CN117064345B - Body temperature measuring device for mouse heat production research - Google Patents
Body temperature measuring device for mouse heat production research Download PDFInfo
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- CN117064345B CN117064345B CN202311345415.8A CN202311345415A CN117064345B CN 117064345 B CN117064345 B CN 117064345B CN 202311345415 A CN202311345415 A CN 202311345415A CN 117064345 B CN117064345 B CN 117064345B
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- 230000036760 body temperature Effects 0.000 title claims abstract description 17
- 238000011160 research Methods 0.000 title abstract description 13
- 238000004519 manufacturing process Methods 0.000 title description 4
- 241000699666 Mus <mouse, genus> Species 0.000 claims abstract description 157
- 210000000436 anus Anatomy 0.000 claims abstract description 90
- 238000009529 body temperature measurement Methods 0.000 claims abstract description 59
- 230000007246 mechanism Effects 0.000 claims abstract description 47
- 241000699670 Mus sp. Species 0.000 claims abstract description 42
- 238000005259 measurement Methods 0.000 claims abstract description 10
- 239000000523 sample Substances 0.000 claims description 43
- 230000033001 locomotion Effects 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 10
- 230000005540 biological transmission Effects 0.000 claims description 6
- 241000581650 Ivesia Species 0.000 claims description 4
- 230000009471 action Effects 0.000 claims description 3
- 230000035924 thermogenesis Effects 0.000 claims 10
- 230000020169 heat generation Effects 0.000 abstract description 6
- 230000036544 posture Effects 0.000 description 13
- 238000000034 method Methods 0.000 description 9
- 210000003414 extremity Anatomy 0.000 description 6
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- 230000000968 intestinal effect Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000000476 thermogenic effect Effects 0.000 description 4
- 238000013459 approach Methods 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 2
- 210000000577 adipose tissue Anatomy 0.000 description 2
- 230000001174 ascending effect Effects 0.000 description 2
- 230000008451 emotion Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 208000001034 Frostbite Diseases 0.000 description 1
- 206010021113 Hypothermia Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 210000003486 adipose tissue brown Anatomy 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000037237 body shape Effects 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 238000004146 energy storage Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000002631 hypothermal effect Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000001931 thermography Methods 0.000 description 1
- 238000004861 thermometry Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4866—Evaluating metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
- A61D2003/006—Appliances for supporting or fettering animals for operative purposes with leg or foot restraining means
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Animal Husbandry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Measuring Temperature Or Quantity Of Heat (AREA)
Abstract
The application discloses a body temperature measuring device for mouse heat generation research, which comprises a temperature measuring element and a fixing unit for fixing a mouse; the fixing units are arranged along a working direction and connected to form a fixing module; each fixing unit is correspondingly provided with a temperature measuring element, a plurality of temperature measuring elements are arranged along the working direction, each temperature measuring element is arranged on the mounting frame through the adjusting mechanism, and the temperature measuring elements, the adjusting mechanisms and the mounting frame form a temperature measuring module; during measurement, the distance between the temperature measuring module and the fixing module is shortened, so that each temperature measuring element can reach the anus position of each mouse at the same time, the space position and/or the space posture of the temperature measuring element can be adjusted through the adjusting mechanism, and then each temperature measuring element can measure the anus temperature of the mouse fixed by each fixing unit; after the anal temperature measurement is finished, the distance between the temperature measuring module and the fixed module is increased, and each temperature measuring element simultaneously leaves the anus of each mouse, so that the anal temperature of the mice is measured in batches.
Description
Technical Field
The application belongs to the technical field of medical equipment, and particularly relates to a body temperature measuring device for mouse heat production research.
Background
Mammalian adipose tissue serves as an important energy storage and metabolic regulation organ, playing a vital role in the body's response to the highland environment, with the thermogenic function exerted by brown fat and beige fat being the most important. When the external environment stimulus is applied, the heat-generating adipose tissue produces heat dysfunction which possibly causes symptoms such as hypothermia, limb frostbite necrosis and the like, so that the research on the heat-generating mechanism of the organism has important scientific significance.
Mice are small mammals, and all the time depend on thermogenic fat to exert thermogenic action so as to regulate self metabolism and maintain organism steady state balance, so that the mice are very suitable for researching thermogenic mechanism. In the research of the actual heat generation mechanism, temperature data of a mouse need to be acquired under different experimental conditions, as the body surface of the mouse covers hair, infrared thermal imaging temperature measurement cannot accurately acquire the temperature of the mouse, and a method of inserting a temperature measuring element into the anus of the mouse is used, the acquired temperature data of the anus of the mouse is more accurate, so that when the heat generation research is carried out, the temperature measurement of the anus of the mouse becomes a preferred method, in order to ensure the normal operation of the heat generation research and the accuracy of the acquired experimental data, the temperature of a plurality of batches of the anus of the mouse needs to be measured to acquire enough sample data, a researcher fixes the mouse by one hand, inserts the thermometer into the anus of the mouse by the other hand, the method for acquiring the temperature of the anus of the mouse is low in efficiency, and after inserting the thermometer into the anus of the mouse, a period of time needs to be waited for acquiring the temperature data of the anus, in the process, the researcher needs to fix the mouse and the thermometer all the time, and the researcher cannot work other work, and the method occupies a large amount of manpower.
