CN117025296A - 一种精油组合物及其应用 - Google Patents
一种精油组合物及其应用 Download PDFInfo
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- CN117025296A CN117025296A CN202310414058.XA CN202310414058A CN117025296A CN 117025296 A CN117025296 A CN 117025296A CN 202310414058 A CN202310414058 A CN 202310414058A CN 117025296 A CN117025296 A CN 117025296A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0003—Compounds of unspecified constitution defined by the chemical reaction for their preparation
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
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- A—HUMAN NECESSITIES
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- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
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- A—HUMAN NECESSITIES
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
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- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/24—Lauraceae [Laurel family], e.g. laurel, avocado, sassafras, cinnamon or camphor
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- A—HUMAN NECESSITIES
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- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/28—Myrtaceae [Myrtle family], e.g. teatree or clove
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
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Abstract
本发明涉及植物精油技术领域,具体公开一种精油组合物及其应用。所述精油组合物包括如下组分:香芹酚;百里香酚;柠檬油;薄荷油;月桂叶油;广藿香油;天竺葵油;紫苏油;肉桂油;丁香油和山苍子油。本发明提供的精油组合物天然环保、杀菌效果好、气味舒适、无明显皮肤刺激性、对人体无害、对环境友好,能够应用到制备抗微生物的制品中。
Description
技术领域
本发明涉及植物精油技术领域,尤其涉及一种精油组合物及其应用。
背景技术
随着人们活动范围的扩大,以及生活方式的多样性,人类每天都会生成大量的生活垃圾,其中含有大量的细菌和病毒,有些会随空气的流动漂浮空中,威胁着人们的健康。很多高致病性微生物病原体引起迅速发作和蔓延的传染病。这样的传染病甚至能在短时间内跨越数省、数国乃至在全世界范围内流行,即,迅速发展为“大流行(pandemic)”。
