CN117158429A - Synergistic acaricidal composition - Google Patents

Synergistic acaricidal composition Download PDF

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Publication number
CN117158429A
CN117158429A CN202210588121.7A CN202210588121A CN117158429A CN 117158429 A CN117158429 A CN 117158429A CN 202210588121 A CN202210588121 A CN 202210588121A CN 117158429 A CN117158429 A CN 117158429A
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China
Prior art keywords
compound
etoxazole
synergistic
acaricidal composition
composition according
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CN202210588121.7A
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Chinese (zh)
Inventor
周大伟
郑敬敏
刘欢
赵昱清
乌小瑜
吕兵
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Agricultural Core Crop Technology Co ltd
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Agricultural Core Crop Technology Co ltd
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Priority to CN202210588121.7A priority Critical patent/CN117158429A/en
Priority to PCT/CN2023/086129 priority patent/WO2023226599A1/en
Publication of CN117158429A publication Critical patent/CN117158429A/en
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
    • A01N43/12—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings condensed with a carbocyclic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A01N43/38—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/24—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
    • A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
    • A01N55/04—Tin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P7/00—Arthropodicides
    • A01P7/02—Acaricides

Abstract

The invention belongs to the technical field of pesticides, and particularly relates to a mite-killing composition with a synergistic effect. The effective component of the acaricidal composition comprises an active component A and an active component B, wherein the active component A is preferably a compound shown as the following formula Ia, and the active component B is preferably abamectinAt least one of the substances selected from the group consisting of fenbuconazole, fenbutatin oxide, fenbuconazole nitrile, spirodiclofen and bifenazate. Compared with a single pesticide, the pesticide composition provided by the invention has the advantages that the prevention effect on mites can be effectively improved, the synergistic effect is obvious, the use amount can be effectively reduced, the use cost is reduced, and the influence on the environment is reduced.

Description

Synergistic acaricidal composition
Technical Field
The invention belongs to the technical field of pesticides, and particularly relates to a mite-killing composition with a synergistic effect.
Background
Chinese patent No. 110028431A describes a trifluoroethyl thioether (sulfoxide) substituted benzene compound and its mite-killing application, and has obvious effect of preventing and controlling mites, and its general formula is:
i
In the above formula 1, R 1 、 R 2 Each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl, or C1-C4 haloalkyl;
n is selected from 0 or 1;
R 3 、R 4 、R 5 、R 6 each independently selected from hydrogen, halogen, cyano, nitro, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, or C1-C4 haloalkoxy.
In specific agricultural practices, acaricides containing a single active ingredient, if used singly for many years, tend to cause different degrees of resistance to mites. Aiming at the problem, a person skilled in the art usually compounds the two active ingredients, and screens out a composition with a synergistic effect and a weight ratio through a specific test, so that the control effect can be effectively improved, the dosage of a medicament is reduced, the use cost is reduced, and the generation of drug resistance of mites can be delayed. However, three different results, namely antagonism, addition or synergy, may occur after the two active ingredients are compounded, and whether the synergy can be generated is unpredictable and needs to be known through specific experiments.
The applicant has found through specific experimental study that in the formula I, R is as follows 1 Is F, R 2 Is Me, R 3 Is H, R 4 Is H, R 5 Is H, R 6 When H and n are 1, namely, the compound No. 2 disclosed in patent document CN110028431a (hereinafter referred to as SA 2002), the acaricidal activity is excellent, and the synergistic effect is remarkable after the compound and other conventional acaricidal compounds are compounded in a specific ratio. The structural formula of the specific compound is shown in the following formula Ia:
ia (Ia)
In the prior art, the compound with the structural formula Ia is compounded with other compounds, and the situation is not reported.
Disclosure of Invention
The invention aims to provide a mite-killing composition with synergistic active ingredients, which can meet the requirements of improving the control effect and delaying the generation of drug resistance in the field of controlling pests and mites in agriculture. And under the national advocated pesticide reduction and synergy policy, the pesticide can replace high-toxicity or environment-friendly pesticide.
In order to achieve the above purpose, the invention adopts the following technical scheme:
a synergistic acaricidal composition comprising: (a) at least one compound of formula i:
i
In the above formula 1, R 1 、R 2 Each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl, or C1-C4 haloalkyl;
n is selected from 0 or 1;
R 3 、R 4 、R 5 、R 6 each independently selected from hydrogen, halogen, cyano, nitro, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, or C1-C4 haloalkoxy.
