CN117269385A - Sample injection plate of liquid chromatograph or liquid chromatograph tandem mass spectrometer - Google Patents
Sample injection plate of liquid chromatograph or liquid chromatograph tandem mass spectrometer Download PDFInfo
- Publication number
- CN117269385A CN117269385A CN202311264887.0A CN202311264887A CN117269385A CN 117269385 A CN117269385 A CN 117269385A CN 202311264887 A CN202311264887 A CN 202311264887A CN 117269385 A CN117269385 A CN 117269385A
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- mass spectrometer
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- 239000007788 liquid Substances 0.000 title claims abstract description 92
- 238000002347 injection Methods 0.000 title description 3
- 239000007924 injection Substances 0.000 title description 3
- 238000007789 sealing Methods 0.000 claims abstract description 99
- 238000005070 sampling Methods 0.000 claims abstract description 86
- 230000000694 effects Effects 0.000 claims abstract description 9
- 238000004891 communication Methods 0.000 claims description 16
- 230000000712 assembly Effects 0.000 claims description 4
- 238000000429 assembly Methods 0.000 claims description 4
- 238000001514 detection method Methods 0.000 abstract description 16
- 239000002699 waste material Substances 0.000 abstract description 5
- 238000000034 method Methods 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 230000003068 static effect Effects 0.000 description 5
- 238000005096 rolling process Methods 0.000 description 4
- 230000001360 synchronised effect Effects 0.000 description 3
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003891 environmental analysis Methods 0.000 description 1
- 231100000775 forensic toxicology Toxicity 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000000447 pesticide residue Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000004454 trace mineral analysis Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
The utility model relates to a mass spectrometer sampling device's technical field especially relates to a liquid chromatograph or liquid chromatograph tandem mass spectrometer sample plate, and it includes the plate body, a plurality of sampling holes have been seted up on the plate body, be provided with sealing mechanism on the plate body, sealing mechanism includes the closing plate, the closing plate activity in on the plate body and right the sampling hole shelters from, a plurality of sampling holes have been seted up on the closing plate, the sampling hole can with sampling hole intercommunication and along with the activity of closing plate make the sampling hole expose. This application has the waste that reduces detection liquid, reduces the effect to operational environment's pollution.
Description
Technical Field
The application relates to the technical field of mass spectrometer sampling devices, in particular to a liquid chromatograph or a liquid chromatograph tandem mass spectrometer sampling plate.
Background
Currently, the tandem mass spectrometer is widely applied to the field of life science, from basic research to drug discovery and development, detection of pesticide residues in functional medicine, food safety and environmental analysis, and detection of trace analysis of forensic toxicology and clinical research, and the like. In the using process of the liquid chromatograph tandem mass spectrometer, a sample plate is usually used for containing liquid to be detected, the existing sample plate has a simpler structure, generally a plate is provided with a plurality of sample grooves, the liquid to be detected is dripped into the sample grooves, and then the sample plate is placed into the liquid chromatograph tandem mass spectrometer for detection; when the sample is detected, the sample tank can be rotated to the sampling end of the mass spectrometer for sampling by driving the sample plate to rotate.
In the process of implementing the application, the inventor finds that at least the following problems exist in the technology, and when a sample plate is moved into a liquid chromatograph tandem mass spectrometer, liquid to be detected is easy to spill out, so that the problem of waste of the liquid to be detected and pollution to the working environment is caused.
Disclosure of Invention
In order to reduce waste of detection liquid and reduce pollution to working environment, the application provides a liquid chromatograph or a liquid chromatograph tandem mass spectrometer sample feeding plate.
The application provides a liquid chromatograph or liquid chromatograph tandem mass spectrometer sampling plate adopts following technical scheme:
the utility model provides a liquid chromatograph or liquid chromatograph tandem mass spectrometer sample plate, includes the plate body, a plurality of sampling holes have been seted up on the plate body, be provided with sealing mechanism on the plate body, sealing mechanism includes the closing plate, the closing plate activity in on the plate body and right the sampling hole shelters from, a plurality of sampling holes have been seted up on the closing plate, the sampling hole can with the sampling hole intercommunication and along with the activity of closing plate make the sampling hole expose.
