CN117224623A - Snuff composition for treating irregular menstruation and preparation method and application thereof - Google Patents
Snuff composition for treating irregular menstruation and preparation method and application thereof Download PDFInfo
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
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Abstract
The invention discloses a nasal inhalation composition for treating irregular menstruation and a preparation method and application thereof, belonging to the field of medicines. The nasal inhalation composition comprises the following raw materials in parts by weight: 5-10 parts of motherwort extract, 16-19 parts of paeonia lactiflora root extract, 20-25 parts of Salvia miltiorrhiza oil, 13-15 parts of rose oil, 17-19 parts of nutmeg extract and 8-10 parts of crocus sativus oil. The nasal inhalation composition provided by the invention adopts specific component content to obtain the nasal inhalation composition with comfortable smell, and adopts a nasal inhalation mode to treat irregular menstruation, so that the nasal inhalation composition is convenient to use, and has high effectiveness in treating irregular menstruation.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to a nasal inhalation composition for treating irregular menstruation and a preparation method and application thereof.
Background
Primary dysmenorrhea (primary dysmenorrhea, PD), also known as functional dysmenorrhea, refers to a disease that occurs with menstrual cycles in lower abdominal pain without significant organic changes in the female genital organs. The disease is frequently seen in the female of the married teenager, and serious people can be accompanied with nausea and vomiting, cold sweat and dribbling cold hands and feet, even syncope, which affects work and life. The disease is high, the range is wide, the period is short, the pain is large, the work and the study of vast women are seriously influenced, the quality of life is reduced, and the physical and mental health of women is seriously influenced.
At present, irregular menstruation is mainly treated by three methods, namely, wearing type warming patches, such as a warming baby, a warming womb waistband and the like, but the wearing type warming patches temporarily relieve pain in a physical way of hot compress and cannot radically treat the pain; the second is health food such as dysmenorrhea tea, however, health food has slow effect and partial food has poor taste; and the third is taking analgesic drugs, non-steroidal anti-inflammatory drugs, oral contraceptives and the like, which have certain curative effects, but have a plurality of adverse reactions, such as central nervous system and gastrointestinal reactions, caused by the wide influence of the drugs on the metabolism of organisms. Therefore, there is a need to develop new drugs for treating menoxenia in a suitable industrialization.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a nasal inhalation composition for treating irregular menstruation and a preparation method and application thereof. The nasal inhalation composition provided by the invention avoids the defects of oral administration and injection medication, and has the characteristics of no pain, simplicity in operation, quick response, high curative effect, low price and the like.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: a nasal inhalation composition for treating irregular menstruation is prepared from the following raw materials in parts by weight: 5-10 parts of motherwort extract, 16-19 parts of paeonia lactiflora root extract, 20-25 parts of Salvia miltiorrhiza oil, 13-15 parts of rose oil, 17-19 parts of nutmeg extract and 8-10 parts of crocus sativus oil.
The invention follows the whole principle, based on the theory of traditional Chinese medicine and related research of dysmenorrheal pathogenesis, selects reasonable medicinal material compatibility formula, and combines all the medicines, thereby having the effects of activating blood circulation to dissipate blood stasis, warming channels to relieve pain, promoting qi circulation and relieving pain. In the formula, the motherwort extract is a monarch, plays roles of promoting blood circulation, removing blood stasis and relieving pain, and the paeonia lactiflora root extract and the rose oil are ministerial, cooperate with the motherwort extract, strengthen the roles of promoting blood circulation, removing blood stasis and relieving pain, and play roles of nourishing blood, astringing yin, dispelling cold and relieving pain; the Eurycoma longifolia oil is used as an adjuvant, and has the effects of relieving symptoms such as tension and anxiety caused by dysmenorrhea, and the nutmeg is used as a guiding ingredient, and has the effects of warming middle-jiao and promoting qi circulation. In addition, the odor of the nasal inhalation composition can be improved through the proportion, so that the nasal inhalation composition is comfortable, and the problem of poor odor of the nasal inhalation composition is solved.
In order to further improve the curative effect, the nasal inhalation composition is optimized, namely the proportion of the specific inhalation medicine is further optimized, and the nasal inhalation composition formed by the optimized proportion has a better treatment effect on dysmenorrheal, especially primary dysmenorrheal, and can promote blood circulation to remove blood stasis, warm meridians and relieve pain.
As a preferred embodiment of the nasal inhalation composition for treating irregular menstruation, the nasal inhalation composition for treating irregular menstruation is prepared from the following raw materials in parts by weight: 7-10 parts of motherwort extract, 17-19 parts of paeonia lactiflora root extract, 22-25 parts of Salvia miltiorrhiza Bunge oil, 13.5-14.5 parts of rose oil, 18-19 parts of nutmeg extract and 8.5-9.5 parts of crocus sativus oil.
