CN117426376A - Pesticide nanosuspension based on melt emulsification dispersion method - Google Patents
Pesticide nanosuspension based on melt emulsification dispersion method Download PDFInfo
- Publication number
- CN117426376A CN117426376A CN202311492638.7A CN202311492638A CN117426376A CN 117426376 A CN117426376 A CN 117426376A CN 202311492638 A CN202311492638 A CN 202311492638A CN 117426376 A CN117426376 A CN 117426376A
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- CN
- China
- Prior art keywords
- pesticide
- agent
- nanosuspension
- phase
- emulsification dispersion
- Prior art date
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- Pending
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- 239000000575 pesticide Substances 0.000 title claims abstract description 79
- 239000006070 nanosuspension Substances 0.000 title claims abstract description 68
- 239000006185 dispersion Substances 0.000 title claims abstract description 45
- 238000004945 emulsification Methods 0.000 title claims abstract description 38
- 238000000034 method Methods 0.000 title claims abstract description 36
- 239000002270 dispersing agent Substances 0.000 claims abstract description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 30
- 239000002245 particle Substances 0.000 claims abstract description 28
- 239000000155 melt Substances 0.000 claims abstract description 24
- 239000002562 thickening agent Substances 0.000 claims abstract description 24
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- 239000000080 wetting agent Substances 0.000 claims abstract description 12
- 239000003755 preservative agent Substances 0.000 claims abstract description 10
- 230000002335 preservative effect Effects 0.000 claims abstract description 10
- 239000002518 antifoaming agent Substances 0.000 claims abstract description 8
- 239000000839 emulsion Substances 0.000 claims description 38
- -1 alkyl glycoside Chemical class 0.000 claims description 23
- 238000003756 stirring Methods 0.000 claims description 21
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 21
- 230000001804 emulsifying effect Effects 0.000 claims description 20
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 17
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 17
- 238000002844 melting Methods 0.000 claims description 13
- 230000008018 melting Effects 0.000 claims description 13
- 229910019142 PO4 Inorganic materials 0.000 claims description 11
- 238000001816 cooling Methods 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 11
- 239000010452 phosphate Substances 0.000 claims description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 10
- 239000003945 anionic surfactant Substances 0.000 claims description 10
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 9
- 125000000129 anionic group Chemical group 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 150000002191 fatty alcohols Chemical class 0.000 claims description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 5
- 239000004359 castor oil Substances 0.000 claims description 5
- 235000019438 castor oil Nutrition 0.000 claims description 5
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 5
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000002091 cationic group Chemical group 0.000 claims description 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 4
- 239000000194 fatty acid Substances 0.000 claims description 4
- 229930195729 fatty acid Natural products 0.000 claims description 4
- 229920005615 natural polymer Polymers 0.000 claims description 4
- 239000002736 nonionic surfactant Substances 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 229920001059 synthetic polymer Polymers 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 3
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims description 3
- 229920001400 block copolymer Polymers 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- 229920001451 polypropylene glycol Polymers 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- SQAINHDHICKHLX-UHFFFAOYSA-N 1-naphthaldehyde Chemical group C1=CC=C2C(C=O)=CC=CC2=C1 SQAINHDHICKHLX-UHFFFAOYSA-N 0.000 claims description 2
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims description 2
- 229920002101 Chitin Polymers 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- 239000004166 Lanolin Substances 0.000 claims description 2
- 229920001732 Lignosulfonate Polymers 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- 125000005233 alkylalcohol group Chemical group 0.000 claims description 2
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims description 2
- 229940009868 aluminum magnesium silicate Drugs 0.000 claims description 2
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 2
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 claims description 2
- 150000004945 aromatic hydrocarbons Chemical class 0.000 claims description 2
- 239000003899 bactericide agent Substances 0.000 claims description 2
- 239000000440 bentonite Substances 0.000 claims description 2
- 229910000278 bentonite Inorganic materials 0.000 claims description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- 150000007942 carboxylates Chemical class 0.000 claims description 2
- 229920003086 cellulose ether Polymers 0.000 claims description 2
- 239000013530 defoamer Substances 0.000 claims description 2
- 150000002193 fatty amides Chemical class 0.000 claims description 2
- 229930182470 glycoside Natural products 0.000 claims description 2
- 239000000665 guar gum Substances 0.000 claims description 2
- 235000010417 guar gum Nutrition 0.000 claims description 2
- 229960002154 guar gum Drugs 0.000 claims description 2
- 230000002363 herbicidal effect Effects 0.000 claims description 2
- 239000004009 herbicide Substances 0.000 claims description 2
- 235000019388 lanolin Nutrition 0.000 claims description 2
- 229940039717 lanolin Drugs 0.000 claims description 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims description 2