大流行期间,消杀是疫情防控的一项重要工作。目前,世界范围内通常使用合成化学品类消杀产品(如乙醇、过氧乙酸、含氯消毒剂、酚类消毒剂等)、紫外线、热等来灭活致病性微生物。长期使用这些消毒剂,会造成病菌耐受性的增强,使得杀菌消毒效果逐渐变弱,且这些消毒剂对人体的呼吸系统、皮肤和粘膜均有较大的刺激作用,使用不当会对人体造成一定伤害。
基于天然植物的精油产品传统上用于治疗传染病和疫情防控已有数千年历史,植物精油又称香精油或者芳香油,是具有一定香味的挥发性油状液体的总称,为植物体内产生的次生代谢产物,属脂肪族、芳香族、萜类化合物及含氮含硫化合物。植物精油中的部分成分,具有杀菌的功能,但植物精油也存在会刺激皮肤,杀菌效率低的问题。
对微生物的杀灭或抑制可分为灭菌、消毒、杀菌、抗菌与抑菌多个层次,其中,杀菌是指杀死微生物营养体和繁殖体的作用(效果评价参照《消毒技术规范》2002年版-2.1.1.7定量杀灭试验和《消毒技术规范》2002年版-2.1.1.9定量杀灭试验);抑菌是指防止或抑制微生物生长繁殖的作用(效果评价参照《消毒技术规范》2002年版-2.1.11.3的抑菌率检测方法);抗菌是指抑菌和杀菌作用的总称。
虽然专利WO2022/068977A2中公开了一种抗微生物精油组合物,由香芹酚、百里香酚、柠檬油、亚洲薄荷素油等组成,具有显著的抗病毒(如抗新冠病毒)、抑菌(如对大肠杆菌、金黄色葡萄球菌、白色念珠菌有良好的抑菌作用)功效等,但该专利中未公开该精油组合物及其稀释液的杀菌效果,且该精油组合物的空气消毒效果不够理想。
因此,需要提供对人体无害,对环境友好,符合绿色环保、可持续发展趋势,且具有抗微生物活性,尤其是具有良好杀菌功效和空气消毒功效的植物精油类产品。
发明内容
针对现有植物精油存在的上述技术问题,本发明提供一种精油组合物及其应用。
为达到上述发明目的,本发明采用了如下的技术方案:
一种精油组合物,包括如下质量份数的组分:香芹酚3~7份;百里香酚0.08~0.4份;柠檬油0.076~1.45份;薄荷油0.08~1.24份;月桂叶油0.24~0.45份;广藿香油0.01~0.42份;天竺葵油0.004~0.24份;紫苏油0.04~0.4份;肉桂油35~60份;丁香油0.08~22份和山苍子油0.08~17份。
进一步地,所述的精油组合物,包括如下质量份数的组分:香芹酚4.5~6.8份;百里香酚0.2~0.4份;柠檬油0.95~1.45份;薄荷油0.7~1.24份;月桂叶油0.3~0.45份;广藿香油0.01~0.02份;天竺葵油0.12~0.24份;紫苏油0.25~0.4份;肉桂油50~55份;丁香油0.08~3.2份和山苍子油0.08~1份。
进一步地,所述的精油组合物,包括如下质量份数的组分:香芹酚3~5份;百里香酚0.08~0.12份;柠檬油0.08~0.12份;薄荷油0.08~0.12份;月桂叶油0.24~0.36份;广藿香油0.2~0.4份;天竺葵油0.004~0.008份;紫苏油0.04~0.08份;肉桂油35~45份;丁香油16~22份和山苍子油12~17份。
进一步地,所述的精油组合物,包括如下质量份数的组分:香芹酚5.673份;百里香酚0.276份;柠檬油1.208份;薄荷油1.035份;月桂叶油0.345份;广藿香油0.017份;天竺葵油0.173份;紫苏油0.328份;肉桂油55份;丁香油0.1份和山苍子油0.1份。
进一步地,所述的精油组合物,包括如下质量份数的组分:香芹酚4.5份;百里香酚0.39份;柠檬油0.95份;薄荷油0.75份;月桂叶油0.45份;广藿香油0.02份;天竺葵油0.24份;紫苏油0.4份;肉桂油52份;丁香油3份和山苍子油0.5份。
进一步地,所述的精油组合物,包括如下质量份数的组分:香芹酚3.9份;百里香酚0.1份;柠檬油0.095份;薄荷油0.1份;月桂叶油0.3份;广藿香油0.35份;天竺葵油0.005份;紫苏油0.05份;肉桂油40份;丁香油20份和山苍子油15份。
进一步地,所述的精油组合物,包括如下质量份数的组分:香芹酚3份;百里香酚0.12份;柠檬油0.1份;薄荷油0.12份;月桂叶油0.25份;广藿香油0.2份;天竺葵油0.008份;紫苏油0.07份;肉桂油45份;丁香油17份和山苍子油13份。