And at least one further active compound (B) selected from:
(1) Glutamate-gated chloride channel allosteric modulators: abamectin, emamectin benzoate and milbemycin;
(2) Mite growth inhibitor: clofentezine, flufenzine, hexythiazox, etoxazole;
(3) Mitochondrial ATP synthase inhibitors: azocyclotin, tricyclotin, fenbutatin oxide, clofentezine, diafenthiuron;
(4) Complex ii electron transfer inhibitors: cyenopyrafen, etoxazole and cyflumetofen;
(5) Complex iii electron transfer inhibitors: bifenazate, chloranil, and pyriminostrobin;
(6) Acetyl-coa carboxylase inhibitors: spirodiclofen, spiromesifen and spirotetramat;
(7) Complex I electron transfer inhibitors: fenazaquin, fenpyroximate, pyriminostrobin, pyridaben, tebufenpyrad, tolfenpyrad, rotenone;
(8) Sodium ion channel modulators: bifenthrin, cyhalothrin, cypermethrin, deltamethrin, ethofenprox, fenpropathrin;
(9) Octopamine receptor agonists: amitraz;
(10) Other mechanisms of action are: azadirachtin, mineral oil, vegetable oil, fenisobromolate, fluazinam;
(11) Gamma-aminobutyric acid gated chloride ion channel allosteric modulators: isoxazole acetamiprid
Further, the method comprises the steps of,
the compound (a) in the synergistic acaricidal composition of the present invention is preferably a compound of the following formula Ia:
ia (Ia)
The weight ratio of the compound (A) to the compound (B) is 50:1 to 1:50, preferably 20:1 to 1:20, more preferably 10:1 to 1:10.
Particularly, when the compound (A) in the synergistic acaricidal composition is the compound shown in the formula Ia, and the compound (B) is abamectin, the weight ratio of the compound (A) to the abamectin is most preferably 10:1-2:1;
when the compound (A) in the synergistic acaricidal composition is the compound shown in the formula Ia, the compound (B) is bifenazate, spirodiclofen or benzene Ding Xishi, and the weight ratio of the two is most preferably 1:1-1:5;
when the compound (A) in the synergistic acaricidal composition is the compound shown in the formula Ia, and the compound (B) is etoxazole or etoxazole, the weight ratio of the two is most preferably 2:1-1:2;
the acaricide for controlling mites is characterized by comprising the active ingredient in a high-purity form (solid active matter with specific purity) and at least one of adjuvants which are conventional in the pesticide processing field and comprise a surfactant, an antifreezing agent, an antifoaming agent, a thickening agent, a preservative, an acid-base regulator and deionized water.
The surfactants mentioned are, depending on the type of formulation of the active ingredient to be formulated, suitable surfactants are anionic, cationic, nonionic surfactants or surfactant mixtures which have good emulsifying, dispersing, wetting, spreading, penetrating, synergistic properties, are ingredients which are usual or permissible in the field of pesticide formulation processing, and are not particularly limited, the specific ingredients and amounts being determined experimentally according to the formulation requirements.
Examples of such anionic surfactants are water-soluble synthetic anionic and water-soluble soap anionic surfactants. Synthetic anionic surfactants are particularly indicated as fatty sulphonates, fatty sulphates, alkylaryl sulphonates. Fatty sulfonates and fatty sulfates are generally present in the form of alkali metal salts, alkaline earth metal salts, (substituted or unsubstituted) triethanolamine salts, which are generally alkyl groups containing from about 8 to 22 carbon atoms, where alkyl is also understood to include the alkyl portion of acyl groups, such as sodium/calcium lignosulfonate, lauryl sulfate or sodium lauryl sulfate, and also the sulfate or sulfonate salts of fatty alcohol/ethylene oxide adducts. Examples of alkylaryl sulfonates are the sodium, calcium, triethanolamine salts of dibutylnaphthalene sulfonic acid or naphthalene sulfonic acid/formaldehyde condensates, (substituted or unsubstituted), and also possible phosphates, such as the phosphate or sulfate salts of alkylaryl (4-14) ethylene oxide adducts; the water-soluble soap anionic surfactants are generally alkali metal, alkaline earth metal or ammonium salts of fatty acids having from about 10 to 22 carbon atoms, such as sodium or potassium salts of oleic or stearic acid, and also sodium or potassium salts of natural fatty acid mixtures obtained from natural oils, with particular emphasis being given here to the fatty acid methyl taurates.
