CN117225358B - Chiral amine medicine intermediate catalytic reaction device - Google Patents
Chiral amine medicine intermediate catalytic reaction device Download PDFInfo
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- CN117225358B CN117225358B CN202311512837.XA CN202311512837A CN117225358B CN 117225358 B CN117225358 B CN 117225358B CN 202311512837 A CN202311512837 A CN 202311512837A CN 117225358 B CN117225358 B CN 117225358B
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- catalytic reaction
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- 239000003814 drug Substances 0.000 title claims abstract description 50
- 238000006555 catalytic reaction Methods 0.000 title claims abstract description 19
- 150000001412 amines Chemical class 0.000 title claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 56
- 230000005540 biological transmission Effects 0.000 claims abstract description 40
- 238000006243 chemical reaction Methods 0.000 claims abstract description 23
- 229940079593 drug Drugs 0.000 claims abstract description 12
- 238000003756 stirring Methods 0.000 claims abstract description 12
- 230000008878 coupling Effects 0.000 claims description 14
- 238000010168 coupling process Methods 0.000 claims description 14
- 238000005859 coupling reaction Methods 0.000 claims description 14
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 10
- 230000008569 process Effects 0.000 abstract description 8
- 239000006185 dispersion Substances 0.000 abstract description 6
- 239000000543 intermediate Substances 0.000 description 10
- 239000012530 fluid Substances 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
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Abstract
The invention discloses a chiral amine medicine intermediate catalytic reaction device, which relates to the technical field of medicine catalytic reaction devices and comprises a processing frame with a rectangular shape, wherein a reaction kettle is hung between upper and lower diagonal lines of the processing frame, the middle part of the bottom of the reaction kettle is rotationally connected with an outer rotary barrel, the bottom of the outer rotary barrel is fixedly provided with a bottom plate, the inner ring of the bottom plate is slidingly connected with a fixed plate, the fixed plate is rotationally connected with an inner rotary barrel, a driving device is connected between the outer rotary barrel and the inner rotary barrel in a transmission way, the chiral amine medicine intermediate catalytic reaction device is matched with two toothed rings through gears, so that the inner rotary barrel and the outer rotary barrel rotate at equal speed and in opposite directions, then in the process of rotating the outer rotary barrel, medicines on the surface of the outer rotary barrel are replaced into the inner rotary barrel through water outlet holes, are sequentially shunted outside the inner rotary barrel, preliminary dispersion is carried out inside the inner rotary barrel, and the medicine stirring and mixing efficiency is improved, and the catalytic reaction of an intermediate is facilitated.
Description
Technical Field
The invention relates to the technical field of medicine catalytic reaction device equipment, in particular to a chiral amine medicine intermediate catalytic reaction device.
Background
Chiral medicine refers to a pair of enantiomers which are real objects and mirror images after chiral centers are introduced into the molecular structure of the medicine. Each pair of chemically pure enantiomers differs in physicochemical properties (not only in optical rotation) and may be named R-or S-form, D-or L-form, left-or right-handed according to different nomenclature.
The existing chiral medicine or other medicines are synthesized into intermediates by adding a large amount of catalysts, affected and then catalyzed by the intermediates, and the intermediates are synthesized by a reaction vessel, and the existing synthesis usually adopts a reaction kettle, which is generally strictly regulated for a medicine reaction kettle, wherein the complete disinfection performance is required in production, and the air tightness of each pipeline in the reaction kettle is ensured, so that the production requirement of the next step can be ensured.
However, the existing reaction kettle for preparing the biological medicine has the following defects: when the medicine materials are stirred, the materials in the reaction kettle are stirred by adopting a stirring device, dead angles exist in stirring, and the stirring is uneven and full; the heating device is usually arranged on the outer wall, so that the central position in the kettle cannot be heated, and the heating is uneven; the reaction rate is low, the use effect is poor, and therefore, the chiral amine drug intermediate catalytic reaction device is provided.
Disclosure of Invention
The invention aims to provide a chiral amine drug intermediate catalytic reaction device to solve the problems in the background technology.
