CN117203204A - 选择性血管紧张素ii受体配体 - Google Patents

选择性血管紧张素ii受体配体 Download PDF

Info

Publication number
CN117203204A
CN117203204A CN202280030667.9A CN202280030667A CN117203204A CN 117203204 A CN117203204 A CN 117203204A CN 202280030667 A CN202280030667 A CN 202280030667A CN 117203204 A CN117203204 A CN 117203204A
Authority
CN
China
Prior art keywords
compound
methyl
isobutyl
compounds
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280030667.9A
Other languages
English (en)
Chinese (zh)
Inventor
T·菲克斯
B·奥尔森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vicore Pharma AB
Original Assignee
Vicore Pharma AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vicore Pharma AB filed Critical Vicore Pharma AB
Publication of CN117203204A publication Critical patent/CN117203204A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202280030667.9A 2021-03-23 2022-03-23 选择性血管紧张素ii受体配体 Pending CN117203204A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB2104038.1A GB202104038D0 (en) 2021-03-23 2021-03-23 New compounds
GB2104038.1 2021-03-23
PCT/GB2022/050726 WO2022200786A1 (en) 2021-03-23 2022-03-23 Selective angiotensin ii receptor ligands

Publications (1)

Publication Number Publication Date
CN117203204A true CN117203204A (zh) 2023-12-08

Family

ID=75689746

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280030667.9A Pending CN117203204A (zh) 2021-03-23 2022-03-23 选择性血管紧张素ii受体配体

Country Status (7)

Country Link
US (1) US20240174657A1 (enExample)
EP (1) EP4313976A1 (enExample)
JP (1) JP2024511452A (enExample)
CN (1) CN117203204A (enExample)
CA (1) CA3212780A1 (enExample)
GB (1) GB202104038D0 (enExample)
WO (1) WO2022200786A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202104033D0 (en) * 2021-03-23 2021-05-05 Vicore Pharma Ab New compounds
GB2640807A (en) 2022-12-22 2025-11-05 Vicore Pharma Ab A method of treating a patient diagnosed with an interstitial lung disease
CN120569378A (zh) * 2023-01-09 2025-08-29 维科尔药物公司 选择性血管紧张素ii化合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040167176A1 (en) * 2001-05-31 2004-08-26 Mathias Alterman Tricyclic compounds useful as angiotensin II agonists
WO2021053344A1 (en) * 2019-09-20 2021-03-25 Vicore Pharma Ab New compounds
WO2022049372A1 (en) * 2020-09-01 2022-03-10 Vicore Pharma Ab Novel compounds for use in the treatment of diseases associated with angiotensin ii

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5312820A (en) 1992-07-17 1994-05-17 Merck & Co., Inc. Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines
US5444067A (en) 1993-08-30 1995-08-22 Merck & Co., Inc. Pharmaceutical treatment methods using angiotensin II receptor agonists bearing a thiophene moiety
SE9800550D0 (sv) 1998-02-24 1998-02-24 A & Science Invest Ab A pharmaceutical preparation comprising an angiotensin II type 2 receptor agonist, and use thereof
JP4707321B2 (ja) * 2001-05-31 2011-06-22 ヴィコール・ファルマ・アーベー アンギオテンシンｉｉアゴニストとして有用な三環式化合物
WO2003064414A1 (en) * 2002-01-29 2003-08-07 Vicore Pharma Ab. Tricyclic compounds useful as angiotensin ii agonists
WO2004046141A1 (en) 2002-11-21 2004-06-03 Vicore Pharma Ab New tricyclic angiotensin ii agonists
US8835471B2 (en) 2010-06-11 2014-09-16 Vicore Pharma Ab Use of angiotensin II agonists
SG11201704473WA (en) 2014-12-12 2017-06-29 Vicore Pharma Ab New methods and uses
WO2016107879A2 (en) 2014-12-30 2016-07-07 Vicore Pharma Ab New use of angiotensin ii receptor agonists
AU2016227486A1 (en) 2015-03-02 2017-08-17 Vicore Pharma Ab Angiotensin ll receptor agonist for treating pulmonary fibrosis
WO2017221012A1 (en) 2016-06-21 2017-12-28 Vicore Pharma Ab Methods and compositions for preventing or reducing the risk of cancer treatment-related cardiotoxicity
GB201710906D0 (en) 2017-07-06 2017-08-23 Vicore Pharma Ab Compounds and methods for treating peripheral neuropathy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040167176A1 (en) * 2001-05-31 2004-08-26 Mathias Alterman Tricyclic compounds useful as angiotensin II agonists
CN1529697A (zh) * 2001-05-31 2004-09-15 ά�ƶ�ҩ�﹫˾ 用作血管紧张素ⅱ激动剂的三环化合物
WO2021053344A1 (en) * 2019-09-20 2021-03-25 Vicore Pharma Ab New compounds
WO2022049372A1 (en) * 2020-09-01 2022-03-10 Vicore Pharma Ab Novel compounds for use in the treatment of diseases associated with angiotensin ii

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
XIONGYU WU ET AL.: "Selective angiotensin II AT2 receptor agonists: arylbenzylimidazole structure-activity relationships", J. MED. CHEM., vol. 49, 31 December 2006 (2006-12-31), pages 7160 - 7168 *

Also Published As

Publication number Publication date
CA3212780A1 (en) 2022-09-29
US20240174657A1 (en) 2024-05-30
EP4313976A1 (en) 2024-02-07
WO2022200786A1 (en) 2022-09-29
JP2024511452A (ja) 2024-03-13
GB202104038D0 (en) 2021-05-05

Similar Documents

Publication Publication Date Title
CN115605265B (zh) 用于治疗和/或预防与血管紧张素ii相关的疾病、病症或病状的新型化合物
WO2021053344A1 (en) New compounds
KR20230058467A (ko) 안지오텐신 ii와 관련된 질환의 치료에 사용하기 위한 신규한 화합물
EP4313976A1 (en) Selective angiotensin ii receptor ligands
US20250101010A1 (en) Selective angiotensin ii compounds
CN115666557A (zh) 用于治疗血管紧张素ii相关疾病的咪唑基噻吩磺酰基氨基甲酸酯
GB2605148A (en) New compounds
CN120569378A (zh) 选择性血管紧张素ii化合物
CN117242071A (zh) 选择性血管紧张素ii受体配体
EP4313953A1 (en) Selective angiotensin ii receptor ligands
CN117222624A (zh) 选择性血管紧张素ii受体配体
CN117916229A (zh) 新型选择性血管紧张素ii化合物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination