CN1172610C - Poison reducing additive for zhangguo cigarette and its preparing method - Google Patents
Poison reducing additive for zhangguo cigarette and its preparing method Download PDFInfo
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- CN1172610C CN1172610C CNB011019638A CN01101963A CN1172610C CN 1172610 C CN1172610 C CN 1172610C CN B011019638 A CNB011019638 A CN B011019638A CN 01101963 A CN01101963 A CN 01101963A CN 1172610 C CN1172610 C CN 1172610C
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- cigarette
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- green tea
- radix glycyrrhizae
- honeysuckle
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- 239000000654 additive Substances 0.000 title claims abstract description 51
- 230000000996 additive effect Effects 0.000 title claims abstract description 51
- 235000019504 cigarettes Nutrition 0.000 title claims abstract description 51
- 231100000614 poison Toxicity 0.000 title abstract 4
- 239000002574 poison Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title description 7
- 244000248162 Xanthoceras sorbifolium Species 0.000 claims abstract description 15
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 14
- 244000269722 Thea sinensis Species 0.000 claims abstract description 14
- 235000009569 green tea Nutrition 0.000 claims abstract description 14
- 241000722949 Apocynum Species 0.000 claims description 13
- 244000037364 Cinnamomum aromaticum Species 0.000 claims description 13
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims description 13
- 241000721690 Lythrum salicaria Species 0.000 claims description 13
- 235000004347 Perilla Nutrition 0.000 claims description 13
- 241000229722 Perilla <angiosperm> Species 0.000 claims description 13
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 238000005303 weighing Methods 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 6
- 238000010298 pulverizing process Methods 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- 238000005352 clarification Methods 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
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- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000035800 maturation Effects 0.000 claims description 2
- 241000208125 Nicotiana Species 0.000 abstract description 25
- 235000002637 Nicotiana tabacum Nutrition 0.000 abstract description 25
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract description 10
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract description 8
- 230000000711 cancerogenic effect Effects 0.000 abstract description 8
- 229960002715 nicotine Drugs 0.000 abstract description 8
- 239000000126 substance Substances 0.000 abstract description 8
- 231100000315 carcinogenic Toxicity 0.000 abstract description 7
- 239000003205 fragrance Substances 0.000 abstract description 7
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract description 4
- 229930195733 hydrocarbon Natural products 0.000 abstract description 4
- 150000002430 hydrocarbons Chemical class 0.000 abstract description 4
- 201000005202 lung cancer Diseases 0.000 abstract description 4
- 208000020816 lung neoplasm Diseases 0.000 abstract description 4
- 238000002360 preparation method Methods 0.000 abstract description 4
- 206010064571 Gene mutation Diseases 0.000 abstract description 3
- 239000002243 precursor Substances 0.000 abstract description 3
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract description 2
- XKLJHFLUAHKGGU-UHFFFAOYSA-N nitrous amide Chemical compound ON=N XKLJHFLUAHKGGU-UHFFFAOYSA-N 0.000 abstract description 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 2
- 241000185686 Apocynum venetum Species 0.000 abstract 1
- FMMWHPNWAFZXNH-UHFFFAOYSA-N Benz[a]pyrene Chemical compound C1=C2C3=CC=CC=C3C=C(C=C3)C2=C2C3=CC=CC2=C1 FMMWHPNWAFZXNH-UHFFFAOYSA-N 0.000 abstract 1
- 206010007269 Carcinogenicity Diseases 0.000 abstract 1
- UYYRKEKHAYEACU-UHFFFAOYSA-N Flavocol Natural products CC(C)CC1=CN=C(CC(C)C)C(=O)N1 UYYRKEKHAYEACU-UHFFFAOYSA-N 0.000 abstract 1
- 241000219991 Lythraceae Species 0.000 abstract 1
- 235000009240 Xanthoceras sorbifolium Nutrition 0.000 abstract 1
- 231100000260 carcinogenicity Toxicity 0.000 abstract 1
- 230000007670 carcinogenicity Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000003505 mutagenic effect Effects 0.000 abstract 1
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- 239000000463 material Substances 0.000 description 9
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 7
- 239000011269 tar Substances 0.000 description 7
- MVOSYKNQRRHGKX-UHFFFAOYSA-N 11-Undecanolactone Chemical compound O=C1CCCCCCCCCCO1 MVOSYKNQRRHGKX-UHFFFAOYSA-N 0.000 description 6
- 150000002596 lactones Chemical group 0.000 description 6
- -1 phthalic acid ester Chemical class 0.000 description 6
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical class CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 5
- XNGIFLGASWRNHJ-UHFFFAOYSA-N o-dicarboxybenzene Natural products OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 5
- 238000003672 processing method Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
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- 239000000567 combustion gas Substances 0.000 description 3
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- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