- 239000005648 plant growth regulator Substances 0.000 claims description 2
- 229920002401 polyacrylamide Polymers 0.000 claims description 2
- 125000005575 polycyclic aromatic hydrocarbon group Chemical group 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 229940043266 rosin Drugs 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 235000010413 sodium alginate Nutrition 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 239000001384 succinic acid Substances 0.000 claims description 2
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims description 2
- 229940104261 taurate Drugs 0.000 claims description 2
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- 230000000361 pesticidal effect Effects 0.000 claims 9
- 150000002148 esters Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 26
- 238000002360 preparation method Methods 0.000 abstract description 14
- 229940079593 drug Drugs 0.000 abstract description 10
- 239000007788 liquid Substances 0.000 abstract description 10
- 241000607479 Yersinia pestis Species 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 9
- 239000000725 suspension Substances 0.000 abstract description 6
- 239000003960 organic solvent Substances 0.000 abstract description 3
- 238000003892 spreading Methods 0.000 abstract description 3
- 230000007480 spreading Effects 0.000 abstract description 3
- 238000009736 wetting Methods 0.000 abstract description 3
- 239000012876 carrier material Substances 0.000 abstract description 2
- 238000004090 dissolution Methods 0.000 abstract description 2
- 238000003912 environmental pollution Methods 0.000 abstract description 2
- 238000011068 loading method Methods 0.000 abstract description 2
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- 238000010008 shearing Methods 0.000 description 22
- ZXQYGBMAQZUVMI-UNOMPAQXSA-N cyhalothrin Chemical compound CC1(C)C(\C=C(/Cl)C(F)(F)F)C1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-UNOMPAQXSA-N 0.000 description 15
- 239000005874 Bifenthrin Substances 0.000 description 11
- OMFRMAHOUUJSGP-IRHGGOMRSA-N bifenthrin Chemical compound C1=CC=C(C=2C=CC=CC=2)C(C)=C1COC(=O)[C@@H]1[C@H](\C=C(/Cl)C(F)(F)F)C1(C)C OMFRMAHOUUJSGP-IRHGGOMRSA-N 0.000 description 11
- 239000008367 deionised water Substances 0.000 description 11
- 229910021641 deionized water Inorganic materials 0.000 description 11
- 238000012512 characterization method Methods 0.000 description 10
- 238000005303 weighing Methods 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 6
- ZXQYGBMAQZUVMI-RDDWSQKMSA-N (1S)-cis-(alphaR)-cyhalothrin Chemical compound CC1(C)[C@H](\C=C(/Cl)C(F)(F)F)[C@@H]1C(=O)O[C@@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-RDDWSQKMSA-N 0.000 description 5
- 241000238631 Hexapoda Species 0.000 description 5
- 239000005910 lambda-Cyhalothrin Substances 0.000 description 5
- 230000014759 maintenance of location Effects 0.000 description 5
- 239000003090 pesticide formulation Substances 0.000 description 5
- 240000007124 Brassica oleracea Species 0.000 description 4
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 4
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 4
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 4
- 240000008067 Cucumis sativus Species 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 239000000375 suspending agent Substances 0.000 description 4
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 241001124076 Aphididae Species 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- DAJSVUQLFFJUSX-UHFFFAOYSA-M sodium;dodecane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCS([O-])(=O)=O DAJSVUQLFFJUSX-UHFFFAOYSA-M 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 235000009849 Cucumis sativus Nutrition 0.000 description 1
- 241000209504 Poaceae Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000002888 effect on disease Effects 0.000 description 1
- 230000001999 effect on insects Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000007709 nanocrystallization Methods 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- RECVMTHOQWMYFX-UHFFFAOYSA-N oxygen(1+) dihydride Chemical compound [OH2+] RECVMTHOQWMYFX-UHFFFAOYSA-N 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000033458 reproduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 229940126589 solid medicine Drugs 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P7/00—Arthropodicides
- A01P7/02—Acaricides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P7/00—Arthropodicides
- A01P7/04—Insecticides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Insects & Arthropods (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Dispersion Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the technical field of pesticides, and discloses a pesticide nanosuspension based on a melt emulsification dispersion method, which comprises, by weight, 0.5-40 pesticide, 0.1-20 wetting agent, 0.1-20 dispersing agent, 0.1-6 thickening agent, 0.1-5 antifreezing agent, 0-2 antifoaming agent, 0-2 preservative, 0-1pH regulator and water; compared with the prior art, the nano suspension prepared based on the melt emulsification dispersion method can reduce the particle size of pesticide particles, increase the specific surface area of the pesticide particles, improve the dispersion performance and dissolution rate of the pesticide particles, enhance the spreading and wetting effects of the pesticide liquid on the surfaces of the blades, and further increase the control effect of the pesticide liquid on target pests in the blades in unit area; the pesticide nanometer suspension prepared by the method has stable physical properties, is convenient to store and transport, does not contain carrier materials, has high drug loading capacity and safety, does not contain organic solvents, reduces environmental pollution, and has simple and feasible preparation method and large-scale production.
