CN117158942A - Magnetic compatible contrast guide wire for treatment in MRI equipment - Google Patents

Abstract

The invention discloses a magnetic compatible contrast guide wire for treatment in MRI equipment, which comprises a core wire, a water-based polymer coating layer coated outside the core wire, and a cylindrical elastic piece arranged between the core wire and the water-based polymer coating layer; the core wire is made of metal capable of cutting magnetic lines; a hydrophilic coating is arranged on the surface of the water-based polymer coating layer; the hydrophilic coating is sprayed on the water-based polymer coating layer through a plasma spraying process; the method has the advantages that no ionizing radiation is generated, MR perspective (real-time guiding operation) can be performed, puncture needle artifacts do not interfere with the target area, three-dimensional image reconstruction can be performed, the relationship between the target area and normal tissues can be clearly displayed, and the damage to nerves and blood vessels can be avoided to the greatest extent due to MR guiding; ultra-fast imaging sequences such as gradient echo (GRE), fast small angle excitation (FLASH) imaging, etc., MR images achieve near real-time display of interventional diagnostic images; the doctor can know the position relation between the surgical instrument and the lesion and the important tissue structure at any time, so that the complex operation is simpler and more convenient.

Description

A kind of magnetic compatible contrast imaging guide wire for interventional treatment in MRI equipment

Technical field

The present invention relates to the technical field of guide wires, and in particular to a magnetically compatible imaging guide wire for interventional treatment in MRI equipment.

Background technique

MRI, or magnetic resonance resonance, is a non-invasive examination and has become one of the indispensable imaging diagnostic methods in the current medical field. MRI has the advantages of good soft tissue resolution, non-invasive technology, and no X-ray radiation damage.

Interventional Magnetic Resonance is a new technology developed in recent years. The use of magnetic resonance guidance equipment can achieve the purpose of diagnosing or treating diseases. As an interventional guidance tool, magnetic resonance has advantages that other imaging methods cannot match. Its tissue It has excellent contrast and sub-millimeter spatial resolution, which is beneficial to both lesion localization and interventional guidance. More importantly, magnetic resonance has the ability of multi-plane and three-dimensional volume reconstruction, which can comprehensively evaluate the important anatomy of the interventional target area and adjacent tissues. relation.

During interventional surgery, doctors must be able to be close to the patient at any time. The emergence of open magnet technology and the advancement of fast imaging technology have enabled the development of interventional treatments guided by magnetic resonance. The open magnetic resonance system has a large imaging space, and the surgery can be performed during the scan. It can be scanned and monitored at any time during the operation, both inside and outside the area, which not only facilitates real-time observation of the intraoperative situation, but also greatly improves work efficiency.

During MRI examination, implants of various metal materials will cause serious artifacts in clinical examinations, reducing the accuracy of disease diagnosis. This artifact mainly manifests as a large low-signal area at the metal implant, or its edges. There are small areas of high signal bands nearby. Sometimes these high signals will extend backward and upward and the area will become smaller, causing severe deformation and distortion of adjacent tissues. There are two reasons for its occurrence: First, metal implants The magnetic susceptibility of the object and the surrounding tissue is different, which destroys the local uniformity of the static magnetic field and is the main cause of metal artifacts; second, when the gradient coil is energized and turned off, the metal implant is cut due to changes in the gradient field. Induced current, also known as eddy current, destroys the linear relationship between the proton nucleus and the gradient field and causes irregular deformation of the image; with the gradual popularization of MRI equipment, minimally invasive surgeries such as precise positioning of tumor treatment under MRI are becoming more and more mature. . Therefore, research and development of new MRI-compatible medical metal materials and devices are of great clinical significance.

Contents of the invention

The purpose of the present invention is to propose a magnetically compatible imaging guidewire for interventional treatment in MRI equipment in order to solve the shortcomings existing in the prior art.

In order to achieve the above objects, the present invention adopts the following technical solutions:

A magnetically compatible imaging guidewire for interventional treatment in MRI equipment, including a core wire, a water-based polymer coating layer covering the outside of the core wire, and a water-based polymer coating layer provided between the core wire and the water-based polymer coating The cylindrical elastic member between the layers; the core wire is made of metal that can cut magnetic lines of force; the surface of the water-based polymer coating layer is provided with a hydrophilic coating; the hydrophilic coating is sprayed on the surface through a plasma spraying process on the water-based polymer coating layer.

Preferably, the water-based polymer coating layer includes a polyurethane coating layer, a nylon coating layer, and a block polyetheramide elastomer coating layer.

Preferably, the hydrophilic coating includes polyvinylpyrrolidone coating or maleic acid coating.

Preferably, the two metals capable of cutting magnetic lines of force are mixed in a certain proportion.

Preferably, the two metals capable of cutting magnetic lines of force may be iron, cobalt, nickel-titanium and other metals capable of cutting magnetic lines of force.

Preferably, the guidewire preparation method includes the following steps:

Step S1: Select two metals that can cut magnetic lines of force and mix them in a certain proportion to make core wire;

Step S2: Grind one end of the core wire to make it thin;

Step S3: Coat the core wire that has completed step S2 with a water-based polymer;

Step S4: Spray a hydrophilic coating on the water-based polymer through a plasma spraying process.

Preferably, the core wire includes two metals capable of cutting magnetic lines of force.