进一步地,上述精油组合物,还包括如下质量份数的组分:桂花油5~12份和柠檬草油2~12份。
其中,上述薄荷油为亚洲薄荷油、椒样薄荷精油(欧薄荷油)中的一种或两种。
本发明还提供了上述精油组合物的制备方法,包括如下步骤:将各组分在常温常压下混合,搅拌至百里香酚溶解,即得。
相对于现有技术,本发明提供的精油组合物,多种精油成分之间存在活性的互补和加成,相比于单方精油,实现了预料不到的协同作用,获得了显著更好的抗微生物(“抗微生物”是指所用的产品具有减少/杀灭微生物的活性)性质,该精油组合物对大肠杆菌、金黄色葡萄球菌、白色念珠菌有良好的杀菌作用,且对空气中的白色葡萄球菌具有良好的杀灭作用。同时,该精油组合物采用纯天然植物精油制成,与传统的合成化学品类消杀产品相比,天然环保、杀菌消毒效果好、气味舒适、无明显皮肤刺激性、对环境友好。
本发明还提供了上述精油组合物在抗微生物中的应用。
进一步地,所述微生物选自细菌、真菌及其组合。
进一步地,所述细菌为革兰氏阴性菌或革兰氏阳性菌中的一种或多种。
进一步地,所述革兰氏阴性菌包括卡他球菌、大肠杆菌、铜绿假单胞菌、痢疾杆菌中的一种或多种;所述革兰氏阳性菌包括肺炎链球菌、白色葡萄球菌、金黄色葡萄球菌、痤疮丙酸杆菌、表皮葡萄球菌中的一种或多种;所述真菌包括霉菌、酵母菌、白色念珠菌、马拉色菌中的一种或多种。
本发明还提供了包含上述精油组合物的制品。
上述制品可以包括能够对环境、物表或人体进行微生物消杀的制品,即对人体无毒性、无刺激性、无腐蚀性、对环境友好并且能够减少或杀灭环境中、物表或人体上的有害微生物的制品。
进一步地,所述制品包括用于抑制或杀灭硬表面、多孔表面、纺织品表面、皮肤、粘膜、毛发中的一种或多种上的微生物的制品或用于抑制或杀灭空气中的微生物的制品。
进一步地,所述制品为选自药品、消毒产品、防护用品、保健食品、食品、膳食补充剂、日化产品、纺织品中的一种或多种。
进一步地,所述制品为化妆品、个人清洁护理用品或日常洗涤用品。
进一步地,所述制品为选自爆珠、湿巾、织物除菌液、肥皂、香皂、洗衣液、洗洁精、祛痘膏、护手霜、空气清新剂、香薰、香水、牙膏、口腔喷雾、鼻吸棒、洗手液、洗发水、护发素、沐浴液、空气消毒凝胶、空气消毒剂、油污清洁剂、皮肤消毒剂、皮肤抑菌喷雾中的一种或多种。
进一步地,所述制品为选自内衣、内裤、卫生巾、床单、袜子、鞋垫中的一种或多种。
进一步地,所述制品为选自民用口罩、医用口罩、防护手套、防护衣中的一种或多种。
进一步地,所述制品为爆珠口罩。
进一步地,所述制品为选自口香糖、香口丸、爆珠、凝胶糖果、硬糖、饮料中的一种或多种。
本发明还提供了上述制品的制备方法,包括如下步骤:
S1、将所述精油组合物制成精油母粒或精油微胶囊或精油爆珠;
S2、将所述精油母粒或精油微胶囊或精油爆珠与所述制品的其他组分组合,得到所述制品。
进一步地,当所述制品为民用口罩或医用口罩时,所述步骤S2包括将所述精油母粒或精油微胶囊或精油爆珠添加到所述民用口罩或所述医用口罩中。
本发明还提供了一种消毒剂,包括上述精油组合物。
进一步地,所述的消毒剂,包括如下质量分数的原料组分:上述精油组合物5~10%;溶剂65%~70%;增溶剂23%~28%;抗氧化剂0.1%~0.2%。
进一步地,所述溶剂为去离子水;所述增溶剂为质量比为2~4:1的聚山梨醇酯-20与PPG-26丁醇聚醚-26/PEG-40氢化蓖麻油的混合物;所述抗氧化剂为乙二胺四乙酸二钠。
进一步地,上述消毒剂的制备方法包括如下步骤:
(1)将抗氧化剂完全溶解于溶剂中,得预混物A;
(2)将增溶剂与精油组合物混匀,得预混物B;
(3)将预混物B投入预混物A中搅拌均匀,用柠檬酸或柠檬酸钠调节pH值4.0-8.0,得消毒剂。
上述消毒剂用于抑制或杀灭硬表面、多孔表面、纺织品表面、皮肤、粘膜、毛发中的一种或多种上的微生物。
本发明提供的消毒剂是在上述精油组合物的基础上进行稀释制得,气味舒适,对大肠杆菌、金黄色葡萄球菌、白色念珠菌仍具有良好的杀灭效果(杀菌率>99.999%),且皮肤刺激试验结果为轻刺激性,可接触皮肤使用,用于日常的物表或人体等杀菌消毒。
