CN117379057B - Multi-contact nerve electrode, manufacturing method thereof and nerve electrode monitoring structure - Google Patents
Multi-contact nerve electrode, manufacturing method thereof and nerve electrode monitoring structure Download PDFInfo
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- CN117379057B CN117379057B CN202311704850.5A CN202311704850A CN117379057B CN 117379057 B CN117379057 B CN 117379057B CN 202311704850 A CN202311704850 A CN 202311704850A CN 117379057 B CN117379057 B CN 117379057B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
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Abstract
The application relates to a multi-contact nerve electrode, a manufacturing method thereof and a nerve electrode monitoring structure, comprising the following steps: providing a flexible circuit laminate, wherein the flexible circuit laminate comprises an insulating substrate and a signal acquisition layer formed on the insulating substrate, and the signal acquisition layer comprises a plurality of electrode contacts arranged at intervals, conductive pins formed at the end part of the insulating substrate, and conductive circuits communicated between the conductive pins and the electrode contacts; and sequentially curling the flexible circuit board into a rod-shaped body along a preset direction, fixing to keep the shape of the rod-shaped body, and positioning the electrode contact and the conductive pin on the outer circumferential surface of the rod-shaped body to obtain the multi-contact nerve electrode. Electrode contacts, conductive pins and conductive circuits are formed on the insulating base material through a patterning treatment means, and then the insulating base material is curled into a rod shape and fixed in a shaping manner, so that the yield of conductive patterns can be ensured, and the nerve electrodes can be prepared in batches.
Description
Technical Field
The application relates to the technical field of nerve electrodes, in particular to a multi-contact nerve electrode, a nerve electrode monitoring structure and a manufacturing method thereof.
Background
The nerve electrode is a hot spot problem in neurological research and is a bridge connecting neurons with external electronic equipment, and through the nerve electrode, we can measure electrophysiological signals of cerebral cortex, including local field potential and action potential, which has great significance for development of brain science and diagnosis of brain diseases, such as epilepsy, parkinson's disease, alzheimer's disease and the like.
The prior art provides a method for manufacturing a nerve electrode, which comprises the following steps: providing a metal bar A, sleeving a tubular metal blank on the metal bar A, and manufacturing and forming a mask by using the metal bar A according to a design pattern; providing a cylindrical flexible middle-hole tubular structure, inserting a metal bar B into the inner side of the middle-hole tubular structure, and sleeving the mask plate on the outer side of the tubular structure; forming metal fine wires, contacts and bonding pads on the surface of the flexible mesoporous tubular structure by metal deposition in an evaporation manner; cutting a mask plate on the outer side of the tubular structure in a laser cutting mode; removing the metal bar B to obtain the nerve electrode.
Since the nerve electrode is required to be implanted into the brain with little damage, reduce rejection of brain tissue to the electrode, and have a high spatial-temporal resolution for nerve signal measurement, the diameter of the nerve electrode is generally in the order of millimeters, specifically, the diameter is generally required to be less than 2 millimeters, the width of the line is 10nm-1mm, and the diameter of the bonding pad is 1 μm-1mm, and the preparation method of the nerve electrode has the following defects: firstly, in the operation process, when j uses laser to cut a mask, the integrity of the metal pattern conducting layer is difficult to ensure, and the cutting can hurt a circuit to influence the acquisition of a sensing result; secondly, as the mask is very high in precision requirement and finally removed in a cutting mode, the mask is not reused, the manufacturing cost of the whole nerve electrode is definitely increased, and batch preparation of the nerve electrode is not realized; and secondly, as the length of the flexible mesoporous tubular structure for manufacturing the nerve electrode is 1-2 cm, the metal bar B on the inner side of the mesoporous tubular structure needs to be removed after the mask on the outer side of the tubular structure is cut, and the outer diameter of the metal bar B is just matched with the inner diameter of the flexible mesoporous tubular structure to ensure the positioning of the position of the flexible mesoporous tubular structure, the positioning of the position for forming the metal pattern conducting layer is realized, but the difficulty is increased for removing and stripping the metal pattern conducting layer at the step, and the metal pattern conducting layer is damaged by a little carelessness.