Through adopting above-mentioned technical scheme, when carrying out liquid detection, at first make sampling hole and sampling hole intercommunication with rotating the closing plate, then will wait to detect the sample and put in the sampling hole, then rotate the closing plate and make sampling hole and sampling hole dislocation, then put into the mass spectrometer with the plate body in, then rotatory closing plate detects, can reduce when installing into the model through the sealing mechanism who sets up, detect liquid and spill, reduce extravagant, can reduce simultaneously to operational environment's pollution for operational environment keeps clean, can reduce simultaneously and detect the volatilization of liquid.
Optionally, a clamping protrusion is formed on a side wall of the plate body away from the sealing plate, and the clamping protrusion can be connected with a rotating disc of the mass spectrometer.
Through adopting above-mentioned technical scheme, when detecting, the rolling disc drives the plate body and rotates for sampling hole on the plate body detects through gathering the end in proper order, and the joint of setting is protruding, makes the motion of plate body become stable.
Optionally, the sealing plate is rotated and is had the shrouding, set up the lofting hole on the shrouding, set up a plurality of intercommunications on the shrouding, a plurality of the intercommunicating pore respectively with a plurality of the sample hole corresponds, just the lofting hole is seted up in wherein two adjacent between the intercommunicating pore, the lofting hole with one of them when the sample hole communicates, the intercommunicating pore with the sample hole dislocation.
Through adopting above-mentioned technical scheme, when carrying out the liquid detection, the closing plate rotates and drives coupling assembling and rotate for lofting hole and one of them sample hole intercommunication, then detects, through above-mentioned setting, make at the in-process that detects, only one of them hole exposes, can reduce other volatilities of waiting to detect liquid, can reduce simultaneously and rotate the in-process, the spill of liquid, the waste of reduction detection liquid.
Optionally, the sealing plate is composed of a plurality of sealing rings which are sleeved in sequence and can rotate relatively, the sealing rings are all rotated on the plate body, each sealing ring is connected with the sealing plate in a rotating way, a plurality of sampling holes are all formed in the sealing rings, and the sampling holes are in one-to-one correspondence with the sampling holes; the sealing rings are provided with connecting assemblies, and a plurality of sealing rings synchronously rotate at intervals through the connecting assemblies.
Through adopting above-mentioned technical scheme, when carrying out liquid detection, the closing plate is rotated by a plurality of sealing rings and is constituteed for sealing ring accessible coupling assembling batch rotates, makes can hold more liquid of waiting to detect on the plate body, is convenient for wait to detect the detection of liquid, makes it hold more liquid of waiting to detect under the prerequisite that shelters from most sampling holes.
Optionally, the connecting assembly includes a connecting ring, a first synchronizing block and a second synchronizing block, the inner side of the sealing ring is provided with the connecting ring, the side wall of the outer side of the sealing ring, which is close to the inner side, is provided with a rotating hole, and the sealing ring is rotationally connected with the rotating hole of the adjacent sealing ring through the connecting ring; the rotating holes are internally provided with the first synchronizing blocks, the connecting rings are provided with the second synchronizing blocks, and the side walls of the second synchronizing blocks deviating from the rotating direction are abutted to the first synchronizing blocks.
By adopting the technical scheme, when the rotating disc drives the inner side sealing ring to rotate, the second synchronizing block is driven to rotate, the second synchronizing block is abutted against the first synchronizing block after rotating for a circle, the outer side sealing ring and the inner side sealing ring close to the outer side sealing ring are kept relatively static, and the innermost side sealing ring continues to rotate, so that the collecting end can sequentially detect liquid to be detected on the inner side; the connecting assembly is simple in structure, the inner sealing ring and the outer sealing ring synchronously rotate after rotating for one circle, the liquid to be detected is sequentially exposed, volatilization of the liquid to be detected is reduced, and sprinkling of the liquid to be detected is reduced.
Optionally, the sliding groove has been seted up on the shrouding, sliding in the sliding groove is connected with first stopper and second stopper, first stopper with the second stopper all set up in on the sealing ring, the second stopper with when sliding the lateral wall butt in groove, the lofting hole with the sampling hole intercommunication, first stopper with when sliding the lateral wall butt in groove, the intercommunicating pore with the sampling hole intercommunication.
