CN105268085A - Hydrophilic micro-guide wire for minimally-invasive intervention and manufacturing method of hydrophilic micro-guide wire - Google Patents
Hydrophilic micro-guide wire for minimally-invasive intervention and manufacturing method of hydrophilic micro-guide wire Download PDFInfo
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- CN105268085A CN105268085A CN201510759045.1A CN201510759045A CN105268085A CN 105268085 A CN105268085 A CN 105268085A CN 201510759045 A CN201510759045 A CN 201510759045A CN 105268085 A CN105268085 A CN 105268085A
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 7
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims abstract description 67
- 239000011248 coating agent Substances 0.000 claims abstract description 49
- 238000000576 coating method Methods 0.000 claims abstract description 49
- 229920000642 polymer Polymers 0.000 claims abstract description 20
- 229910052721 tungsten Inorganic materials 0.000 claims description 62
- 239000010937 tungsten Substances 0.000 claims description 62
- 239000000463 material Substances 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 8
- 229920002635 polyurethane Polymers 0.000 claims description 8
- 239000004814 polyurethane Substances 0.000 claims description 8
- 238000000227 grinding Methods 0.000 claims description 7
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 6
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 6
- 239000011976 maleic acid Substances 0.000 claims description 6
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 6
- 239000004677 Nylon Substances 0.000 claims description 5
- 229920002614 Polyether block amide Polymers 0.000 claims description 5
- 229920001778 nylon Polymers 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 4
- 229920001971 elastomer Polymers 0.000 claims description 3
- 239000000806 elastomer Substances 0.000 claims description 3
- 210000004204 blood vessel Anatomy 0.000 abstract description 13
- 229910001000 nickel titanium Inorganic materials 0.000 abstract description 8
- 230000002792 vascular Effects 0.000 abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 7
- 230000008901 benefit Effects 0.000 abstract description 5
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 229910001285 shape-memory alloy Inorganic materials 0.000 abstract description 5
- 238000002560 therapeutic procedure Methods 0.000 abstract description 5
- 230000007794 irritation Effects 0.000 abstract description 2
- HZEWFHLRYVTOIW-UHFFFAOYSA-N [Ti].[Ni] Chemical compound [Ti].[Ni] HZEWFHLRYVTOIW-UHFFFAOYSA-N 0.000 abstract 3
- 239000011247 coating layer Substances 0.000 abstract 3
- 238000003466 welding Methods 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 description 7
- 239000002184 metal Substances 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 5
- 239000010935 stainless steel Substances 0.000 description 5
- 229910001220 stainless steel Inorganic materials 0.000 description 5
- 229910045601 alloy Inorganic materials 0.000 description 4
- 239000000956 alloy Substances 0.000 description 4
- 238000005253 cladding Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000007334 memory performance Effects 0.000 description 4
- 229940030225 antihemorrhagics Drugs 0.000 description 3
- 238000005452 bending Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000000025 haemostatic effect Effects 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 241000209140 Triticum Species 0.000 description 2
- 235000021307 Triticum Nutrition 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000013152 interventional procedure Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000010902 straw Substances 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000009443 Vascular Malformations Diseases 0.000 description 1
- 238000002583 angiography Methods 0.000 description 1
- 210000001627 cerebral artery Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 1
- 239000011527 polyurethane coating Substances 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 206010055031 vascular neoplasm Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/16—Materials with shape-memory or superelastic properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09058—Basic structures of guide wires
- A61M2025/09083—Basic structures of guide wires having a coil around a core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09133—Guide wires having specific material compositions or coatings; Materials with specific mechanical behaviours, e.g. stiffness, strength to transmit torque
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention discloses a hydrophilic micro-guide wire for minimally-invasive intervention and a manufacturing method of the hydrophilic micro-guide wire. The hydrophilic micro-guide wire comprises a nickel-titanium memory alloy wire core rod, a tungsten-wire spring and a water-based polymer outer coating layer, wherein a conical spring sleeving part is disposed at the front end of the nickel-titanium memory alloy wire core rod, the tungsten-wire spring sleeves the spring sleeving part, and the front end and the rear end of the tungsten-wire spring are fixed on the spring sleeving part through laser welding; the water-based polymer outer coating layer sleeves the nickel-titanium memory alloy wire core rod and the tungsten-wire spring after the tungsten-wire spring sleeves the spring sleeving part; a hydrophilic coating coats the surface of the water-based polymer outer coating layer. The novel hydrophilic micro-guide wire applicable to clinical interventional therapy has the excellent pushing performance of a spring micro-guide wire, has extremely good X-ray traceability, and has the advantages of small vascular irritation, good blood and biological compatibility and easiness in blood vessel passing of a polymer super-smooth micro-guide wire.