As a preferred embodiment of the nasal inhalation composition for treating irregular menstruation, the nasal inhalation composition for treating irregular menstruation is prepared from the following raw materials in parts by weight: 7 parts of motherwort extract, 17.5 parts of paeonia lactiflora root extract, 23.5 parts of Salvia miltiorrhiza oil, 14 parts of rose oil, 18.5 parts of nutmeg extract and 9 parts of crocus sativus oil.
In order to further improve the curative effect, the invention optimizes the nasal inhalation composition, i.e. screens the preparation methods of motherwort extract and paeonia lactiflora extract, and uses supercritical CO 2 The extraction method can prepare the motherwort extract and the paeonia lactiflora root extract with high purity and active ingredients, and further improve the effect of the nasal inhalation composition. In addition, compared with other preparation methods, the extract of herba Leonuri and radix Paeoniae root is prepared by supercritical CO 2 The extract of herba Leonuri and radix Paeoniae can further improve smell of the nasal inhalation composition and use feeling of the nasal inhalation composition.
As a preferred embodiment of the nasal inhalation composition for treating irregular menstruation, the preparation method of the motherwort extract comprises the following steps: pulverizing herba Leonuri, sieving, adding supercritical CO 2 In the extraction tank, the extraction parameters are as follows: the pressure is 25-28MPa, the temperature is 35-40 ℃, the extraction time is 90-120min, and the CO is 2 The flow rate is 500-700L/min.
As bookAccording to the preferred embodiment of the nasal inhalation composition for treating irregular menstruation, the preparation method of the paeonia lactiflora root extract comprises the following steps of: pulverizing radix Paeoniae, sieving, adding supercritical CO 2 In the extraction tank, the extraction parameters are as follows: the pressure is 25-28MPa, the temperature is 35-40 ℃, the extraction time is 80-110min, and CO 2 The flow rate is 520-710L/min.
In the present invention, the Europe red sage oil, the rose oil, the nutmeg extract and the saffron oil can be prepared by a water extraction method which is conventional in the art.
The method comprises the following steps: soaking Saviae Miltiorrhizae radix, flos Rosae Rugosae, semen Myristicae, and stigma croci Sativi in 100deg.C water, cooling, and collecting upper oil respectively, namely Saviae Miltiorrhizae radix oil, folium Artemisiae Argyi extract, pelargonium graveolens oil, semen Myristicae extract, and stigma croci Sativi oil.
In order to further improve the effect of the nasal inhalation composition and shorten the acting time of the medicine, the invention optimizes and adjusts the soaking time, and specifically, the obtained soaking time is 2-3 hours.
Another object of the present invention is to provide a method for preparing the nasal inhalation composition for treating irregular menstruation, comprising the following steps: the following raw materials are uniformly mixed according to parts by weight: 5-10 parts of motherwort extract, 16-19 parts of peony extract, 20-25 parts of Salvia miltiorrhiza oil, 13-15 parts of rose oil, 17-19 parts of nutmeg extract and 8-10 parts of crocus sativus oil; thus obtaining the nasal inhalation composition for treating irregular menstruation.
It is another object of the present invention to provide the use of the nasal inhalation composition for treating menoxenia in the preparation of a product for treating menoxenia or alleviating menstrual syndromes.
It is still another object of the present invention to provide a nasal stick for treating menoxenia comprising the nasal stick composition for treating menoxenia.
The preparation method of the nasal inhalation stick for treating irregular menstruation comprises the following steps: the inner core of the nasal inhalation stick is placed in the nasal inhalation composition for soaking, and after the nasal inhalation composition is fully absorbed, the inner core is placed in the outer shell of the nasal inhalation stick, so that the nasal inhalation stick for treating irregular menstruation is obtained.
Compared with the prior art, the invention has the beneficial effects that:
(1) The nasal inhalation composition provided by the invention adopts specific component content to obtain the nasal inhalation composition with comfortable smell, and adopts a nasal inhalation mode to treat irregular menstruation, so that the nasal inhalation composition is convenient to use, and has high effectiveness in treating irregular menstruation.
(2) The nasal inhalation composition provided by the invention is a plant component, and is safe and independent.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples.