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- 231100000357 carcinogen Toxicity 0.000 description 2
- 239000003183 carcinogenic agent Substances 0.000 description 2
- 239000011285 coke tar Substances 0.000 description 2
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 150000004702 methyl esters Chemical class 0.000 description 2
- 150000002825 nitriles Chemical class 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
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- 239000000047 product Substances 0.000 description 2
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- 229940031439 squalene Drugs 0.000 description 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
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- MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 description 1
- 229930195730 Aflatoxin Natural products 0.000 description 1
- 208000031404 Chromosome Aberrations Diseases 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 241001464837 Viridiplantae Species 0.000 description 1
- YQUSWNHGXVVZQZ-UHFFFAOYSA-N [C](Cl)Cl.N1=CC=CC(=C1)C1N(C)CCC1 Chemical compound [C](Cl)Cl.N1=CC=CC(=C1)C1N(C)CCC1 YQUSWNHGXVVZQZ-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
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- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 239000005409 aflatoxin Substances 0.000 description 1
- 238000005575 aldol reaction Methods 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 231100000005 chromosome aberration Toxicity 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
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- 229940079593 drug Drugs 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
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- 239000000284 extract Substances 0.000 description 1
- 238000002309 gasification Methods 0.000 description 1
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- CLTXFEAAEJABQN-UHFFFAOYSA-N heptane-1,1,1-triol Chemical compound CCCCCCC(O)(O)O CLTXFEAAEJABQN-UHFFFAOYSA-N 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 231100000567 intoxicating Toxicity 0.000 description 1
- 230000002673 intoxicating effect Effects 0.000 description 1
- 150000002561 ketenes Chemical class 0.000 description 1
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- 238000001819 mass spectrum Methods 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
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- IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical compound CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
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- 150000005846 sugar alcohols Polymers 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7221—Determining signal validity, reliability or quality
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/0245—Detecting, measuring or recording pulse rate or heart rate by using sensing means generating electric signals, i.e. ECG signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/251—Means for maintaining electrode contact with the body
- A61B5/252—Means for maintaining electrode contact with the body by suction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/276—Protection against electrode failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
- A61B5/282—Holders for multiple electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
- A61B5/339—Displays specially adapted therefor
- A61B5/341—Vectorcardiography [VCG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
- A61B5/6804—Garments; Clothes
- A61B5/6805—Vests
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6843—Monitoring or controlling sensor contact pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0484—Garment electrodes worn by the patient
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Physiology (AREA)
- Signal Processing (AREA)
- Artificial Intelligence (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Psychiatry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a poison reducing additive for cigarette, which is prepared from yellow horn, honeysuckle flower, Folium Perillae, Apocynum venetum L., Ramulus Cinnamomi, loosestrife, green tea and Radix Glycyrrhizae according to a certain proportion; the additive can be powder, aqueous agent, solution or chopping to be mixed in tobacco shreds, preferably the solution; the additive contains the effective substances such as Pyran derivative, polycyclic olefine hydrocarbon, etc., which can cause nicotine in the cigarette to open loop so as to generate non-poisonous compounds; in a technological line, the additive of 50 % content is sprayed on the tobacco shreds according to the proportion of 1 to 2 %; the additive plays the function before burning so as to eliminate and stop the synthesis of carcinogenicity carcinogenic precursor substances consequently so as to reduce the tar content of the cigarette; the additive has strong bioactivity of anti-gene mutation, can weaken the mutagenic action of strong carcinogenic substances, such as benzopyrene, nitrosamine, flavacol, etc. and can restrain lung cancer induced by the hydrocarbon substances of the tobacco. In addition, the additive can obviously improve the fragrance of the cigarette; besides, the present invention also provides the preparation method of the poison reducing additive for cigarette.
