CN117440755A - Ophthalmic lens with antibacterial and/or antiviral properties and method for manufacturing same - Google Patents
Ophthalmic lens with antibacterial and/or antiviral properties and method for manufacturing same Download PDFInfo
- Publication number
- CN117440755A CN117440755A CN202280035951.5A CN202280035951A CN117440755A CN 117440755 A CN117440755 A CN 117440755A CN 202280035951 A CN202280035951 A CN 202280035951A CN 117440755 A CN117440755 A CN 117440755A
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- coating
- ophthalmic lens
- layer
- metal
- biocidal component
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- 238000001350 scanning transmission electron microscopy Methods 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
Abstract
The present invention relates to an ophthalmic lens comprising at least one antimicrobial and/or antiviral coating and to a method for manufacturing the same.
Description
The present invention relates to an ophthalmic lens comprising at least one biocidal component acting as an antibacterial and/or antiviral agent, and to a method for manufacturing such an ophthalmic lens.
As mentioned in s.galdiero et al, silver Nanoparticles as Potential Antiviral Agents [ silver nanoparticles as potential antiviral agents ], molecular [ Molecules ]2011,16,8894-8918, viral infections present significant challenges to global health, especially because of the emergence of resistant strains of virus and adverse side effects associated with long-term use that continue to slow down the use of effective antiviral therapies. Newly emerging and reappeared viruses are considered a persistent threat to human health because they can adapt to their current host, switch to a new host, and escape strategies for antiviral measures. Viruses may occur due to host, environmental, or vector changes, and new pathogenic viruses may be produced in humans from existing human viruses or animal viruses. Viral diseases such as SARS coronavirus, west nile virus, monkey pox virus, hantavirus, nipah virus, hendra virus, chikungunya virus, influenza virus, have recently originated in birds or pigs and have entered the world population.
Organic antibacterial agents, photocatalytic materials and metal compounds have been widely studied and have demonstrated their antibacterial and/or antiviral effects.
US 5,454,886A assigned to knoop-iist pharmaceutical company (Nucryst Pharmaceuticals corp.) discloses an antimicrobial coating deposited as a metal film on at least one surface of a medical device by physical vapor deposition techniques under conditions that create atomic disorder in the antimicrobial coating. Atomic disorder (including point defects, vacancies, line defects, interstitial atoms, amorphous regions, grain boundaries or subgrain boundaries in the crystal lattice) is responsible for sustained release of metallic species when contacted with an alcohol or water-based electrolyte (including body fluids or body tissues) according to US 5,454,886A when compared to the normal ordered crystalline state found in bulk metallic materials or alloys. To create atomic disorder during the deposition process, for example, the temperature of the surface to be coated may be maintained such that the ratio of substrate temperature to metal melting point in Kelvin degrees is less than about 0.5. Atomic disorder can also be achieved by preparing a composite metal material (i.e., a material containing at least one antimicrobial metal in a metal matrix that contains atoms or molecules other than the antimicrobial metal). Silver may be used as the antimicrobial metal. For the preparation of the composite metal material, at least one antimicrobial metal is co-deposited or sequentially deposited with at least one other inert, biocompatible metal or with an oxide, nitride, carbide, boride, sulfide, hydride or halide of the at least one antimicrobial metal and/or inert metal. Metals useful in antimicrobial coatings should have antimicrobial action and should be biocompatible. Typically, the antimicrobial coating has a film thickness of less than 1 μm and no greater than 10 μm.
WO 2019/082001A1 assigned to university of dolichos (Politecnico di Torino) discloses an air filter comprising a breathable substrate and an antiviral coating. An antiviral coating having a thickness from 15nm to 500nm comprises nanoclusters of a first glass, ceramic, glass-ceramic material or matrix (preferably silica) and a plurality of second metallic materials (preferably copper, zinc or silver). Furthermore, WO 2019/082001A1 discloses a method of applying an antiviral coating onto a substrate. The method comprises a co-deposition or co-sputtering process of nanoclusters of at least a first glass, ceramic, glass-ceramic material or matrix, preferably silicon dioxide, and at least a plurality of second metallic materials, preferably silver, copper or zinc, on a substrate.
Miola et al in "Silver nanocluster-silica composite antibacterial coatings for materials to be used in mobile telephones [ silver nanocluster-silica composite antibacterial coating for materials used in mobile phones ]", applied Surface Science [ applied surface science ]313 (2014) 107-115 disclose the deposition of antibacterial coatings on several different polymers used in mobile phone parts such as screens, covers and microphone felts by co-sputtering techniques, these antibacterial coatings containing different numbers of metallic silver nanoclusters embedded in a silica matrix. The sputtering parameters have been varied to achieve different coating thicknesses and silver contents in order to meet the antimicrobial, aesthetic and functional requirements of each component.
Gladskikh et al studied the optical properties of silver clusters in a silica matrix. 2017Nanocon conference paper "Optical Properties of Silver and Gold Clusters in Silica Matrices [ optical Properties of silver and gold clusters in silica matrix", by boolean Nuo in the republic of the European Union, 10.18 to 20 days]Experimental studies on the absorption and luminescence properties of silver nanoclusters embedded in a silica matrix are described on pages 821 to 825. For this purpose, the authors succeeded in reducing the metal and SiO in vacuo 2 Co-deposition onto silica substrates produced SiO's with varying amounts of silver 2 A film. Films with silver content have three absorption spectrum peaks in the near UV range and two luminescence spectrum peaks in the visible range. Gladskikh et al attribute these spectral features to the presence of silver nanoclusters of different sizes in the film. Luminescence was observed only in samples with silver content less than 2.2%. Luminescence quenching in films with higher silver content is associated with non-radiative energy transfer between close-packed particles. Thermal annealing results in the formation of larger particles and changes both the absorption spectrum and the emission spectrum of the film.
GB 2372044B assigned to Samsung SDI co.ltd., discloses a functional film arrangement comprising a substrate and an overlayer deposited on the substrate A transition layer, the transition layer comprising: a first component which is at least one dielectric material, such as SiO x Wherein x is>1, a step of; and a second component, which is, for example, silver. The first component and the second component have a gradually changing content gradient in the thickness direction of the film, and the content of the first component is largest at the face of the transition layer closest to the substrate.
JP 2020142494A assigned to the company of the eatery optics (Ito Optical ind.) describes an antimicrobial transparent laminate comprising a single-layer or multi-layer Optical inorganic vapor deposited film on at least one side of a transparent base material, wherein the Optical inorganic vapor deposited film has a satisfactory film design comprising silicon dioxide (SiO 2 ) As the final layer. The final layer of the vapor deposited film is formed of a composite layer comprising an antimicrobial vapor deposited layer and a protective SiO adjacent to the outside thereof 2 A layer comprising a metal-loaded inorganic antimicrobial agent, wherein the SiO 2 Used as a matrix. The metal-loaded inorganic antimicrobial agent may, for example, comprise Ag + -ions. The ophthalmic lenses may be formed from antimicrobial transparent laminates.
CN 106772713A assigned to shanghai ken optical limited responsibilities corporation (Shanghai Conant Optics co.ltd.) discloses an ophthalmic lens comprising an antimicrobial coating. The coating of the lens substrate comprises the following layer sequence (starting from the surface of the lens substrate): a hard coat layer, an antireflection layer including two to seven layers, an antibacterial layer, an adhesive layer, and a top layer. According to CN 106772713a, the adhesive layer should increase the adhesion between the antimicrobial layer and the top layer. The antimicrobial layer may be silver, copper, zinc, titanium, one or more metal oxides coated on the anti-reflective film. The adhesion layer may be made of one or more oxides of silica, alumina, zirconia on the surface of the antimicrobial layer.
US10,221,093B2 assigned to the Saint Gobain group (Saint Gobain s.a.) describes a (preferably transparent) glazing substrate, such as a window glazing, comprising a thin film multilayer coated on one face thereof. The thin film multilayer comprises at least one metal functional film based on silver or made of silver and having a thickness between 7nm and 20nm and two anti-reflection coatings. The anti-reflective coatings each include at least one anti-reflective film. The metal functional film is located between two anti-reflection coatings. The multilayer comprises two discontinuous metal films each having a thickness between 0.5nm and 5 nm. The lower discontinuous metal film is located between the face and the unique or first metal functional film counted from the face, and the upper discontinuous metal film is located above the unique or last metal functional film counted from the face. The lower discontinuous metal film and the upper discontinuous metal film are each based on or made of silver. The lower discontinuous metal film and the upper discontinuous metal film are each a continuous layer having a surface area occupation factor in the range of 50% to 98% and are in the form of interconnected islands with uncovered areas between islands.
An antireflection film is known from US2020/209436A1 assigned to Fuji Holdings corp (Fuji Holdings corp.), which is provided on a transparent base material such as a lens. The antireflection film includes an intermediate layer, a silver-containing metal layer containing silver, and a dielectric layer. An intermediate layer, a silver-containing metal layer, and a dielectric layer are laminated in this order on one side of the substrate. The intermediate layer is a multilayer film having at least two layers in which a high refractive index layer having a relatively high refractive index and a low refractive index layer having a relatively low refractive index are alternately laminated. The dielectric layer has an air-exposed surface, and the dielectric layer is a multilayer film including a silicon-containing oxide layer, a magnesium fluoride layer, and an adhesion layer disposed between the silicon-containing oxide layer and the magnesium fluoride layer and configured to increase adhesion between the silicon-containing oxide layer and the magnesium fluoride layer. The adhesion layer is provided separately from the silicon-containing oxide layer and the magnesium fluoride layer and is made of a metal oxide.
US10,527,760B2 assigned to escilor describes an ophthalmic lens comprising a transparent substrate, for example part of a liquid crystal display device of a portable telephone device having a front main face and a rear main face, at least one of these main faces being coated with a multilayer antireflective coating comprising a stack of at least:
(i) A wetting layer;
(ii) A metal layer, wherein the metal is selected from silver, gold or copper or mixtures thereof;
(iii) And a protective layer capable of avoiding oxidation of the metal layer.
The wetting layer (i) is in direct contact with the metal layer (ii). The metal layer (ii) has a physical thickness ranging from 6nm to 20nm, and the multilayer antireflective coating has a total thickness ranging from 50nm to 150 nm.
US2015/0044482 A1 assigned to Don's responsibility limited describes an optical coating structure comprising:
(i) A substrate;
(ii) An anti-reflective coating disposed on the substrate, the anti-reflective coating covering the substrate;
(iii) A base coating layer covering the anti-reflection coating layer;
(iv) An antimicrobial coating disposed on the base coating, the antimicrobial coating being an intermediate layer; a protective coating covering the antimicrobial coating.
Optionally, a superhydrophobic coating and/or an anti-fingerprint coating may be provided on the protective coating. Illustratively, the substrate is described as comprising a transparent polymeric resin, toughened or semi-toughened glass. The substrate may comprise chemically tempered glass. In addition, the substrate may be disposed on a display device having a touch screen panel. The antimicrobial coating may be formed by a vacuum vapor deposition process. The antimicrobial coating may comprise silver (Ag) based materials and the like. The antimicrobial coating may comprise silver ions. Silver ions may be formed on the base coating layer comprising silicon dioxide. Silver ions can be combined with small openings in the silica surface. The protective coating may be disposed over the antimicrobial coating and may completely or partially cover the antimicrobial coating. The protective coating may be formed on the antimicrobial coating by vacuum vapor deposition. The protective coating may comprise a silica-based material.
CN 210534467U assigned to xiaomen duo optical science co.ltd (Xiamen DuocaiIOptical tech.co.ltd.) discloses seawater corrosion resistant antimicrobial ophthalmic lenses comprising a base material coated on its front surface with a hard coating, an anti-reflective coating, an anti-seawater coating and a water-repellent coating. On the rear surface, the substrate is coated with a hard coat layer, an adhesive coat layer, an antibacterial coat layer, and a waterproof coat layer. The antimicrobial coating is a silver film. The adhesion coating between the hard coating and the antimicrobial coating may enhance the adhesion of the antimicrobial coating.
WO 2020/138469 A1 assigned to Hoya Corporation discloses an ophthalmic lens which achieves both high antimicrobial and antistatic properties by the same outermost coating layer of the ophthalmic lens. The outermost coating contains tungsten oxide particles, tin oxide particles, and silver particles, and a binder component (such as silicon oxide). The adhesive component should improve the adhesion of the outermost coating. Preferably, the thickness of the outermost coating layer is in the range of 3nm to 30 nm. It is further preferred that the particle size of the tungsten oxide particles, tin oxide particles and silver particles is smaller than the thickness of the outermost coating layer to avoid the formation of protrusions on the outermost surface thereof. The particle size of the tungsten oxide particles, tin oxide particles and silver particles is preferably from 2nm to 5nm. In order to obtain good antimicrobial properties, the outermost coating layer comprises tungsten oxide particles, preferably in the range of 0.25 to 0.80wt. -%. In order to obtain good antistatic properties, the outermost coating layer comprises tin oxide particles, preferably in the range of 0.10 to 0.35wt. -%. In order to improve the antimicrobial properties, the outermost coating comprises silver particles, preferably in the range of 0.025wt. -% to 0.10wt. -%. The outermost coating layer may be formed by dip coating. The optical characteristics of existing coating designs should not deteriorate due to the thinner thickness of the outermost coating.
KR 200375582 Y1 of Yang Won Dong discloses glasses or sunglasses in which a material of sunglasses made of metal, glass or plastic resin contains nano silver.
International patent application PCT/CN 2020/090962 discloses an ophthalmic lens comprising a substrate and a layer sequence deposited on both surfaces (i.e. front and rear surfaces) of said substrate. The layer sequence deposited at least on the front surface comprises at least one antibacterial and/or antiviral coating.
International patent application PCT/CN 2020/104011 discloses an ophthalmic lens comprising a substrate and a layer sequence deposited on both surfaces (i.e. front and rear surfaces) of said substrate. The rear surface of the substrate is covered with a hard coat layer, an adhesion layer, an anti-reflective (AR) coating stack, and optionally an outermost top coat layer functionally constituting a cleaning coating. Preferably, the front surface of the substrate is covered with the same layer sequence, except that at least the outermost top coat additionally comprises at least one biocidal component.
International patent application PCT/CN 2020/128598 discloses an ophthalmic lens comprising at least an anti-reflective coating or mirror, each comprising a plurality of stacked layers, wherein the outermost stacked layers constitute SiO of silver (Ag) 2 A substrate.
WO 2007/101055 A1 discloses an antimicrobial lens comprising a lens member and at least a first coating. The antimicrobial agent may be unreleasably disposed within the first coating or the antimicrobial agent may be incorporated into the lens material itself.
JP 2005034685A discloses a method of coating an ophthalmic lens with silver-based titanium oxide in a thickness of about 0.1 μm to 1.0 μm. A silver-based titanium oxide coating layer should be formed on the pretreatment coating layer to fill the surface irregularities.
CN 105068270A discloses an antimicrobial ophthalmic lens comprising an ophthalmic lens body, the upper and lower surfaces of which are provided with antimicrobial layers, [0010]. The antimicrobial layer may be a transparent nano silver silica gel coating having a thickness of 30 to 40 microns, or a transparent nano silane film layer. The antimicrobial film may be provided by vacuum coating.
CN 211928330U discloses an ophthalmic lens with good antibacterial effect. The ophthalmic lens includes an outer antimicrobial layer and an inner antimicrobial layer, both made of transparent nano silver silicon and each having a thickness of 30 microns.
The difficulty in designing ophthalmic lenses is meeting the needs of the wearer of the spectacles for optical characteristics as well as for health-related characteristics.
It is therefore an object of the present invention to provide an ophthalmic lens which effectively prevents the residual and spread of bacteria and/or viruses on at least one ophthalmic lens surface, in particular on the front and/or rear surface of the ophthalmic lens, thereby avoiding the addition of further coatings in existing coating stacks or existing coating designs. Another object is to provide an efficient and highly reproducible method of manufacturing ophthalmic lenses that is effective in preventing the residual and spread of bacteria and/or viruses on at least one ophthalmic lens surface, in particular on the front and/or rear surface of the ophthalmic lens.
This object is solved by an ophthalmic lens having the features of independent claims 1, 7 and 11, 44, 50 and 54 and by a method for manufacturing an ophthalmic lens according to independent claims 14, 15, 18, 30 and 37, 66, 67, 70 and 82.
Preferred embodiments which can be realized in isolation or in any arbitrary combination are listed in the dependent claims.
The following definitions are used within the scope of this description:
spectacle lens base material
The term "ophthalmic lens substrate" means in the context of the present invention any uncoated or pre-coated ophthalmic lens blank. Furthermore, the term "ophthalmic lens substrate" means in the context of the present invention any uncoated or pre-coated ophthalmic lens, the uncoated or pre-coated front surface of which and/or the uncoated or pre-coated rear surface of which is/are preferably to be coated with at least one coating layer, so that a coated lens with the desired properties is preferably obtained. According to ISO 13666:2019 (E), section 3.2.13, the front surface is the surface of the lens intended to be fitted away from the eye. According to ISO 13666:2019 (E), section 3.2.14, the rear surface is the surface of the lens intended to be fitted closer to the eye.
In particular, as the spectacle lens base material, the following can be used: an uncoated or pre-coated blank defined in section 3.8.1 of ISO 13666:2019 (E) as a piece of optical material having an optical finished surface for manufacturing a lens; an uncoated or pre-coated single light blank defined in section 3.8.2 of ISO 13666:2019 (E) as a blank having a finished surface of a single nominal surface power; an uncoated or pre-coated multifocal blank defined in section 3.8.3 of ISO 13666:2019 (E) as a blank having a finished surface with two or more distinctly separate portions of different diopters or powers; an uncoated or pre-coated varifocal blank defined in section 3.8.4 of ISO 13666:2019 (E) as a blank having a smooth variation of spherical power over part or all of its area without discontinuities, thus giving a finished surface of more than one desired power; an uncoated or pre-coated progressive power blank defined as a variable power blank in section 3.8.5 of ISO 13666:2019 (E), wherein the finished surface is a progressive power surface; an uncoated or pre-coated decreasing power blank defined as a variable power blank in section 3.8.6 of ISO 13666:2019 (E), wherein the finished surface is a decreasing power surface; an uncoated or pre-coated finished lens defined in section 3.8.7 of ISO 13666:2019 (E) as a lens having its final optical surface on both sides; an uncoated or pre-coated, non-cut lens defined in section 3.8.8 of ISO 13666:2019 (E) as a finished lens before edging; or uncoated or pre-coated edging lenses, defined in section 3.8.9 of ISO 13666:2019 (E), as finished lenses edging to final size and shape. If one of the aforementioned blanks is pre-coated, the corresponding finished surface comprises at least one coating. If one of the aforementioned lenses is pre-coated, at least one side thereof comprises at least one coating.
Preferably, the ophthalmic lens substrate is an uncoated or pre-coated finished lens or an uncoated or pre-coated, non-cut lens.
Uncoated or pre-coated ophthalmic lens substrates can be categorized as afocal lenses (section 3.6.3 according to ISO 13666:2019 (E)) or corrective lenses, i.e. lenses having diopters (section 3.5.3 according to ISO 13666:2019 (E)) with nominal diopters of zero. Furthermore, uncoated or pre-coated ophthalmic lens substrates can be categorized as single-lens according to section 3.7.1 of ISO 13666:2019 (E); section 3.7.2 of ISO 13666:2019 (E) can be categorized as a single lens in a specific position; section 3.7.3 according to ISO 13666:2019 (E) can be categorized as multifocal lenses; section 3.7.4 according to ISO 13666:2019 (E) can be classified as a bifocal lens; section 3.7.5 according to ISO 13666:2019 (E) can be categorized as trifocal lenses; section 3.7.6 according to ISO 13666:2019 (E) can be categorized as a fusion multifocal lens; section 3.7.7 according to ISO 13666:2019 (E) can be categorized as a variable power lens; section 3.7.8 according to ISO 13666:2019 (E) can be categorized as progressive power lens; or section 3.7.9 according to ISO 13666:2019 (E) may be categorized as a progressive power lens.
Furthermore, uncoated or pre-coated ophthalmic lens substrates can be categorized as protective lenses according to section 3.5.4 of ISO13666:2019 (E); section 3.5.5 according to ISO13666:2019 (E) can be classified as an absorbing lens; section 3.5.6 according to ISO13666:2019 (E) can be categorized as tinted lenses; section 3.5.7 according to ISO13666:2019 (E) can be classified as transparent lenses; section 3.5.8 of ISO13666:2019 (E) can be categorized as uniformly tinted lenses; section 3.5.9 according to ISO13666:2019 (E) can be categorized as gradient tinted lenses; section 3.5.10 according to ISO13666:2019 (E) can be classified as a dual gradient tinted lens; section 3.5.11 according to ISO13666:2019 (E) can be categorized as photochromic lenses; or according to ISO13666:2019 (E) section 3.5.12.
The uncoated or pre-coated ophthalmic lens substrate is preferably based on an optical material, which is defined according to section 3.3.1 of ISO13666:2019 (E) as a transparent material that can be manufactured into an optical component. The uncoated or pre-coated ophthalmic lens substrate may be made of the following materials: glass according to section 3.3.2 of ISO13666:2019 (E), i.e. a material formed by fusion, cooling and solidification of inorganic substances without crystallization; and/or organic hard resins according to ISO13666:2019 (E) section 3.3.3, such as thermosetting hard resins, i.e. plastic materials consisting essentially of organic polymers, which have been cured to a substantially non-fusible and insoluble state and cannot be efficiently reformed upon heating; thermoplastic hard resins according to section 3.3.4 of ISO13666:2019 (E), i.e. plastic materials consisting essentially of organic polymers, which can be repeatedly softened by heating and hardened by cooling and in the softened state can be shaped into lenses or blanks by flow molding, extrusion or shaping; and/or photochromic materials according to section 3.3.5 of ISO13666:2019 (E), i.e. materials whose transmittance is reversibly changed according to the irradiation and wavelength of the light radiation falling thereon.
Preferably, the uncoated or pre-coated ophthalmic lens substrate is based on at least one of the optical materials mentioned in table 1, particularly preferably on at least one of the plastic materials.
Table 1: examples of optical materials for blanks or lenses
* Based on sodium D line
If the uncoated or pre-coated ophthalmic lens substrate comprises at least two different optical materials selected from a) at least one glass and at least one thermosetting hard resin or from b) at least one glass and at least one thermoplastic hard resin, the at least one glass preferably comprises at least one thin glass. An ophthalmic lens substrate comprising at least two different optical materials comprises as its front and/or rear surface at least one glass, preferably at least one thin glass. The at least one thermosetting hard resin or the at least one thermoplastic hard resin may be categorized as one of the blanks or one of the lenses described above. Preferably, the at least one thermosetting hard resin or the at least one thermoplastic hard resin may each be categorized as an uncoated or pre-coated finished lens or an uncoated or pre-coated uncut lens. If one of the aforementioned blanks is pre-coated, the corresponding final optical surface comprises at least one coating. If one of the aforementioned lenses is pre-coated, at least one side thereof comprises at least one coating. Needless to say, the surfaces facing or adjacent to each other in the resulting ophthalmic lens substrate must have their final optical surfaces and optionally at least one coating thereof prior to assembly of the at least two different optical materials.
The at least one thin glass may be based on various glass compositions. Preferably, the glass composition of each thin glass is based on borosilicate glass, aluminoborosilicate glass, or borosilicate glass free of alkali metals, more preferably, the glass composition is based on borosilicate glass. The thickness of the at least one thin glass is preferably in the range from 30 μm to 300 μm, further preferably in the range from 40 μm to 280 μm, further preferably in the range from 50 μm to 260 μm, more preferably in the range from 60 μm to 240 μm and most preferably in the range from 90 μm to 220 μm. The thickness of the at least one thin glass is preferably determined by the corresponding planar thin glass prior to forming into its final form and shape. Preferably, the thickness of the at least one thin glass is measured using a Filmetrics F10-HC instrument from Filmetrics. Preferably, the thickness of the at least one thin glass is an average thickness. The at least one thin glass surface, preferably the front and rear surfaces of the thin glass, each have an average surface roughness of preferably Ra <1nm. Further preferably, the average surface roughness Ra of the at least one thin glass surface is in the range from 0.1nm to 0.8nm, more preferably in the range from 0.3nm to 0.7nm and most preferably in the range from 0.4nm to 0.6 nm. The given value of the average surface roughness Ra is preferably applied to the at least one thin glass surface prior to shaping into the final form and shape. Depending on the shaped body used for shaping, the given value of the average surface roughness Ra can also be applied to the thin glass surface in its final form and shape. The average surface roughness Ra of the at least one thin glass surface is preferably determined using a NewView 7100 instrument from Ke company (Zygo Corporation).
The at least one thin glass preferably comprises a surface topography selected from at least one of: spherical surface, defined as a portion of the inner or outer surface of a sphere according to ISO 13666:2019 (E), section 3.4.1; aspherical surfaces, defined according to ISO 13666:2019 (E), section 3.4.3, are surfaces of revolution having a continuously variable curvature over all or part of their area; a torus, according to ISO 13666:2019 (E), section 3.4.6, defined as a surface having mutually perpendicular and circular main meridians with unequal curvatures; non-toroidal surfaces, defined according to ISO 13666:2019 (E), section 3.4.7 as surfaces having mutually perpendicular principal meridians of unequal curvature, wherein at least one principal meridian has asphericity; and a zoom level, according to ISO 13666:2019 (E), section 3.4.10, defined as a surface having a smooth variation of surface power over a portion or all of its area without discontinuities. Preferably, the surface topography of the front and back surfaces of the at least one thin glass is the same. Further preferably, the surface topography of the at least one thin glass is spherical.
Thin glass is commercially available, for example, under the following names: D263T eco, D263 LA eco, D263M, AF eco, AS 87eco, B270I, each commercially available from schottky group (schottky AG), or Corning Willow Glass or Corning Gorilla Glass, each commercially available from Corning inc (Corning inc.).
In an ophthalmic lens substrate comprising a) at least one thin glass and at least one thermosetting hard resin or b) at least one thin glass and at least one thermoplastic hard resin, the at least one thin glass may be transparent according to the definition given in section 3.5.7 for a transparent lens according to ISO 13666:2019 (E); the definition given for an absorbing lens in section 3.5.5 may be absorbing according to ISO 13666:2019 (E); the definition given for tinted lenses in section 3.5.6 may be tinted according to ISO 13666:2019 (E); or according to ISO 13666:2019 (E), the definition given for photochromic lenses in section 3.5.11 may be photochromic. Preferably, the at least one thin glass is transparent within the definition of transparent lens according to ISO 13666:2019 (E), section 3.5.7, i.e. not intended color/hue when transmitted.
In an ophthalmic lens substrate comprising a) at least one thin glass and at least one thermosetting hard resin or b) at least one thin glass and at least one thermoplastic hard resin, the at least one thermosetting hard resin or the at least one thermoplastic hard resin may each be transparent, absorbing, tinted, photochromic, each according to the definition given in the aforementioned ISO 13666:2019 (E), and/or the at least one thermosetting hard resin or the at least one thermoplastic hard resin may be polarized according to the definition given in ISO 13666:2019 (E), section 3.5.12. Preferably, the at least one thermosetting hard resin or the at least one thermoplastic hard resin is transparent.
Coating layer
In the context of the present invention, the term "coating" means any coating applied to the front and/or rear surface of an ophthalmic lens substrate to result in a coated lens, defined as a lens to which one or more layers have been added to alter one or more characteristics of the lens, according to ISO 13666:2019 (E), section 3.18.1.
