CN117378759A - Liquid total nutrient formula composition suitable for acute pancreatitis and preparation method thereof - Google Patents

Liquid total nutrient formula composition suitable for acute pancreatitis and preparation method thereof Download PDF

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Publication number
CN117378759A
CN117378759A CN202311431740.6A CN202311431740A CN117378759A CN 117378759 A CN117378759 A CN 117378759A CN 202311431740 A CN202311431740 A CN 202311431740A CN 117378759 A CN117378759 A CN 117378759A
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percent
acute pancreatitis
stirring
protein
total nutrient
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李然然
刘志友
何伟
付劼
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Beijing Xihong Runmei Pharmaceutical Technology Co ltd
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Beijing Xihong Runmei Pharmaceutical Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
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Abstract

The invention discloses a liquid total nutrient formula composition suitable for acute pancreatitis and a preparation method thereof, and particularly relates to the technical field of food design. The composition comprises: 15 to 20 percent of carbohydrate, 3 to 5 percent of hydrolyzed protein, 3 to 2.5 percent of plant polypeptide, 1.2 to 2.5 percent of fat, 0.2 to 0.8 percent of fructo-oligosaccharide, 2 to 4 percent of inulin, 0.3 to 0.8 percent of gardenia extract, 0.03 to 0.08 percent of emodin, 0.3 to 1.5 percent of compound stabilizer, 0.1 to 0.8 percent of compound vitamin, 1 to 6 percent of compound mineral, 0.8 to 1.2 percent of taurine, 0.1 to 0.35 percent of acidity regulator, 0.005 to 0.025 percent of edible essence and the balance of water. The invention is a specific total nutrient formula food for the acute pancreatitis, has simple operation, can be orally taken and tube fed, can provide nutrition support for the intestines of patients with the acute pancreatitis, promote the recovery of the functions of the intestines, and reduce the occurrence of infection and complications; the product of the invention can also be used as a single nutrient source.

Description

Liquid total nutrient formula composition suitable for acute pancreatitis and preparation method thereof
Technical Field
The invention relates to the technical field of foods, in particular to a liquid total nutrient formula composition suitable for acute pancreatitis and a preparation method thereof.
Background
The formula food for special medical use (hereinafter referred to as "special medical food") is a type of formula food specially processed and prepared for meeting special requirements of people with limited eating, digestive absorption disorder, metabolic disorder or specific disease state on nutrients or diet. The invention is guided by GB 29922 general rules of food safety national standard special medical use formula food, and is mainly applicable to patients with acute pancreatitis with nutritional risk or malnutrition over 10 years old.
Acute pancreatitis is a common acute abdomen in clinic, the onset of which has a certain relationship with the secretion mechanism of pancreas and bile, and various causes cause the activation of pancreatic enzymes in the pancreas to produce inflammatory reactions of tissue digestion, edema, hemorrhage and even necrosis. Thereby causing the organism to have low nutrition and rapidly decline in immune function. Patients with acute pancreatitis should stop eating orally, and after 2-3 days after onset, intestinal function is recovered, and the patients should be transferred to enteral nutrition as soon as possible. Patients with acute pancreatitis have a high energy consumption, a negative nitrogen balance occurs, and at the same time, the secretion of pancreatic enzymes due to inflammation is reduced, and lipolysis is a burden. The product is suitable for liquid total nutrient food for acute pancreatitis above 10 years old, and the protein mainly comprises hydrolyzed protein, including hydrolyzed whey protein of animal origin and soybean peptide of plant origin; the fat contains 50-55% of Medium Chain Triglyceride (MCT) and fish oil components, and simultaneously contains inulin, fructo-oligosaccharide and other prebiotic components, and gardenia and rhein which are homologous in medicine and food, and has effects in regulating immunity, protecting liver, promoting bile flow, reducing blood sugar, regulating lipid, resisting inflammation, resisting oxidative stress and other aspects.
Currently, there are few total nutrient foods for acute pancreatitis in the market, and powder products are mainly used. However, the powder is inconvenient to eat because of being brewed.
Disclosure of Invention
Therefore, the invention provides a liquid total nutrient formula composition suitable for acute pancreatitis and a preparation method thereof, which are used for solving the problems of less total nutrient food for acute pancreatitis, inconvenient eating and the like.
