CN105268084A - Guide wire applicable to clinical intravascular interventional therapy and manufacturing method of guide wire - Google Patents
Guide wire applicable to clinical intravascular interventional therapy and manufacturing method of guide wire Download PDFInfo
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- CN105268084A CN105268084A CN201510758937.XA CN201510758937A CN105268084A CN 105268084 A CN105268084 A CN 105268084A CN 201510758937 A CN201510758937 A CN 201510758937A CN 105268084 A CN105268084 A CN 105268084A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09058—Basic structures of guide wires
- A61M2025/09083—Basic structures of guide wires having a coil around a core
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09108—Methods for making a guide wire
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09133—Guide wires having specific material compositions or coatings; Materials with specific mechanical behaviours, e.g. stiffness, strength to transmit torque
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
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- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
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- Pulmonology (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a novel guide wire applicable to clinical intravascular interventional therapy and a manufacturing method of the guide wire. The guide wire comprises a nickel-titanium memory alloy wire core rod, a tungsten-wire spring and a polymer outer coating layer, wherein a conical spring sleeving part is disposed at the front end of the nickel-titanium memory alloy wire core rod, the tungsten-wire spring sleeves the spring sleeving part, and the front end and the rear end of the tungsten-wire spring are fixed on the spring sleeving part through PU glue; the polymer outer coating layer sleeves the nickel-titanium memory alloy wire core rod and the tungsten-wire spring after the tungsten-wire spring sleeves the spring sleeving part; a hydrophilic coating coats the surface of the polymer outer coating layer. The novel guide wire applicable to the clinical intravascular interventional therapy has the excellent pushing performance of a spring guide wire, has extremely good X-ray traceability, and has the advantages of small vascular irritation, good blood and biological compatibility and easiness in blood vessel passing of a polymer super-smooth guide wire.
Description
Technical field
The present invention relates to medical apparatus and instruments, relate to a kind of interventional therapy guiding wire be applied in clinical vascular and preparation method thereof specifically.
Background technology
Minimally-invasive vascular intervenien therapy technology is as emerging Advances in Medicine, progressively promoted at home in recent years, its process is under the guiding of medical imaging device, interventional medical device is sent to a lot of vitals of human body and position through naturally occurring blood vessel access by selectivity, as: heart, liver, brain, kidney, digestive system and reproductive system, thus carry out important technology and the method for Diagnosis and Treat, there is advantage that is little without the need to surgical operation, wound, medical expense relative moderate.In intervene operation, guiding wire plays catheter directed target site, the guiding function opening inaccessible tube chamber.
But current clinical conventional seal wire has two large classes: i.e. spring-guide wire and polymer overmold memorial alloy seal wire.It is good that spring-guide wire pushes performance in operation, but due to the effect of surperficial turn, easily stimulate vasospasm and injured blood vessel wall, is also easy to cause seal wire surface thrombosis; Superslide memorial alloy seal wire then forms water-wetted surface due to polymer overmold, have to blood vessel wall stimulate minimum, not easily injured blood vessel wall, be easy to the advantage of passing through in blood, but push performance obviously not as spring-guide wire.
Comparatively ideal guiding wire should possess not only push performance good, and to blood vessel wall stimulate little, without thrombosis, by features such as property are good in blood vessel or other body cavitys.From material, the stainless steel silk that spring-guide wire adopts is easy to bend or distortion under external force, usually causes the failure of further interventional procedure.
Therefore, need to provide a kind of close method to make interventional therapy guiding wire, the Novel interventional therapy guiding wire adopting new method to make, will can be that clinical intervention medical treatment provides novel, safety, performance better interventional medicine seal wire equipment.
Summary of the invention
For deficiency of the prior art, the technical problem to be solved in the present invention there are provided a kind of interventional therapy guiding wire be applied in clinical vascular and preparation method thereof.
For solving the problems of the technologies described above, the present invention is realized by following scheme:
Be applied to the Novel interventional therapy guiding wire in clinical vascular, this guiding wire comprises: Ultimum Ti wire rod plug, tungsten filament spring, polymer external coating; Described Ultimum Ti wire core nose is provided with one section of spring socket part, and described spring socket part is tapered, and described tungsten filament spring is placed on spring housing and connects in portion, and the rear and front end of tungsten filament spring is fixed on spring socket part by PU glue; Described tungsten filament spring is placed on after spring housing meets portion, has one layer of polymeric external coating at Ultimum Ti wire rod plug and tungsten filament spring outer cover; Described polymer external coating surface scribbles one deck hydrophilic coating.
