CN117257684A - Oil control composition and preparation method and application thereof - Google Patents
Oil control composition and preparation method and application thereof Download PDFInfo
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- CN117257684A CN117257684A CN202311305782.5A CN202311305782A CN117257684A CN 117257684 A CN117257684 A CN 117257684A CN 202311305782 A CN202311305782 A CN 202311305782A CN 117257684 A CN117257684 A CN 117257684A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to the technical field of cosmetics, and particularly discloses an oil control composition, and a preparation method and application thereof. The oil control composition comprises, by weight, 2% -5% of a verbena leaf extract, 3% -7% of a spiraea ulmaria extract, 1% -3% of a medicinal layer porus extract, 0.1% -0.3% of adenosine, 0.2% -0.5% of a preservative, 0.5% -1% of a humectant and the balance of a solvent. A preparation method of an oil control composition comprises sterilizing solvent, sequentially adding adenosine, antiseptic, herba Verbenae leaf extract, flos Spiraeae Fortunei extract, medicinal Phellinus extract and humectant, and stirring to obtain the oil control composition. An application of the oil control composition is to add the oil control composition into cosmetics. The oil control composition has remarkable effects of inhibiting skin oil production, repairing skin barrier and maintaining the water-oil balance state of oily sensitive skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an oil control composition, a preparation method and application thereof.
Background
Oily sensitive skin refers to sensitive skin with excessive secretion of skin grease, easy blockage of pores, impaired skin barrier, insufficient skin moisture retention, and susceptibility to repeated inflammation caused by external stimulus. The sensitive skin typically shows four points: the first is that the skin is vigorous in oil production but still feels dry and water deficient, the second is that the skin is easy to be reddened by external stimulus, the third is that pores are large, skin color is dark, and the fourth is that the skin is easy to grow acne, closed mouth and acnes.
Most of the existing cosmetics are respectively suitable for oily skin, dry skin, neutral skin and sensitive skin, and the oily sensitive skin can be usually selected from the applicable cosmetics of the oily skin and the sensitive skin for daily care. While the conventional oily skin cosmetics can have an effect of inhibiting the secretion of oil, most oily skin cosmetics are usually added with a component having a stimulating effect on the skin in order to achieve a more excellent oil control effect, so as to achieve the purposes of inhibiting sebaceous glands and shrinking pores, so that the oily sensitive skin is easily stimulated by the component having the stimulating effect, the inflammatory reaction of the oily sensitive skin is aggravated, and the state of the oily sensitive skin is further worsened. The existing cosmetics for sensitive skin are mild in components, but poor in oil control effect, and are more suitable for dry sensitive skin, after the cosmetics are used for oily sensitive skin, skin grease secretion is difficult to effectively control, skin grease is still exuberant, and the cosmetics for sensitive skin generally have good nourishing effect, are thicker in face, further exacerbate pore burden of oily sensitive skin, and are easier to cause acne.
In view of the above-mentioned related art, the inventors have considered that it is necessary to develop a cosmetic suitable for oily sensitive skin, that is, a mild cosmetic which can control oil and can relax skin.
Disclosure of Invention
In order to ensure that the cosmetic has good oil control effect and can ease the skin, the application provides an oil control composition, and a preparation method and application thereof. The oil control composition has the remarkable effects of inhibiting oil production of skin and repairing skin barriers. With the continuous use of the oil control composition, oily sensitive skin can maintain a stable water-oil balance state for a long time.
In a first aspect, the present application provides an oil control composition according to the following technical solution:
an oil control composition comprising, in percent of the oil control composition:
herba Verbenae leaf extract: 2% -5%;
spiraea ulmaria extract: 3% -7%;
a pharmaceutical lamellar porus extract: 1% -3%;
adenosine: 0.1 to 0.3 percent;
preservative: 0.2 to 0.5 percent;
humectant: 0.5 to 1 percent;
the balance being solvent.
In the technical scheme, the vervain (Verbena officinalis) leaf extract is extracted from branches and leaves of vervain. The vervain is produced in Hubei, guizhou and other places, is a cosmetic ingredient with Chinese characteristics, has various effects of relieving skin, moisturizing, resisting oxidation and the like, and is suitable for most skin types.