Therefore, it is necessary to provide a method for manufacturing a multi-contact nerve electrode capable of ensuring yield and mass-manufacturing the nerve electrode, and a multi-contact nerve electrode obtained by using the manufacturing method.
Disclosure of Invention
The multi-contact nerve electrode manufacturing method can ensure yield and can prepare nerve electrodes in batches, and the multi-contact nerve electrode and the nerve electrode monitoring structure obtained by the manufacturing method.
A method for manufacturing a multi-contact nerve electrode, comprising:
providing a flexible circuit laminate, wherein the flexible circuit laminate comprises an insulating substrate and a signal acquisition layer formed on the insulating substrate, and the signal acquisition layer comprises a plurality of electrode contacts arranged at intervals, conductive pins formed at the end part of the insulating substrate, and conductive circuits communicated between the conductive pins and the electrode contacts; and
the flexible wiring laminate is sequentially curled into a rod-like body in a predetermined direction, fixed to maintain the shape of the rod-like body, and the electrode contacts and the conductive pins are located on the outer circumferential surface of the rod-like body to obtain a multi-contact nerve electrode.
By adopting the technical scheme, the flexible circuit laminate is provided by a patterning technology, and then is curled into a rod shape in a curling mode and fixed in a shaping mode, so that the yield of the signal acquisition layer can be ensured, and the nerve electrode can be prepared in batches; the mask plate is also used in the flexible circuit laminate process, but the mask plate can be repeatedly used, so that the preparation cost of the nerve electrode can be reduced.
In this embodiment, a gap is formed between adjacent layers of the rod-shaped body, and after the insulating base material is curled into a rod shape, curable glue is injected into the gap from one end of the rod-shaped body, and the curable glue is cured; or (b)
The rod-shaped body is hollow cylinder-shaped, and curable glue is injected into the hollow cylinder-shaped body.
By adopting the technical scheme, the shape of the rod-shaped body is rapidly cured and shaped by the curable adhesive, and the multi-contact nerve electrode with stable shape can be obtained.
In this embodiment, the method further includes sleeving an electrode head on an end of the rod opposite to the conductive pin before injecting the curable adhesive into the rod.
Through adopting above-mentioned scheme, through the one end cover that is opposite at bar-shaped body and conductive pin establishes the electrode head, can avoid the colloid to influence the human body, the electrode head is the button head form moreover, can reduce the influence with the friction of contact position.
In this embodiment, the flexible circuit board is a single-layer circuit board or a multi-layer circuit board, and when the flexible circuit board is a multi-layer board, a conductive via hole is further formed in the flexible circuit board, the conductive circuit is disposed in an inner layer of the circuit board, and the electrode contact is electrically connected to the conductive pin through the conductive via hole and the conductive circuit; and/or
When the flexible circuit layer board is a multilayer board, the signal acquisition layer further comprises a plurality of temperature sensors, and the temperature sensors are arranged in one-to-one correspondence with the electrode contacts; and/or
The impedance of the conductive line is less than 50Ω.
By adopting the scheme, the positions of the electrode contacts and the conductive lines can be well laid out, and more layout contacts and conductive lines can be realized in the limited area of the insulating substrate.
In this embodiment, the electrode contacts are arranged in an array on the insulating substrate, and each electrode contact is connected with one conductive pin through one conductive line; and/or
Forming a metal guard layer over the electrode contacts and the conductive lines is also included after forming the conductive lines.
The metal protective layer is used for protecting the electrode contact and the conductive circuit from oxidation or erosion of water and oxygen so as to influence the quality of the nerve electrode.
In this embodiment, the rod-like body is flat or cylindrical.
Through adopting above-mentioned technical scheme, the rod-shaped body of this application is through curling formation to the shape of neural electrode can be decided according to actual demand, diversified application scenario has been realized.
In this embodiment, the diameter of the multi-contact nerve electrode is interposed between 0.6 and 2 millimeters.
By adopting the scheme, the nerve electrode is little damaged when implanted into the brain, the rejection reaction of brain tissue to the electrode is reduced, and the nerve electrode needs to have higher space-time resolution for nerve signal measurement.