Description
Technical Field
The invention relates to the technical field of pesticides, in particular to a pesticide nanosuspension based on a melt emulsification dispersion method.
Background
Pesticides are mainly used for preventing, eliminating or controlling diseases, insects, grasses and other harmful organisms which are harmful to agriculture and forestry, for purposefully regulating, controlling, influencing the chemical synthesis of plants and harmful organisms metabolism, growth, development, reproduction processes or from one or a mixture of substances derived from organisms, other natural products and produced by applying biotechnology, and preparations thereof. It is counted that the economic loss of agricultural products is up to $3000 hundred million through the prevention and treatment of insect pests by pesticides worldwide. However, most pesticides are poorly soluble in water and cannot be used directly, and they need to be processed into pesticide preparations for use. As an important pesticide formulation, the development of pesticide suspending agents presents a rapidly rising situation, and is increasingly favored by pesticide enterprises and pesticide users.
The current pesticide preparation processing gradually develops to the directions of safety, low toxicity and high efficiency, and the improvement of the effective utilization rate of pesticides and the reduction of residual pollution are the problems which need to be solved in the current pesticide formulation research. With development of nano technology, the pesticide is processed by the nano technology and nano materials, and the method becomes a hot spot for researching the current pesticide dosage form. The pesticide nanometer suspension is prepared by processing and improving the pesticide compound by a nanometer emulsification dispersion technology, so that the particle size of the pesticide particles is obviously reduced, the specific surface area of the pesticide particles is increased, the dissolution rate and the dispersibility of the pesticide are further improved, the problem that the water-added dispersibility of the insoluble pesticide is poor is solved, and the bioavailability of the pesticide is also improved. Meanwhile, the organic solvent and the carrier are eliminated, the toxicity is greatly reduced, and the use and the storage and transportation are safe and convenient.
The preparation technology of the melt emulsification dispersion is to mix the insoluble medicine with other components such as auxiliary agent, etc., melt and mix under the high temperature condition, emulsify and disperse to form a uniform mixture, cool and form a uniform emulsion. When the medicine is in a molten state, the particle size can be obviously reduced by the emulsification and dispersion effect under the condition of the existence of the surfactant, and the dispersibility of the medicine can be improved. Meanwhile, the abrasion of the melted medicine to the machine is greatly reduced compared with that of the solid medicine, the energy consumption is reduced, and the method is suitable for preparing the insoluble medicine nanosuspension with low melting point and good thermal stability.
Disclosure of Invention
The invention provides a pesticide nanosuspension based on a melt emulsification dispersion method, which comprises the following components in percentage by weight:
0.5-40 pesticide, 0.1-20 wetting agent, 0.1-20 dispersing agent, 0.1-6 thickening agent, 0.1-5 antifreezing agent, 0-2 defoamer, 0-2 preservative, 0-1pH regulator and water.
Further, the pesticide is one or more of a poorly soluble pesticide, a bactericide, a herbicide and a plant growth regulator;
and/or the wetting agent is one or more of nonionic surfactant, sulfonate anionic surfactant, phosphate anionic surfactant, carboxylate anionic surfactant and oligomeric surfactant;
and/or the dispersing agent is one or more of anionic dispersing agent, nonionic dispersing agent, anionic nonionic dispersing agent, high molecular dispersing agent and cationic dispersing agent;
and/or the thickener is one or more of an inorganic thickener, a natural polymer thickener and a synthetic polymer thickener;
and/or the antifreezing agent is one or more of ethylene glycol, propylene glycol, glycerol, polyethylene glycol, urea and sorbitol;
further, the nonionic surfactant is alkylphenol ethoxylates, fatty alcohol ethoxylates, fatty amine ethoxylates, alkyl glycosides, polyarylphenol ethoxylates, castor oil ethoxylates, polyoxyethylene fatty acid esters, ethylene oxide/propylene oxide block copolymers, sorbitol esters or polyglycerol fatty acid esters;
and/or the sulfonate anionic surfactant is alkylbenzenesulfonate, alpha-alkenyl sodium sulfonate, polyoxyethylene ether sulfate salt, polycyclic aromatic hydrocarbon formaldehyde condensate sulfonate or alkyl aromatic hydrocarbon sulfonate, sodium alkyl succinic acid sulfonate, polyoxyethylene ether monosuccinate sulfonate, fatty alcohol sulfate salt or fatty amide N-methyl taurate sodium salt;
and/or the phosphate anionic surfactant is polyoxyethylene ether phosphate, alkyl alcohol phosphate or alcohol ether carboxylate.