In order to achieve the above object, the present invention provides the following technical solutions:
a liquid total nutrient formulation composition suitable for acute pancreatitis, the composition comprising: 15 to 20 percent of carbohydrate, 3 to 5 percent of hydrolyzed protein, 3 to 2.5 percent of plant polypeptide, 1.2 to 2.5 percent of fat, 0.2 to 0.8 percent of fructo-oligosaccharide, 2 to 4 percent of inulin, 0.3 to 0.8 percent of gardenia extract, 0.03 to 0.08 percent of emodin, 0.3 to 1.5 percent of compound stabilizer, 0.1 to 0.8 percent of compound vitamin, 1 to 6 percent of compound mineral, 0.8 to 1.2 percent of taurine, 0.1 to 0.35 percent of acidity regulator, 0.005 to 0.025 percent of edible essence and the balance of water.
Further, the carbohydrate is maltodextrin.
Further, the hydrolyzed protein and the plant polypeptide are hydrolyzed whey protein and soybean peptide respectively.
Further, the ratio of the hydrolyzed whey protein to the soybean peptide is 1:1, a step of; the hydrolysis degree of the hydrolyzed whey protein is more than 18%; the hydrolysis degree of the soybean peptide is 10-20%.
Further, the fat is derived from MCT, fish oil and vegetable oil, wherein the proportion of MCT in the fat is 50-55%, and the proportion of fish oil in the fat is not less than 8%.
Further, the vegetable oil source is preferably one or more of corn oil, sunflower seed oil, soybean oil, rapeseed oil and coconut oil.
Further, the ratio of the gardenia extract to the emodin is 10:1.
further, the compound stabilizer comprises a thickening agent and an emulsifying agent, wherein the thickening agent comprises pectin, xanthan gum and carrageenan, and the emulsifying agent comprises sodium caseinate, mono-diglyceride fatty acid ester and citric acid fatty acid glyceride.
Further, the compound vitamin comprises one or more of vitamin A, vitamin D, vitamin E, vitamin K1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, pantothenic acid, vitamin C and biotin.
Further, the composite mineral comprises one or more of sodium, potassium, copper, magnesium, iron, zinc, manganese, calcium, phosphorus, iodine, chlorine and selenium.
Further, the acidity regulator is phosphoric acid; preferably, the pH of the product of the invention is 3.3-3.9.
The raw materials have the following functions:
inulin and fructooligosaccharides:
inulin and fructo-oligosaccharide are used as functional food raw materials, and have double effects of dietary fiber and prebiotics.
Inulin can be hydrolyzed into fructose or fructo-oligosaccharides, and the influence of inulin on human health is very similar to that of fructo-oligosaccharides; (1) Can proliferate bifidobacteria in intestinal tracts and prevent intestinal infection; (2) The inulin can be used as dietary fiber to absorb fat in intestines to form a fat-fiber compound which is discharged along with feces, thereby being beneficial to reducing the blood fat level; (3) The absorption of minerals is promoted, dietary fibers in daily diet can reduce the absorption of certain minerals by the intestinal tract, any inulin-mineral complex can be degraded in the fermentation process of intestinal flora, and mineral elements are released, so that the absorption of the minerals by the intestinal tract is facilitated; (4) The constipation is prevented and treated, inulin is supplemented daily in the diet according to recommended dosage, so that the defecation frequency of constipation patients can be obviously increased, and the defecation becomes soft and coherent.
Fructo-oligosaccharide is a water-soluble dietary fiber, and can improve intestinal flora balance, improve lipid metabolism and promote mineral element absorption. The fructooligosaccharides have been found to have excellent physiological properties: (1) The bifidobacterium can be selectively utilized in the large intestine, and the number of the bifidobacterium in the body can be increased by 100-1000 times after the fructo-oligosaccharide is taken in; (2) Is difficult to hydrolyze by digestive tract salivary enzymes and small intestine digestive enzymes of human body, and is a low calorie sugar; (3) Can be considered as water-soluble dietary fiber, can reduce blood lipid, improve lipid metabolism, and reduce cholesterol, triglyceride and free fatty acid after administration; (4) Inhibit growth of Salmonella and putrefying bacteria in intestine, and promote gastrointestinal function.
Taurine: taurine is an indispensable amino acid of human beings, and can enhance the curative effect of anti-inflammatory drugs and reduce adverse reactions thereof by enhancing the immunity of the organism and affecting the cellular uptake and excretion of anti-tumor drugs; taurine inhibits tumor growth by increasing the antioxidant capacity of the body.