Description
Technical field
The present invention relates to a kind of cigarette attenuation additive, particularly, be a kind of be that the natural vegetable Chinese herbal medicine of primary raw material is prepared from cigarette additive with shiny-leaved yellowhorn (camphor tree fruit); The invention still further relates to the preparation method of this cigarette attenuation additive.
Technical background
The treatment that the World Health Organization announces shows: tobacco can cause 25 kinds of life-threatening diseases, the first-selected lung cancer that fatal rate is the highest, and number with the tobacco relevant disease is died from up to 3,500,000 people in the annual whole world.However, owing to social cause with suck reason such as custom, cigarette is as a kind of " gentle drugs ", and eradicating it fully also needs a very long process.The whole world still has 1,100,000,000 smokers according to incompletely statistics, and there are 3.2 hundred million smokers in China.So how to alleviate the hazard to person that cigarette brings to greatest extent, be the target that the tobacco researcher pursues always.Show that through a large amount of scientific researches it is strong carcinogens such as three in the tar, four BaPs that tobacco is caused " the black killer " of gene mutation, chromosome aberration.Therefore each big tobacco handle reduces cigarette tar content as preferred object in the world.The burnt means of having taked of falling all are physical method,, lengthening filter tip expanded as laser boring, pipe tobacco etc.The use of these means, fund input is bigger, owing to changed fragrance and the strength of tobacco, makes that the cigarette market sale is undesirable.In recent years, the someone attempts solving coke tar in cigarette carcinogenic toxicity problem with Chinese herbal medicine, because Chinese medicine and the process route selected mix pipe tobacco when cigarette burning, pharmacological action is with regard to total loss.This is to adopt plant additive to solve a key technology difficult problem of cigarette coke tar carcinogenic toxicity problem, and in addition, some additive has also destroyed the individual character taste of cigarette, influences market sale, is difficult to cigarette factory and accepts.At the problems referred to above, the inventor was through the arduous exploration in 8 years, and repetition test is developed the cigarette that overcomes above-mentioned defective finally and fallen malicious additive.
Summary of the invention
Goal of the invention of the present invention just provides a kind of cigarette attenuation additive, and this additive can effectively reduce toxic component in the cigarette, and adds to act on when pipe tobacco burns in the cigarette and can not lose, and in addition, has kept the fragrance of cigarette.
The present invention realizes goal of the invention like this:
The present invention has selected three class plants on raw material, it is the biosynthesis that first kind plant material can be blocked carcinogenic precursor substance in the cigarette, be sprayed onto on the pipe tobacco, before burning, just work, when sucking, in the main flume that enters human body that cigarette burning produces, the carcinogen of energy modificator gene sudden change significantly reduces, thereby suppressed the lung cancer morbidity probability that the tobacco hydrocarbons is brought out, this is a key point of the present invention; The second class plant material produces in can the main flume when cigarette burning has gasification substance clearing heat and detoxicating, relieving cough and reducing sputum effect, and this class plant is only worked when burning; The 3rd class plant is mainly used to improve the fragrance of cigarette, make it gentle in energetically, fragrance is pure, has the natural fragrance of the Nature green plants.Therefore, to fall malicious additive be to be made by three class plant materials of following consumption to cigarette of the present invention:
Shiny-leaved yellowhorn 40-60%, honeysuckle 10-30%, perilla leaf 10-30%, bluish dogbane 2-6%, cassia twig 2-6%, Lythrum salicaria 2-6%, green tea 2-6%, Radix Glycyrrhizae 2-6%.