The cationic surfactant comprises amine salt cations and quaternary ammonium salt cations. Ammonium salt cations are typically ammonium salts formed by neutralization of higher primary, secondary and tertiary amines with acids, the carbon atoms of the hydrophobe moiety typically being between 10 and 18, and the acids used to neutralize the fatty amines being hydrochloric acid, formic acid, acetic acid, sulfuric acid. The quaternary ammonium salt cation is a quaternary ammonium salt having, as a substituent, generally an alkyl group having at least one carbon atom of 8 to 22, a lower alkyl group or a hydroxyalkyl group or a benzyl group.
The nonionic surfactant is particularly a polyethylene glycol ether derivative of an aliphatic or cycloaliphatic alcohol, a saturated or unsaturated fatty acid or an alkylphenol, the aliphatic or cycloaliphatic alcohol having 8 to 16 carbon atoms in the moiety or 6 to 18 carbon atoms in the alkyl moiety of the alkylphenol, and the polyethylene glycol ether derivative having 3 to 30 glycol ether groups. Still another class is the adducts of polyethylene oxide with polypropylene glycol or alkyl polypropylene glycol, ethylene diamine polypropylene glycol, generally having an alkyl moiety of about 1 to 10 carbon atoms, 10 to 250 glycol ether units, 10 to 100 propylene glycol ether units, and examples which may be mentioned are castor oil polyethylene glycol ether, polyethylene oxide/polypropylene oxide, tributylphenoxy polyethylene glycol, polyoxyethylene sorbitan trioleate.
The antifreezing agent is various antifreezing agents well known in the pesticide preparation field, and can be one or more of ethylene glycol, propylene glycol, glycerol, diethylene glycol, urea and inorganic salts.
The defoamer is various defoamers known in the pesticide preparation field, and can be one or more of silicone compounds, epoxidized soybean oil, emulsified silicone oil and fatty alcohol.
The thickener is various thickeners known in the pesticide preparation field, and can be one or more of xanthan gum, polyvinyl alcohol, sodium alginate, gum arabic, magnesium aluminum silicate and white carbon black.
The preservative is various preservatives known in the pesticide preparation field, and the preservative can be one or more of kathon, sodium benzoate, benzoic acid, potassium sorbate and formaldehyde.
The acid-base regulator is various acidic, alkaline and buffer solutions well known in the pesticide preparation field. Specific examples of acids are hydrochloric acid, sulfuric acid, acetic acid, phosphoric acid, citric acid, tartaric acid, maleic acid, acidic amino acids, malic acid, potassium dihydrogen sulfate, ammonium sulfate; specific examples of the alkali include sodium hydroxide, potassium hydroxide, aqueous ammonia solution, ethylenediamine, ethanolamine, dipotassium hydrogen phosphate, and basic amino acid; examples of buffer solutions are phosphate buffer solutions, borate buffer solutions, and boric acid buffer solutions.
The deionized water is industrial deionized water.
Typically, these compositions comprise from 0.1% to 95% of the active ingredient, from 5% to 99.9% of at least one solid or liquid dosage form adjuvant.
Further, the invention provides the application of the synergistic acaricidal composition or acaricide to controlling pest mites. Preferably, the pest mites are spider mites.
The invention achieves the technical effects that:
1. the synergistic acaricidal composition has a synergistic coefficient far higher than 120 and a remarkable synergistic effect compared with a single agent at a ratio of 50:1-1:50;
2. the pesticide usage amount is reduced, and the pesticide usage cost is reduced;
3. the control effect of the medicament on mites is improved;
4. delay the generation of drug resistance of mites and prolong the service life of the drug.
Detailed Description
The combined effect of SA2002 and indoor toxicity of tetranychus cinnabarinus paired with abamectin/bifenazate/etoxazole/spirodiclofen/etoxazole nitrile/benzene Ding Xifu is illustrated by an indoor toxicity determination test, and the indoor toxicity determination method refers to section 13 of pesticide according to the indoor biological determination test criterion of NY/T1154.13-2008 pesticide: leaf disk spray method.
