CN117158942A - Magnetic compatible contrast guide wire for treatment in MRI equipment - Google Patents
Magnetic compatible contrast guide wire for treatment in MRI equipment Download PDFInfo
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- CN117158942A CN117158942A CN202311135786.3A CN202311135786A CN117158942A CN 117158942 A CN117158942 A CN 117158942A CN 202311135786 A CN202311135786 A CN 202311135786A CN 117158942 A CN117158942 A CN 117158942A
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- core wire
- coating layer
- guide wire
- based polymer
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- 239000011247 coating layer Substances 0.000 claims abstract description 28
- 229920000642 polymer Polymers 0.000 claims abstract description 27
- 239000002184 metal Substances 0.000 claims abstract description 25
- 229910052751 metal Inorganic materials 0.000 claims abstract description 25
- 239000011248 coating agent Substances 0.000 claims abstract description 23
- 238000000576 coating method Methods 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 12
- 230000008569 process Effects 0.000 claims abstract description 8
- 238000007750 plasma spraying Methods 0.000 claims abstract description 7
- 150000002739 metals Chemical class 0.000 claims description 15
- 230000001225 therapeutic effect Effects 0.000 claims description 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 239000004677 Nylon Substances 0.000 claims description 3
- 229920002614 Polyether block amide Polymers 0.000 claims description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 3
- HZEWFHLRYVTOIW-UHFFFAOYSA-N [Ti].[Ni] Chemical compound [Ti].[Ni] HZEWFHLRYVTOIW-UHFFFAOYSA-N 0.000 claims description 3
- 239000010941 cobalt Substances 0.000 claims description 3
- 229910017052 cobalt Inorganic materials 0.000 claims description 3
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 3
- 229920001971 elastomer Polymers 0.000 claims description 3
- 239000000806 elastomer Substances 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 229910052742 iron Inorganic materials 0.000 claims description 3
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 3
- 239000011976 maleic acid Substances 0.000 claims description 3
- 229910001000 nickel titanium Inorganic materials 0.000 claims description 3
- 229920001778 nylon Polymers 0.000 claims description 3
- 239000011527 polyurethane coating Substances 0.000 claims description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims 1
- 238000003384 imaging method Methods 0.000 abstract description 13
- 230000005284 excitation Effects 0.000 abstract description 3
- 230000003902 lesion Effects 0.000 abstract description 3
- 210000004204 blood vessel Anatomy 0.000 abstract description 2
- 230000005865 ionizing radiation Effects 0.000 abstract description 2
- 210000005036 nerve Anatomy 0.000 abstract description 2
- 238000002595 magnetic resonance imaging Methods 0.000 description 15
- 239000007943 implant Substances 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
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- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 239000007769 metal material Substances 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 206010028851 Necrosis Diseases 0.000 description 1
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- 230000015572 biosynthetic process Effects 0.000 description 1
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- 238000010586 diagram Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
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- 238000004861 thermometry Methods 0.000 description 1
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- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
The invention discloses a magnetic compatible contrast guide wire for treatment in MRI equipment, which comprises a core wire, a water-based polymer coating layer coated outside the core wire, and a cylindrical elastic piece arranged between the core wire and the water-based polymer coating layer; the core wire is made of metal capable of cutting magnetic lines; a hydrophilic coating is arranged on the surface of the water-based polymer coating layer; the hydrophilic coating is sprayed on the water-based polymer coating layer through a plasma spraying process; the method has the advantages that no ionizing radiation is generated, MR perspective (real-time guiding operation) can be performed, puncture needle artifacts do not interfere with the target area, three-dimensional image reconstruction can be performed, the relationship between the target area and normal tissues can be clearly displayed, and the damage to nerves and blood vessels can be avoided to the greatest extent due to MR guiding; ultra-fast imaging sequences such as gradient echo (GRE), fast small angle excitation (FLASH) imaging, etc., MR images achieve near real-time display of interventional diagnostic images; the doctor can know the position relation between the surgical instrument and the lesion and the important tissue structure at any time, so that the complex operation is simpler and more convenient.
Description
Technical Field
The invention relates to the technical field of guide wires, in particular to a magnetic compatible contrast guide wire for treatment in MRI equipment.
Background
MRI, magnetic resonance imaging, is a non-invasive examination, and has become one of the indispensable imaging diagnostic methods in the current medical field; MRI has the advantages of good soft tissue resolution, non-invasive technology, no X-ray radiation damage, etc.
Interventional magnetic resonance (Interventional Magnetic Resonance), which is a new technology developed in recent years, can be used for diagnosing or treating diseases by using a magnetic resonance guiding instrument; as an interventional guidance tool, the magnetic resonance has the advantages incomparable with other imaging methods, has excellent tissue contrast and a spatial resolution reaching the sub-millimeter level, is beneficial to lesion positioning and interventional guidance, and more importantly, has the capabilities of multi-plane and three-dimensional volume reconstruction, and can comprehensively evaluate important anatomical relations between an interventional targeting region and adjacent tissues.