When the anal temperature measurement is carried out, due to the influences of the body shape and the rectum shape of the mouse, the thermometer is inserted too deeply, damage to the intestinal tract of the mouse is possibly caused, the thermometer is inserted too shallowly, and the accuracy of anal temperature data acquired by the thermometer is influenced, so that a research result is influenced, and in the process, the insertion depth of the thermometer is mainly selected according to the experience of a researcher, so that the research variable is increased, and the research result is influenced.
Disclosure of Invention
In order to improve the measurement efficiency to the mouse anal temperature, conveniently carry out the anal temperature measurement in batches to the mouse, guarantee the accuracy nature of the mouse anal temperature of survey simultaneously to avoid causing the damage to the mouse in the measurement process, this application provides a body temperature measuring device for mouse heat production research.
A body temperature measuring device for mouse heat generation research comprises a temperature measuring element, a fixing unit, an adjusting mechanism and a mounting frame; a temperature measuring element capable of being inserted into the anus of the mouse and measuring the anal temperature of the mouse; a fixing unit capable of fixing the mouse and orienting the anus of the mouse toward the temperature measuring element; the temperature measuring element is connected with the adjusting mechanism, and the adjusting mechanism can adjust the space position and/or the space posture of the temperature measuring element; the fixing units are arranged along a working direction and connected to form a fixing module; each fixing unit is correspondingly provided with a temperature measuring element, a plurality of temperature measuring elements are arranged along the working direction, each temperature measuring element is arranged on the mounting frame through the adjusting mechanism, and the temperature measuring elements, the adjusting mechanisms and the mounting frame form a temperature measuring module; during measurement, the distance between the temperature measuring module and the fixing module is shortened, so that each temperature measuring element can reach the anus position of each mouse at the same time, the space position and/or the space posture of the temperature measuring element can be adjusted through the adjusting mechanism, and then each temperature measuring element can measure the anus temperature of the mouse fixed by each fixing unit; after the anal temperature measurement is finished, the distance between the temperature measuring module and the fixed module is increased, and each temperature measuring element simultaneously leaves the anus of each mouse.
The fixed module can be close to the temperature measurement module, or the temperature measurement module can be close to the fixed module to a plurality of temperature measuring elements can be to the simultaneous measurement of a plurality of mouse anus temperatures, and then improve measurement efficiency. The fixing unit can fix the position of the mouse, the change of the anus position of the mouse is avoided, and because the relative positions between the fixing units are fixed, the distance between the mice fixed by the adjacent fixing units is fixed, the temperature measuring element is connected with the mounting frame through the adjusting mechanism, when the temperature measuring element is close to the anus position of the mouse, the pose of the temperature measuring element can be adjusted in a small range through the adjusting mechanism so as to adapt to the anus positions of the mice with different sizes, the damage of the temperature measuring element to the intestinal tracts of the mice is avoided, the adjusting mechanism and the mounting frame can fix the pose of the temperature measuring element, the temperature measuring element is closer to the anus of the mouse, and after the pose adjustment of the temperature measuring element is finished, the temperature measuring element can be easily inserted into the anus of the mouse by staff to perform the anus temperature measurement, so that the anus temperature measurement operation is more convenient. Because the temperature measuring element is connected with the mounting bracket, the operator can easily carry out the smearing of lubricant to the temperature measuring element.
In one embodiment of the application, the temperature measuring element comprises a temperature measuring probe and a temperature measuring main body, wherein the temperature measuring main body is connected with the mounting frame, and the temperature measuring main body is connected with the anal temperature acquisition instrument through a data transmission line; the temperature measuring probe is detachably connected with the temperature measuring main body through a quick plug electric connection structure.
The temperature measurement probe is repeatedly used under the condition of no disinfection, the propagation of diseases among mice is easy to cause, the temperature measurement probe is connected with the mounting frame through the temperature measurement main body, the temperature measurement probe is connected with the temperature measurement main body in a detachable mode through the quick plug electric connection structure, after the anal temperature measurement of one batch of mice is finished, the anal temperature of the next batch of mice can be measured only by replacing the temperature measurement probe, the condition that the diseases are propagated through the temperature measurement probe among the mice is avoided, the temperature measurement probe is connected with the temperature measurement main body through the quick plug electric connection structure, the temperature measurement main body is connected with the mounting frame, and an operator can easily replace the temperature measurement probe, so that the temperature measurement efficiency is improved.
In one embodiment of the application, the temperature measuring element comprises a temperature measuring probe capable of being inserted into the anus of the mouse, and depth scales are arranged on the outer surface of the temperature measuring probe so as to know the depth of the temperature measuring probe inserted into the anus of the mouse by referring to the depth scales.
The operating personnel can know the degree of depth that temperature probe inserted the mouse anus through the degree of depth scale to select suitable degree of depth according to the mouse of different sizes, avoid temperature probe to damage mouse intestinal, and operating personnel can record temperature probe's depth of insertion when measuring the beginning, record the depth of insertion once more after the temperature measurement, thereby ensure the reliability of temperature measurement result.
In one embodiment of the application, the fixing unit is a fixing box, one side surface of the fixing unit is provided with a first magnet, the side surface opposite to the first magnet is provided with a second magnet, the first magnet and the second magnet can be attracted to each other, and adjacent fixing units can be fixedly connected through attraction between the first magnet and the second magnet.
The fixing units are connected through magnetic attraction, so that the time required for connecting or disassembling the fixing units is shortened, and the assembly efficiency is improved; and the connection between the fixed units has universality in a magnetic attraction connection mode, and the fixed units with any different types can be connected through the first magnet and the second magnet, so that the quantity of the fixed units can be adjusted conveniently.