And/or the anionic dispersant is naphthalene formaldehyde condensate sulfonate, alkyl naphthalene formaldehyde condensate sulfonate or lignin sulfonate;
and/or the anionic non-ionic dispersant is phosphate dispersant, sulfate dispersant or succinate sulfonate;
and/or the nonionic dispersant is fatty alcohol polyoxypropylene polyoxyethylene ether or polyoxyethylene polypropylene ether segmented copolymer.
And/or the inorganic thickener is sodium chloride, ammonium sulfate, aluminum magnesium silicate, organic bentonite or organic magnesium aluminum silicate;
and/or the natural polymer thickener is cellulose ether, cationic guar gum, xanthan gum, chitin, sodium alginate, lanolin or rosin;
and/or the synthetic polymer thickener is polyvinylpyrrolidone, polyvinyl alcohol or polyacrylamide.
Further, the preparation method of the pesticide nanosuspension based on the melt emulsification dispersion method comprises the following steps:
and mixing the pesticide, the wetting agent, the dispersing agent, the thickening agent, the antifreezing agent, the defoaming agent, the preservative and the pH regulator, heating to a molten state, emulsifying and dispersing to obtain emulsion, stirring the emulsion, and cooling to normal temperature to obtain the pesticide nanosuspension.
Further, the mass and volume concentration of the pesticide is 0.5-40%; the mass volume concentration of the wetting agent is 0.1-20%; the mass volume concentration of the dispersing agent is 0.1-20%; the mass volume concentration of the thickener is 0.1-6%; the mass volume concentration of the antifreezing agent is 0.1-5%; the mass volume concentration of the defoaming agent is 0-2%; the mass volume concentration of the preservative is 0-2%; the mass volume concentration of the pH regulator is 0-1%.
Further, the preparation method of the pesticide nanosuspension based on the melt emulsification dispersion method comprises the following steps:
dispersing the pesticide in water, and heating to a molten state to obtain a phase A;
dissolving the wetting agent, the dispersing agent, the thickening agent, the antifreezing agent, the defoaming agent, the preservative and the pH regulator in water, and stirring to a transparent state to obtain a phase B;
and mixing the phase A and the phase B, emulsifying and dispersing to obtain emulsion, stirring the emulsion, and cooling to normal temperature to obtain the pesticide nanosuspension.
Further, the emulsion is obtained by mixing the phase A and the phase B and emulsifying and dispersing, specifically:
and (3) dropwise adding the phase B into the phase A under the conditions of melting temperature and emulsification and dispersion, and continuing to emulsify and disperse until the emulsion is uniform after the dropwise adding is finished.
Further, the melting temperature is greater than the melting point temperature of the pesticide.
Further, the particle size of the pesticide nanosuspension is 10-200nm.
Further, the shearing rate of the emulsifying dispersion is 1000-30000rpm/min, and the shearing time of the emulsifying dispersion is 0.05-1h;
and/or the stirring speed is 100-1000rpm/min.
The invention also provides a preparation method of any one of the pesticide nanosuspensions based on the melt emulsification dispersion method, which comprises the following steps:
dispersing the pesticide in water, and heating to a molten state to obtain a phase A;
dissolving the wetting agent, the dispersing agent, the thickening agent, the antifreezing agent, the defoaming agent, the preservative and the pH regulator in water, and stirring to a transparent state to obtain a phase B;
and mixing the phase A and the phase B, emulsifying and dispersing to obtain emulsion, stirring the emulsion, and cooling to normal temperature to obtain the pesticide nanosuspension.
Compared with the prior art, the beneficial effects of the method are as follows:
the invention provides a preparation method of a pesticide nanosuspension, which adopts an emulsifying dispersion preparation process under the condition of drug melting to form uniform emulsion with stable performance.