In the application, a method for manufacturing the nerve electrode monitoring structure is also provided.
An electrode fabrication method of a nerve electrode monitoring structure, comprising:
providing the multi-contact nerve electrode manufactured and formed by the multi-contact nerve electrode manufacturing method; and
and a sleeve is sleeved on the rod-shaped body and is electrically connected with the flexible circuit board on the conductive pins, so that the sleeve protects the connection position of the flexible circuit board and the conductive pins to obtain the nerve electrode monitoring structure.
In this embodiment, a sleeve is sleeved on the multi-contact neural electrode and is electrically connected to the flexible circuit board on the conductive pins, so that the sleeve protects the position where the flexible circuit board is connected to the conductive pins. By adopting the scheme, the flexible circuit board is connected to the conductive pins, so that signals of the brain can be collected in real time; a sleeve is sleeved on the rod-shaped body, and a handheld position is provided when the electrode is implanted.
In one embodiment of the present application, a multi-contact neural electrode is also provided.
A multi-contact neural electrode, comprising:
a rod-shaped body formed by sequentially curling an insulating base material along a predetermined direction, the rod-shaped body comprising a first end and a second end which are opposite, the outer circumferential surface of the first end being formed with electrode contacts arranged in an array; and a conductive pin is formed on the outer circumferential surface of the second end, and the conductive pin is electrically connected with the electrode contact through a conductive circuit.
In this embodiment, the second end of the rod-shaped body is sleeved with an electrode head.
In this embodiment, the multi-contact nerve electrode is flat or cylindrical.
In summary, the present application includes at least one of the following beneficial technical effects:
1. the flexible circuit laminate prepared by the patterning treatment means comprises electrode contacts, conductive pins and conductive circuits, the flexible circuit laminate is curled into a rod shape by a curling mode, and finally the curled flexible circuit laminate is fixed by a glue injection mode, so that the yield of a signal acquisition layer can be ensured, and the nerve electrodes can be prepared in batches; the patterning means can reduce the internal resistance of the conductive line, thereby reducing the practical power.
2. The mask plate is also used in the flexible circuit board preparation process, and can be repeatedly utilized, so that the preparation cost of the nerve electrode can be reduced.
3. The rod-shaped body is formed by curling, so that the shape of the nerve electrode can be determined according to actual requirements, and diversified application scenes are realized.
4. By using the shape of the mask, the electrode contact for sensing brain signals, the temperature sensor for sensing the thermosetting area and the electrode contact for thermosetting can be formed at one time by etching technology, so that the manufacturing efficiency is higher.
Drawings
Fig. 1 is a cross-sectional view of a flexible circuit substrate provided in a first embodiment of the present application;
FIG. 2 is a cross-sectional view of forming a metal shield on the surface of an electrode contact, conductive pin;
FIG. 3 is a top view of FIG. 2;
FIG. 4 is a schematic view showing a state in which the layer structure of FIG. 3 is curled;
FIG. 5 is a schematic diagram of the structure of the layer structure of FIG. 3 curled to provide a rod;
FIG. 6 is a schematic view of a structure in which an electrode head is sleeved at one end of a rod-shaped body provided with an electrode contact;
FIG. 7 is a schematic cross-sectional view of a curable glue filled between the layer structures of the stick;
FIG. 8 is a schematic diagram of a structure in which a sleeve is sleeved on a multi-contact electrode and a flexible circuit board is connected to one end of a conductive pin to obtain a nerve electrode monitoring structure;
FIG. 9 is a top view of a patterning process for a metal layer on an insulating substrate according to a second embodiment of the present application;
FIG. 10 is a schematic illustration of crimping a patterned insulating substrate according to a third embodiment of the present disclosure;
fig. 11 is a schematic structural view of a flexible circuit board provided in a fourth embodiment of the present application.
Reference numerals illustrate: 100. a multi-contact neural electrode; 110. a neural electrode monitoring structure; 1. a flexible circuit laminate; 11. an insulating substrate; 13. a signal acquisition layer; 21. an electrode contact; 22. a conductive pin; 23. a conductive line; 3. a rod-like body; 31. an outer circumferential surface; 32. a gap; 4. a curable glue; 24. a metal protective layer; 25. a temperature sensor; 5. an electrode head; 6. a flexible circuit board; 7. a sleeve; 8. and (5) fixing the colloid.