本发明还提供了一种空气消毒剂,包括上述精油组合物。
本发明提供的空气消毒剂由纯植物精油组成,气味适中无刺激,具有良好的空气杀菌消毒效果,对白色葡萄球菌灭杀率(平均值)为≥99.91%,可用于空气消毒清新产品中。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白,以下结合实施例,对本发明进行进一步详细说明。应当理解,此处所描述的具体实施例仅用以解释本发明,并不用于限定本发明。
本发明涉及的香芹酚(CARVACROL)、百里香酚(麝香草酚THYMOL):来自于植物百里香、牛至叶及甘牛至叶等植物提取经纯化处理的挥发油。
本发明涉及的柠檬油:来自于植物柠檬(CITRUS LIMON)果皮提取的挥发油。
本发明涉及的薄荷油(MENTHA HAPLOCALYX OIL):来自于植物唇形科植物薄荷的茎和叶经水蒸气蒸馏,再冷冻,部分脱脑加工得到的挥发油。
本发明涉及的月桂叶油(LAURUS NOBILIS LEAF OIL):来自于樟科植物月桂叶(或果实)提取的挥发油。
本发明涉及的广藿香油(POGOSTEMON CABLIN OIL):是指来自于唇形科植物广藿香叶、茎提取的挥发油。
本发明涉及的天竺葵油:是指来自于牻牛儿苗科植物香叶天竺葵(PELARGONIUMGRAVEOLENS)的花、茎或叶提取的挥发油。
本发明涉及的紫苏油:是指来自于唇形科植物紫苏叶(PERILLAOCYMOIDES LEAF)提取的挥发油。
本发明涉及的丁香(SYZYGIUM AROMATICUM)油:是指来自于木犀科植物丁香花、茎或叶提取的挥发油。
本发明涉及的肉桂(CINNAMOMUM CASSIA)油:是指来自于樟科植物肉桂的树皮、枝、叶经蒸馏所得的挥发油。
本发明涉及的山苍子油又名山鸡椒(LITSEA CUBEBA)果油:是指来自于樟科植物山鸡椒果实提取的挥发油。
实施例1~7
根据下表1中的配方,将各组分在常温常压下混合,搅拌至百里香酚溶解,以制备实施例1-7的精油组合物。
表1实施例精油组合物配方
[注]:上表中的数字代表质量份数。
对比例1~8
为了进一步地说明本发明提供的精油组合物的特性,按下表2中的组分配比,制备对比例1~8精油组合物,其中,对比例1、3、4、5、7、8采用与实施例相同的制备方法,对比例2、6制备方法为将各组分在常温常压下混合。
表2对比例精油组合物配方
[注]:上表中的数字代表质量份数;“-”表示不包含相应组分。
将实施例1~3所得精油组合物与对比例1~4所得精油组合物按表3所示的质量分数的原料配比,与聚山梨醇酯-20、PPG-26丁醇聚醚-26/PEG-40氢化蓖麻油、乙二胺四乙酸二钠及去离子水按照上述消毒剂的制备方法制备成精油稀释液(生产批号分别为2022110301;2022110302;2022110303;2022110304;2022110305;2022110306;2022110307),即消毒剂。
表3消毒剂组分配比
为了验证本发明提供的精油组合物的杀菌特性,将上述包含实施例1~3和对比例1~4精油组合物的消毒剂进行如下试验测试。
试验例1
根据《消毒技术规范》2002年版-2.1.1.7定量杀灭试验和《消毒技术规范》2002年版-2.1.1.9定量杀灭试验,将上述消毒剂进行杀菌性能鉴定测试。
1.大肠杆菌(8099)与金黄色葡萄球菌(ATCC 6538)杀菌试验
试验菌与菌液制备
使用无菌硬水配制,配制的浓度为待测浓度的1.25倍,置20℃±1℃水浴备用。
(1)配制实验用菌悬液,浓度为1×108cfu/ml~5×108cfu/ml。
(2)取消毒试验用无菌大试管,先加入0.5ml试验用菌悬液,再加入0.5ml有机干扰物质,混匀,置20℃±1℃水浴中5min后,用无菌吸管吸取上述浓度消毒液4.0 ml注入其中,迅速混匀并立即记时。
(3)待试验菌与消毒剂相互作用至各预定时间,分别吸取0.5ml试验菌与消毒剂混合液加于4.5ml经灭菌的中和剂中,混匀。
(4)各管试验菌与消毒剂混合液经加中和剂作用10min后,分别吸取1.0ml样液,按活菌培养计数方法测定存活菌数,每管样液接种2个平皿即可。如平板上生长的菌落数较多时,可进行系列10倍稀释后,再进行活菌培养计数。
(5)同时用稀释液代替消毒液,进行平行试验,作为阳性对照。
(6)所有试验样本均在37℃温箱中培养,对细菌繁殖体培养48h观察最终结果;对细菌芽孢需培养72h观察最终结果。
试验重复3次,计算各组的活菌浓度(cfu/ml),并换算为对数值(N),然后按下式计算杀灭对数值:
杀灭对数值(KL)=对照组平均活菌浓度的对数值(No)-试验组活菌浓度对数值(Nx)
计算杀灭对数值时,取小数点后两位值,可以进行数字修约。如果消毒试验组消毒处理后平均生产菌落数,小于等于1时,其杀灭对数值,即大于等于试验前对照组平均活菌浓度的对数值。
杀菌率计算:试验重复3次,计算各组的活菌浓度(cfu/ml),并换算为对数值(N),然后按下式计算杀灭对数值。
式中:X为杀菌率,%;NC为对照样品平均菌落数,cfu/片;NS为被试样品平均菌落数,cfu/片。
2.白色念珠菌(ATCC 10231)杀菌试验
(1)磷酸盐缓冲液(PBS,0.03mol/L,pH7.2)。
(2)消毒剂稀释用硬水:见附录A。
(3)有机干扰物质:见附录A。
(4)刻度吸管(0.1ml、1.0ml、5.0ml)。
(5)恒温水浴箱。
(6)喷雾装置(用于喷雾消毒试验)。
(7)电动混合器。
(8)计时装置。
真菌悬液制备
(1)白色念珠菌悬液的制备
1)取冻干菌种管,以无菌操作打开,用毛细吸管吸加适量沙堡液体培养基于管中,轻柔吹吸数次,使菌种融化分散。取含5.0ml~10.0ml沙堡液体培养基试管,滴入少许菌种悬液,置37℃培养18h~24h。用接种环取第1代培养的菌悬液,划线接种于沙堡琼脂培养基平板上,于37℃培养18h~24h。挑取上述第2代培养物中典型菌落,接种于沙堡琼脂斜面,于37℃培养18h~24h,即为第3代培养物。将其密封后在4℃保存,时间不得超过6周。
2)试验时,取第3代斜面培养物在沙堡琼脂斜面上连续传代,方法与第3代相同。取第5代或6代的沙堡琼脂培养基斜面新鲜培养物(18h~24h),用5.0ml吸管吸取3.0ml~5.0ml稀释液加入斜面试管内,反复吹吸,洗下菌苔。随后,用5.0ml吸管将洗液移至另一无菌试管中,用电动混合器混合20s,或在手掌上振敲80次,以使白色念珠菌菌悬浮均匀。
3)悬液杀菌试验时,实验用菌悬液的含菌量为1×107cfu/ml~5×107cfu/ml;制备菌片。
4)菌悬液保存在4℃冰箱内备用。
试验分组
试验分为下列各组:
(1)试验组,消毒剂浓度(精油稀释液原液)与作用时间2min,对白色念珠菌的杀灭能力进行测定。
(2)阳性对照组,以硬水代替消毒剂溶液,按规定程序进行试验。所得结果代表试验体系中所含试验菌的初始浓度,并以其计算消毒因子对试验菌的杀灭对数值。
(3)阴性对照组,观察同次试验用相关溶液和培养基有无污染。
(4)悬液定量杀菌试验,在37℃培养箱中培养48h观察最终结果。
试验重复3次,计算各组的活菌浓度(cfu/ml),并换算为对数值(N),然后按下式计算杀灭对数值:
杀灭对数值(KL)=对照组平均活菌浓度的对数值(No)-试验组活菌浓度对数值(Nx)
计算杀灭对数值时,取小数点后两位值,可以进行数字修约。如果消毒试验组消毒处理后平均生产菌落数,小于等于1时,其杀灭对数值,即大于等于试验前对照组平均活菌浓度的对数值。
杀菌率计算:试验重复3次,计算各组的活菌浓度(cfu/ml),并换算为对数值(N),然后按下式计算杀灭对数值。
式中:X为杀菌率,%;NC为对照样品平均菌落数,cfu/片;NS为被试样品平均菌落数,cfu/片。
作用浓度、作用时间、试验条件相同,对某一菌种,不同消毒剂间杀菌效能比较,式中:Y为杀菌效能倍数;N为对照样品平均菌落数,A消毒剂平均菌落数,cfu/片;B消毒剂平均菌落数,cfu/片。
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实施例1~3和对比例1~4对应的不同批号的消毒剂的杀菌试验结果如表4所示。
表4
由表中数据可知,本发明提供的精油组合物对大肠杆菌、金黄色葡萄球菌、白色念珠菌具有良好的杀灭效果。