Be preferably:
Shiny-leaved yellowhorn 40-50%, honeysuckle 15-25%, perilla leaf 15-25%, bluish dogbane 3-5%, cassia twig 3-5%, Lythrum salicaria 3-5%, green tea 3-5%, Radix Glycyrrhizae 3-5%.
The best is:
Shiny-leaved yellowhorn 40%, honeysuckle 20%, perilla leaf 20%, bluish dogbane 4%, cassia twig 4%, Lythrum salicaria 4%, green tea 4%, Radix Glycyrrhizae 4%.
It can be that pulvis, aqua, solution or chopping are mixed in the pipe tobacco that malicious additive falls in cigarette of the present invention.Wherein when this additive was pulvis, dilute with water directly used its spray on pipe tobacco; Perhaps chopping is directly mixed in the pipe tobacco according to the ratio of 10-30%; Also above-mentioned raw materials can be made solution according to common process is sprayed on the pipe tobacco.Most preferably above-mentioned raw materials is handled respectively according to its different qualities, be mixed and made into solution then.Concrete technology is as follows:
A) selecting shiny-leaved yellowhorn for use is fresh ripening fruits, cleans, squeezes the juice according to formula rate, filters, and the bright juice of getting clarification is standby;
B) with honeysuckle, perilla leaf, Lythrum salicaria, green tea according to prescription weighing, cleaning, pulverizing, with 100 ℃ of water loggings bubbles 24 hours, filtration was left standstill 12-24 hour, got supernatant, it is standby less than 50% concentrate to be concentrated to concentration;
C) with bluish dogbane, cassia twig, Radix Glycyrrhizae according to the formula ratio weighing, cleaning, pulverizing, water decocted 2 hours at 100 ℃, filtered, and filter residue was decocted 1 hour again, filtered, and merged twice filtrate and left standstill 12-24 hour, got supernatant, were concentrated to 50%, and be standby;
D) merge above-mentioned three kinds of juices, mix, filter, sterilization.
The main pharmacological function that malicious additive falls in cigarette of the present invention is the nicotine open loop that can make in the cigarette, generate non-toxic compound, block the synthetic of carcinogenic precursor substance, reduce cigarette tar content, biologically active with very strong anti-gene mutation, strong carcinogenic mutagenesis such as BaP, nitrosamine, aflatoxins can be weakened, the lung cancer that the tobacco hydrocarbons is brought out can be suppressed.In addition, this additive also can obviously improve the fragrance of cigarette.Show that the maximal tolerance dose of additive of the present invention is in 40ml stoste/more than the kg body weight through acute toxicity test.After cigarette of the present invention fell and uses in the malicious additive adding cigarette, sample detected through national tobacco quality supervision and inspection center, and tar content drops to 17.2mg by 21.8mg, descends 21%; Nicotine content in smoke drops to 1.04mg by 1.54mg, descends 33%.Simultaneously, smoke panel test, consistently think that pilot sample can be given prominence to this perfume (or spice) of tobacco, does not have peculiar smell, compare more pure in the same old way and fragrant through the committee member that smokes panel test.
Below by test the example and embodiment describe the present invention in detail.
The specific embodiment
The detoxifcation test to oil smoke of malicious additive falls in test example 1 cigarette
1) test apparatus and medicine:
5890IIGC/HP 5971A MSD
Dichloroethanes is analyzed pure
Malicious additive falls in cigarette of the present invention
Tobacco tar
2) processing method of test specimen:
The additive of the present invention that takes a morsel is dissolved in the 10ml dichloroethanes, makes the dichloroethane solution of additive of the present invention;
The tobacco tar that takes a morsel is dissolved in the 10ml dichloroethanes, makes the oil smoke dichloroethane solution.
3) experimental condition:
GC condition: T
Injection=250 ℃ of T
Measure=280 ℃
Temperature programming: 60 ℃ (1 minute) 10 ℃/minute 280 ℃ (10 minutes)
Sample size: 1 μ L.