Further, described polymer external coating comprises polyurethane clad, nylon bag coating, block polyetheramides elastomer clad.
Further, described hydrophilic coating comprises PVP hydrophilic coating, maleic acid hydrophilic coating.
Further, the diameter of described Ultimum Ti wire rod plug is 0.5mm, and its entire length is 150cm, and the length of the volute spring socket part of Ultimum Ti wire core nose is 15cm, and the end diameter of described spring socket part is 0.15mm.
Further, the wire diameter of described tungsten filament spring is between 0.03 ~ 0.05mm, and the internal diameter of tungsten filament spring is 0.3mm.
Be applied to a manufacture method for the Novel interventional therapy guiding wire in clinical vascular, manufacture method comprises the following steps:
1), material prepares:
Length is 1, the Ultimum Ti wire rod of 150cm, external diameter 0.5mm;
Diameter is 1, tungsten filament between 0.03 ~ 0.05mm;
2) be, by length 150cm, Ultimum Ti wire rod one end of external diameter 0.5mm sends between the Grinding wheel of coreless grinding machine and guide wheel, be ground to the tapering gradually thin segment of front end 15cm, the external diameter foremost of this gradually thin segment is 0.15mm;
3), by the tungsten filament of diameter between 0.03 ~ 0.05mm at external diameter be 0.3mm plug on turn to tungsten filament spring;
4), get above-mentioned steps 3) in tungsten filament its length 12cm, be inserted in from the levigate end of Ultimum Ti wire rod, tungsten filament spring front and back end PU glue is fixed;
5), the above-mentioned Ultimum Ti wire rod being wound with tungsten filament spring through being equipped with " T " coating mould, and the rear that the coated external diameter of mouth mould is " T " coating mould of the tube extruding machine of 0.8mm is sent into mouth and is sent into, and makes coated one layer of polymeric outside it;
6), with commercial medical polymer hydrophilic coating in above-mentioned steps 5) product on coating one thin hydrophilic coating.
The present invention adopts Ultimum Ti wire rod to be about the long tapering gradually thin segment of 15cm through being ground to front end, after the bend fixing of front end, be 15cm by length, internal diameter is greater than the tungsten filament spring housing that can be inserted in smoothly in this seal wire tapering gradually full section of thin segment, make the NiTi wire rod front end that just tapering is gradually thin originally become the seal wire front end that cover has Tungsten coil.Then adopt wire cladding technology, have the seal wire front end of tungsten filament spring and full section coated polymer at this cover, as polyurethane or nylon, Pebax etc., become the seal wire that full section is wrapped by.Then PVP, maleic acid or other hydrophilic high mols can be cross-linked and form hydrophilic coating at polymer surfaces by the later stage.
The present invention adopts memorial alloy seal wire wire rod, tungsten filament, polymeric material to form seal wire.Its construction features are, memory alloy wire is in conjunction with tungsten filament spring as seal wire plug, and in this plug, memorial alloy super-elasticity and memory performance are in conjunction with the tungsten filament spring on the levigate end of tapering, and propelling movement and handling are significantly promoted; The polymer then Wheat straw mulching metal wire rod that this mandrel outer is coated, makes it greatly reduce the probability of the stimulation of blood vessel and injured blood vessel inwall.Another advantage of polymer outer cladding is very easily in coated hydrophilic high molecular material, and its hydrophilic and blood compatibility is obviously improved, and interventional procedure is also easy to carry out because seal wire is hydrophilic.
Relative to prior art, the invention has the beneficial effects as follows: the present invention introduces and is a kind ofly applied to clinical Novel interventional therapy guiding wire.This seal wire not only has the propelling movement performance of spring-guide wire excellence, also has fabulous x-ray traceability, also has, the blood minimum to blood vessel irritation of polymer superslide seal wire and good biocompatibility, advantage easily through blood vessel access.Ultimum Ti silk then can not bend and distortion because material has super-elasticity and memory performance under the external power of operation.From structure, spring application on spring-guide wire, the front end having made seal wire plug tapering levigate not only pushes intensity enhancing, also more impart better handling, this is obviously better than the levigate front end of Ultimum Ti seal wire tapering only coated polymer and the situation causing handling to decline.And Ultimum Ti seal wire adopts polymer overmold to make seal wire and vessel wall contact face not be scleroid hard metal but limber polymer, reduce and avoid vascular wall damage and the stimulation to blood vessel.Ultimum Ti composition polymer is coated is also beneficial to the attachment of hydrophilic high mol material, and the hydrophilic coating on its surface significantly improves the blood compatibility of seal wire, reduces thrombosis and is beneficial to and pass through in blood and body cavity body fluid.Ultimum Ti seal wire in material because its excellent super-elasticity and memory performance are better than stainless steel spring seal wire; Structurally, the gradually thin front end sleeve of tapering, with turn spline structure, makes seal wire obviously exceed only with the NiTi superslide seal wire of polymer overmold front end in propelling movement performance and override capability.On seal wire surface, the polymer on Ultimum Ti seal wire surface is easy to apply water wetted material, thus reaches the effect that surperficial superslide blood and biocompatibility significantly promote.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is that Ultimum Ti wire rod front end of the present invention is ground to tapering gradually thin step schematic diagram.
Fig. 2 is Tungsten coil coiling step schematic diagram of the present invention.
Fig. 3 be the present invention the grinding of NiTi wire rod gradually taper end be inserted in and fix tungsten filament spring schematic diagram.
Fig. 4 is that cover of the present invention has the Ultimum Ti plug of Tungsten coil to be wrapped by one layer of polymeric.
Labelling in accompanying drawing: Ultimum Ti wire rod plug 1, tungsten filament spring 2, plug 3, polymer external coating 4.
Detailed description of the invention
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are described in detail, can be easier to make advantages and features of the invention be readily appreciated by one skilled in the art, thus more explicit defining is made to protection scope of the present invention.
Please refer to accompanying drawing 1 ~ 4, a kind of Novel interventional therapy guiding wire be applied in clinical vascular of the present invention, this guiding wire comprises: Ultimum Ti wire rod plug 1, tungsten filament spring 2, polymer external coating 4; Described Ultimum Ti wire rod plug 1 front end is provided with one section of spring socket part, and described spring socket part is tapered, and described tungsten filament spring 2 is placed on spring socket part, and the rear and front end of tungsten filament spring 2 is fixed on spring socket part by PU glue; After described tungsten filament spring 2 is placed on spring socket part, there is one layer of polymeric external coating 4 at Ultimum Ti wire rod plug 1 and tungsten filament spring 2 outer cover; Described polymer external coating 4 surface scribbles one deck hydrophilic coating.Described polymer external coating 4 comprises polyurethane clad, nylon bag coating, block polyetheramides elastomer clad.Described hydrophilic coating comprises PVP hydrophilic coating, maleic acid hydrophilic coating, the diameter of described Ultimum Ti wire rod plug 1 is 0.5mm, its entire length is 150cm, the length of the volute spring socket part of Ultimum Ti wire rod plug 1 front end is 15cm, the end diameter of described spring socket part is 0.15mm, the wire diameter of described tungsten filament spring 2 is between 0.03 ~ 0.05mm, and the internal diameter of tungsten filament spring 2 is 0.3mm.
The present invention is applied to the manufacture method of the Novel interventional therapy guiding wire in clinical vascular, and this manufacture method comprises the following steps:
1, material prepares:
Length is 1, the Ultimum Ti wire rod of 150cm, external diameter 0.5mm;
Diameter is 1, tungsten filament between 0.03 ~ 0.05mm;
2, be 150cm by length, Ultimum Ti wire rod one end of external diameter 0.5mm sends between the Grinding wheel of coreless grinding machine and guide wheel, is ground to the tapering gradually thin segment of front end 15cm, and the external diameter foremost of this gradually thin segment is 0.15mm;
3, by the tungsten filament of diameter between 0.03 ~ 0.05mm at external diameter be 0.3mm plug 3 on turn to tungsten filament spring;
4, get the tungsten filament spring 2 length 12cm in above-mentioned steps 3, be inserted in from the levigate end of Ultimum Ti wire rod, tungsten filament spring 2 front and back end PU glue is fixed;
5, the above-mentioned Ultimum Ti wire rod being wound with tungsten filament spring is through being equipped with " T " coating mould, and the rear that the coated external diameter of mouth mould is " T " coating mould of the tube extruding machine of 0.8mm is sent into mouth and sent into, and makes coated one layer of polymeric outside it;
6, on the product of above-mentioned steps 5, a thin hydrophilic coating is applied with commercial medical polymer hydrophilic coating.