Description
Technical field
The present invention relates to medical apparatus and instruments, relate to a kind of Wicresoft specifically and get involved with hydrophilic micro-wire and preparation method thereof.
Background technology
Micro-wire is, in minimally-invasive vascular intervenien therapy technology, the intervention devices such as microtubular are guided through sinuous tortuous thin vessels, enters the important interventional medicine apparatus of target site Endovascular.When the little supply vessels etc. guiding super-selective to enter in the coronary artery of coronary heart disease, cerebral arteries, vascular malformation and tumor tumor that intracranial is tiny, play irreplaceable guiding function.
Desirable micro-wire, from performance, requires that it pushes performance good, and due to micro-wire diameter tiny, also require in bending blood vessel by and push time not easily bend after distortion; Because micro-wire is thin and long, micro-wire front end is required to be easy to import blood vessel and by vascular bending section; Because thin vessels tube wall strength is little, micro-wire must reduce surperficial generation the with blood vessel wall as far as possible and rub and possibility injured blood vessel wall.
Summary of the invention
For deficiency of the prior art, the technical problem to be solved in the present invention there are provided a kind of Wicresoft and gets involved with hydrophilic micro-wire and preparation method thereof.
For solving the problems of the technologies described above, the present invention is realized by following scheme:
A kind of Wicresoft gets involved and uses hydrophilic micro-wire, and this micro-wire comprises: Ultimum Ti wire rod plug, tungsten filament spring, waterborne polymeric external coating; Described Ultimum Ti wire core nose is provided with one section of spring socket part, and described spring socket part is tapered, and described tungsten filament spring is placed on spring housing and connects in portion, and the rear and front end of tungsten filament spring is fixed on spring socket part by laser weld; Described tungsten filament spring is placed on after spring housing meets portion, has one deck waterborne polymeric external coating at Ultimum Ti wire rod plug and tungsten filament spring outer cover; Described waterborne polymeric external coating surface scribbles one deck hydrophilic coating.
Further, described waterborne polymeric external coating comprises polyurethane clad, nylon bag coating, block polyetheramides elastomer clad.
Further, described hydrophilic coating comprises PVP hydrophilic coating, maleic acid hydrophilic coating.
Further, the diameter of described Ultimum Ti wire rod plug is 0.5mm, and its entire length is 150cm, and the length of the volute spring socket part of Ultimum Ti wire core nose is 30cm, and the end diameter of described spring socket part is 0.15mm.
Further, the wire diameter of described tungsten filament spring is between 0.03 ~ 0.05mm, and the internal diameter of tungsten filament spring is 0.3mm, and the length of described tungsten filament spring (2) is less than spring socket part 3cm.