In an embodiment of the application, the fixed unit is fixed box, and the lid comprises fixed box with end box, and the lid is inside to be equipped with first recess, and end box is equipped with the second recess, and when the lid was click to close at end box, fixed cavity that can fix the mouse was constituteed to first recess and second recess, and fixed cavity is equipped with the opening towards temperature measuring element to expose the mouse anus towards temperature measuring element.
Through lid and end box tap and to form fixed cavity, the mouse can be fixed in fixed cavity, and the mouse anus can expose towards temperature measuring element, this application just through the tap of lid and end box, just accomplished fixed mouse position and expose the mouse anus for the mouse anus has the work of fixed orientation, thereby has significantly reduced the step that fixes the mouse, and has laid the foundation for measuring the mouse anus temperature in batches.
In one embodiment of the application, four fixing holes are formed in the bottom of the second groove, when a mouse is placed in the second groove, four limbs of the mouse can be placed in the fixing holes respectively, and the fixing holes can limit movement of the mouse; the fixed box is equipped with solid tail board in fixed cavity opening part, and solid tail board is equipped with solid tail through-hole, and the mouse tail can pass solid tail through-hole, and solid tail through-hole can restrict the motion of mouse tail.
The movable range of the mice is further limited through the four fixing holes and the tail fixing through holes, so that the situation that the mice twist in the fixing cavity to cause too deep insertion depth of the temperature measuring element to cause intestinal damage of the mice or too shallow temperature measuring element to cause inaccurate temperature measuring result is avoided; the tail fixing through hole can limit the movement of the tail of the mouse, so that the situation that the tail of the mouse shields the anus of the mouse is avoided, the influence of the tail of the mouse on the temperature measuring element can be reduced, the situation that the temperature measuring element is askew and the temperature measuring result is inaccurate is avoided. Through the degree of depth and the shape that set up the fixed orifices, can increase the power degree of difficulty of mouse four limbs to avoid the mouse to twist in fixed cavity, the condition emergence that leads to the fact anus position to change.
In one embodiment of the present application, the groove bottom of the second groove has an upward-inclined extending direction along a direction approaching the temperature measuring module, so that the anus of the mouse placed in the second groove can be exposed obliquely upward.
Through the ascending setting mode of tank bottom slope of second recess, place in the anus of the mouse of second recess can slope upwards expose to make things convenient for operating personnel to confirm the anus position, adjustment mechanism can cooperate the anus orientation, makes temperature measuring element can insert the mouse anus easily.
In an embodiment of the application, the adjustment mechanism comprises a ball hinge structure, the temperature measuring element is connected with the mounting frame through the ball hinge structure, and the angle of the temperature measuring element relative to the fixing unit can be adjusted through the ball hinge structure.
In one embodiment of the application, the adjusting mechanism comprises a bottom rail extending along the working direction, a first guide rail in sliding connection with the bottom rail, and a sliding block in sliding connection with the first guide rail, wherein the bottom rail is connected with the mounting frame, and the temperature measuring element is connected with the sliding block; the extending direction of the first guide rail is perpendicular to the working direction, and the sliding block can move along the first guide rail in the extending direction of the first guide rail, so that the temperature measuring element can be close to or far away from the fixing unit.
In one embodiment of the application, the adjusting mechanism comprises an adjusting screw connected with the mounting frame, two adjusting nuts in threaded fit with the adjusting screw, and a mounting plate provided with an adjusting through hole; the temperature measuring element is connected with the mounting plate; the adjusting screw passes through the adjusting through hole, and the mounting plate is located between two adjusting nuts, and the mounting plate is fixed in position on the adjusting screw under the combined action of two adjusting nuts.
Drawings
FIG. 1 is a schematic structural view of an exemplary embodiment of the present application;
FIG. 2 is a schematic view of an exemplary embodiment of a mouse placed in a second recess;
FIG. 3 is a schematic view of an exemplary embodiment of the mounting boxes arranged in the working direction;
FIG. 4 is a schematic structural view of an exemplary embodiment of a second magnet of the present application;
FIG. 5 is a schematic structural view of an exemplary embodiment of a first magnet of the present application;
FIG. 6 is a schematic structural view of an exemplary embodiment of a second groove of the present application;
FIG. 7 is a schematic diagram of an exemplary embodiment of a securing module of the present application proximate to a thermometry module;
FIG. 8 is a schematic structural view of an exemplary embodiment of a temperature sensing element of the present application;
FIG. 9 is a schematic structural view of an exemplary embodiment of the ball-hinge structure of the present application;
FIG. 10 is a schematic structural view of an exemplary embodiment of the adjustment mechanism of the present application;
FIG. 11 is a combined schematic of an exemplary embodiment of the adjustment mechanism of the present application.
In the figure:
1. a fixed box; 101. a box cover; 102. a bottom box; 103. a first groove; 104. a second groove; 105. a first magnet; 106. a second magnet; 107. a fixing hole; 108. fixing the tail plate; 109. a tail fixing through hole; 110. a sponge;
2. a temperature measuring element; 201. a temperature measurement probe; 202. a temperature measuring main body; 203. a data transmission line; 204. an anal temperature acquisition instrument; 205. depth scale; 206. the quick plug electric connection structure;
3. an adjusting mechanism; 301. a bottom rail; 302. a first guide rail; 303. a slide block; 304. a mounting plate; 305. adjusting the through hole; 306. adjusting a screw; 307. a ball hinge structure; 308. a spring clip; 309. an adjusting nut;
4. a mounting frame;
5. and (3) a mouse.
