CN117257693B - 具有即时美白保湿功效的余甘子啫喱面膜及其制备方法 - Google Patents
具有即时美白保湿功效的余甘子啫喱面膜及其制备方法 Download PDFInfo
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- CN117257693B CN117257693B CN202311551937.3A CN202311551937A CN117257693B CN 117257693 B CN117257693 B CN 117257693B CN 202311551937 A CN202311551937 A CN 202311551937A CN 117257693 B CN117257693 B CN 117257693B
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- phyllanthus emblica
- deionized water
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- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 29
- 230000002087 whitening effect Effects 0.000 title claims abstract description 23
- 235000015489 Emblica officinalis Nutrition 0.000 title claims abstract description 19
- 240000009120 Phyllanthus emblica Species 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 229940074122 phyllanthus emblica fruit extract Drugs 0.000 claims abstract description 26
- 239000000284 extract Substances 0.000 claims abstract description 22
- 239000008367 deionised water Substances 0.000 claims abstract description 18
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 18
- 241000736131 Sphingomonas Species 0.000 claims abstract description 17
- 238000000855 fermentation Methods 0.000 claims abstract description 16
- 230000004151 fermentation Effects 0.000 claims abstract description 16
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229940089468 hydroxyethylpiperazine ethane sulfonic acid Drugs 0.000 claims abstract description 14
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 13
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 13
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 12
- 239000003755 preservative agent Substances 0.000 claims abstract description 11
- 230000002335 preservative effect Effects 0.000 claims abstract description 11
- 239000002562 thickening agent Substances 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 238000003756 stirring Methods 0.000 claims description 14
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 11
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- 229920005862 polyol Polymers 0.000 claims description 9
- 150000003077 polyols Chemical class 0.000 claims description 9