In the interventional operation process, doctors can approach patients at any time, and the development of an open magnet technology and the progress of a rapid imaging technology lead the interventional treatment under the guidance of magnetic resonance to be developed; the open magnetic resonance system has large imaging space, the operation can be performed in and out of the scanning area, and the operation can be scanned and monitored at any time, so that the operation condition can be observed in real time, and the working efficiency is greatly improved.
During MRI examination, implants made of various metal materials can cause serious artifacts in clinical examination, and the accuracy of disease diagnosis is reduced, wherein the artifacts are mainly represented by large low-signal areas at the metal implants or small high-signal areas at the edges and nearby of the metal implants, sometimes the high-signal areas extend backwards and upwards and the areas become smaller, so that adjacent tissues are also severely deformed and distorted; its generation has two reasons: firstly, the magnetic susceptibility of the metal implant is different from that of surrounding tissues, so that the local uniformity of a static magnetic field is destroyed, and the metal implant is a main cause of metal artifact; secondly, when the gradient coil is electrified to start and shut down, the metal implant generates induced current due to the change of the gradient field, which is also called vortex, and the linear relation between the proton nucleus and the gradient field is destroyed to cause irregular deformation of the image; with the increasing popularity of MRI devices, minimally invasive surgery such as tumor treatment with accurate positioning under MRI is becoming more and more mature. Therefore, research and development of novel medical metal materials and devices compatible with MRI has important clinical significance.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a magnetic compatible contrast guide wire for treatment in MRI equipment.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
a magnetic compatible contrast guide wire for therapeutic intervention in MRI equipment comprises a core wire, a water-based polymer coating layer coated outside the core wire and a cylindrical elastic piece arranged between the core wire and the water-based polymer coating layer; the core wire is made of metal capable of cutting magnetic lines; the surface of the water-based polymer coating layer is provided with a hydrophilic coating; the hydrophilic coating is sprayed on the aqueous polymer coating layer through a plasma spraying process.
Preferably, the aqueous polymer coating layer comprises a polyurethane coating layer, a nylon coating layer and a block polyether amide elastomer coating layer.
Preferably, the hydrophilic coating comprises a polyvinylpyrrolidone coating or a maleic acid coating.
Preferably, the two metals capable of cutting magnetic lines are mixed according to a certain proportion.
Preferably, the two metals capable of cutting magnetic lines may be metals capable of cutting magnetic lines such as iron, cobalt, nickel titanium, and the like.
Preferably, the method for preparing the guide wire comprises the following steps:
step S1, selecting two metals capable of cutting magnetic lines, and mixing according to a certain proportion to prepare a core wire;
s2, grinding one end of the core wire to make the core wire thinner;
step S3, coating the core wire after the step S2 with the water-based polymer;
and S4, spraying a hydrophilic coating on the aqueous polymer through a plasma spraying process.
Preferably, the core wire comprises two metals capable of cutting magnetic lines.
Compared with the prior art, the invention has the beneficial effects that:
the invention designs a magnetic compatible contrast guide wire for treatment, which is inserted into MRI equipment, has the advantages that ionizing radiation is not generated, MR perspective (real-time guiding operation) can be performed, puncture needle artifacts are not interfered to target areas, three-dimensional images can be reconstructed, MR image parameters have temperature dependence and in-vivo changes can be noninvasively detected, a Proton Resonance Frequency (PRF) method is a current thermometry gold standard, an ablation effect (T2 signal reduction can be used as one of coagulation necrosis marks) is immediately monitored and evaluated, tumor signal changes during puck formation and thermal ablation can be monitored in real time, arbitrary section imaging and multi-parameter imaging, multi-contrast imaging, functional imaging, soft tissue resolution and contrast are superior to CT, the relationship between the target areas and normal tissues can be clearly displayed, and the MR guiding can avoid nerve and blood vessel damage to the greatest extent; ultra-fast imaging sequences such as gradient echo (GRE), fast small angle excitation (FLASH) imaging, echo Planar Imaging (EPI), single excitation fast spin echo (SSFSE), etc., enable MR images to reach near real-time display of interventional diagnostic images, MRI is a gold standard for noninvasive assessment of cardiovascular structure and function; so that the surgeon can know the position relation between the surgical instrument and the lesion and the important tissue structure at any time, thereby leading the complex operation to be simpler and more visual.