Controlling the particle size of the nanoparticles is an important difficulty in the preparation process, and too large or too small particle sizes may affect the release rate and effect of the pesticide. The medicine particles prepared by the invention have uniform size distribution, the average particle size is about 10-200nm, the specific surface area of the medicine particles is obviously improved, the contact area between the pesticide active component and the plant diseases and insect pests is enhanced, the control effect of the plant diseases and insect pests is increased, the use amount of the pesticide is reduced, and the environmental pollution is further reduced. Meanwhile, the application of the nano technology generally requires high cost and precise preparation technology, so that the production cost of the nano suspension is relatively high.
The pesticide nanometer suspension prepared by the melt emulsification dispersion method has the advantages of less consumption of surfactant, no use of organic solvent and carrier material, greatly reduced toxicity, and increased non-target biological safety, and can be used as an environment-friendly dosage form.
The pesticide nanometer suspension prepared by the melt emulsification dispersion method is uniformly and stably dispersed after being diluted by water, solves the problem of poor water solubility and dispersibility of the insoluble pesticide, obviously enhances the spreading and wetting effects of the liquid medicine on the surfaces of the blades, further improves the control effect of the liquid medicine on target pests, improves the bioavailability of the liquid medicine, and is an ideal dosage form superior to the suspension on the market.
The pesticide nano suspension prepared by the melt emulsification dispersion method has high pesticide compound content and high drug loading, and the preparation process is simple and can be used for amplifying the production process.
Drawings
FIG. 1 is a process flow diagram of a pesticide nanosuspension prepared in the present invention;
FIG. 2 is a scanning electron microscope characterization of a 5% lambda-cyhalothrin nanosuspension prepared in example 1 of the present invention;
FIG. 3 is a scanning electron microscope characterization of 10% lambda-cyhalothrin nanosuspension prepared in example 2 of the present invention;
FIG. 4 is a scanning electron microscope characterization of a 30% lambda-cyhalothrin nanosuspension prepared in example 3 of the present invention;
FIG. 5 is a scanning electron microscope characterization of a 10% bifenthrin nanosuspension prepared in example 4 of the present invention;
FIG. 6 is a scanning electron microscope characterization of 20% bifenthrin nanosuspension prepared in example 5 of the present invention.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Fig. 1 is a process flow diagram of a pesticide nanosuspension prepared in accordance with the present invention.
Example 1
The pesticide nanosuspension prepared in the embodiment is 5% efficient cyhalothrin nanosuspension, and comprises the following steps:
step 1: weighing 5g of high-efficiency cyhalothrin raw material, adding 80mL of deionized water, and heating to 80 ℃ in a water bath kettle to obtain a phase A;
step 2: weighing 0.6g of fatty alcohol polyoxyethylene ether, 0.1g of sodium dodecyl sulfonate and 0.1g of castor oil polyoxyethylene ether, dissolving in 14.2g of deionized water, and fully stirring to a transparent state to obtain a phase B;
step 3: dropping phase B into phase A at the shearing rate of 5000rpm in a high shearing dispersing emulsifying machine under the condition of 80 ℃ melting temperature;
step 4: after the dripping is completed, continuing to disperse and emulsify the emulsion by a high-shear dispersing and emulsifying machine until the emulsion is uniformly dispersed, wherein the shearing rate is 10000rpm, and the shearing time is 5min;
step 5: and taking out the emulsion after emulsification and dispersion, continuously stirring at the stirring speed of 300rpm, and cooling to normal temperature to obtain the 5% efficient cyhalothrin nanosuspension.
The invention prepares the high-efficiency cyhalothrin nano suspension with the concentration of 5 percent, the emulsion is uniform and stable, the particle size is about 50nm, and the characterization result of a scanning electron microscope is shown in figure 2.
Example 2
The pesticide nanosuspension prepared in the embodiment is 10% efficient cyhalothrin nanosuspension, and comprises the following steps:
step 1: weighing 10g of high-efficiency cyhalothrin raw material, adding 70mL of deionized water, and heating to 80 ℃ in a water bath kettle to obtain a phase A;
step 2: 1.2g of castor oil polyoxyethylene ether and 0.3g of fatty alcohol polyoxyethylene ether sodium sulfate are weighed and dissolved in 18.5g of deionized water, and are fully stirred to a transparent state to obtain a phase B;
step 3: dropping phase B into phase A at the shearing rate of 8000rpm in a high shearing dispersing emulsifying machine under the condition of 80 ℃ melting temperature;
step 4: after the dripping is completed, continuing to disperse and emulsify the emulsion by a high-shear dispersing and emulsifying machine until the emulsion is uniformly dispersed, wherein the shearing rate is 10000rpm, and the shearing time is 8min;
step 5: and taking out the emulsion after emulsification and dispersion, continuously stirring at the stirring speed of 500rpm, and cooling to normal temperature to obtain the 10% efficient cyhalothrin nanosuspension.