Example 1
The embodiment provides a nasal inhalation composition for treating irregular menstruation, which comprises the following raw materials in parts by weight: 7.05 parts of motherwort extract, 17.31 parts of paeonia lactiflora root extract, 23.72 parts of salvia miltiorrhiza oil, 14.10 parts of rose oil, 18.59 parts of nutmeg extract and 8.97 parts of crocus sativus oil;
the preparation method of the motherwort extract comprises the following steps: pulverizing herba Leonuri, sieving, adding supercritical CO 2 In the extraction tank, the extraction parameters are as follows: the pressure is 27MPa, the temperature is 38 ℃, the extraction time is 100min, and CO 2 The flow rate is 600L/min;
the preparation method of the paeonia lactiflora root extract comprises the following steps: pulverizing radix Paeoniae, sieving, adding supercritical CO 2 In the extraction tank, the extraction parameters are as follows: the pressure is 27MPa, the temperature is 38 ℃, the extraction time is 100min, and CO 2 The flow rate is 600L/min;
the preparation method of the Europe red sage oil, the rose oil, the nutmeg extract and the crocus sativus oil comprises the following steps: soaking Saviae Miltiorrhizae radix, flos Rosae Rugosae, semen Myristicae, and stigma croci Sativi in 100deg.C water for 3 hr, cooling, and collecting the upper layer oil respectively, namely Saviae Miltiorrhizae radix oil, folium Artemisiae Argyi extract, oleum Rosae Rugosae, semen Myristicae extract, and stigma croci Sativi oil.
The embodiment also provides a nasal inhalation stick for treating irregular menstruation, which comprises the following preparation method: the inner core of the nasal inhalation stick is placed in the nasal inhalation composition for soaking for 1h, and after the nasal inhalation composition is fully absorbed, the inner core is placed in the outer shell of the nasal inhalation stick, so that the nasal inhalation stick for treating irregular menstruation is obtained.
Example 2
The present embodiment provides a nasal inhalation composition for treating irregular menstruation, which is different from embodiment 1 in that the nasal inhalation composition for treating irregular menstruation comprises the following raw materials in parts by weight: 7 parts of motherwort extract, 17 parts of paeonia lactiflora root extract, 25 parts of Salvia miltiorrhiza oil, 13.5 parts of rose oil, 19 parts of nutmeg extract and 8.5 parts of crocus sativus oil.
The embodiment also provides a nasal inhalation stick for treating irregular menstruation, which comprises the following preparation method: the inner core of the nasal inhalation stick is placed in the nasal inhalation composition for soaking for 1h, and after the nasal inhalation composition is fully absorbed, the inner core is placed in the outer shell of the nasal inhalation stick, so that the nasal inhalation stick for treating irregular menstruation is obtained.
Example 3
The present embodiment provides a nasal inhalation composition for treating irregular menstruation, which is different from embodiment 1 in that the nasal inhalation composition for treating irregular menstruation comprises the following raw materials in parts by weight: 10 parts of motherwort extract, 19 parts of paeonia lactiflora root extract, 22 parts of Salvia miltiorrhiza oil, 15 parts of rose oil, 18 parts of nutmeg extract and 9.5 parts of crocus sativus oil.
The embodiment also provides a nasal inhalation stick for treating irregular menstruation, which comprises the following preparation method: the inner core of the nasal inhalation stick is placed in the nasal inhalation composition for soaking for 1h, and after the nasal inhalation composition is fully absorbed, the inner core is placed in the outer shell of the nasal inhalation stick, so that the nasal inhalation stick for treating irregular menstruation is obtained.
Example 4
The present embodiment provides a nasal inhalation composition for treating irregular menstruation, which is different from embodiment 1 in that the nasal inhalation composition for treating irregular menstruation comprises the following raw materials in parts by weight: 5 parts of motherwort extract, 19 parts of paeonia lactiflora root extract, 25 parts of Salvia miltiorrhiza oil, 13 parts of rose oil, 17 parts of nutmeg extract and 8 parts of crocus sativus oil.
The embodiment also provides a nasal inhalation stick for treating irregular menstruation, which comprises the following preparation method: the inner core of the nasal inhalation stick is placed in the nasal inhalation composition for soaking for 1h, and after the nasal inhalation composition is fully absorbed, the inner core is placed in the outer shell of the nasal inhalation stick, so that the nasal inhalation stick for treating irregular menstruation is obtained.
Example 5
The present embodiment provides a nasal inhalation composition for treating irregular menstruation, which is different from embodiment 1 in that the nasal inhalation composition for treating irregular menstruation comprises the following raw materials in parts by weight: 10 parts of motherwort extract, 16 parts of paeonia lactiflora root extract, 20 parts of Salvia miltiorrhiza oil, 15 parts of rose oil, 19 parts of nutmeg extract and 10 parts of crocus sativus oil.
The embodiment also provides a nasal inhalation stick for treating irregular menstruation, which comprises the following preparation method: the inner core of the nasal inhalation stick is placed in the nasal inhalation composition for soaking for 1h, and after the nasal inhalation composition is fully absorbed, the inner core is placed in the outer shell of the nasal inhalation stick, so that the nasal inhalation stick for treating irregular menstruation is obtained.
Comparative example 1
The comparative example provides a nasal inhalation composition for treating irregular menstruation, which is different from example 1 in that the nasal inhalation composition for treating irregular menstruation is composed of the following raw materials in parts by weight: 7.05 parts of motherwort extract, 17.31 parts of paeonia lactiflora root extract, 23.72 parts of salvia miltiorrhiza oil, 14.10 parts of pelargonium roseum oil, 18.59 parts of nutmeg extract and 8.97 parts of crocus sativus oil.
The comparative example also provides a nasal inhalation stick for treating irregular menstruation, which comprises the following preparation method: the inner core of the nasal inhalation stick is placed in the nasal inhalation composition for soaking for 1h, and after the nasal inhalation composition is fully absorbed, the inner core is placed in the outer shell of the nasal inhalation stick, so that the nasal inhalation stick for treating irregular menstruation is obtained.
Comparative example 2
The comparative example provides a nasal inhalation composition for treating irregular menstruation, which is different from example 1 in that the nasal inhalation composition for treating irregular menstruation is composed of the following raw materials in parts by weight: 7.05 parts of motherwort extract, 17.31 parts of paeonia lactiflora root extract, 23.72 parts of salvia miltiorrhiza oil, 10.26 parts of mugwort extract, 14.10 parts of geranium oil, 18.59 parts of nutmeg extract and 8.97 parts of crocus sativus oil.
The comparative example also provides a nasal inhalation stick for treating irregular menstruation, which comprises the following preparation method: the inner core of the nasal inhalation stick is placed in the nasal inhalation composition for soaking for 1h, and after the nasal inhalation composition is fully absorbed, the inner core is placed in the outer shell of the nasal inhalation stick, so that the nasal inhalation stick for treating irregular menstruation is obtained.
Effect example 1:
the treatment effect of the snuff bars obtained in example 1 (T1 group), comparative example 2 (T2 group) and the control group (C group) soaked with pure jojoba oil for 1 minute was tested.
106 patients with irregular menstruation were selected and randomly divided into a group C and a group T2, and 53 patients in each group were tested, wherein the ages of the patients were between 23 and 34 years, the tested persons in the group T1 and the group T2 were identical, and the test in the group T1 was performed 3 months after the test in the group T2 was completed.
The testing method comprises the following steps:
the nasal inhalation stick is used according to menstrual cycle of a patient, and is used from 7 days before menstrual cycle, 2 times per day for 10 minutes once; during menstrual period, 3 times per day, once for 10 minutes; within 7 days after menstrual period, 2 times per day, once for 10 minutes. Both groups of patients were treated with one month as one cycle, 3 menstrual cycles as one course of treatment, and 1 post-treatment statistical results.
And (3) observing the indexes:
the symptoms of pain in lower abdomen, soreness of waist, backache, aversion to cold, sweating, dizziness, nausea, vexation, general weakness and the like before and after treatment of the patient are observed, and the integral is 10 minutes full, and the higher the score is, the more serious the clinical symptoms of the patient are. Clinical effects of irregular menstruation: has obvious effects of recovering menstrual cycle and menstrual volume of a patient, and has no symptoms of abdominal pain, soreness of waist, backache and the like; effectively improves menstrual cycle and menstrual volume of patients, and relieves symptoms such as abdominal pain, soreness of waist and back pain; the failure is that the above symptoms of the patient are not achieved.
Statistical analysis:
in the study, 159 cases of irregular menstruation patients are input into SPSS19.0 software, and data before and after treatment of group C, group T1 and group T2 are analyzed by T-test on symptom integral data lines such as lower abdomen pain, waist soreness and back pain, cold aversion and sweating, dizziness and nausea, mental disorder, general weakness and the like, expressed by mean value +/-standard deviation and expressed by P. 3 groups of patients with irregular menstruation clinical curative effect are subjected to analysis of variance, and P <0.05 and P <0.01 are used as two groups of calibration base lines, and if the condition of P <0.05 is met, the difference is significant, and the data are expressed by single asterisks; extremely significant differences were observed when P <0.01 conditions were met, and double asterisks (x) indicated, were discussed as statistically significant for this study; the results are shown in tables 1-4.