The coating is preferably at least one coating selected from the group consisting of: at least one hard coating defined in ISO 13666:2019 (E), section 3.18.2 as a coating on the surface of an organic lens, intended to enhance the abrasion resistance of the surface during normal use; at least one anti-reflective coating defined in ISO 13666:2019 (E), section 3.18.3 as a coating on the surface of the lens, intended to reduce light reflected from its surface; at least one cleaning coating, defined in ISO 13666:2019 (E), section 3.18.4 as a coating on the surface of the lens, intended to make the surface repel dust and grease and/or make it easier to clean; at least one hydrophobic coating, defined in ISO 13666:2019 (E), section 3.18.5 as a coating on the surface of the lens, intended to repel water droplets; at least one hydrophilic coating, defined in ISO 13666:2019 (E), section 3.18.6 as a coating on the surface of the lens, intended to be very wettable, so that any water droplets thereon spread and coalesce into a uniform film on the surface; at least one anti-fog coating, defined in ISO 13666:2019 (E), section 3.18.7 as a hydrophobic or hydrophilic coating on the surface of the lens, intended to reduce blurring caused by condensed water vapor droplets on the lens surface when the relatively cool lens is placed in a warmer, humid environment; at least one antistatic coating, defined in ISO 13666:2019 (E), section 3.18.8 as a coating on the surface of the lens, intended to reduce static electricity on the surface in order to reduce attraction to dust; at least one specular coating; at least one primer coating; at least one photochromic coating; at least one photochromic primer coating; at least one antimicrobial coating, preferably defined as a coating having a kill rate of at least one type of bacteria of 95% or more, preferably 99.9% or more, measured according to ISO 22196:2011 (E); and at least one antiviral coating, preferably defined as a coating having a kill rate of greater than or equal to 95%, preferably greater than or equal to 99.9%, for at least one type of virus, such as an enveloped virus, measured according to ISO 21702:2019 (E).
In particular, the at least one photochromic coating comprises any coating that provides the ophthalmic lens with the characteristics of the photochromic material as defined in section 3.3.5 of ISO 13666:2019 (E). Preferably, the at least one photochromic coating should not comprise a coating in which the photochromic effect is negligible (i.e. because the change in light transmittance between the faded and darkened state is for example lower than 1.1). Further preferably, the at least one photochromic coating may comprise one of the photochromic coatings disclosed in EP 1 433 814 A1, EP 1 602 479A1 or EP 1 561 571 A1.
In particular, the at least one photochromic primer coating may for example comprise the photochromic primer coating disclosed in WO 03/058300A1, page 22, line 3 to page 23, line 13. In ophthalmic lenses comprising at least one photochromic primer coating and at least one photochromic coating, it is preferred that the at least one photochromic coating is its outermost coating, i.e. the coating is furthest from the surface of the ophthalmic lens substrate with which it is coated. In an ophthalmic lens comprising at least one photochromic primer coating, at least one photochromic coating and at least one hard-coat, preferably the at least one photochromic primer coating is a coating immediately adjacent to, but not necessarily adjacent to, the surface of the ophthalmic lens coated therewith and the at least one hard-coat is its outermost coating. Preferably, only the front surface of the ophthalmic lens substrate comprises at least one photochromic coating, preferably one photochromic coating, and optionally at least one photochromic primer layer, preferably one photochromic primer layer.
In particular, the at least one primer coating is preferably based on at least one primer coating composition comprising i) at least one aqueous aliphatic, cycloaliphatic, aromatic or heteroaromatic polyurethane dispersion, at least one aqueous aliphatic, cycloaliphatic, aromatic or heteroaromatic polyurea dispersion, at least one aqueous aliphatic, cycloaliphatic, aromatic or heteroaromatic polyurethane-polyurea dispersion, and/or at least one aqueous aliphatic, cycloaliphatic, aromatic or heteroaromatic polyester dispersion, preferably at least one aqueous aliphatic polyurethane dispersion or at least one aqueous aliphatic polyester dispersion and more preferably at least one aqueous aliphatic polyurethane dispersion, and ii) at least one solvent, and iii) optionally at least one additive.
In particular, the at least one hard coating may be selected from at least one of the hard coatings disclosed in US2005/0171231 A1, US 2009/0189303A1, US 2002/011390 A1 and EP 2 578 649 A1. The at least one hard coating is preferably based on i) at least one hard coating composition comprising:
a) a) at least one Si (OR) of the formula (I) 1 )(OR 2 )(OR 3 )(OR 4 ) Wherein R is 1 、R 2 、R 3 And R is 4 May be the same or different and is selected from alkyl, acyl, cycloalkyl or aryl, each of which may be optionally substituted, and/or
b) At least one hydrolysate of the at least one silane derivative of formula (I), and/or
c) At least one condensation product of the at least one silane derivative of the formula (I), and/or
d) Any mixture of components a) to c);
b) a) at least one compound of the formula (II) R 6 R 7 3-n Si(OR 5 ) n Wherein R is 5 Selected from alkyl, acyl, cycloalkyl or aryl, each of which may be optionally substituted, R 6 Is an organic radical containing at least one epoxide group, R 7 Selected from alkyl, cycloalkyl or aryl, each of which may be optionally substituted, n is 2 or 3; and/or
b) At least one hydrolysate of the at least one silane derivative of formula (II), and/or
c) At least one condensation product of the at least one silane derivative of the formula (II), and/or
d) Any mixture of components a) to c);
c) At least one colloidal inorganic oxide, hydroxide, oxide hydrate, fluoride and/or oxyfluoride;
d) At least one epoxy compound having at least two epoxy groups; and
e) At least one catalyst system comprising at least one lewis acid and at least one thermally latent lewis acid base adduct;
Or ii) at least one hard coating composition comprising
A) a) at least one compound of the formula (III) R 1 R 2 3-n Si(OR 3 ) n Wherein R is 1 Including alkyl, cycloalkyl, acyl, aryl or heteroaryl, each of which may be substituted, R 2 Is an organic residue containing an epoxy group, R 3 Including alkyl, cycloalkyl, aryl or heteroaryl groups, each of which may be substituted, n=2 or 3, and/or
b) At least one hydrolysate of the silane derivative of formula (III), and/or
c) At least one condensation product of the silane derivative of formula (III), and/or
d) Any mixture of components a) to c);
b) At least one colloidal inorganic oxide, hydroxide, oxide hydrate, fluoride and/or oxyfluoride;
c) At least one epoxy component comprising at least two epoxy groups; and
d) At least one catalyst system comprising at least one lewis acid and at least one thermally latent lewis base adduct.
In particular, the at least one anti-reflective coating may comprise one of the anti-reflective coatings disclosed in, for example, EP 2 437 084 A1 or EP 2 850 484 A1 or EP 21158001.4. The anti-reflective coating according to EP 2 437 084 A1 comprises exactly one high refractive index layer having a thickness of less than 40nm, preferably less than 20nm, or at least two high refractive index layers together having a total thickness of less than 40nm, preferably one of the at least two high refractive index layers having a thickness of less than or equal to about 10nm . The at least one high refractive index layer is preferably made of ZrO 2 、TiO 2 Or Ta 2 O 5 And (5) forming. According to EP 2 437 084 A1, fig. 3 or 5, one surface of the spectacle lens substrate each discloses the layer sequence and the corresponding layer thickness of an anti-reflective coating layer on top of and adjacent to the hard coating layer and underneath the superhydrophobic layer, as given in table 2 below.
Table 2: the layer sequence and the layer thickness of the antireflection coating according to fig. 3 and 5 of EP 2 437 084 A1
EP 2 850 484 A1 discloses an antireflective coating having the following characteristics: an average blue reflection factor (Rm, B) in a wavelength range from 420 nm to 450 nm, greater than or equal to 5% for an angle of incidence ranging from 0 ° to 15 °; a spectral reflectance curve for an angle of incidence ranging from 0 ° to 15 °, the reflectance curve having: a maximum reflectance at a wavelength of less than 435nm, and a full width at half maximum (FWHM) of 80 nm or more, and a parameter Δ (θ, θ ') defined by the relation Δ (θ, θ ')=1- [ rθ ' (435 nm)/rθ (435 nm) ] such that the parameter Δ (θ, θ ') is greater than or equal to 0.6, wherein rθ (435 nm) represents a reflectance value of a main face including the filter at 435nm wavelength for the incident angle θ, and rθ ' (435 nm) represents a reflectance value of a main face including the filter at 435nm wavelength for the incident angle θ ', for the incident angle θ ' ranging from 0 ° to 15 °. The described anti-reflective coating may include one of the following layer sequences and layer thicknesses shown in table 3.
Table 3: layer sequence and layer thickness of the antireflective coatings of examples 1 to 3 according to EP 2 850 484 A1
EP 21158001.4 discloses at least one anti-reflective coating, from whichThe coated surface starts with at least one of the following layer sequences given in table 4 below, where λ 0 Preferably selected from any wavelength in the range from 500nm to 600nm (including 500nm and 600 nm), the refractive index of M, L, H is preferably wavelength dependent, M preferably has a wavelength dependent refractive index in the range from 1.632 at 380nm to 1.599 at 780nm, preferably has a wavelength dependent refractive index in the range from 1.614 at 500nm to 1.606 at 600nm, L preferably has a wavelength dependent refractive index in the range from 1.473 at 380nm to 1.456 at 780nm, preferably has a wavelength dependent refractive index in the range from 1.462 at 500nm and 1.459 at 600nm, H preferably has a wavelength dependent refractive index in the range from 2.832 at 380nm to 2.270 at 780nm, preferably has a wavelength dependent refractive index in the range from 2.440 at 500nm and 2.336 at 600 nm. Preferably M is Al x O y Wherein x is 1.5 to 2.5, preferably 2, and y is 2.5 to 3.5, preferably 3; l is SiO z Wherein z is 1.5 to 2.5, preferably 2; h is Ti a O b Wherein a is 0.5 to 1.5, preferably 1, and b is 1.5 to 2.5, preferably 2; or Nb (Nb) c O d Wherein c is 1.5 to 2.5, preferably 2, and d is 4.5 to 5.5, preferably 5. Alternatively, layer M preferably has a wavelength dependent refractive index ranging from 1.750 at 380nm to 1.701 at 780nm, preferably from 1.724 at 500nm to 1.712 at 600 nm. In this alternative, M comprises Pr e O f Or by Pr e O f A composition wherein e is 1.0 to 6 and f is 2.0 to 11, preferably e is 6 and f is 11, or layer M comprises Al x O y And Pr (Pr) e O f Or a mixed oxide of Al and Pr or a mixture of Al x O y And Pr (Pr) e O f Or a mixed oxide of Al and Pr. Commercially available products comprising oxides of Al and Pr are, for example, paso I, paso II and Paso III, all from the company of the family fine (Umicore). An anti-reflective coating comprising at least two M layers and/or at least two H layers, the respective M layers or H layers may comprise or consist of the same composition or different compositions.
Table 4: preferred layer sequence and layer thickness of the antireflective coating of EP 21158001.4
In particular, the at least one mirror coating preferably comprises alternating dielectric layers and/or at least one semitransparent metal layer in the manner of a bragg mirror. The at least one translucent metal layer may comprise, for example, an aluminum layer, a chromium layer, a gold layer and/or a silver layer, preferably a silver layer. The layer thickness of the semitransparent metal layer is typically in the range from 4nm to 48nm, more typically in the range from 8nm to 41nm, and most typically in the range from 17nm to 33 nm. The at least one semi-transparent metal layer is typically applied by a physical vapor deposition method. The at least one specular coating operates in a manner opposite to that of the at least one anti-reflective coating. The term "specular coating" preferably means in the context of the present invention any coating which preferably increases the reflectivity to a value above that of the uncoated ophthalmic lens substrate in the wavelength range of ≡50 nm.
The at least one anti-reflective coating or the at least one mirror coating may preferably be designed with respect to its desired optical properties by using software OptiLayer, version 12.83, from OptiLayer GmbH (85748 near munich, garding b.M hunchen), or Film Center company (Thin Film Center inc.) (2745E cottage (Via Rotunda), talsa (Tucson, AZ USA)), version Essential MacLeod, 11.00.541. For designing the at least one anti-reflection coating and the at least one mirror coating, the respective refractive indices of the composition of the anti-reflection coating or of each individual layer of the at least one mirror coating are preferably assumed to be wavelength dependent.
In particular, the at least one antimicrobial coating is also effective against viruses, or the at least one antiviral coating is also effective against bacteria. Such an antibacterial/antiviral coating is disclosed in, for example, PCT/CN 2020/090962.
Substrate
At least the at least one antimicrobial coating or at least the at least one antiviral coating each comprises at least one medium, at least one agent, at least one active ingredient or at least one biocidal component, which provides antimicrobial and/or antiviral properties to the respective coating or which is responsible for the antimicrobial and/or antiviral properties of the respective coating. The at least one medium, the at least one agent, the at least one active ingredient or the at least one biocidal component is preferably incorporated in the base structure, the base material, the base compound or the base layer in minor amounts. The base structure, base material, base compound or base layer is in the context of the present invention referred to as matrix.
As an alternative to or in addition to the aforementioned at least one antimicrobial coating or at least one antiviral coating, the ophthalmic lens comprises at least one medium, at least one agent, at least one active ingredient or each coating of at least one biocidal component constituting a matrix of the at least one medium, the at least one agent, the at least one active ingredient or the at least one biocidal component providing antimicrobial and/or antiviral properties to the respective coating or causing antimicrobial and/or antiviral properties of the respective coating.
Preferably, the at least one medium, the at least one agent, the at least one active ingredient or the at least one biocidal component is not applied or deposited simultaneously with the substrate.
The at least one medium, the at least one agent, the at least one active ingredient or the at least one biocidal component is hereinafter summarized as at least one biocidal component.
Cluster
In the context of the present invention, "cluster" shall mean a collection of atoms or molecules comprising a group of atoms preferably in the range of 10 2 And 10 (V) 7 Atoms or molecules between each other, more preferably in the range of 10 2 And 2.10 6 Atoms or molecules between each. The atoms or molecules within a cluster may be of the same type or of different types.
Data carrier
A data carrier is any medium capable of holding computer readable data. Examples are hard disk drives and thumb drives for use with computers.
Data carrier signal
A data carrier signal is a structure of how information is transferred or transmitted, for example in a network; the data carrier signal may be transmitted or transmitted as a modulation, such as a binary code or pulse, and may be contained in a data packet.
In a first embodiment of the invention, an ophthalmic lens comprises an ophthalmic lens substrate and
(i) At least one of the layers of the coating,
(ii) At least two individual atoms of at least one biocidal component and/or at least two individual molecules of at least one biocidal component and/or at least two individual clusters of at least one biocidal component, each at least partially located on top of the outermost surface of the at least one coating (i), and
(iii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating, and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens.
If the ophthalmic lens comprises the at least one coating (iii), preferably the at least one coating (iii) is its outermost coating and is preferably selected from the group consisting of at least one cleaning coating (preferably one cleaning coating) and at least one anti-fog coating (preferably one anti-fog coating). If the ophthalmic lens comprises the at least one coating (i) and the at least two separate atoms of the at least one biocidal component and/or the at least two separate molecules of the at least one biocidal component and/or the at least two separate clusters (ii) of the at least one biocidal component, preferably the at least one coating (i) is immediately adjacent to, but not necessarily directly adjacent to, the uncoated or pre-coated surface of the ophthalmic lens substrate comprising the at least one coating (i). The at least two individual atoms of at least one biocidal component and/or the at least two individual molecules of at least one biocidal component and/or the at least two individual clusters of at least one biocidal component (ii) preferably form a discontinuous layer or island-like film on top of the outermost surface of the at least one coating (i). The discontinuous layer or island film preferably has a nominal layer thickness of less than 12nm, more preferably less than 10nm, more preferably less than 8nm, and most preferably less than 6nm. The nominal layer thickness is the layer thickness if a closed or continuous layer has been formed, rather than a discontinuous layer or island film. The nominal layer thickness is preferably measured via a quartz crystal microbalance during deposition of the at least one biocidal component.
The at least one coating (i) preferably comprises at least one coating selected from the group consisting of at least one primer coating, at least one hard coating, at least one anti-reflective coating, at least one mirror coating, at least one antimicrobial coating, at least one antiviral coating, at least one photochromic primer coating and at least one photochromic coating. Further preferably, the at least one coating (i) comprises at least one coating selected from the group consisting of at least one photochromic coating, at least one hard-coating, at least one anti-reflective coating and at least one specular coating. Further preferably, the at least one coating (i) comprises at least one coating selected from the group consisting of at least one hard coating, at least one mirror coating and at least one anti-reflective coating. More preferably, the at least one coating (i) comprises at least one coating selected from the group consisting of at least one hard coating and at least one anti-reflective coating; or at least one coating of the group consisting of at least one anti-reflection coating and at least one mirror coating.
Additionally or alternatively, the at least one coating (i) preferably comprises at least one layer comprising or consisting of: at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal sulfide, at least one metal nitride and/or at least one metal oxynitride (each of silicon). The aforementioned at least one layer preferably has a layer thickness in the range from 10nm to 300nm, further preferably from 20nm to 270nm, further preferably from 30nm to 250nm, more preferably from 40nm to 230nm and most preferably from 50nm to 210 nm. The layer thickness is preferably measured during deposition of the at least one layer via a quartz crystal microbalance or via a transverse and analytical scaled scanning transmission electron microscope (S-TEM) or Transmission Electron Microscope (TEM) picture. The greater the layer thickness of the at least one layer, the greater the contribution of the at least one layer to the scratch resistance of the ophthalmic lens.
The at least one coating (i), preferably one coating (i), may be applied directly to the uncoated or pre-coated front surface and/or the uncoated or pre-coated rear surface of the ophthalmic lens substrate. At least the at least one coating (i), preferably one coating (i), and the at least two separate atoms of at least one biocidal component and/or the at least two separate molecules of at least one biocidal component and/or the at least two separate clusters (ii) of at least one biocidal component are applied onto an uncoated or pre-coated front surface of the ophthalmic lens substrate, thus preferably preventing contact of the ophthalmic lens wearer with, for example, viruses and/or bacteria exhaled by a third person. If the at least one coating (i), preferably one coating (i), is applied to the pre-coated front surface and/or the pre-coated rear surface of the ophthalmic lens substrate, the respective pre-coated surface of the ophthalmic lens preferably comprises at least one coating selected from the group consisting of at least one photochromic primer coating, at least one photochromic coating, at least one primer coating and at least one hard coating. If all of the foregoing coatings are applied to the uncoated front surface and/or the uncoated rear surface of the ophthalmic lens substrate, the at least one photochromic primer coating (preferably one photochromic primer coating) is immediately adjacent and preferably adjacent to the corresponding uncoated surface of the ophthalmic lens substrate, and the at least one hard coating (preferably one hard coating) is the coating furthest from the corresponding uncoated surface of the ophthalmic lens substrate to be coated therewith. Further preferably, the respective pre-coated surface of the ophthalmic lens comprises at least one coating layer selected from the group consisting of at least one primer coating layer and at least one hard coating layer. In this case, the at least one primer coating (preferably one primer coating) is applied immediately and preferably adjacent to the uncoated front surface and/or the uncoated rear surface of the ophthalmic lens substrate, while the at least one hard coating (preferably one hard coating) is the coating furthest from the respective uncoated ophthalmic lens substrate to be coated therewith. Furthermore, provided that the at least one coating (i) preferably comprises at least one layer comprising or consisting of: at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal sulfide, at least one metal nitride and/or at least one metal oxynitride (each of which is silicon), preferably one layer thereof is applied to the uncoated or pre-coated front surface of the ophthalmic lens substrate and/or preferably one layer thereof is applied to the uncoated or pre-coated rear surface of the ophthalmic lens substrate, the respective pre-coated surface of the ophthalmic lens substrate may comprise at least one coating selected from the group consisting of at least one primer coating (preferably one primer coating), at least one hard coating (preferably one hard coating), at least one anti-reflection coating (preferably one anti-reflection coating) and at least one mirror coating (preferably one mirror coating). Preferably, provided that the at least one coating (i) comprises at least one layer comprising or consisting of: at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal sulfide, at least one metal nitride and/or at least one metal oxynitride (each of which is silicon), then the at least one layer (preferably one layer) is applied to the uncoated surface of the ophthalmic lens substrate to be coated therewith.
If both the front and rear surfaces of the ophthalmic lens comprise at least one coating (i), preferably one coating (i), selected from one of the aforementioned coatings, the coating (i) applied to the uncoated or pre-coated front surface of the ophthalmic lens substrate may be of the same type or of a different type than the coating (i) applied to the uncoated or pre-coated rear surface of the ophthalmic lens substrate.
The at least one biocidal component preferably comprises or consists of at least one component selected from the group consisting of at least one metal, at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal sulfide, at least one metal nitride and at least one metal oxynitride, each component comprising or consisting of at least one metal selected from the group consisting of silver, copper, titanium, zinc and iron. Further preferably, each component comprises or consists of at least one metal selected from the group consisting of silver, copper and zinc. More preferably, the at least one biocidal component is applied as at least one metal to or deposited on the outermost surface of the at least one coating (i). The at least one metal preferably comprises or consists of at least one metal selected from the group consisting of silver, copper, titanium, zinc and iron, further preferably comprises or consists of at least one metal selected from the group consisting of silver, copper, zinc and iron, and more preferably comprises or consists of at least one metal selected from the group consisting of silver and zinc. Most preferably, the at least one metal comprises or consists of silver. The outermost surface of the at least one coating (i) is the surface furthest from the surface of the ophthalmic lens substrate, which in turn comprises the at least one coating (i).
The at least one biocidal component is intended to provide an antimicrobial and/or antiviral property to the surface of an ophthalmic lens comprising at least two separate atoms of the at least one biocidal component and/or at least two separate molecules of the at least one biocidal component and/or at least two separate clusters (ii) of the at least one biocidal component.
Preferably, at least two individual atoms of the at least one biocidal component and/or at least two individual molecules of the at least one biocidal component and/or at least two individual clusters (ii) of the at least one biocidal component are each at least partially located on top of the outermost surface of the at least one coating (i). By at least partially on top of the outermost surface of the at least one coating layer (i) is meant that preferably the at least one biocidal component is applied to or deposited on the outermost surface of the at least one coating layer (i), so that preferably the at least two individual atoms and/or the at least two individual molecules and/or the at least two individual clusters are formed on top of the outermost surface of the at least one coating layer (i), but the at least one biocidal component may at least partially at least diffuse into the at least one coating layer (i). Preferably, the at least one biocidal component forms at least two individual atoms and/or at least two individual molecules and/or at least two individual clusters at least within the at least one coating (i), each further preferably at least distributed within the at least one coating (i).
After the at least one biocidal component applied to or deposited on the outermost surface of the at least one coating layer (i) at least partially diffuses at least into the at least one coating layer (i), at least the at least one coating layer (i) constitutes a matrix of the at least one biocidal component. Preferably, the at least one biocidal component is distributed as individual atoms and/or individual molecules and/or individual clusters within at least the at least one coating (i), at least in case the at least one biocidal component at least partially diffuses at least into the at least one coating (i).
The at least one biocidal component applied to or deposited on the outermost surface of the at least one coating (i) may create a concentration gradient within the at least one coating (i) of at least two individual atoms of the at least one biocidal component and/or at least two individual molecules of the at least one biocidal component and/or at least two individual clusters (ii) of the at least one biocidal component as it diffuses into the at least one coating (i). The closer the at least two individual atoms of the at least one biocidal component and/or the at least two individual molecules of the at least one biocidal component and/or the at least two individual clusters (ii) of the at least one biocidal component are to the outermost surface of the at least one coating (i), the higher its concentration within the at least one coating (i) may be.
If the front and/or rear surface of the ophthalmic lens comprises, for example, a hard coating as coating (i) and the at least one biocidal component is applied to or deposited on at least one of the outermost surfaces of the hard coating (i.e. the outermost surface of the front and/or rear surface of the ophthalmic lens), the at least one biocidal component at least partially diffuses into the underlying respective hard coating. Thus, the resulting ophthalmic lens comprises at least at the top of the outermost surface of the respective hard-coating layer and at least two separate atoms of the at least one biocidal component and/or at least two separate molecules of the at least one biocidal component and/or at least two separate clusters of the at least one biocidal component (ii) within the respective hard-coating layer.
In this case, the front surface and/or the rear surface of the ophthalmic lens comprises, as coating (i), for example, at least one layer as described previously, which comprises or consists of: at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal sulfide, at least one metal nitride and/or at least one metal oxynitride (each of which is silicon), said at least one layer preferably does not exhibit or exhibits low anti-reflection properties, and the at least one biocidal component is applied to or deposited on at least one of the outermost surfaces of the layer (i.e. the outermost surface of the front and/or rear surface of the ophthalmic lens), then the at least one biocidal component at least partially diffuses into the respective layer below. Thus, the resulting ophthalmic lens comprises at least at the top of the outermost surface of the respective layer and at least two separate atoms of the at least one biocidal component and/or at least two separate molecules of the at least one biocidal component and/or at least two separate clusters (ii) of the at least one biocidal component within the respective layer.
If the front and/or rear surface of the ophthalmic lens comprises, for example, an anti-reflective coating and/or a specular coating, each coating comprising at least two stacked layers, and the at least one biocidal component is applied to at least one of the outermost surfaces of the outermost stacked layers of the respective coating (i.e. the stacked layer of the at least two stacked layers furthest from the surface of the ophthalmic lens comprising the respective coating), the at least one biocidal component at least partially diffuses at least into the respective outermost stacked layer below and optionally into at least one further stacked layer of the anti-reflective coating and/or the specular coating. Thus, the resulting ophthalmic lens comprises at least two separate atoms of the at least one biocidal component and/or at least two separate molecules of the at least one biocidal component and/or at least two separate clusters of the at least one biocidal component (ii) at least on top of and within the outermost stacked layers of the anti-reflective coating and/or the specular coating.
Preferably, the at least one biocidal component applied to or deposited on the outermost surface of the at least one coating (i) produces individual atoms of the at least one biocidal component and/or individual molecules of the at least one biocidal component and/or individual clusters of the at least one biocidal component.
Preferably, the maximum extension of each individual cluster of the at least one biocidal component is selected from at least one of the following maximum extensions (extensions):
(a) Individual clusters have a maximum spread of less than 20nm,
(b) Individual clusters have a maximum spread of less than 15nm,
(c) Individual clusters have a maximum spread of less than 10nm,
(d) Individual clusters have a maximum spread in the range of 0.5nm to 20nm,
(e) Individual clusters have a maximum spread in the range of 0.5nm to 15nm,
(f) Individual clusters have a maximum spread in the range of 0.5nm to 10nm,
(g) Individual clusters have a maximum spread in the range of 1nm to 20nm,
(h) Individual clusters have a maximum spread in the range of 1nm to 15nm,
(i) Individual clusters have a maximum spread in the range of 1nm to 10 nm.
The aforementioned values or the aforementioned ranges of the maximum extension of the individual clusters apply to the individual clusters on top of the outermost surface of the at least one coating layer (i) and the individual clusters within the at least one coating layer (i), preferably the at least one coating layer (i) to which the at least one biocidal component has been applied or onto which the at least one biocidal component has been deposited. Within at least one coating (i) is meant within a single coating, for example within a hard coating or within a photochromic coating, and within at least one stack of coatings comprising at least two stacked layers, for example within at least the outermost stack of anti-reflective coatings or within at least the outermost stack of mirror coatings. Preferably, the outermost stacked layer is the stacked layer of the respective coating to which the at least one biocidal component has been applied or on which the at least one biocidal component has been deposited. The maximum extension of at least two individual clusters, preferably of each of the plurality of individual clusters, which is preferably selected from at least one of the aforementioned values or the aforementioned ranges, may be the same or different. Preferably, the maximum expansion of at least two individual clusters, preferably each of a plurality of individual clusters, is different from each other.
The maximum extension preferably means a size having the maximum extension. For example, the maximum expansion of a sphere is its diameter. The maximum extension of the ellipsoid is the longest of its symmetry axis or principal axis. Since increasing the maximum expansion of the at least two individual clusters reduces the transmission of the ophthalmic lens, the maximum expansion of the individual clusters preferably may not exceed the aforementioned values or the aforementioned ranges. On the other hand, since the maximum extension of the at least two individual clusters affects in particular the antimicrobial and/or antiviral properties of the ophthalmic lens, their maximum extension should preferably not be below 0.4nm, preferably not below 0.3nm.
The maximum expansion of individual clusters within or on the coating or stack can be measured by advanced analytical techniques, preferably by (scanning) transmission electron microscopy ((S) TEM), e.g. high resolution TEM/STEM with Hitachi HF 5000, by imaging and direct measurement of cluster expansion. Prior to analysis, sections of the respective ophthalmic lenses must be prepared by ultra-thin slicing (e.g., leica EMUC 7), focused ion beam techniques (e.g., zeiss Auriga), ion milling (e.g., IM4000 Plus), or by cooling the respective ophthalmic lenses with liquid nitrogen and manually breaking them.