Detailed Description
The method for manufacturing the multi-contact nerve electrode, the nerve electrode monitoring structure and the manufactured multi-contact nerve electrode provided by the application are further described in detail below with reference to fig. 1-11.
The application provides a manufacturing method of a multi-contact nerve electrode, and the multi-contact nerve electrode manufactured by the method is mainly characterized in that an electrode part is placed into the brain and is used in combination with a recording, monitoring and stimulating system to perform stereotactic electroencephalogram recording (SEEG), monitoring and short-time stimulation, so that the multi-contact nerve electrode is used for preoperative diagnosis of epileptic groups. The SEEG technique uses a minimally invasive method, does not need an operation incision, only needs 2mm of scalp and skull to drill micropores, and places the deep electrode in a specific position in the deep brain. Thus, the technique is suitable for epileptic patients requiring intracranial electrode electroencephalogram localization.
Example 1
Specifically, a method for manufacturing the multi-contact nerve electrode 100 includes:
s1: referring to fig. 1, a flexible circuit board 1 is provided, and the flexible circuit board 1 is a single-layer circuit board or a multi-layer circuit board. In the present embodiment, the flexible wiring laminate 1 is a single-layer board.
The flexible circuit board 1 comprises an insulating base material 11 and a signal acquisition layer 13 formed on the insulating base material 11.
The insulating substrate 11 may be polyurethane (TPU), polyimide (PI), polyurethane, polyethylene terephthalate (PET), or the like.
Referring to fig. 2-3, the signal acquisition layer 13 is formed by patterning techniques. The material of the signal acquisition layer 13 is a copper layer or a metal molybdenum layer, and the thickness of the metal molybdenum layer is 120nm-180nm in consideration of long-time contact between the electrode and the human body to avoid infection of the human body.
The signal acquisition layer 13 includes a plurality of electrode contacts 21, conductive pins 22 and conductive traces 23 arranged at intervals. Conductive traces 23 connect the conductive pins 22 with the electrode contacts 21.
In this embodiment, the number of the electrode contacts 21 may be 1 to 18, the width is 0.5mm to 1mm, and the arrangement pitch may be selected individually.
In this embodiment, the electrode contacts 21 are arranged in an array on the insulating substrate 11, and each electrode contact 21 is connected to one conductive pin 22 through one of the conductive traces 23. By this arrangement, the positions of the electrode contacts 21 and the conductive traces 23 can be well laid out, and more layout of the electrode contacts 21 and the conductive traces 23 can be realized within a limited area of the insulating substrate 11.
In this embodiment, the electrode contacts 21 may further include a thermal coagulation electrode contact, where the thermal coagulation contact is used for thermal coagulation and destruction, that is, irreversible destruction is formed by passing high-frequency current in human tissue to heat the human tissue itself and completely denature proteins in the human tissue when the temperature of the human tissue exceeds 46 ℃. The thermoelement electrode contact 21 uses two electrode points on the intracranial deep electrode implanted in the brain as two electrodes of the radio frequency energy output loop, so that brain tissue between the two points and in a certain range around the two points is heated and deformed, and the effect of thermoelement damage is achieved.
The impedance of the conductive trace 23 is less than 50Ω. At present, the traditional SEEG electrode adopts a metal filament, the wire internal impedance of the metal filament is 200 to 300 omega, so that higher power is required to be provided for heating and ablating the treated human tissue part during diagnosis and treatment, and the electrode is unstable and sometimes burns an internal cable. In the present embodiment, the conductive line 23 is formed by patterning, so that the line impedance can be greatly reduced, and the power can be reduced.
Referring to fig. 4, in the present embodiment, after forming the conductive line 23, a metal protection layer 24 is further formed on the electrode contact 21 and the conductive line 23. The metal shield 24 may be a gold layer, or an alloy layer of gold and nickel; or may be a metal layer of platinum, platinum iridium, platinum titanium, gold, silver, or the like. By adopting the above technical scheme, the electrode contact 21 and the conductive line 23 are protected by the metal protection layer 24, and oxidation or erosion of water and oxygen is prevented to influence the quality of the nerve electrode.
