CN117129453A - Automatic fluorescence detection equipment - Google Patents
Automatic fluorescence detection equipment Download PDFInfo
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- CN117129453A CN117129453A CN202311018425.0A CN202311018425A CN117129453A CN 117129453 A CN117129453 A CN 117129453A CN 202311018425 A CN202311018425 A CN 202311018425A CN 117129453 A CN117129453 A CN 117129453A
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- 238000001917 fluorescence detection Methods 0.000 title claims abstract description 45
- 238000001514 detection method Methods 0.000 claims abstract description 151
- 238000007789 sealing Methods 0.000 claims abstract description 10
- 239000011521 glass Substances 0.000 claims description 29
- 239000013307 optical fiber Substances 0.000 claims description 9
- 230000003287 optical effect Effects 0.000 claims description 4
- 238000005070 sampling Methods 0.000 abstract description 4
- 239000002699 waste material Substances 0.000 abstract description 2
- 230000007246 mechanism Effects 0.000 description 10
- 238000000034 method Methods 0.000 description 7
- 230000005540 biological transmission Effects 0.000 description 6
- 230000005284 excitation Effects 0.000 description 4
- 239000000835 fiber Substances 0.000 description 3
- 230000003111 delayed effect Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Dispersion Chemistry (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The invention discloses automatic fluorescence detection equipment, which has the technical scheme that: the detection device comprises a detection box, wherein a detection opening is formed in one side of the detection box, a sealing plate is arranged on one side of the detection box, the sealing plate is connected with the detection box through a hinge, a plurality of support pads are fixedly arranged on the bottom surface of the detection box, and a mounting plate is fixedly arranged on the top surface of the inside of the detection box; the adjusting component is arranged in the detection box and used for adjusting the position of a sample, a worker respectively places a plurality of sample slides into slide grooves through arranging the placing blocks, after the fluorescent detection shell detects one sample slide, the rotating motor is started to drive the screw rod to rotate, the connecting block of the placing blocks is enabled to move to one side, the slide groove of the next grid is enabled to move to the lower side of the fluorescent detection shell, so that fluorescent detection can be carried out on the plurality of sample slides, the time for waste of sample feeding and sampling of a single sample slide is reduced, and the fluorescent detection efficiency is improved.
Description
Technical Field
The invention relates to the technical field of fluorescence detection, in particular to automatic fluorescence detection equipment.
Background
In a flow cytometer used in medical and biological fields, a fluorescence detection device is incorporated, and the fluorescence detection device receives fluorescence emitted from a fluorescent dye of a measurement object by irradiation with laser light, thereby identifying the type of the measurement object.
According to the application number: the chinese patent of CN202122887915.7 discloses a fluorescence detection device, which comprises a detection device body, wherein the detection device body is provided with a sample inlet, a support plate for placing a sample is arranged in the detection device body, the position of the support plate corresponds to the position of the sample inlet, and the support plate is in sliding connection with the detection device body. The utility model discloses can realize that the sample gets into the check out test set is originally internal automatically.
There are also disadvantages to a fluorescence detection device, such as: when detecting a plurality of samples, the device can only detect a single sample, and each sample is sent to sample and then the next sample is detected, so that the detection efficiency is greatly delayed.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides automatic fluorescence detection equipment, which solves the problem that when a plurality of samples are detected, the equipment can only detect a single sample, each sample is sent to sample and then the next sample is detected, and the detection efficiency is greatly delayed.
The technical aim of the invention is realized by the following technical scheme:
an automatic fluorescence detection apparatus comprising: the detection device comprises a detection box, wherein a detection opening is formed in one side of the detection box, a sealing plate is arranged on one side of the detection box, the sealing plate is connected with the detection box through a hinge, a plurality of support pads are fixedly arranged on the bottom surface of the detection box, a mounting plate is fixedly arranged on the top surface of the inside of the detection box, and a fluorescent detection shell is fixedly arranged on the bottom surface of the mounting plate; and the adjusting assembly is arranged in the detection box and is used for adjusting the position of the sample.
Through adopting above-mentioned technical scheme, through setting up adjusting part, the closing plate is opened to the staff, places a plurality of detection samples in the detection box after, carries out fluorescence detection to the detection sample through fluorescence detection shell inner structure, after the detection is accomplished, through adjusting part, adjusts the detection sample position to detect subsequent sample, make the detection box can detect a plurality of samples, reduce the step that single detection produced.