Firstly, preparing the liquid medicine to be tested into mother liquor by using acetone, and then preparing the mother liquor into 5 equal-difference mass concentrations by using tween-80 aqueous solution for later use. Selecting bean leaves with consistent growth, beating into leaf discs by using a puncher, placing a piece of wet sponge in a culture dish, placing filter paper on the leaf discs, placing the leaf discs on the filter paper, 3 leaf discs in each culture dish, inoculating the raised female adult mites onto the leaf discs, and inoculating 20 female adult mites with relatively consistent sizes on each leaf disc. And (3) placing the culture dish on a bottom plate of a potter spray tower for spraying, wherein the spraying amount is 1ml, settling the liquid medicine for 1min, taking out, transferring to a feeding condition for feeding, repeating the treatment for 3 times, additionally setting clear water treatment as a blank control, checking the death condition of tetranychus cinnabarinus 48 hours after the treatment, and calculating the death rate. For the indoor toxicity measurement of mite eggs, a leaf disc spraying method is also referred to, 5 female adult mites are inoculated to each leaf disc for spawning, female adult mites are removed after spawning, the number of mite eggs is checked and calculated in a mirror way, a blank control is additionally arranged every 3 times of treatment, investigation is conducted when the blank control mite eggs are fully hatched, the number of hatched eggs and the number of unhatched eggs are calculated, and the egg hatching rate is calculated.
The test data are statistically processed by DPS software to obtain the correlation coefficient, virulence regression equation, middle lethal concentration and the like, and the grand cloud Peel method is used to obtain the co-virulence coefficient. The combined action of the compound medicament on tetranychus cinnabarinus is evaluated by using the grand cloud peak co-toxicity coefficient, the co-toxicity coefficient >120 is expressed as a synergistic effect, the co-toxicity coefficient is expressed as an additive effect between 80 and 120, the co-toxicity coefficient <80 is expressed as an antagonistic effect, and the results are shown in the following table.
The combined toxicity of the mixed preparation adopts a co-toxicity coefficient method of grand cloud Peel:
TABLE 1 determination of toxicity of the adult mites of the Tetranychus cinnabarinus paired with SA2002 and Avermectin/bifenazate/ethionazole/benzene Ding Xihun
From table 1: SA2002 and abamectin/bifenazate/ethionazole/fenbutatin oxide show a certain synergistic effect on tetranychus cinnabarinus in the weight ratio range of 50:1-1:50, and the synergistic effect is most remarkable when the weight ratio is 20:1-1:20, particularly the weight ratio is 10:1-1:10.
TABLE 2 determination of toxicity of SA2002 and etoxazole/spirodiclofen mixture to cinnabar She Manman eggs
From table 2: SA2002 and etoxazole/spirodiclofen show a certain synergistic effect on tetranychus cinnabarinus eggs within the weight ratio range of 50:1-1:50, and the synergistic effect is most remarkable when the weight ratio is 20:1-1:20, particularly the weight ratio is 10:1-1:10.
The method can be summarized as follows: SA2002 and abamectin/bifenazate/etoxazole/spirodiclofen/etoxazole nitrile/fenbutatin oxide show a certain synergistic effect on tetranychus cinnabarinus within the weight ratio range of 50:1-1:50.
Formulation example 1
SA2002 20%, abamectin 4%, sodium salt of naphthalene sulfonic acid/formaldehyde condensate 3%, tristyryl polyoxyethylene ether phosphate 3%, magnesium aluminum silicate 1.2%, gas-phase white carbon black 1.0%, ethylene glycol 5%, benzoic acid 0.1%, polysiloxane 0.2%, xanthan gum 0.24% and deionized water to 100% by weight. The raw materials are mixed, sheared and dispersed for 30min at high speed, and sand ground by a sand mill until the grain diameter D90 is smaller than 5.0 mu m, and then the 24% SA2002 avermectin suspending agent is prepared according to the formula dosage.
Formulation example 2
SA2002 10%, bifenazate 30%, calcium dodecyl benzene sulfonate 1.5%, polyethylene oxide polypropylene oxide polymer 2.5%, alkylphenol ethoxylate sulfate 2.5%, magnesium aluminum silicate 1.5%, ethylene glycol 5%, benzoic acid 0.1%, polysiloxane 0.22%, xanthan gum 0.2% and deionized water to 100% by weight. The raw materials are mixed, sheared and dispersed for 30min at high speed, and sand ground by a sand mill until the grain diameter D90 is smaller than 5.0 mu m, and then the suspension agent of 40 percent SA2002 biphenyl hydrazine ester is prepared according to the dosage of the formula.