Wicresoft gets involved the manufacture method with hydrophilic micro-wire, and manufacture method comprises the following steps:
1), material prepares:
Length is 1, the Ultimum Ti wire rod of 150cm, external diameter 0.5mm;
Diameter is 1, tungsten filament between 0.03 ~ 0.05mm;
2) be, by length 150cm, Ultimum Ti wire rod one end of external diameter 0.5mm sends between the Grinding wheel of coreless grinding machine and guide wheel, be ground to the tapering gradually thin segment of front end 30cm, the external diameter foremost of this gradually thin segment is 0.15mm;
3), by the tungsten filament of diameter between 0.03 ~ 0.05mm at external diameter be 0.3mm plug on turn to tungsten filament spring;
4), get above-mentioned steps 3) in tungsten filament its length 12cm, be inserted in from the levigate end of Ultimum Ti wire rod, tungsten filament spring front and back end laser weld is fixed;
5), the above-mentioned Ultimum Ti wire rod being wound with tungsten filament spring through being equipped with " T " coating mould, and the rear that the coated external diameter of mouth mould is " T " coating mould of the tube extruding machine of 0.8mm is sent into mouth and is sent into, and makes coated one layer of polymeric outside it;
6), with commercial medical polymer hydrophilic coating in above-mentioned steps 5) product on coating one thin hydrophilic coating.
The present invention adopts Ultimum Ti wire rod to be about the long tapering gradually thin segment of 30cm through being ground to front end, after the bend fixing of front end, be 30cm by length, internal diameter is greater than the tungsten filament spring housing that can be inserted in smoothly in this micro-wire tapering gradually full section of thin segment, make the NiTi wire rod front end that just tapering is gradually thin originally become the micro-wire front end that cover has Tungsten coil.Then adopt wire cladding technology, have the micro-wire front end of tungsten filament spring and full section coated polymer at this cover, as polyurethane or nylon, Pebax etc., become the micro-wire that full section is wrapped by.Then PVP, maleic acid or other hydrophilic high mols can be cross-linked and form hydrophilic coating at polymer surfaces by the later stage.
The present invention adopts memorial alloy micro-wire wire rod, tungsten filament, polymeric material to form micro-wire.Its construction features are, memory alloy wire is in conjunction with tungsten filament spring as micro-wire plug, and in this plug, memorial alloy super-elasticity and memory performance are in conjunction with the tungsten filament spring on the levigate end of tapering, and propelling movement and handling are significantly promoted; The polymer then Wheat straw mulching metal wire rod that this mandrel outer is coated, makes it greatly reduce the probability of the stimulation of blood vessel and injured blood vessel inwall.Another advantage of polymer outer cladding is very easily in coated hydrophilic high molecular material, and its hydrophilic and blood compatibility is obviously improved, and interventional procedure is also easy to carry out because micro-wire is hydrophilic.
Relative to prior art, the invention has the beneficial effects as follows: the present invention introduces the micro-wire that a kind of external diameter being applied to clinical vascular intervenien therapy is equal to or less than 0.5 millimeter.This micro-wire has Ultimum Ti plug by interior, and its front end has the tapering gradually thin segment reaching 30 centimetres; Gradually thin segment cover covers that x-ray development Tungsten coil, elastomeric polymer outer layer are coated, surface hydrophilic coating makes.The super-elasticity of Nitinol makes this micro-wire have excellent propelling movement performance, be easy to enter microtubular and the tortuous thin vessels that wriggles, the Tungsten coil that length is nearly 30 centimetres not only gives this micro-wire fabulous x-ray traceability, and greatly improve micro-wire front end pass through performance; Outer aqueous polyurethane is coated makes, blood minimum to blood vessel irritation and the good biocompatibility of micro-wire; The hydrophilic coating outside aqueous polyurethane on top layer more improves the smooth performance in thin vessels.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is that Ultimum Ti wire rod front end of the present invention is ground to tapering gradually thin step schematic diagram.
Fig. 2 is Tungsten coil coiling step schematic diagram of the present invention.
Fig. 3 be the present invention the grinding of NiTi wire rod gradually taper end be inserted in and fix tungsten filament spring schematic diagram.