Preferably, the adjusting assembly includes: the detection platform, the detection platform sets up the inside at the detection box, the inside movable mounting of detection platform has the piece of placing, a plurality of slide glass groove has been seted up to the top surface of placing the piece, the removal mouth has been seted up to one side of detection platform, one side fixed mounting of detection platform has the fixed plate, one side fixed mounting of fixed plate has the rotating electrical machines, one side fixed mounting of placing the piece has the connecting block, the connecting block passes and removes the mouth and extend to the outside of detection platform, the axle fixedly connected with lead screw of rotating electrical machines, lead screw and connecting block threaded connection are in the same place.
Through adopting above-mentioned technical scheme, through setting up and placing the piece, the staff places a plurality of sample slide glass respectively in the slide glass groove, after fluorescence detection shell detects a sample slide glass, starts the rotating electrical machines, and the rotating electrical machines drives the lead screw and rotates, makes the connecting block of placing the piece remove to one side, makes the slide glass groove of next check remove the below of fluorescence detection shell to can carry out fluorescence detection to a plurality of sample slide glass, reduce single sample slide glass and send a kind extravagant time of sampling, improve fluorescence detection's efficiency.
Preferably, the connecting plates are fixedly arranged on two sides of the detection table, two electric push rods are fixedly arranged on one side of the inside of the detection box, and the electric push rods are fixedly connected with the connecting plates.
Through adopting above-mentioned technical scheme, through setting up electric putter, start electric putter and stretch out, drive the test bench and remove outside the detection box, after the staff placed the sample slide glass in the test bench, start electric putter return stroke, drive the test bench and remove in the detection box, after detecting, start electric putter once more, drive the test bench and remove to need not the staff and carry out the sample feeding sample, improved the degree of automation of device.
Preferably, a guide groove is formed in the inner bottom surface of the detection box, a guide block is fixedly arranged on the bottom surface of the detection table, and the guide block and the guide groove are sleeved together in a sliding mode.
Through adopting above-mentioned technical scheme, through setting up the guide block, when the detection platform at the in-process of detecting box round trip movement, the guide block of detection platform bottom slides in the guide way, prevents the round trip movement in-process, detects the position that the platform removed and appears the deviation, influences subsequent fluorescence detection.
Preferably, the inside of fluorescence detection shell is provided with fiber connection, the inside top surface of fluorescence detection shell is provided with laser emitter, laser emitter is connected with fiber connection, laser emitter's outside is provided with first light filter group, fiber connection's top surface is provided with the second light filter group, the inside top surface fixed mounting of fluorescence detection shell has the dichroscope, inside one side fixed mounting of fluorescence detection shell has the spectrum appearance.
Through adopting above-mentioned technical scheme, through setting up laser emitter, start laser emitter, laser emitter transmission ultraviolet wavelength light constitutes laser transmission mechanism through first light filter group for carry out laser irradiation to the sample slide glass in placing the piece, then constitute fluorescence signal acquisition mechanism through second light filter group, dichroscope, spectrum appearance, the fluorescence signal that produces after the conduction excitation.
Preferably, a limit groove is formed in one side of the inner part of the detection table, a limit block is fixedly arranged on one side of the placement block, and the limit block and the limit groove are sleeved together in a sliding mode.
Through adopting above-mentioned technical scheme, through setting up the stopper, when placing the piece and slide the in-process in the detection platform, through the stopper in the spacing groove, guarantee to place the piece and make a round trip in-process of sliding, can not appear the position offset, lead to the laser that the optical fiber joint in the fluorescence detection shell launched can't shine the slide glass that detects the sample.
Preferably, a plurality of mounting grooves are formed in the inner bottom surface of the detection table, and rollers are rotatably mounted in the mounting grooves.
Through adopting above-mentioned technical scheme, through setting up the gyro wheel, when placing the piece and detecting the platform removal in-process, the gyro wheel of below is passed through to the bottom of placing the piece, reduces the friction of placing the piece and detecting the inside bottom surface of platform, improves and places the piece and slide steadily.
Preferably, the top surface of the placement block is provided with a plurality of grooves.
Through adopting above-mentioned technical scheme, through setting up the recess, when the staff need take out the sample slide in the slide glass groove, through the recess on slide glass groove both sides, make things convenient for the staff to take out the sample slide glass from the slide glass groove.
In summary, the invention has the following advantages:
through setting up and placing the piece, the staff places a plurality of sample slide glass respectively in the slide glass groove, after fluorescence detection shell detects a sample slide glass, starts the rotating electrical machines, and the rotating electrical machines drives the lead screw and rotates, makes the connecting block of placing the piece to one side removal, makes the slide glass groove of next check remove the below of fluorescence detection shell to can carry out fluorescence detection to a plurality of sample slide glass, reduce single sample slide glass and send a sample extravagant time, improve fluorescence detection's efficiency.