In order to achieve the above purpose, the present invention provides the following technical solutions: the utility model provides a chiral amine medicine intermediate catalytic reaction device, includes the processing frame that is the rectangle in shape, the processing frame hangs reation kettle between upper and lower diagonal, reation kettle bottom middle part swivelling joint has outer rotatory bucket, a plurality of apopores have been seted up on the outer rotatory bucket, outer rotatory bucket bottom fixed mounting has the bottom plate, bottom plate inner circle sliding connection has the fixed plate, swivelling joint has the rotatory bucket on the fixed plate, and the transmission is connected with drive arrangement between outer rotatory bucket and the rotatory bucket, drive arrangement is used for driving outer rotatory bucket and the rotatory bucket constant speed counter-rotation; the inner rotary barrel outer ring is fixedly provided with a plurality of scooping parts, the inner rotary barrel outer ring is provided with a plurality of water diversion grooves, each water diversion groove is movably connected with a plurality of dispersing devices for dispersing the medicament, and the driving device drives the dispersing devices to stir water in the inner rotary barrel; the driving device comprises a second universal coupling fixedly arranged at one side of the bottom of the processing frame, one end of the second universal coupling is fixedly connected with a transmission rod, the transmission rod extends between an outer rotary barrel and an inner rotary barrel, a gear is fixedly arranged at one end of the transmission rod, a first toothed ring is fixedly arranged near the gear on the inner ring of the outer rotary barrel, a second toothed ring is arranged at the position corresponding to the first toothed ring on the outer ring of the inner rotary barrel, and the other end of the second universal coupling is fixedly connected with an output shaft of a motor; the dispersing device comprises a plurality of fixing holes formed in the water diversion groove, fixing sleeves fixedly arranged on the fixing holes, movable rods are slidably connected to each fixing sleeve, limiting balls are fixed at one ends of the movable rods, sliding grooves are fixedly arranged at the bottoms of the movable rods, water disturbing plates are slidably connected to each sliding groove, a second spring is fixedly arranged at one end inside each sliding groove, the second spring is elastically abutted against the water disturbing plates, and a plurality of water stirring holes are randomly formed in each water disturbing plate; a plurality of fixed limiting rods are arranged between the fixed plate and the bottom plate, a plurality of arch balls are fixedly arranged on the bottom plate, and a transmission assembly for driving the water disturbing plate to move on the chute is movably connected to the transmission rod; the transmission assembly comprises a fixed sheet fixedly arranged on the transmission rod, a first spring is fixedly connected to one side of the fixed sheet, a connector connected with the first spring is connected to the transmission rod in a sliding manner, a poking plate is fixedly arranged on the outer ring of the connector beside the bottom of the inwards-rotating barrel, a push rod penetrating through the bottom of the inwards-rotating barrel is fixedly arranged at one end of the poking plate, and the push rod is in contact with one end of the water disturbing plate; the outer ring of the inner rotary barrel is provided with a plurality of impellers with equal distance from each other, and the outer ring of the outer rotary barrel is provided with a spiral groove.
Preferably, the water inlet pipe and the water outlet pipe are respectively installed at the top and the bottom of the reaction kettle, a high-pressure hot gas supply pipe is connected to the water outlet pipe, the high-pressure hot gas supply pipe is connected with a water pump output port, the reaction kettle is fixedly provided with a first universal coupling at one end far away from a second universal coupling, the first universal coupling is fixedly connected with a processing frame, and the processing frame is fixedly connected with a fixing frame at the surface of the reaction kettle.
Preferably, the number of the water disturbing plates is at least 3, and the end parts of the water disturbing plates are close to each other to form a staggered state.
Preferably, a sealing ring is arranged at the joint of the transmission rod and the reaction kettle, and the length of the transmission rod does not exceed the height of the outer rotary barrel.
Preferably, the scoop is L-shaped and the scoop height is the lowest point distance between the outer rotating tub and the inner rotating tub surface.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, the reaction kettle is obliquely placed, the contact area of the medicament on the inner wall of the reaction kettle is increased, the intermediate catalytic reaction is facilitated, the quantitative medicament is filled in the top of the reaction kettle, after the motor is started, the motor shaft drives the transmission rod to rotate, the inner rotary barrel and the outer rotary barrel rotate at the same speed and in the opposite direction through the cooperation of the gear and the two toothed rings in the rotating process of the transmission rod, then the medicament on the surface of the outer rotary barrel is replaced into the inner rotary barrel through the water outlet in the rotating process of the outer rotary barrel, the medicament is subjected to sequential diversion on the outer surface of the inner rotary barrel, preliminary dispersion is performed in the inner rotary barrel, the medicament stirring and mixing efficiency is improved, and the intermediate catalytic reaction is facilitated;
when the rotary rod rotates, the bottom plate is synchronously driven to rotate, the arch ball is driven to contact with the connector when the bottom plate rotates, the connector slides on the transmission rod, the shifting piece is driven to lift when the connector moves, and when the shifting piece moves, the ejector rod is driven to extrude the water disturbing plate to move in the chute, so that the positions of each water stirring hole are not corresponding, a plurality of water disturbing plates are arranged, the water disturbing plates surround into a ring shape, water stirring holes are formed in the surfaces of the water disturbing plates, the medicines are further dispersed randomly, the stable flow state in a dispersing area in the process of dispersing the medicines by the equipment is prevented, and the continuous and unclear phenomenon of the dispersion among the medicines is caused again;
through the outside bailing portion of interior rotatory bucket, can make the medicament that is located reation kettle or outer rotatory bucket bottom can repeat the circulation dispersion, promote reaction rate.