Fig. 4 is that cover of the present invention has the Ultimum Ti plug of Tungsten coil to be wrapped by one layer of polymeric.
Labelling in accompanying drawing: Ultimum Ti wire rod plug 1, tungsten filament spring 2, plug 3, waterborne polymeric external coating 4.
Detailed description of the invention
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are described in detail, can be easier to make advantages and features of the invention be readily appreciated by one skilled in the art, thus more explicit defining is made to protection scope of the present invention.
Please refer to accompanying drawing 1 ~ 4, a kind of Wicresoft of the present invention gets involved and uses hydrophilic micro-wire, and this micro-wire comprises: Ultimum Ti wire rod plug 1, tungsten filament spring 2, waterborne polymeric external coating 4; Described Ultimum Ti wire rod plug 1 front end is provided with one section of spring socket part, and described spring socket part is tapered, and described tungsten filament spring 2 is placed on spring socket part, and the rear and front end of tungsten filament spring 2 is fixed on spring socket part by laser weld; After described tungsten filament spring 2 is placed on spring socket part, there is one deck waterborne polymeric external coating 4 at Ultimum Ti wire rod plug 1 and tungsten filament spring 2 outer cover; Described waterborne polymeric external coating 4 surface scribbles one deck hydrophilic coating.Described waterborne polymeric external coating 4 comprises polyurethane clad, nylon bag coating, block polyetheramides elastomer clad.Described hydrophilic coating comprises PVP hydrophilic coating, maleic acid hydrophilic coating, the diameter of described Ultimum Ti wire rod plug 1 is 0.5mm, its entire length is 150cm, the length of the volute spring socket part of Ultimum Ti wire rod plug 1 front end is 30cm, the end diameter of described spring socket part is 0.15mm, the wire diameter of described tungsten filament spring 2 is between 0.03 ~ 0.05mm, and the internal diameter of tungsten filament spring 2 is 0.3mm, and the length of described tungsten filament spring (2) is less than spring socket part 3cm.
The present invention is applied to the manufacture method of the Novel interventional therapy micro-wire in clinical vascular, and this manufacture method comprises the following steps:
1, material prepares:
Length is 1, the Ultimum Ti wire rod of 150cm, external diameter 0.5mm;
Diameter is 1, tungsten filament between 0.03 ~ 0.05mm;
2, be 150cm by length, Ultimum Ti wire rod one end of external diameter 0.5mm sends between the Grinding wheel of coreless grinding machine and guide wheel, is ground to the tapering gradually thin segment of front end 30cm, and the external diameter foremost of this gradually thin segment is 0.15mm;
3, by the tungsten filament of diameter between 0.03 ~ 0.05mm at external diameter be 0.3mm plug 3 on turn to tungsten filament spring;
4, get the tungsten filament spring 2 length 12cm in above-mentioned steps 3, be inserted in from the levigate end of Ultimum Ti wire rod, tungsten filament spring 2 front and back end laser weld is fixed;
5, the above-mentioned Ultimum Ti wire rod being wound with tungsten filament spring is through being equipped with " T " coating mould, and the rear that the coated external diameter of mouth mould is " T " coating mould of the tube extruding machine of 0.8mm is sent into mouth and sent into, and makes coated one layer of polymeric outside it;
6, on the product of above-mentioned steps 5, a thin hydrophilic coating is applied with commercial medical polymer hydrophilic coating.
Micro-wire constructs: micro-guide wire inner core, has metal wire rod as the plug in the middle of micro-wire.There is the tapering gradually thin segment of 30 centimetres the front end of metal wire rod plug, makes micro-wire leading portion have compliance; Gradually carefully overlap with metal wire rod turn, with compensate micro-wire leading portion due to wire rod gradually thin after propelling movement decline and strengthen its compliance.
Micro-wire is outer, adopts aqueous polyurethane coating to form complete polymer overmold, in order to the contact of isolating metal wire rod with blood vessel wall, avoids the direct and vessel wall contact of metal wire rod to reduce the vascular stimulation and infringement that may occur.