表格中体现的数值,杀菌率为99.999%、99.99%、99.9%看似差别微小的数值,反映到消毒原料的杀菌能力上却有10倍、100倍的差距。在实验室按照《消毒技术规范》2002年版规定方法做杀菌效果鉴定实验时,当杀灭对数值为3时,对应杀菌率为99.9%;对数值为4时,对应杀菌率为99.99%;对数值为5时,对应杀菌率为99.999%。一般草本抑/抗菌原料相对温和,对微生物的杀灭对数值很难达到≥3(杀菌率≥99.9%),因此本项工作在筛选多种精油复配,经协同增效后对多种微生物的杀灭对数值≥4(杀菌率≥99.99%),甚至于杀灭对数值≥5(杀菌率≥99.999%),是非常重要及难得的发现。
试验例2
根据《消毒技术规范》2002年版,第二部分2.3.3,对上述包含实施例1~3和对比例1~4精油组合物的消毒剂进行一次完整皮肤刺激试验。
试验前24h,将家兔背部脊柱两侧的毛剃掉。去毛范围,左、右各约3cm×3cm。取0.5mL受试物涂抹在一侧皮肤上,然后用一层无刺激塑料膜覆盖,再用无刺激胶布固定。另一侧皮肤作为空白对照。采用封闭试验,敷用时间为4h。实验结束后,用温水清除残留受试物。
于清除受试物后的1h、24h和48h分别观察受试部位皮肤反应结果,按皮肤刺激反应评分表进行皮肤反应评分。根据1h、24h和48h各观察点最高积分均值,按皮肤刺激强度分级标准表判定皮肤刺激强度。实施例1~3与对比例1~4对应的消毒剂的皮肤刺激性测试结果如表5所示。
表5皮肤刺激性测试结果
由以上数据可见,本发明提供的精油组合物,在本次试验条件下,对新西兰兔一次完整皮肤刺激试验结果为轻刺激性或无刺激性。
综上,通过实施例1~3与对比例1~4试验结果的对比可知,本发明通过对多种精油成分进行复配和配比调控而得到精油组合物。本发明将香芹酚、百里香酚、柠檬油、薄荷油、月桂叶油、广藿香油、天竺葵油、紫苏油与肉桂油、丁香油、山苍子油复配具有协同作用改善了精油组合物的杀菌功效和皮肤刺激性,同时通过添加桂花油、柠檬草油作为调香成分进一步地优化了精油组合物的刺激性。本发明提供的精油组合物能够应用于制备抗微生物制品中,如消毒剂。
同时,为了验证本发明精油组合物的空气杀菌消毒效果,按本发明将实施例4~6和对比例5~8的配方和制备方法制备精油组合物用作空气消毒剂(生产批号分别为2022110401、2022110402、2022110403、2022110404、2022110405、2022110406和2022110407)。将空气消毒剂进行如下试验测试。
试验例3
参照《消毒技术规范》2002年版2.1.3,将上述空气消毒剂进行空气消毒效果实验室试验。
1.器材
试验样品:空气消毒剂,生产批号2022110401、2022110402、2022110403、2022110404、2022110405、2022110406和2022110407。
试验菌株:白色葡萄球菌8032菌株代数为第4代,菌株来源:广东省微生物菌种保藏中心。
中和剂成分及浓度:3%吐温-80、0.5%硫代硫酸钠、0.5%L-组氨酸、0.5%蛋白胨、0.85%氯化钠、1.43%卵磷脂、0.1%半胱氨酸的PBS溶液。
培养基名称及批号:含中和剂的营养琼脂培养基(批号:20220606)。
气雾室的体积:lm3。
使用仪器:生化培养箱(编号:OFM-B-S051),水浴锅(编号:OFM-B-K038),液体撞击式微生物气溶胶采样器(编号:OFM-B-S041)、生物安全柜(编号:OFM-B-S028)。
2.方法
检测环境:温度23.8℃,相对湿度62%。
方法简述:在1m3的试验室内,边喷雾边用风扇搅拌,喷雾完毕,风扇继续搅拌5min,然后静置5min。气雾室内空气中各阳性对照菌数达5.0×104cfu/m3~5.0x106cfu/m3。用液体撞击式微生物气溶胶采样器对试验组和对照组气雾室进行消毒前采样,以11L/min的流量进行采样,采样液的体积为20mL,试验组与对照组的采样时间均为2min。将样液加入雾化器中,通电开机雾化10mL样液到气雾室空气中,关闭房间门,消毒作用1h后,用含中和剂的采样液以相同流量对消毒后气雾室进行采样,试验组与对照组的采样时间均为2min。将采集后的平皿置37℃培养箱内培养48h后观察结果。试验重复3次。