Spiraea ulmaria (Spiraea ulmaria) is an aliased herb of the genus Filipendula of the family Rosaceae, a perennial herb, and is often used as a herbal medicine. The spiraea ulmaria extract contains rich flavonoid compounds and tannins, which endows the spiraea ulmaria with good anti-inflammatory and astringent effects.
The medicinal Phellinus extract is extracted from traditional Chinese medicine, such as Armillariella Mellea (Fomes officinalis) fruiting body of Fomitopsis plant of Polyporaceae, and mainly is mainly taken on trunk of Pinus koraiensis and Larix Gmelini. The medicinal layer porus extract has good effects of inhibiting oil secretion, astringing pores and smoothing and tightening skin.
Adenosine is a derivative of adenine and ribose, is a small molecular active substance, and is found to have good moisturizing, antibacterial, anti-inflammatory and anti-wrinkle effects on skin.
According to the oil control composition, the verbena leaf extract, the spiraea ulmaria extract, the medicinal layer porus extract and the adenosine are added at the same time, and the remarkable effects of regulating the water-oil balance of the oil-sensitive skin, repairing the skin barrier of the oil-sensitive skin and enhancing the tolerance of the oil-sensitive skin, especially the tolerance to ultraviolet rays, are achieved through the synergistic effect among the verbena leaf extract, the spiraea ulmaria extract, the medicinal layer porus extract and the adenosine.
The spiraea ulmaria extract and the medicinal layer porus extract are compounded, so that the effects of inhibiting the secretion of grease of oily sensitive skin and reducing the secretion of grease of oily sensitive skin are achieved, meanwhile, the effects of remarkably supplementing the moisture in the skin and relieving the skin are achieved through the compounding of the verbena leaf extract and the adenosine, and finally, the purposes of mildly controlling the oil, converging and relieving the skin and realizing the water-oil balance of the oily sensitive skin are achieved.
The preparation method achieves the obvious effect of inhibiting propionibacterium acnes through the combination of the verbena leaf extract and the spiraea ulmaria extract, achieves the obvious effect of inhibiting skin inflammation through the combination of the verbena leaf extract, the spiraea ulmaria extract and the adenosine, and finally achieves the purposes of repairing the skin barrier of oily sensitive skin, maintaining the stability of the oily sensitive skin and eliminating the erythema of the oily sensitive skin through the obvious antibacterial effect and the effect of inhibiting inflammation.
The aim of remarkably enhancing the tolerance of oily sensitive skin to ultraviolet stimulation is achieved through compounding of the verbena leaf extract, the spiraea ulmaria extract and the medicinal layer porus extract. The oily sensitive skin is easy to block hair follicles and the skin is also very easy to be stimulated by ultraviolet rays to generate inflammatory reaction, and the application finds that the combination of the verbena leaf extract, the spiraea ulmaria extract and the medicinal layer porus extract has good technical effect of absorbing ultraviolet rays, and the oily sensitive skin is smeared on the skin, so that good sun-proof effect can be achieved, further stimulation of ultraviolet rays to the oily sensitive skin is weakened, and meanwhile, the risk of further blocking pores due to smearing sun-proof cream is avoided.
Preferably, the oil control composition comprises the following components in percentage:
herba Verbenae leaf extract: 2% -4%;
spiraea ulmaria extract: 3% -5%;
a pharmaceutical lamellar porus extract: 2% -3%;
adenosine: 0.2 to 0.3 percent;
preservative: 0.2 to 0.5 percent;
humectant: 0.5 to 1 percent;
the balance being solvent.
According to the technical scheme, the dosage ranges of the verbena leaf extract, the spiraea ulmaria extract, the medicinal layer porus extract and the adenosine are further limited, so that the verbena leaf extract, the spiraea ulmaria extract, the medicinal layer porus extract and the adenosine have better synergistic effect, and the effects of better regulating the water-oil balance of the oil-sensitive skin, repairing the skin barrier of the oil-sensitive skin and enhancing the tolerance of the oil-sensitive skin, especially the tolerance to ultraviolet rays, are exerted.