Through setting up electric putter, start electric putter and stretch out, drive the test bench and remove outside the detection box, after the staff placed the sample slide glass in the test bench, start electric putter return stroke, drive the test bench and remove in the detection box, after detecting, start electric putter once more, drive the test bench and remove to need not the staff and carry out the sample feeding sample, improved the degree of automation of device.
The laser transmitter is started by arranging the laser transmitter, ultraviolet wavelength light emitted by the laser transmitter forms a laser transmission mechanism through the first optical filter group and is used for carrying out laser irradiation on a sample slide in the placing block, and then a fluorescent signal acquisition mechanism is formed through the second optical filter group, the dichroic mirror and the spectrometer, so that fluorescent signals generated after excitation are conducted.
Drawings
FIG. 1 is a schematic perspective view of the present invention;
FIG. 2 is a schematic cross-sectional view of a cartridge of the present invention;
FIG. 3 is a schematic view of the structure of the inspection station of the present invention;
FIG. 4 is a schematic view of the structure of the connecting block of the present invention;
FIG. 5 is a schematic view of a placement block structure of the present invention;
FIG. 6 is a schematic view of the mounting slot structure of the present invention;
FIG. 7 is a schematic cross-sectional view of a fluorescence detection housing of the present invention.
Reference numerals: 1. a detection box; 2. a detection port; 3. a sealing plate; 4. a support pad; 5. a mounting plate; 6. a fluorescence detection housing; 7. a detection table; 8. placing a block; 9. a slide groove; 10. a groove; 11. a moving port; 12. a rotating electric machine; 13. a fixing plate; 14. a connecting block; 15. a screw rod; 17. a connecting plate; 18. an electric push rod; 19. a guide groove; 20. a guide block; 21. a limiting block; 22. a limit groove; 23. a mounting groove; 24. a roller; 25. a laser emitter; 26. a first filter set; 27. an optical fiber connector; 28. a second filter set; 29. a dichroic mirror; 30. and a spectrometer.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
Referring to fig. 1 and 2, an automatic fluorescence detection apparatus includes: the detection box 1, one side of the detection box 1 is provided with a detection port 2, one side of the detection box 1 is provided with a sealing plate 3, the sealing plate 3 is connected with the detection box 1 through a hinge, the bottom surface of the detection box 1 is fixedly provided with a plurality of support pads 4, the top surface of the inside of the detection box 1 is fixedly provided with a mounting plate 5, and the bottom surface of the mounting plate 5 is fixedly provided with a fluorescent detection shell 6; the adjusting part sets up the inside at detection box 1 for adjust the sample position, through setting up adjusting part, the closing plate 3 is opened to the staff, places a plurality of detection samples in detection box 1 after, carries out fluorescence detection to the detection sample through fluorescence detection shell 6 inner structure, detects the back of accomplishing, through adjusting part, adjusts detection sample position, thereby detects subsequent sample, makes detection box 1 can detect a plurality of samples, reduces the step that single detection produced.
Example two
Based on embodiment 1 described above, referring to fig. 1, 3, 4, 5 and 6, the adjustment assembly includes: the detection platform 7, the detection platform 7 is arranged in the detection box 1, the inside of the detection platform 7 is movably provided with a placement block 8, the top surface of the placement block 8 is provided with a plurality of slide glass grooves 9, one side of the detection platform 7 is provided with a moving opening 11, one side of the detection platform 7 is fixedly provided with a fixed plate 13, one side of the fixed plate 13 is fixedly provided with a rotating motor 12, one side of the placement block 8 is fixedly provided with a connecting block 14, the connecting block 14 passes through the moving opening 11 and extends to the outside of the detection platform 7, the shaft of the rotating motor 12 is fixedly connected with a screw rod 15, the screw rod 15 is connected with the connecting block 14 through threads, by arranging the placement block 8, a worker respectively places a plurality of sample slide glass in the slide glass grooves 9, after the fluorescent detection shell 6 detects one sample slide glass, the rotating motor 12 is started, the rotating motor 12 drives the screw rod 15 to rotate, the connecting block 14 of the placement block 8 moves to one side, the slide glass groove 9 of the next grid is moved to the lower part of the fluorescent detection shell 6, so that fluorescent detection can be carried out on a plurality of sample slide glass, the time wasted by sample feeding and sampling of single sample slide glass is reduced, the fluorescent detection efficiency is improved, a plurality of mounting grooves 23 are formed in the inner bottom surface of the detection table 7, the roller 24 is rotatably arranged in the mounting grooves 23, when the placement block 8 moves in the detection table 7, the friction between the placement block 8 and the inner bottom surface of the detection table 7 is reduced through the roller 24 arranged below, the sliding stability of the placement block 8 is improved, the guide groove 19 is formed in the inner bottom surface of the detection box 1, the guide block 20 is fixedly arranged on the bottom surface of the detection table 7, the guide block 20 is sleeved with the guide groove 19 in a sliding manner, and when the detection table 7 moves back and forth in the detection box 1 through the guide block 20, the guide block 20 at the bottom of the detection table 7 slides in the guide groove 19 to prevent deviation of the moving position of the detection table 7 in the back and forth moving process and influence subsequent fluorescence detection, the top surface of the placement block 8 is provided with a plurality of grooves 10, and when a worker needs to take out a sample slide in the slide groove 9, the worker conveniently takes out the sample slide from the slide groove 9 through the grooves 10 at the two sides of the slide groove 9 by arranging the grooves 10.