4) result of the test:
A. additive of the present invention contains following material: heptan triol, withered crust alkene, cyclenes, carypohyllene, α-carypohyllene, naphthalene ene derivative, undecalactone, 2, the two trimethyl silicane benzoic acid trimethylsilyl groups of 5-, 17 alkene-1, hexadecanoyl, phthalic acid ester, margarone-2, dibutyl phthalate, arbricolin, some unsaturated cyclenes alcohol, polyalcohol and polynary cyclic hydrocarbon etc.;
B. oil smoke contains following material: p-methyl phenol, 3-(1-methyl-2-pyrrolidinyl) pyridine, 3-(1-methyl isophthalic acid H-pyrroles) pyridine, 2,2 '-two pyridines, phthalic acid ester, some highly unsaturated ketenes, unsaturated annulenones, unsaturated cyclopolyol, polynary cyclic alcohol and the polynary cyclenes ester of unsaturated acetate.
C. additive solution of the present invention is analyzed immediately with after the oil smoke sample solution mixes, and the gained chromatogram is the stack of two kinds of material chromatograms substantially; Sample introduction after 45 minutes, from collection of illustrative plates, undecalactone, hexadecanoyl and arbricolin begin to reduce; Sample introduction after 3 hours, from collection of illustrative plates, undecalactone, hexadecanoyl and arbricolin complete obiteration, and 2, the two trimethyl silicane benzoic acid trimethylsilyl groups of 5-, margarone-2, phthalic acid ester, ethylenic unsaturation lactone, alkyl substituted ring lactone and the basic disappearance of unsaturated cyclenes alcohol.
5) interpretation of result:
From The above results as can be seen, additive solution of the present invention is with after the oil smoke sample solution mixes, undecalactone in the additive solution of the present invention, hexadecanoyl, arbricolin, 2, the two trimethyl silicane benzoic acid trimethylsilyl groups of 5-, margarone-2, phthalic acid ester, ethylenic unsaturation lactone, alkyl substituted ring lactone and unsaturated cyclenes ester disappear from spectrogram, it can be said that the bright chemical reaction that taken place between the two.Because the awkward volatile materials of a product part, another part is the material of highly volatile, under this chromatogram test condition, this part can not detected, so there is not the novel substance peak to occur on chromatogram.Analyze contingent chemical reaction, mainly contain two aspects: the one, all awkward exemplary volatile weak base organic compound of the main component in the oil smoke sample, they can be with 2, the 5 pairs of trimethyl silicane benzoic acid trimethylsilyl groups, phthalic acid ester, ethylenic unsaturation lactone, alkyl substituted ring lactone generation ester generate difficult volatility ester and volatile alcohol for reaction; The 2nd, under the condition that the alkalescent material in oil smoke exists, aldol reaction can take place in chain alkyl ether and ketone, generates difficult volatile long-chain compound.
The detoxifcation test to tobacco of malicious additive falls in test example 2 cigarette
1) test apparatus and medicine:
5890 chromatographs and 5972 little mass spectrographs (hewlette-packard production)
Carrene (analyzing pure)
Additive of the present invention
Cigarette (commercially available)
2) processing method of test specimen:
(i) processing method of cigarette sample
The 10ml carrene is added in the absorption bottle, and with a termination vavuum pump of absorption bottle, another termination is removed filter-tip cigarette, and the dichloromethane solution that absorbs after 5 cigarettes is a sample 1, and its color is a dark-brown.
The (ii) processing method of additive of the present invention
Get additive solution of the present invention and be added in the 5ml carrene, fully mix the back standing demix, the organic layer that takes off face is a sample 2.
The (iii) processing method of tobacco combustion gas solution and additive reaction blend sample of the present invention
Get 1ml sample 1 and 1ml sample 2 and put into test tube and fully mix, leave standstill 5 minutes after, be sample 3.
Above-mentioned three kinds of samples are carried out chromatograph mass spectrum analysis.