Drawings
FIG. 1 is a schematic diagram of the overall structure of the present invention;
FIG. 2 is a schematic diagram of the internal structure of the reaction kettle;
FIG. 3 is a schematic view of the internal structure of an outer rotary tub with a processing frame according to the present invention;
FIG. 4 is a schematic view of the internal structure of the outer rotary tub according to the present invention;
FIG. 5 is a schematic illustration of the inner rotary tub and its associated structure of the present invention;
FIG. 6 is a schematic cross-sectional view of an outer rotary tub of the present invention;
FIG. 7 is an enlarged schematic view of the structure of FIG. 3A according to the present invention;
FIG. 8 is a schematic view of a dispersing device according to the present invention;
fig. 9 is a schematic diagram of a transmission assembly according to the present invention.
In the figure: 1. processing a frame; 2. a motor; 3. a fixing frame; 4. a reaction kettle; 5. a first universal coupling; 6. a second universal coupling; 7. a water outlet pipe; 8. a high pressure hot gas supply pipe; 9. an outer rotary tub; 901. a bottom plate; 902. arching balls; 903. fixing a limit rod; 10. a water outlet hole; 11. an inner rotary tub; 12. a connector; 13. a first spring; 14. a gear; 15. a fixing piece; 16. a first toothed ring; 17. a second toothed ring; 18. a scooping part; 19. a fixing hole; 20. a water diversion trench; 21. an impeller; 22. a fixed sleeve; 23. a movable rod; 24. a chute; 25. a second spring; 26. a water disturbing plate; 27. a pulling piece; 28. and (5) a push rod.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1-9, the present invention provides a technical solution: the utility model provides a chiral amine medicine midbody catalytic reaction device, including processing frame 1 that is the rectangle in shape, processing frame 1 hangs reation kettle 4 between upper and lower diagonal, reation kettle 4 bottom middle part swivelling joint has outer rotatory bucket 9, offer a plurality of apopores 10 on the outer rotatory bucket 9, outer rotatory bucket 9 bottom fixed mounting has bottom plate 901, bottom plate 901 inner circle sliding connection has fixed plate, rotatory bucket 11 of being connected with on the fixed plate, and the transmission between outer rotatory bucket 9 and the rotatory bucket 11 is connected with drive arrangement, drive arrangement is used for driving outer rotatory bucket 9 and the rotatory bucket 11 of internal rotation equi-speed counter-rotation, add moderate transaminase in reation kettle 4 during processing, and moderate catalytic agent medicament in the inside of reation kettle is rotatory bucket 9 and internal rotation bucket 11 is rotated, make outer rotatory bucket 9 drive bottom plate 901 rotate, wherein the fixed plate is located on reation kettle 4 and is fixed, connect with the axle between inner rotatory bucket 11 and the fixed plate, the bottom plate 11 has a toroidal slideway (does not draw the rotatory bucket 9 and the toroidal slideway of figure and can be with toroidal slideway assembly and the toroidal slideway 11 is the same purpose when rotatory and the toroidal slideway is dispersed in the bottom plate is rotated with the toroidal slideway 9 and the toroidal slideway 11 is rotated; when the medicament flows to the water outlet hole 10 along with the outer rotary barrel 9, the medicament overflows to the inside of the outer rotary barrel 9 along the water outlet hole 10, drops on the outer surface of the inner rotary barrel 11, and when the inner rotary barrel 11 and the outer rotary barrel 9 rotate along with the inner rotary barrel 11 and the outer rotary barrel 9, the medicament on the outer surface of the inner rotary barrel 11 is split by the inner rotary barrel 11, so that the medicament flows into the inner rotary barrel 11, and the medicament flowing position is adjusted by the dispersing device along with the rotation of the inner rotary barrel 11, so that the dispersing purpose is achieved;
further, the outer ring of the inner rotary barrel 11 is fixedly provided with a plurality of scooping parts 18, the outer ring of the inner rotary barrel 11 is fixedly provided with a plurality of impellers 21, the outer ring of the inner rotary barrel 11 is provided with a plurality of water diversion grooves 20, each water diversion groove 20 is movably connected with a plurality of dispersing devices for dispersing the medicament, the dispersing devices are driven by the driving devices to stir water in the inner rotary barrel 11, when the medicament at the bottom of the inner rotary barrel 11 is dispersed, in order to promote the dispersing effect, the medicament between the inner rotary barrel 11 and the outer rotary barrel 9 is brought to be higher along with rotation by the scooping parts 18 outside the inner rotary barrel 11 in the continuous rotation process, and then the medicament can be sequentially circulated along the outer wall of the inner rotary barrel 11 to achieve the good dispersing effect.