Detailed Description
For a clearer understanding of the technical features, objects, and effects of the present application, embodiments of the present application will now be described with reference to the drawings, wherein like reference numerals designate identical or structurally similar but functionally identical components throughout the various views.
In this document, "schematic" means "serving as an example, instance, or illustration," and any illustrations, embodiments described herein as "schematic" should not be construed as a more preferred or advantageous solution.
For simplicity of the drawing, only the parts relevant to the present application are schematically shown in each drawing, and they do not represent the actual structure thereof as a product. In addition, for simplicity and ease of understanding, components having the same structure or function in some of the figures are shown schematically only one of them, or only one of them is labeled.
Referring to fig. 1, 2 and 3, a body temperature measuring device for a mouse heat generation study comprises a temperature measuring element 2, a fixing unit, an adjusting mechanism 3 and a mounting frame 4. A temperature measuring element 2 capable of being inserted into the anus of the mouse and measuring the temperature of the anus of the mouse; the fixing unit is a fixing box 1 which can fix the mice and lead the anus of the mice to face the temperature measuring element 2; the temperature measuring element 2 is connected with the adjusting mechanism 3, the adjusting mechanism 3 can adjust the space position and/or the space posture of the temperature measuring element 2, and the temperature measuring element 2 is arranged on the mounting frame 4 through the adjusting mechanism 3. During measurement, the plurality of temperature measuring elements 2 can reach the positions near the anus of the plurality of mice 5 at the same time, and the space positions and the space postures of the temperature measuring elements 2 can be adjusted through the adjusting mechanism 3, or only the space positions of the temperature measuring elements 2 are adjusted, or only the space postures of the temperature measuring elements 2 are adjusted, after the position postures of the temperature measuring elements 2 are adjusted, the temperature measuring elements 2 are further close to the anus of the mice, so that the temperature measuring elements 2 are inserted into the anus of the mice, and then each temperature measuring element 2 can perform anal temperature measurement on the mice 5 fixed by each fixing box 1; after the anal temperature measurement is finished, the distance between the temperature measuring module and the fixed module is increased, and each temperature measuring element 2 simultaneously leaves the anus of each mouse.
Referring to fig. 1 to 5, in one embodiment of the present application, the fixing unit is a fixing case 1, the case cover 101 and the bottom case 102 form the fixing case 1, a first groove 103 is provided inside the case cover 101, the bottom case 102 is provided with a second groove 104, when the case cover 101 is knocked on the bottom case 102, the first groove 103 and the second groove 104 form a fixing cavity capable of fixing the mouse 5, and the fixing cavity is provided with an opening facing the temperature measuring element 2 so as to expose the anus of the mouse toward the temperature measuring element 2. Through lid 101 and end box 102 tap and form fixed cavity, the mouse can be fixed in fixed cavity, and the mouse anus can be exposed towards temperature measuring element 2, this application just has accomplished fixed mouse position and has exposed the mouse anus through the tap of lid 101 and end box 102, make the mouse anus have the work of fixed orientation, thereby the required step of mouse fixation has significantly reduced, and establish the basis for measuring the mouse anus temperature in batches, and can set up suitable lid 101 weight, utilize the weight of lid 101 to prevent that the mouse from taking place with lid 101 top-open's condition, thereby the fixed box 1 of convenient fixed box 1 is to the fixed mouse.
The first groove 103 can be attached to the back shape of a mouse, the second groove 104 can be attached to the abdomen shape of the mouse, the first groove 103 and the second groove 104 can provide comfortable environment for the mouse while fixing the mouse 5, so that tension emotion of the mouse in the fixing box 1 is relieved, anal temperature fluctuation of the mouse is reduced, and the measurement result of the anal temperature of the mouse is more accurate.
Referring to fig. 4 and 5, the box cover 101 and the bottom box 102 can be pivotally connected through a 90 ° limit hinge, and the box cover 101 can rotate around a pivot shaft of the 90 ° limit hinge, so that the fixed box 1 is opened or closed, and a mouse is more convenient to put into the fixed box 1 or take out from the fixed box 1.
Referring to fig. 2, fig. 4, and fig. 5, further, in an embodiment of the present application, four fixing holes 107 are formed at the bottom of the second groove 104, when a mouse is placed in the second groove 104, referring to fig. 2, four limbs of the mouse can be placed in the fixing holes 107 respectively, and the fixing holes 107 can limit movement of the mouse; the fixed box 1 is provided with a tail fixing plate 108 at the opening of the fixed cavity, and referring to fig. 2, the box cover 101 is provided with the tail fixing plate 108, the tail fixing plate 108 is provided with a tail fixing through hole 109, the tail of the mouse can pass through the tail fixing through hole 109, and the tail fixing through hole 109 can limit the movement of the tail of the mouse.
The movable range of the mice is further limited through the four fixing holes 107 and the tail fixing through holes 109, so that the situation that the mice twist in the fixing cavity to cause too deep insertion depth of the temperature measuring element 2 to cause intestinal damage of the mice or too shallow of the temperature measuring element 2 to cause inaccurate temperature measuring results is avoided; the tail fixing through hole 109 can limit the movement of the tail of the mouse, so that the situation that the tail of the mouse shields the anus of the mouse is avoided, the influence of the tail of the mouse on the temperature measuring element 2 can be reduced, the situation that the temperature measuring element 2 is askew and inaccurate in temperature measuring result is avoided. Through setting up the degree of depth and the shape of fixed orifices 107, can increase the power degree of difficulty of mouse four limbs to avoid the mouse to twist in fixed cavity, the condition emergence that leads to the fact anus position to change.