Formulation example 3
SA2002 15%, etoxazole 15%, sodium alkyl polyoxyethylene ether sulfonate 4%, alkylphenol formaldehyde resin polyoxyethylene ether 4%, magnesium aluminum silicate 1.8%, ethylene glycol 5%, benzoic acid 0.1%, polysiloxane 0.2%, xanthan gum 0.25% and deionized water to 100% by weight. The raw materials are mixed, sheared and dispersed for 30min at high speed, and the mixture is sanded by a sand mill until the particle diameter D90 is smaller than 5.0 mu m, and then the mixture is prepared according to the formula dosage, so as to prepare the 30% SA2002/etoxazole suspending agent.
Formulation example 4
SA2002 20%, spirodiclofen 20%, sodium dodecyl sulfate 0.5%, calcium lignosulfonate 2.5%, polyethylene oxide polypropylene oxide polymer 4%, magnesium aluminum silicate 2.0%, ethylene glycol 5%, benzoic acid 0.1%, polysiloxane 0.2%, xanthan gum 0.22% and deionized water to 100% by weight. The raw materials are mixed, sheared and dispersed for 30min at high speed, and the mixture is sanded by a sand mill until the particle diameter D90 is smaller than 5.0 mu m, and then the mixture is prepared according to the formula dosage, so as to prepare the 40% SA2002 spirodiclofen suspending agent.
Formulation example 5
100 weight percent of deionized water is supplemented by SA2002 20 percent, ethaboxam 20 percent, fatty alcohol polyoxyethylene ether 3 percent, calcium lignosulfonate 2 percent, polyvinyl alcohol/polypropylene glycol ether 3 percent, magnesium aluminum silicate 1.5 percent, white carbon black 1.5 percent, propylene glycol 5 percent, kathon 0.02 percent, polysiloxane 0.2 percent and xanthan gum 0.24 percent. The raw materials are mixed, sheared and dispersed for 30min at high speed, and the mixture is sanded by a sand mill until the particle diameter D90 is smaller than 5.0 mu m, and then the mixture is prepared according to the formula dosage, thus obtaining the 40% SA2002. Etoxazole nitrile suspending agent.
Formulation example 6
100 weight percent of deionized water is supplemented by SA2002 10, phenylbutazone 20%, polyethylene oxide polypropylene oxide polymer 1%, aryl phenol polyoxyethylene ether phosphate 4%, monopotassium phosphate 0.2%, magnesium aluminum silicate 0.6%, white carbon black 2.2%, propylene glycol 5%, pinocembrane 0.02%, polysiloxane 0.2%, and xanthan gum. The raw materials are mixed, sheared and dispersed for 30min at high speed, and the mixture is sanded by a sand mill until the particle diameter D90 is smaller than 5.0 mu m, and then the mixture is prepared according to the formula dosage, so as to obtain the 30 percent SA2002-phenyltin suspending agent.
Biological example 1: and (5) field efficacy test for controlling citrus panonychus ulmi.
The applicant carried out field efficacy tests for controlling panonychus citri in 2021 in Guangxi nan ning Wuming district, formulation example 1, formulation example 2, formulation example 3, formulation example 4, formulation example 5, formulation example 6.
The test method comprises the following steps: 2 citrus trees are planted in each cell, each treatment is repeated for 4 times, cell groups are arranged randomly, and water treatment is additionally carried out to form a blank control. The application method adopts a conventional spraying method, and the chemical agent is uniformly sprayed on the front and back surfaces of the citrus branches and leaves, so that the leaves are preferably wet without dripping water. The mite port base number is investigated before the application, 2 citrus trees are investigated per cell by a fixed point investigation method, five points of east, south, west, north and middle are marked per plant, 1 tip is investigated per point, 5 leaves are investigated per tip, 50 leaves are investigated per cell, the number of live mites is recorded, the number of active mites on the leaves is investigated 1 time after the application for 3, 7, 15 and 25 days, the mite port decline rate and the prevention and treatment effect of each treatment are calculated, and the test results are shown in the following table 3.
PTMite mouth reduction rate for the agent treatment area;CKis the mite mouth reduction rate of the blank control area.
Table 3 field control effect of SA2002 compound preparation on panonychus citri
As can be obtained from table 3, the control effect of the formulations of SA2002 and abamectin/bifenazate/etoxazole/spirodiclofen/etoxazole/benzene Ding Xifu on panonychus citri is greatly improved compared with that of single agents, and the effect is obviously better than that of the single agents.
In conclusion, the synergistic acaricidal composition has obvious synergistic effect, can effectively reduce the using amount of pesticides, reduce the using cost, protect the environment and delay the generation of drug resistance of mites compared with a single dose.