Table 1C sets of pre-treatment and post-treatment data and statistical analysis results
Table 2 T1 group of pre-treatment and post-treatment data and statistical analysis results
Table 3T2 sets of pre-treatment and post-treatment data and statistical analysis results
Table 4 statistical analysis results of post-treatment data for T1 and T2 groups
From the experimental data in tables 1-4, the control group showed no significance (p > 0.05) for lower abdominal pain, soreness of waist, back pain, cold-aversion to sweating, dizziness, nausea, dysphoria, and general weakness before and after use; example 1 and comparative example 2 show significance (p < 0.05) for lower abdomen pain, soreness of waist and back pain, cold-afraid sweating, dizziness and nausea, dysphoria, general weakness before and after use, demonstrating that the nasal inhalation composition of the invention can effectively treat irregular menstruation; from the experimental data in tables 2 and 3, the test person did not continue to use the T2 group product 3 months after receiving the T2 group test, and the test person showed the same irregular menstruation as the test person before testing, indicating that the T2 group product was required to be used continuously.
Finally, it should be noted that the above-mentioned embodiments illustrate rather than limit the scope of the invention, and that those skilled in the art will understand that the technical scheme of the invention may be modified or equally substituted without departing from the spirit and scope of the technical scheme of the invention.
Claims (8)
1. The nasal inhalation composition for treating irregular menstruation is characterized by comprising the following raw materials in parts by weight: 5-10 parts of motherwort extract, 16-19 parts of paeonia lactiflora root extract, 20-25 parts of Salvia miltiorrhiza oil, 13-15 parts of rose oil, 17-19 parts of nutmeg extract and 8-10 parts of crocus sativus oil.
2. The nasal inhalation composition for treating irregular menstruation according to claim 1, which is composed of the following raw materials in parts by weight: 7-10 parts of motherwort extract, 17-19 parts of paeonia lactiflora root extract, 22-25 parts of Salvia miltiorrhiza Bunge oil, 13.5-14.5 parts of rose oil, 18-19 parts of nutmeg extract and 8.5-9.5 parts of crocus sativus oil.
3. The nasal inhalation composition for treating irregular menstruation according to claim 1, which is composed of the following raw materials in parts by weight: 7 parts of motherwort extract, 17.5 parts of paeonia lactiflora root extract, 23.5 parts of Salvia miltiorrhiza oil, 14 parts of rose oil, 18.5 parts of nutmeg extract and 9 parts of crocus sativus oil.
4. The nasal inhalation composition for treating irregular menstruation according to claim 1, wherein the motherwort herb extract is prepared by the following steps: pulverizing herba Leonuri, sieving, adding supercritical CO 2 In the extraction tank, the extraction parameters are as follows: the pressure is 25-28MPa, the temperature is 35-40 ℃, the extraction time is 90-120min, and the CO is 2 The flow rate is 500-700L/min.
5. The nasal inhalation composition for treating irregular menstruation according to claim 1, wherein the paeonia lactiflora root extract is prepared by the following steps: pulverizing radix Paeoniae, sieving, adding supercritical CO 2 In the extraction tank, the extraction parameters are as follows: the pressure is 25-28MPa, the temperature is 35-40 ℃, the extraction time is 80-110min, and CO 2 The flow rate is 520-710L/min.
6. A method of preparing a nasal inhalation composition for the treatment of menoxenia according to any one of claims 1 to 5 comprising the steps of: the following raw materials are uniformly mixed according to parts by weight: 5-10 parts of motherwort extract, 16-19 parts of peony extract, 20-25 parts of Salvia miltiorrhiza oil, 13-15 parts of rose oil, 17-19 parts of nutmeg extract and 8-10 parts of crocus sativus oil; thus obtaining the nasal inhalation composition for treating irregular menstruation.
7. Use of a nasal inhalation composition according to any one of claims 1 to 5 for the treatment of menoxenia in the manufacture of a product for the treatment of menoxenia or for the alleviation of menstrual syndromes.
8. A nasal stick for treating menoxenia, comprising a nasal composition for treating menoxenia according to any one of claims 1-5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311427202.XA CN117224623A (en) | 2023-10-31 | 2023-10-31 | Snuff composition for treating irregular menstruation and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202311427202.XA CN117224623A (en) | 2023-10-31 | 2023-10-31 | Snuff composition for treating irregular menstruation and preparation method and application thereof |
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| CN117224623A true CN117224623A (en) | 2023-12-15 |
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| CN202311427202.XA Pending CN117224623A (en) | 2023-10-31 | 2023-10-31 | Snuff composition for treating irregular menstruation and preparation method and application thereof |
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| CN (1) | CN117224623A (en) |
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