Preferably, the mass ratio of the verbena leaf extract, the spiraea ulmaria extract, the medicinal layer porus extract and the adenosine is 3:3:3:0.2.
in the technical scheme, the mass ratio of the verbena leaf extract, the spiraea ulmaria extract, the medicinal layer porus extract and the adenosine is 3:3:3:0.2, the dosage ratio of the vervain leaf extract, the spiraea ulmaria extract, the medicinal layer porus extract and the adenosine is adjusted to be optimal, and the vervain leaf extract, the spiraea ulmaria extract, the medicinal layer porus extract and the adenosine are compounded in a synergistic way, so that the interaction plays the optimal roles of adjusting the water-oil balance of the oil-sensitive skin, repairing the skin barrier of the oil-sensitive skin and enhancing the tolerance of the oil-sensitive skin, especially the tolerance to ultraviolet rays.
Preferably, the preservative is p-hydroxyacetophenone.
According to the technical scheme, the p-hydroxyacetophenone is used as a preservative, so that the stability of the oil control composition is further improved, and the oil control composition is ensured to exert the effects of well inhibiting oil production of oily sensitive skin, repairing the skin barrier of the oily sensitive skin and improving the water-oil balance problem of the oily sensitive skin.
Preferably, the humectant is 1, 2-hexanediol.
According to the technical scheme, 1, 2-hexanediol is selected as a humectant, so that the effects of supplementing moisture in skin and relieving skin can be achieved by further matching with the verbena leaf extract and adenosine, and the effect of maintaining the stability of the oil control composition can be achieved by further cooperating with the hydroxyacetophenone.
In a second aspect, the present application provides a method for preparing an oil control composition, which adopts the following technical scheme:
a method of preparing an oil control composition comprising the steps of:
step 1: heating the solvent to 85-88 ℃, and preserving heat for 20-30 min to ensure complete sterilization;
step 2: after adding adenosine and preservative, stirring uniformly;
step 3: cooling to 40-45 ℃, adding the verbena leaf extract, the spiraea ulmaria extract, the medicinal layer porus extract and the humectant, and stirring and mixing uniformly to prepare the oil control composition.
In the above technical scheme, the solvent is sterilized first. And then adenosine, preservative and other components are sequentially added, so that the components are mixed more uniformly, and especially the adenosine can be stably and uniformly dispersed in the oil control composition, and the components in the oil control composition can exert the effects of inhibiting oil production, repairing skin barrier and improving the water-oil balance problem of oily sensitive skin.
In a third aspect, the application of the oil control composition provided by the application adopts the following technical scheme:
an application of the oil control composition comprises adding the oil control composition into cosmetics.
Preferably, the cosmetic product includes, but is not limited to, an emulsion, a cream, a essence, a mask, a foundation, and a powder.
According to the technical scheme, the oil control composition is added into cosmetics such as emulsion, face cream, essence, facial mask, foundation solution and powder cream, so that good effects of inhibiting oil production, repairing skin barrier and improving water-oil balance of oil sensitive skin are achieved, and the cosmetics added with the oil control composition have better suitability with the oil sensitive skin.
In summary, the present application includes at least one of the following beneficial technical effects:
1. according to the oil control composition, the verbena leaf extract, the spiraea ulmaria extract, the medicinal layer porus extract and the adenosine are added at the same time, and the remarkable effects of regulating the water-oil balance of the oil-sensitive skin, repairing the skin barrier of the oil-sensitive skin and enhancing the tolerance of the oil-sensitive skin, especially the tolerance to ultraviolet rays, are achieved through the synergistic effect among the verbena leaf extract, the spiraea ulmaria extract, the medicinal layer porus extract and the adenosine.
2. The spiraea ulmaria extract and the medicinal layer porus extract are compounded, so that the effects of inhibiting the secretion of grease of oily sensitive skin and reducing the secretion of grease of oily sensitive skin are achieved, meanwhile, the effects of remarkably supplementing the moisture in the skin and relieving the skin are achieved through the compounding of the verbena leaf extract and the adenosine, and finally, the purposes of mildly controlling the oil, converging and relieving the skin and realizing the water-oil balance of the oily sensitive skin are achieved.