Compared with the prior art, the beneficial effects of the present invention are:

The present invention designs a magnetically compatible imaging guidewire for interventional treatment in MRI equipment, which has the following advantages: no ionizing radiation, can be used for MR fluoroscopy (real-time guided surgery), and puncture needle artifacts have no interference on the display of the targeted area. Three-dimensional image reconstruction, MR image parameters are temperature-dependent and can non-invasively detect changes in the body. The proton resonance frequency (PRF) method is the current gold standard for temperature measurement, which can immediately monitor and evaluate the ablation effect (reduced T2 signal can be used as one of the markers of coagulation necrosis ), which can monitor ice ball formation and tumor signal changes during thermal ablation in real time. Any section imaging and multi-parameter imaging, multi-contrast imaging, functional imaging, soft tissue resolution and contrast are better than CT, and can clearly show the relationship between the target area and normal tissue. , MR guidance can avoid nerve and blood vessel damage to the greatest extent; ultra-fast imaging sequences such as gradient echo (GRE), fast small angle excitation (FLASH) imaging, echo planar imaging (EPI), single shot fast spin echo (SSFSE) ), etc., enables MR images to display interventional diagnosis and treatment images in near real-time. MRI is the gold standard for non-invasive evaluation of cardiovascular structure and function; it enables surgeons to understand the positional relationship between surgical instruments, lesions, and important tissue structures at any time, thereby making complex The operation is simpler and more intuitive.

Description of drawings

Figure 1 is a schematic structural diagram of the invention;

Figure 2 is a schematic flow chart of the guidewire preparation method proposed by the present invention.

illustration:

1. Core wire, 2. Water-based polymer coating, 3. Hydrophilic coating.

Detailed ways

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of the present invention.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. The indicated orientation or positional relationship is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the present invention and simplifying the description. It does not indicate or imply that the device or element referred to must have a specific orientation or a specific orientation. construction and operation, and therefore cannot be construed as limitations of the present invention; the terms "first", "second" and "third" are used for descriptive purposes only and cannot be construed as indicating or implying relative importance; in addition, unless otherwise stated For clear provisions and limitations, the terms "installation", "connection" and "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, or it can be an integral connection. Electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, or it can be an internal connection between two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood on a case-by-case basis.

Referring to Figures 1 to 2, a magnetically compatible imaging guidewire for interventional treatment in MRI equipment includes a core wire 1, a water-based polymer coating 2 covering the outside of the core wire 1, and a guide wire located on the core wire 1. The cylindrical elastic member between 1 and the water-based polymer coating layer 2; the core wire 1 is made of metal that can cut magnetic lines of force; the surface of the water-based polymer coating layer 2 is provided with a hydrophilic coating 3; the hydrophilic coating 3 It is sprayed on the water-based polymer coating layer 2 through a plasma spraying process.

Among them, the water-based polymer coating layer 2 includes a polyurethane coating layer, a nylon coating layer, and a block polyether amide elastomer coating layer, and the hydrophilic coating 3 includes a polyvinylpyrrolidone coating or a maleic acid coating; the core Wire 1 includes two metals that can cut magnetic lines of force, and two metals that can cut magnetic lines of force are mixed in a certain proportion.

In a specific embodiment, the guide wire preparation method includes the following steps: Step S1, select two metals that can cut magnetic lines of force and mix them in a certain proportion to make a core wire; select two metals in different proportions to mix, which can be determined according to MRI The mixing ratio of the two metals can also be different if the field strength of the equipment is different; Step S2, grind one end of the core wire to make it thinner; Step S3, coat the core wire that has completed Step S2 with a water-based polymer; Step S4 , a hydrophilic coating is sprayed on the water-based polymer through a plasma spraying process. The two metals that can cut magnetic lines of force can be iron, cobalt, nickel-titanium and other metals that can cut magnetic lines of force.

The above are only preferred specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto. Any person familiar with the technical field can, within the technical scope disclosed in the present invention, use the technical solutions of the present invention and its Equivalent substitutions or changes of the inventive concept shall be included in the protection scope of the present invention.

Claims (7)

1. A magnetically compatible imaging guidewire for interventional treatment in MRI equipment, characterized in that it includes a core wire, a water-based polymer coating layer covering the outside of the core wire, and a coating layer between the core wire and the core wire. The cylindrical elastic member between the water-based polymer coating layers; the core wire is made of metal capable of cutting magnetic lines of force; a hydrophilic coating is provided on the surface of the water-based polymer coating layer; the hydrophilic coating It is sprayed on the water-based polymer coating layer through a plasma spraying process. 2. A kind of magnetically compatible imaging guide wire for interventional treatment in MRI equipment according to claim 1, characterized in that the water-based polymer coating layer includes a polyurethane coating layer, a nylon coating layer, and a block polyether coating. Amide elastomer coating. 3. A magnetically compatible contrast guide wire for interventional treatment in MRI equipment according to claim 1, characterized in that the hydrophilic coating includes polyvinylpyrrolidone coating or maleic acid coating. 4. A magnetically compatible imaging guidewire for interventional treatment in MRI equipment according to claim 1, characterized in that the core wire includes two metals capable of cutting magnetic lines of force. 5. A magnetically compatible imaging guidewire for interventional treatment in MRI equipment according to claim 4, characterized in that the two metals capable of cutting magnetic lines of force are mixed in a certain proportion. 6. A magnetically compatible imaging guidewire for interventional treatment in MRI equipment according to claim 5, characterized in that the two metals capable of cutting magnetic lines of force can be iron, cobalt, nickel-titanium and other metals capable of cutting magnetic lines of force. 7. A kind of magnetically compatible imaging guide wire for interventional treatment in MRI equipment according to claim 6, characterized in that the guide wire preparation method includes the following steps: Step S1: Select two metals that can cut magnetic lines of force and mix them in a certain proportion to make core wire; Step S2: Grind one end of the core wire to make it thin; Step S3: Coat the core wire that has completed step S2 with a water-based polymer; Step S4: Spray a hydrophilic coating on the water-based polymer through a plasma spraying process.