Gardenia jasminoides ellis extract: has effects of purging pathogenic fire, relieving restlessness, clearing heat, promoting urination, cooling blood, and removing toxic substances. Can be used for treating febrile vexation, jaundice, dark urine, stranguria, pain due to blood heat, epistaxis, swelling and pain of eye, and pyocutaneous disease and sprain.
Hydrolyzed protein: is prepared from cheese pigment or blood fiber through acidolysis or enzymolysis to provide necessary amino acids for anabolism of organism to maintain the balance of nitrogen in vivo. Can be used for protein deficiency due to malnutrition, protein digestion and absorption, or excessive consumption, severe gastroenteritis, scald, and protein supplementation after surgical operation.
Plant polypeptide: polypeptides have a very important, non-alternative regulatory role in the human body, which is involved in almost all physiological activities of the human body. Such as: nerves, digestion, absorption, metabolism, circulation, growth, reproduction, endocrine, and the like. There are many studies on polypeptides currently being developed for use in medicine and health foods. Insulin, which is familiar to us, is a polypeptide, and oxytocin and vasopressin are both polypeptide hormones. In high-rhythmic, highly stressed society, people with abnormal sleep are expanding, and hypnotic peptides would be the best choice as they have no side effects. Other effective drugs, such as those for treating diabetes, gastric ulcers, pancreatitis, dwarfism, and gallbladder contraction, are all polypeptides. For the immune system of human body, the polypeptide is more important and direct, such as mannatide, thymus peptide, albumin polypeptide, etc., and can activate macrophage, T cell, etc. fast, so as to raise the immune level of human body cell and prevent infection caused by coronavirus.
Emodin: the "Chinese herbal medicine menstruation" records that the raw rhubarb can "lower blood stasis, block cold and heat of blood, break diseases and slightly waste accumulation, leave food for food retention, purge intestines and stomach, promote old and promote new growth, promote diuresis, regulate middle warmer and promote food retention, and calm five internal organs", so that the treatment effect of the Chinese herbal medicine on acute pancreatitis is widely studied and widely accepted by domestic scholars. In recent years, a plurality of clinical and experimental studies' confirm the exact curative effects of raw rhubarb on acute pancreatitis, including inhibition of pancreatic inflammatory reaction, improvement of pancreatic microcirculation and exocrine functions, etc. The emodin is a main active ingredient of the raw rhubarb, and the anti-inflammatory effect of the emodin is proved by a plurality of domestic and foreign researches at present, so that the emodin not only can reduce the level of inflammatory factors such as serum L-IL6, TNF and the like, but also can reduce the MPO activity of lung tissues.
Vitamins and minerals: vitamins and minerals are essential nutrients for human bodies, and the vitamins added in the invention are vitamins and minerals which are essential nutrients for human bodies;
further, the dosage form of the present invention is a liquid.
According to another aspect of the present invention, there is provided a method of preparing a liquid total nutrient formulation composition suitable for acute pancreatitis, comprising the steps of:
s1, selecting materials according to a preset proportion, removing the outer package of the materials, sterilizing, and conveying to a weighing room;
s2, preparing a water phase mixed solution: uniformly stirring and mixing water, the gardenia extract, 1/2 maltodextrin and the compound mineral matters to obtain a water phase mixed solution;
s3, preparing casein-emodin microcapsules: adding casein into a proper amount of water, stirring and dissolving to obtain casein micelle solution; adding emodin into 10ml of absolute ethanol, stirring for dissolving, and then mixing with casein micelle solution, stirring for 30min to obtain casein-emodin microcapsule;
s4, mixing oil phases: mixing MCT, fish oil, vegetable oil, casein-emodin microcapsule, and stirring to obtain oil phase mixture;
s5, stabilizer premix: stirring and mixing water, a compound stabilizer, inulin and fructo-oligosaccharide, heating and stirring at 60-80 ℃ for 30min for dissolution to obtain a stabilizer premix;
s6, protein-polysaccharide mixed solution: mixing water, hydrolyzed whey protein, soybean peptide and 1/2 maltodextrin under stirring, and thermally dissolving at 55-75 ℃ to obtain a protein-polysaccharide mixed solution;
s7, hydrating the protein-polysaccharide mixed solution at 55-75 ℃ for 10-60 min;
s8, sequentially adding the stabilizer premix, the water phase mixed solution and the oil phase mixed solution into the protein-polysaccharide mixed solution, stirring at 600-1000 rpm for 10min, uniformly mixing, and then cooling to 40 ℃;
s9, adding the compound vitamin and taurine into the S8 feed liquid, and stirring for 10min to disperse and dissolve;
s10, adding an acidity regulator and edible essence into the feed liquid of the step S9, and stirring for 10min to disperse and dissolve;
s11, transferring the S10 feed liquid to a shearing tank, and shearing for 20-60 min at 2000-4000 rpm;
s12, homogenizing the S11 feed liquid for 3 times under the homogenizing pressure of 200-800 bar;
s13, sub-packaging the S12 feed liquid into packaging containers, and sealing;
s14, finally, terminal sterilization is carried out, and the sterilization temperature is 100-115 ℃ to obtain the liquid acute pancreatitis total nutrient formula composition.