- -1 dimethyl taurate Chemical compound 0.000 claims description 8
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 6
- 229940104261 taurate Drugs 0.000 claims description 6
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical group [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims description 5
- 229940001584 sodium metabisulfite Drugs 0.000 claims description 5
- 235000010262 sodium metabisulphite Nutrition 0.000 claims description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 3
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- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 3
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- BQMNFPBUAQPINY-UHFFFAOYSA-N azane;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound [NH4+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C BQMNFPBUAQPINY-UHFFFAOYSA-N 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
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- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 10
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- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 5
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 4
- 239000000419 plant extract Substances 0.000 description 3
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- 239000000523 sample Substances 0.000 description 3
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- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
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- 239000013522 chelant Substances 0.000 description 2
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- 239000001630 malic acid Substances 0.000 description 2
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- 239000011975 tartaric acid Substances 0.000 description 2
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- 239000011718 vitamin C Substances 0.000 description 2
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- 238000003556 assay Methods 0.000 description 1
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- 239000003153 chemical reaction reagent Substances 0.000 description 1
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Abstract
本发明涉及具有即时美白保湿功效的余甘子啫喱面膜及其制备方法，每100重量份的所述面膜，由以下组分的原料组成：余甘子果提取物0.2‑0.5份；羟乙基哌嗪乙烷磺酸0.2‑1.2份；鞘氨醇单胞菌发酵产物提取物0.2‑0.6份；增稠剂0.8‑1.5份；多元醇7‑20份；保湿活性物1‑4份；抗氧化剂0.04‑0.12份；防腐剂0.9‑1.6份；去离子水余量。本发明的面膜通过配方组分的搭配，制备出一款肤感温和无刺激的啫喱面膜，使得余甘子果提取物的稳定性得到了提高，也尽可能高地保存了配方中的活性组分含量，具有良好的即时美白保湿效果。
Description
技术领域
本发明涉及化妆品领域，特别是涉及一种具有即时美白保湿功效的余甘子啫喱面膜及其制备方法。
背景技术
余甘子（PHYLLANTHUS EMBLICA）果提取物是一款偏弱酸性的植物提取物，富含酚类、有机酸、糖类、维生素C、氨基酸等物质，由于富含多酚，具有较好的抗氧化能力，能螯合酪氨酸酶活性铜位点，抑制黑色素生成；含有大量没食子酸、酒石酸、柠檬酸、苹果酸等有机酸成分，能促使老化角质层脱落，加速角质细胞及少部分上层表皮细胞的更新速度，因此，可用于美白类化妆品的开发。目前余甘子果提取物已经应用在许多美白化妆品中，但其在即时美白功效上的配方仍比较少考察研究，应用前景还有很大的空间。
由于余甘子果提取物富含多酚类有机物，此类有机物具有较好的抗氧化能力，同时性质较为活泼，因此应用时如果体系搭配不当容易出现被氧化变色，如配方中过多游离的氢氧根离子会影响酚类化合物的稳定性，存在的某些金属离子也容易与酚类化合物络合，从而破坏酚类化合物的机构等；而且余甘子果提取物富含有机酸，电导率较一般植物提取物偏高，因此应用在配方时对配方中的增稠体系有一定的要求，如有一定的耐离子性和耐酸性等，而不同增稠体系的选择也会影响提取物在配方中的稳定性情况。因此，余甘子在即时美白产品中开发还具有一定难度。
发明内容
为了更好地使余甘子果提取物中活性成分的保留，在配方中稳定存在，本发明提供了设计了一款具有即时美白保湿功效的余甘子啫喱面膜，使配方中的活性成分能更好地被皮肤吸收。
具体地，本发明提供了一种具有即时美白保湿功效的余甘子啫喱面膜，每100重量份的面膜，由以下组分的原料组成：余甘子果提取物0.2-0.5份；羟乙基哌嗪乙烷磺酸0.2-1.2份；鞘氨醇单胞菌发酵产物提取物0.2-0.6份；增稠剂0.8-1.5份；多元醇7-20份；保湿活性物1-4份；抗氧化剂0.04-0.12份；防腐剂0.9-1.6份；去离子水余量。
优选地，每100重量份的所述面膜，由以下组分的原料组成：余甘子果提取物0.25-0.4份；羟乙基哌嗪乙烷磺酸0.4-1.0份；鞘氨醇单胞菌发酵产物提取物0.3-0.5份；增稠剂1-1.3份；多元醇7-20份；保湿活性物2-3.5份；抗氧化剂0.05-0.10份；防腐剂1-1.5份；去离子水余量。
余甘子（PHYLLANTHUS EMBLICA）果提取物是一款偏弱酸性的植物提取物，富含酚类、有机酸、糖类、维生素C、氨基酸等物质，由于富含多酚，具有较好的抗氧化能力，能螯合酪氨酸酶活性铜位点，抑制黑色素生成；含有大量没食子酸、酒石酸、柠檬酸、苹果酸等有机酸成分，能促使老化角质层脱落，加速角质细胞及少部分上层表皮细胞的更新速度。
羟乙基哌嗪乙烷磺酸是一种生物缓冲剂，具有温和软化角质，帮助活性成分渗透，光滑、柔软肌肤，提亮肤色，调节稳定产品PH值，稳定活性物的作用。
鞘氨醇单胞菌（SPHINGOMONAS）发酵产物提取物是一种多糖，具有独特的双螺旋结构，耐离子，增稠和保湿功能优异。
余甘子果提取物在不同配方中的活性物含量保留存在差异，进而使得产品在使用时呈现出水平不一的功效，为了保存提取物活性，提高配方中的产品稳定性，配方的体系搭配需要严格考量。本发明的啫喱面膜，添加余甘子果提取物、羟乙基哌嗪乙烷磺酸、鞘氨醇单胞菌发酵产物提取物等成分，通过配方组分的搭配，制备出一款肤感温和无刺激的啫喱面膜，使得余甘子果提取物的稳定性得到了提高，也尽可能高地保存了配方中的活性组分含量，进而使得对应啫喱面膜的产品使用在人皮肤上时体现出了更好的美白保湿的效果。
优选地，所述增稠剂为聚丙烯酰基二甲基牛磺酸钠、聚丙烯酰基二甲基牛磺酸铵、丙烯酰二甲基牛磺酸铵/VP共聚物中的一种或几种。
优选地，所述多元醇为甘油、丁二醇、聚乙二醇-8中的一种或几种。
优选地，所述保湿活性物为甜菜碱、海藻糖中的至少一种。
优选地，所述抗氧化剂为焦亚硫酸钠。
优选地，所述防腐剂包括对羟基苯乙酮和1,2-己二醇。
优选地，所述对羟基苯乙酮和1,2-己二醇的重量比为4-6：5-10。
本发明还提供了上述的具有即时美白保湿功效的余甘子啫喱面膜的制备方法，包括如下步骤：
1）称取配方量的各组分；
2）取2份多元醇预分散鞘氨醇单胞菌发酵产物提取物；预留3.5份去离子水；然后将增稠剂、剩余的去离子水和预分散后的多元醇及鞘氨醇单胞菌发酵产物提取物的混合物依次加入水相锅中，加热到80-85℃、均质、搅拌、保温；
3）搅拌降温，待步骤2）中的料体温度为55-60℃，将剩余的多元醇和防腐剂水浴溶解，溶解后加入到水相锅，随后加入保湿活性物，搅拌溶解均匀，降温；