Micro-wire top layer, hydrophilic high mol process is carried out on top layer, its surface is gathered and forms the hydration top layer of pole low-friction coefficient.
Micro-wire constructs: because Ultimum Ti wire rod has super-elasticity and memory performance, not easily occur bending and deformation when very little angle of bend, adopt Ultimum Ti silk to have great superiority as the stainless steel silk of the more traditional use of mandrel material, the micro-wire of making will be beneficial to by thin vessels tortuous in body.Because tungsten filament wire rod has the better intensity of comparatively stainless steel silk, and have extremely excellent x-ray to follow the trail of display performance, plug tapering gradually thin segment selects Tungsten coil to be inserted in enhancing its propelling movement property, compliance, and shows tracking performance under improving the x-ray of micro-wire.
External coating selection-be applicable to the aqueous medical high polymer making vessel catheter and micro-wire clad material, as water-base polyurethane material.
Top layer is hydrophilic-and the good and the most frequently used hydrophilic high molecular material of Biocompatibility is PVP, and other are as the maleic acid also surperficial hydrophilic coating material of optional work.Author feels that in real work PVP is best selection.
Ultimum Ti micro-wire in material because its excellent super-elasticity and memory performance are better than stainless steel spring micro-wire; Structurally, the gradually thin front end sleeve of tapering, with turn spline structure, makes micro-wire obviously exceed only with the NiTi superslide micro-wire of polymer overmold front end in propelling movement performance and override capability.On micro-wire surface, the polymer on Ultimum Ti micro-wire surface is easy to apply water wetted material, thus reaches the effect that surperficial superslide blood and biocompatibility significantly promote.The constructional advantage of comprehensive two class micro-wire, the Novel interventional therapy micro-wire adopting new method to make, will can be that clinical intervention medical treatment provides novel, safety, performance better interventional medicine micro-wire equipment.
The present invention adopts Ultimum Ti wire rod to be about the long tapering gradually thin segment of 30cm through being ground to front end, after the bend fixing of front end, be 30cm by length, internal diameter is greater than the tungsten filament spring housing that can be inserted in smoothly in this micro-wire tapering gradually full section of thin segment, make the NiTi wire rod front end that just tapering is gradually thin originally become the micro-wire front end that cover has Tungsten coil.
Then adopt wire cladding technology, have the micro-wire front end of Tungsten coil and full section coated polymer at this cover, as polyurethane or nylon, Pebax etc., become the micro-wire that full section is wrapped by.Then PVP, maleic acid or other hydrophilic high mols can be cross-linked and form surface hydrophilic coating at polymer surfaces by the later stage.
The present invention adopts memorial alloy micro-wire wire rod, tungsten filament, polymeric material to form micro-wire.Its construction features are, memory alloy wire is in conjunction with tungsten filament spring as micro-wire plug, and in this plug, memorial alloy super-elasticity and memory performance are in conjunction with the tungsten filament spring on the levigate end of tapering, and propelling movement and handling are significantly promoted; The polymer then Wheat straw mulching metal wire rod that this mandrel outer is coated, makes it greatly reduce the probability of the stimulation of blood vessel and injured blood vessel inwall.Another advantage of polymer outer cladding is very easily in coated hydrophilic high molecular material, and its hydrophilic and blood compatibility is obviously improved, and interventional procedure is also easy to carry out because micro-wire is hydrophilic.
Be below experiment in vitro, the concrete mode of its experiment is as follows:
Experiment in vitro: transparent, internal diameter is 0.8 millimeter, the pvc pipe flexing being about 3 meters becomes S vascular pattern, and whole simulation pipeline is full of the water that pressure is 40-50mmHg, and the flowing of water maintains this pressure by force (forcing) pump supplementing water.