Of course, it is understood that in other manners, the conductive traces 23 and the conductive pins 22 may be encapsulated by an encapsulation layer.
S2: referring to fig. 2 to 5, the insulating base material 11 is curled into a rod-like body 3 with the electrode contacts 21 and the conductive leads 22 located on the outer circumferential surface 31 of the rod-like body 3. Electrode contacts 21 are for contacting the brain to sense signals from the brain, and conductive pins 22 are for connection to external circuitry.
The rod-shaped body 3 is formed by curling along a preset direction, so that the shape of the nerve electrode can be determined according to actual requirements, and various application scenes are realized. In the present embodiment, the rod 3 is flat or cylindrical.
S3: referring to fig. 6, an electrode cap 5 is sleeved on an end of the rod 3 opposite to the conductive pin 22. By sleeving the electrode head 5 at the end of the rod-shaped body 3 opposite to the conductive pin 22, the influence of the later-stage curable adhesive 4 on the human body can be avoided, and the electrode head 5 is round-headed, so that the influence of friction with a contact part can be reduced.
S4: referring to fig. 7, in the present embodiment, a gap 32 is formed between adjacent layers of the rod 3, and a curable adhesive 4 is injected into the gap 32 from one end of the rod 3, and the curable adhesive 4 is cured; to obtain the multi-contact nerve electrode 100. The curable glue 4 may be a UV glue or a heat curable glue.
When dispensing, the rod-shaped body 3 is vertically placed, one end with the electrode head 5 is located below, the curable adhesive 4 can be injected into the gap 32 through the dispenser, for example, a driving device can be used for carrying the dispenser to move circularly, so that the curable adhesive 4 is sequentially injected into the gap 32 of the adjacent layers, and the curable adhesive 4 gradually fills the gap 32 under the action of gravity so as to shape the nerve electrode through the curable adhesive 4.
It will be understood, of course, that in other embodiments, the rod-shaped body 3 is a hollow cylinder, and the curable adhesive 4 is injected into the hollow cylinder, that is, the outermost inner surface may be provided with the curable adhesive 4 or double sided adhesive, and the outermost side is fixed by the curable adhesive 4 or double sided adhesive when curled to the outermost side.
S5: referring to fig. 8, the flexible circuit board 6 is electrically connected to the conductive pins 22, and the sleeve 7 is sleeved on the rod 3, and the sleeve 7 protects the position where the flexible circuit board 6 is connected to the conductive pins 22. By connecting the flexible circuit board 6 to the conductive pins 22, brain signals can be acquired in real time; a sleeve 7 is placed over the wand 3 to provide a hand-held position when the electrode is implanted.
In this embodiment, after the rod-like body 3 is obtained, the electrode head 5 is sleeved, dispensed and cured, and the sleeve 7 and the connection flexible circuit board 6 are sleeved. It will be understood, of course, that the sleeving of the electrode head 5 may also be performed after dispensing, that is, so long as the above-described multi-contact nerve electrode 100 is finally obtained.
In this embodiment, the diameter of the multi-contact nerve electrode 100 is interposed between 0.6 and 2 mm. By adopting the scheme, the nerve electrode is little damaged when implanted into the brain, the rejection reaction of brain tissue to the electrode is reduced, and the nerve electrode needs to have higher space-time resolution for nerve signal measurement.
In summary, the signal acquisition layer 13 is formed by the existing very mature patterning technology, the flexible circuit board 1 is curled into a rod shape by a curling mode, and finally the curled flexible circuit board 1 is shaped and fixed by a glue injection mode, so that the yield of conductive patterns can be ensured, and the multi-contact nerve electrode 100 can be prepared in batches; the mask is also used when the flexible circuit board 1 is formed, but the mask can be repeatedly used, so that the preparation cost of the nerve electrode can be reduced.
A multi-contact nerve electrode 100 is also provided in one embodiment of the present application.