3) result of the test:
A. the main component of cigarette combustion gas is a nicotine.
B. the main component of additive of the present invention is pyran derivate, polycyclic olefin.In addition, its composition also has: undecalactone, arbricolin, plant acid methyl esters, squalene, 4,8,12-trimethyl-3,7,11-triolefin-13 nitrile.
C. the product of cigarette combustion gas and additive of the present invention may be: undecalactone, arbricolin, plant acid methyl esters, squalene, 4,8,12-trimethyl-3,7,11-triolefin-13 nitrile.
4) conclusion: additive of the present invention can make the nicotine open loop in the cigarette, generates non-toxic compound, thereby plays detoxication.
Test example 3: additive of the present invention is to the detoxication of poisoning animal
1) test article:
That a. extracts from cigarette contains nicotine solution-dichloromethane solution
B. additive solution of the present invention
2) test method:
The dichloromethane solution that at first will contain nicotine splashes in the small white mouse mouth, and about 6 altogether of front and back slowly rotate the small white mouse original place of normal growth, fall down then, and the twitch state is arranged.Drip the about 3-5 of additive solution of the present invention this moment, splashes in the small white mouse mouth, and small white mouse was slowly stood after about 10 seconds, walked about then.Through repetition test, effect is apparent in view.The results are shown in Table 1.
Table 1
| Test number (TN) | The nicotine carbon dichloride solution amount of splashing into | The abnormal time (second) of animal | The additive solution amount of splashing into of the present invention | Reply the normality time (second) | Remarks |
| 1 | 4 | Ametaboly | The 1st | ||
| 2 | 2 | 10 | 5 | 1 1 | The 1st |
| 3 | 7 | 7 | 4 | 15 | The 2nd |
| 4 | 6 | 8 | 3 | 10 | The 3rd |
| 5 | 5 | Ametaboly | The 4th | ||
| 6 | 5 | 8 | 4 | 9 | The 4th |
| 7 | 6 | 8 | 3 | 10 | The 5th |
| 8 | 7 | 10 | 4 | 10 | The 6th |
| 9 | 6 | 7 | 3 | 9 | The 7th |
| 10 | 6 | 8 | 3 | 10 | The 8th |
3) conclusion: this animal experiment 8 times repeatedly, effect have proved fully that as one additive solution of the present invention has obviously, directly dissolves effect to the intoxicating phenomenon that nicotine, tar produced in the cigarette.
The preparation of malicious additive solution falls in embodiment 1 cigarette
A) take by weighing raw material according to following prescription: shiny-leaved yellowhorn 40g, honeysuckle 20g, perilla leaf 20g, bluish dogbane 4g, cassia twig 4g, Lythrum salicaria 4g, green tea 4g, Radix Glycyrrhizae 4g;
B) select the shiny-leaved yellowhorn of fresh maturation for use, clean, squeeze the juice according to formula rate, filter, the bright juice of getting clarification is standby;
C) with honeysuckle, perilla leaf, Lythrum salicaria, green tea according to prescription weighing, cleaning, pulverizing, with 100 ℃ of water loggings bubbles 24 hours, filtration was left standstill 24 hours, got supernatant, the concentrate that is concentrated to concentration 40-50% is standby;
D) with bluish dogbane, cassia twig, Radix Glycyrrhizae according to the formula ratio weighing, cleaning, pulverizing, water decocted 2 hours at 100 ℃, filtered, and filter residue was decocted 1 hour again, filtered, and merged twice filtrate and left standstill 24 hours, got supernatant, were concentrated to 50%, and be standby;
E) merge above-mentioned three kinds of juices, mix, sterilization promptly becomes white emulsion.
Embodiment 2
According to the method described in the embodiment 1, with the prescription in the following prescription alternate embodiment 1: shiny-leaved yellowhorn 50g, honeysuckle 30g, perilla leaf 10g, bluish dogbane 2g, cassia twig 2g, Lythrum salicaria 2g, green tea 2g, Radix Glycyrrhizae 2g.
Embodiment 3
According to the method described in the embodiment 1, with the prescription in the following prescription alternate embodiment 1: shiny-leaved yellowhorn 60g, honeysuckle 10g, perilla leaf 10g, bluish dogbane 2g, cassia twig 2g, Lythrum salicaria 2g, green tea 2g, Radix Glycyrrhizae 2g.