Specifically, the driving device comprises a second universal coupling 6 fixedly installed at one side of the bottom of the processing frame 1, one end of the second universal coupling 6 is fixedly connected with a transmission rod, the transmission rod extends between an outer rotary barrel 9 and an inner rotary barrel 11, one end of the transmission rod is fixedly provided with a gear 14, a first toothed ring 16 is fixedly installed near the gear 14 on the inner ring of the outer rotary barrel 9, a second toothed ring 17 is installed at the position corresponding to the first toothed ring 16 on the outer ring of the inner rotary barrel 11, the other end of the second universal coupling 6 is fixedly connected with an output shaft of a motor 2, when a medicament needs to be dispersed, the motor 2 is started, the output shaft of the motor 2 drives the transmission rod to rotate, the gear 14 is driven to rotate by the rotation of the transmission rod, the rotation of the gear 14 drives the first toothed ring 16 and the second toothed ring 17 to reversely rotate, the rotation paths of the outer rotary barrel 9 and the inner rotary barrel 11 are opposite, and large-area medicament contact on the surface of the inner rotary barrel 11 is facilitated.
Specifically, the dispersion device includes a plurality of fixed orifices 19 of seting up on the water diversion trench 20, fixed mounting is in fixed cover 22 on the fixed orifices 19, every fixed cover 22 is gone up sliding connection has movable rod 23, movable rod 23 one end is fixed with the spacing ball, a plurality of movable rod 23 bottom fixed mounting has spout 24, every sliding connection has the harassment board 26 on the spout 24, spout 24 inside one end fixed mounting has second spring 25, just second spring 25 and harassment board 26 elasticity are contradicted, every harassment board 26 is gone up and is all offered a plurality of harassment holes at random, when the internal rotation bucket 11 surface overflows the medicament to the internal rotation bucket 11 inside, later through harassment board 26, rotates with internal rotation bucket 11 through harassment water hole, in this process, when harassment board 26 is located the minimum between inner rotation bucket 11 and the outer rotation bucket 9 surface (both surfaces are comparatively near), because harassment board 26 is a plurality of movable rod 23 and carries out the fixed sphere that the traction rod 23 makes the inner rotation bucket 23 and the inner rotation bucket 9 and the spacing ball is located the inside the fixed barrel, and the inner rotation bucket 11 is located the inner rotation of the inner rotation bucket 11, and the inner rotation bucket is located the high-speed change the harassment board is because of the harassment board, wherein, and the inner rotation bucket 11 is located the inner rotation of the inner rotation bucket 11, the inner rotation of the harassment is more, the inner rotation bucket is high, the harassment is because of the harassment of the inner rotation bucket 11, the inner rotation of the inner rotation barrel 11.