The four fixing holes 107 and the tail fixing through holes 109 can prevent the limbs of the mouse from being contracted in the fixing cavity while fixing the mouse, thereby improving the comfort of the mouse during fixing and further reducing the body temperature fluctuation of the mouse caused by tension and other emotions.
It can be understood by those skilled in the art that the tail fixing plate 108 in the present application can be disposed on the box cover 101, and also can be disposed on the bottom box 102, and the tail of the mouse can be fixed by the tail fixing through hole 109 disposed on the tail fixing plate 108.
Referring to fig. 6, in one embodiment of the present application, the groove bottom of the second groove 104 has an upward-inclined extension direction in a direction approaching the thermometric module, so that the buttocks of the mouse are tilted upward due to the abdomen of the mouse attached to the groove bottom of the second groove 104, so that the anus of the mouse placed in the second groove 104 can be exposed obliquely upward.
Through the ascending setting mode of tank bottom slope of second recess 104, place in the anus of the mouse of second recess 104 can slope upwards expose to make things convenient for operating personnel to confirm the anus position, adjustment mechanism 3 can cooperate the anus orientation, makes temperature measuring element 2 can insert the mouse anus easily.
Of course, it can be understood by those skilled in the art that the first groove 103 or the second groove 104, or the first groove 103 and the second groove 104 can be provided with a flexible and elastic material, such as a sponge 110, a foam, and the like, see fig. 4, and the sponge 110 can protect a mouse on one hand, and can further compress a mouse moving space on the other hand, so as to avoid the situation that the anus of the mouse moves in the anal temperature measurement process.
Referring to fig. 1, 4 and 5, in one embodiment of the present application, a first magnet 105 is provided on one side of the fixed case 1, a second magnet 106 is provided on the side opposite to the first magnet 105, the first magnet 105 and the second magnet 106 are attracted to each other, and adjacent fixed cases 1 are fixedly connected by attraction between the first magnet 105 and the second magnet 106.
The fixed boxes 1 are connected through magnetic attraction, so that detachable connection between adjacent fixed boxes 1 is realized, and the connection mode of the magnetic attraction connection between the fixed boxes 1 shortens the time required by connection or disassembly between the fixed boxes 1, thereby improving the assembly efficiency; and make the connection between the fixed box 1 have universality through the mode of magnetic connection, all can connect through first magnet 105, second magnet 106 between the fixed box 1 of arbitrary difference to the convenience is adjusted fixed box 1 quantity.
Preferably, the first magnet 105 is disposed on the surface of the protrusion, the second magnet 106 is disposed in the groove, as shown in fig. 4 and 5, the first magnet 105 on the protrusion of two adjacent fixing boxes 1 and the second magnet 106 in the groove are attracted to each other, so that the two adjacent fixing boxes 1 are magnetically connected, and the protrusion and the groove between the two adjacent fixing boxes 1 can be clamped, so that the two fixing boxes 1 can be relatively fastened to each other, and relative movement between the two adjacent fixing boxes 1 in the operation process is avoided.
Of course, the connection between the fixing case 1 and the fixing case 1 may be a non-detachable connection, so that the number of fixing units in the fixing module is fixed, and the maximum measurable number of mice at a time is fixed.
The person skilled in the art can understand that the setting mode of the fixing unit in the application is not limited to the mode of the fixing box 1, but other modes, such as setting the fixing plate, setting a plurality of elastic nets along the extending direction of the fixing plate, so as to place the mouse between the elastic net and the fixing plate, and then fix the mouse on the fixing plate.
The fixing boxes 1 are arranged along a working direction, the fixing boxes 1 are connected to form a fixing module, and the anus positions of the mice are approximately the same relative to the positions of the fixing boxes 1 due to the fact that the sizes and the shapes of the fixing boxes 1 are the same, so that the anus positions of the mice are located near the same reference line; each fixed box 1 is correspondingly provided with a temperature measuring element 2, a plurality of temperature measuring elements 2 are arranged along the working direction, each temperature measuring element 2 is arranged on a mounting frame 4 through an adjusting mechanism 3, and a temperature measuring module is formed by the plurality of temperature measuring elements 2, the plurality of adjusting mechanisms 3 and the mounting frame 4; during measurement, the temperature measuring module is close to the fixing module, the distance between the temperature measuring module and the fixing module is shortened, so that each temperature measuring element 2 can reach the vicinity of the anus of each mouse at the same time, the space position and the space posture of the temperature measuring element 2 can be adjusted through the adjusting mechanism 3, or the space position of the temperature measuring element 2 is only adjusted, or the space posture of the temperature measuring element 2 is only adjusted, after the position posture of the temperature measuring element 2 is adjusted, the temperature measuring element 2 is further close to the anus of the mouse, the temperature measuring element 2 is inserted into the anus of the mouse, and then each temperature measuring element 2 can perform anus temperature measurement on the mouse fixed by each fixing box 1; after the anal temperature measurement is finished, the distance between the temperature measuring module and the fixed module is increased, and each temperature measuring element 2 simultaneously leaves the anus of each mouse.
