CN117222890A - 分析型hplc - Google Patents

分析型hplc Download PDF

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Publication number
CN117222890A
CN117222890A CN202280031268.4A CN202280031268A CN117222890A CN 117222890 A CN117222890 A CN 117222890A CN 202280031268 A CN202280031268 A CN 202280031268A CN 117222890 A CN117222890 A CN 117222890A
Authority
CN
China
Prior art keywords
mobile phase
organic solvent
acid
radiopharmaceutical
hplc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280031268.4A
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English (en)
Chinese (zh)
Inventor
A·克拉克
H·P·恩格尔布莱希特
J·格里格
I·A·可汗
K·维肯
G·麦克罗比
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN117222890A publication Critical patent/CN117222890A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/0093—Radioactive materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
    • G01N2030/8845—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds involving halogenated organic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8859—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
CN202280031268.4A 2021-04-26 2022-04-26 分析型hplc Pending CN117222890A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2105950.6 2021-04-26
GBGB2105950.6A GB202105950D0 (en) 2021-04-26 2021-04-26 Analytical HPLC
PCT/EP2022/061004 WO2022229155A1 (en) 2021-04-26 2022-04-26 Analytical hplc

Publications (1)

Publication Number Publication Date
CN117222890A true CN117222890A (zh) 2023-12-12

Family

ID=76193425

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280031268.4A Pending CN117222890A (zh) 2021-04-26 2022-04-26 分析型hplc

Country Status (12)

Country Link
US (1) US20240302338A1 (enExample)
EP (1) EP4330662B1 (enExample)
JP (1) JP2024518319A (enExample)
KR (1) KR20240000562A (enExample)
CN (1) CN117222890A (enExample)
AU (1) AU2022264815A1 (enExample)
CA (1) CA3217818A1 (enExample)
ES (1) ES3050308T3 (enExample)
GB (1) GB202105950D0 (enExample)
IL (1) IL307946A (enExample)
PL (1) PL4330662T3 (enExample)
WO (1) WO2022229155A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114555133A (zh) * 2019-10-21 2022-05-27 通用电气健康护理有限公司 环糊精作为放射稳定剂的用途
CN119688861A (zh) * 2024-11-29 2025-03-25 中国辐射防护研究院 一种生物样本中18f-psma-1007放化纯的液相色谱分析方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111333638A (zh) * 2020-03-17 2020-06-26 四川大学华西医院 18f标记的异喹啉并哒嗪酮类化合物及其合成方法和应用
CN112154130A (zh) * 2018-03-29 2020-12-29 通用电气健康护理有限公司 固相萃取

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
US5300280A (en) * 1992-02-14 1994-04-05 Mallinckrodt Medical, Inc. Stabilized radiopharmaceutical kits
ES2398393T3 (es) * 2002-03-01 2013-03-15 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico y terapia
JP4942953B2 (ja) * 2005-06-30 2012-05-30 サントリーホールディングス株式会社 プロシアニジンの分析方法
US8214159B2 (en) * 2008-12-04 2012-07-03 Siemens Medical Solutions Usa, Inc. Apparatus and method for automated quality control
GB201013808D0 (en) * 2010-08-18 2010-09-29 Ge Healthcare Ltd Peptide radiotracer compositions
EP2450332A1 (en) * 2010-10-22 2012-05-09 Bayer Pharma Aktiengesellschaft Compounds for use in Imaging, diagnosing and/or treatment of diseases of the central nervous system (F-D2-Deprenyl)
GB201202420D0 (en) * 2012-02-13 2012-03-28 Ge Healthcare Ltd Radiotracer compositions
CN104718299B (zh) * 2012-08-13 2024-02-06 通用医院公司 用于线粒体复合物i的定量定位的系统和方法
GB201303830D0 (en) * 2013-03-04 2013-04-17 Univ Glasgow Methods,unit and device relating to the manufacture,processing,synthesising or screening of radiopharmaceutical compositions
GB201418893D0 (en) * 2014-10-23 2014-12-10 Univ Hull Monolithic body

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112154130A (zh) * 2018-03-29 2020-12-29 通用电气健康护理有限公司 固相萃取
CN112154131A (zh) * 2018-03-29 2020-12-29 通用电气健康护理有限公司 稳定化的放射标记反应
CN111333638A (zh) * 2020-03-17 2020-06-26 四川大学华西医院 18f标记的异喹啉并哒嗪酮类化合物及其合成方法和应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李帅 等: "18F-Flurpiridaz 的制备及其在正常巴马小型猪PET/CT 心肌灌注显像中的初步实验研究", 国际放射医学核医学杂志, vol. 44, no. 03, 31 March 2020 (2020-03-31), pages 151 - 155 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114555133A (zh) * 2019-10-21 2022-05-27 通用电气健康护理有限公司 环糊精作为放射稳定剂的用途
CN114555133B (zh) * 2019-10-21 2025-02-11 通用电气健康护理有限公司 环糊精作为放射稳定剂的用途
CN119688861A (zh) * 2024-11-29 2025-03-25 中国辐射防护研究院 一种生物样本中18f-psma-1007放化纯的液相色谱分析方法

Also Published As

Publication number Publication date
KR20240000562A (ko) 2024-01-02
EP4330662A1 (en) 2024-03-06
EP4330662B1 (en) 2025-09-03
PL4330662T3 (pl) 2025-11-12
JP2024518319A (ja) 2024-05-01
IL307946A (en) 2023-12-01
ES3050308T3 (en) 2025-12-19
US20240302338A1 (en) 2024-09-12
CA3217818A1 (en) 2022-11-03
WO2022229155A1 (en) 2022-11-03
EP4330662C0 (en) 2025-09-03
AU2022264815A1 (en) 2023-10-26
GB202105950D0 (en) 2021-06-09

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