Further, a plurality of fixed limit rods 903 are arranged between the fixed plate and the bottom plate 901, a plurality of arched balls 902 are fixedly arranged on the bottom plate 901, and a transmission assembly for driving the water disturbing plate 26 to move on the chute 24 is movably connected to the transmission rods; the transmission assembly comprises a fixed sheet 15 fixedly arranged on the transmission rod, a first spring 13 is fixedly connected to one side of the fixed sheet 15, a connector 12 connected with the first spring 13 is slidingly connected to the transmission rod, a shifting sheet 27 is fixedly arranged on the outer ring of the connector 12 beside the bottom of the inward rotating barrel 11, a push rod 28 penetrating through the bottom of the inward rotating barrel 11 is fixedly arranged at one end of the shifting sheet 27, the push rod 28 is contacted with one end of the water disturbing plate 26, after the unsteady movement of the water disturbing plates 26 forms a stable movement state, the influence on the fluid flowing direction is poor, so that the fluid flowing range and the fluid flowing direction are required to be changed continuously, the bottom plate 901 is synchronously driven to rotate when the transmission rod rotates, arch balls 902 are randomly distributed on the bottom plate 901, the arch balls 902 are driven to cut into the bottom of the connector 12 when the bottom plate 901 rotates, the connector 12 is lifted and moved on the transmission rod under the action of the first spring 13, and the push rod 28 is synchronously driven to lift when the connector 12 moves, so that the push rod 28 drives the water disturbing plate 26 to slide on the chute 24, the water disturbing plate 26 is required to change the fluid flowing range, and the fluid flowing range is prevented from being changed;
wherein the ejector rod 28 is designed to have a front end in a linear arc shape, so as to prevent interference between the inner rotary tub 11 and one end of the water disturbing plate 26 at other positions during rotation.
Further, inlet tube and outlet pipe 7 are installed respectively to reation kettle 4 top and bottom, be connected with high-pressure steam supply pipe 8 on the outlet pipe 7, high-pressure steam supply pipe 8 connects the water pump delivery outlet, reation kettle 4 is keeping away from the one end fixed mounting of second universal joint 6 and is having first universal joint 5, just first universal joint 5 and processing frame 1 fixed connection, processing frame 1 is at reation kettle 4 fixed surface connection has mount 3, for convenient control temperature, in outlet pipe 7 connection high-pressure steam supply pipe 8, when convenient dispersion for heat source equipment and this device separate, avoid appearing unexpected accident.
The outer ring of the inner rotary barrel 11 is provided with a plurality of impellers 21 with equal distance, the outer ring of the outer rotary barrel 9 is provided with spiral grooves, the impellers 21 are favorable for distributing medicines in the outer ring of the inner rotary barrel 11, and the spiral grooves are designed in the same way.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. The utility model provides a chiral amine medicine intermediate catalytic reaction device, includes processing frame (1) that the shape is rectangle, its characterized in that: a reaction kettle (4) is hung between the upper diagonal and the lower diagonal of the processing frame (1), an outer rotary barrel (9) is rotatably connected to the middle part of the bottom of the reaction kettle (4), a plurality of water outlet holes (10) are formed in the outer rotary barrel (9), a bottom plate (901) is fixedly arranged at the bottom of the outer rotary barrel (9), a fixing plate is slidingly connected to the inner ring of the bottom plate (901), an inner rotary barrel (11) is rotatably connected to the fixing plate, and a driving device is connected between the outer rotary barrel (9) and the inner rotary barrel (11) in a transmission manner and is used for driving the outer rotary barrel (9) and the inner rotary barrel (11) to rotate in a constant speed and reverse manner;
a plurality of scooping parts (18) are fixedly arranged on the outer ring of the inner rotary barrel (11), a plurality of water diversion grooves (20) are formed in the outer ring of the inner rotary barrel (11), a plurality of dispersing devices for dispersing the medicament are movably connected to each water diversion groove (20), and the driving device drives the dispersing devices to stir water in the inner rotary barrel (11);
the driving device comprises a second universal coupling (6) fixedly arranged at one side of the bottom of the processing frame (1), one end of the second universal coupling (6) is fixedly connected with a transmission rod, the transmission rod extends between an outer rotary barrel (9) and an inner rotary barrel (11), one end of the transmission rod is fixedly provided with a gear (14), a first toothed ring (16) is fixedly arranged near the gear (14) on the inner ring of the outer rotary barrel (9), a second toothed ring (17) is arranged at the position corresponding to the first toothed ring (16) on the outer ring of the inner rotary barrel (11), and the other end of the second universal coupling (6) is fixedly connected with an output shaft of the motor (2);
the dispersing device comprises a plurality of fixing holes (19) formed in the water diversion groove (20), fixing sleeves (22) fixedly mounted on the fixing holes (19), movable rods (23) are connected to each fixing sleeve (22) in a sliding mode, limiting balls are fixed to one ends of the movable rods (23), sliding grooves (24) are fixedly mounted at the bottoms of the movable rods (23), water disturbing plates (26) are connected to each sliding groove (24) in a sliding mode, a second spring (25) is fixedly mounted at one end inside each sliding groove (24), the second spring (25) elastically abuts against the water disturbing plates (26), and a plurality of water stirring holes are formed in each water disturbing plate (26) at random;
a plurality of fixed limiting rods (903) are arranged between the fixed plate and the bottom plate (901), a plurality of arch balls (902) are fixedly arranged on the bottom plate (901), and a transmission assembly for driving the water disturbing plate (26) to move on the chute (24) is movably connected to the transmission rod;
the transmission assembly comprises a fixing piece (15) fixedly mounted on the transmission rod, a first spring (13) is fixedly connected to one side of the fixing piece (15), a connector (12) connected with the first spring (13) is connected to the transmission rod in a sliding manner, a poking piece (27) is fixedly mounted on the outer ring of the connector (12) beside the bottom of the inwards-rotating barrel (11), a push rod (28) penetrating through the bottom of the inwards-rotating barrel (11) is fixedly mounted at one end of the poking piece (27), and the push rod (28) is in contact with one end of the water disturbing plate (26); the outer ring of the inner rotary barrel (11) is provided with a plurality of impellers (21) with equal distance, and the outer ring of the outer rotary barrel (9) is provided with a spiral groove.