It should be noted that the embodiments described herein are illustrative and not exhaustive, and that the scope of the invention is not limited to the embodiments disclosed, but is modified within the scope and spirit of the embodiments described.

Claims (10)

1. A synergistic acaricidal composition comprising:
(A) At least one compound of formula I:
i
In the above formula 1, R 1 、R 2 Each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl, or C1-C4 haloalkyl;
n is selected from 0 or 1;
R 3 、R 4 、R 5 、R 6 each independently selected from hydrogen, halogen, cyano, nitro, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy or C1-C4 haloalkoxy,
and at least one further active compound (B) selected from:
(1) Glutamate-gated chloride channel allosteric modulators: abamectin, emamectin benzoate and milbemycin;
(2) Mite growth inhibitor: clofentezine, flufenzine, hexythiazox, etoxazole;
(3) Mitochondrial ATP synthase inhibitors: azocyclotin, tricyclotin, fenbutatin oxide, clofentezine, diafenthiuron;
(4) Complex ii electron transfer inhibitors: cyenopyrafen, etoxazole and cyflumetofen;
(5) Complex iii electron transfer inhibitors: bifenazate, chloranil, and pyriminostrobin;
(6) Acetyl-coa carboxylase inhibitors: spirodiclofen, spiromesifen and spirotetramat;
(7) Complex I electron transfer inhibitors: fenazaquin, fenpyroximate, pyriminostrobin, pyridaben, tebufenpyrad, tolfenpyrad, rotenone;
(8) Sodium ion channel modulators: bifenthrin, cyhalothrin, cypermethrin, deltamethrin, ethofenprox, fenpropathrin;
(9) Octopamine receptor agonists: amitraz;
(10) Other mechanisms of action are: azadirachtin, mineral oil, vegetable oil, fenisobromolate, fluazinam;
(11) Gamma-aminobutyric acid gated chloride ion channel allosteric modulators: isoxazole tolfenpyrad.
2. Synergistic acaricidal composition according to claim 1, characterized in that the compound of formula (a) is selected from the group of compounds of formula la
Formula Ia.
3. Synergistic acaricidal composition according to claim 1 or 2, characterized in that the further active compound (B) is selected from:
(1) Glutamate-gated chloride channel allosteric modulators: avermectin, emamectin benzoate, milbemycin;
(2) Mite growth inhibitor: clofentezine, flufenzine, hexythiazox, etoxazole;
(3) Mitochondrial ATP synthase inhibitors: azocyclotin, fenbutatin oxide, diafenthiuron;
(4) Complex ii electron transfer inhibitors: cyenopyrafen, etoxazole and cyflumetofen;
(5) Complex iii electron transfer inhibitors: bifenazate and pyriminostrobin;
(6) Acetyl-coa carboxylase inhibitors: spirodiclofen, spiromesifen, spirotetramat.
4. Synergistic acaricidal composition according to claim 1 or 2, characterized in that the further active compound (B) is selected from: avermectin, etoxazole, fenbutatin oxide, etoxazole, spirodiclofen and bifenazate.
5. The synergistic acaricidal composition according to any one of claims 1 to 4, wherein the weight ratio of the compound (a) and the compound (B) is 50:1 to 1:50.
6. The synergistic acaricidal composition according to any one of claims 1 to 4, wherein the weight ratio of the compound (a) and the compound (B) is from 20:1 to 1:20.
7. An acaricide, characterized in that the formulation comprises an acaricidal active ingredient and an adjuvant, the acaricidal active ingredient being the synergistic acaricidal composition according to any one of claims 1 to 4.
8. The acaricide according to claim 7, wherein the acaricide is in the form of: suspending agents, microemulsions, water dispersible granules, solutions, dispersible oil suspensions, ultra-low volume solutions, dispersible solutions, soluble agents, emulsifiable concentrates, aqueous emulsions, microcapsule suspensions, microcapsule suspension-aqueous emulsions, microcapsule suspension-suspensions, microcapsule suspension-emulsions, suspoemulsions, oils, powders, soluble granules, wettable powders.
9. The acaricide according to claim 7, wherein the total mass of the acaricide active ingredient is 1 to 60% of the total mass of the formulation in mass percent.
10. Use of the synergistic acaricidal composition according to any one of claims 1 to 4 for controlling agricultural mites.
CN202210588121.7A 2022-05-27 2022-05-27 Synergistic acaricidal composition Pending CN117158429A (en)

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