It should be mentioned here that the at least one coating (i), the at least two individual atoms of the at least one biocidal component and/or the at least two individual molecules of the at least one biocidal component and/or the at least two individual clusters of the at least one biocidal component (ii) and optionally the at least one coating (iii) may be applied to an uncoated or pre-coated front surface and/or an uncoated or pre-coated rear surface of the ophthalmic lens substrate. Preferably, at least the at least one coating (i), at least two separate atoms of the at least one biocidal component and/or at least two separate molecules of the at least one biocidal component and/or at least two separate clusters (ii) of the at least one biocidal component and optionally the at least one coating (iii) are applied onto the uncoated or pre-coated front surface of the ophthalmic lens substrate. This measure should prevent infection by harmful viruses and/or bacteria exhaled by the third party. The uncoated or pre-coated rear surface of the ophthalmic lens substrate may comprise at least one coating (i) and optionally at least one coating (iii) provided that only the at least one coating (i), the at least two individual atoms of the at least one biocidal component and/or the at least two individual molecules of the at least one biocidal component and/or the at least two individual clusters of the at least one biocidal component (ii) and optionally the at least one coating (iii) are applied onto the uncoated or pre-coated front surface of the ophthalmic lens substrate. The type of at least one biocidal component applied to the outermost surface of at least one coating (i) on the front surface and the type of at least one biocidal component applied to the outermost surface of at least one coating (i) on the rear surface may be the same or different, provided that the at least one coating (i), the at least two individual atoms of at least one biocidal component and/or the at least two individual molecules of at least one biocidal component and/or the at least two individual clusters of at least one biocidal component (ii) and optionally the at least one coating (iii) may be applied to the uncoated or pre-coated front surface and the uncoated or pre-coated rear surface of the ophthalmic lens substrate. Preferably, the at least one biocidal component applied to or deposited on the outermost surface of the at least one coating (i) on the front surface of the ophthalmic lens substrate is of the same type as the at least one biocidal component applied to or deposited on the outermost surface of the at least one coating (i) on the rear surface of the ophthalmic lens substrate. Furthermore, the nominal layer thickness on the outermost surface of the at least one coating (i) wherein the at least one biocidal component is applied or deposited on the front surface may be the same or different from the nominal layer thickness on the outermost surface of the at least one coating (i) wherein the at least one biocidal component is applied or deposited on the rear surface. Preferably, the respective nominal layer thicknesses of the at least one biocidal component (i) are the same, provided that the composition and/or order of the stacked layers and their respective composition aspects on at least the uncoated or pre-coated front surface and the uncoated or pre-coated rear surface of the ophthalmic lens substrate are the same, if the at least one biocidal component, further preferably of the same type, is applied or deposited on the respective outermost surface of the at least one coating layer (i). Furthermore, the at least one coating (i) having at least one biocidal component applied on its outermost surface or having at least one biocidal component deposited on its outermost surface may comprise the same type of coating or the same coating or a different type of coating or a different coating on the front and rear surfaces of the ophthalmic lens substrate.
Preferably, the partial diffusion of the at least one biocidal component applied to or deposited on the outermost surface of the at least one coating layer (i) results in a substance proportion of the at least one biocidal component in the at least one coating layer (i) of less than 3.5at%, further preferably less than 3.0at%, and more preferably less than 2.5at%, each with respect to the at least one coating layer (i).
It has been found that the transmission properties as well as the antibacterial and/or antiviral properties are most suitable, provided that the substance proportion of the at least one biocidal component in the at least one coating layer is preferably in the range between 0.001at% and 3.5at%, or in the range between 0.01at% and 3.0at%, or in the range between 0.1at% and 2.5at%, each with respect to the at least one coating layer (i), in order to meet the needs of the spectacle lens wearer.
Preferably, the partial diffusion of the at least one biocidal component applied to or deposited on the outermost surface of the at least one coating (i), preferably of one consisting of a hard coating (i), results in a substance proportion of the at least one biocidal component in the hard coating of less than 3.5at%, further preferably of less than 3.0at% and more preferably of less than 2.5at%, each relative to the hard coating.
The material ratio is preferably defined as the atomic number of the at least one biocidal component divided by the total atomic number in the at least one coating (i). The material ratio is preferably determined by Rutherford Backscattering Spectrometry (RBS). The material proportion is preferably determined within a period of 72 hours, preferably 48 hours, after the at least one biocidal component has been applied or deposited on the outermost surface of the at least one coating layer (i). After this period of time, the substance ratio of the at least one biocidal component may deviate slightly from the above-mentioned range, preferably slightly within a range of ±20%, further preferably within a range of ±15%, each relative to the substance ratio determined during a period of 24 hours after the at least one biocidal component has been applied or deposited on the outermost surface of the at least one coating layer (i). The slight deviation is believed to be due to the further diffusion of the at least one biocidal component into at least one coating underlying the at least one coating (i) and/or into the ophthalmic lens substrate.
If the at least one coating (i) comprises at least one anti-reflective coating and/or at least one specular coating, each of said anti-reflective coating and said specular coating comprising at least two stacked layers, the outermost stacked layer thereof preferably has a thickness within at least one of the following ranges:
a) The outermost stacked layer has a thickness in the range of 1nm to 250nm,
b) The outermost stacked layer has a thickness in the range of 1nm to 140nm,
c) The outermost stacked layer has a thickness in the range of 2nm to 130nm,
d) The outermost stacked layer has a thickness in the range of 3nm to 120nm,
e) The outermost stacked layer has a thickness in the range of 4nm to 115 nm.
The aforementioned outermost stacked layer may be part of the anti-reflective coating stack or part of the mirror coating stack, or the outermost stacked layer may be an additional stacked layer of the anti-reflective coating stack or an additional stacked layer of the mirror coating stack. In both alternatives, the outermost stack is the stack furthest from the surface of the ophthalmic lens substrate with which it is coated. The thickness ranges mentioned above for the outermost stack are also applicable for additional application to the stack layers of a typical anti-reflective coating stack or mirror coating stack. The lower limit is a result of providing sufficient antiviral and/or antibacterial activity. The upper limit is a result of the relationship between providing sufficient antiviral and/or antibacterial activity, providing sufficient transparency to the ophthalmic lens, providing the desired interference effect, and limiting the total content of biocidal compounds to the desired amount.
If the at least one coating (i) comprises at least one anti-reflective coating and/or at least one mirror coating, said anti-reflective coating and said mirror coating each comprising at least two stacked layers, the outermost stacked layer thereof (preferably the outermost stacked layer as described before) comprises or consists of at least one component selected from the group consisting of: at least one metal, at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal nitride, at least one metal oxynitride and at least one metal sulfide, each component comprising or consisting of at least one metal selected from the group consisting of silicon, titanium, aluminum, chromium, indium, tin and zirconium. Preferably, the at least one metal is selected from the group consisting of silicon, titanium and aluminum, more preferably from the group consisting of silicon and titanium. Most preferably, if the at least one coating (i) comprising at least two stacked layers is an anti-reflective coating or a mirror coating, the outermost stacked layer thereof (i.e. the stacked layer is the stacked layer furthest from the uncoated or pre-coated surface of the ophthalmic lens substrate, comprising the anti-reflective coating or the mirror coating) preferably comprises at least one silicon oxide (preferably SiO 2 ) At least one silicon hydroxide, at least one silicon oxide hydrate, at least one silicon nitride, at least one silicon oxynitride and/or at least one silicon sulfideOr consist of, it. Thus, the outermost stacked layer constitutes a silicon-based matrix of the at least one biocidal component, preferably SiO 2 The at least one biocidal component is preferably present within the silicon-based matrix as at least two separate atoms, preferably a plurality of separate atoms, and/or as at least two separate molecules, preferably a plurality of separate molecules, and/or as at least two separate clusters, preferably a plurality of separate clusters. Preferably, in said silicon-based matrix, preferably SiO 2 The mass proportion of the at least one biocidal component in the matrix is within at least one of the following ranges, the at least one biocidal component preferably comprising or consisting of metallic silver and/or metallic copper:
a. on the silicon-based substrate, preferably SiO 2 The biocidal component is present in the matrix at a material fraction of less than 3.5at%,
b. on the silicon-based substrate, preferably SiO 2 The biocidal component is present in the matrix at a material fraction of less than 3.0at%,
c. on the silicon-based substrate, preferably SiO 2 The biocidal component is present in the matrix at a material fraction of less than 2.5at%,
d. On the silicon-based substrate, preferably SiO 2 The mass proportion of the biocidal component in the matrix is in the range between 0.8at% and 3.5at%,
e. on the silicon-based substrate, preferably SiO 2 The substance proportion of the biocidal component in the matrix is in the range between 0.9at% and 3.0at%,
f. on the silicon-based substrate, preferably SiO 2 The biocidal component is present in the matrix in a material proportion in the range between 1.0at% and 2.5 at%.
Preferably, said anti-reflective coating or said mirror coating comprises, in addition to the outermost stacked layer, at least one additional stacked layer comprising at least one silicon oxide (preferably SiO 2 ) At least one silicon hydroxide, at least one silicon hydroxide oxide, at least one silicon nitride, at least one silicon oxynitride and/or at least one silicon sulfide. Preferably, the anti-reflection coating or the mirror coating is coated onBetween the outermost stacked layer and the additional layer at least one stacked layer is comprised or consists of another material, preferably at least one metal oxide, at least one metal hydroxide, at least one metal nitride, at least one metal oxynitride, at least one metal oxide hydrate and at least one metal sulfide, each metal comprising or consisting of titanium, aluminum, indium, tin and/or zirconium. The at least one biocidal component applied to or deposited on the outermost stacked layer may then diffuse into said outermost stacked layer and into said at least one additional stacked layer, both the outermost stacked layer and the additional stacked layer constituting a silicon-based matrix of the at least one biocidal component, preferably SiO 2 A substrate. Preferably, the at least one biocidal component is present as at least two separate atoms, preferably a plurality of separate atoms, and/or as at least two separate molecules, preferably a plurality of separate molecules, and/or as at least two separate clusters, preferably a plurality of separate clusters, constituting the silicon-based matrix, preferably SiO 2 In the outermost stacked layers of matrix and present in the layers constituting the additional silicon-based matrix, preferably the additional SiO 2 In the additional stacked layers of the matrix. Further preferably, at said additional silicon-based matrix, preferably additional SiO 2 The mass proportion of the at least one biocidal component in the matrix is preferably within at least one of the following ranges, the at least one biocidal component preferably comprising or consisting of metallic silver and/or metallic copper:
a) On the additional silicon-based matrix, preferably SiO 2 The biocidal component is present in the matrix at a material fraction of less than 0.25at%,
b) On the additional silicon-based matrix, preferably SiO 2 The biocidal component is present in the matrix at a material fraction of less than 0.2at%,
c) On the additional silicon-based matrix, preferably SiO 2 The biocidal component is present in the matrix at a material fraction of less than 0.15at%,
d) On the additional silicon-based matrix, preferably SiO 2 Said biocidal component in a matrixThe material ratio is in the range between 0.01at% and 0.25at%,
e) On the additional silicon-based matrix, preferably SiO 2 The substance proportion of the biocidal component in the matrix is in the range between 0.01at% and 0.2at%,
f) On the additional silicon-based matrix, preferably SiO 2 The material proportion of the biocidal component in the matrix is in the range between 0.01at% and 0.15at%.
The values and ranges mentioned above for the material proportion of the at least one biocidal component in the additional silicon-based matrix will also apply to the material proportion of the at least one biocidal component in the at least one antireflective coated additional silicon-based matrix or the at least one mirror coated additional silicon-based matrix, respectively.
If the outermost stacked layer of the at least one anti-reflection coating or the outermost stacked layer of the at least one mirror coating each comprises at least one titanium oxide (preferably TiO 2 ) At least one titanium hydroxide, at least one titanium oxide, at least one titanium nitride, at least one titanium oxynitride and/or at least one titanium sulphide, or a mixture thereof, said outermost stacked layer constituting a titanium-based matrix of at least one biocidal component, preferably TiO, applied to or deposited on the surface of the outermost stacked layer 2 A substrate. The at least one biocidal component is present within the titanium-based matrix as at least two separate atoms, preferably a plurality of separate atoms, and/or as at least two separate molecules, preferably a plurality of separate molecules, and/or as at least two separate clusters, preferably a plurality of separate clusters. In the titanium-based matrix, preferably TiO 2 The mass proportion of the at least one biocidal component in the matrix is preferably within at least one of the following ranges, the biocidal component preferably comprising or consisting of metallic silver and/or metallic copper:
a. in the titanium-based matrix, preferably TiO 2 The biocidal component is present in the matrix at a material fraction of less than 2.0at%,
b. in the titanium-based matrix, preferably TiO 2 The biocidal component is present in the matrix at a material ratio of less than 1.8at%,
c. in the titanium-based matrix, preferably TiO 2 The biocidal component is present in the matrix at a material fraction of less than 1.7at%,
d. in the titanium-based matrix, preferably TiO 2 The substance proportion of the biocidal component in the matrix is in the range between 0.2at% and 2.0at%,
e. in the titanium-based matrix, preferably TiO 2 The mass proportion of the biocidal component in the matrix is in the range between 0.25at% and 1.8at%,
f. In the titanium-based matrix, preferably TiO 2 The material proportion of the biocidal component in the matrix is in the range between 0.3at% and 1.7 at%.
If the anti-reflective coating or the mirror coating comprises at least one additional stack of layers comprising at least one titanium oxide (preferably TiO 2 ) At least one titanium hydroxide, at least one titanium oxide hydrate, at least one titanium nitride, at least one titanium oxynitride and/or at least one titanium sulphide, or a combination thereof, said additional stacked layers constituting an additional titanium-based matrix of the at least one biocidal component deposited on the outermost surface of the outermost stacked layer of the respective coating layer and at least partly diffused into said outermost stacked layer and into the underlying at least one stacked layer. Preferably, the at least one anti-reflective coating or the at least one mirror coating comprises at least one stack layer between the outermost stack layer and the additional stack layer, the stack layer comprising or consisting of another material, preferably at least one metal oxide, at least one metal hydroxide, at least one metal nitride, at least one metal oxynitride, at least one metal oxide hydrate and at least one metal sulfide, each metal comprising or consisting of silicon, aluminum, indium and/or tin. In addition to the titanium-based matrix, preferably TiO 2 The mass proportion of the at least one biocidal component in the matrix is preferably within at least one of the following ranges, the biocidal component preferably comprising or consisting of metallic silver and/or metallic copper:
a. at the additional titanium-based matrix,Preferably additional TiO 2 The biocidal component is present in the matrix at a material ratio of less than 1.5at%,
b. in addition to the titanium-based matrix, preferably TiO 2 The biocidal component is present in the matrix at a material ratio of less than 1.3at%,
c. in addition to the titanium-based matrix, preferably TiO 2 The biocidal component is present in the matrix at a material ratio of less than 1.1at%,
d. in addition to the titanium-based matrix, preferably TiO 2 The mass proportion of the biocidal component in the matrix is in the range between 0.2at% and 1.5at%,
e. in the additional titanium-based matrix, preferably TiO 2 The mass proportion of the biocidal component in the matrix is in the range between 0.25at% and 1.3at%,
f. in the additional titanium-based matrix, preferably TiO 2 The material proportion of the biocidal component in the matrix is in the range between 0.3at% and 1.1 at%.
The values and ranges mentioned above for the material proportion of the at least one biocidal component in the additional titanium-based matrix will also apply to the material proportion of the at least one biocidal component in each of the additional titanium-based matrix of the at least one anti-reflection coating or the additional titanium-based matrix of the at least one mirror coating.
In a preferred embodiment, the ophthalmic lens comprises at least one coating layer (i) and at least two individual metallic silver atoms, preferably a plurality of individual metallic silver atoms, and/or at least two clusters comprising or consisting of metallic silver, preferably a plurality of individual clusters comprising or consisting of metallic silver (ii). The individual atoms and/or clusters are located on top of the outermost surface of the at least one coating layer (i) and, as previously described, at least partially diffuse in the at least one coating layer (i), optionally in at least one coating layer underneath said at least one coating layer (i) and/or in the ophthalmic lens substrate. The total content of metallic silver of the spectacle lens is preferably k=5.10 -4 To 1.10 -4 More preferably k=8·10 -4 To 8.10 -2 And most preferably 1.10 -3 To 5.10 -2 Within the range of (1), in whichAnd ≡ag_s=the integral of metallic silver measured in the spectacle lens and ≡ag_0=the integral of metallic silver measured in a pure silver sheet as a reference. The total content of metallic silver is preferably determined by energy dispersive x-ray spectroscopy (EDX), preferably in the geometric center (±20 mm) from the top of the front and/or rear surface of the ophthalmic lens, preferably by using an EDX-apparatus Oxford Instruments INCA x-ACT and a scanning electron microscope Zeiss Auriga. Ag lα -line was evaluated at a characteristic energy of 2.984 keV. Preferably, the EDX parameters are set as follows:
i. The energy of the electron beam gun is 10kV,
detector energy range: the voltage of the power supply is 0-10kV,
the measurement duration fixed by the lifetime of 300 seconds,
working distance wd=5 mm and
v. the measuring area on the front and/or rear surface of the ophthalmic lens is 0.5mm 2 And 2mm 2 Between them.
Preferably, the value of integral ≡ag_s and the value of integral ≡ag_0 are each obtained as follows:
i. pure silver flakes preferably having a purity of at least 99.9at% are measured using the EDX parameters described above,
the aforementioned EDX parameters are used to make measurements from the top of the front surface of the ophthalmic lens and/or from the top of the rear surface of the ophthalmic lens,
if further evaluation is performed using EDX spectra (count versus energy), it comprises subtracting the linear baseline from the EDX spectra between 2.85keV and 3.1keV, and after the baseline subtraction, integrating the count of EDX spectra between 2.85keV and 3.1keV, resulting in the value of integral ≡ag_0 of metallic silver measured in pure silver flake as reference and the value of integral ≡ag_s of metallic silver measured in an ophthalmic lens.
The ranges mentioned above for K will apply if the ophthalmic lens comprises at least two individual metal silver atoms, preferably a plurality of individual metal silver atoms, and/or at least two clusters comprising or consisting of metal silver, preferably a plurality of individual clusters (ii) comprising or consisting of metal silver, on the front surface of the ophthalmic lens or on the rear surface of the ophthalmic lens. The aforementioned ranges for K will also apply provided that the ophthalmic lens comprises at least two individual metallic silver atoms, preferably a plurality of individual metallic silver atoms, and/or at least two clusters comprising or consisting of metallic silver, preferably a plurality of individual clusters (ii) comprising or consisting of metallic silver, on the front surface of the ophthalmic lens and on the rear surface of the ophthalmic lens. K was evaluated separately for the front and back surfaces.
In a more preferred embodiment, the ophthalmic lens comprises at least one coating layer (i) and at least two individual metallic silver atoms, preferably a plurality of individual metallic silver atoms, and/or at least two clusters comprising or consisting of metallic silver, preferably a plurality of individual clusters comprising or consisting of metallic silver (ii). The individual atoms and/or clusters are located on top of the outermost surface of the at least one coating layer (i) and, as previously described, at least partially diffuse in the at least one coating layer (i), optionally in at least one coating layer underneath said at least one coating layer (i) and/or in the ophthalmic lens substrate. The total content of metallic silver of the ophthalmic lens is preferably in the range from 0.05at% to 0.50at%, more preferably from 0.08at% to 0.45at% and most preferably from 0.10at% to 0.40 at%. The total content of metallic silver is preferably determined by EDX mapping of thin layers of approximately 50nm thickness of a cross section of one surface of the ophthalmic lens, preferably obtained via a Focused Ion Beam (FIB). "about" 50nm thick preferably means a thin layer thickness of 50nm + -20 nm cross-section. The thin layer preferably comprises at least one coating (i) and at least two individual metallic silver atoms, preferably a plurality of individual metallic silver atoms, and/or at least two clusters comprising or consisting of metallic silver, preferably a plurality of individual clusters (ii) comprising or consisting of metallic silver deposited on top of said coating (i). For EDX mapping of all elements of the thin layers of the cross section, an S-TEM/EDX device (EDX-device Oxford Instruments INCA x-ACT, S-TEM Hitachi HF 5000) is preferably used. For the determination of the total content of metallic silver, the L-alpha series with a main peak at 2.984keV was used. EDX mapping of all elements of the thin layers of cross section is preferably performed in the designated destination area, the total destination area is integrated, and the total content of metallic silver is calculated. The designated area of interest comprises the at least one coating (i) and individual metallic silver atoms and/or individual metallic silver clusters (ii) located on top of the outermost surface of the at least one coating (i). If the at least one coating (i) is a hard coating or a photochromic coating, the region of interest preferably comprises a corresponding coating of 400nm perpendicular to the surface of the ophthalmic lens. If the at least one coating (i) is an anti-reflective coating or a mirror coating, the region of interest preferably comprises all stacked layers of the respective coating. The ranges mentioned above for the total content of metallic silver apply to all of the aforementioned target areas of the front or rear surface of the ophthalmic lens.
If the ophthalmic lens comprises at least one coating (i) and at least two individual metallic copper atoms, preferably a plurality of individual metallic copper atoms, and/or at least two clusters comprising or consisting of metallic copper, preferably a plurality of individual clusters (ii) comprising or consisting of metallic copper, the total content of metallic copper is similarly determined, preferably by evaluating the kα series of the main line at 8.046 keV.
An additional or alternative second embodiment of the above first embodiment is an ophthalmic lens comprising an ophthalmic lens substrate preferably comprising i.glass or ii.at least one glass, preferably at least one thin glass, and at least one thermoplastic hard resin and/or at least one thermosetting hard resin, and
(i) At least one coating comprising or consisting of at least one anti-reflective coating and/or at least one specular coating, each coating comprising or consisting of at least two stacked layers,
(ii) At least two individual atoms comprising or consisting of metallic silver and/or at least two individual clusters comprising or consisting of metallic silver, each of the at least two individual atoms and/or the at least two individual clusters being at least partially located on top of the outermost surface of the at least one coating layer (i), and
(iii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating, and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens.
In this second embodiment, the at least one coating (i) (preferably one coating (i)) applied to or deposited on the uncoated or pre-coated front surface of the ophthalmic lens substrate may be of the same type or of a different type than the at least one coating (i) (preferably one coating (i)) applied to or deposited on the uncoated or pre-coated rear surface of the ophthalmic lens substrate. The same type means that both the uncoated or pre-coated front surface and the uncoated or pre-coated back surface of the ophthalmic lens substrate comprise an anti-reflective coating or a specular coating. By different types is meant that one of the uncoated or pre-coated surfaces comprises an anti-reflective coating and the other comprises a specular coating. Preferably, in this second embodiment, the at least one coating layer (i) (preferably one coating layer (i)) comprises or consists of an anti-reflective coating layer comprising, starting from an uncoated or pre-coated surface of the ophthalmic lens substrate to be coated therewith, at least:
a)0.74131·λ 0 4.M to 0.89369.lambda. 0 /4·M；0.34275·λ 0 4-L to 0.41206-lambda 0 /4·L；0.54089·λ 0 4.M to 0.65207.lambda. 0 /4·M；0.70021·λ 0 4-L to 0.84181-lambda 0 /4·L；0.65779·λ 0 4.M to 0.79301.lambda. 0 /4·M；0.12950·λ 0 4.H to 0.16235.lambda 0 /4·H；0.49624·λ 0 4.M to 0.59825.lambda. 0 /4·M；0.28033·λ 0 4.H to 0.35143.lambda 0 /4·H；1.03563·λ 0 4-L to 1.24528-lambda 0 4.L; or (b)
b)0.64253·λ 0 4.M to 0.77461.lambda. 0 /4·M；0.29675·λ 0 4-L to 0.35676-lambda 0 /4·L；0.27260·λ 0 4.M to 0.32864 ]λ 0 /4·M；0.75891·λ 0 4-L to 0.91237-lambda 0 /4·L；0.90476·λ 0 4.M to 1.09075.lambda. 0 /4·M；0.10051·λ 0 4.H to 0.12600.lambda 0 /4·H；0.37747·λ 0 4.M to 0.45506.lambda. 0 /4·M；0.80453·λ 0 4-L to 0.96739-lambda 0 4.L; or (b)
c)0.19459·λ 0 4-L to 0.23394-lambda 0 /4·L；0.60931·λ 0 4.M to 0.73457.lambda. 0 /4·M；0.51278·λ 0 4-L to 0.61648-lambda 0 /4·L；0.45267·λ 0 4.M to 0.54573.lambda. 0 /4·M；0.48976·λ 0 4-L to 0.58880-lambda 0 /4·L；0.64177·λ 0 4.M to 0.77369.lambda. 0 /4·M；0.18388·λ 0 4.H to 0.23052.lambda 0 /4·H；0.50401·λ 0 4.M to 0.60762.lambda. 0 /4·M；0.31035·λ 0 4.H to 0.38910.lambda 0 /4·H；1.03965·λ 0 4-L to 1.25011-lambda 0 /4·L；
Wherein in each of the aforementioned layer sequences lambda 0 Preferably selected from any wavelength in the range from 500nm to 600nm, the refractive index of M, L, H is preferably wavelength dependent, M preferably has a wavelength dependent refractive index in the range from 1.632 at 380nm to 1.599 at 780nm, preferably has a wavelength dependent refractive index of 1.614 at 500nm to 1.606 at 600nm, L preferably has a wavelength dependent refractive index in the range from 1.473 at 380nm to 1.456 at 780nm, preferably has a wavelength dependent refractive index of 1.462 at 500nm and 1.459 at 600nm, H preferably has a wavelength dependent refractive index in the range from 2.832 at 380nm to 2.270 at 780nm, preferably has a wavelength dependent refractive index of 2.440 at 500nm and 2.336 at 600 nm. Preferably M is Al x O y Wherein x is 1.5 to 2.5, preferably 2, and y is 2.5 to 3.5, preferably 3; l is SiO z Wherein z is 1.5 to 2.5, preferably 2; h is Ti a O b Wherein a is 0.5 to 1.5, preferably 1, and b is 1.5 to 2.5, preferably 2; or Nb (Nb) c O d Wherein c is 1.5 to 2.5, preferably 2, and d is 4.5 to 5.5, preferably 5. Can be used forAlternatively, layer M preferably has a wavelength dependent refractive index ranging from 1.750 at 380nm to 1.701 at 780nm, preferably from 1.724 at 500nm to 1.712 at 600 nm. In this alternative, M comprises Pr e O f Or by Pr e O f A composition wherein e is 1.0 to 6 and f is 2.0 to 11, preferably e is 6 and f is 11, or layer M comprises Al x O y And Pr (Pr) e O f Or a mixed oxide of Al and Pr or a mixture of Al x O y And Pr (Pr) e O f Or a mixed oxide of Al and Pr. Commercially available products comprising oxides of Al and Pr are, for example, paso I, paso II and Paso III, all from the grace company. In each anti-reflective coating comprising at least two M layers and/or at least two H layers, the respective M layers or H layers may comprise or consist of the same composition or different compositions.
As previously described, at least partial diffusion of metallic silver applied to or deposited on the outermost surface of the outermost stacked layer (i.e., the stacked layer furthest from the uncoated or pre-coated surface of the ophthalmic lens substrate comprising the anti-reflective coating or the mirror coating) at least in the respective outermost stacked layer and in any stacked layer below said respective outermost stacked layer results in at least two individual metallic silver atoms, preferably a plurality of individual atoms, and/or at least two individual metallic silver clusters, preferably a plurality of individual clusters, being distributed over the anti-reflective coating or the mirror coating. The total content of metallic silver in the anti-reflective coating or mirror is preferably determined via EDX mapping as described previously, preferably in the range from 0.05at% to 0.50at%, more preferably from 0.08at% to 0.45at% and most preferably from 0.10at% to 0.40 at%.
For the maximum size of individual clusters, refer to the comments previously described.
Preferably, the at least two individual metallic silver atoms, preferably a plurality of individual atoms, and/or the at least two individual metallic silver clusters (ii), preferably a plurality of individual clusters, preferably form a discontinuous layer or island film on top of the outermost surface of the anti-reflective coating or mirror coating. The discontinuous layer or island film preferably has a nominal layer thickness of less than 12nm, more preferably less than 10nm, more preferably less than 8nm, and most preferably less than 6nm. The transmission characteristics and the antimicrobial and/or antiviral characteristics are so adjusted to meet the needs of the ophthalmic lens wearer for transparency and health-related antiviral and/or antibacterial effects.