3. The preparation method achieves the obvious effect of inhibiting propionibacterium acnes through the combination of the verbena leaf extract and the spiraea ulmaria extract, achieves the obvious effect of inhibiting skin inflammation through the combination of the verbena leaf extract, the spiraea ulmaria extract and the adenosine, and finally achieves the purposes of repairing the skin barrier of oily sensitive skin, maintaining the stability of the oily sensitive skin and eliminating the erythema of the oily sensitive skin through the obvious antibacterial effect and the effect of inhibiting inflammation.
4. The aim of remarkably enhancing the tolerance of oily sensitive skin to ultraviolet stimulation is achieved through compounding of the verbena leaf extract, the spiraea ulmaria extract and the medicinal layer porus extract. The oily sensitive skin is easy to block hair follicles and the skin is also very easy to be stimulated by ultraviolet rays to generate inflammatory reaction, and the application finds that the combination of the verbena leaf extract, the spiraea ulmaria extract and the medicinal layer porus extract has good technical effect of absorbing ultraviolet rays, and the oily sensitive skin is smeared on the skin, so that good sun-proof effect can be achieved, further stimulation of ultraviolet rays to the oily sensitive skin is weakened, and meanwhile, the risk of further blocking pores due to smearing sun-proof cream is avoided.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples.
Example 1
An oil control composition comprising 82.3kg of water, 2kg of a verbena leaf extract, 7kg of a spiraea ulmaria extract, 3kg of a medicinal layer porus extract, 0.1kg of adenosine, 0.2kg of p-hydroxyacetophenone, 0.5kg of 1, 2-hexanediol.
Wherein, the extract of the verbena leaf is purchased in NCKemical biotechnology S.L, and the extraction ratio is 10:1.
wherein, the spiraea ulmaria extract is purchased in NCKemical biotechnology S.L, and the extraction ratio is 10:1.
wherein, the medicinal layer porus extract is purchased from Basiff (China) Limited company, and the extraction ratio is 10:1.
among them, adenosine is purchased from Guilin Walmean Chusmei Biotechnology Co.
The preparation method of the oil control composition comprises the following steps:
step 1: the solvent was warmed to 85℃and then incubated for 30min.
Step 2: after adding adenosine and preservative, stirring uniformly.
Step 3: cooling to 40deg.C, adding herba Verbenae leaf extract, flos Spiraeae Fortunei extract, medicinal Phellinus extract and humectant, and stirring to obtain oil control composition.
Example 2
An oil control composition, unlike example 1, comprises 81.5kg of water, 5kg of a verbena leaf extract, 3kg of a spiraea ulmaria extract, 1kg of a medicinal layer porus extract, 0.3kg of adenosine, 0.5kg of p-hydroxyacetophenone, 1kg of 1, 2-hexanediol.
The preparation method of the oil control composition comprises the following steps:
step 1: the solvent was warmed to 88℃and then incubated for 20min.
Step 2: after adding adenosine and preservative, stirring uniformly.
Step 3: cooling to 45deg.C, adding herba Verbenae leaf extract, flos Spiraeae Fortunei extract, medicinal Phellinus extract and humectant, and stirring to obtain oil control composition.
Example 3
An oil control composition, unlike example 1, comprises 84kg of water, 2kg of a verbena leaf extract, 5kg of a spiraea ulmaria extract, 2kg of a medicinal layer porus extract, 0.2kg of adenosine, 0.3kg of p-hydroxyacetophenone, 0.7kg of 1, 2-hexanediol.
Example 4
An oil control composition, unlike example 1, comprises 85kg water, 3kg Verbena leaf extract, 3kg spiraea ulmaria extract, 3kg medicinal layer porus extract, 0.2kg adenosine, 0.5kg p-hydroxyacetophenone, 0.5kg1, 2-hexanediol.