Referring to fig. 6, a multi-contact neural electrode 100 includes: a bar-shaped body 3, wherein the bar-shaped body 3 is formed by curling the flexible circuit board 1 along a preset direction. The rod-shaped body 3 includes opposite first and second ends, and an outer circumferential surface 31 of the first end is formed with electrode contacts 21 arranged in an array; the outer circumferential surface 31 of the second end is formed with a conductive pin 22, and the conductive pin 22 is electrically connected with the electrode contact 21 through a conductive line 23.
In this embodiment, a gap 32 is provided between adjacent layers of the curled flexible circuit board 1, and the gap 32 is filled with a curable adhesive 4, and the curable adhesive 4 is used for fixing the multi-contact neural electrode 100 in a rod shape.
In this embodiment, the second end of the rod 3 is sleeved with an electrode head 5. In the present embodiment, the multi-contact nerve electrode 100 has a flat or cylindrical shape.
Example 2
Referring to fig. 9, fig. 9 is a top view of a flexible circuit board 1 according to a second embodiment of the present application. Fig. 9 is substantially the same as fig. 3, and is different in that in this embodiment, the flexible circuit board 1 includes a plurality of repeating units, the flexible circuit board 1 is curled and fixed along a preset direction, and finally cut, so that a plurality of multi-contact nerve electrodes 100 can be obtained, and batch production of the multi-contact nerve electrodes 100 is realized.
Example 3
Referring to fig. 10, fig. 10 is a schematic diagram illustrating a flexible circuit board 1 according to a third embodiment of the present application. Fig. 10 is substantially the same as fig. 4, except that in this embodiment, in order to avoid the loosening of the process of curling the side where the curling is started into a cylindrical shape, a layer of fixing colloid 8 is formed on the side of the inner surface of the insulating substrate 11, or the starting end is fixed first.
It will be appreciated that the inner side of the outermost one of the loop layers curled to form the rod 3 may also be secured directly to its adjacent layer by means of a double sided adhesive.
Example 4
Referring to fig. 11, fig. 11 is a schematic structural diagram of a flexible circuit board 1 according to a fourth embodiment of the present application. Fig. 11 is substantially the same as fig. 3, except that in this embodiment, the flexible circuit board 1 is a multi-layer board, conductive vias (not shown) are further formed in the flexible circuit board 1, the conductive wires 23 are disposed in an inner layer of the flexible circuit board 1, and the electrode contacts 21 and the conductive pins 22 are electrically connected through the conductive vias and the conductive wires 23. By this arrangement, the space on the outer surface of the flexible wiring board 1 can be fully utilized, and as many electrode contacts 21 as possible can be provided.
The signal acquisition layer 13 further includes a plurality of temperature sensors 25, the temperature sensors 25 are disposed in one-to-one correspondence with the electrode contacts 21, and the temperature sensors 25 are electrically connected with the conductive pins 22. By doing so, the space between the electrode contacts 21 can be saved, and the temperature sensor 25 can be provided. When a voltage is applied between the two electrode contacts 21, a line of electric force is formed between the two electrode contacts 21, and a current flows between the electrode contacts 21, causing frictional heating between ions in cells in the tissue to ablate, which heating is of a certain range, and the temperature sensor 25 is used for sensing the maximum temperature.
In this embodiment, the temperature sensor 25 (typically a T-type thermocouple) monitors the temperature of the thermal condensation region, and utilizes the thermal condensation region temperature obtained in real time to timely and finely adjust the output power, thereby achieving the effect of precisely controlling the thermal condensation region temperature.
The foregoing are all preferred embodiments of the present application, and are not intended to limit the scope of the present application in any way, therefore: all equivalent changes in structure, shape and principle of this application should be covered in the protection scope of this application.