Through adopting above-mentioned technical scheme, when treating to detect liquid, the rolling disc drives shrouding and inboard sealing ring and rotates, the second stopper and the groove butt that slides, make lofting hole and sampling hole intercommunication, the rolling disc continues to drive the sealing ring and rotates, inboard sealing ring and plate body synchronous rotation, make inboard sealing ring and plate body keep relatively static, realize lofting Kong Yici on the outside sealing ring and place the sampling hole intercommunication of treating to detect liquid, when adding to treat to detect liquid, reverse stir the sealing ring, first stopper and the groove butt that slides, the intercommunicating pore communicates with the sampling hole, then carry out the interpolation of treating to detect liquid, through above-mentioned setting, make the interpolation of treating to detect liquid and detect the convenience that becomes, and can realize the closure and the opening of a plurality of sampling holes, it is comparatively simple.
Optionally, a limiting snap ring is arranged on the sealing plate, and the limiting snap ring can be connected with the mass spectrometer to keep relatively static with the mass spectrometer.
Through adopting above-mentioned technical scheme, when the rolling disc drives the plate body motion, spacing snap ring is connected with the mass spectrometer for the plate body takes place relative rotation with the closing plate, realizes the switching of sampling hole, is convenient for gather the end and detects next, and spacing snap ring simple structure and convenient operation that set up can reduce manual operation and rotate the closing plate, and then makes the detection of waiting to detect liquid become convenient; can reduce the spilling of liquid and reduce the volatilization of liquid.
Optionally, an adjusting component is arranged on the sealing ring, the adjusting component comprises a sliding rod, and the sliding rod is connected with the first synchronizing block and can drive the first synchronizing block to slide along a direction away from the plate body.
By adopting the technical scheme, after all the liquid to be detected on the plate body is detected, the second synchronizing block is abutted with the side wall at the rear side of the rotating direction of the first synchronizing block, and in order to facilitate the resetting of the liquid to be detected, the sliding rod drives the first synchronizing block to slide so as to separate the first synchronizing block from the second synchronizing block, then the sealing ring is reversely rotated, and then the sliding rod is pressed so as to enable the side wall at the front side of the rotating direction of the first synchronizing block to be abutted with the second synchronizing block; the adjusting component who sets up simple structure, through adjusting component's setting, reduced the degree of difficulty that resets of sealing ring for wait to detect the convenience that the interpolation of liquid becomes.
Optionally, the adjusting component further comprises a reset spring, the seal rings are all provided with the reset springs, and the reset springs are connected with the first synchronous blocks and drive the first synchronous blocks to be located in the rotating holes all the time.
Through adopting above-mentioned technical scheme, reset spring drives first synchronizing block all the time and is located the rotation downthehole for the prescribing a limit to effect of first synchronizing block and second synchronizing block can be kept, and the liquid that makes the collection end gathers relatively stably.
In summary, the present application includes the following beneficial technical effects:
1. when liquid detection is carried out, the rotary sealing plate is firstly used for enabling the sampling hole to be communicated with the sampling hole, then a sample to be detected is placed in the sampling hole, then the rotary sealing plate is used for enabling the sampling hole to be staggered with the sampling hole, then the plate body is placed in the mass spectrometer, then the rotary sealing plate is used for detecting, and through the sealing mechanism, detected liquid can be prevented from being sprayed out when the sample plate is installed, waste is reduced, pollution to the working environment can be reduced, the working environment is kept clean, and volatilization of the detected liquid can be reduced;
2. when liquid to be detected is added, the sealing plate is reversely stirred, the first limiting block is abutted with the sliding groove, the communication hole is communicated with the sampling hole, then the liquid to be detected is added, through the arrangement, the liquid to be detected is added and the detection becomes convenient, and the sealing and opening of a plurality of sampling holes can be realized, so that the sealing is simpler;
3. when all the liquid to be detected on the plate body is detected, the second synchronizing block is abutted against the side wall at the rear side of the first synchronizing block in the rotating direction, and in order to facilitate the resetting of the liquid to be detected, the sliding rod drives the first synchronizing block to slide so as to separate the first synchronizing block from the second synchronizing block, then the sealing ring is reversely rotated, and then the sliding rod is pressed so as to enable the side wall at the front side of the first synchronizing block in the rotating direction to be abutted against the second synchronizing block; the adjusting component who sets up simple structure, through adjusting component's setting, reduced the degree of difficulty that resets of sealing ring for wait to detect the convenience that the interpolation of liquid becomes.