Example III
Based on the above embodiment 1 or 2, referring to fig. 1, 2 and 3, the connecting plate 17 is fixedly installed on both sides of the detection platform 7, two electric push rods 18 are fixedly installed on one side of the interior of the detection box 1, the electric push rods 18 are fixedly connected with the connecting plate 17, by setting the electric push rods 18, the electric push rods 18 are started to extend out to drive the detection platform 7 to move out of the detection box 1, after the sample slide is placed into the detection platform 7 by a worker, the electric push rods 18 are started to return, the detection platform 7 is driven to move into the detection box 1, after detection is completed, the electric push rods 18 are started again to drive the detection platform 7 to remove, thereby the worker is not required to carry out sample feeding and sampling, the automation degree of the device is improved, a limit groove 22 is formed on one side of the interior of the detection platform 7, a limit block 21 is fixedly installed on one side of the placement block 8, the limit block 21 is slidably sleeved with the limit groove 22, by setting the limit block 21, when the slide placement block 8 slides in the detection platform 7, the limit block 21 is slid in the limit groove 22, the position deviation is prevented from occurring in the sliding process of the placement block 8 back and forth, the detection of the optical fiber joint 27 in the fluorescent detection shell 6 is ensured, and the laser irradiation sample cannot be detected.
Example IV
Based on the above embodiments 1, 2 or 3, referring to fig. 1 and 7, an optical fiber connector 27 is disposed in the fluorescent detection housing 6, a laser emitter 25 is disposed on the inner top surface of the fluorescent detection housing 6, the laser emitter 25 is connected with the optical fiber connector 27, a first filter set 26 is disposed outside the laser emitter 25, a second filter set 28 is disposed on the top surface of the optical fiber connector 27, a dichroic mirror 29 is fixedly mounted on the inner top surface of the fluorescent detection housing 6, a spectrometer 30 is fixedly mounted on one side of the inner portion of the fluorescent detection housing 6, by disposing the laser emitter 25, the laser emitter 25 is turned on, ultraviolet wavelength light emitted by the laser emitter 25 forms a laser transmission mechanism through the first filter set 26, and is used for laser irradiation on a sample slide in the placement block 8, and then forms a fluorescent signal acquisition mechanism through the second filter set 28, the dichroic mirror 29 and the spectrometer 30, so as to conduct fluorescent signals generated after excitation.