Claims (7)
1. A method for manufacturing a multi-contact nerve electrode, comprising the steps of:
providing a flexible circuit board (1), wherein the flexible circuit board (1) comprises an insulating substrate (11) and a signal acquisition layer (13) formed on the insulating substrate (11), and the signal acquisition layer (13) comprises a plurality of electrode contacts (21) arranged at intervals, conductive pins (22) formed at the end parts of the insulating substrate (11), and conductive circuits (23) communicated between the conductive pins (22) and the electrode contacts (21); and
sequentially curling the flexible circuit board (1) into a rod-shaped body (3) along a preset direction, wherein gaps (32) are arranged between adjacent layers of the rod-shaped body (3), curable glue (4) is injected into the gaps (32) from one end of the rod-shaped body (3), the curable glue (4) is cured to keep the shape of the rod-shaped body (3), the electrode contacts (21) and the conductive pins (22) are positioned on the outer circumferential surface (31) of the rod-shaped body (3) to obtain the multi-contact nerve electrode (100),
the flexible circuit board (1) is a multi-layer circuit board; the flexible circuit board (1) is also provided with a conductive via hole, the conductive circuit (23) is arranged on the inner layer of the flexible circuit board (1), and the electrode contact (21) and the conductive pin (22) are electrically conducted through the conductive via hole and the conductive circuit (23); and/or
The signal acquisition layer (13) further comprises a plurality of temperature sensors (25), and the temperature sensors (25) are arranged in one-to-one correspondence with the electrode contacts (21); and/or
The impedance of the conductive line is less than 50Ω.
2. The method for manufacturing the multi-contact nerve electrode according to claim 1, wherein the method comprises the following steps: the method further comprises the step of sleeving an electrode seal head (5) at one end of the rod-shaped body (3) opposite to the conductive pin (22) before injecting the curable adhesive (4) into the rod-shaped body (3) or after injecting the curable adhesive (4) into the rod-shaped body (3).
3. The method for manufacturing the multi-contact nerve electrode according to claim 1, wherein the method comprises the following steps: the electrode contacts (21) are arranged on the insulating substrate (11) in an array manner, and each electrode contact (21) is connected with one conductive pin (22) through one conductive circuit (23); and/or the electrode contact (21) and the conductive circuit (23) are also provided with a metal protection layer (24).
4. A method of manufacturing a multi-contact nerve electrode according to any one of claims 1 to 3, wherein: the diameter of the multi-contact nerve electrode (100) is 0.6-2 mm; and/or
The rod-shaped body (3) is flat or cylindrical.
5. A manufacturing method of a nerve electrode monitoring structure is characterized by comprising the following steps: providing a multi-contact neural electrode (100) formed by the multi-contact neural electrode manufacturing method according to any one of claims 1 to 4; and sleeving a sleeve (7) on the multi-contact nerve electrode (100) and electrically connecting a flexible circuit board (6) on the conductive pin (22), so that the sleeve (7) protects the connection position of the flexible circuit board (6) and the conductive pin (22) to obtain the nerve electrode monitoring structure (110).
6. A multi-contact neural electrode, comprising: a rod-shaped body (3), wherein the rod-shaped body (3) is formed by sequentially curling a flexible circuit board (1) along a preset direction, the rod-shaped body (3) comprises a first end and a second end which are opposite, and an outer circumferential surface (31) of the first end is provided with electrode contacts (21) which are arrayed; an outer circumferential surface (31) of the second end is formed with a conductive pin (22), and the conductive pin (22) is electrically connected with the electrode contact (21) through a conductive line (23); a gap (32) is arranged between adjacent layers of the curled flexible circuit board (1), curable glue (4) is filled in the gap (32) to keep the shape of the rod-shaped body (3), the flexible circuit board (1) is a multi-layer circuit board, and the flexible circuit board (1) comprises an insulating base material (11) and a signal acquisition layer (13) formed on the insulating base material (11); the flexible circuit board (1) is also provided with a conductive via hole, the conductive circuit (23) is arranged on the inner layer of the flexible circuit board (1), and the electrode contact (21) and the conductive pin (22) are electrically conducted through the conductive via hole and the conductive circuit (23); and/or
The signal acquisition layer (13) further comprises a plurality of temperature sensors (25), and the temperature sensors (25) are arranged in one-to-one correspondence with the electrode contacts (21); and/or
The impedance of the conductive line is less than 50Ω.
7. A multi-contact nerve electrode according to claim 6, wherein: the second end of the rod-shaped body (3) is sleeved with an electrode seal head (5); and/or
The multi-contact nerve electrode is flat or cylindrical.
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