Drawings
FIG. 1 is a view of the mounting position of a plate in an embodiment of the present application;
FIG. 2 is a diagram of the mounting position of a limit snap ring in an embodiment of the present application;
FIG. 3 is an exploded view of a seal plate and a plate body according to an embodiment of the present disclosure;
FIG. 4 is a view of the mounting location of the seal plate in an embodiment of the present application;
FIG. 5 is a cross-sectional view of a first ring in an embodiment of the present application;
FIG. 6 is an enlarged view of A in FIG. 5;
FIG. 7 is an illustration of a slip groove in an embodiment of the present application;
FIG. 8 is an illustration of a rotary trough in an embodiment of the present application;
fig. 9 is an enlarged view of B in fig. 8.
Reference numerals: 100. a plate body; 110. a sampling hole; 200. a sealing mechanism; 210. a sealing plate; 211. a first ring; 212. a second ring; 213. a third ring; 214. a sampling hole; 215. a sliding hole; 216. sinking grooves; 217. a rotation hole; 218. a rotary groove; 219. a mounting groove; 220. a sealing plate; 221. a lofting hole; 222. a communication hole; 223. a slip groove; 230. a connection assembly; 231. a connecting ring; 232. a first synchronization block; 233. a second synchronization block; 240. a first limiting block; 250. a second limiting block; 260. a limiting snap ring; 270. an adjustment assembly; 271. a slide bar; 272. a reset spring; 273. a pull rod; 280. the clamping bulge; 300. a body; 400. and rotating the disc.
Detailed Description
The present application is described in further detail below in conjunction with fig. 1-9.
The liquid phase mass spectrometer comprises a body 300 and a rotating disc 400 which is rotatably arranged on the body 300, wherein the built-in drive of the body 300 is connected with the rotating disc 400, a plurality of supporting grooves for supporting sample feeding plates are formed in the rotating disc 400, the sample feeding plates are placed on the rotating disc 400, then the collecting end of the body 300 collects liquid to be detected on the sample feeding plates, and the position switching of the liquid to be detected and the collecting end is controlled through the rotation of the rotating disc 400.
The embodiment of the application discloses a liquid chromatograph or liquid chromatograph tandem mass spectrometer sample plate.
Referring to fig. 1, a sample injection plate for a liquid chromatograph or a liquid chromatograph tandem mass spectrometer comprises a plate body 100 detachably connected to a rotating disc 400 of the mass spectrometer and a sealing mechanism 200 arranged on the plate body 100, wherein a plurality of sampling holes 110 are formed in the plate body 100, the sealing mechanism 200 is used for controlling the communication between the sampling holes 110 and the outside, when a sample is detected, liquid to be detected is placed in the sampling holes 110, then the plate body 100 is placed on the rotating disc 400, then the communication between the sampling holes 110 and the outside is opened by the sealing mechanism 200, and then the detection is performed by the mass spectrometer.
Referring to fig. 2 and 3, the plate body 100 has a disc shape, and a plurality of sampling holes 110 are arranged at equal intervals along the circumferential direction of the plate body 100, and the sampling holes 110 are provided with a plurality of circles, preferably three circles in this application; the side wall of the plate body 100 far away from the sampling hole 110 is formed with a clamping protrusion 280, the clamping protrusion 280 is clamped with a bearing groove of the rotating disc 400, and the rotating disc 400 can drive the plate body 100 to rotate clockwise when the plate body 100 is overlooked.
Referring to fig. 4, 5 and 6, the sealing mechanism 200 includes a sealing plate 210, the sealing plate 210 is composed of a plurality of sealing rings, preferably three sealing rings, the three sealing rings are annular and are sequentially sleeved and freely rotate with each other, the three sealing rings are sequentially named as a first ring 211, a second ring 212 and a third ring 213, diameters of the first ring 211, the second ring 212 and the third ring 213 are sequentially reduced, a plurality of sampling holes 214 corresponding to the sampling holes 110 are formed in the first ring 211, the second ring 212 and the third ring 213, the plurality of sampling holes 214 are arranged at equal intervals along the circumferential direction of the sampling holes, and can be communicated with the sampling holes 110, and the third ring 213 is rotationally connected to the plate body 100; the sealing ring is provided with a connecting assembly 230, the connecting assembly 230 comprises two connecting rings 231 which are respectively and fixedly connected to the second ring 212 and the third ring 213, the side wall of the first ring 211, which is close to the inner side of the second ring 212, and the side wall of the second ring 212, which is close to the third ring 213, are respectively provided with rotating holes 217, and the two connecting rings 231 respectively rotate in the two rotating holes 217; the rotation hole 217 is fixedly connected with a first synchronization block 232, the connecting ring 231 is fixedly connected with a second synchronization block 233, and the second synchronization block 233 is abutted against the side wall of the first synchronization block 232 close to the rotation direction, namely the front side wall of the first synchronization block 232 in the clockwise direction; the outer side wall of the first ring 211 is fixedly connected with a limiting snap ring 260, the limiting snap ring 260 is connected with the mass spectrometer body 300, and when the rotating disc 400 drives the plate body 100 to rotate, the sealing ring and the mass spectrometer body 300 keep relatively static.