4）待步骤3）中的物料温度降至45℃，将羟乙基哌嗪乙烷磺酸用3份预留的去离子水溶解均匀，将焦亚硫酸钠用0.5份的预留去离子水溶解均匀，加入水相锅中，最后将余甘子果提取物加入，搅拌均匀，降温。
优选地，所述步骤2）中，均质2-5分钟，80-100转/分钟搅拌保温20-30分钟，所述步骤3）和4）中，50-60转/分钟搅拌均匀，确保原料溶解或分散均匀，以免影响后期配方料体状态。
与现有技术相比，本发明具有以下有益效果：本发明的余甘子啫喱面膜，添加余甘子果提取物、羟乙基哌嗪乙烷磺酸、鞘氨醇单胞菌发酵产物提取物等成分，通过配方组分的优化，使得余甘子果提取物的稳定性得到了提高，也尽可能高地保存了配方中的活性组分含量，进而使得对应啫喱面膜的产品使用在人皮肤上时体现出了良好的即时美白、保湿的效果。
具体实施方式
为了便于理解本发明，下面将参照相关实施例对本发明进行更全面的描述。实施例中给出了本发明的较佳实施例。但是，本发明可以以许多不同的形式来实现，并不限于本文所描述的实施例。相反地，提供这些实施例的目的是使对本发明的公开内容的理解更加透彻全面。
除非另有定义，本文所使用的所有的技术和科学术语与属于本发明的技术领域的技术人员通常理解的含义相同。本文中在本发明的说明书中所使用的术语只是为了描述具体的实施例的目的，不是旨在于限制本发明。本文所使用的术语“和／或”包括一个或多个相关的所列项目的任意的和所有的组合。
以下实施例和对比例所用试剂均为市售可得；以下实施例和对比例中所用方法，如无特别说明，均为常规方法可实现。以下实施例和对比例中所述的份数如无特别说明，均为重量份数。
实施例
实施例1-8配方如表1所示。
各实施例制备方法，包括如下步骤：
1）准确称量配方成分中的各组分物料，同时将生产设备清洁干净；
2）取鞘氨醇单胞菌发酵产物提取物与2份多元醇预先分散，预留3.5份去离子水，然后将聚丙烯酰基二甲基牛磺酸铵、剩余的去离子水和预分散的鞘氨醇单胞菌发酵产物提取物和多元醇依次加入水相锅中，加热至80℃-85℃，高速均质2-5分钟，80-100转/分钟搅拌保温20-30分钟；
3）搅拌降温，待步骤2）中的料体温度降至55-60℃，将剩余的多元醇与对羟基苯乙酮、1,2-己二醇水浴溶解，溶解后加入到水相锅，加入甜菜碱和/或海藻糖，50-60转/分钟搅拌均匀，继续降温；
4）温度降至45℃，将羟乙基哌嗪乙烷磺酸用3份去离子水溶解均匀，焦亚硫酸钠用0.5份去离子水溶解均匀，加入搅拌锅中，最后将余甘子果提取物加入搅拌锅中，50-60转/分钟搅拌均匀，继续降温至室温；
5）取样检测，合格后，出料。
对比例
对比例1-7配方如表1所示。制备方法参考实施例。
表1 各实施例和对比例配方表
实验例
实验例1
对各实施例和对比例得到的样品进行三个月观测，稳定性数据如表2所示。
表2 配方稳定性测试数据
结果分析：各实施例样品均表现稳定，对比例中除了对比例4、5、7，其余均表现不稳定。对比例1-3的结果说明了羟乙基哌嗪乙烷磺酸、鞘氨醇单胞菌发酵产物提取物、聚丙烯酰基二甲基牛磺酸铵互相协同对配方体系的稳定作用。对比例6则反映了抗氧化剂的作用。
实验例2 总酚活性
采用Folin－Ciocalteu比色法，测量配方中总酚活性物的含量，考察时长为三个月的总酚含量变化，结果如表3所示。
表3 总酚含量变化
结果分析：初始总酚含量与余甘子果提取物的含量正相关，配方体系中余甘子果提取物含量越多，则初始总酚含量越高，但三个月后总酚含量与体系配方相关，对比例整体损失百分比高于各实施例，尤其是对比例1，对比例4，及对比例6、7。
该结果一方面说明了本发明实施例配方体系中余甘子果提取物活性成分保存较好，3个月总酚损失百分比均小于5%。同时也反应了配方中的活性组分的保存除了和羟乙基哌嗪乙烷磺酸、多元醇及抗氧剂影响显著外，其他组分也有相关，实施例中总酚损失较小，是配方中各组分互相协同的结果。另外与实验例1的结果相验证，侧面反映了本发明配方体系的稳定性。
实验例3 酪氨酸酶抑制率
根据上海日用化学品行业协会 团体标准T/SHRH 015-2018 化妆品-酪氨酸酶活性抑制实验方法测试各实施例样品的酪氨酸酶抑制率，结果如表4所示。
表4 酪氨酸酶抑制率
结果分析：酪氨酸酶是黑色素产生的限速酶，通常通过测定酪氨酸酶抑制率来反映化妆品的美白性能。上述各实施例的测试结果表明本发明实施例的余甘子啫喱面膜对酪氨酸酶抑制效果显著，具有良好的美白效果，对比例7的酪氨酸酶抑制率较低，表明本发明中余甘子果提取物对配方的美白功效的贡献作用十分显著。
实验例4 安全性测试
测试方法参照《2015化妆品安全技术规范》中的人体皮肤斑贴试验，首先对8个实施例配方做30人斑贴测试，测试结果全阴性，表明本发明护肤品温和无刺激。
实验例5 保湿度测试（参考QB/T 4256）
对实施例和空白组（去离子水）进行保湿功效测试：选取10名年龄在20-45岁的健康、无过敏性疾病的志愿者，室温（22±1）℃、湿度40%-60%的环境下进行实验。实验前，志愿者需在该环境下至少安静30min，待环境达到平衡后于左右前臂上画出3cm×3cm区域，区域间隔至少1cm。取样品按（2.0±0.1）mg/cm2的剂量涂抹于测试部位。受试者在使用化妆品5min、30min、4h后由技术人员使用皮肤水分测试探头测试实验部位水分含量。取5次测量平均值作为测试值，测试结果如表5所示，水分值变化率越高，说明保湿效果越好。
水分值变化率计算公式如下：
水分值变化率=（使用后水分含量-使用前水分含量）/使用前水分含量*100%
表5 保湿度测试结果
结果分析：实施例1-8制备的余甘子果提取物啫喱面膜具有良好的保湿能力，对比实施例1-9，实施例2的30min和4h水分值变化率最高，由此说明实施例2保湿效果最好。对比例2、4、5的余甘子啫喱面膜在30min有一定的保湿能力，但4h之后只能体现出微弱的保湿效果。
实验例6 即时美白效果测试
参考化妆品祛斑美白功效（第二法）测试方法，选择90名20-45岁健康志愿者随机分三组分别试用3个实施例产品，涂抹一定厚度于面部，十五分钟后洗去，分别在使用前及使用后10min、30min、2h三个时间点，使用皮肤色度仪和皮肤黑素检测仪测试受试者面部颜色参数，获得志愿者的ITA°和MI值，由经过培训的皮肤科医生借助由浅至深肤色的色卡对试验部位色斑区进行肤色评估，并记录评分。结果如表6-8所示。
结果表明：三个实施例配方均在受试者使用10min后开始，受试者面部的ITA°值、MI值和视觉评估评分对比使用前出现统计学差异，表明三个应用例配方均有即时提高皮肤亮度，并使皮肤颜色变浅的功效。
表6 志愿者使用产品前后ITA°值及差异分析
表7 志愿者使用产品前后MI值及差异分析
表8 志愿者使用产品前后视觉评估评分及差异分析
综上可以看出，本发明基于余甘子果提取物的美白功效，通过优化配方，添加羟乙基哌嗪乙烷磺酸、鞘氨醇单胞菌发酵产物提取物、增稠剂、保湿活性物、多元醇和抗氧化剂等成分，通过配方组分的搭配，得到了体系稳定的啫喱面膜，而且使得余甘子果提取物的稳定性得到了提高，尽可能高地保存了配方中的活性组分含量，3个月总酚损失百分比均小于5%；得到的啫喱面膜的产品使用在人皮肤上时体现出了更好的美白保湿的效果，即时美白效果显著，而且温和无刺激。
以上对本发明实施例所提供的技术方案进行了详细介绍，本文中应用了具体个例对本发明实施例的原理以及实施方式进行了阐述，以上实施例的说明只适用于帮助理解本发明实施例的原理；同时，对于本领域的一般技术人员，依据本发明实施例，在具体实施方式以及应用范围上均会有改变之处，综上所述，本说明书内容不应理解为对本发明的限制。
Claims (5)
1.一种具有即时美白保湿功效的余甘子啫喱面膜，其特征在于，每100重量份的所述面膜，由以下组分的原料组成：余甘子果提取物0.2-0.5份；羟乙基哌嗪乙烷磺酸0.2-1.2份；鞘氨醇单胞菌发酵产物提取物0.2-0.6份；增稠剂0.8-1.5份；多元醇7-20份；保湿活性物1-4份；抗氧化剂0.04-0.12份；防腐剂0.9-1.6份；去离子水余量；
所述增稠剂为聚丙烯酰基二甲基牛磺酸钠、聚丙烯酰基二甲基牛磺酸铵、丙烯酰二甲基牛磺酸铵/VP共聚物中的一种或几种；
所述多元醇为甘油、丁二醇中的一种或几种；
所述保湿活性物为甜菜碱、海藻糖中的至少一种；
所述抗氧化剂为焦亚硫酸钠；
所述防腐剂包括对羟基苯乙酮和1,2-己二醇。
2.根据权利要求1所述的面膜，其特征在于，每100重量份的所述面膜，由以下组分的原料组成：余甘子果提取物0.25-0.4份；羟乙基哌嗪乙烷磺酸0.4-1.0份；鞘氨醇单胞菌发酵产物提取物0.3-0.5份；增稠剂1-1.3份；多元醇7-20份；保湿活性物2-3.5份；抗氧化剂0.05-0.10份；防腐剂1-1.5份；去离子水余量。
3.根据权利要求1所述的面膜，其特征在于，所述对羟基苯乙酮和1,2-己二醇的重量比为4-6：5-10。
4.一种如权利要求1或2所述的面膜的制备方法，其特征在于，包括如下步骤：
1）称取配方量的各组分；
2）取2份多元醇预分散鞘氨醇单胞菌发酵产物提取物；预留3.5份去离子水；然后将增稠剂、剩余的去离子水、预分散后的多元醇及鞘氨醇单胞菌发酵产物提取物的混合物依次加入水相锅中，加热到80-85℃、均质、搅拌、保温；
3）搅拌降温，待步骤2）中的料体温度为55-60℃，将剩余的多元醇和防腐剂水浴溶解，溶解后加入到水相锅，随后加入保湿活性物，搅拌溶解均匀，降温；
4）待步骤3）中的物料温度降至45℃，将羟乙基哌嗪乙烷磺酸用3份预留的去离子水溶解均匀，将焦亚硫酸钠用0.5份的预留去离子水溶解均匀，加入水相锅中，最后将余甘子果提取物加入，搅拌均匀，降温。
5.根据权利要求4所述的制备方法，其特征在于，所述步骤2）中，均质2-5分钟，80-100转/分钟搅拌，保温20-30分钟，所述步骤3）和4）中，50-60转/分钟搅拌均匀。
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| CN116763702A (zh) * | 2022-03-10 | 2023-09-19 | 泉后(广州)生物科技研究院有限公司 | 一种淡化深层斑点的组合物及其制备方法与应用 |
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