Comparative example 1
An oil control composition, unlike example 4, was replaced with aloe vera extract in equal amounts.
Wherein the aloe extract is water extract, and the extraction ratio is 10:1.
comparative example 2
An oil control composition, unlike example 4, was replaced by centella asiatica extract in equal amounts.
Wherein the centella asiatica extract is water extract, the extraction ratio is 10:1.
comparative example 3
An oil control composition, unlike example 4, the medicinal layer porus extract was replaced with the paeonia lactiflora extract in equal amount.
Wherein the paeonia lactiflora extract is an aqueous extract, and the extraction ratio is 10:1.
comparative example 4
An oil control composition, unlike example 4, has an equivalent amount of adenosine replaced with a ceramide.
Experimental example 1
And verifying the irritation of the oil control composition.
Human body patch test was performed with reference to cosmetic safety technical Specification (2015 edition), and the irritation of the oil control composition to human body was measured.
240 volunteers are selected, 8 groups are evenly divided, 30 persons in each group are subjected to a skin closed type patch test, 0.02ml of the oil control composition is dripped into the patch, the patch is sealed above the inner side of the left arm of a subject by using an adhesive tape, the patch is removed after 24 hours, the skin irritation is observed at 30 minutes, 24 hours and 48 hours after the removal, and the irritation results are recorded, wherein the results are shown in Table 1.
Table 1:
in combination with examples 1 to 4, comparative examples 1 to 4 and Table 1, it is apparent that the difference between example 4 and comparative example 1 is that comparative example 1 uses aloe extract to replace herba Verbenae leaf extract equally, the difference between example 4 and comparative example 4 is that comparative example 4 uses ceramide to replace adenosine equally, and the mildness of example 4 to skin is better, thus it is seen that only the compounding of herba Verbenae leaf extract and adenosine can achieve the effects of promptly supplementing moisture in skin and relieving skin, and perfectly balance the dry and uncomfortable feeling of skin caused by inhibiting grease secretion and astringing pores due to the spiraea ulmaria extract and the medicinal layer porus extract.
Experimental example 2
And verifying the antibacterial effect of the oil control composition.
The bacteriostasis of the oil control composition of each example and comparative example was tested by oxford cup bacteriostasis test.
Experimental samples: the oil control composition and sterile water were mixed at 5:95 mass ratio and obtaining the experimental sample.
Experimental strain: propionibacterium acnes (ATCC 11827).
The experimental method comprises the following steps: preparing a strain suspension: sterilizing the nutrient broth, adding activated Propionibacterium acnes, and preparing into a nutrient broth with Propionibacterium acnes content of about 10 6 cfu/ml of experimental bacterial liquid.
Preparation of a culture dish: after the agar medium is sterilized, the plates are poured, 20ml of agar medium is poured into each plate, and the plates are obtained after solidification.
Inoculating: sucking 1m of experimental bacteria, dripping the liquid into the surface of a culture dish, uniformly coating by using a coater, uniformly dividing each dish into four areas, vertically and uniformly placing an oxford cup in each area, and lightly pressing to ensure that the oxford cup is in contact with a culture medium without gaps.
Loading: 200 mu L of experimental sample is respectively dripped into each oxford cup, wherein one culture dish is not dripped with the experimental sample and is used as a blank control group; after 16h of stationary culture at 37 ℃, the diameters of the inhibition zones are measured, the experimental results are averaged, the inhibition zone diameter <10mm indicates no inhibition, the inhibition zone diameter >10mm and the inhibition zone diameter <15mm are moderate inhibition, the inhibition zone diameter >15mm is high inhibition, and the experimental results are averaged, see table 2.