The invention has the following advantages:
the composition provided by the invention has the advantages that the protein sources are mainly hydrolyzed whey protein and soybean peptide, and compared with an integral protein formula, the composition provided by the invention has smaller molecular weight and better absorbability, and can provide better and faster protein supplementation for negative nitrogen balance of patients suffering from acute pancreatitis.
The fat sources in the composition of the invention are MCT and vegetable oil, wherein the MCT accounts for 50-55%, and the fish oil accounts for not less than 8% of the total fat. The MCT has the characteristics of quick hydrolysis and easy absorption, and is especially suitable for patients with acute pancreatitis with weak gastrointestinal functions and easy occurrence of fat leakage; fish oil can enhance immunity and reduce inflammatory reaction.
Inulin and fructo-oligosaccharide are added into the composition provided by the invention, so that the composition has the prebiotic property, has beneficial effects on promoting the proliferation of bifidobacteria, maintaining intestinal health and thickening immunity, and improves the prognosis of patients.
The composition disclosed by the invention is added with the gardenia extract and the emodin which are homologous to each other in medicine and food, wherein the gardenia has the effects of resisting inflammation, protecting liver and promoting bile flow, and the emodin has the effects of resisting oxidation, inhibiting bacteria and resisting inflammation, has the effect of protecting intestinal mucosa barrier injury of acute pancreatitis, and inhibits inflammatory injury.
The composition of the invention is added with the taurine which is a nutrition component, can promote the secretion of pituitary hormone and activate the pancreas function, thereby improving the state of the endocrine system of the organism and beneficial to the regulation of the metabolism of the organism; and has the effects of enhancing immunity of organism and relieving fatigue.
The composition solves the problem of poor solubility of emodin in aqueous solution by preparing casein-emodin microcapsules.
The composition is a liquid preparation, can be directly drunk, can be directly subjected to tube feeding, and is convenient to operate and good in stability; lowering the patient use threshold. The preparation method comprises the main procedures of weighing, preparing, homogenizing, canning, sterilizing and the like; is suitable for patients with acute pancreatitis with nutritional risk or malnutrition above 10 years old.
The invention is a specific total nutrient formula food for the acute pancreatitis, has simple operation, can be orally taken and tube fed, can provide nutrition support for the intestines of patients with the acute pancreatitis, promote the recovery of the functions of the intestines, and reduce the occurrence of infection and complications; the product of the invention can also be used as a single nutrient source.
Detailed Description
Other advantages and advantages of the present invention will become apparent to those skilled in the art from the following detailed description, which, by way of illustration, is to be read in connection with certain specific embodiments, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The protein material ratios were analyzed and screened and the results are shown in tables 1 and 2.
TABLE 1
TABLE 2
In tables 1 and 2:
RAA amino acid ratio: amino acid content/pattern amino acid content in food;
RCAA amino acid ratio coefficient: amino acid ratio/average of amino acid ratios;
the SRCAA amino acid ratio coefficients are: "srcca=100-cv×100
CV is the coefficient of variation of RCAA, CV = standard deviation/mean ";
both hydrolyzed whey protein and soy peptide are high quality proteins, and the essential amino acids of the protein material are better than recommended compared to WHO/FAO (2013) recommended adult amino acid intake. Meanwhile, hydrolyzed whey protein and soy peptide were prepared according to 1:1 ratio, the ratio of the essential amino acids of the product is greater than 1, which indicates that the essential amino acids in the product are completely similar to the amino acid composition of human body, are easier to be utilized by human body and have higher nutritive value.