Drawings
FIG. 1 is a schematic diagram of a structure according to the present invention;
FIG. 2 is a schematic flow chart of a method for preparing a guide wire according to the present invention
Legend description:
1. the core wire comprises a core wire body, a water-based polymer coating layer, a hydrophilic coating layer and a water-based polymer coating layer.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the description of the present invention, it should be noted that, directions or positional relationships indicated by terms such as "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., are based on directions or positional relationships shown in the drawings, are merely for convenience of description and simplification of description, and do not indicate or imply that the apparatus or element to be referred to must have a specific direction, be constructed and operated in the specific direction, and thus should not be construed as limiting the present invention; the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance; furthermore, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
Referring to fig. 1 to 2, a magnetic compatible contrast guide wire for therapeutic use is interposed in an MRI apparatus, and includes a core wire 1, an aqueous polymer coating layer 2 coated on the outside of the core wire 1, and a cylindrical elastic member provided between the core wire 1 and the aqueous polymer coating layer 2; the core wire 1 is made of metal capable of cutting magnetic lines; the surface of the water-based polymer coating layer 2 is provided with a hydrophilic coating layer 3; the hydrophilic coating 3 is sprayed onto the aqueous polymer coating 2 by a plasma spraying process.
Wherein the water-based polymer coating layer 2 comprises a polyurethane coating layer, a nylon coating layer and a block polyether amide elastomer coating layer, and the hydrophilic coating layer 3 comprises a polyvinylpyrrolidone coating layer or a maleic acid coating layer; the core wire 1 comprises two metals capable of cutting magnetic lines, and the two metals capable of cutting magnetic lines are mixed according to a certain proportion.
In one embodiment, the method of making a guidewire comprises the steps of: step S1, selecting two metals capable of cutting magnetic lines, and mixing according to a certain proportion to prepare a core wire; two metals with different proportions are selected for mixing, and the mixing proportion of the two metals can be different according to the field intensity of MRI equipment; s2, grinding one end of the core wire to make the core wire thinner; step S3, coating the core wire after the step S2 with the water-based polymer; and S4, spraying a hydrophilic coating on the aqueous polymer through a plasma spraying process. The two metals capable of cutting magnetic lines can be iron, cobalt, nickel titanium, etc.
The present invention is not limited to the above-mentioned embodiments, and any person skilled in the art, based on the technical solution of the present invention and the inventive concept thereof, can be replaced or changed within the scope of the present invention.
Claims (7)
1. A magnetic compatible contrast guide wire for therapeutic intervention in an MRI device, characterized by comprising a core wire, a water-based polymer coating layer coated outside the core wire, and a cylindrical elastic piece arranged between the core wire and the water-based polymer coating layer; the core wire is made of metal capable of cutting magnetic lines; the surface of the water-based polymer coating layer is provided with a hydrophilic coating; the hydrophilic coating is sprayed on the aqueous polymer coating layer through a plasma spraying process.
2. A magnetic compatible contrast guide wire for therapeutic use in an MRI apparatus according to claim 1, wherein the aqueous polymer coating comprises a polyurethane coating, a nylon coating, a block polyether amide elastomer coating.
3. A magnetic compatible contrast guide wire for therapeutic intervention in an MRI apparatus according to claim 1, wherein the hydrophilic coating comprises a polyvinylpyrrolidone coating or a maleic acid coating.
4. A magnetic compatible contrast guide wire for therapeutic intervention in an MRI apparatus according to claim 1, wherein the core wire comprises two metals capable of cutting magnetic lines of force.
5. A magnetic compatible contrast guide wire for therapeutic use in MRI apparatus according to claim 4, wherein the two metals capable of cutting magnetic lines of force are mixed in a certain proportion.
6. The magnetic compatible contrast guide wire for therapeutic use in MRI apparatus according to claim 5, wherein said two metals capable of cutting magnetic lines of force are iron, cobalt, nickel titanium, etc.
7. A magnetic compatible contrast guide wire for therapeutic intervention in an MRI apparatus according to claim 6, wherein the guide wire preparation method comprises the steps of:
step S1, selecting two metals capable of cutting magnetic lines, and mixing according to a certain proportion to prepare a core wire;
s2, grinding one end of the core wire to make the core wire thinner;
step S3, coating the core wire after the step S2 with the water-based polymer;
and S4, spraying a hydrophilic coating on the aqueous polymer through a plasma spraying process.
Priority Applications (1)
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CN202311135786.3A CN117158942A (en) | 2023-09-01 | 2023-09-01 | Magnetic compatible contrast guide wire for treatment in MRI equipment |
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CN202311135786.3A CN117158942A (en) | 2023-09-01 | 2023-09-01 | Magnetic compatible contrast guide wire for treatment in MRI equipment |
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CN117158942A true CN117158942A (en) | 2023-12-05 |
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CN202311135786.3A Pending CN117158942A (en) | 2023-09-01 | 2023-09-01 | Magnetic compatible contrast guide wire for treatment in MRI equipment |
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- 2023-09-01 CN CN202311135786.3A patent/CN117158942A/en active Pending
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