Another additional or alternative third embodiment is directed to an ophthalmic lens comprising an ophthalmic lens substrate and
(i) At least one of the layers of the coating,
(ii) At least two individual atoms comprising or consisting of metallic silver and/or at least two individual clusters comprising or consisting of metallic silver, each of the at least two individual atoms and/or the at least two individual clusters being at least partially located on top of the outermost surface of the at least one coating layer (i), and
(iii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating, and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens.
In this third embodiment, the at least one coating (i) is preferably at least one coating selected from the group consisting of: at least one layer, preferably one layer, comprising or consisting of: at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydroxide, at least one metal sulfide, at least one metal nitride, and/or at least one metal oxynitride (each of silicon); at least one primer coating, preferably one primer coating, and at least one hard coating, preferably one hard coating. Each of the one layer or the primer coating or the hard coating constitutes a matrix of metallic silver that diffuses at least partially into the respective layer or coating, as previously described.
According to the invention, at least one other coating is applied in at least the one layer or at least the one primer coating or in the one hard coating and, as the case may be, underneath or above itThe metallic silver in the layer, and/or in the ophthalmic lens substrate together have a metallic silver content that causes the photochromic effect of the ophthalmic lens. The metallic silver content is set such that section 7.5.3.2 of the ophthalmic lens according to ISO 8980-3:2013 (E) caused by the photochromic effect has a light transmittance (τ) in the faded state V0 ) Transmittance (τ) of an ophthalmic lens in darkened state with section 7.5.3.3 according to ISO 8980-3:2013 (E) V1 ) The variation between is within the following group:
(A)τ V1 /τ V0 ≤0.95，
(B)τ V1 /τ V0 ≤0.98，
(C)0.95≤τ V1 /τ V0 ≤0.995，
(D)0.98≤τ V1 /τ V0 ≤0.995，
(E)0.985≤τ V1 /τ V0 ≤0.995。
the inventors have found that such adjustments include adjusting the transmission characteristics as well as the antimicrobial and/or antiviral characteristics so as to meet the needs of the ophthalmic lens wearer for increased/sufficient transparency and increased/sufficient health-related antiviral and/or antibacterial effects.
In a preferred but optional further embodiment, the light transmittance in the faded state τ as defined in section 7.5.3.2 of ISO 8980-3:2013 (E) V0 Values exceeding 95%, preferably 96%, most preferably 97%.
Yet another fourth additional or alternative embodiment is directed to an ophthalmic lens comprising an ophthalmic lens substrate preferably comprising at least one thermosetting resin and/or at least one thermoplastic resin, and
(i) At least one coating, preferably selected from the group consisting of at least one anti-reflective coating, preferably one anti-reflective coating, and at least one specular coating, preferably one specular coating,
(ii) At least two separate atoms of at least one biocidal component and/or at least two separate molecules of at least one biocidal component and/or at least two separate clusters of at least one biocidal component, each of which at least two separate atoms and/or at least two separate molecules and/or at least two separate clusters is/are located at least partially on top of the outermost surface of the at least one coating layer (i), preferably the at least one biocidal component comprises at least one component selected from the group consisting of at least one metal, at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal nitride and/or at least one metal oxynitride and at least one metal sulfide, each component comprising or consisting of at least one metal selected from the group consisting of silver, copper, titanium, zinc and iron, and
(iii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating, and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens.
Preferably, the at least one biocidal component comprises at least one component selected from the group consisting of at least one metal, at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal nitride and/or at least one metal oxynitride and at least one metal sulfide, each metal comprising or consisting of silver or copper.
The anti-reflection coating or the mirror coating each preferably comprises a stack of at least two stacked layers. The stack includes an outermost stack layer. At least the outermost stacked layer comprises at least in part at least one biocidal component that is applied to or deposited on the outermost surface of the outermost stacked layer due to diffusion of the at least one biocidal component as previously described. The outermost surface faces away from the ophthalmic lens surface. Due to the diffusion as described before, the at least one biocidal component is preferably distributed at least in the entire stack of the anti-reflective coating or the mirror coating in the form of at least two individual atoms, preferably a plurality of individual atoms and/or at least two individual molecules, preferably a plurality of individual molecules and/or at least two individual clusters, preferably a plurality of individual clusters.
According to the invention, the anti-reflection coating or the mirror coating is each designed to have a diffusivity (D F ) The diffusivity is configured to ensure absorption of water molecules passing through the anti-reflective coating or the specular coating into the ophthalmic lens substrate and release of water molecules from the ophthalmic lens substrate through the anti-reflective coating or the specular coating from an air atmosphere present on the outermost surface of the outermost stacked layers. The air atmosphere provides a water split density (j) D ). Said diffusivity (D F ) Is further configured to set a second equilibrium state of the amount of water molecules absorbed by the ophthalmic lens substrate in an air atmosphere of 40 degrees celsius and 95% relative humidity over a first time interval starting from the first equilibrium state of the amount of water molecules absorbed by the ophthalmic lens substrate in an air atmosphere of 23 degrees celsius and 50% relative humidity. The first time interval is at most ten hours longer than a second time interval required to set the second equilibrium state from the first equilibrium state in an uncoated ophthalmic lens substrate identical to the ophthalmic lens substrate. Guidelines for producing coatings with such water molecule diffusivity properties are disclosed, for example, in EP 2 801 846 A1 or EP 3 740 815 A1.
Providing such diffusivity properties at least for an anti-reflective coating or a specular coating of an ophthalmic lens preferably designated to provide an antiviral and/or antibacterial effect enables water to enter the respective coating and leave the respective coating together with dissolved ions of the at least one biocidal component, which in turn is a prerequisite for the antiviral and/or antibacterial efficacy of the ophthalmic lens.
Yet another fifth additional or alternative embodiment is directed to an ophthalmic lens comprising an ophthalmic lens substrate and
(i) At least one of the layers of the coating,
(ii) At least two individual atoms of at least one biocidal component and/or at least two individual molecules of at least one biocidal component and/or at least two individual clusters of at least one biocidal component, each at least partially located on top of the outermost surface of the at least one coating (i), and
(iii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating, and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens.
In this fifth embodiment, the at least one coating (i) comprises at least one coating selected from the group consisting of: at least one layer, preferably one layer, comprising or consisting of: at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydroxide, at least one metal sulfide, at least one metal nitride, and/or at least one metal oxynitride (each of silicon); at least one photochromic primer coating, preferably one photochromic primer coating; at least one photochromic coating, preferably one photochromic coating; at least one primer coating, preferably one primer coating; at least one hard coat layer, preferably one hard coat layer; at least one anti-reflective coating, preferably one anti-reflective coating; and at least one mirror coating, preferably one mirror coating. Preferably, the at least one coating (i) comprises at least one coating selected from the group consisting of the at least one layer, preferably the one layer and the at least one hard coating, preferably one hard coating. The layer thickness of the at least one layer is preferably in the range from 10nm to 300nm, further preferably from 20nm to 270nm, further preferably from 30nm to 250nm, more preferably from 40nm to 230nm and most preferably from 50nm to 210 nm.
Further, in this fifth embodiment, the at least one biocidal component preferably comprises or consists of at least one component selected from the group consisting of at least one metal, at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal nitride and/or at least one metal oxynitride and at least one metal sulfide, each component comprising or consisting of at least one metal selected from the group consisting of silver, copper, titanium, zinc and iron. Preferably, the at least one metal is selected from the group consisting of silver, titanium and zinc, more preferably the group consisting of silver and titanium, and most preferably silver. The at least one biocidal component is applied or deposited as described above on the outermost surface of the at least one coating layer (i), preferably on the outermost surface of the one layer or the one hard coating layer.
The at least one coating (i) is preferably applied to the uncoated or pre-coated front surface of the ophthalmic lens substrate and/or to the uncoated or pre-coated rear surface of the ophthalmic lens substrate, preferably at least to the uncoated or pre-coated front surface of the ophthalmic lens substrate. The at least one coating (i) applied to the uncoated or pre-coated front surface of the ophthalmic lens substrate may be of the same type or of a different type than the at least one coating (i) applied to the uncoated or pre-coated rear surface of the ophthalmic lens substrate. For example, the one layer may be applied to an uncoated or pre-coated front surface of the ophthalmic lens substrate and the hard coating may be applied to an uncoated or pre-coated rear surface of the ophthalmic lens substrate. The layer thickness and/or composition of at least the at least one coating layer may be the same or different provided that the same type of the at least one coating layer (i) may be applied onto the uncoated or pre-coated front surface of the ophthalmic lens substrate and onto the uncoated or pre-coated rear surface of the ophthalmic lens substrate, preferably the one layer or the hard coating layer. Furthermore, the type of the at least one biocidal component applied or deposited on the outermost surface of the at least one coating (i) may be the same or different when applied or deposited on the outermost surface of the at least one coating (i) present on the uncoated or pre-coated front surface of the ophthalmic lens substrate or on the uncoated or pre-coated rear surface thereof.
As the at least one biocidal component at least partially diffuses at least into the one layer or the one coating (on the outermost surface of which the at least one biocidal component has been applied or deposited), at least the one layer or the one coating each constitute a matrix comprising the at least one biocidal component.
According to the invention, the at least one biocidal component in at least the outermost one of the layers or in at least the outermost one of the coating layers each has a content such that when the metal ions of the respective at least one biocidal component are released from the ophthalmic lens by exposing the ophthalmic lens to 10ml of deionized water at 23 ℃ for six hours, the concentration of the metal ions dissolved in the deionized water is measured to be at least 0.05mg/l, preferably at least 0.07mg/l, most preferably at least 0.09mg/l.
Providing that the at least one coating (i) comprises at least one matrix comprising or consisting of the following layers constituting the at least one biocidal component: at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydroxide, at least one metal sulfide, at least one metal nitride and/or at least one metal oxynitride (each of which is silicon), then preferably at least one metal of the at least one biocidal component may be arranged interstitially in the matrix. This interstitial arrangement provides the ability to dissolve in water, as opposed to chemical bonds or bonding in a lattice structure, which constitutes a prerequisite for antiviral and/or antibacterial activity.
In case the at least one coating (i) with the at least one biocidal component applied or deposited on top of it and/or in said above-mentioned overall coating of said ophthalmic lens is provided, for example, preferably such dissolution characteristics in combination with said substance ratio of the at least one biocidal component and/or said individual cluster formation, said ophthalmic lens is adapted to provide said antiviral and/or antibacterial effect. In particular, the above-described ophthalmic lens properties allow water to enter the layer or the coating and leave the layer or the coating together with dissolved metal ions, which is a prerequisite for antiviral and/or antibacterial efficacy.
An alternative or additional sixth embodiment of the invention is directed to an ophthalmic lens comprising an ophthalmic lens substrate and
(i) At least one coating (i) comprising or consisting of: at least one layer, preferably one layer, comprising at leastSilicon oxide, at least one silicon hydroxide oxide, at least one silicon sulfide, at least one silicon nitride and/or at least one silicon oxynitride or a combination thereof, further preferably a layer comprising silicon oxide, preferably SiO 2 Or consists thereof, further preferably the one layer has a layer thickness in the range from 10nm to 300nm, further preferably from 20nm to 270nm, further preferably from 30nm to 250nm, more preferably from 40nm to 230nm and most preferably from 50nm to 210nm,
(ii) At least two individual metallic silver and/or metallic copper atoms, preferably a plurality of individual metallic silver or metallic copper atoms, and/or at least two individual metallic silver or metallic copper clusters, preferably a plurality of individual metallic silver or metallic copper clusters, preferably the at least two individual atoms and/or the at least two individual clusters are at least partially located on top of the outermost surface of the at least one coating (i),
(iii) Optionally at least one coating selected from the group consisting of at least one cleaning coating and at least one anti-fog coating, preferably the at least one coating is the outermost coating of an ophthalmic lens.
The at least one coating (i) may be applied to at least one uncoated or pre-coated surface of the ophthalmic lens substrate. Preferably, at least the front surface of the ophthalmic lens substrate comprises the at least one coating (i) and the at least two separate metallic silver and/or metallic copper atoms and/or the at least two separate metallic silver or metallic copper clusters (ii) so as to prevent the eyes of the wearer of the ophthalmic lens from being affected by bacteria and/or viruses exhaled by the person opposite the wearer of the ophthalmic lens. The rear surface of the ophthalmic lens substrate may comprise the same coating or a coating according to one of the previous embodiments or a different coating as previously described.
The partial diffusion of metallic silver applied to or deposited on the outermost surface of the at least one layer, preferably one layer (i.e. the layer furthest from the uncoated or pre-coated surface of the ophthalmic lens substrate comprising the at least one layer), preferably results in a material proportion of said metallic silver and/or said metal in at least said one layer within at least one of the following ranges, namely: the mass proportion of the metallic silver and/or the metallic copper in the one layer is less than 3.5at%, or less than 3.0at%, or even less than 2.5at%. Preferably, there is also a lower limit for the metallic silver and/or metallic copper content: thus, the mass proportion of the metallic silver (Ag) in the one layer is preferably in the range between 0.8at% and 3.5at%, more preferably between 0.9at% and 2.5at%, and most preferably between 1.0at% and 2.5at%.
The mass ratio is preferably defined as the number of silver atoms and/or copper atoms divided by the total number of atoms in the one layer. The determination of the material proportion is preferably based on rutherford backscattering spectrometry. The material proportion is preferably determined within a period of 72 hours, preferably 48 hours, after the metallic silver and/or metallic copper has been applied or deposited on the outermost surface of the one layer. After this period of time, the mass proportion of the metallic silver and/or the metallic copper may deviate slightly from the above range. The slight deviation, which is assumed to be due to further diffusion of the metallic silver and/or metallic copper into the at least one coating layer underneath the one layer and/or into the ophthalmic lens substrate, is preferably within ±20%, further preferably within ±10%, each relative to the mass proportion determined 24 hours after the metallic silver and/or metallic copper has been applied or deposited on the outermost surface of the one layer.
An additional or alternative seventh embodiment comprises an ophthalmic lens comprising an uncoated ophthalmic lens substrate and
(i) At least two individual atoms, preferably a plurality of individual atoms, of the at least one biocidal component, and/or at least two individual molecules, preferably a plurality of individual molecules, of the at least one biocidal component, and/or at least two individual clusters, preferably a plurality of individual clusters,
(ii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating and at least one anti-fog coating, preferably at least one cleaning coating and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens.
Preferably, the at least one biocidal component comprises or consists of at least one of the biocidal components mentioned in any of the previous embodiments. Further preferably, the at least one biocidal component comprises or consists of metallic silver and/or metallic copper.
At least one of the uncoated front surface and the uncoated rear surface of the ophthalmic lens substrate comprises at least two individual atoms of the at least one biocidal component and/or at least two individual clusters of the at least one biocidal component, the nominal layer thickness being preferably less than 12nm, further preferably less than 10nm, further preferably less than 9nm, more preferably less than 7nm and most preferably less than 6nm. The nominal layer thickness includes the layer thickness as described above and is determined as described above.
The at least two individual atoms and/or at least two individual clusters of the at least one biocidal component preferably form an island-like film or discontinuous layer on the surface of the ophthalmic lens substrate on which the at least one biocidal component has been applied or has been deposited. If the at least one biocidal component is at least partially diffused into the ophthalmic lens substrate, the at least one biocidal component is present within the ophthalmic lens substrate in the form of at least two individual atoms of the at least one biocidal component, preferably a plurality of individual atoms of the at least one biocidal component, and/or at least two individual molecules of the at least one biocidal component, preferably a plurality of individual molecules of the at least one biocidal component, and/or at least two individual clusters of the at least one biocidal component, preferably a plurality of individual clusters of the at least one biocidal component. The individual clusters on top of and within the ophthalmic lens substrate preferably have a maximum spread within at least one of the following ranges:
(i) The individual clusters have a maximum spread of less than 20nm,
(ii) The individual clusters have a maximum spread of less than 15nm,
(iii) The individual clusters have a maximum spread of less than 10nm,
(iv) The individual clusters have a maximum spread in the range of 1nm to 20nm,
(v) The individual clusters have a maximum spread in the range of 1nm to 15nm,
(vi) The individual clusters have a maximum spread in the range of 1nm to 10nm,
(vii) The individual clusters have a maximum spread in the range of 0.5nm to 20nm,
(viii) The individual clusters have a maximum spread in the range of 0.5nm to 15nm,
(ix) The individual clusters have a maximum spread in the range of 0.5nm to 10 nm.
The maximum extension of each of the at least two individual clusters may be the same or different, preferably having one of the aforementioned values or in any of the aforementioned ranges.
Another preferred embodiment of the invention (and also applicable to all of the foregoing embodiments) is characterized in that: the content of the at least one biocidal component in the ophthalmic lens is optionally set to kill more than or equal to 95%, preferably more than or equal to 99.9% of enveloped viruses as measured according to ISO 21702:2019 (E).
Another preferred embodiment of the invention (and also applicable to all of the foregoing embodiments) is characterized in that: the content of the at least one biocidal component in the ophthalmic lens is optionally set to kill more than or equal to 95%, preferably more than or equal to 99.9% of bacteria as measured according to ISO 22196:2011 (E).
A first embodiment of the invention is directed to a method for manufacturing an ophthalmic lens comprising an ophthalmic lens substrate and
(i) At least one of the layers of the coating,
(ii) At least two individual atoms, preferably a plurality of individual atoms, of the at least one biocidal component, and/or at least two individual molecules, preferably a plurality of individual molecules, of the at least one biocidal component, and/or at least two individual clusters, preferably a plurality of individual clusters, of the at least one biocidal component, preferably the at least two individual atoms and/or the at least two individual molecules and/or the at least two individual clusters being located on top of the outermost surface of the at least one coating (i), and
(iii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens,
the method at least comprises the following steps:
applying or depositing the at least one coating (i) onto at least one uncoated or pre-coated surface of the ophthalmic lens substrate, preferably onto at least the uncoated or pre-coated front surface of the ophthalmic lens substrate,
-depositing at least one biocidal component onto the outermost surface of the at least one coating layer (i), preferably by evaporation, optionally by evaporation with the aid of an ion beam, further preferably at a nominal layer thickness of less than 12nm, further preferably less than 10nm, more preferably less than 8nm and most preferably less than 6nm, the deposited at least one biocidal component forming at least one island-like or discontinuous layer (ii') comprising or consisting of the at least one biocidal component, and optionally
-applying the at least one coating (iii) to the outermost surface of the at least one coating (i) and/or to the outermost surface of the at least one discontinuous layer (ii').
The individual steps according to the method described above are consecutive steps. Preferably, the at least one coating (i) is applied to the uncoated or pre-coated front surface and/or the uncoated or pre-coated rear surface of the ophthalmic lens substrate, followed by the deposition of the at least one biocidal component (ii) on the outermost surface of the at least one coating (i). Optionally, the at least one coating (iii) is subsequently applied. If the at least one biocidal component forms the at least one island-like or discontinuous layer (ii '), the adhesion between the at least one coating (iii) and the at least one coating (i) corresponds at least to the adhesion between the same at least one coating (iii) and the same at least one coating (i) without the at least one discontinuous layer (ii'). Of particular note, the at least one island or discontinuous layer (ii ') allows the use of established coatings as at least one coating (i) and as at least one coating (iii), preferably while maintaining or only slightly deviating from the optical properties, such as light reflectivity and/or spectral reflectivity, and/or mechanical properties, such as scratch resistance, of an ophthalmic lens comprising only the same at least one coating (i) and the same at least one coating (iii) (i.e. without the at least one island or discontinuous layer (ii '), preferably in addition to the contribution of the at least one island or discontinuous layer (ii ') to the antimicrobial and/or antiviral efficacy of the ophthalmic lens.
Preferably, the deposition of the at least one biocidal component forming the at least one island or discontinuous layer (ii') does not require a change in the established coating sequence applicable to at least one of the uncoated or pre-coated surfaces of the ophthalmic lens substrate.
The at least one coating (i) preferably comprises at least one coating selected from the group consisting of: at least one layer comprising or consisting of: at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal sulfide, at least one metal nitride and/or at least one metal oxynitride (each of silicon); at least one photochromic primer coating; at least one photochromic coating; at least one primer coating; at least one hard coat layer; at least one anti-reflective coating; and at least one specular coating. Preferably, the at least one coating (i) comprises at least one coating selected from the group consisting of: at least one layer comprising or consisting of: at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal sulfide, at least one metal nitride and/or at least one metal oxynitride (each of silicon); a photochromic primer coating; a photochromic coating; a primer coating; a hard coat layer; an anti-reflective coating; and a mirror coating. Further preferably, the at least one coating (i) comprises at least one coating selected from the group consisting of: a hard coating, an anti-reflective coating and a mirror coating, more preferably a hard coating and an anti-reflective coating; or a hard coat and a mirror coat. The aforementioned at least one layer comprises or consists of: the layer thickness of the aforementioned at least one layer is preferably in the range from 10nm to 300nm, further preferably from 20nm to 270nm, further preferably from 30nm to 250nm, more preferably from 40nm to 230nm and most preferably from 50nm to 210nm, at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal nitride and/or at least one metal oxynitride (each being silicon).
The at least one coating (i) applied to the uncoated or pre-coated front surface of the ophthalmic lens substrate may be the same or different than the at least one coating (i) applied to the uncoated or pre-coated back surface of the ophthalmic lens substrate. For example, the uncoated or pre-coated front surface of the ophthalmic lens substrate may comprise as coating (i) an antireflective coating, preferably the coating furthest from the front surface of the ophthalmic lens substrate prior to depositing the at least one biocidal component, and the uncoated or pre-coated rear surface of the ophthalmic lens substrate may comprise as coating (i) a hard coating, preferably the coating furthest from the rear surface of the ophthalmic lens substrate prior to depositing the at least one biocidal component. Furthermore, the uncoated or pre-coated front surface and the uncoated or pre-coated back surface of the ophthalmic lens substrate may comprise the same type of coating (i), preferably a hard coating or an anti-reflective coating or a mirror coating, but the chemical composition and/or the layer thickness and/or, where applicable, the order of the stacked layers is different.
Preferably, the at least one coating layer (i) is the outermost coating layer of the uncoated or pre-coated surface of the ophthalmic lens substrate comprising the at least one coating layer (i) before depositing the at least one biocidal component on the outermost surface of the at least one coating layer (i).
The at least one biocidal component is deposited on the outermost surface of the at least one coating (i), and preferably a discontinuous layer (ii) is formed during the deposition of said biocidal component. The at least one biocidal component preferably comprises or consists of at least one component selected from the group consisting of at least one metal, at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal nitride, at least one metal oxynitride and at least one metal sulfide, each component comprising or consisting of at least one metal selected from the group consisting of silver, copper, titanium, zinc and iron. Preferably, each component comprises or consists of at least one metal selected from the group consisting of silver, copper, zinc and iron, further preferably the group consisting of silver, copper and zinc, and more preferably the group consisting of silver and zinc. Most preferably, the at least one metal of each component comprises or consists of silver. The at least one biocidal component is preferably deposited on the outermost surface of the at least one coating layer (i) with a nominal layer thickness in the range from 0.3nm to 12nm, further preferably from 0.5nm to 10nm, more preferably from 0.7nm to 8nm and most preferably from 0.9nm to 6 nm. The term nominal layer thickness refers to the layer thickness of the at least one biocidal component that should be deposited as a closed or continuous layer on the outermost surface of the at least one coating layer (i) but spontaneously recombine itself into an island film or discontinuous layer (ii'). During deposition of the at least one biocidal component, spontaneous recombination of at least one continuous layer of the deposited at least one biocidal component into the resulting at least one island-like film or discontinuous layer (ii') occurs. Alternatively, the at least island film or discontinuous layer (ii') is formed on the outermost surface of the at least one coating layer (i) during deposition of the at least one biocidal component, rather than forming a closed or continuous layer. If the deposited at least one biocidal component forms and retains at least one discontinuous layer (ii'), its nominal layer thickness preferably refers to the layer thickness measured with the corresponding closed or continuous layer formed and retained. An indirect possibility to measure the nominal thickness of the at least one discontinuous layer (ii) is preferably to use a quartz crystal microbalance during deposition. An alternative, direct possibility to measure the nominal layer thickness of the at least one discontinuous layer (ii') is preferably to deposit the at least one biocidal component on the surface of the substrate, which at least one biocidal component forms and retains a closed or continuous layer on the surface of the substrate and does not spontaneously recombine itself into an island-like film or discontinuous layer. Preferably, the at least one biocidal component does not diffuse into the surface of the substrate. The corresponding layer thickness is then preferably measured by preparing a section of the substrate comprising preferably at least the closed or continuous layer and recording the scaled pictures with a scanning electron microscope, preferably a scanning electron microscope of the Zeiss aurega series of the company carl Zeiss (Carl Zeiss Microscopy GmbH).
Preferably, the at least one biocidal component comprises or consists of metallic silver, which when deposited on the outermost surface of the at least one coating (i) preferably produces an island-like film or discontinuous layer with a nominal layer thickness preferably in the range from 0.2nm to 12nm, further preferably from 0.4nm to 10nm, more preferably from 0.6nm to 9nm, more preferably from 0.7nm to 7nm and most preferably from 0.8nm to 6 nm.
Preferably, the at least one biocidal component is deposited on the outermost surface of the at least one coating layer by evaporation. The evaporation may be electron beam evaporation or thermal evaporation, preferably electron beam evaporation, further preferably electron beam evaporation with the aid of an ion beam. Preferably, at least one ion source for ion beam assist or for the following mentioned post-treatment with at least one ion beam has the following characteristics: the type of ion source is of the End-Hall type, such as Mark ii+ from the company Veeco, new york 11803, planeview, usa. These ions are preferably oxygen ions and/or argon ions, each typically 2 to 6x 10 -4 The energy under vacuum conditions of millibar is between 80eV and 100 eV. Under these conditions, the ion flux density at the ophthalmic lens substrate location is in the range of 30 to 50. Mu.A/cm 2 Between them. In ion sources of the type described, the ion beam is neutralized by electron emission. Molecular oxygen is optionally added to the vacuum chamber in addition to oxygen and/or argon ions leaving the ion source.
Preferably, the at least one biocidal component at least partially diffuses at least into the at least one coating (i) below, i.e. at least into the at least one coating (i) on the outermost surface of which the at least one biocidal component has been deposited. At least partial diffusion into the at least one coating (i) may occur over time. Additionally or alternatively, at least partial diffusion into the at least one coating (i) may be accelerated by ion beam assisted deposition of the at least one biocidal component optionally at a higher temperature as is usual for corresponding deposition, or may be accelerated by post-treatment of an ophthalmic lens comprising the at least one coating (i) and the at least one discontinuous layer (ii'). Post-treatment of the ophthalmic lens may include, for example, exposure to moisture and/or at least one treatment with at least one ion beam. If only one of the uncoated or pre-coated surfaces of the ophthalmic lens substrate has the at least one discontinuous layer (ii'), it goes without saying that the aforementioned acceleration or post-treatment is preferably applied to the corresponding surface on which the at least one biocidal component has been deposited. Furthermore, the at least one biocidal component may not only partially diffuse into the at least one coating (i) but also into at least one coating underlying the at least one coating (i). The at least one coating layer below the at least one coating layer (i) is meant herein to be a coating layer closer to the uncoated or pre-coated surface of the ophthalmic lens substrate comprising the at least one coating layer below and the at least one coating layer (i). The underlying at least one coating may be any coating between the uncoated or pre-coated surface of the ophthalmic lens substrate and the at least one coating (i). In case the coating comprises at least two stacked layers, such as for example an anti-reflective coating or a mirror coating, at least partly diffusing into the at least one coating (i) preferably comprises at least partly diffusing into the outermost stacked layer of the respective coating. Thus, the underlying at least one coating layer also comprises at least one of said anti-reflective coating layer or a stack of said mirror coating layers closer to the uncoated or pre-coated surface of the ophthalmic lens substrate. Depending on at least the composition of each of the coatings or each of the stacked layers, respectively, the proportion of the substance of the at least one biocidal component in each of the coatings or each of the stacked layers may vary and thus does not necessarily result in a continuously decreasing proportion of the substance of the at least one biocidal component in the coating and/or stacked layers closer to the ophthalmic lens substrate. Furthermore, the at least one biocidal component may at least partially diffuse into the ophthalmic lens substrate and optionally into a coating applied to the respective opposite surface of the ophthalmic lens through the ophthalmic lens substrate. Thus, even if the at least one biocidal component has been deposited only on the at least one coating (i) of the uncoated or pre-coated front surface of the ophthalmic lens substrate, the at least one biocidal component can be seen in the coating of the ophthalmic lens substrate and the rear surface of the ophthalmic lens substrate, and vice versa. If the ophthalmic lens comprises at least one coating (iii), the at least one biocidal component may preferably additionally at least partially diffuse into said coating (iii).