This micro-wire sent into by short sheath via band haemostatic valve, pushes and rotates micro-wire, observe and feel know from experience propelling movement forward, post-tensioning and the situation in crooked pipeline part.Contrast stainless steel silk, the operational circumstances of Ultimum Ti micro-wire in this model.
Animal experiment in vivo: through femoral arteriography, is seated in femoral artery by short for band haemostatic valve sheath, and novel micro-wire sent into by the short sheath of band haemostatic valve, and examination volume can in endovascular propelling movement, post-tensioning and the situation importing curved blood vessel.Relatively stainless steel silk, the operational circumstances of Ultimum Ti micro-wire in this animal blood vessels.
The foregoing is only the preferred embodiment of the present invention; not thereby the scope of the claims of the present invention is limited; every utilize description of the present invention and accompanying drawing content to do equivalent structure or equivalent flow process conversion; or be directly or indirectly used in other relevant technical field, be all in like manner included in scope of patent protection of the present invention.
Claims (6)
1. Wicresoft gets involved and uses a hydrophilic micro-wire, it is characterized in that: this hydrophilic micro-wire comprises: Ultimum Ti wire rod plug (1), tungsten filament spring (2), waterborne polymeric external coating (4); Described Ultimum Ti wire rod plug (1) front end is provided with one section of spring socket part, described spring socket part is tapered, described tungsten filament spring (2) is placed on spring socket part, and the rear and front end of tungsten filament spring (2) is fixed on spring socket part by laser weld; After described tungsten filament spring (2) is placed on spring socket part, there is one deck waterborne polymeric external coating (4) at Ultimum Ti wire rod plug (1) and tungsten filament spring (2) outer cover; Described waterborne polymeric external coating (4) surface scribbles one deck hydrophilic coating.
2. a kind of Wicresoft according to claim 1 gets involved and uses hydrophilic micro-wire, it is characterized in that: described waterborne polymeric external coating (4) comprises polyurethane clad, nylon bag coating, block polyetheramides elastomer clad.
3. a kind of Wicresoft according to claim 1 gets involved and uses hydrophilic micro-wire, it is characterized in that: described hydrophilic coating comprises PVP hydrophilic coating, maleic acid hydrophilic coating.
4. a kind of Wicresoft according to claim 1 gets involved and uses hydrophilic micro-wire, it is characterized in that: the diameter of described Ultimum Ti wire rod plug (1) is 0.5mm, its entire length is 150cm, the length of the volute spring socket part of Ultimum Ti wire rod plug (1) front end is 30cm, and the end diameter of described spring socket part is 0.15mm.
5. a kind of Wicresoft according to claim 1 gets involved and uses hydrophilic micro-wire, it is characterized in that: the wire diameter of described tungsten filament spring (2) is between 0.03 ~ 0.05mm, the internal diameter of tungsten filament spring (2) is 0.3mm, and the length of described tungsten filament spring (2) is less than spring socket part 3cm.
6. get involved with hydrophilic micro-wire and preparation method thereof with Wicresoft according to claim 1 for one kind, it is characterized in that, this manufacture method comprises the following steps:
1), material prepares:
Length is 1, the Ultimum Ti wire rod of 150cm, external diameter 0.5mm;
Diameter is 1, tungsten filament between 0.03 ~ 0.05mm;
2) be, by length 150cm, Ultimum Ti wire rod one end of external diameter 0.5mm sends between the Grinding wheel of coreless grinding machine and guide wheel, be ground to the tapering gradually thin segment of front end 30cm, the external diameter foremost of this gradually thin segment is 0.15mm;
3), by the tungsten filament of diameter between 0.03 ~ 0.05mm at external diameter be 0.3mm plug on turn to tungsten filament spring;
4), get above-mentioned steps 3) in tungsten filament spring (2) length 12cm, be inserted in from the levigate end of Ultimum Ti wire rod, tungsten filament spring (2) front and back end laser weld is fixed;
5), the above-mentioned Ultimum Ti wire rod being wound with tungsten filament spring through being equipped with " T " coating mould, and the rear that the coated external diameter of mouth mould is " T " coating mould of the tube extruding machine of 0.8mm is sent into mouth and is sent into, and makes coated one layer of polymeric outside it;
6), with commercial medical polymer hydrophilic coating in above-mentioned steps 5) product on coating one thin hydrophilic coating.