The invention prepares the high-efficiency cyhalothrin nano suspension with the concentration of 10 percent, the emulsion is uniform and stable, the particle size is about 100nm, and the characterization result of a scanning electron microscope is shown in figure 3.
Example 3
The pesticide nanosuspension prepared in the embodiment is a 30% efficient cyhalothrin nanosuspension, and comprises the following steps:
step 1: weighing 30g of high-efficiency cyhalothrin raw material, adding 50mL of deionized water, and heating to 80 ℃ in a water bath kettle to obtain a phase A;
step 2: 3g of alkylphenol formaldehyde resin polyoxyethylene ether, 2g of castor oil polyoxyethylene ether and 0.5g of sodium dodecyl sulfonate are weighed and dissolved in 14.5g of deionized water, and are fully stirred to a transparent state to obtain a phase B;
step 3: dropping phase B into phase A under the condition of 80 ℃ melting temperature and with the shearing rate of a high shearing dispersion emulsifying machine of 10000 rpm;
step 4: after the dripping is completed, continuing to disperse and emulsify the emulsion by a high-shear dispersing and emulsifying machine until the emulsion is uniformly dispersed, wherein the shearing rate is 12000rpm, and the shearing time is 10min;
step 5: and taking out the emulsion after emulsification and dispersion, continuously stirring at 600rpm, and cooling to normal temperature to obtain the 30% efficient cyhalothrin nanosuspension.
The invention prepares the high-efficiency cyhalothrin nano suspension with the concentration of 30 percent, the emulsion is uniform and stable, the particle size is about 150nm, and the characterization result of a scanning electron microscope is shown in figure 4.
Example 4
The pesticide nanosuspension prepared in the embodiment is a 10% bifenthrin nanosuspension, and comprises the following steps:
step 1: weighing 10g of bifenthrin raw medicine, adding 70mL of deionized water, and heating to 80 ℃ in a water bath kettle to obtain a phase A;
step 2: 2.0g of polyoxyethylene polypropylene ether segmented copolymer and 1.0g of polyoxyethylene ether phosphate are weighed and dissolved in 17.0g of deionized water, and are fully stirred to a transparent state to obtain a phase B;
step 3: dropping phase B into phase A at the shearing rate of 6000rpm in a high shearing dispersing emulsifying machine under the condition of 80 ℃ melting temperature;
step 4: after the dripping is completed, continuing to disperse and emulsify the emulsion by a high-shear dispersing and emulsifying machine until the emulsion is uniformly dispersed, wherein the shearing rate is 8000rpm, and the shearing time is 6min;
step 5: and taking out the emulsion after emulsification and dispersion, continuously stirring at 400rpm, and cooling to normal temperature to obtain the 10% bifenthrin nanosuspension.
The bifenthrin nanosuspension with the concentration of 10% is prepared, the emulsion is uniform and stable, the particle size is about 80nm, and the characterization result of a scanning electron microscope is shown in figure 5.
Example 5
The pesticide nanosuspension prepared in the embodiment is a 20% bifenthrin nanosuspension, and comprises the following steps:
step 1: weighing 20g of bifenthrin raw medicine, adding 60mL of deionized water, and heating to 80 ℃ in a water bath kettle to obtain a phase A;
step 2: 3.0g of ethylene oxide/propylene oxide block copolymer, 2.0g of fatty alcohol polyoxypropylene polyoxyethylene ether and 0.5g of polyoxyethylene ether monosuccinate sulfonate are weighed and dissolved in 14.5g of deionized water, and fully stirred to a transparent state to obtain a phase B;
step 3: dropping phase B into phase A under the condition of 80 ℃ melting temperature and with the shearing rate of a high shearing dispersion emulsifying machine of 10000 rpm;
step 4: after the dripping is completed, continuing to disperse and emulsify the emulsion by a high-shear dispersing and emulsifying machine until the emulsion is uniformly dispersed, wherein the shearing rate is 12000rpm, and the shearing time is 6min;
step 5: and taking out the emulsion after emulsification and dispersion, continuously stirring at the stirring speed of 500rpm, and cooling to normal temperature to obtain the 10% bifenthrin nanosuspension.
The bifenthrin nanosuspension with the concentration of 20% is prepared, the emulsion is uniform and stable, the particle size is about 120nm, and the characterization result of a scanning electron microscope is shown in figure 6.
Control group
The control group is a high-efficiency cyhalothrin suspending agent with the concentration content of 5% of the commercial drug.