In summary, the method optionally comprises the following additional steps after depositing the at least one biocidal component:
-then treating the deposited at least one biocidal component with at least one ion beam.
Preferably, at least partial diffusion of the at least one biocidal component deposited on the outermost surface of the at least one coating layer (i) results in a mass proportion of the biocidal component in the coating layer (i) of less than 3.5at%, further preferably less than 3.0at%, and more preferably less than 2.5at%, each based on the total number of atoms in the coating layer (i). It has been found that the transmission properties as well as the antibacterial and/or antiviral properties of the ophthalmic lens are most suitable in order to meet the needs of the wearer of the ophthalmic lens, provided that the substance proportion of the at least one biocidal component in the at least one coating (i) is in the range between 0.8at% and 3.5at%, or in the range between 0.9at% and 3.0at%, or in the range between 1.0at% and 2.5 at%. The foregoing ranges are preferably applicable to determination within a period of 72 hours, preferably 48 hours, after the biocidal component has been deposited on the outermost surface of (i). After this period of time, the material proportion of the biocidal component may deviate slightly from the above range. In a preferred embodiment, the foregoing ranges apply to at least one biocidal component comprising or consisting of metallic silver.
The material proportion of the at least one biocidal component is preferably determined by Rutherford Backscattering Spectrometry (RBS).
Additionally, it has been found that the overall optical and antiviral and/or antibacterial properties of an ophthalmic lens can be improved if not only the coating (i) contains a certain amount of the biocidal component, but also the underlying at least one coating contains a certain amount of the biocidal component. Thus, according to a further preferred embodiment, at least one coating layer may comprise said biocidal component, preferably comprising or consisting of metallic silver, in addition to said coating layer (i).
If the at least one coating (i) comprises or consists of an anti-reflective coating or a mirror coating, said anti-reflective coating or said mirror coating each consists of at least two stacked layers. Preferably, the anti-reflective coating or the mirror coating each comprises at least two stacked layers and 20 stacked layers or less, further preferably 17 stacked layers or less, more preferably 15 stacked layers or less and most preferably 13 stacked layers or less. The outermost stacked layer thereof preferably has a layer thickness within at least one of the following ranges:
in the range of 1nm to 250nm,
In the range of 2nm to 140nm,
in the range of 3nm to 130nm,
d.4nm to 120nm,
e.5nm to 115 nm.
The aforementioned outermost stacked layer may be part of the anti-reflective coating stack or part of the mirror coating stack, or the outermost stacked layer may be an additional stacked layer of the anti-reflective coating stack or an additional stacked layer of the mirror coating stack. In both alternatives, the outermost stack is the stack furthest from the surface of the ophthalmic lens substrate with which it is coated. If the at least one coating layer (i) comprising or consisting of an anti-reflective coating layer or a mirror coating layer is deposited on both the uncoated or pre-coated front surface and the uncoated or pre-coated rear surface of the ophthalmic lens substrate, the layer thicknesses of each outermost stacked layer of the respective coating layers may be the same or different from each other.
The outermost stacked layer of the anti-reflective coating or the mirror coating further preferably comprises or consists of at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal nitride, at least one metal oxynitride and/or at least one metal sulfide, each metal preferably comprising or consisting of silicon, aluminum, zirconium and/or titanium, further preferably each metal comprises or consists of silicon. The outermost stacked layers of the anti-reflective coating or the outermost stacked layers of the mirror coating each constitute a respective matrix, preferably a silicon-based matrix, of the at least one biocidal component deposited on the outermost surface of the outermost stacked layers and at least partially diffusing at least into the outermost stacked layers.
The material proportion of the at least one biocidal component in the outermost stacked layers of the antireflective coating or specular coating is preferably within at least one of the following ranges, the biocidal component preferably comprising or consisting of metallic silver and/or metallic copper, each outermost stacked layer constituting a matrix, preferably a silicon-based matrix, of the at least one biocidal component diffusing into the outermost stacked layers:
a. on the silicon-based substrate, preferably SiO 2 The biocidal component is present in the matrix at a material fraction of less than 3.5at%,
b. on the silicon-based substrate, preferably SiO 2 The biocidal component is present in the matrix at a material fraction of less than 3.0at%,
c. on the silicon-based substrate, preferably SiO 2 The biocidal component is present in the matrix at a material fraction of less than 2.5at%,
d. on the silicon-based substrate, preferably SiO 2 The mass proportion of the biocidal component in the matrix is in the range between 0.8at% and 3.5at%,
e. on the silicon-based substrate, preferably SiO 2 The substance proportion of the biocidal component in the matrix is in the range between 0.9at% and 3.0at%,
f. on the silicon-based substrate, preferably SiO 2 Said in the matrixThe material proportion of the biocidal component is in the range between 1.0at% and 2.5 at%.
If the anti-reflective coating or the mirror coating comprises at least one further stacked layer based on at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal nitride, at least one metal oxynitride and/or at least one metal sulphide, each metal preferably comprising or consisting of silicon, the further stacked layer is capable of constituting an additional silicon-based matrix of the at least one biocidal component deposited on the outermost surface of the outermost stacked layer of the respective coating and at least partially diffused into the outermost stacked layer and into the underlying at least one stacked layer. Preferably, the anti-reflective coating or the mirror coating comprises at least one stack of layers of different composition between an outermost stack of layers and an additional stack of layers, each comprising or consisting of at least one silicon oxide, at least one silicon hydroxide, at least one silicon oxide hydrate, at least one silicon nitride, at least one silicon oxynitride and/or at least one silicon sulfide. The different composition of the at least one stacked layer therebetween preferably comprises or consists of at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal nitride, at least one metal oxynitride and/or at least one metal sulfide, each metal preferably comprising or consisting of titanium. The mass proportion of the at least one biocidal component in the additional silicon-based matrix is preferably within at least one of the following ranges, the biocidal component preferably comprising or consisting of metallic silver and/or metallic copper:
a) On the additional silicon-based matrix, preferably SiO 2 The biocidal component is present in the matrix at a material fraction of less than 0.25at%,
b) On the additional silicon-based matrix, preferably SiO 2 The biocidal component is present in the matrix at a material fraction of less than 0.2at%,
c) On the additional silicon-based matrix, preferably SiO 2 Said biocidal group in a matrixThe material proportion of the components is less than 0.15at%,
d) On the additional silicon-based matrix, preferably SiO 2 The substance proportion of the biocidal component in the matrix is in the range between 0.01at% and 0.25at%,
e) On the additional silicon-based matrix, preferably SiO 2 The substance proportion of the biocidal component in the matrix is in the range between 0.01at% and 0.2at%,
f) On the additional silicon-based matrix, preferably SiO 2 The material proportion of the biocidal component in the matrix is in the range between 0.01at% and 0.15at%.
The aforementioned ranges given above for the material ratios of the biocidal components in the additional silicon-based matrix also apply to the material ratios of the biocidal components in any silicon-based matrix other than the outermost silicon-based matrix, either an anti-reflective coating or a mirror coating.
Furthermore, the aforementioned ranges given above for the material proportions of the at least one biocidal component will apply to the corresponding substrate, irrespective of whether a single biocidal component or at least two different types of biocidal components have been deposited on the outermost surface of the at least one coating (i).
If the antireflective coating or mirror coating comprises or consists of an outermost stacked layer comprising or consisting of at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal nitride, at least one metal oxynitride and/or at least one metal sulfide, each metal preferably comprising or consisting of titanium, said outermost stacked layer constitutes a titanium-based matrix of the at least one biocidal component deposited on top of and diffused into said outermost stacked layer, preferably TiO 2 A substrate. The mass proportion of the at least one biocidal component in the titanium-based matrix is preferably within at least one of the following ranges, the biocidal component preferably comprising or consisting of metallic silver and/or metallic copper:
a. in the titanium-based matrix, preferably TiO 2 Material ratio of the biocidal components in the matrixLess than 2.0at%,
b. in the titanium-based matrix, preferably TiO 2 The biocidal component is present in the matrix at a material ratio of less than 1.8at%,
c. in the titanium-based matrix, preferably TiO 2 The biocidal component is present in the matrix at a material fraction of less than 1.7at%,
d. in the titanium-based matrix, preferably TiO 2 The substance proportion of the biocidal component in the matrix is in the range between 0.2at% and 2.0at%,
e. in the titanium-based matrix, preferably TiO 2 The mass proportion of the biocidal component in the matrix is in the range between 0.25at% and 1.8at%,
f. in the titanium-based matrix, preferably TiO 2 The material proportion of the biocidal component in the matrix is in the range between 0.3at% and 1.7 at%.
If the antireflective coating or the mirror coating comprises at least one further stacked layer based on at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal nitride, at least one metal oxynitride and/or at least one metal sulfide, each metal preferably comprising or consisting of titanium, the further stacked layer is further capable of constituting an additional titanium-based matrix of the at least one biocidal component deposited on the outermost surface of the outermost stacked layer of the respective coating and at least partially diffused into the outermost stacked layer and into the underlying at least one stacked layer, preferably TiO 2 A substrate. Preferably, at least one stack of different composition is arranged between the outermost stack and the further stack, each comprising or consisting of at least one titanium oxide, at least one titanium hydroxide, at least one titanium oxide hydrate, at least one titanium nitride, at least one titanium oxynitride and/or at least one titanium sulphide. The different compositions preferably comprise at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal nitride, at least one metal oxynitride and Or at least one metal sulphide, each metal preferably comprising or consisting of silicon and/or aluminium, preferably silicon. The mass proportion of the at least one biocidal component in the additional titanium-based matrix is preferably within at least one of the following ranges, the biocidal component preferably comprising or consisting of metallic silver and/or metallic copper:
a) In addition to the titanium-based matrix, preferably TiO 2 The biocidal component is present in the matrix at a material ratio of less than 1.5at%,
b) In addition to the titanium-based matrix, preferably TiO 2 The biocidal component is present in the matrix at a material ratio of less than 1.3at%,
c) In addition to the titanium-based matrix, preferably TiO 2 The biocidal component is present in the matrix at a material ratio of less than 1.1at%,
d) In addition to the titanium-based matrix, preferably TiO 2 The mass proportion of the biocidal component in the matrix is in the range between 0.2at% and 1.5at%,
e) In addition to the titanium-based matrix, preferably TiO 2 The mass proportion of the biocidal component in the matrix is in the range between 0.25at% and 1.3at%,
f) In addition to the titanium-based matrix, preferably TiO 2 The material proportion of the biocidal component in the matrix is in the range between 0.3at% and 1.1 at%.
As mentioned above, each material proportion is based on the total number of atoms in the respective matrix, i.e. the number of atoms of the at least one biocidal component divided by the total number of atoms in the respective matrix. Preferably, the material ratio is determined by RBS.
The ranges given above in relation to the ratio of the biocidal components in the additional titanium-based matrix will preferably apply to the ratio of the biocidal components in each additional titanium-based matrix. Further preferably, if an antireflective coating or a specular coating is deposited on the outermost stacked layers of the respective coating, the ratios of the substances given above will apply irrespective of whether a single biocidal component or at least two different types of biocidal components have been deposited on the outermost surface of the at least one coating (i).
As the at least one biocidal component at least partially diffuses at least into the at least one coating (i), the at least one biocidal component preferably forms at least two, preferably a plurality of, individual clusters of the at least one biocidal component within at least said coating (i). Preferably, each of the individual clusters has a maximum spread within at least one of the following ranges:
(i) The individual clusters have a maximum spread of less than 20nm,
(ii) The individual clusters have a maximum spread of less than 15nm,
(iii) The individual clusters have a maximum spread of less than 10nm,
(iv) The individual clusters have a maximum spread in the range of 0.5nm to 20nm,
(v) The individual clusters have a maximum spread in the range of 0.5nm to 15nm,
(vi) The individual clusters have a maximum spread in the range of 0.5nm to 10nm,
(vii) The individual clusters have a maximum spread in the range of 1nm to 20nm,
(viii) The individual clusters have a maximum spread in the range of 1nm to 15nm,
(ix) The individual clusters have a maximum spread in the range of 1nm to 10 nm.
The maximum extension of at least two of the individual clusters may be the same or different from each other, but preferably the maximum extension is within any of the aforementioned ranges. In addition to the individual clusters, the at least one biocidal component may be present at least in the coating (i) at least as at least two individual atoms, preferably a plurality of individual atoms, and/or at least two individual molecules, preferably a plurality of individual molecules in the at least one coating.
In addition to the at least one biocidal component at least partially diffusing into the at least one coating layer (i), the at least one biocidal component may also at least partially diffuse into at least one coating layer underneath said coating layer (i) and/or into the ophthalmic lens substrate. Furthermore, as previously mentioned, the at least one biocidal component may be found in any coating and/or in the ophthalmic lens substrate of an ophthalmic lens. The at least one biocidal component is preferably present in the form of at least as at least two individual atoms, preferably a plurality of individual atoms, and/or at least two individual molecules, preferably a plurality of individual molecules, and/or at least two individual clusters, preferably a plurality of individual clusters, wherever the at least one biocidal component is found. Preferably, each of the individual clusters has a maximum size within one of the aforementioned ranges. The maximum dimensions of at least two of the individual clusters may be the same or different from each other, preferably within any of the aforementioned values or ranges.
Preferably, depositing the at least one biocidal component creates at least one discontinuous layer (ii') on top of the outermost surface of the at least one coating (i). Thus, the at least one biocidal component preferably forms an island film. The island film comprises at least two individual atoms, preferably a plurality of individual atoms, of the at least one biocidal component, and/or at least two individual molecules, preferably a plurality of individual molecules, of the at least one biocidal component, and/or at least two individual clusters, preferably a plurality of individual clusters, of the at least one biocidal component. The individual clusters of the at least one biocidal component preferably form islands of an island-like film. The outermost surface of the at least one coating (i) is not covered by the at least one biocidal component between the individual clusters, the individual atoms and/or the individual molecules. The maximum dimension of each of the islands or the individual clusters, respectively, is preferably within at least one of the following ranges:
(i) The islands or the individual clusters have a maximum spread of less than 20nm,
(ii) The islands or the individual clusters have a maximum spread of less than 15nm,
(iii) The islands or the individual clusters have a maximum spread of less than 10nm,
(iv) The islands or the individual clusters have a maximum spread in the range of 0.5nm to 20nm,
(v) The islands or the individual clusters have a maximum spread in the range of 0.5nm to 15nm,
(vi) The islands or the individual clusters have a maximum spread in the range of 0.5nm to 10nm,
(vii) The islands or the individual clusters have a maximum spread in the range of 1nm to 20nm,
(viii) The islands or the individual clusters have a maximum spread in the range of 1nm to 15nm,
(ix) The islands or the individual clusters have a maximum spread in the range of 1nm to 10 nm.
The maximum dimensions of at least two of the islands or at least two of the individual clusters may be the same or different from each other, preferably with a maximum dimension in at least one of the aforementioned ranges. Maximum extension means the size with the largest extension. The maximum expansion is determined as described above.
Preferably, the at least one biocidal component comprises or consists of metallic silver, which, when deposited on the outermost surface of the at least one coating layer (i) and at least partially at least diffused into said coating layer (i), causes a photochromic effect of the ophthalmic lens, preferably a transparent lens. Section 7.5.3.2 of the ophthalmic lens according to ISO 8980-3:2013 (E) caused by the photochromic effect in the faded state has a light transmittance (τ V0 ) Transmittance (τ) of an ophthalmic lens in darkened state with section 7.5.3.3 according to ISO 8980-3:2013 (E) V1 ) The variation between is preferably within at least one of the following ranges:
(A)τ V1 /τ V0 ≤0.95，
(B)τ V1 /τ V0 ≤0.98，
(C)0.95≤τ V1 /τ V0 ≤0.995，
(D)0.98≤τ V1 /τ V0 ≤0.995，
(E)0.985≤τ V1 /τ V0 ≤0.995。
photochromic effects within at least one of the foregoing ranges include adjusting the transmission characteristics and antimicrobial and/or antiviral characteristics so as to meet the needs of an ophthalmic lens wearer for increased and/or sufficient transparency and increased and/or sufficient health-related antiviral and/or antibacterial effects.
In a preferred but optional further embodiment, the light transmittance in the faded state τ as defined in section 7.5.3.2 of ISO 8980-3:2013 (E) V0 Values exceeding 95%, preferably 96%, most preferably 97%.
In a preferred embodiment, the ophthalmic lens comprises the at least one coating (i) and at least two individual metallic silver atoms, preferably a plurality of individual metallic silver atoms, and/or at least two metallic silver clusters, preferably a plurality of individual metallic silver clusters (ii), as previously described, metallic silver is present not only on top of the outermost surface of the at least one coating (i) due to diffusion, but also throughout the entire ophthalmic lens, i.e. coating and ophthalmic lens base. Preferably, the total content of metallic silver of the spectacle lens is k=5.10 -4 To 1.10 -4 More preferably k=8·10 -4 To 8.10 -2 And most preferably 1.10 -3 To 5.10 -2 Within the range of (1), in whichAnd ≡ag_s=the integral of metallic silver measured in the spectacle lens and ≡ag_0=the integral of metallic silver measured in the pure silver lens as reference, as determined by energy dispersive x-ray spectrometry (EDX) from the top of the front and/or rear surface of the spectacle lens as described above with respect to the first embodiment.
In a more preferred embodiment, the ophthalmic lens comprises at least one coating layer (i) and at least two individual metallic silver atoms, preferably a plurality of individual metallic silver atoms, and/or at least two clusters comprising or consisting of metallic silver, preferably a plurality of individual clusters comprising or consisting of metallic silver (ii). The individual atoms and/or clusters are located on top of the outermost surface of the at least one coating layer (i) and, as previously described, at least partially diffuse in the at least one coating layer (i), optionally in at least one coating layer underneath said at least one coating layer (i) and/or in the ophthalmic lens substrate. The total content of metallic silver of the ophthalmic lens is preferably in the range from 0.05at% to 0.50at%, more preferably from 0.08at% to 0.45at% and most preferably from 0.10at% to 0.40 at%. The total content of metallic silver is preferably determined by EDX mapping onto an ophthalmic lens as described previously with respect to the first embodiment.
A second additional or alternative embodiment of the invention is directed to a method for manufacturing an ophthalmic lens comprising an ophthalmic lens substrate and
(i) At least one of the layers of the coating,
(ii) At least one composite layer comprising at least one biocidal component, preferably at least two individual atoms of the at least one biocidal component, further preferably a plurality of individual atoms, and/or at least two molecules of the at least one biocidal component, further preferably a plurality of individual molecules, and/or at least two individual clusters of the at least one biocidal component, further preferably a plurality of individual clusters, the at least one composite layer preferably being located on top of the outermost surface of the at least one coating (i), and
(iii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens,
the method at least comprises the following steps:
applying or depositing the at least one coating (i) onto at least one uncoated or pre-coated surface of the ophthalmic lens substrate, preferably onto an uncoated or pre-coated front surface of the ophthalmic lens substrate,
Depositing at least one biocidal component onto the outermost surface of the at least one coating layer (i), preferably by evaporation, optionally by evaporation with the aid of an ion beam, further preferably with a nominal layer thickness of less than 12nm, further preferably less than 10nm, further preferably less than 9nm, more preferably less than 7nm and most preferably less than 6nm, the deposited at least one biocidal component forming at least one island-like or discontinuous layer (ii') comprising or consisting of the at least one biocidal component,
-depositing at least one compound on the outermost surface of the at least one coating layer (i) and/or on the outermost surface of the at least one discontinuous layer (ii'), preferably by evaporation, further preferably by evaporation with the aid of an ion beam, further preferably at a nominal layer thickness of less than 12nm, further preferably less than 10nm, further preferably less than 9nm, more preferably less than 7nm and most preferably less than 6nm, and optionally
-applying the at least one coating (iii) to the outermost surface obtained in the preceding step.
The individual steps according to the method described above are consecutive steps. Preferably, the at least one coating (i) is applied to the uncoated or pre-coated front surface and/or the uncoated or pre-coated rear surface of the ophthalmic lens substrate, followed by the deposition of the at least one biocidal component (ii) on the outermost surface of the at least one coating (i), and followed by the deposition of the at least one compound on the outermost surface of the at least one coating (i) and/or on the outermost surface of the at least one discontinuous layer (ii'). Optionally, the at least one coating (iii) is subsequently applied.
The deposited at least one compound preferably produces at least one component selected from the group consisting of at least one metal oxide, at least one metal hydroxide, at least one metal oxide hydrate, at least one metal nitride, at least one metal oxynitride and at least one metal sulfide, each component comprising or consisting of at least one metal selected from the group consisting of silicon, titanium, aluminum and zirconium. Depositing the at least one compound in an additional subsequent step yields a composite layer comprising the at least one biocidal component and the at least one component, as compared to the first embodiment involving the method. The composite layer preferably comprises at least two separate atoms of at least one biocidal component and/or at least two separate molecules of at least one biocidal component and/or at least two separate clusters of at least one biocidal component within a matrix formed by subsequently deposited at least one compound that produces the at least one component.
The description and the explanation given will also apply in relation to the at least one coating (i) and the at least one biocidal component described above, at least in relation to the first embodiment relating to the method and in relation to the first embodiment relating to the ophthalmic lens.
As has been explained in further detail at least in relation to the first embodiment relating to the method, the at least one biocidal component at least partially diffuses at least in the at least one coating (i). In this second embodiment relating to the method, the at least one biocidal component is additionally at least partially diffused within the at least one composite layer. Such at least partial diffusion of the biocidal component within the composite layer results in formation of at least two individual atoms, preferably a plurality of individual atoms, of the biocidal component, and/or at least two individual molecules, preferably a plurality of individual molecules, of the biocidal component, and/or at least two individual clusters, preferably a plurality of individual clusters, of the biocidal component, each within the composite layer. The maximum extension given above in relation to the individual clusters also applies to the second embodiment relating to the method. The at least partial diffusion within the composite layer includes diffusion of the biocidal component in a random direction. The at least partial diffusion of the biocidal component within the composite layer may be accelerated as described above in relation to the first embodiment of the method.
The nominal layer thickness of the composite layer is preferably in the range from 0.2nm to 12nm, further preferably from 0.4nm to 10nm, more preferably from 0.6nm to 9nm, more preferably from 0.7nm to 7nm and most preferably from 0.8nm to 6 nm. The definition of the nominal layer thickness is given in relation to the first embodiment relating to the method. A composite layer having a nominal layer thickness in the aforementioned range ensures that the desired optical properties of the ophthalmic lens are not degraded, while at the same time ensuring a sufficient antimicrobial and/or antiviral efficacy of the ophthalmic lens.
The mass proportion of the at least one biocidal component in the composite layer is preferably within at least one of the following ranges:
a. the biocidal component has a material proportion in the composite layer of less than 7.0at%,
b. the biocidal component has a material proportion in the composite layer of less than 6.3at%,
c. the biocidal component has a material proportion in the composite layer of less than 5.2at%,
d. the proportion of the biocidal component in the composite layer is in the range between 0.7at% and 7.0at%,
e. the mass proportion of the biocidal component in the composite layer is in the range between 0.8at% and 6.3at%,
f. the mass proportion of the biocidal component in the composite layer is in the range between 0.9at% and 5.2 at%.
The material proportion of the at least one biocidal component in the composite layer, which preferably comprises silicon oxide, preferably SiO, is preferably within at least one of the following ranges 2 ：
a. The biocidal component has a material proportion in the composite layer of less than 3.0at%,
b. the biocidal component has a material proportion in the composite layer of less than 2.8at%,
c. The biocidal component has a material proportion in the composite layer of less than 2.6at%,
d. the biocidal component has a material proportion in the composite layer of less than 2.5at%,
e. the proportion of the biocidal component in the composite layer is in the range between 0.7at% and 3.0at%,
f. the mass proportion of the biocidal component in the composite layer is in the range between 0.8at% and 2.8at%,
g. the mass proportion of the biocidal component in the composite layer is in the range between 0.9at% and 2.6at%,
h. the mass proportion of the biocidal component in the composite layer is in the range between 1.0at% and 2.6 at%.
The aforementioned ranges of material ratios will preferably apply to a single biocidal component or at least two different types of biocidal components present in the composite layer. The material ratios are defined and determined as described above.
The above mentioned ranges will also apply in relation to the first embodiment relating to the method in relation to the material proportion of the biocidal component in any other coating or stacking layer of the ophthalmic lens or in relation to the material proportion of the biocidal component in the ophthalmic lens.
The ranges given above in relation to the first embodiment relating to the method will also apply in relation to the photochromic effect caused by at least one biocidal component comprising or consisting of metallic silver.
The aforementioned subsequent deposition of the at least one biocidal component and the at least one compound has the advantage that only a single evaporation source is required. As mentioned in relation to the first embodiment relating to the method, the evaporation is preferably electron beam gun evaporation, further preferably electron beam gun evaporation with the aid of an ion beam, the ion source also having been mentioned above. A further advantage of the subsequent deposition is that the deposition rate of the deposited at least one biocidal component and the deposition rate of the subsequently deposited at least one compound constituting the matrix of the at least one biocidal component are each measurable and controllable. Preferably, the respective deposition rates are measured during deposition via a quartz crystal microbalance. A further advantage is that the nominal layer thickness of the deposited at least one biocidal component and the subsequently deposited nominal layer thickness of the at least one compound constituting the matrix of the at least one biocidal component are each measurable and controllable. Thus, the material ratio and total amount of the at least one biocidal component and the material ratio of the subsequently deposited at least one compound are also indirectly measurable and controllable, thus in turn providing a good control of the antibacterial and/or antiviral properties of the resulting ophthalmic lens. Furthermore, compared to such a composite layer resulting from co-evaporation of the at least one biocidal component and the at least one compound constituting the matrix of the at least one biocidal component, as for example described in PCT/CN 2020/128598, no subsequent extensive analysis is required, such as for example EDX (energy dispersive x-ray spectroscopy), XRF (x-ray fluorescence spectroscopy), GD-OES (glow discharge emission spectroscopy), for example to maintain the process stability of at least one of the previous embodiments of the method with respect to the material ratio referring to the at least one biocidal component.
Any definition given in relation to the aforementioned first embodiment relating to a method will also apply to the second embodiment relating to a method.
A third additional or alternative embodiment of the invention is directed to a method for manufacturing an ophthalmic lens comprising an ophthalmic lens substrate and
(i) At least two individual atoms, preferably a plurality of individual atoms, of at least one biocidal component, and/or at least two individual molecules, preferably a plurality of individual molecules, of at least one biocidal component, and/or at least two individual clusters, preferably a plurality of individual clusters, of at least one biocidal component, preferably the at least two individual atoms and/or the at least two individual molecules and/or the at least two individual clusters are located on at least one of the uncoated surfaces of the ophthalmic lens substrate,
(ii) Optionally at least one coating (i), and
(iii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens,
the method at least comprises the following steps:
depositing at least one biocidal component onto at least one of the uncoated surfaces of the ophthalmic lens substrate, preferably by evaporation, optionally by evaporation with the aid of an ion beam, further preferably with a nominal layer thickness of less than 12nm, further preferably less than 10nm, further preferably less than 9nm, more preferably less than 7nm and most preferably less than 6nm, the deposited at least one biocidal component forming at least one island-like film or discontinuous layer (ii') comprising or consisting of the at least one biocidal component,
-optionally applying the at least one coating (i) onto the uncoated surface of the ophthalmic lens substrate and/or onto the outermost surface of the at least one discontinuous layer (ii'), and
-optionally applying the at least one coating (iii) onto the uncoated surface of the ophthalmic lens substrate and/or onto the outermost surface of the at least one discontinuous layer (ii'); or optionally applying the at least one coating (iii) to the outermost surface of the at least one coating (i).