Table 2:
| group of | Diameter of inhibition zone (mm) |
| Example 1 | 16.75 |
| Example 2 | 16.75 |
| Example 3 | 17.00 |
| Example 4 | 17.25 |
| Comparative example 1 | 10.75 |
| Comparative example 2 | 10.25 |
| Comparative example 3 | 15.75 |
| Comparative example 4 | 16.25 |
In combination with examples 1 to 4, comparative examples 1 to 4 and Table 2, it is apparent that the difference between example 4 and comparative example 1 is that comparative example 1 uses aloe extract to replace herba Verbenae leaf extract in equal amount, the difference between example 4 and comparative example 2 is that comparative example 2 uses centella asiatica extract to replace spiraea ulmaria extract in equal amount, and the inhibition effect of example 4 on Propionibacterium acnes is better, so that the compounding of herba Verbenae leaf extract and spiraea ulmaria extract can achieve remarkable effect of inhibiting Propionibacterium acnes, effectively inhibit further development of inflammation of oil-sensitive skin and promote restoration of oil-sensitive skin.
Experimental example 3
And verifying the sun-proof effect of the oil control composition.
The sunscreen power of the oil control compositions of the above examples and comparative examples was tested using the sun protection factor meter SPF-290S from Optometrics, inc. of the United states.
The experimental method comprises the following steps: the oil control compositions of each example and comparative example were uniformly applied to a Transpore skin-imitating tape of 70.7mm.times.70.7 mm in area, ensuring an application thickness of 2. Mu.L/cm 2 . After the oil control composition was completely dried, a scan measurement was performed with SPF-290S and the results are recorded in Table 3.
Table 3:
| group of | SPF value |
| Example 1 | 12.11 |
| Example 2 | 12.08 |
| Example 3 | 12.17 |
| Example 4 | 12.19 |
| Comparative example 1 | 2.03 |
| Comparative example 2 | 1.02 |
| Comparative example 3 | 1.86 |
| Comparative example 4 | 12.18 |
In combination with examples 1 to 4, comparative examples 1 to 4 and Table 3, it is apparent that the difference between example 4 and comparative example 1 is that the aloe extract is used for replacing the verbena leaf extract in equal amount, the difference between example 4 and comparative example 2 is that the centella asiatica extract is used for replacing the spiraea ulmaria extract in equal amount in comparative example 2, the difference between example 4 and comparative example 3 is that the paeonia lactiflora extract is used for replacing the medicinal layer porus extract in equal amount in comparative example 3, and the protective effect of example 4 on ultraviolet rays is better, so that the complex of the verbena leaf extract, the spiraea ulmaria extract and the medicinal layer porus extract has a good technical effect of absorbing ultraviolet rays, and the complex can achieve a good sun-screening effect when being smeared on skin, further stimulus of ultraviolet rays to oily sensitive skin is weakened, and meanwhile, the risk of further blocking pores when being smeared with sun cream is avoided.
Experimental example 4
And verifying the skin care effect of the oil control composition.
Experimental samples: the oil control composition and sterile water were mixed at 5:95 mass ratio and obtaining the experimental sample.
80 subjects between 18 and 35 years old are selected, oily sensitive skin is mainly represented by a large number of blackheads and whiteheads, and the basic value of the grease content of a testing area of the forehead of the face of each subject in an unclean state is more than 180, and the subjects are randomly distributed into 8 groups of 10 people. The test sample is uniformly smeared on the face for 1+/-0.5 mL each time after the face is cleaned by water in the morning and evening, the smearing time is 1-2 min each time, no other medicines or cosmetics which can influence the test result are used during the test, and the test sample is continuously used for 14 days.
And (3) detecting the content of grease: the test was performed before and after 14 days of use, a test area of the forehead of the face of the subject was selected, the experimenter measured the fat content using a germany CK multifunctional skin tester CK-MPA10 fat test probe Sebumeter SM815, each group was averaged, and the fat content change rate (%) was calculated, and the fat content change rate (%) = [ (fat content before use-fat content after 14 days of use)/fat content before use ] ×100% was recorded, and the experimental results were shown in table 4.
And (3) detecting the moisture content: the test was performed before and after 14 days, the frontal test area of the face of the subject was selected, the experimenter measured the moisture content using a germany CK multifunctional skin tester CK-MPA10 moisture test probe Corneometer CM825, each group averaged, and the moisture content change rate (%) was calculated, the moisture content change rate (%) = [ (moisture content before use-moisture content after 14 days) per use ]/moisture content before use ] ×100%, and the experimental results were recorded in table 4.