The RCAA number is equal to 1, indicating that the amino acid composition in the hydrolysate is consistent with the amino acid pattern, and the more dispersed the RCAA of the food protein, the greater the negative contribution of these amino acids on the amino acid balance. Hydrolyzed whey protein and soy peptide were prepared according to 1:1 ratio, the RCAA data are all around 1, and the fluctuation is smaller compared with the single protein raw material.
The smaller the SRCAA, the poorer the nutritional value of the protein. The SRCAA values of the patent are larger than the RCAA values of the independent hydrolyzed whey protein and soybean peptide, so that the amino acid composition in the hydrolysate is closer to an amino acid mode, and the effect of absorbing essential amino acids by human bodies is better.
The ratio of hydrolysed whey protein to soy peptide was thus finally selected to be 1:1.
example 1
The liquid total nutrient formula suitable for acute pancreatitis is prepared by adopting the following raw materials:
15% of carbohydrate, 3% of protein, 1.3% of fat, 0.5% of fructo-oligosaccharide, 2% of inulin, 0.5% of gardenia extract, 0.05% of emodin, 0.6% of compound stabilizer, 0.4% of compound vitamin, 2% of compound mineral, 0.8% of taurine, 0.25% of acidity regulator, 0.005% of edible essence and the balance of water, wherein the total amount is 100ml per part.
The carbohydrate source of the invention is maltodextrin.
The hydrolyzed protein sources of the invention are hydrolyzed whey protein and soybean peptide, and the proportion is 1:1.
the hydrolysis degree of the hydrolyzed whey protein is above 18%, and the hydrolysis degree of the soybean peptide is 10-20%.
The compound stabilizer comprises a thickening agent and an emulsifying agent, wherein the thickening agent comprises pectin, xanthan gum and carrageenan, and the emulsifying agent comprises mono-diglyceride fatty acid ester and citric acid fatty acid glyceride.
The compound vitamins comprise vitamin A, vitamin D, vitamin E, vitamin K1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, pantothenic acid, vitamin C, and biotin.
The composite mineral comprises sodium, potassium, copper, magnesium, iron, zinc, manganese, calcium, phosphorus, iodine, chlorine and selenium.
The acidity regulator is disodium hydrogen phosphate.
The pH of the invention was 3.9.
Example 2
The liquid total nutrient formula suitable for acute pancreatitis is prepared by adopting the following raw materials:
18% of carbohydrate, 3.5% of protein, 2% of fat, 0.4% of fructo-oligosaccharide, 3% of inulin, 0.6% of gardenia extract, 0.06% of emodin, 1.0% of compound stabilizer, 0.5% of compound vitamin, 5% of compound mineral, 1.0% of taurine, 0.4% of acidity regulator, 0.005% of edible essence and 65% of water, wherein the total amount is 100ml per part.
The carbohydrate source of the invention is maltodextrin.
The hydrolyzed protein sources of the invention are hydrolyzed whey protein and soybean peptide, and the proportion is 1:1.
the hydrolysis degree of the hydrolyzed whey protein is above 18%, and the hydrolysis degree of the soybean peptide is 10-20%.
The compound stabilizer comprises a thickening agent and an emulsifying agent, wherein the thickening agent comprises pectin, xanthan gum and carrageenan, and the emulsifying agent comprises mono-diglyceride fatty acid ester and citric acid fatty acid glyceride.
The compound vitamins comprise vitamin A, vitamin D, vitamin E, vitamin K1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, pantothenic acid, vitamin C, and biotin.
The composite mineral comprises sodium, potassium, copper, magnesium, iron, zinc, manganese, calcium, phosphorus, iodine, chlorine and selenium.
The acidity regulator is disodium hydrogen phosphate.
The pH of the invention was 3.5.
Example 3
The liquid total nutrient formula suitable for acute pancreatitis is prepared by adopting the following raw materials:
16% of carbohydrate, 4% of protein, 2.3% of fat, 0.6% of fructo-oligosaccharide, 2.5% of inulin, 0.8% of gardenia extract, 0.08% of emodin, 1.3% of compound stabilizer, 0.3% of compound vitamin, 4% of compound mineral, 0.9% of taurine, 0.5% of acidity regulator, 0.01% of edible essence and 67% of water, wherein the total amount is 100ml per part.