The individual steps according to the method described above are consecutive steps. The definitions and explanations given above in relation to at least the first and second embodiments of the related method will also apply in relation to the third embodiment of the related method.
Due to the above-described diffusion of the at least one biocidal component, in particular into the spectacle lens substrate, the substance proportion of the at least one biocidal component in the spectacle lens substrate is preferably in the range of 0.005at% to 0.01 at%.
A fourth additional or alternative embodiment of the invention is directed to a method for manufacturing an ophthalmic lens comprising an ophthalmic lens substrate and
(i) At least one composite layer comprising at least one biocidal component, the at least one composite layer preferably being located on at least one of the uncoated surfaces of the ophthalmic lens substrate,
(ii) Optionally at least one coating (i), preferably on the outermost surface of the at least one composite layer,
(iii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens,
the method at least comprises the following steps:
depositing at least one biocidal component, preferably by evaporation, optionally by evaporation with the aid of an ion beam, further preferably at a nominal layer thickness of less than 12nm, further preferably less than 10nm, further preferably less than 9nm, more preferably less than 7nm and most preferably less than 6nm, on the outermost surface of at least one of the uncoated surfaces of the ophthalmic lens substrate, the deposited at least one biocidal component forming at least one island film or discontinuous layer (ii') comprising or consisting of the at least one biocidal component,
depositing at least one compound on the uncoated surface of the ophthalmic lens substrate and/or on the outermost surface of the at least one discontinuous layer (ii'), preferably by evaporation, further preferably by evaporation with the aid of an ion beam, further preferably at a nominal layer thickness of less than 12nm, further preferably less than 10nm, further preferably less than 9nm, more preferably less than 7nm and most preferably less than 6nm,
-optionally applying the at least one coating layer (i) preferably onto the outermost surface of the composite layer obtained in the preceding step, and
-optionally applying the at least one coating layer (iii) preferably to the outermost surface of the at least one composite layer or to the outermost surface of the at least one coating layer (i).
The individual steps according to the method described above are consecutive steps. The definitions and explanations given above in particular in relation to the second embodiment of the related method will also apply in relation to the fourth embodiment of the related method.
A fifth additional or alternative embodiment of the invention is directed to a method for manufacturing an ophthalmic lens comprising an ophthalmic lens substrate and
(i) At least one coating (i) comprising at least one anti-reflective coating or at least one mirror coating, said anti-reflective coating or said mirror coating each comprising at least two stacked layers, wherein one stacked layer is the outermost stacked layer, wherein at least one of said stacked layers comprises at least one biocidal component, preferably at least two separate atoms of the at least one biocidal component, further preferably a plurality of separate atoms, and/or at least two molecules of the at least one biocidal component, further preferably a plurality of separate molecules, and/or at least two separate clusters of the at least one biocidal component, further preferably a plurality of separate clusters, and
(ii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens,
the method at least comprises the following steps:
depositing at least one biocidal component on the outermost surface of at least one of said stacked layers, preferably by evaporation, optionally by evaporation with the aid of an ion beam, further preferably with a nominal layer thickness of less than 12nm, further preferably less than 10nm, further preferably less than 9nm, more preferably less than 7nm and most preferably less than 6nm, the deposited at least one biocidal component forming at least one island-like film or discontinuous layer (ii') comprising or consisting of the at least one biocidal component,
-depositing at least one compound on the outermost surface of the stacked layers and/or on the outermost surface of the discontinuous layer (ii'), preferably by evaporation, further preferably by evaporation with the aid of an ion beam, and
-optionally applying the at least one coating (iii) to the outermost stacked layer of the anti-reflective coating or the mirror coating.
In this fifth embodiment relating to a method, the at least one biocidal component as described previously may be deposited on the outermost surface of any stacked layers of an anti-reflective coating or a specular coating. Whether or not the at least one biocidal component is deposited on the stacked layers immediately adjacent to the uncoated or pre-coated ophthalmic lens substrate and/or on the stacked layers below the outermost stacked layers, in particular the partial diffusion of said biocidal component creating individual clusters as described previously may occur at least throughout the entire respective layer stack.
The definition given above applies also in relation to the fifth embodiment relating to the method.
In addition to or as an alternative to the at least one coating (i) being an anti-reflective coating or a mirror coating, the at least one coating (i) may comprise another of the aforementioned coatings (i), for example a hard coating. The at least one biocidal component subsequently deposited may at least partially diffuse into the hard coating and may then be overcoated by a further coating, such as an anti-reflective coating.
The ophthalmic lens according to the present invention may be in the form of at least one selected from the group consisting of:
in the form of computer-readable instructions stored on a computer-readable data carrier for its manufacture,
In the form of computer-readable data stored on a computer-readable data carrier,
in the form of computer-readable instructions for its production which are converted into data carrier signals,
in the form of a data carrier signal,
in the form of a digital data set,
in the form of a data signal conveying a digital data set,
in the form of a data carrier storing digital data sets.
The ophthalmic lens according to the present invention, in particular according to all embodiments of the present invention, may comprise at least one selected from the group consisting of:
at least two separate atoms of at least one biocidal component,
at least two separate molecules of at least one biocidal component,
at least two individual clusters of at least one biocidal component.
In summary, the following examples are particularly preferred within the scope of the invention:
example 1: an ophthalmic lens comprising an ophthalmic lens substrate and at least one coating, said ophthalmic lens substrate comprising a front surface and a back surface, and said ophthalmic lens substrate comprising said at least one coating on at least one of said surfaces, wherein said at least one coating comprises
(i) At least one coating selected from the group consisting of at least one hard coating, at least one anti-reflective coating, and at least one specular coating,
(ii) At least two individual metallic silver atoms, preferably a plurality of individual atoms; and/or at least two individual molecules, preferably a plurality of individual molecules, selected from at least one of the group consisting of at least one silver oxide, at least one silver hydroxide, at least one silver oxide hydrate, at least one silver nitride, at least one silver oxynitride and at least one silver sulfide; and/or at least two metallic silver clusters, preferably a plurality of individual clusters, said at least two atoms and/or said at least two molecules and/or said at least two clusters preferably being at least partially located on the outermost surface of said at least one coating (i),
(iii) Optionally at least one coating selected from at least one of the group consisting of at least one cleaning coating and at least one anti-fog coating.
Example 2: an ophthalmic lens comprising an ophthalmic lens substrate and at least one coating, said ophthalmic lens substrate comprising a front surface and a back surface, and said ophthalmic lens substrate comprising said at least one coating on at least one of said surfaces, wherein said at least one coating comprises
(i) At least one coating selected from the group consisting of at least one hard coating, at least one anti-reflective coating, and at least one specular coating,
(ii) At least two individual metallic silver atoms, preferably a plurality of individual atoms, and/or at least two individual metallic silver clusters, preferably a plurality of individual clusters, said at least two atoms and/or said at least two clusters preferably being at least partially located on the outermost surface of said at least one coating (i),
(iii) Optionally at least one coating selected from the group consisting of at least one cleaning coating and at least one anti-fog coating,
and wherein the transmittance (τ) of the ophthalmic lens in the faded state according to section 7.5.3.2 of ISO 8980-3:2013 (E) V0 ) Transmittance (τ) of an ophthalmic lens in darkened state with section 7.5.3.3 according to ISO 8980-3:2013 (E) V1 ) The variation between is within one of the following groups:
(A)τ V1 /τ V0 ≤0.95，
(B)τ V1 /τ V0 ≤0.98，
(C)0.95≤τ V1 /τ V0 ≤0.995，
(D)0.98≤τ V1 /τ V0 ≤0.995，
(E)0.985≤τ V1 /τ V0 ≤0.995。
example 3: an ophthalmic lens comprising an ophthalmic lens substrate and at least one coating, said ophthalmic lens substrate comprising a front surface and a back surface, at least one of these surfaces of said ophthalmic lens substrate comprising glass, wherein at least said surface of said ophthalmic lens substrate comprising glass comprises
(i) At least one anti-reflection coating, preferably one anti-reflection coating, comprising at least, starting from the surface of the ophthalmic lens substrate to be coated therewith
a)0.41622·λ 0 4.M to 0.89369.lambda. 0 /4·M；0.25968·λ 0 4-L to 0.41206-lambda 0 /4·L；0.41001·λ 0 4.M to 0.76121.lambda. 0 /4·M；0.57225·λ 0 4-L to 0.98335-lambda 0 /4·L；0.65779·λ 0 4.M to 0.88071.lambda. 0 /4·M；0.07069·λ 0 4.H to 0.16235.lambda 0 /4·H；0.47009·λ 0 4.M to 0.74670.lambda. 0 /4·M；0.22075·λ 0 4.H to 0.44188.lambda 0 /4·H；0.97592·λ 0 4-L to 1.37164-lambda 0 4.L; or (b)
b)0.64253·λ 0 4.M to 0.89614.lambda. 0 /4·M；0.08183·λ 0 4-L to 0.35676-lambda 0 /4·L；0.80796·λ 0 4.M to 0.32864.lambda. 0 /4·M；0.75891·λ 0 4-L to 1.02867-lambda 0 /4·L；0.90476·λ 0 4.M to 1.41535.lambda. 0 /4·M；0.10051·λ 0 4.H to 0.21603.lambda 0 /4·H；0.00287·λ 0 4.M to 0.45506.lambda. 0 /4·M；0.80453·λ 0 4-L to 1.27591-lambda 0 4.L; or (b)
c)0.19459·λ 0 4-L to 0.23394-lambda 0 /4·L；0.48912·λ 0 4.M to 0.77248.lambda. 0 /4·M；0.32489·λ 0 4-L to 0.61648-lambda 0 /4·L；0.36292·λ 0 4.M to 0.54573.lambda. 0 /4·M；0.48976·λ 0 4-L to 0.80061-lambda 0 /4·L；0.59960·λ 0 4.M to 0.83505.lambda. 0 /4·M；0.10179·λ 0 4.H to 0.23052.lambda 0 /4·H；0.50401·λ 0 4.M to 0.70778.lambda. 0 /4·M；0.30008·λ 0 4.H to 0.48019.lambda 0 /4·H；0.99344·λ 0 4-L to 1.35331-lambda 0 /4·L，
In the anti-reflective coatings a), b), c), each M has a wavelength dependent refractive index ranging from 1.632 at 380nm to 1.599 at 780nm, preferably from 1.614 at 500nm to 1.606 at 600 nm; or each M has a wavelength dependent refractive index ranging from 1.750 at 380nm to 1.701 at 780nm, preferably from 1.724 at 500nm to 1.712 at 600 nm; each L has a wavelength dependent refractive index ranging from 1.473 at 380nm to 1.456 at 780nm, preferably having a wavelength dependent refractive index of 1.462 at 500nm to 1.459 at 600 nm; each H has a wavelength dependent refractive index ranging from 2.832 at 380nm to 2.270 at 780nm, preferably 2.440 at 500nm and 2.336 at 600nm, and in the anti-reflective coating a), b), c), lambda 0 In the range from 500nm to 600nm,
(ii) At least two individual metallic silver atoms, preferably a plurality of individual atoms; and/or at least two individual molecules, preferably a plurality of individual atoms, selected from at least one of the group consisting of at least one silver oxide, at least one silver hydroxide, at least one silver oxide hydrate, at least one silver nitride, at least one silver oxynitride and at least one silver sulfide; and/or at least two individual metallic silver clusters, preferably a plurality of individual clusters, said at least two atoms and/or said at least two molecules and/or said at least two clusters preferably being located at least partially on the outermost surface of said at least one anti-reflective coating (i),
(iii) Optionally at least one coating selected from at least one of the group consisting of at least one cleaning coating and at least one anti-fog coating.
Example 4: an ophthalmic lens comprising an ophthalmic lens substrate and at least one coating, said ophthalmic lens substrate comprising a front surface and a back surface, and said ophthalmic lens substrate comprising said at least one coating on at least one of said surfaces, wherein said at least one coating comprises
(i) At least one coating selected from the group consisting of at least one hard coating, at least one anti-reflective coating, and at least one specular coating,
(ii) At least two individual metallic copper atoms, preferably a plurality of individual atoms; and/or at least two individual molecules, preferably a plurality of individual molecules, selected from at least one of the group consisting of at least one copper oxide, at least one copper hydroxide, at least one copper oxide hydrate, at least one copper nitride, at least one copper oxynitride and at least one copper sulphide; and/or at least two metallic copper clusters, preferably a plurality of individual clusters, said at least two atoms and/or said at least two molecules and/or said at least two clusters being preferably located at least partially on the outermost surface of said at least one coating (i),
(iii) Optionally at least one coating selected from at least one of the group consisting of at least one cleaning coating and at least one anti-fog coating.
Example 5: an ophthalmic lens comprising an ophthalmic lens substrate and at least one coating, said ophthalmic lens substrate comprising a front surface and a back surface, at least one of these surfaces of said ophthalmic lens substrate comprising glass, wherein at least said surface of said ophthalmic lens substrate comprising glass comprises
(i) At least one anti-reflection coating, preferably one anti-reflection coating, comprising at least, starting from the surface of the ophthalmic lens substrate to be coated therewith
a)0.41622·λ 0 4.M to 0.89369.lambda. 0 /4·M；0.25968·λ 0 4-L to 0.41206-lambda 0 /4·L；0.41001·λ 0 4.M to 0.76121.lambda. 0 /4·M；0.57225·λ 0 4-L to 0.98335-lambda 0 /4·L；0.65779·λ 0 4.M to 0.88071.lambda. 0 /4·M；0.07069·λ 0 4.H to 0.16235.lambda 0 /4·H；0.47009·λ 0 4.M to 0.74670.lambda. 0 /4·M；0.22075·λ 0 4.H to 0.44188.lambda 0 /4·H；0.97592·λ 0 4-L to 1.37164-lambda 0 4.L; or (b)
b)0.64253·λ 0 4.M to 0.89614.lambda. 0 /4·M；0.08183·λ 0 4-L to 0.35676-lambda 0 /4·L；0.80796·λ 0 4.M to 0.32864.lambda. 0 /4·M；0.75891·λ 0 4-L to 1.02867-lambda 0 /4·L；0.90476·λ 0 4.M to 1.41535.lambda. 0 /4·M；0.10051·λ 0 4.H to 0.21603.lambda 0 /4·H；0.00287·λ 0 4.M to 0.45506.lambda. 0 /4·M；0.80453·λ 0 4-L to 1.27591-lambda 0 4.L; or (b)
c)0.19459·λ 0 4-L to 0.23394-lambda 0 /4·L；0.48912·λ 0 4.M to 0.77248.lambda. 0 /4·M；0.32489·λ 0 4-L to 0.61648-lambda 0 /4·L；0.36292·λ 0 4.M to 0.54573.lambda. 0 /4·M；0.48976·λ 0 4-L to 0.80061-lambda 0 /4·L；0.59960·λ 0 4.M to 0.83505.lambda. 0 /4·M；0.10179·λ 0 4.H to 0.23052.lambda 0 /4·H；0.50401·λ 0 4.M to 0.70778.lambda. 0 /4·M；0.30008·λ 0 4.H to 0.48019.lambda 0 /4·H；0.99344·λ 0 4-L to 1.35331-lambda 0 /4·L，
In the anti-reflection coatings a), b), c), each M has a wavelength dependent refractive index ranging from 1.632 at 380nm to 1.599 at 780nm, preferably 1.614 at 500nm to 1.606 at 600nmWavelength dependent refractive index of (a); or each M has a wavelength dependent refractive index ranging from 1.750 at 380nm to 1.701 at 780nm, preferably from 1.724 at 500nm to 1.712 at 600 nm; each L has a wavelength dependent refractive index ranging from 1.473 at 380nm to 1.456 at 780nm, preferably having a wavelength dependent refractive index of 1.462 at 500nm to 1.459 at 600 nm; each H has a wavelength dependent refractive index ranging from 2.832 at 380nm to 2.270 at 780nm, preferably 2.440 at 500nm and 2.336 at 600nm, and in the anti-reflective coating a), b), c), lambda 0 In the range from 500nm to 600nm,
(ii) At least two individual metallic copper atoms, preferably a plurality of individual atoms; and/or at least two individual molecules, preferably a plurality of individual atoms, selected from at least one of the group consisting of at least one copper oxide, at least one copper hydroxide, at least one copper oxide hydrate, at least one copper nitride, at least one copper oxynitride and at least one copper sulphide; and/or at least two individual metallic copper clusters, preferably a plurality of individual clusters, said at least two atoms and/or said at least two molecules and/or said at least two clusters being preferably located at least partially on the outermost surface of said at least one anti-reflective coating (i),
(iii) Optionally at least one coating selected from at least one of the group consisting of at least one cleaning coating and at least one anti-fog coating.
Example 6: a product, the product comprising:
i) Ophthalmic lens or description of ophthalmic lens, or
ii) an ophthalmic lens and instructions for use of the ophthalmic lens, or a description of an ophthalmic lens and instructions for use of the ophthalmic lens, or
iii) At least one description of the ophthalmic lens in the form of computer-readable data stored on a computer-readable medium, or
iv) at least one description of the ophthalmic lens and instructions for using the ophthalmic lens, each in the form of computer-readable data, and each stored on a computer-readable medium, or
v) a computer readable medium comprising at least one description of the ophthalmic lens in the form of computer readable data, or
vi) a computer readable medium comprising at least one description of the ophthalmic lens and at least one description of instructions for using the ophthalmic lens, each in the form of computer readable data, or
vii) at least one description of the ophthalmic lens in the form of a computer-readable data signal, or
viii) at least one description of the ophthalmic lens and at least one description of a description of the use of the ophthalmic lens, each in the form of a computer readable data signal,
ix) a computer readable data signal comprising at least one description of the ophthalmic lens in the form of computer readable data, or
x) a computer readable data signal comprising at least one description of the ophthalmic lens and at least one description of an instruction to use the ophthalmic lens, each in the form of computer readable data,
wherein the ophthalmic lens or the description of the ophthalmic lens each comprises an uncoated or pre-coated ophthalmic lens substrate, and
(i) At least one of the layers of the coating,
(ii) At least two individual atoms, preferably a plurality of individual atoms, of the at least one biocidal component, and/or at least two individual molecules, preferably a plurality of individual molecules, of the at least one biocidal component, and/or at least two individual clusters, preferably a plurality of individual clusters, of the at least one biocidal component, the at least two individual atoms and/or the at least two individual molecules and/or the at least two individual clusters each being at least partially located on top of the outermost surface of the at least one coating (i), and
(iii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating, and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens.
Example 7: the product according to the foregoing embodiment 6, wherein the description of the ophthalmic lens is selected from the group consisting of at least one of the following: at least one surface topography of the ophthalmic lens, at least one surface topography of the ophthalmic lens substrate, at least an optical material comprising the ophthalmic lens substrate, and at least the coating.
Example 8: the product according to any of the preceding embodiments 6 or 7, wherein the instructions for using the ophthalmic lens are selected from the group consisting of: center point location defined according to ISO 13666:2019 (E), section 3.2.35; according to ISO 13666:2019 (E), section 3.2.29 defines a profile angle; vertex distance defined according to ISO 13666:2019 (E), section 3.2.40; distance reference points defined according to ISO 13666:2019 (E), section 3.2.20; and optionally a near reference point defined according to ISO 13666:2019 (E), section 3.2.21.
Example 9: the product according to any of the preceding embodiments 6 to 8, wherein the description of the ophthalmic lens is similar to the description of the instructions for using the ophthalmic lens, preferably in paper form.
Example 10: a method for manufacturing an ophthalmic lens comprising an ophthalmic lens substrate and
(i) At least one of the layers of the coating,
(ii) At least two individual metallic silver atoms, preferably a plurality of individual atoms, and/or at least two individual metallic silver clusters, preferably a plurality of individual clusters, preferably the at least two individual atoms and/or the at least two individual clusters are located on top of the outermost surface of the at least one coating (i), and
(iii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens,
the method at least comprises the following steps:
applying or depositing the at least one coating (i) onto at least one uncoated or pre-coated surface of the ophthalmic lens substrate, preferably onto at least the uncoated or pre-coated front surface of the ophthalmic lens substrate,
-depositing metallic silver on the outermost surface of the at least one coating layer (i), preferably by evaporation, optionally by evaporation with the aid of an ion beam, further preferably with a nominal layer thickness of less than 12nm, further preferably less than 10nm, more preferably less than 8nm and most preferably less than 6nm, the deposited metallic silver forming at least one island-like or discontinuous layer (ii') comprising or consisting of metallic silver, and optionally
-applying the at least one coating (iii) to the outermost surface of the at least one coating (i) and/or to the outermost surface of the at least one discontinuous layer (ii').
Example 11: a method for manufacturing an ophthalmic lens comprising an ophthalmic lens substrate and
(i) At least one of the layers of the coating,
(ii) At least one composite layer comprising at least two individual metallic silver atoms, preferably a plurality of individual atoms, and/or at least two individual metallic silver clusters, preferably a plurality of individual clusters, preferably on top of the outermost surface of the at least one coating layer (i), and
(iii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens,
The method at least comprises the following steps:
applying or depositing the at least one coating (i) onto at least one uncoated or pre-coated surface of the ophthalmic lens substrate, preferably onto an uncoated or pre-coated front surface of the ophthalmic lens substrate,
depositing metallic silver on the outermost surface of the at least one coating layer (i), preferably by evaporation, optionally by evaporation with the aid of an ion beam, further preferably with a nominal layer thickness of less than 12nm, further preferably less than 10nm, further preferably less than 9nm, more preferably less than 7nm and most preferably less than 6nm, the deposited metallic silver forming at least one island-like or discontinuous layer (ii') comprising or consisting of metallic silver,
-depositing at least one compound, preferably silicon oxide, on the outermost surface of the at least one coating layer (i) and/or on the outermost surface of the at least one discontinuous layer (ii'), preferably by evaporation, further preferably by evaporation with the aid of an ion beam, further preferably at a nominal layer thickness of less than 12nm, further preferably less than 10nm, further preferably less than 9nm, more preferably less than 7nm and most preferably less than 6nm, and optionally
-applying the at least one coating (iii) to the outermost surface obtained in the preceding step.
Example 12: a method for manufacturing an ophthalmic lens comprising an ophthalmic lens substrate and
(i) At least two individual metallic silver atoms, preferably a plurality of individual atoms, and/or at least two individual metallic silver clusters, preferably a plurality of individual clusters, preferably the at least two individual atoms and/or the at least two individual clusters are located on at least one of the uncoated surfaces of the ophthalmic lens substrate,
(ii) Optionally at least one coating (i), and
(iii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens,
the method at least comprises the following steps:
depositing metallic silver on at least one of the uncoated surfaces of the ophthalmic lens substrate, preferably by evaporation, optionally by evaporation with the aid of an ion beam, further preferably with a nominal layer thickness of less than 12nm, further preferably less than 10nm, further preferably less than 9nm, more preferably less than 7nm and most preferably less than 6nm, the deposited metallic silver forming at least one island film or discontinuous layer (ii') comprising or consisting of metallic silver,
-optionally applying the at least one coating (i) onto the uncoated surface of the ophthalmic lens substrate and/or onto the outermost surface of the at least one discontinuous layer (ii'), and
-optionally applying the at least one coating (iii) onto the uncoated surface of the ophthalmic lens substrate and/or onto the outermost surface of the at least one discontinuous layer (ii'); or optionally applying the at least one coating (iii) to the outermost surface of the at least one coating (i).
Example 13: a method for manufacturing an ophthalmic lens comprising an ophthalmic lens substrate and
(i) At least one composite layer comprising at least two individual metallic silver atoms, preferably a plurality of individual atoms, and/or at least two individual metallic silver clusters, preferably a plurality of individual clusters, the at least one composite layer preferably being located on at least one of the uncoated surfaces of the ophthalmic lens substrate,
(ii) Optionally at least one coating (i), preferably on the outermost surface of the at least one composite layer,
(iii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens,
The method at least comprises the following steps:
depositing at least one biocidal component on the outermost surface of at least one of the uncoated surfaces of the ophthalmic lens substrate, optionally by evaporation with the aid of an ion beam, further preferably with a nominal layer thickness of less than 12nm, further preferably less than 10nm, further preferably less than 9nm, more preferably less than 7nm and most preferably less than 6nm, the deposited metallic silver forming at least one island film or discontinuous layer (ii') comprising or consisting of metallic silver,
depositing at least one compound, preferably silicon oxide, titanium oxide or zirconium oxide, on the uncoated surface of the ophthalmic lens substrate and/or on the outermost surface of the at least one discontinuous layer (ii'), preferably by evaporation, further preferably by evaporation with the aid of an ion beam, further preferably at a nominal layer thickness of less than 12nm, further preferably less than 10nm, further preferably less than 9nm, more preferably less than 7nm and most preferably less than 6nm,
-optionally applying the at least one coating layer (i) preferably onto the outermost surface of the composite layer obtained in the preceding step, and
-optionally applying the at least one coating layer (iii) preferably to the outermost surface of the at least one composite layer or to the outermost surface of the at least one coating layer (i).
Example 14: a method for manufacturing an ophthalmic lens comprising an ophthalmic lens substrate and
(i) At least one coating (i) comprising at least one anti-reflective coating or at least one mirror coating, each comprising at least two stacked layers, wherein one stacked layer is the outermost stacked layer, wherein at least one of the stacked layers comprises metallic silver, preferably at least two individual metallic silver atoms, further preferably a plurality of individual atoms, and/or at least two individual metallic silver clusters, further preferably a plurality of individual clusters, and
(ii) Optionally at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating and at least one anti-fog coating, the optional at least one coating being the outermost coating of the ophthalmic lens,
the method at least comprises the following steps:
depositing at least one biocidal component on the outermost surface of at least one of said stacked layers, preferably by evaporation, optionally by evaporation with the aid of an ion beam, further preferably with a nominal layer thickness of less than 12nm, further preferably less than 10nm, further preferably less than 9nm, more preferably less than 7nm and most preferably less than 6nm, the deposited metallic silver forming at least one island-like film or discontinuous layer (ii') comprising or consisting of metallic silver,
-depositing at least one compound, preferably silicon oxide, titanium oxide or zirconium oxide, on the outermost surface of the stacked layers and/or on the outermost surface of the discontinuous layer (ii'), preferably by evaporation, further preferably by evaporation with the aid of an ion beam, and
-optionally applying the at least one coating (iii) to the outermost stacked layer of the anti-reflective coating or the mirror coating.
Example 15: the method of any one of the preceding embodiments 10 through 14, wherein additionally or alternatively
The at least two individual atoms comprise or consist of metallic copper, and/or
The at least two individual clusters comprise or consist of metallic copper.
I manufacture of ophthalmic lenses
Example 1:deposition of a hard-coated ophthalmic lens substrate comprising EP 2 578 649 A1, example 2 on the front surface of a substrate with SiO 2 And ZrO(s) 2 Scratch-resistant, antiviral, antistatic and anti-reflective coatings (AR) (-the rear surface of the ophthalmic lens substrate may comprise the same or different AR):
before starting deposition, the ophthalmic lens substrate is placed in a vacuum chamber evacuated to a pressure lower than 1E-4 mbar or 2E-5 mbar and then treated with ions from an built-in ion gun of the End-Hall type. The ion treatment is carried out at a pressure below 3E-3 mbar and at an energy between 80eV and 160eV and takes at least 40 seconds to 120 seconds.
Deposition of 3 ZrO by Electron Beam Gun (EBG) evaporation in an alternating manner 2 Layer and 3 SiO 2 AR stack of layers: depositing a first ZrO layer having a thickness of 3nm at a deposition rate of 0.3nm/s at an additional oxygen flow of 25sccm 2 A layer. Depositing a first SiO with a thickness of 80nm at a deposition rate of 1nm/s at an additional gas flow of 25sccm 2 A layer. Deposition at 0.45nm/s with an additional oxygen flow of 30sccmRate deposition of second ZrO with thickness of 33nm 2 A layer. Depositing a second SiO with a thickness of 15nm at a deposition rate of 0.8nm/s at an additional gas flow of 20sccm 2 A layer. Depositing a third ZrO layer having a thickness of 87nm at a deposition rate of 0.45nm/s with an additional oxygen flow of 30sccm 2 A layer. Depositing a third SiO with a thickness of 81nm at a deposition rate of 1nm/s at an additional gas flow of 25sccm 2 A layer.