Be below traditional spring-guide wire, NiTi superslide seal wire and novel seal wire of the present invention contrast chart:
| Spring-guide wire | NiTi superslide seal wire | Novel seal wire | |
| Propelling movement property | Excellent | Poor | Excellent |
| Handling | Good | Better | Fabulous |
| Blood vessel wall is stimulated | Greatly | Minimum | Minimum |
| Cause thrombosis possibility | Greatly | Minimum | Minimum |
| Vasospasm occurs | More | Seldom | Seldom |
| Vascular damaged | More | Nothing | Nothing |
| In blood and the body intraluminal fluid property passed through | Generally | Fabulous | Fabulous |
| Whether easily torsional deformation | Easily | Can not | Can not |
| Biocompatibility | Difference | Good | Good |
From above relatively, Ultimum Ti seal wire in material because its excellent super-elasticity and memory performance are better than stainless steel spring seal wire; Structurally, the gradually thin front end sleeve of tapering, with turn spline structure, makes seal wire obviously exceed only with the NiTi superslide seal wire of polymer overmold front end in propelling movement performance and override capability.On seal wire surface, the polymer on Ultimum Ti seal wire surface is easy to apply water wetted material, thus reaches the effect that surperficial superslide blood and biocompatibility significantly promote.Advantage on comprehensive two class wire configurations, the Novel interventional therapy guiding wire adopting new method to make, will can be that clinical intervention medical treatment provides novel, safety, performance better interventional medicine seal wire equipment.
The present invention adopts Ultimum Ti wire rod through being ground to the about 15 centimeters of long taperings in front end gradually thin segment, after the bend fixing of front end, be 15 centimeters by length, internal diameter is greater than the tungsten filament spring housing that can be inserted in smoothly in this seal wire tapering gradually full section of thin segment, make the NiTi wire rod front end that just tapering is gradually thin originally become the seal wire front end that cover has Tungsten coil.
Then adopt wire cladding technology, have the seal wire front end of Tungsten coil and full section coated polymer at this cover, as polyurethane or nylon, Pebax etc., become the seal wire that full section is wrapped by.Then PVP, maleic acid or other hydrophilic high mols can be cross-linked and form surface hydrophilic coating at polymer surfaces by the later stage.
The present invention adopts memorial alloy seal wire wire rod, tungsten filament, polymeric material to form seal wire.Its construction features are, memory alloy wire is in conjunction with tungsten filament spring as seal wire plug, and in this plug, memorial alloy super-elasticity and memory performance are in conjunction with the tungsten filament spring on the levigate end of tapering, and propelling movement and handling are significantly promoted; The polymer then Wheat straw mulching metal wire rod that this mandrel outer is coated, makes it greatly reduce the probability of the stimulation of blood vessel and injured blood vessel inwall.Another advantage of polymer outer cladding is very easily in coated hydrophilic high molecular material, and its hydrophilic and blood compatibility is obviously improved, and interventional procedure is also easy to carry out because seal wire is hydrophilic.
Be below experiment in vitro, the concrete mode of its experiment is as follows:
Experiment in vitro: transparent, internal diameter is 1.5 millimeters, the pvc pipe flexing being about 3 meters becomes S vascular pattern, and whole simulation pipeline is full of the water that pressure is 40-50mmHg, and the flowing of water maintains this pressure by force (forcing) pump supplementing water.
This seal wire sent into by short sheath via band haemostatic valve, pushes and rotates seal wire, observe and feel know from experience propelling movement forward, post-tensioning and the situation in crooked pipeline part.Contrast stainless steel silk, the operational circumstances of Ultimum Ti seal wire in this model.
Animal experiment in vivo: through femoral arteriography, is seated in femoral artery by short for band haemostatic valve sheath, and novel seal wire sent into by the short sheath of band haemostatic valve, and examination volume can in endovascular propelling movement, post-tensioning and the situation importing curved blood vessel.Relatively stainless steel silk, the operational circumstances of Ultimum Ti seal wire in this animal blood vessels.
The foregoing is only the preferred embodiment of the present invention; not thereby the scope of the claims of the present invention is limited; every utilize description of the present invention and accompanying drawing content to do equivalent structure or equivalent flow process conversion; or be directly or indirectly used in other relevant technical field, be all in like manner included in scope of patent protection of the present invention.