Embodiment 4
According to the method described in the embodiment 1, with the prescription in the following prescription alternate embodiment 1: shiny-leaved yellowhorn 40g, honeysuckle 20g, perilla leaf 15g, bluish dogbane 5g, cassia twig 5g, Lythrum salicaria 5g, green tea 5g, Radix Glycyrrhizae 5g.
Claims (4)
1, malicious additive falls in a kind of cigarette, and it is to be made by the raw material of following percentage by weight consumption:
Shiny-leaved yellowhorn 40-60%, honeysuckle 10-30%, perilla leaf 10-30%, bluish dogbane 2-6%, cassia twig 2-6%, Lythrum salicaria 2-6%, green tea 2-6%, Radix Glycyrrhizae 2-6%.
2, according to claim 1 is described malicious additive falls, wherein: shiny-leaved yellowhorn 40-50%, honeysuckle 15-25%, perilla leaf 15-25%, bluish dogbane 3-5%, cassia twig 3-5%, Lythrum salicaria 3-5%, green tea 3-5%, Radix Glycyrrhizae 3-5%, described percentage is weight percentage.
3, fall malicious additive according to claim 2 is described, wherein: shiny-leaved yellowhorn 40%, honeysuckle 20%, perilla leaf 20%, bluish dogbane 4%, cassia twig 4%, Lythrum salicaria 4%, green tea 4%, Radix Glycyrrhizae 4%, described percentage is weight percentage.
4, the production method of malicious additive falls in any one described cigarette among a kind of claim 1-3, and it comprises the following steps:
A) select the shiny-leaved yellowhorn of fresh maturation for use, clean, squeeze the juice, filter according to formula rate, the bright juice of getting clarification is standby;
B) with honeysuckle, perilla leaf, Lythrum salicaria, green tea according to prescription weighing, cleaning, pulverizing, with 100 ℃ of water loggings bubbles 24 hours, filtration was left standstill 12-24 hour, got supernatant, the concentrate that is concentrated to weight percent concentration and is 40-50% is standby;
C) bluish dogbane, cassia twig, Radix Glycyrrhizae were decocted 2 hours at 100 ℃ according to prescription weighing, cleaning, pulverizing, water, filter, filter residue was decocted 1 hour again, filter, merge twice filtrate and left standstill 12-24 hour, get supernatant, be concentrated to weight percent concentration and be 50%, standby;
D) merge above-mentioned three kinds of juices, mix, filter, sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011019638A CN1172610C (en) | 2001-01-19 | 2001-01-19 | Poison reducing additive for zhangguo cigarette and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011019638A CN1172610C (en) | 2001-01-19 | 2001-01-19 | Poison reducing additive for zhangguo cigarette and its preparing method |
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| CN1364432A CN1364432A (en) | 2002-08-21 |
| CN1172610C true CN1172610C (en) | 2004-10-27 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100551281C (en) * | 2008-01-23 | 2009-10-21 | 赵秋芝 | A kind of preparation method who removes the tobacco shred additive of cigarette poison and tool health-care treatment |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101485490B (en) * | 2008-12-16 | 2012-06-27 | 深圳烟草工业有限责任公司 | Preparation method of additive agent capable of causing flue-cured tobacco to have fragrance of oolong tea, flavoring as well as application in flue-cured tobacco |
| CN102507862B (en) * | 2011-10-16 | 2014-06-18 | 云南烟草科学研究院 | Method for judging degree of influence of cigarette additive concentration on special smoke index |
| CN103272196B (en) * | 2013-05-21 | 2015-06-24 | 李秋暑 | Toxin-eliminating drug composition, drug preparation and preparation methods of drug composition and drug preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100551281C (en) * | 2008-01-23 | 2009-10-21 | 赵秋芝 | A kind of preparation method who removes the tobacco shred additive of cigarette poison and tool health-care treatment |
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