Pure silver (99.9%) was deposited via EBG evaporation at a deposition rate of 0.02nm/s with oxygen ion assistance at an anode current of 1.2A and an anode voltage of 165V and an additional oxygen flow of 30 sccm. The nominal thickness for ending the deposition step is 1nm. Then, an additional SiO of 10nm was deposited at a deposition rate of 0.8nm/s with an additional gas flow of 20sccm 2 A layer. The deposition of a cleaning coating (Duralon, cotec GmbH) is then carried out by thermal evaporation.
Example 2:an antiviral coating without anti-reflective properties was deposited on the front surface of the ophthalmic lens substrate comprising the hard coating of EP 2 578 649 A1 (the back surface of the ophthalmic lens substrate may comprise the same or different antiviral coatings):
before starting deposition, the ophthalmic lens substrate is placed in a vacuum chamber evacuated to a pressure lower than 1E-4 mbar or 2E-5 mbar and then treated with ions from an built-in ion gun of the End-Hall type (Vivac MarkII+). The ion treatment is carried out at a pressure below 3E-3 mbar and at an energy between 80eV and 160eV and takes at least 40 seconds to 120 seconds.
Depositing a first SiO with a thickness of 80nm at a deposition rate of 1nm/s at an additional gas flow of 25sccm 2 A layer. Pure silver (99.9%) was deposited via EBG evaporation at a deposition rate of 0.03nm/s with oxygen ion assistance at an anode current of 1.2A and an anode voltage of 165V and an additional oxygen flow of 50 sccm. The nominal thickness for ending the deposition step was 1.7nm. Then, 5nm of additional SiO was deposited at a deposition rate of 0.8nm/s with an additional gas flow of 20sccm 2 A layer. The deposition of the cleaning coating (Duralon, cotai) is then carried out by thermal evaporation.
Example 3:deposition of a hard-coated ophthalmic lens substrate comprising EP 2 578 649 A1, example 2 on the front surface with ZrO 2 、SiO 2 And TiO 2 Scratch-resistant, antiviral, antistatic, and antireflective coatings (-the back surface of the ophthalmic lens substrate may include the same or different ARs):
before starting deposition, the ophthalmic lens substrate is placed in a vacuum chamber evacuated to a pressure lower than 1E-4 mbar or 2E-5 mbar and then treated with ions from an built-in ion gun of the End-Hall type (Vivac MarkII+). The ion treatment is carried out at a pressure below 3E-3 mbar and at an energy between 80eV and 160eV and takes at least 40 seconds to 120 seconds.
Deposition of a ZrO by Electron Beam Gun (EBG) evaporation in alternating mode using in part an end-hall type ion gun (Vivac MarkII+), deposition of ZrO 2 Layer and then 4 SiO 2 Layer and 3 TiO 2 AR stack of layers:
ZrO deposition at a deposition rate of 0.5nm/s at an additional gas flow of 35sccm to a thickness of 8nm 2 A layer.
Depositing a first SiO with a thickness of 219nm at a deposition rate of 1nm/s at an additional gas flow of 25sccm 2 A layer. Deposition of a first TiO 13nm thick at a deposition rate of 0.3nm/s with oxygen ion assistance at an ion gun anode current of 2.35A and an anode voltage of 135V 2 A layer. Depositing a second SiO with a thickness of 28nm at a deposition rate of 0.8nm/s at an additional gas flow of 20sccm 2 A layer. Depositing a second TiO having a thickness of 15nm at a deposition rate of 0.3nm/s with the assistance of oxygen ions at an ion gun anode current of 2.35A and an anode voltage of 135V 2 A layer. Depositing a third SiO with a thickness of 17nm at a deposition rate of 0.8nm/s at an additional gas flow of 20sccm 2 A layer. Depositing a third TiO 11nm thick at a deposition rate of 0.3nm/s with the assistance of oxygen ions at an ion gun anode current of 2.35A and an anode voltage of 135V 2 A layer. Depositing a fourth SiO with a thickness of 85nm at a deposition rate of 1nm/s at an additional gas flow of 25sccm 2 A layer.
At an anode current of 1.5A and an anode voltage of 135V and an additional oxygen flow of 25sccm,pure silver (99.9%) was deposited via EBG evaporation with the aid of oxygen ions at a deposition rate of 0.012 nm/s. The nominal thickness for ending the deposition step was 2.0nm. Then, 5nm of additional SiO was deposited at a deposition rate of 0.8nm/s with an additional gas flow of 20sccm 2 A layer. The deposition of the cleaning coating (Duralon, cotai) is then carried out by thermal evaporation.
Example 4:deposition of a hard-coated ophthalmic lens substrate comprising EP 2 578 649 A1, example 2 on the front surface of a substrate with SiO 2 And ZrO(s) 2 Scratch-resistant, antiviral, antistatic and anti-reflective coatings (AR) (-the rear surface of the ophthalmic lens substrate may comprise the same or different AR):
before starting deposition, the ophthalmic lens substrate is placed in a vacuum chamber evacuated to a pressure lower than 1E-4 mbar or 2E-5 mbar and then treated with ions from an built-in ion gun of the End-Hall type. The ion treatment is carried out at a pressure below 3E-3 mbar and at an energy between 80eV and 160eV and takes at least 40 seconds to 120 seconds.
Deposition of 3 ZrO by Electron Beam Gun (EBG) evaporation in an alternating manner 2 Layer and 3 SiO 2 AR stack of layers: depositing a first ZrO layer having a thickness of 3nm at a deposition rate of 0.3nm/s at an additional oxygen flow of 25sccm 2 A layer. Depositing a first SiO with a thickness of 80nm at a deposition rate of 1nm/s at an additional gas flow of 25sccm 2 A layer. Depositing a second ZrO layer having a thickness of 33nm at a deposition rate of 0.45nm/s at an additional oxygen flow of 30sccm 2 A layer. Depositing a second SiO with a thickness of 15nm at a deposition rate of 0.8nm/s at an additional gas flow of 20sccm 2 A layer. An antistatic ITO layer was deposited with a layer thickness of 6nm with the aid of argon ions from an ion gun at a deposition rate of 0.1 nm/s. The anode voltage was 160V and the anode current was 2.30A. Depositing a third ZrO layer having a thickness of 87nm at a deposition rate of 0.45nm/s with an additional oxygen flow of 30sccm 2 A layer. Depositing a third SiO with a thickness of 81nm at a deposition rate of 1nm/s at an additional gas flow of 25sccm 2 A layer.
At an anode current of 1.2A and an anode voltage of 165V and an additional oxygen flow of 30sccm, atPure silver (99.9%) was deposited via EBG evaporation with the assistance of oxygen ions at a deposition rate of 0.02 nm/s. The nominal thickness for ending the deposition step is 1nm. Then, an additional SiO of 10nm was deposited at a deposition rate of 0.8nm/s with an additional gas flow of 20sccm 2 A layer. The deposition of the cleaning coating (Duralon, cotai) is then carried out by thermal evaporation.
Example 5:deposition of a hard-coated ophthalmic lens substrate comprising EP 2 578 649 A1, example 2 on the front surface with ZrO 2 、SiO 2 And TiO 2 Scratch-resistant, antiviral, antistatic, and antireflective coatings (-the back surface of the ophthalmic lens substrate may include the same or different ARs):
before starting deposition, the ophthalmic lens substrate is placed in a vacuum chamber evacuated to a pressure lower than 1E-4 mbar or 2E-5 mbar and then treated with ions from an built-in ion gun of the End-Hall type (Vivac MarkII+). The ion treatment is carried out at a pressure below 3E-3 mbar and at an energy between 80eV and 160eV and takes at least 40 seconds to 120 seconds.
Deposition of a ZrO by Electron Beam Gun (EBG) evaporation in alternating mode using in part an end-hall type ion gun (Vivac MarkII+), deposition of ZrO 2 Layer and then 4 SiO 2 Layer and 3 TiO 2 AR stack of layers:
ZrO deposition at a deposition rate of 0.5nm/s at an additional gas flow of 35sccm to a thickness of 8nm 2 A layer.
Depositing a first SiO with a thickness of 219nm at a deposition rate of 1nm/s at an additional gas flow of 25sccm 2 A layer. Deposition of a first TiO 13nm thick at a deposition rate of 0.3nm/s with oxygen ion assistance at an ion gun anode current of 2.35A and an anode voltage of 135V 2 A layer. Depositing a second SiO with a thickness of 28nm at a deposition rate of 0.8nm/s at an additional gas flow of 20sccm 2 A layer. Depositing a second TiO having a thickness of 15nm at a deposition rate of 0.3nm/s with the assistance of oxygen ions at an ion gun anode current of 2.35A and an anode voltage of 135V 2 A layer. Depositing a third SiO with a thickness of 17nm at a deposition rate of 0.8nm/s at an additional gas flow of 20sccm 2 A layer. At the position ofAn antistatic ITO layer with a layer thickness of 6nm was deposited with the aid of argon ions at a deposition rate of 0.1 nm/s. Depositing a third TiO 11nm thick at a deposition rate of 0.3nm/s with the assistance of oxygen ions at an ion gun anode current of 2.35A and an anode voltage of 135V 2 A layer. Depositing a fourth SiO with a thickness of 85nm at a deposition rate of 1nm/s at an additional gas flow of 25sccm 2 A layer.
Pure silver (99.9%) was deposited via EBG evaporation at a deposition rate of 0.012nm/s with oxygen ion assistance at an anode current of 1.5A and an anode voltage of 135V and an additional oxygen flow of 25 sccm. The nominal thickness for ending the deposition step was 2.0nm. Then, 5nm of additional SiO was deposited at a deposition rate of 0.8nm/s with an additional gas flow of 20sccm 2 A layer. The deposition of the cleaning coating (Duralon, cotai) is then carried out by thermal evaporation.
II characterization of ophthalmic lenses according to examples
1. Measurement of transmittance and reflectance and calculation of absorbance:
some biocidal components (e.g., ag, cu, …) exhibit absorption characteristics. Using the transmittance and reflectance measurements (preferably Hunterlab UltraScan PRO), the light absorbance may be measured, for example, by using the following sequence:
i. uncoated lenses: measuring luminescence T 0
Uncoated lenses: measuring luminescence R 0
Calculation of luminescence A ref ＝1-R 0 -T 0
Depositing a coating comprising a biocidal component. Coated ophthalmic lenses were measured with Hunterlab.
v. coated lenses: measuring luminescence T 1
Coated lenses: measuring luminescence R 1
Measuring luminescence A Coating layer ＝1-R 1 -T 1 -A ref
Using the procedure described above, the following typical absorption rates of the above examples were measured on the first day after deposition:
| example 1 | LumA<1.5％ |
| Example 2 | LumA<2.5％ |
| Example 3 | LumA<3.0％ |
2. Silver quantification by energy dispersive X-ray analysis (EDX):
relative quantification of Ag content was performed on one side of the ophthalmic lens by EDX using the "fingerprinting" method: an acceleration voltage of 10kV was used, as well as a fixed sample geometry, sample position during measurement and working distance (distance between sample and electron beam optics). A set of fixed elements was chosen for evaluation of biocide content-here for the example of Ag: C. o, F, si, ti, zr, ag, in. These parameters were not changed to compare biocide content of different samples with each other.
Using the procedure described above, the following EDX Ag-content ranges for the above examples were measured:
| example 1 | 0.08at％…0.12at％ |
| Example 2 | 0.16at％…0.20at％ |
| Example 3 | 0.14at％…0.18at％ |
3. Rutherford backscattering spectrometry
This technique was used to quantify the Ag content of the ophthalmic lenses according to example 3:
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4. silver localization by GD-OES and TOF-SIMS
Glow discharge emission spectrometry (apparatus: spektromua GDA 550 HR) and time-of-flight secondary ion mass spectrometry (Iontof TOF-SIMS M6) have been used to study the relative amounts of Ag in the anti-reflective stacks of examples 1, 3, 4 and 5. Both techniques analyze samples from the top of the coating (clean coating) to the hard coating or ophthalmic lens substrate by sequentially and alternately sputtering very thin layers of only a few nanometers and then analyzing the sputtered material by light emission from the glow discharge plasma (GD-OES) used, or by analyzing the sputtered material with a mass spectrometer (TOF-SIMS). The result of both techniques is a depth profile that can at least give a relative concentration change of an element (e.g., ag).
Typical GD-OES results for depth distribution according to example 1:
outermost SiO deposited after Ag 2 On the layer, the Ag content is the third SiO according to example 1 2 Layers 2 to 10 times.
-at a third ZrO 2 Layer and third SiO 2 Around the interface between the layers, the Ag content is the third SiO according to example 1 2 Layers 1 to 5 times.
-at the second ZrO 2 Layer and second SiO 2 Interfacial circumference between layersThe Ag content is the third SiO according to example 1 2 Layers 1 to 5 times.
For the first SiO 2 Layer and first ZrO 2 Layer and deeper (hard coat or ophthalmic lens base), ag content is third SiO according to example 1 2 2 times or less the layer.
Typical GD-OES results for depth distribution according to example 3:
outermost SiO deposited after Ag 2 On the layer, the Ag content is the fourth SiO according to example 3 2 Layers 2 to 15 times.
-at all TiO 2 The Ag content in the layer is the fourth SiO according to example 3 2 1.5 to 5 times the layer.
In all other layers, the Ag content is the third SiO according to example 3 2 2 times or less the layer.
Typical TOF-SIMS results of depth distribution according to example 3:
outermost SiO deposited after Ag 2 On the layer, ag content is relative to TiO 2 The Ag content in the layer is within plus/minus one order of magnitude.
All TiO 2 The difference in Ag content between layers is less than 2 orders of magnitude.
As Zr and Ag cannot be separated in the mass spectrometer → it is impossible to interpret ZrO 2 Ag content in the layer
Ag content relative to TiO in all other or deeper layers 2 The Ag content in the layer is at least 1 order of magnitude lower
TOF-SIMS is sensitive to matrix effects (measurement of substances (e.g. Ag) depends on surrounding matrix (e.g. SiO) 2 Relative TiO 2 )。
5. Silver localization by TEM/S-TEM and EDX
A cross section of an ophthalmic lens according to example 3 was prepared by cutting two ophthalmic lenses and bonding them together in a face-to-face orientation. The assembly was wedge polished to a thickness of 20 μm. The sample is then treated with a broadband ion mill until the desired thickness in the range of 20 to 150nm is reached. The cross section of the ophthalmic lens according to example 3 was then studied by scanning transmission electron microscopy (S-TEM) and energy dispersive X-ray spectroscopy (EDX) mapping.
Representative features of the ophthalmic lenses according to example 3 in section S-TEM/EDX analysis are:
ag clusters can be seen in the whole stack
-in TiO 2 Larger individual clusters up to 10nm in size can be seen in the layer or in the surface layer.
-at SiO 2 Smaller clusters up to 5nm can be seen in the layer
SiO without visible clusters is also present 2 Layer, but according to EDX, at SiO 2 Resolving Ag in the matrix
According to EDX, ag content in TiO 2 Highest in the layer, and at SiO 2 Lowest of the layers
Non-occluded Ag layer
5. Antiviral efficacy
Antiviral properties were tested closely according to ISO 21702:2019 (E). The lens must be a flat piece without any curvature. As a preparation before testing, the lens surface needs to be sterilized with an antimicrobial solution and dried. After drying, the lenses were treated with a virus-containing solution and 20mm x 20mm areas were covered with a thin inorganic glass cover plate. The lenses were stored for 24 hours at >90% relative humidity and a temperature of 20 ℃ to 25 ℃. During this time, all or most of the viral population will die for the biocidal treated lenses. The solution was then retrieved from the lens and provided to vero cells where the surviving viral population was promoted to grow for an additional 24 hours. Analysis of antiviral efficacy was performed by fluorescence microscopy and flow cytometry, and the results were compared to non-biocidal control samples.
After 24 hours, antiviral efficacy was determined by comparing the coated test samples to reference (uncoated biocide) samples.
Examples 2 and 3 exhibited >99% antiviral efficacy when tested using the procedure described above.
Claims (89)
1. An ophthalmic lens comprising at least one coating,
it is characterized in that the method comprises the steps of,
at least one of the group consisting of:
at least two individual atoms of at least one biocidal component are located at least partially on top of the outermost surface of the at least one coating,
at least two individual molecules of at least one biocidal component at least partially on top of the outermost surface of the at least one coating, and
at least two individual clusters of at least one biocidal component are located at least partially on top of the outermost surface of the at least one coating.
2. The ophthalmic lens according to claim 1, characterized in that it additionally comprises at least one outermost coating layer selected from at least one of the group consisting of:
at least one cleaning coating as the outermost coating of the ophthalmic lens,
at least one hydrophobic coating as the outermost coating of the ophthalmic lens,
at least one hydrophilic coating and, as the outermost coating of the ophthalmic lens
At least one anti-fog coating as the outermost coating of the ophthalmic lens.
3. The ophthalmic lens according to any one of the preceding claims, characterized in that the at least one coating is selected from at least one of the group consisting of:
At least one photochromic primer coating layer,
at least one photochromic coating layer which is provided on the substrate,
at least one primer coating layer, which is applied to the substrate,
at least one hard-coat layer of the coating composition,
at least one anti-reflection coating
-at least one specular coating.
4. The ophthalmic lens according to any one of the preceding claims, characterized in that the at least one biocidal component is selected from at least one of the group consisting of:
at least one metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal oxide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal hydroxide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal oxide hydrate, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal nitride, which metal comprises or consists of silver, copper, titanium, zinc and/or iron,
at least one metal oxynitride, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron, and
at least one metal sulfide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron.
5. The ophthalmic lens according to any one of the preceding claims, characterized in that the maximum dimension of the at least two individual clusters is within at least one of the following ranges:
a) Individual clusters have a maximum spread of less than 20nm,
b) Individual clusters have a maximum spread of less than 15nm,
c) Individual clusters have a maximum spread of less than 10nm,
d) Individual clusters have a maximum spread in the range of 0.5nm to 20nm,
e) Individual clusters have a maximum spread in the range of 0.5nm to 15nm,
f) Individual clusters have a maximum spread in the range of 0.5nm to 10nm,
g) Individual clusters have a maximum spread in the range of 1nm to 20nm,
h) Individual clusters have a maximum spread in the range of 1nm to 15nm,
i) Individual clusters have a maximum spread in the range of 1nm to 10 nm.
6. Ophthalmic lens according to any of the preceding claims 4 and 5, characterized in that the total content of the at least one metal comprising or consisting of silver is in the range from 0.05at% to 0.50at%, as determined via EDX mapping of a thin layer of approximately 50nm thickness of a cross section of one surface of the ophthalmic lens.
7. An ophthalmic lens comprising at least one coating,
characterized in that the at least one coating is at least one selected from the group consisting of:
-a stack comprising or consisting of at least two stacked layers, said stack comprising an outermost stacked layer, and
a stack comprising or consisting of at least two stacked layers, said stack comprising an outermost stacked layer,
and at least one of the group consisting of:
at least two individual atoms of at least one biocidal component are located at least partially on top of the outermost surface of the outermost stacked layers,
at least two individual molecules of at least one biocidal component are located at least partially on top of the outermost surface of the outermost stacked layers, and
at least two individual clusters of at least one biocidal component are at least partially located on top of the outermost surface of the outermost stacked layers.
8. Ophthalmic lens according to claim 7, characterized in that it additionally comprises at least one outermost coating layer selected from at least one of the group consisting of:
at least one cleaning coating as the outermost coating of the ophthalmic lens,
at least one hydrophobic coating as the outermost coating of the ophthalmic lens,
at least one hydrophilic coating and, as the outermost coating of the ophthalmic lens
At least one anti-fog coating as the outermost coating of the ophthalmic lens.
9. Ophthalmic lens according to any of the preceding claims 7 and 8, characterized in that it comprises an ophthalmic lens base material based on at least one of the following:
i. glass or
At least one thin glass and at least one thermoplastic hard resin or
At least one thin glass and at least one thermosetting hard resin.
10. Ophthalmic lens according to claim 9, characterized in that the at least one anti-reflection coating comprises, starting from the uncoated or pre-coated surface of the ophthalmic lens substrate:
a)0.74131·λ 0 4.M to 0.89369.lambda. 0 /4·M；0.34275·λ 0 4-L to 0.41206-lambda 0 /4·L；0.54089·λ 0 4.M to 0.65207.lambda. 0 /4·M；0.70021·λ 0 4-L to 0.84181-lambda 0 /4·L；0.65779·λ 0 4.M to 0.79301.lambda. 0 /4·M；0.12950·λ 0 4.H to 0.16235.lambda 0 /4·H；0.49624·λ 0 4.M to 0.59825.lambda. 0 /4·M；0.28033·λ 0 4.H to 0.35143.lambda 0 /4·H；1.03563·λ 0 4-L to 1.24528-lambda 0 (4.L), wherein lambda 0 Selected from any wavelength in the range from 500nm to 600nm, M has a wavelength dependent refractive index in the range from 1.632 at 380nm to 1.599 at 780nm, or M has a wavelength dependent refractive index in the range from 1.750 at 380nm to 1.701 at 780nm, L has a wavelength dependent refractive index in the range from 1.473 at 380nm to 1.456 at 780nm, H preferably has a wavelength dependent refractive index in the range from 2.832 at 380nm to 2.270 at 780 nm; or (b)
b)0.64253·λ 0 4.M to 0.77461.lambda. 0 /4·M；0.29675·λ 0 4-L to 0.35676-lambda 0 /4·L；0.27260·λ 0 4.M to 0.32864.lambda. 0 /4·M；0.75891·λ 0 4-L to 0.91237-lambda 0 /4·L；0.90476·λ 0 4.M to 1.09075.lambda. 0 /4·M；0.10051·λ 0 4.H to 0.12600.lambda 0 /4·H；0.37747·λ 0 4.M to 0.45506.lambda. 0 /4·M；0.80453·λ 0 4-L to 0.96739-lambda 0 (4.L), wherein lambda 0 Selected from any wavelength in the range from 500nm to 600nm, M has a wavelength dependent refractive index in the range from 1.632 at 380nm to 1.599 at 780nm, or M has a wavelength dependent refractive index in the range from 1.750 at 380nm to 1.701 at 780nm, L has a wavelength dependent refractive index in the range from 1.473 at 380nm to 1.456 at 780nm, H preferably has a wavelength dependent refractive index in the range from 2.832 at 380nm to 2.270 at 780 nm; or (b)
c)0.19459·λ 0 4-L to 0.23394-lambda 0 /4·L；0.60931·λ 0 4.M to 0.73457.lambda. 0 /4·M；0.51278·λ 0 4-L to 0.61648-lambda 0 /4·L；0.45267·λ 0 4.M to 0.54573.lambda. 0 /4·M；0.48976·λ 0 4-L to 0.58880-lambda 0 /4·L；0.64177·λ 0 4.M to 0.77369.lambda. 0 /4·M；0.18388·λ 0 4.H to 0.23052.lambda 0 /4·H；0.50401·λ 0 4.M to 0.60762.lambda. 0 /4·M；0.31035·λ 0 4.H to 0.38910.lambda 0 /4·H；1.03965·λ 0 4-L to 1.25011-lambda 0 (4.L), wherein lambda 0 Selected from any wavelength in the range from 500nm to 600nm, M has a wavelength dependent refractive index in the range from 1.632 at 380nm to 1.599 at 780nm, or M has a wavelength dependent refractive index in the range from 1.750 at 380nm to 1.701 at 780nm, L has a wavelength dependent refractive index in the range from 1.473 at 380nm to 1.456 at 780nm, and H preferably has a wavelength dependent refractive index in the range from 2.832 at 380nm to 2.270 at 780 nm.
11. An ophthalmic lens comprising at least one coating, characterized by at least one of the group consisting of:
at least two individual atoms comprising or consisting of metallic silver are at least partially located on top of the outermost surface of the at least one coating, and
at least two individual clusters comprising or consisting of metallic silver are at least partially located on top of the outermost surface of the at least one coating.
12. Ophthalmic lens according to claim 11, characterized in that it additionally comprises at least one outermost coating layer selected from at least one of the group consisting of:
at least one cleaning coating as the outermost coating of the ophthalmic lens,
at least one hydrophobic coating as the outermost coating of the ophthalmic lens,
at least one hydrophilic coating and, as the outermost coating of the ophthalmic lens
At least one anti-fog coating as the outermost coating of the ophthalmic lens.
13. The ophthalmic lens according to any of the preceding claims 11 to 12, characterized in that the light transmittance (τ) of the ophthalmic lens in the faded state according to section 7.5.3.2 of ISO 8980-3:2013 (E) V0 ) Transmittance (τ) of the ophthalmic lens in darkened state with section 7.5.3.3 according to ISO 8980-3:2013 (E) V1 ) The variation between is within one of the following groups:
(A)τ V1 /τ V0 ≤0.95，
(B)τ V1 /τ V0 ≤0.98，
(C)0.95≤τ V1 /τ V0 ≤0.995，
(D)0.98≤τ V1 /τ V0 ≤0.995，
(E)0.985≤τ V1 /τ V0 ≤0.995。
14. a method for manufacturing an ophthalmic lens comprising an uncoated or pre-coated ophthalmic lens substrate and
(i) At least one of the layers of the coating,
(ii) At least one of the group consisting of:
at least two individual atoms of at least one biocidal component, said at least two individual atoms being located on top of the outermost surface of the at least one coating (i),
-at least two separate molecules of at least one biocidal component, said at least two separate molecules being located on top of the outermost surface of the at least one coating layer (i), and
at least two individual clusters of at least one biocidal component, said at least two individual clusters being located on top of the outermost surface of the at least one coating (i),
the method at least comprises the following steps:
applying or depositing the at least one coating (i) onto at least one uncoated or pre-coated surface of the ophthalmic lens substrate,
-depositing the at least one biocidal component on the outermost surface of the at least one coating (i).
15. A method for manufacturing an ophthalmic lens comprising an uncoated or pre-coated ophthalmic lens substrate and
(i) At least one of the layers of the coating,
(ii) At least one composite layer comprising at least one biocidal component,
the method at least comprises the following steps:
applying or depositing the at least one coating (i) onto at least one uncoated or pre-coated surface of the ophthalmic lens substrate,
depositing at least one biocidal component on the outermost surface of the at least one coating layer (i) thus forming at least one island-like film or discontinuous layer (ii') comprising or consisting of the at least one biocidal component,
-depositing at least one compound on the outermost surface of the at least one coating layer (i) and/or on the outermost surface of the at least one island film or discontinuous layer (ii').
16. The method according to claim 15, wherein the at least one island film or discontinuous layer (ii') comprises or consists of at least one selected from the group consisting of:
at least two separate atoms of at least one biocidal component,
at least two separate molecules of at least one biocidal component, and
at least two individual clusters of at least one biocidal component.
17. The method according to any of the preceding claims 15 and 16, characterized in that the at least one compound comprises or consists of at least one metal oxide selected from the group consisting of:
At least one silicon oxide is present in the form of a silicon oxide,
at least one titanium oxide, which is selected from the group consisting of titanium oxide,
at least one alumina, and
-at least one zirconia.
18. A method for manufacturing an ophthalmic lens comprising an uncoated ophthalmic lens substrate and
(i) At least one of the group consisting of:
two separate atoms of at least one biocidal component located on at least one of the uncoated surfaces of the ophthalmic lens substrate,
at least two separate molecules of at least one biocidal component located on at least one of the uncoated surfaces of the ophthalmic lens substrate, and
at least two individual clusters of at least one biocidal component located on at least one of the uncoated surfaces of the ophthalmic lens substrate,
(ii) At least one coating (i),
the method at least comprises the following steps:
depositing at least one biocidal component on at least one of the uncoated surfaces of the ophthalmic lens substrate, the deposited at least one biocidal component forming at least one island-like film or discontinuous layer (ii') comprising or consisting of said at least two individual atoms, said at least two individual molecules and/or said at least two individual clusters,
-applying the at least one coating (i) onto the uncoated surface of the ophthalmic lens substrate and/or onto the outermost surface of the at least one discontinuous layer (ii').
19. The method according to any of the preceding claims 14 to 18, characterized in that it comprises the additional step of:
-applying at least one coating (iii) -the at least one coating being selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating and at least one anti-fog coating-onto the outermost surface of:
a. the at least one coating (i) or (ii)
b. The at least one coating (i) and the at least one discontinuous layer (ii') or
c. The at least one composite layer (ii).