Claims (6)
1. be applied to the Novel interventional therapy guiding wire in clinical vascular, it is characterized in that: this guiding wire comprises: Ultimum Ti wire rod plug (1), tungsten filament spring (2), polymer external coating (4); Described Ultimum Ti wire rod plug (1) front end is provided with one section of spring socket part, described spring socket part is tapered, described tungsten filament spring (2) is placed on spring socket part, and the rear and front end of tungsten filament spring (2) is fixed on spring socket part by PU glue; After described tungsten filament spring (2) is placed on spring socket part, there is one layer of polymeric external coating (4) at Ultimum Ti wire rod plug (1) and tungsten filament spring (2) outer cover; Described polymer external coating (4) surface scribbles one deck hydrophilic coating.
2. the Novel interventional therapy guiding wire be applied in clinical vascular according to claim 1, is characterized in that: described polymer external coating (4) comprises polyurethane clad, nylon bag coating, block polyetheramides elastomer clad.
3. the Novel interventional therapy guiding wire be applied in clinical vascular according to claim 1, is characterized in that: described hydrophilic coating comprises PVP hydrophilic coating, maleic acid hydrophilic coating.
4. the Novel interventional therapy guiding wire be applied in clinical vascular according to claim 1, it is characterized in that: the diameter of described Ultimum Ti wire rod plug (1) is 0.5mm, its entire length is 150cm, the length of the volute spring socket part of Ultimum Ti wire rod plug (1) front end is 15cm, and the end diameter of described spring socket part is 0.15mm.
5. the Novel interventional therapy guiding wire be applied in clinical vascular according to claim 1, is characterized in that: the wire diameter of described tungsten filament spring (2) is between 0.03 ~ 0.05mm, and the internal diameter of tungsten filament spring (2) is 0.3mm.
6., with a manufacture method for the Novel interventional therapy guiding wire be applied in clinical vascular according to claim 1, it is characterized in that, this manufacture method comprises the following steps:
1), material prepares:
Length is 1, the Ultimum Ti wire rod of 150cm, external diameter 0.5mm;
Diameter is 1, tungsten filament between 0.03 ~ 0.05mm;
2) be, by length 150cm, Ultimum Ti wire rod one end of external diameter 0.5mm sends between the Grinding wheel of coreless grinding machine and guide wheel, be ground to the tapering gradually thin segment of front end 15cm, the external diameter foremost of this gradually thin segment is 0.15mm;
3), by the tungsten filament of diameter between 0.03 ~ 0.05mm at external diameter be 0.3mm plug on turn to tungsten filament spring;
4), get above-mentioned steps 3) in tungsten filament spring (2) length 12cm, be inserted in from the levigate end of Ultimum Ti wire rod, tungsten filament spring (2) front and back end PU glue is fixed;
5), the above-mentioned Ultimum Ti wire rod being wound with tungsten filament spring through being equipped with " T " coating mould, and the rear that the coated external diameter of mouth mould is " T " coating mould of the tube extruding machine of 0.8mm is sent into mouth and is sent into, and makes coated one layer of polymeric outside it;
6), with commercial medical polymer hydrophilic coating in above-mentioned steps 5) product on coating one thin hydrophilic coating.
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| CN201510758937.XA CN105268084A (en) | 2015-11-10 | 2015-11-10 | Guide wire applicable to clinical intravascular interventional therapy and manufacturing method of guide wire |
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| CN201510758937.XA CN105268084A (en) | 2015-11-10 | 2015-11-10 | Guide wire applicable to clinical intravascular interventional therapy and manufacturing method of guide wire |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106859723A (en) * | 2017-04-10 | 2017-06-20 | 深圳麦普奇医疗科技有限公司 | A kind of intravascular intervention medical use degradable in vivo turn |
| CN106902442A (en) * | 2017-05-08 | 2017-06-30 | 心睿珂学（北京）供应链管理发展有限公司 | A kind of labeling method of medical intervention equipment |
| CN107929819A (en) * | 2017-11-23 | 2018-04-20 | 湘潭大学 | A kind of medical metal surface hydrophilic coating and preparation method thereof |
| CN109173012A (en) * | 2018-11-14 | 2019-01-11 | 苏州海维尔医疗器械有限公司 | Anti-scratch superslide seal wire, its method for coating and coating equipment |
| CN110681031A (en) * | 2019-11-11 | 2020-01-14 | 湖南埃普特医疗器械有限公司 | Contrast guide wire and preparation method thereof |
| CN111805108A (en) * | 2019-04-11 | 2020-10-23 | 微创龙脉医疗科技(嘉兴)有限公司 | Medical guide wire and method for welding and forming head end thereof |
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Application publication date: 20160127 |