Referring to fig. 6, 7 and 8, the first ring 211, the second ring 212 and the third ring 213 are provided with a rotary groove 218 on the side wall close to the plate body 100, the rotary groove 218 is provided with a T-shaped groove along the circumferential direction and coaxial with the third ring 213, the section of the rotary groove 218 is an inverted T-shaped groove, the rotary groove 218 is rotationally connected with a sealing plate 220, the sealing plate 220 slightly protrudes from the sealing ring by about 0.3mm, the sealing plate 220 is abutted to the side wall of the plate body 100 far away from the rotary disc 400 and can rotate relatively with the side wall, the sealing plate 220 is provided with a plurality of communication holes 222, the communication holes 222 correspond to the sampling holes 214 and have the same size, and a lofting hole 221 is provided between two adjacent communication holes 222, when the lofting hole 221 is communicated with one of the sampling holes 110, the communication holes 222 are staggered with the sampling holes 214, so that the lofting hole 221 is blocked; in order to facilitate the sealing plate 220 to always seal other sampling holes 214 in the sampling process, a sliding groove 223 is formed in the side wall of the sealing plate 220, which is positioned on the inner side and the outer side of the rotary groove 218, a first limiting block 240 and a second limiting block 250 are slidably connected in the sliding groove 223, the first limiting block 240 and the second limiting block 250 are fixedly connected with the inner wall of the rotary groove 218, the second limiting block 250 is positioned on one side of the first limiting block 240 in the anticlockwise direction, when the second limiting block 250 is abutted against the side wall of the sliding groove 223, which deviates from the rotation direction, the lofting hole 221 is communicated with one of the sampling holes 214, and the sealing plate 220 seals other sampling holes 110; when the first limiting block 240 abuts against the side wall of the front side of the sliding groove 223 in the rotation direction, the communication hole 222 is communicated with the sampling hole 214, and the rotary sealing ring can enable the sampling hole 214 to be communicated with the lofting hole 221, so that the liquid to be detected can be conveniently added.
Referring to fig. 8 and 9, in order to facilitate resetting of the seal ring after the detection is finished, sliding holes 215 communicated with the rotating holes 217 are formed in the first ring 211 and the second ring 212, an adjusting assembly 270 is arranged on the seal ring, the adjusting assembly 270 comprises a sliding rod 271 which is slidingly connected in the sliding holes 215 along the vertical direction, a pull rod 273 is fixedly connected to the sliding rod 271, a sinking groove 216 is formed in each of the first ring 211 and the second ring 212, the pull rod 273 is sunk into the sinking groove 216, and a hand pinching groove which is convenient to grasp is formed in the side wall of the sinking groove 216; the rotation hole 217 is provided with a mounting groove 219 communicated with the sliding hole 215, the first synchronizing block 232 can slide along the mounting groove 219, a reset spring 272 is fixedly connected in the mounting groove 219, and the reset spring 272 is connected with the first synchronizing block 232 and has the potential of pushing the first synchronizing block 232 to be positioned in the rotation hole 217. After the first ring 211 and the second ring 212 are rotated and misplaced for one turn, the side wall of the first synchronizing block 232 far away from the rotation direction is abutted against the second synchronizing block 233, the pull rod 273 is pulled, the pull rod 273 drives the first synchronizing block 232 to retract into the mounting groove 219, then the first ring 211 is rotated, the second synchronizing block 233 passes over the first synchronizing block 232, then the pull rod 273 is released, the reset spring 272 drives the first synchronizing block 232 to enter the rotation hole 217, and the side wall of the front side of the first synchronizing block 232 in the rotation direction is abutted against the second synchronizing block 233.