The carbohydrate source of the invention is maltodextrin.
The hydrolyzed protein sources of the invention are hydrolyzed whey protein and soybean peptide, and the proportion is 1:1.
the hydrolysis degree of the hydrolyzed whey protein is above 18%, and the hydrolysis degree of the soybean peptide is 10-20%.
The compound stabilizer comprises a thickening agent and an emulsifying agent, wherein the thickening agent comprises pectin, xanthan gum and carrageenan, and the emulsifying agent comprises mono-diglyceride fatty acid ester and citric acid fatty acid glyceride.
The compound vitamins comprise vitamin A, vitamin D, vitamin E, vitamin K1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, pantothenic acid, vitamin C, and biotin.
The composite mineral comprises sodium, potassium, copper, magnesium, iron, zinc, manganese, calcium, phosphorus, iodine, chlorine and selenium.
The acidity regulator is disodium hydrogen phosphate.
The pH of the invention was 3.4.
Example 4
The liquid total nutrient formula suitable for acute pancreatitis is prepared from the following raw materials:
20% of carbohydrate, 3.2% of protein, 2% of fat, 0.3% of fructo-oligosaccharide, 3.6% of inulin, 0.3% of gardenia extract, 0.03% of emodin, 1.2% of compound stabilizer, 0.4% of compound vitamin, 4.5% of compound mineral, 1.0% of taurine, 0.5% of acidity regulator, 0.01% of edible essence and 63% of water, wherein the total amount is 100ml per part.
The carbohydrate source of the invention is maltodextrin.
The hydrolyzed protein sources of the invention are hydrolyzed whey protein and soybean peptide, and the proportion is 1:1.
the hydrolysis degree of the hydrolyzed whey protein is above 18%, and the hydrolysis degree of the soybean peptide is 10-20%.
The compound stabilizer comprises a thickening agent and an emulsifying agent, wherein the thickening agent comprises pectin, xanthan gum and carrageenan, and the emulsifying agent comprises mono-diglyceride fatty acid ester and citric acid fatty acid glyceride.
The compound vitamins comprise vitamin A, vitamin D, vitamin E, vitamin K1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, pantothenic acid, vitamin C, and biotin.
The composite mineral comprises sodium, potassium, copper, magnesium, iron, zinc, manganese, calcium, phosphorus, iodine, chlorine and selenium.
The acidity regulator is disodium hydrogen phosphate.
The pH of the invention was 3.7.
Comparative example 1
This comparative example is exactly the same as example 2 except that the gardenia extract and emodin are not added.
Example 5
For examples 1-4, the preparation method of the liquid total nutrient formula suitable for acute pancreatitis is as follows:
s1, selecting materials according to a preset proportion, removing the outer package of the materials, sterilizing, and conveying to a weighing room.
S2, preparing a water phase mixed solution: mixing water, fructus Gardeniae extract, 1/2 maltodextrin and compound mineral substance under stirring to obtain water phase mixture.
S3, preparing casein-emodin microcapsules: adding casein into proper amount of water, stirring and dissolving to obtain casein micelle solution. Adding emodin into 10ml absolute ethanol, stirring for dissolving, and mixing with casein micelle solution, stirring for 30min to obtain casein-emodin microcapsule.
S4, mixing oil phases: mixing MCT, fish oil, vegetable oil, casein-emodin microcapsule, and stirring to obtain oil phase mixture.
S5, stabilizer premix: mixing water, compound stabilizer, inulin and fructo-oligosaccharide under stirring, heating at 60-80 ℃ under stirring for 30min for dissolving, and obtaining stabilizer premix.
S6, protein-polysaccharide mixed solution: mixing water, hydrolyzed whey protein, soybean peptide and 1/2 maltodextrin under stirring, and dissolving at 55-75deg.C to obtain protein-polysaccharide mixture.
S7, hydrating the protein-polysaccharide mixed solution at 55-75 ℃ for 10-60 min.
S8, sequentially adding the stabilizer premix, the water phase mixed solution and the oil phase mixed solution into the protein-polysaccharide mixed solution, stirring at 600-1000 rpm for 10min, uniformly mixing, and cooling to 40 ℃.
S9, adding the compound vitamin and taurine into the feed liquid, and stirring for 10min to disperse and dissolve.