Working principle: referring to fig. 1-7, a worker opens the sealing plate 3, starts the electric push rod 18 to stretch out, drives the detection platform 7 to move out of the detection box 1, starts the electric push rod 18 to return after the worker places a sample slide in the detection platform 7, drives the detection platform 7 to move into the detection box 1, then starts the laser emitter 25, the laser emitter 25 emits ultraviolet wavelength light to form a laser transmission mechanism through the first filter set 26, the laser transmission mechanism is used for carrying out laser irradiation on the sample slide in the placement block 8, then forms a fluorescent signal acquisition mechanism through the second filter set 28, the dichroic mirror 29 and the spectrometer 30, conducts fluorescent signals generated after excitation, after the fluorescent detection shell 6 detects a sample slide, starts the rotary motor 12, and drives the lead screw 15 to rotate, so that the connecting block 14 of the placement block 8 moves to one side, the next cell 9 moves to the lower side of the fluorescent detection shell 6, thereby carrying out fluorescent detection on a plurality of sample slides, reducing the waste time of single sample feeding, improving the efficiency of fluorescent detection, when the placement block 8 moves in the detection platform 7, then forms a fluorescent signal acquisition mechanism through the second filter set 28, the dichroic mirror 29 and the spectrometer 30, the fluorescent signal generated after the placement block 8 moves to the bottom of the placement block 8 moves, the placement block 8 moves to the bottom the detection block 24, the sliding block is reduced through the bottom the detection block 21, the sliding block is arranged in the sliding block 8, and the sliding block is prevented from moving to the detection box 8, and the position of the sliding block is prevented from moving to the detection box is prevented from moving to the detection result, and the sliding in the detection shell 8 is prevented from sliding in the detection box, and the sliding block is prevented from sliding and the sliding block is moved to be moved to the inside.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. An automatic fluorescence detection apparatus, comprising:
the detection device comprises a detection box (1), wherein a detection port (2) is formed in one side of the detection box (1), a sealing plate (3) is arranged on one side of the detection box (1), the sealing plate (3) is connected with the detection box (1) through a hinge, a plurality of support pads (4) are fixedly arranged on the bottom surface of the detection box (1), a mounting plate (5) is fixedly arranged on the top surface of the inside of the detection box (1), and a fluorescent detection shell (6) is fixedly arranged on the bottom surface of the mounting plate (5);
and the adjusting assembly is arranged in the detection box (1) and is used for adjusting the position of a sample.
2. The automated fluorescence detection apparatus of claim 1, wherein the adjustment assembly comprises:
the detection platform (7), detection platform (7) set up the inside at detection box (1), the inside movable mounting of detection platform (7) has placed piece (8), a plurality of slide glass groove (9) have been seted up to the top surface of placing piece (8), move mouth (11) have been seted up to one side of detection platform (7), one side fixed mounting of detection platform (7) has fixed plate (13), one side fixed mounting of fixed plate (13) has rotating electrical machines (12), one side fixed mounting of placing piece (8) has connecting block (14), connecting block (14) pass to move mouth (11) and extend to the outside of detection platform (7), the axle fixedly connected with lead screw (15) of rotating electrical machines (12), lead screw (15) are in the same place with connecting block (14) threaded connection.
3. An automatic fluorescence detection device according to claim 2, characterized in that the two sides of the detection table (7) are fixedly provided with connecting plates (17), two electric push rods (18) are fixedly arranged on one side of the inside of the detection box (1), and the electric push rods (18) are fixedly connected with the connecting plates (17).
4. An automatic fluorescence detection device according to claim 2, wherein the inner bottom surface of the detection box (1) is provided with a guide groove (19), the bottom surface of the detection table (7) is fixedly provided with a guide block (20), and the guide block (20) and the guide groove (19) are sleeved together in a sliding manner.
5. An automatic fluorescence detection device according to claim 1, characterized in that the inside of the fluorescence detection housing (6) is provided with an optical fiber connector (27), the inside top surface of the fluorescence detection housing (6) is provided with a laser emitter (25), the laser emitter (25) is connected with the optical fiber connector (27), the outside of the laser emitter (25) is provided with a first optical filter set (26), the top surface of the optical fiber connector (27) is provided with a second optical filter set (28), the inside top surface of the fluorescence detection housing (6) is fixedly provided with a dichroic mirror (29), and the inside one side of the fluorescence detection housing (6) is fixedly provided with a spectrometer (30).
6. The automatic fluorescence detection device according to claim 2, wherein a limit groove (22) is formed in one side of the interior of the detection table (7), a limit block (21) is fixedly mounted on one side of the placement block (8), and the limit block (21) and the limit groove (22) are slidably sleeved together.
7. An automatic fluorescence detection device according to claim 2, characterized in that the inner bottom surface of the detection table (7) is provided with a plurality of mounting grooves (23), and the inside of the mounting grooves (23) is rotatably provided with rollers (24).
8. An automatic fluorescence detection device according to claim 2, characterized in that the top surface of the placement block (8) is provided with a number of grooves (10).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311018425.0A CN117129453A (en) | 2023-08-14 | 2023-08-14 | Automatic fluorescence detection equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311018425.0A CN117129453A (en) | 2023-08-14 | 2023-08-14 | Automatic fluorescence detection equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117129453A true CN117129453A (en) | 2023-11-28 |
Family
ID=88852004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311018425.0A Withdrawn CN117129453A (en) | 2023-08-14 | 2023-08-14 | Automatic fluorescence detection equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117129453A (en) |
-
2023
- 2023-08-14 CN CN202311018425.0A patent/CN117129453A/en not_active Withdrawn
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