The utility model belongs to the technical field's of this application and can understand, realize that temperature measurement module is close to fixed module's realization mode has multiple, like the direct handheld mounting bracket 4 of operating personnel, place the opening part of fixed box 1 with mounting bracket 4 for each temperature measurement element 2 is close to the anus position of each mouse, also the accessible mounting bracket 4 is equipped with the guide rail, temperature measurement element 2 is connected with bottom rail 301, bottom rail 301 and the guide rail sliding connection's of mounting bracket 4 mode, thereby when bottom rail 301 moves along the guide rail of mounting bracket 4, can drive temperature measurement element 2 motion, with be close to or keep away from fixed module.
As can be appreciated by those skilled in the art, the implementation manner of shortening the distance between the temperature measuring module and the fixed module is not limited to the manner that the temperature measuring module approaches the fixed module, but may be that the fixed module approaches the temperature measuring module, referring to fig. 7, the fixed module is connected with the bottom rail 301, and the bottom rail 301 is slidably connected with the guide rail provided on the mounting frame 4, so that when the bottom rail 301 slides along the guide rail provided on the mounting frame 4, the fixed module is driven to approach the temperature measuring module; or fixed module, temperature measurement module are close to each other, if fixed module locates on the fixed crossbeam, fixed crossbeam and guide rail sliding connection, mounting bracket 4 also with guide rail sliding connection to fixed module can be along the guide rail and be close to temperature measurement module, or fixed module, temperature measurement module are along the guide rail and be close to each other.
The fixing module can be close to the temperature measuring module, or the temperature measuring module can be close to the fixing module, so that the temperature measuring elements 2 can measure the anal temperature of a plurality of mice at the same time, and the measuring efficiency is improved; and the fixed unit can fix the position of mouse, avoid mouse anus position to change, and because the relative position between each fixed unit is fixed, then the fixed mouse of adjacent fixed unit between the distance between is fixed, temperature measuring element 2 passes through adjustment mechanism 3 and is connected with mounting bracket 4, when temperature measuring element 2 is close to mouse anus position, can carry out the adjustment of a small scale to temperature measuring element 2's position appearance through adjustment mechanism 3, in order to adapt to the mouse anus position of different sizes, avoid temperature measuring element 2 to cause the damage to the mouse intestinal, adjustment mechanism 3 and mounting bracket 4 can fix temperature measuring element 2's position appearance, and temperature measuring element 2 is nearer to mouse anus, after the position appearance adjustment of temperature measuring element 2, can easily insert temperature measuring element 2 into mouse anus, carry out the anus temperature measurement, anus temperature measurement operation is more convenient.
Referring to fig. 1 and 8, in one embodiment of the present application, a temperature measuring element 2 includes a temperature measuring probe 201 and a temperature measuring main body 202, the temperature measuring main body 202 is connected with a mounting frame 4, and the temperature measuring main body 202 is connected with an anal temperature collector 204 through a data transmission line 203; the temperature measurement probe 201 is detachably connected with the temperature measurement main body 202 through the quick plug electrical connection structure 206, see fig. 8, the temperature measurement probe 201 is connected with a positive head, and the temperature measurement main body 202 is connected with a negative head, so that the temperature measurement probe 201 is electrically connected with the temperature measurement main body 202 through the positive head and the negative head, and the quick plug of the temperature measurement probe 201 and the temperature measurement main body 202 is realized.
The temperature probe 201 is repeatedly used under the condition of no disinfection, the spread of diseases among mice is easy to cause, the temperature probe 201 is connected with the mounting frame 4 through the temperature measurement main body 202, the temperature probe 201 is detachably connected with the temperature measurement main body 202 through the quick plug electric connection structure 206, after the anal temperature measurement of one batch of mice is finished, the anal temperature of the next batch of mice can be measured only by replacing the temperature probe 201, the occurrence of the condition of disease spread caused by the temperature probe 201 among the mice is avoided, the temperature probe 201 is connected with the temperature measurement main body 202 through the quick plug electric connection structure 206, the temperature measurement main body 202 is connected with the mounting frame 4, and an operator can easily replace the temperature probe 201, so that the temperature measurement efficiency is improved. Meanwhile, the temperature measuring probe 201 with proper size can be selected according to the body types of different mice, so that inaccurate temperature measuring results caused by too thick or too thin, too long or too short temperature measuring probes 201 and damage to the mice are avoided.
The length of the data transmission line 203 with proper length can be set, so that when the temperature measuring element 2 is close to the fixed module, the data transmission line 203 with sufficient length can ensure the electric connection between the temperature measuring element 2 and the anal temperature acquisition instrument 204, and the normal operation of the mouse anal temperature acquisition work can be ensured.
Referring to fig. 8, in one embodiment of the present application, the temperature measuring element 2 includes a temperature measuring probe 201 capable of being inserted into the anus of a mouse, and a depth scale 205 is provided on an outer surface of the temperature measuring probe 201 to know the depth of the temperature measuring probe 201 inserted into the anus of the mouse with reference to the depth scale 205.
The operating personnel can know the degree of depth that temperature probe 201 inserted the mouse anus through degree of depth scale 205 to select suitable degree of depth according to the mouse of different sizes, avoid temperature probe 201 to damage the mouse intestinal, and operating personnel can record the degree of depth of inserting of temperature probe 201 when measuring the beginning, record the degree of depth of inserting once more after the temperature measurement, thereby ensure the reliability of temperature measurement result.