The foliar retention experiment can examine the wettability of the nano suspension, and the evaluation of the adsorption and adhesion capability of the drug active substance on the hydrophilic/hydrophobic foliar is one of evaluation means for representing the effectiveness of the pesticide formulation.
In the leaf retention experiment, hydrophilic leaf surfaces are selected from cucumber leaf surfaces, and hydrophobic leaf surfaces are selected from cabbage leaf surfaces. Firstly, diluting the prepared pesticide suspension with water ion waterTo 0.1% (w/w), transferred to a beaker by ultrasonic vibration; then, fresh cucumber or cabbage leaves are collected, a punch is used to prepare regular leaves, and the leaf area S (cm) is measured 2 ) Soaking the blade in the liquid medicine for 15s, vertically taking out, suspending for 30s, weighing the mass M of the blade when the liquid drops no longer flow down 1 The method comprises the steps of carrying out a first treatment on the surface of the Finally, calculating the mass M of the blade before and after processing 0 And M 1 The average is taken by multiple measurements. The hold-up was calculated according to the following formula.
TABLE 1 retention of pesticide formulations on cucumber leaf surfaces
TABLE 2 retention of pesticide formulations on leaf surfaces of cabbage
As shown in table 1, table 2, the retention of the nanosuspensions prepared by the melt emulsification dispersion method on the leaf surfaces of cucumbers and cabbages was significantly lower than that of the control group, i.e., the nanosuspensions were more strongly adsorbed and adhered on the leaf surface area. After the drug particles are nanocrystallized, the particle size is obviously reduced, the number of drug-loaded particles per unit area is increased, the contact area of the particles and leaf surfaces is also increased, the spreading and wetting effects of the liquid medicine on the leaf surfaces are enhanced, and the control effect of the liquid medicine on target pests on the leaf surfaces per unit area is further improved.
Indoor biological Activity test
According to the standard of the "biological assay in pesticide Chamber" test guidelines (NY/T1154.10-2008). First, the nanosuspension and the experimental control group were diluted in equal ratio to 5 series of concentrations, each concentration repeated 4 times, with equal volumes of deionized water as controls. Feeding aphids as target pests in a constant temperature incubator, and finally counting eachAphid death number in each concentration gradient dish, and the semi-lethal concentration (LC 50 ) And its 95% confidence interval.
TABLE 3 determination of indoor biological Activity of lambda-cyhalothrin dosage form against aphids
As shown in Table 3, the LC of the lambda-cyhalothrin nanosuspensions at different concentrations in examples 1-3 50 LC of 5% higher efficient cyhalothrin suspending agent obviously lower than that of control group 50 At the same time, LC of bifenthrin nanosuspensions at different concentrations in examples 4-5 50 LC of 5% higher efficient cyhalothrin suspending agent obviously lower than that of control group 50 Namely, the nano suspension has better insecticidal effect. After the drug particles are subjected to nanocrystallization, the smaller the particle size is, the larger the specific surface area is, the adhesion of the drug particles on the leaf surfaces is increased, the detention performance of the drug particles on the leaf surfaces of crops is increased, the contact area with the surface of the crop pests is increased, and the active components are easier to act on biological targets. Meanwhile, the dispersion performance of the nano suspension is obviously enhanced, and the liquid medicine can be uniformly dispersed on the leaf surfaces of crops, so that the effectiveness of the preparation and the prevention and control effect on diseases and insect pests are improved.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. The pesticide nanosuspension based on the melt emulsification dispersion method is characterized by comprising the following components in percentage by weight:
0.5-40 pesticide, 0.1-20 wetting agent, 0.1-20 dispersing agent, 0.1-6 thickening agent, 0.1-5 antifreezing agent, 0-2 defoamer, 0-2 preservative, 0-1pH regulator and water.
2. The pesticidal nanosuspension based on the melt emulsification dispersion method according to claim 1, wherein the pesticide is one or more of a poorly soluble pesticide, a bactericide, a herbicide and a plant growth regulator;
and/or the wetting agent is one or more of nonionic surfactant, sulfonate anionic surfactant, phosphate anionic surfactant, carboxylate anionic surfactant and oligomeric surfactant;
and/or the dispersing agent is one or more of anionic dispersing agent, nonionic dispersing agent, anionic nonionic dispersing agent, high molecular dispersing agent and cationic dispersing agent;
and/or the thickener is one or more of an inorganic thickener, a natural polymer thickener and a synthetic polymer thickener;
and/or the antifreezing agent is one or more of ethylene glycol, propylene glycol, glycerol, polyethylene glycol, urea and sorbitol.