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| CN201510759045.1A CN105268085A (en) | 2015-11-10 | 2015-11-10 | Hydrophilic micro-guide wire for minimally-invasive intervention and manufacturing method of hydrophilic micro-guide wire |
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| CN201510759045.1A CN105268085A (en) | 2015-11-10 | 2015-11-10 | Hydrophilic micro-guide wire for minimally-invasive intervention and manufacturing method of hydrophilic micro-guide wire |
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| CN106955411A (en) * | 2017-04-10 | 2017-07-18 | 深圳麦普奇医疗科技有限公司 | A kind of new uropoiesis and digestive endoscope zebra superslide seal wire |
| CN107510864A (en) * | 2017-04-10 | 2017-12-26 | 深圳麦普奇医疗科技有限公司 | A kind of anti-slip interventional medicine hydrophilic seal wire and preparation method thereof |
| CN107929819A (en) * | 2017-11-23 | 2018-04-20 | 湘潭大学 | A kind of medical metal surface hydrophilic coating and preparation method thereof |
| CN108042176A (en) * | 2018-01-11 | 2018-05-18 | 恩脉（上海）医疗科技有限公司 | Take pin device |
| CN110339460A (en) * | 2019-07-17 | 2019-10-18 | 深圳市凯思特医疗科技股份有限公司 | A kind of production method of loach seal wire |
| CN110681031A (en) * | 2019-11-11 | 2020-01-14 | 湖南埃普特医疗器械有限公司 | Contrast guide wire and preparation method thereof |
| CN111012998A (en) * | 2020-02-25 | 2020-04-17 | 深圳麦普奇医疗科技有限公司 | Interventional therapy medical micro-guide wire and manufacturing method thereof |
| CN113769239A (en) * | 2021-10-12 | 2021-12-10 | 湖南省顺美医疗科技有限公司 | Method for manufacturing medical guide wire |
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| CN106955411A (en) * | 2017-04-10 | 2017-07-18 | 深圳麦普奇医疗科技有限公司 | A kind of new uropoiesis and digestive endoscope zebra superslide seal wire |
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| CN107929819A (en) * | 2017-11-23 | 2018-04-20 | 湘潭大学 | A kind of medical metal surface hydrophilic coating and preparation method thereof |
| CN107929819B (en) * | 2017-11-23 | 2020-07-03 | 湘潭大学 | Medical metal surface hydrophilic coating and preparation method thereof |
| CN108042176A (en) * | 2018-01-11 | 2018-05-18 | 恩脉（上海）医疗科技有限公司 | Take pin device |
| CN110339460A (en) * | 2019-07-17 | 2019-10-18 | 深圳市凯思特医疗科技股份有限公司 | A kind of production method of loach seal wire |
| CN110339460B (en) * | 2019-07-17 | 2022-04-01 | 深圳市凯思特医疗科技股份有限公司 | Manufacturing method of loach guide wire |
| CN110681031A (en) * | 2019-11-11 | 2020-01-14 | 湖南埃普特医疗器械有限公司 | Contrast guide wire and preparation method thereof |
| CN111012998A (en) * | 2020-02-25 | 2020-04-17 | 深圳麦普奇医疗科技有限公司 | Interventional therapy medical micro-guide wire and manufacturing method thereof |
| CN113769239A (en) * | 2021-10-12 | 2021-12-10 | 湖南省顺美医疗科技有限公司 | Method for manufacturing medical guide wire |
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Application publication date: 20160127 |