S10, adding an acidity regulator and edible essence into the feed liquid, and stirring for 10min to disperse and dissolve.
S11, transferring the feed liquid to a shearing tank, and shearing for 20-60 min at 2000-4000 rpm.
S12, homogenizing the feed liquid for 3 times under the homogenizing pressure of 200-800 bar.
S13, sub-packaging the feed liquid into packaging containers, and sealing.
S14, finally, terminal sterilization is carried out, and the sterilization temperature is 100-115 ℃ to obtain the liquid acute pancreatitis total nutrient formula food.
Experimental example 1
The liquid total nutrient formulas for acute pancreatitis obtained in examples 1 to 4 were each examined for stability by the following method:
examples 1-4 liquid total nutrient formula food suitable for acute pancreatitis was stored at different storage temperatures of 4 ℃ and 30 ℃ for 30 days, respectively, and the sensory state, particle size, and centrifugal sedimentation rate of the product were measured at 0, 15, and 30 days, respectively.
Sensory state determination method: under the condition of room temperature, taking a certain amount of uniformly mixed measured samples, placing the samples into a beaker, observing the color and the state under natural light, and checking whether foreign matters exist or not.
The particle size measurement method comprises the following steps: the particle size is measured by a laser particle sizer under the room temperature condition, and the addition amount of each time is in the range of 6-10 ml.
The centrifugal sedimentation rate measuring method comprises the following steps: shaking the sample solution evenly, measuring a proper amount of sample solution, and placing the sample solution into a weighed centrifuge tube(mass is denoted as m 0 ) In the method, the total mass of the sample and the centrifuge tube is weighed and recorded as m 1 The method comprises the steps of carrying out a first treatment on the surface of the Setting the rotation speed of the centrifugal machine at 4000r/min, centrifuging for 20min, discarding the upper liquid layer by using a suction pipe, weighing the centrifuged sample and the quality of the centrifugal tube, and recording as m 2 The centrifugal sedimentation rate M, i.e., M= (M) 2 -m 0 )/(m 1 -m 0 )×100％。
The results are shown in tables 3 to 6.
Table 3 example 1 stability investigation
Table 4 example 2 stability investigation
Table 5 example 3 stability investigation
Table 6 example 4 stability investigation
As can be seen from tables 4 to 6, examples 1 to 4 were stored at 4℃and 30℃for 30 days, and the sensory state of the products was not significantly changed, indicating that the products did not significantly affect the state of the products at both low-temperature storage and accelerated aging.
From Stokes' law, the stability of a system is proportional to the square of the radius of particles, and the larger the particles, the easier the sedimentation and separation are. Examples 1 to 4 had a tendency to increase in particle size both during storage at 4℃and 30℃and the particle size increase in the 30℃accelerated test was more pronounced, which is a tendency of the product to agglomerate with each other between particles during storage, but since the product was subjected to a homogenization treatment, the product particle size was compressed to a stable particle size range, and even if the particles agglomerate due to the action of gravity, the product stability was not affected. Thus, the particle size change upon both cold storage and accelerated storage is within an acceptable range.
The centrifugal sedimentation rate can comprehensively evaluate the influence of the particle size on the stability of the emulsion system due to the action of centrifugal force, and the lower the value is, the better the emulsion stability is. The centrifugal sedimentation rates of the examples 1-4 are all within 1.5%, the state is good, the emulsion particles are small, and the product stability is good.
Experimental example 2
200 pancreatitis patients are selected, and divided into 5 groups of 40 patients, wherein the compositions of examples 1-4 and comparative example 1 are taken by each group of men and women, and the compositions are matched with medicines for normally treating pancreatitis, and the recovery time is shown in Table 7.
TABLE 7
Therefore, the composition can assist in recovery of pancreatitis patients, and the gardenia extract and the emodin have a certain effect on assisting in diminishing inflammation of pancreatitis patients, so that recovery time of pancreatitis can be obviously shortened by adding the gardenia extract and the emodin.
While the invention has been described in detail in the foregoing general description and specific examples, it will be apparent to those skilled in the art that modifications and improvements can be made thereto. Accordingly, such modifications or improvements may be made without departing from the spirit of the invention and are intended to be within the scope of the invention as claimed.