3. The pesticide nanosuspension based on the melt emulsification dispersion method according to claim 2, wherein the nonionic surfactant is alkylphenol ethoxylate, fatty alcohol ethoxylate, fatty amine ethoxylate, alkyl glycoside, polyarylphenol ethoxylate, castor oil ethoxylate, polyoxyethylene fatty acid ester, ethylene oxide/propylene oxide block copolymer, sorbitol ester ether or polyglycerin fatty acid ester;
and/or the sulfonate anionic surfactant is alkylbenzenesulfonate, alpha-alkenyl sodium sulfonate, polyoxyethylene ether sulfate salt, polycyclic aromatic hydrocarbon formaldehyde condensate sulfonate or alkyl aromatic hydrocarbon sulfonate, sodium alkyl succinic acid sulfonate, polyoxyethylene ether monosuccinate sulfonate, fatty alcohol sulfate salt or fatty amide N-methyl taurate sodium salt;
and/or the phosphate anionic surfactant is polyoxyethylene ether phosphate, alkyl alcohol phosphate or alcohol ether carboxylate;
and/or the anionic dispersant is naphthalene formaldehyde condensate sulfonate, alkyl naphthalene formaldehyde condensate sulfonate or lignin sulfonate;
and/or the anionic non-ionic dispersant is phosphate dispersant, sulfate dispersant or succinate sulfonate;
and/or the nonionic dispersant is fatty alcohol polyoxypropylene polyoxyethylene ether or polyoxyethylene polypropylene ether segmented copolymer;
and/or the inorganic thickener is sodium chloride, ammonium sulfate, aluminum magnesium silicate, organic bentonite or organic magnesium aluminum silicate;
and/or the natural polymer thickener is cellulose ether, cationic guar gum, xanthan gum, chitin, sodium alginate, lanolin or rosin;
and/or the synthetic polymer thickener is polyvinylpyrrolidone, polyvinyl alcohol or polyacrylamide.
4. The pesticidal nanosuspension based on the melt emulsification dispersion method according to claim 3, wherein the method for preparing the pesticidal nanosuspension based on the melt emulsification dispersion method is as follows:
and mixing the pesticide, the wetting agent, the dispersing agent, the thickening agent, the antifreezing agent, the defoaming agent, the preservative and the pH regulator, heating to a molten state, emulsifying and dispersing to obtain emulsion, stirring the emulsion, and cooling to normal temperature to obtain the pesticide nanosuspension.
5. The pesticidal nanosuspension based on the melt emulsification dispersion method according to claim 4, wherein the method for preparing the pesticidal nanosuspension based on the melt emulsification dispersion method is as follows:
dispersing the pesticide in water, and heating to a molten state to obtain a phase A;
dissolving the wetting agent, the dispersing agent, the thickening agent, the antifreezing agent, the defoaming agent, the preservative and the pH regulator in water, and stirring to a transparent state to obtain a phase B;
and mixing the phase A and the phase B, emulsifying and dispersing to obtain emulsion, stirring the emulsion, and cooling to normal temperature to obtain the pesticide nanosuspension.
6. The nano suspension of pesticide based on the melt emulsification dispersion method according to claim 5, wherein the mixing of the phase a and the phase B, and the emulsification dispersion are performed to obtain an emulsion, specifically:
and (3) dropwise adding the phase B into the phase A under the conditions of melting temperature and emulsification and dispersion, and continuing to emulsify and disperse until the emulsion is uniform after the dropwise adding is finished.
7. The pesticidal nanosuspension based on the melt emulsification dispersion method according to claim 6, wherein the melting temperature is greater than the melting point temperature of the pesticide.
8. The pesticidal nanosuspension based on the melt emulsification dispersion method according to claim 7, wherein the pesticidal nanosuspension has a particle size of 10 to 200nm.
9. The pesticidal nanosuspension based on the melt emulsification dispersion method according to claim 8, wherein the shear rate of the emulsification dispersion is 1000 to 30000rpm/min, and the shear time of the emulsification dispersion is 0.05 to 1h;
and/or the stirring speed is 100-1000rpm/min.
10. A method for preparing the pesticide nanosuspension based on the melt emulsification dispersion method as claimed in any one of claims 1 to 9, comprising:
dispersing the pesticide in water, and heating to a molten state to obtain a phase A;
dissolving the wetting agent, the dispersing agent, the thickening agent, the antifreezing agent, the defoaming agent, the preservative and the pH regulator in water, and stirring to a transparent state to obtain a phase B;
and mixing the phase A and the phase B, emulsifying and dispersing to obtain emulsion, stirring the emulsion, and cooling to normal temperature to obtain the pesticide nanosuspension.
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