Those skilled in the art to which the present application pertains will appreciate that there are various implementations of adjusting the spatial position and the spatial posture of the temperature measuring element 2 by the adjusting mechanism 3, or adjusting only the spatial position of the temperature measuring element 2, or adjusting only the spatial posture of the temperature measuring element 2, as described in detail below.
Referring to fig. 1 and 9, in one embodiment of the present application, the adjusting mechanism 3 includes a ball hinge structure 307, the ball hinge structure 307 is connected with the mounting frame 4 through the bottom rail 301, one end of the spring clip 308 clamps the temperature measuring element 2, the other end is provided with a ball head in the ball hinge structure 307, the bottom rail 301 is connected with a ball head sleeve in the ball hinge structure 307, the ball head can be in ball hinge connection with the ball head sleeve, the temperature measuring element 2 is connected with the bottom rail 301 through the ball hinge structure 307, the temperature measuring element 2 can swing up and down and left and right through the ball hinge structure 307, the angle of the temperature measuring element 2 relative to the fixed unit can be adjusted through the ball hinge structure 307, so that the angle of the temperature measuring element 2 relative to the anus of the mouse can be adjusted, as described above, the temperature measuring element 2 can be inclined downward toward the temperature measuring element 2 through the ball hinge structure 307, so as to match the direction of the anus of the mouse, and the spatial posture and the spatial position of the temperature measuring element 2 can also be changed by using the ball hinge structure 307, so that the probe 201 of the temperature measuring element 2 can be easily inserted into the anus of the mouse.
Referring to fig. 1, 9, 10 and 11, in one embodiment of the present application, the adjusting mechanism 3 includes an adjusting screw 306 connected to the mounting frame 4, two adjusting nuts 309 screwed with the adjusting screw 306, and a mounting plate 304 provided with an adjusting through hole 305, where the mounting plate 304, the adjusting screw 306 and the adjusting nuts 309 form a height adjusting structure, referring to fig. 9 and 10, and the mounting plate 304 is connected to the mounting frame 4 through a bottom rail 301; the temperature measuring element 2 is connected with the mounting plate 304; the adjusting screw 306 passes through the adjusting through hole 305, the mounting plate 304 is positioned between the two adjusting nuts 309, the mounting plate 304 is fixed at the position on the adjusting screw 306 under the combined action of the two adjusting nuts 309, the ball sleeve is connected to the mounting plate 304, so that the temperature measuring element 2 is connected with the mounting frame 4 through the spring clamp 308, the ball hinge structure 307, the mounting plate 304, the adjusting screw 306 and the bottom rail 301, the spatial posture and the spatial position of the temperature measuring element 2 can be changed by utilizing the ball hinge structure 307, and meanwhile, the height of the temperature measuring element 2 relative to the fixed box 1 can be changed by changing the height of the mounting plate 304 relative to the bottom rail 301, so that the temperature measuring element 2 can perform anal temperature measurement on mouse anus at different positions.
Referring to fig. 1, 9, 10 and 11, in one embodiment of the present application, the adjusting mechanism 3 includes a bottom rail 301 extending along a working direction, a first guide rail 302 slidably connected to the bottom rail 301, and a slider 303 slidably connected to the first guide rail 302, the bottom rail 301 is connected to the mounting frame 4, the mounting plate 304 is connected to the slider 303 through an adjusting screw 306, so that the temperature measuring element 2 is connected to the slider 303 through a spring clip 308, a ball hinge 307, the mounting plate 304, and the adjusting screw 306, the slider 303 is capable of moving along the bottom rail 301 through the first guide rail 302, so that the temperature measuring element 2 is capable of moving in the working direction, so that the temperature measuring element 2 is capable of moving left and right in a direction shown in fig. 2, relative to the fixed box 1, the first guide rail 302 extends in a direction perpendicular to the working direction, and the slider 303 is capable of moving in an extending direction of the first guide rail 302, so that the slider 303 is capable of moving along the first guide rail 302 toward or away from the fixed box 1, so that the temperature measuring element 2 is capable of moving toward or away from the fixed unit, so that the temperature measuring element 2 is capable of changing the spatial position of the temperature measuring element 2, so as to adjust the position of the mouse.
As will be appreciated by those skilled in the art, since the plurality of adjustment mechanisms 3 each include a bottom rail 301, the plurality of bottom rails 301 extend in the working direction, and the plurality of bottom rails 301 can be replaced by one bottom rail 301.
It can be understood by those skilled in the art that the ball hinge structure 307, the height adjusting structure, the sliding block 303, the first guide rail 302 and the bottom rail 301 in the present application are not limited to be used in combination, but can be used alone, for example, the ball sleeve is fixedly connected with the bottom rail 301, the temperature measuring element 2 is directly connected with the bottom rail 301 through the spring clip 308 and the ball hinge structure 307, or the temperature measuring element 2 is fixedly connected with the mounting plate 304, the adjusting screw 306 and the bottom rail 301, or the temperature measuring element 2 is directly connected with the sliding block 303, so that the temperature measuring element 2 is connected with the first guide rail 302 and the bottom rail 301 through the sliding block 303, or the ball hinge structure 307 is used in combination with the sliding block 303, the first guide rail 302 and the bottom rail 301, or the height adjusting structure is used in combination with the sliding block, the first guide rail 302 and the bottom rail 301, and the height adjusting structure is not described herein.