2. The chiral amine drug intermediate catalytic reaction device according to claim 1, wherein: the utility model discloses a reaction kettle, including reation kettle (4), inlet tube, outlet pipe (7) are installed respectively to reation kettle (4) top and bottom, be connected with high-pressure steam supply pipe (8) on outlet pipe (7), high-pressure steam supply pipe (8) connect the water pump delivery outlet, reation kettle (4) are keeping away from one end fixed mounting of second universal joint (6) and have first universal joint (5), just first universal joint (5) and processing frame (1) fixed connection, processing frame (1) are at reation kettle (4) fixed surface connection have mount (3).
3. The chiral amine drug intermediate catalytic reaction device according to claim 1, wherein: the number of the water disturbing plates (26) is at least 3, and the end parts of the water disturbing plates (26) are mutually close to form a staggered state.
4. The chiral amine drug intermediate catalytic reaction device according to claim 1, wherein: the sealing ring is arranged at the joint of the transmission rod and the reaction kettle (4), and the length of the transmission rod is not more than the height of the outer rotary barrel (9).
5. The chiral amine drug intermediate catalytic reaction device according to claim 1, wherein: the scooping part (18) is L-shaped, and the height of the scooping part (18) is the lowest point distance between the surfaces of the outer rotary barrel (9) and the inner rotary barrel (11).
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| Application Number | Priority Date | Filing Date | Title |
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| CN202311512837.XA CN117225358B (en) | 2023-11-14 | 2023-11-14 | Chiral amine medicine intermediate catalytic reaction device |
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| CN101653668A (en) * | 2009-06-30 | 2010-02-24 | 优顿(天津)精细化工有限公司 | Batch type solid-liquid separating device |
| CN104801257A (en) * | 2015-04-01 | 2015-07-29 | 中国恩菲工程技术有限公司 | Replacement device |
| CN107415046A (en) * | 2015-08-14 | 2017-12-01 | 安徽固维特材料科技有限公司 | A kind of mixing method of modified engineering soil |
| CN105327762A (en) * | 2015-11-20 | 2016-02-17 | 左招霞 | Pulverizing machine |
| CN111068548A (en) * | 2019-12-27 | 2020-04-28 | 安徽正熹标王新能源有限公司 | Corrosion-resistant electrolyte stirring device |
| CN112452557A (en) * | 2020-11-02 | 2021-03-09 | 李丹 | Solid-liquid separation environmental protection processing apparatus for refuse and waste |
| CN214861352U (en) * | 2021-03-09 | 2021-11-26 | 威海职业学院(威海市技术学院) | Bio-pharmaceuticals active material separator |
| CN114345202A (en) * | 2022-01-13 | 2022-04-15 | 深圳市比创达电子科技有限公司 | Stirring device for chip production process |
| CN218429174U (en) * | 2022-08-17 | 2023-02-03 | 禹州市德通新材料有限公司 | Special mixer of recycled concrete preparation |
| CN218306634U (en) * | 2022-09-06 | 2023-01-17 | 邢台华佳助剂有限公司 | Filter material device is used in emulsifier production |
| CN115672104A (en) * | 2022-10-24 | 2023-02-03 | 山东京御堂制药有限公司 | Powder uniform stirring device |
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