The implementation principle of the sample plate of the liquid chromatograph or the liquid chromatograph tandem mass spectrometer in the embodiment of the application is as follows: firstly, the sealing plate 220 is slid so that the first limiting block 240 is abutted with the sliding groove 223, the communication hole 222 is communicated with the sampling hole 214, then the sealing plate 210 is rotated so that the sampling hole 214 is communicated with the sampling hole 110, and then liquid to be detected is sequentially added into the sampling hole 110; or the sliding sealing plate 220 is used for enabling the second limiting block 250 to be abutted with the sliding groove 223, then liquid to be detected is added into the sampling hole 110 in sequence, and splashing and mixing of the liquid are reduced; the seal plate 220 is then rotated so that the loft holes 221 communicate with the sampling holes 214, and the plate body 100 is then placed on the rotating disc 400.
The limiting snap ring 260 is connected with the mass spectrometer body 300, then the rotating disc 400 drives the plate body 100 to rotate, and the plate body 100 and the first ring 211 are relatively displaced, so that the sampling holes 110 are sequentially communicated with the sampling holes 214, and sampling is completed; after the first ring 211 and the plate body 100 relatively move for one circle, the side wall of the first synchronizing block 232 far away from the rotation direction is abutted against the second synchronizing block 233, then the second ring 212 is relatively static relative to the first ring 211, and the plate body 100 and the second ring 212 relatively rotate, so that the lofting holes 221 on the second ring 212 are sequentially communicated with the sampling holes 110; after one rotation of the second ring 212 relative to the plate 100, the third ring 213 is stationary relative to the second ring 212.
After the detection is finished, the plate body 100 is taken down, then the pull rod 273 is pulled, the pull rod 273 drives the first synchronizing block 232 to retract into the mounting groove 219, then the first ring 211 is rotated, the second synchronizing block 233 passes over the first synchronizing block 232, then the pull rod 273 is released, the reset spring 272 drives the first synchronizing block 232 to enter the rotating hole 217, and the side wall of the front side of the rotating direction of the first synchronizing block 232 is abutted with the second synchronizing block 233; the addition of the liquid to be tested is then performed by rotating the closure plate 220 to achieve a multi-well joint or single addition of the liquid to be tested.
The foregoing are all preferred embodiments of the present application, and are not intended to limit the scope of the present application in any way, therefore: all equivalent changes in structure, shape and principle of this application should be covered in the protection scope of this application.
Claims (9)
1. The utility model provides a liquid chromatograph or liquid chromatograph tandem mass spectrometer sample plate, includes plate body (100), a plurality of sampling holes (110) have been seted up on plate body (100), a serial communication port, be provided with sealing mechanism (200) on plate body (100), sealing mechanism (200) include closing plate (210), closing plate (210) activity in on plate body (100) and right sampling holes (110) are sheltered from, a plurality of sampling holes (214) have been seted up on closing plate (210), sampling holes (214) can with sampling holes (110) intercommunication and along with the activity of closing plate (210) make sampling holes (110) expose.
2. The liquid chromatograph or liquid chromatograph tandem mass spectrometer sample plate according to claim 1, characterized in that a clamping protrusion (280) is formed on a side wall of the plate body (100) away from the sealing plate (210), and the clamping protrusion (280) is connectable with a rotating disc (400) of the mass spectrometer.
3. The liquid chromatograph or liquid chromatograph tandem mass spectrometer sample plate according to claim 1, characterized in that a sealing plate (220) is rotated on the sealing plate (210), a sample hole (221) is formed in the sealing plate (220), a plurality of communication holes (222) are formed in the sealing plate (220), the plurality of communication holes (222) respectively correspond to the plurality of sample holes (214), the sample hole (221) is formed between two adjacent communication holes (222), and when the sample hole (221) is communicated with one of the sample holes (214), the communication holes (222) are dislocated with the sample holes (214).
4. A liquid chromatograph or a liquid chromatograph tandem mass spectrometer sample plate according to claim 3, wherein the sealing plate (210) is composed of a plurality of sealing rings which are sleeved in turn and can rotate relatively, the sealing rings are all rotated on the plate body (100), each sealing ring is rotationally connected with the sealing plate (220), a plurality of sampling holes (214) are all arranged on the sealing rings, and the sampling holes (214) are in one-to-one correspondence with the sampling holes (110); the sealing rings are provided with connecting assemblies (230), and a plurality of sealing rings synchronously rotate at intervals through the connecting assemblies (230).