It should be understood that although the present disclosure has been described in terms of various embodiments, not every embodiment is intended to include only a single embodiment, and such description is for clarity only, and those skilled in the art will recognize that the embodiments described herein may be suitably combined to form other embodiments as would be understood by those skilled in the art.
The above list of detailed descriptions is only specific to practical examples of the present application, and they are not intended to limit the scope of the present application, and all equivalent embodiments or modifications, such as combinations, divisions or repetitions of features, without departing from the technical spirit of the present application are included in the scope of the present application.
Claims (10)
1. A body temperature measurement device for use in a thermogenesis study of mice, comprising:
a temperature measuring element capable of being inserted into the anus of the mouse and measuring the anal temperature of the mouse;
a fixing unit capable of fixing the mouse and orienting an anus of the mouse toward the temperature measuring element;
the temperature measuring element is connected with the adjusting mechanism, and the adjusting mechanism can adjust the space position and/or the space posture of the temperature measuring element;
the fixing units are arranged along a working direction, and the fixing units are connected to form a fixing module;
the fixing units are correspondingly provided with the temperature measuring elements, a plurality of temperature measuring elements are arranged along the working direction and are arranged on the mounting frame through the adjusting mechanism, and the temperature measuring elements, the adjusting mechanisms and the mounting frame form a temperature measuring module;
during measurement, the distance between the temperature measuring module and the fixing module is shortened, so that each temperature measuring element can reach the anus position of each mouse at the same time, the space position and/or the space posture of the temperature measuring element can be adjusted through the adjusting mechanism, and then each temperature measuring element can measure the anus temperature of the mouse fixed by each fixing unit; after the anal temperature measurement is finished, the distance between the temperature measuring module and the fixing module is increased, and each temperature measuring element leaves the anus of each mouse at the same time.
2. A body temperature measuring device for use in thermogenesis studies in mice according to claim 1, wherein,
the temperature measuring element comprises a temperature measuring probe and a temperature measuring main body, the temperature measuring main body is connected with the mounting frame, and the temperature measuring main body is connected with the anal temperature acquisition instrument through a data transmission line;
the temperature measuring probe is detachably connected with the temperature measuring main body through a quick plug electric connection structure.
3. A body temperature measuring device for use in thermogenesis studies in mice according to claim 1, wherein,
the temperature measuring element comprises a temperature measuring probe capable of being inserted into the anus of the mouse, and depth scales are arranged on the outer surface of the temperature measuring probe so as to know the depth of the temperature measuring probe inserted into the anus of the mouse according to the depth scales.
4. A body temperature measuring device for use in thermogenesis studies in mice according to claim 1, wherein,
the fixing unit is a fixing box, a first magnet is arranged on one side face of the fixing unit, a second magnet is arranged on the side face opposite to the first magnet, the first magnet and the second magnet can be attracted mutually, and adjacent fixing units can be fixedly connected through attraction between the first magnet and the second magnet.
5. A body temperature measuring device for use in thermogenesis studies in mice according to claim 1, wherein,
the fixing unit is a fixing box, the box cover and the bottom box form the fixing box, a first groove is formed in the box cover, a second groove is formed in the bottom box, the box cover is knocked on the bottom box, the first groove and the second groove form a fixing cavity capable of fixing a mouse, and the fixing cavity is provided with an opening facing the temperature measuring element so as to expose the anus of the mouse toward the temperature measuring element.
6. A body temperature measuring device for use in thermogenesis studies in mice according to claim 5, wherein,
four fixing holes are formed in the bottom of the second groove, when a mouse is placed in the second groove, four limbs of the mouse can be placed in the fixing holes respectively, and the fixing holes can limit movement of the mouse;
the fixed box is in fixed cavity opening part is equipped with solid tail board, solid tail board is equipped with solid tail through-hole, and the mouse tail can pass solid tail through-hole, solid tail through-hole can restrict the motion of mouse tail.
7. A body temperature measuring device for use in thermogenesis studies in mice according to claim 5, wherein,
along the direction close to the temperature measuring module, the bottom of the second groove is provided with an upward inclined extending direction, so that the anus of the mouse placed in the second groove can be exposed obliquely upward.
8. A body temperature measuring device for use in thermogenesis studies in mice according to claim 1, wherein,
the adjusting mechanism comprises a ball hinge structure, the temperature measuring element is connected with the mounting frame through the ball hinge structure, and the angle of the temperature measuring element relative to the fixing unit can be adjusted through the ball hinge structure.
9. A body temperature measuring device for use in thermogenesis studies in mice according to claim 1, wherein,
the adjusting mechanism comprises a bottom rail extending along the working direction, a first guide rail in sliding connection with the bottom rail, and a sliding block in sliding connection with the first guide rail, wherein the bottom rail is connected with the mounting frame, and the temperature measuring element is connected with the sliding block;
the extending direction of the first guide rail is perpendicular to the working direction, and the sliding block can move along the first guide rail in the extending direction of the first guide rail, so that the temperature measuring element can be close to or far away from the fixing unit.
10. A body temperature measuring device for use in thermogenesis studies in mice according to claim 1, wherein,
the adjusting mechanism comprises an adjusting screw rod connected with the mounting frame, two adjusting nuts in threaded fit with the adjusting screw rod, and a mounting plate provided with an adjusting through hole;
the temperature measuring element is connected with the mounting plate;
the adjusting screw rod passes through the adjusting through hole, the mounting plate is positioned between the two adjusting nuts, and the mounting plate is fixed at the position on the adjusting screw rod under the combined action of the two adjusting nuts.
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