Percutaneous moisture loss (TEWL value): the test was performed once before and 14 days after the use, a test area of the forehead of the face of the subject was selected, the experimenter measured the amount of the percutaneous moisture loss using a germany CK multifunctional skin tester CK-MPA10 moisture loss test probe tewattmeter TM300, each group was averaged, and the rate of change (%) of the amount of the percutaneous moisture loss was calculated, and the rate of change (%) of the amount of the percutaneous moisture loss= [ (amount of the percutaneous moisture loss before use-amount of the percutaneous moisture loss after use for 14 days)/amount of the percutaneous moisture loss before use ] ×100%, and the experimental results were recorded in table 4.
The smaller the percutaneous moisture loss value, the better the skin barrier repair effect.
Satisfaction evaluation: subjects performed subjective evaluation scores of 0 to 5 points on the test samples after 14 days of use, 0 points representing very dissatisfaction, 5 points representing very satisfaction, average values for each group, and test results were recorded in table 4.
Table 4:
in combination with examples 1 to 4, comparative examples 1 to 4 and Table 4, it is apparent that example 4 differs from comparative example 1 in that the aloe vera extract is replaced by an equivalent amount of the verbena leaf extract, example 4 differs from comparative example 2 in that the centella asiatica extract is replaced by an equivalent amount of the spiraea ulmaria extract, example 4 differs from comparative example 3 in that the paeonia lactiflora extract is replaced by an equivalent amount of the medicinal layer porus extract, example 4 differs from comparative example 4 in that the ceramide is replaced by an equivalent amount of the adenosine, and that the oil-controlling moisturizing and skin barrier-repairing effects of example 4 are better. Therefore, the effects of remarkably regulating the water-oil balance of the oil-sensitive skin and repairing the skin barrier of the oil-sensitive skin can be achieved only by adding the verbena leaf extract, the spiraea ulmaria extract, the medicinal layer porus extract and the adenosine into the oil control composition at the same time through the synergistic effect among the verbena leaf extract, the spiraea ulmaria extract, the medicinal layer porus extract and the adenosine.
The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.
Claims (8)
1. An oil control composition, characterized by comprising the following components in percentage by weight:
herba Verbenae leaf extract: 2% -5%;
spiraea ulmaria extract: 3% -7%;
a pharmaceutical lamellar porus extract: 1% -3%;
adenosine: 0.1% -0.3%;
preservative: 0.2% -0.5%;
humectant: 0.5% -1%;
the balance being solvent.
2. An oil control composition according to claim 1, comprising the following components in percentage of the oil control composition:
herba Verbenae leaf extract: 2% -4%;
spiraea ulmaria extract: 3% -5%;
a pharmaceutical lamellar porus extract: 2% -3%;
adenosine: 0.2% -0.3%;
preservative: 0.2% -0.5%;
humectant: 0.5% -1%;
the balance being solvent.
3. The oil control composition according to claim 1, wherein the mass ratio of the verbena leaf extract, the spiraea ulmaria extract, the medicinal layer porus extract and the adenosine is 3:3:3:0.2.
4. an oil control composition according to claim 1, wherein the preservative is p-hydroxyacetophenone.
5. An oil control composition according to claim 4 wherein the humectant is 1, 2-hexanediol.
6. A method for preparing the oil control composition according to any one of claims 1 to 5, comprising the steps of:
step 1: heating the solvent to 85-88 ℃, and then preserving heat for 20-30 min to ensure complete sterilization;
step 2: after adding adenosine and preservative, stirring uniformly;
step 3: cooling to 40-45 ℃, adding the verbena leaf extract, the spiraea ulmaria extract, the medicinal layer porus extract and the humectant, and stirring and mixing uniformly to obtain the oil control composition.
7. Use of the oil control composition according to any one of claims 1 to 5, wherein the oil control composition is added to a cosmetic.
8. The use of an oil control composition according to claim 7, wherein the cosmetic product comprises, but is not limited to, an emulsion, a cream, a serum, a mask, a foundation, a vanishing cream.
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