5. The liquid chromatograph or liquid chromatograph tandem mass spectrometer sample plate according to claim 4, characterized in that the connecting component (230) comprises a connecting ring (231), a first synchronizing block (232) and a second synchronizing block (233), the connecting rings (231) are arranged on the inner sealing rings, a rotating hole (217) is formed on the side wall, close to the inner sealing ring, of the outer sealing ring, and the sealing rings are rotationally connected with the rotating holes (217) of the adjacent sealing rings through the connecting rings (231); the rotating holes (217) are internally provided with first synchronizing blocks (232), the connecting ring (231) is provided with second synchronizing blocks (233), and the side walls of the second synchronizing blocks (233) deviating from the rotating direction are abutted to the first synchronizing blocks (232).
6. The liquid chromatograph or liquid chromatograph tandem mass spectrometer sample plate according to claim 4, wherein a sliding groove (223) is formed in the sealing plate (220), a first limiting block (240) and a second limiting block (250) are slidably connected in the sliding groove (223), the first limiting block (240) and the second limiting block (250) are both arranged on the sealing ring, when the second limiting block (250) is abutted to the side wall of the sliding groove (223), the sample placing hole (221) is communicated with the sampling hole (214), and when the first limiting block (240) is abutted to the side wall of the sliding groove (223), the communication hole (222) is communicated with the sampling hole (214).
7. The liquid chromatograph or liquid chromatograph tandem mass spectrometer sample plate according to claim 2, characterized in that a limit snap ring (260) is provided on the sealing plate (210), said limit snap ring (260) being connectable to the mass spectrometer to remain relatively stationary with respect to the mass spectrometer.
8. The liquid chromatograph or liquid chromatograph tandem mass spectrometer sample plate according to claim 5, characterized in that an adjusting component (270) is provided on the sealing ring, the adjusting component (270) comprises a sliding rod (271), and the sliding rod (271) is connected with the first synchronization block (232) and can drive the first synchronization block (232) to slide in a direction away from the plate body (100).
9. The liquid chromatograph or liquid chromatograph tandem mass spectrometer sample plate according to claim 8, wherein said adjusting assembly (270) further comprises a return spring (272), said return springs (272) are provided on said seal rings, said return springs (272) are connected with said first synchronization blocks (232) and drive said first synchronization blocks (232) to be always located in said rotation holes (217).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311264887.0A CN117269385B (en) | 2023-09-27 | 2023-09-27 | Sample injection plate of liquid chromatograph tandem mass spectrometer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311264887.0A CN117269385B (en) | 2023-09-27 | 2023-09-27 | Sample injection plate of liquid chromatograph tandem mass spectrometer |
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| Publication Number | Publication Date |
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| CN117269385A true CN117269385A (en) | 2023-12-22 |
| CN117269385B CN117269385B (en) | 2024-05-14 |
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| CN202311264887.0A Active CN117269385B (en) | 2023-09-27 | 2023-09-27 | Sample injection plate of liquid chromatograph tandem mass spectrometer |
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| CN113019480A (en) * | 2021-04-19 | 2021-06-25 | 青岛市疾病预防控制中心（青岛市预防医学研究院） | Sample transportation equipment for preventive medicine with heat preservation effect |
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| CN219715347U (en) * | 2022-09-26 | 2023-09-19 | 中国农业科学院油料作物研究所 | Sample feeding disc for online detection of cell metabolites by flow cytometry and chromatograph |
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| CN112525612A (en) * | 2020-12-21 | 2021-03-19 | 辽宁科技学院 | Liquid sampling device and method capable of being sealed annularly for chemical detection |
| CN113019480A (en) * | 2021-04-19 | 2021-06-25 | 青岛市疾病预防控制中心（青岛市预防医学研究院） | Sample transportation equipment for preventive medicine with heat preservation effect |
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| CN216646377U (en) * | 2021-12-17 | 2022-05-31 | 郑州和合医学检验实验室有限公司 | Liquid chromatography tandem mass spectrometer sample feeding plate |
| CN217278119U (en) * | 2022-04-12 | 2022-08-23 | 南京天嘉检测服务有限公司 | Liquid chromatogram or liquid chromatogram tandem mass spectrometer sample introduction plate |
| CN217717640U (en) * | 2022-05-31 | 2022-11-01 | 安徽环轩材料科技有限公司 | Low-position automatic sample injector capable of carrying out temperature protection on samples |
| CN219715347U (en) * | 2022-09-26 | 2023-09-19 | 中国农业科学院油料作物研究所 | Sample feeding disc for online detection of cell metabolites by flow cytometry and chromatograph |
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| CN117269385B (en) | 2024-05-14 |
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