20. A method according to any one of the preceding claims 14 to 19, wherein the at least one biocidal component is deposited by evaporation.
21. A method according to any one of the preceding claims 14 to 20, wherein the at least one biocidal component is deposited by evaporation with the aid of an ion beam.
22. A method according to any one of the preceding claims 14 to 21, wherein the at least one biocidal component is deposited at a nominal layer thickness of less than 12 nm.
23. The method according to any of the preceding claims 14 to 22, characterized in that the at least one compound is deposited with a nominal layer thickness of less than 12 nm.
24. A method according to any one of the preceding claims 14 to 23, wherein the at least one biocidal component at least partially diffuses at least into the at least one coating (i).
25. The method according to any of the preceding claims 14 to 24, characterized in that the at least two individual clusters have a maximum spread within at least one of the following ranges:
a) Individual clusters have a maximum spread of less than 20nm,
b) Individual clusters have a maximum spread of less than 15nm,
c) Individual clusters have a maximum spread of less than 10nm,
d) Individual clusters have a maximum spread in the range of 1nm to 20nm,
e) Individual clusters have a maximum spread in the range of 1nm to 15nm,
f) Individual clusters have a maximum spread in the range of 1nm to 10nm,
g) Individual clusters have a maximum spread in the range of 0.5nm to 20nm,
h) Individual clusters have a maximum spread in the range of 0.5nm to 15nm,
i) Individual clusters have a maximum spread in the range of 0.5nm to 10 nm.
26. The method according to any of the preceding claims 14 to 25, characterized in that the at least one coating (i) is at least one selected from the group consisting of:
at least one photochromic primer coating layer,
At least one photochromic coating layer which is provided on the substrate,
at least one primer coating layer, which is applied to the substrate,
at least one hard-coat layer of the coating composition,
at least one anti-reflection coating
-at least one specular coating.
27. A method according to any one of the preceding claims 14 to 26, wherein the at least one biocidal component is selected from at least one of the group consisting of:
at least one metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal oxide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal hydroxide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal oxide hydrate, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal nitride, which metal comprises or consists of silver, copper, titanium, zinc and/or iron,
at least one metal oxynitride, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron, and
at least one metal sulfide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron.
28. A method according to any of the preceding claims 14-27, characterized in that the at least one biocidal component is selected from at least one metal comprising or consisting of silver, the at least one metal being set such that the optical transmittance (τ) of the ophthalmic lens in a faded state according to section 7.5.3.2 of ISO 8980-3:2013 (E) V0 ) Transmittance (τ) of the ophthalmic lens in darkened state with section 7.5.3.3 according to ISO 8980-3:2013 (E) V1 ) The variation between is within one of the following groups:
(A)τ V1 /τ V0 ≤0.95，
(B)τ V1 /τ V0 ≤0.98，
(C)0.95≤τ V1 /τ V0 ≤0.995，
(D)0.98≤τ V1 /τ V0 ≤0.995，
(E)0.985≤τ V1 /τ V0 ≤0.995。
29. a method according to any one of the preceding claims 14 to 28, characterized in that the at least one biocidal component is selected from at least one metal comprising or consisting of silver, and the total content of the at least one metal is in the range from 0.05at% to 0.50at%, as determined via EDX mapping of a thin layer of approximately 50nm thickness of the cross section of one surface of the ophthalmic lens.
30. A method for manufacturing an ophthalmic lens comprising an uncoated ophthalmic lens substrate and
(i) At least one composite layer comprising at least one biocidal component, the at least one composite layer being located on at least one of the uncoated surfaces of the ophthalmic lens substrate,
the method at least comprises the following steps:
depositing at least one biocidal component on an outermost surface of at least one of the uncoated surfaces of the ophthalmic lens substrate, the deposited at least one biocidal component forming at least one island film or discontinuous layer (ii'),
depositing at least one compound on the outermost surface of the uncoated surface of the ophthalmic lens substrate and/or on the outermost surface of the at least one island film or discontinuous layer (ii'),
31. The method according to claim 30, wherein the at least one island film or discontinuous layer (ii') comprises or consists of at least one selected from the group consisting of:
at least two separate atoms of the at least one biocidal component,
at least two separate molecules of at least one biocidal component, and
at least two individual clusters of at least one biocidal component.
32. The method according to any one of the preceding claims 30 and 31, wherein the at least one compound comprises or consists of at least one metal oxide selected from the group consisting of:
at least one silicon oxide is present in the form of a silicon oxide,
at least one titanium oxide, which is selected from the group consisting of titanium oxide,
at least one alumina, and
-at least one zirconia.
33. A method according to any one of the preceding claims 30 to 32, wherein the at least one biocidal component is selected from at least one of the group consisting of:
at least one metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal oxide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal hydroxide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
At least one metal oxide hydrate, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal nitride, which metal comprises or consists of silver, copper, titanium, zinc and/or iron,
at least one metal oxynitride, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron, and
at least one metal sulfide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron.
34. Method according to any of the preceding claims 30 to 33, characterized in that the method comprises at least the additional steps of:
-applying or depositing at least one coating (i) onto the outermost surface of the composite layer.
35. The method according to claim 34, wherein the at least one coating (i) is at least one selected from the group consisting of:
at least one photochromic primer coating layer,
at least one photochromic coating layer which is provided on the substrate,
at least one primer coating layer, which is applied to the substrate,
at least one hard-coat layer of the coating composition,
at least one anti-reflection coating
-at least one specular coating.
36. Method according to any of the preceding claims 30 to 35, characterized in that it comprises at least the additional steps of:
-applying at least one coating (iii) -the at least one coating being selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating and at least one anti-fog coating-onto the outermost surface of:
a. the at least one composite layer (ii) or
b. The at least one coating (i).
37. A method for manufacturing an ophthalmic lens comprising an uncoated or pre-coated ophthalmic lens substrate and
(i) At least one coating selected from at least one of the group consisting of:
-a stack comprising or consisting of at least two stacked layers, the stack comprising an outermost stacked layer, wherein at least one of the stacked layers comprises at least one biocidal component, and
a stack comprising or consisting of at least two stacked layers, the stack comprising an outermost stacked layer, wherein at least one of the stacked layers comprises at least one biocidal component,
the method at least comprises the following steps:
depositing at least one biocidal component on the outermost surface of at least one of the stacked layers,
-depositing at least one stack of layers of said anti-reflective coating or said specular coating.
38. A method according to claim 37, wherein the at least one biocidal component comprises or consists of:
a plurality of individual atoms of metallic silver and/or metallic copper,
-a plurality of individual clusters comprising or consisting of metallic silver and/or metallic copper.
39. Method according to any of the preceding claims 37 and 38, characterized in that the method comprises the additional step of:
-applying at least one coating (iii) selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating and at least one anti-fog coating onto the outermost surface of the anti-reflective coating or the mirror coating.
40. A method as claimed in any one of the preceding claims 37 and 39, wherein the at least one biocidal component is deposited at a nominal layer thickness of less than 12 nm.
41. The method according to any of the preceding claims 37 and 40, characterized in that the maximum size of each individual cluster is within at least one of the following ranges:
a) Individual clusters have a maximum spread of less than 20nm,
b) Individual clusters have a maximum spread of less than 15nm,
c) Individual clusters have a maximum spread of less than 10nm,
D) Individual clusters have a maximum spread in the range of 0.5nm to 20nm,
e) Individual clusters have a maximum spread in the range of 0.5nm to 15nm,
f) Individual clusters have a maximum spread in the range of 0.5nm to 10nm,
g) Individual clusters have a maximum spread in the range of 1nm to 20nm,
h) Individual clusters have a maximum spread in the range of 1nm to 15nm,
i) Individual clusters have a maximum spread in the range of 1nm to 10 nm.
42. The method according to any of the preceding claims 37 to 41, characterized in that the at least one biocidal component comprising individual metallic silver atoms and/or comprising individual clusters of metallic silver or consisting of metallic silver is set such that the light transmittance (τ) of the ophthalmic lens in the faded state according to section 7.5.3.2 of ISO 8980-3:2013 (E) V0 ) Transmittance (τ) of the ophthalmic lens in darkened state with section 7.5.3.3 according to ISO 8980-3:2013 (E) V1 ) The variation between is within one of the following groups:
(A)τ V1 /τ V0 ≤0.95，
(B)τ V1 /τ V0 ≤0.98，
(C)0.95≤τ V1 /τ V0 ≤0.995，
(D)0.98≤τ V1 /τ V0 ≤0.995，
(E)0.985≤τ V1 /τ V0 ≤0.995。
43. the method according to any of the preceding claims 14 to 42, characterized in that the content of the at least one biocidal component in the ophthalmic lens is set to kill more than or equal to 95% of enveloped viruses as measured according to ISO 21702:2019 (E) and/or more than or equal to 95% of bacteria as measured according to ISO 22196:2011 (E).
44. An ophthalmic lens comprising at least one coating,
it is characterized in that the method comprises the steps of,
at least one of the group consisting of:
at least two individual atoms of at least one biocidal component are located on top of the outermost surface of the at least one coating,
at least two separate molecules of at least one biocidal component are located on top of the outermost surface of the at least one coating, and
at least two individual clusters of at least one biocidal component are located on top of the outermost surface of the at least one coating.
45. The ophthalmic lens of claim 44 wherein the ophthalmic lens additionally comprises at least one outermost coating selected from at least one of the group consisting of:
at least one cleaning coating as the outermost coating of the ophthalmic lens,
at least one hydrophobic coating as the outermost coating of the ophthalmic lens,
at least one hydrophilic coating and, as the outermost coating of the ophthalmic lens
At least one anti-fog coating as the outermost coating of the ophthalmic lens.
46. The ophthalmic lens of any one of the preceding claims 44 and 45 wherein the at least one coating is selected from at least one of the group consisting of:
At least one photochromic primer coating layer,
at least one photochromic coating layer which is provided on the substrate,
at least one primer coating layer, which is applied to the substrate,
at least one hard-coat layer of the coating composition,
at least one anti-reflection coating
-at least one specular coating.
47. The ophthalmic lens of any one of the preceding claims 44 to 46 wherein the at least one biocidal component is selected from at least one of the group consisting of:
at least one metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal oxide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal hydroxide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal oxide hydrate, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal nitride, which metal comprises or consists of silver, copper, titanium, zinc and/or iron,
at least one metal oxynitride, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron, and
at least one metal sulfide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron.
48. The ophthalmic lens of any one of the preceding claims 44 to 47, wherein the maximum dimension of the at least two individual clusters is within at least one of the following ranges:
a) Individual clusters have a maximum spread of less than 20nm,
b) Individual clusters have a maximum spread of less than 15nm,
c) Individual clusters have a maximum spread of less than 10nm,
d) Individual clusters have a maximum spread in the range of 0.5nm to 20nm,
e) Individual clusters have a maximum spread in the range of 0.5nm to 15nm,
f) Individual clusters have a maximum spread in the range of 0.5nm to 10nm,
g) Individual clusters have a maximum spread in the range of 1nm to 20nm,
h) Individual clusters have a maximum spread in the range of 1nm to 15nm,
i) Individual clusters have a maximum spread in the range of 1nm to 10 nm.
49. The ophthalmic lens according to any one of the preceding claims 47 and 48, characterized in that the total content of the at least one silver-containing or silver-composed metal is in the range from 0.05at% to 0.50at%, as determined via EDX mapping of a thin layer of approximately 50nm thickness of a cross section of one surface of the ophthalmic lens.
50. An ophthalmic lens comprising at least one coating,
characterized in that the at least one coating is at least one selected from the group consisting of:
-a stack comprising or consisting of at least two stacked layers, said stack comprising an outermost stacked layer, and
a stack comprising or consisting of at least two stacked layers, said stack comprising an outermost stacked layer,
and at least one of the group consisting of:
at least two individual atoms of at least one biocidal component are located on top of the outermost surface of the outermost stacked layers,
at least two individual molecules of at least one biocidal component are located on top of the outermost surface of the outermost stacked layers, and
at least two individual clusters of at least one biocidal component are located on top of the outermost surface of the outermost stacked layers.
51. The ophthalmic lens of claim 50, additionally comprising at least one outermost coating layer selected from at least one of the group consisting of:
at least one cleaning coating as the outermost coating of the ophthalmic lens,
at least one hydrophobic coating as the outermost coating of the ophthalmic lens,
at least one hydrophilic coating and, as the outermost coating of the ophthalmic lens
At least one anti-fog coating as the outermost coating of the ophthalmic lens.
52. Ophthalmic lens according to any one of the preceding claims 50 and 51, characterized in that it comprises an ophthalmic lens base material based on at least one of the following:
i. glass or
At least one thin glass and at least one thermoplastic hard resin or
At least one thin glass and at least one thermosetting hard resin.
53. The ophthalmic lens of claim 52 wherein the at least one anti-reflection coating comprises, starting from an uncoated or pre-coated surface of the ophthalmic lens substrate:
a)0.74131·λ 0 4.M to 0.89369.lambda. 0 /4·M；0.34275·λ 0 4-L to 0.41206-lambda 0 /4·L；0.54089·λ 0 4.M to 0.65207.lambda. 0 /4·M；0.70021·λ 0 4-L to 0.84181-lambda 0 /4·L；0.65779·λ 0 4.M to 0.79301.lambda. 0 /4·M；0.12950·λ 0 4.H to 0.16235.lambda 0 /4·H；0.49624·λ 0 4.M to 0.59825.lambda. 0 /4·M；0.28033·λ 0 4.H to 0.35143.lambda 0 /4·H；1.03563·λ 0 4-L to 1.24528-lambda 0 (4.L), wherein lambda 0 Selected from any wavelength in the range from 500nm to 600nm, M has a wavelength dependent refractive index in the range from 1.632 at 380nm to 1.599 at 780nm, or M has a wavelength dependent refractive index in the range from 1.750 at 380nm to 1.701 at 780nm, L has a wavelength dependent refractive index in the range from 1.473 at 380nm to 1.456 at 780nm, H preferably has a wavelength dependent refractive index in the range from 2.832 at 380nm to 2.270 at 780 nm; or (b)
b)0.64253·λ 0 4.M to 0.77461.lambda. 0 /4·M；0.29675·λ 0 4-L to 0.35676-lambda 0 /4·L；0.27260·λ 0 4.M to 0.32864.lambda. 0 /4·M；0.75891·λ 0 4-L to 0.91237-lambda 0 /4·L；0.90476·λ 0 4.M to 1.09075.lambda. 0 /4·M；0.10051·λ 0 4.H to 0.12600.lambda 0 /4·H；0.37747·λ 0 4.M to 0.45506.lambda. 0 /4·M；0.80453·λ 0 4-L to 0.96739-lambda 0 (4.L), wherein lambda 0 Selected from any wavelength in the range from 500nm to 600nm, M has a wavelength dependent refractive index in the range from 1.632 at 380nm to 1.599 at 780nm, or M has a wavelength dependent refractive index in the range from 1.750 at 380nm to 1.701 at 780nm, L has a wavelength dependent refractive index in the range fromA wavelength dependent refractive index of 1.473 at 380nm to 1.456 at 780nm, H preferably has a wavelength dependent refractive index ranging from 2.832 at 380nm to 2.270 at 780 nm; or (b)
c)0.19459·λ 0 4-L to 0.23394-lambda 0 /4·L；0.60931·λ 0 4.M to 0.73457.lambda. 0 /4·M；0.51278·λ 0 4-L to 0.61648-lambda 0 /4·L；0.45267·λ 0 4.M to 0.54573.lambda. 0 /4·M；0.48976·λ 0 4-L to 0.58880-lambda 0 /4·L；0.64177·λ 0 4.M to 0.77369.lambda. 0 /4·M；0.18388·λ 0 4.H to 0.23052.lambda 0 /4·H；0.50401·λ 0 4.M to 0.60762.lambda. 0 /4·M；0.31035·λ 0 4.H to 0.38910.lambda 0 /4·H；1.03965·λ 0 4-L to 1.25011-lambda 0 (4.L), wherein lambda 0 Selected from any wavelength in the range from 500nm to 600nm, M has a wavelength dependent refractive index in the range from 1.632 at 380nm to 1.599 at 780nm, or M has a wavelength dependent refractive index in the range from 1.750 at 380nm to 1.701 at 780nm, L has a wavelength dependent refractive index in the range from 1.473 at 380nm to 1.456 at 780nm, and H preferably has a wavelength dependent refractive index in the range from 2.832 at 380nm to 2.270 at 780 nm.
54. An ophthalmic lens comprising at least one coating, characterized by at least one of the group consisting of:
at least two individual atoms comprising or consisting of metallic silver are located on top of the outermost surface of the at least one coating, and
at least two individual clusters comprising or consisting of metallic silver are located on top of the outermost surface of the at least one coating.
55. The ophthalmic lens of claim 54, additionally comprising at least one outermost coating layer selected from at least one of the group consisting of:
at least one cleaning coating as the outermost coating of the ophthalmic lens,
at least one hydrophobic coating as the outermost coating of the ophthalmic lens,
at least one hydrophilic coating and, as the outermost coating of the ophthalmic lens
At least one anti-fog coating as the outermost coating of the ophthalmic lens.
56. The ophthalmic lens according to any of the preceding claims 54 and 55, characterized in that the light transmittance (τ) of the ophthalmic lens in the faded state according to section 7.5.3.2 of ISO 8980-3:2013 (E) V0 ) Transmittance (τ) of the ophthalmic lens in darkened state with section 7.5.3.3 according to ISO 8980-3:2013 (E) V1 ) The variation between is within one of the following groups:
(A)τ V1 /τ V0 ≤0.95，
(B)τ V1 /τ V0 ≤0.98，
(C)0.95≤τ V1 /τ V0 ≤0.995，
(D)0.98≤τ V1 /τ V0 ≤0.995，
(E)0.985≤τ V1 /τ V0 ≤0.995。
57. the ophthalmic lens of claims 44-56 wherein the ophthalmic lens comprises an uncoated or pre-coated ophthalmic lens substrate.
58. The ophthalmic lens according to any one of the preceding claims 1 to 13 and 44 to 57, characterized in that the ophthalmic lens is in the form of computer readable instructions for its manufacture, said instructions being stored on a computer readable data carrier.
59. The ophthalmic lens according to any one of the preceding claims 1 to 13 and 44 to 57, characterized in that the ophthalmic lens is in the form of computer readable data, said data being stored on a computer readable data carrier.
60. The ophthalmic lens according to any one of the preceding claims 1 to 13 and 44 to 57, characterized in that the ophthalmic lens is in the form of computer readable instructions for its manufacture, said instructions being converted into data carrier signals.
61. The ophthalmic lens according to any of the preceding claims 1 to 13 and 44 to 57, characterized in that the ophthalmic lens is in the form of computer readable data, which data are converted into data carrier signals.
62. The ophthalmic lens according to any of the preceding claims 1 to 13 and 44 to 57, characterized in that the ophthalmic lens is in the form of a data carrier signal.
63. A digital data set describing an ophthalmic lens according to any one of the preceding claims 1 to 13 and 44 to 57.
64. A data carrier signal that converts a digital data set according to claim 63.
65. A data carrier storing a digital data set according to claim 63.
66. A method for manufacturing an ophthalmic lens comprising a coating, the method comprising at least the steps of:
applying or depositing a coating on at least one uncoated or pre-coated surface of the ophthalmic lens substrate,
-depositing at least one biocidal component on the outermost surface of the at least one coating.
67. A method for manufacturing an ophthalmic lens comprising a coating, the method comprising at least the steps of:
applying or depositing a coating on at least one uncoated or pre-coated surface of the ophthalmic lens substrate,
depositing at least one biocidal component on the outermost surface of said coating, thereby forming at least one island-like film or discontinuous layer comprising or consisting of the at least one biocidal component,
-depositing at least one compound on the outermost surface of the coating and/or on the outermost surface of the at least one island film or discontinuous layer.
68. The method of claim 67, wherein the at least one island film or discontinuous layer comprises or consists of at least one selected from the group consisting of:
at least two separate atoms of the at least one biocidal component,
at least two separate molecules of the at least one biocidal component, and
-at least two separate clusters of the at least one biocidal component.
69. The method according to any one of the preceding claims 67 and 68, wherein the at least one compound comprises or consists of at least one metal oxide selected from the group consisting of:
at least one silicon oxide is present in the form of a silicon oxide,
at least one titanium oxide, which is selected from the group consisting of titanium oxide,
at least one alumina, and
-at least one zirconia.
70. A method for manufacturing an ophthalmic lens comprising an uncoated ophthalmic lens substrate and a coating, the method comprising at least the steps of:
depositing at least one biocidal component on at least one of the uncoated surfaces of the ophthalmic lens substrate, the deposited at least one biocidal component forming at least one island-like film or discontinuous layer comprising or consisting of at least two individual atoms, said at least two individual molecules and/or said at least two individual clusters,
-applying a coating to the uncoated surface of the ophthalmic lens substrate and/or to the outermost surface of the at least one discontinuous layer.
71. The method according to any of the preceding claims 66 to 70, characterized in that the method comprises the additional step of:
-applying at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating and at least one anti-fog coating
-applied to the outermost surface of:
a. the at least one coating or
b. The at least one coating and the at least one discontinuous layer or
c. The at least one composite layer.
72. A method as claimed in any one of claims 66 to 71 wherein the at least one biocidal component is deposited by evaporation.
73. A method as claimed in any one of claims 66 to 72 wherein the at least one biocidal component is deposited by evaporation with the aid of an ion beam.
74. A method as claimed in any one of claims 66 to 73 wherein the at least one biocidal component is deposited at a nominal layer thickness of less than 12 nm.
75. The method of any one of the preceding claims 66 to 74, wherein the at least one compound is deposited at a nominal layer thickness of less than 12 nm.
76. A method as claimed in any one of claims 66 to 75 wherein the at least one biocidal component at least partially diffuses at least into the at least one coating.
77. The method of any one of the preceding claims 66 to 76, wherein the at least two individual clusters have a maximum spread within at least one of the following ranges:
a) Individual clusters have a maximum spread of less than 20nm,
b) Individual clusters have a maximum spread of less than 15nm,
c) Individual clusters have a maximum spread of less than 10nm,
d) Individual clusters have a maximum spread in the range of 1nm to 20nm,
e) Individual clusters have a maximum spread in the range of 1nm to 15nm,
f) Individual clusters have a maximum spread in the range of 1nm to 10nm,
g) Individual clusters have a maximum spread in the range of 0.5nm to 20nm,
h) Individual clusters have a maximum spread in the range of 0.5nm to 15nm,
i) Individual clusters have a maximum spread in the range of 0.5nm to 10 nm.
78. The method according to any one of the preceding claims 66 to 77, wherein the at least one coating is selected from at least one of the group consisting of:
at least one photochromic primer coating layer,
At least one photochromic coating layer which is provided on the substrate,
at least one primer coating layer, which is applied to the substrate,
at least one hard-coat layer of the coating composition,
at least one anti-reflection coating
-at least one specular coating.
79. A method according to any one of the preceding claims 66 to 78 wherein the at least one biocidal component is selected from at least one of the group consisting of:
at least one metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal oxide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal hydroxide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal oxide hydrate, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal nitride, which metal comprises or consists of silver, copper, titanium, zinc and/or iron,
at least one metal oxynitride, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron, and
at least one metal sulfide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron.
80. The method according to any of the foregoing claims 66-79, wherein the at least one biocidal component is selected from at least one metal comprising or consisting of silver, the at least one metal being set such that the optical transmittance (τ) of the ophthalmic lens in the faded state according to section 7.5.3.2 of ISO 8980-3:2013 (E) V0 ) Transmittance (τ) of the ophthalmic lens in darkened state with section 7.5.3.3 according to ISO 8980-3:2013 (E) V1 ) The variation between is within one of the following groups:
(A)τ V1 /τ V0 ≤0.95，
(B)τ V1 /τ V0 ≤0.98，
(C)0.95≤τ V1 /τ V0 ≤0.995，
(D)0.98≤τ V1 /τ V0 ≤0.995，
(E)0.985≤τ V1 /τ V0 ≤0.995。
81. a method according to any one of the preceding claims 66-80, characterized in that the at least one biocidal component is selected from at least one metal comprising or consisting of silver, and the total content of the at least one metal is in the range from 0.05at% to 0.50at%, as determined via EDX mapping of a thin layer of approximately 50nm thickness of the cross section of one surface of the ophthalmic lens.
82. A method for manufacturing an ophthalmic lens comprising an uncoated ophthalmic lens substrate and a coating, the method comprising at least the steps of:
depositing at least one biocidal component on an outermost surface of at least one of the uncoated surfaces of the ophthalmic lens substrate, the deposited at least one biocidal component forming at least one island-like film or discontinuous layer,
-depositing at least one compound on the outermost surface of the uncoated surface of the ophthalmic lens substrate and/or on the outermost surface of the at least one island film or discontinuous layer.
83. The method of claim 82, wherein the at least one island film or discontinuous layer comprises or consists of at least one selected from the group consisting of:
At least two separate atoms of the at least one biocidal component,
at least two separate molecules of at least one biocidal component, and
at least two individual clusters of at least one biocidal component.
84. The method according to any one of the preceding claims 82 and 83, wherein the at least one compound comprises or consists of at least one metal oxide selected from the group consisting of:
at least one silicon oxide is present in the form of a silicon oxide,
at least one titanium oxide, which is selected from the group consisting of titanium oxide,
at least one alumina, and
-at least one zirconia.
85. A method according to any one of the preceding claims 82 to 84, wherein the at least one biocidal component is selected from at least one of the group consisting of:
at least one metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal oxide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal hydroxide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
at least one metal oxide hydrate, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron,
At least one metal nitride, which metal comprises or consists of silver, copper, titanium, zinc and/or iron,
at least one metal oxynitride, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron, and
at least one metal sulfide, the metal comprising or consisting of silver, copper, titanium, zinc and/or iron.
86. The method according to any of the foregoing claims 82-85, characterised in that the method comprises at least the additional step of:
-applying or depositing at least one coating onto the outermost surface of the composite layer.
87. The method of claim 86, wherein the at least one coating is selected from at least one of the group consisting of:
at least one photochromic primer coating layer,
at least one photochromic coating layer which is provided on the substrate,
at least one primer coating layer, which is applied to the substrate,
at least one hard-coat layer of the coating composition,
at least one anti-reflection coating
-at least one specular coating.
88. The method according to any of the foregoing claims 82-87, characterised in that it comprises at least the additional steps of:
-applying at least one coating selected from the group consisting of at least one cleaning coating, at least one hydrophobic coating, at least one hydrophilic coating and at least one anti-fog coating
-applied to the outermost surface of:
a. the at least one composite layer or
b. The at least one coating.
89. The method according to any one of the preceding claims 66 to 94, wherein the content of the at least one biocidal component in the ophthalmic lens is set to kill ≡95% of enveloped viruses as measured according to ISO 21702:2019 (E) and/or to kill ≡95% of bacteria as measured according to ISO 22196:2011 (E).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2021/081826 WO2022193292A1 (en) | 2021-03-19 | 2021-03-19 | Spectacle lens with antibacterial and/or antiviral properties and method for manufacturing the same |
| CNPCT/CN2021/081826 | 2021-03-19 | ||
| PCT/EP2022/057254 WO2022195121A1 (en) | 2021-03-19 | 2022-03-18 | Spectacle lens with antibacterial and/or antiviral properties and method for manufacturing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117440755A true CN117440755A (en) | 2024-01-23 |
Family
ID=75302194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280035951.5A Pending CN117440755A (en) | 2021-03-19 | 2022-03-18 | Ophthalmic lens with antibacterial and/or antiviral properties and method for manufacturing same |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN117440755A (en) |
| BR (1) | BR112023019072A2 (en) |
| WO (2) | WO2022193292A1 (en) |
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- 2021-03-19 WO PCT/CN2021/081826 patent/WO2022193292A1/en active Application Filing
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- 2022-03-18 WO PCT/EP2022/057254 patent/WO2022195121A1/en active Application Filing
- 2022-03-18 CN CN202280035951.5A patent/CN117440755A/en active Pending
- 2022-03-18 BR BR112023019072A patent/BR112023019072A2/en unknown
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|---|---|
| BR112023019072A2 (en) | 2023-12-05 |
| WO2022193292A1 (en) | 2022-09-22 |
| WO2022195121A1 (en) | 2022-09-22 |
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