observation dish;
go up unloading mechanism (4), go up unloading mechanism (4) and set up the inside at mechanism housing (1), go up unloading mechanism (4) including liftout plate (401), go up unloading mechanism (4) and can go up the unloading to the observation dish.
2. An analytical device for simultaneous measurement of CRP for routine analysis of blood according to claim 1, wherein: the utility model discloses a blood normal detection device, including mechanism's shell (1), separator (21), annotate liquid machine (24) are installed to the right flank of separator (21), blood normal detection device (25) are installed to the left flank of separator (21), the interior bottom of mechanism's shell (1) fixedly connected with test tube rack (22), robotic arm (23) with test tube rack (22) looks adaptation are installed to the interior bottom of mechanism's shell (1).
3. An analytical device for simultaneous measurement of CRP for routine analysis of blood according to claim 1, wherein: the utility model discloses a mechanism, including mechanism shell (1), transmission light emitter (5) are installed to the interior roof fixedly connected with electronic slide rail (26) of mechanism shell (1), advance kind and snatch subassembly (27) are installed to the bottom of electronic slide rail (26), the interior roof fixedly connected with electronic slide rail two (28) of mechanism shell (1), advance kind and annotate liquid subassembly (29) are installed to the bottom of electronic slide rail two (28), transmission light detector (6) of transmission light emitter (5) looks adaptation are installed to the interior roof fixedly connected with of mechanism shell (1).
4. An analytical device for simultaneous measurement of CRP for routine analysis of blood according to claim 1, wherein: fixed plate (310) fixed connection is at the inner wall of mechanism's shell (1), swing frame (301) and fixed plate (310) rotate to be connected, the surface fixedly connected with two slipmats (313) of swing frame (301), the surface fixedly connected with swash plate (314) of crane (304), the surface mounting of crane (304) has infrared probe (311), the surface fixedly connected with of fixed plate (310) is with inductor (312) of infrared probe (311) looks adaptation.
5. An analytical device for simultaneous measurement of CRP for routine analysis of blood according to claim 1, wherein: the outer surface fixedly connected with two slide bars (302) of swing frame (301), interior bottom wall of mechanism shell (1) is through support fixedly connected with two arc slide rail (303), two slide bar (302) are sliding connection respectively at the inner wall of two arc slide rail (303), the surface fixedly connected with of crane (304) is two and is dragged slide rail (305), two slide bar (302) are sliding connection respectively at the inner wall of two and dragging slide rail (305).
6. An analytical device for simultaneous measurement of CRP for routine analysis of blood according to claim 1, wherein: the mechanism comprises a mechanism shell (1), wherein two first limit rods (306) are fixedly connected to the inner bottom wall of the mechanism shell (1), the two first limit rods (306) are both in sliding connection with a lifting frame (304), a straight slide rail (307) is fixedly connected to the outer surface of the lifting frame (304), a first motor (308) is fixedly connected to the inner bottom wall of the mechanism shell (1), a crank (309) is fixedly connected to the output end of the first motor (308), and the crank (309) is in sliding connection with the straight slide rail (307).
7. An analytical device for simultaneous measurement of CRP for routine analysis of blood according to claim 1, wherein: the outer surface fixedly connected with two sliders (402) of liftout plate (401), the outer surface fixedly connected with of fixed plate (310) two fixed track (403), two slider (402) respectively with two fixed track (403) sliding connection, the outer surface fixedly connected with extrusion piece (408) of liftout plate (401), the top of fixed plate (310) is provided with storage cylinder (414), the interior roof at mechanism's shell (1) is fixed to intercommunication to storage cylinder (414).
8. An analytical device for simultaneous measurement of CRP for routine analysis of blood according to claim 1, wherein: the utility model discloses a mechanism for fixing a motor, including fixed plate (310), threaded rod (406), ejector plate (401), threaded block (404) are connected in the surface of fixed plate (310) in a rotating way to the output fixedly connected with threaded rod (406) of fixed plate (310), the spout with threaded block (404) looks adaptation is seted up to the surface of fixed plate (310), threaded block (404) pass through the spout of fixed plate (310) and fixed plate (310) sliding connection, threaded rod (406) and threaded block (404) threaded connection, the surface fixedly connected with of fixed plate (310) two strengthening ribs (407), two equal fixed connection of strengthening rib (407) are at the inner wall of mechanism housing (1).
9. An analytical device for simultaneous measurement of CRP for routine analysis of blood according to claim 1, wherein: the outer surface fixedly connected with two L template (409) of swing frame (301), two the equal fixedly connected with of inner wall of L template (409) two gag lever post two (411), every two gag lever post two (411) are all fixedly connected with at the surface of swing frame (301), two the top of L template (409) all is provided with grip block (410), two grip block (410) respectively with two sets of gag lever post two (411) sliding connection.
10. An analytical device for simultaneous measurement of CRP for routine analysis of blood according to claim 9, wherein: the outer surfaces of the two clamping blocks (410) are fixedly connected with auxiliary grooves (412), the outer surfaces of the two limiting rods (411) are sleeved with telescopic springs (413), the two groups of telescopic springs (413) are respectively and fixedly connected to the outer surfaces of the two L-shaped plates (409), and the two groups of telescopic springs (413) are respectively and fixedly connected with the two clamping blocks (410).
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| CN117491617B (en) | 2024-05-03 |
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