Claims (8)

1. A liquid total nutrient formulation composition suitable for acute pancreatitis, the composition comprising: 15 to 20 percent of carbohydrate, 3 to 5 percent of hydrolyzed protein, 3 to 2.5 percent of plant polypeptide, 1.2 to 2.5 percent of fat, 0.2 to 0.8 percent of fructo-oligosaccharide, 2 to 4 percent of inulin, 0.3 to 0.8 percent of gardenia extract, 0.03 to 0.08 percent of emodin, 0.3 to 1.5 percent of compound stabilizer, 0.1 to 0.8 percent of compound vitamin, 1 to 6 percent of compound mineral, 0.8 to 1.2 percent of taurine, 0.1 to 0.35 percent of acidity regulator, 0.005 to 0.025 percent of edible essence and the balance of water.
2. The liquid total nutrient formulation composition suitable for use in acute pancreatitis according to claim 1, wherein the carbohydrate is maltodextrin.
3. The liquid total nutrient formulation composition for use in acute pancreatitis according to claim 1, wherein the hydrolyzed protein and plant polypeptide are hydrolyzed whey protein and soy peptide, respectively.
4. The liquid total nutritional formula composition suitable for acute pancreatitis according to claim 1, characterized in that the ratio of hydrolyzed whey protein and soy peptide is 1:1, a step of; the hydrolysis degree of the hydrolyzed whey protein is more than 18%; the hydrolysis degree of the soybean peptide is 10-20%.
5. The liquid total nutrient formulation composition for acute pancreatitis as claimed in claim 1, wherein the fat is derived from MCT, fish oil, vegetable oil, wherein MCT accounts for 50-55% of the fat, and fish oil accounts for not less than 8% of the fat.
6. The liquid total nutrient formulation composition for use in acute pancreatitis according to claim 1, wherein the ratio of gardenia extract to emodin is 10:1.
7. the liquid total nutrient formulation composition suitable for use in acute pancreatitis according to claim 1, wherein the acidity regulator is phosphoric acid.
8. A method of preparing a liquid total nutrient formulation composition suitable for acute pancreatitis, comprising the steps of:
s1, selecting materials according to a preset proportion, removing the outer package of the materials, sterilizing, and conveying to a weighing room;
s2, preparing a water phase mixed solution: uniformly stirring and mixing water, the gardenia extract, 1/2 maltodextrin and the compound mineral matters to obtain a water phase mixed solution;
s3, preparing casein-emodin microcapsules: adding casein into a proper amount of water, stirring and dissolving to obtain casein micelle solution; adding emodin into 10ml of absolute ethanol, stirring for dissolving, and then mixing with casein micelle solution, stirring for 30min to obtain casein-emodin microcapsule;
s4, mixing oil phases: mixing MCT, fish oil, vegetable oil, casein-emodin microcapsule, and stirring to obtain oil phase mixture;
s5, stabilizer premix: stirring and mixing water, a compound stabilizer, inulin and fructo-oligosaccharide, heating and stirring at 60-80 ℃ for 30min for dissolution to obtain a stabilizer premix;
s6, protein-polysaccharide mixed solution: mixing water, hydrolyzed whey protein, soybean peptide and 1/2 maltodextrin under stirring, and thermally dissolving at 55-75 ℃ to obtain a protein-polysaccharide mixed solution;
s7, hydrating the protein-polysaccharide mixed solution at 55-75 ℃ for 10-60 min;
s8, sequentially adding the stabilizer premix, the water phase mixed solution and the oil phase mixed solution into the protein-polysaccharide mixed solution, stirring at 600-1000 rpm for 10min, uniformly mixing, and then cooling to 40 ℃;
s9, adding the compound vitamin and taurine into the S8 feed liquid, and stirring for 10min to disperse and dissolve;
s10, adding an acidity regulator and edible essence into the feed liquid of the step S9, and stirring for 10min to disperse and dissolve;
s11, transferring the S10 feed liquid to a shearing tank, and shearing for 20-60 min at 2000-4000 rpm;
s12, homogenizing the S11 feed liquid for 3 times under the homogenizing pressure of 200-800 bar;
s13, sub-packaging the S12 feed liquid into packaging containers, and sealing;
s14, finally, terminal sterilization is carried out, and the sterilization temperature is 100-115 ℃ to obtain the liquid acute pancreatitis total nutrient formula composition.
CN202311431740.6A 2023-10-31 2023-10-31 Liquid total nutrient formula composition suitable for acute pancreatitis and preparation method thereof Pending CN117378759A (en)

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