3.结果
在环境温度为23.8℃,相对湿度62%的条件下,将样液加入委托方提供的雾化器中,通电开机雾化10mL样液到1m3的气雾室内作用1h。各批空气消毒剂对白色葡萄球菌的杀菌率结果(3次试验结果均不小于表中数据)见表6。
表6
由以上结果可知,将本发明实施例制备的的精油组合物用作空气消毒剂加入雾化器中,通电开机雾化10mL样液到1m3气雾室内作用1h,试验重复3次,空气中白色葡萄球菌杀菌率的检测结果介于99.91%~99.98%之间,说明本发明实施例提供的精油组合物对空气中白色葡萄球菌具有良好的灭杀效果。
综上,通过实施例4~6与对比例5~8试验结果的对比可知,本发明通过对多种精油成分进行复配和配比调控得到的精油组合物还对空气中的白色葡萄球菌具有良好的灭杀效果。本发明提供的精油组合物能够应用于制备抑制或杀灭空气中的微生物制品中。
以上所述仅为本发明的较佳实施例而已,并不用以限制本发明,凡在本发明的精神和原则之内所作的任何修改、等同替换或改进等,均应包含在本发明的保护范围之内。
Claims (29)
1.一种精油组合物,其特征在于,包括如下质量份数的组分:香芹酚3~7份;百里香酚0.08~0.4份;柠檬油0.076~1.45份;薄荷油0.08~1.24份;月桂叶油0.24~0.45份;广藿香油0.01~0.42份;天竺葵油0.004~0.24份;紫苏油0.04~0.4份;肉桂油35~60份;丁香油0.08~22份和山苍子油0.08~17份。
2.如权利要求1所述的精油组合物,其特征在于,包括如下质量份数的组分:香芹酚4.5~6.8份;百里香酚0.2~0.4份;柠檬油0.95~1.45份;薄荷油0.7~1.24份;月桂叶油0.3~0.45份;广藿香油0.01~0.02份;天竺葵油0.12~0.24份;紫苏油0.25~0.4份;肉桂油50~55份;丁香油0.08~3.2份和山苍子油0.08~1份。
3.如权利要求1所述的精油组合物,其特征在于,包括如下质量份数的组分:香芹酚3~5份;百里香酚0.08~0.12份;柠檬油0.08~0.12份;薄荷油0.08~0.12份;月桂叶油0.24~0.36份;广藿香油0.2~0.4份;天竺葵油0.004~0.008份;紫苏油0.04~0.08份;肉桂油35~45份;丁香油16~22份和山苍子油12~17份。
4.如权利要求2所述的精油组合物,其特征在于,包括如下质量份数的组分:香芹酚5.673份;百里香酚0.276份;柠檬油1.208份;薄荷油1.035份;月桂叶油0.345份;广藿香油0.017份;天竺葵油0.173份;紫苏油0.328份;肉桂油55份;丁香油0.1份和山苍子油0.1份。
5.如权利要求2所述的精油组合物,其特征在于,包括如下质量份数的组分:香芹酚4.5份;百里香酚0.39份;柠檬油0.95份;薄荷油0.75份;月桂叶油0.45份;广藿香油0.02份;天竺葵油0.24份;紫苏油0.4份;肉桂油52份;丁香油3份和山苍子油0.5份。
6.如权利要求3所述的精油组合物,其特征在于,包括如下质量份数的组分:香芹酚3.9份;百里香酚0.1份;柠檬油0.095份;薄荷油0.1份;月桂叶油0.3份;广藿香油0.35份;天竺葵油0.005份;紫苏油0.05份;肉桂油40份;丁香油20份和山苍子油15份。
7.如权利要求3所述的精油组合物,其特征在于,包括如下质量份数的组分:香芹酚3份;百里香酚0.12份;柠檬油0.1份;薄荷油0.12份;月桂叶油0.25份;广藿香油0.2份;天竺葵油0.008份;紫苏油0.07份;肉桂油45份;丁香油17份和山苍子油13份。
8.如权利要求1至7任一项所述的精油组合物,其特征在于,还包括如下质量份数的组分:桂花油5~12份和柠檬草油2~12份。
9.权利要求1至7任一项所述的精油组合物的制备方法,其特征在于,包括如下步骤:
将各组分在常温常压下混合,搅拌至百里香酚溶解,即得。
10.权利要求1至7任一项所述的精油组合物在抗微生物中的应用。
11.如权利要求10所述的应用,其特征在于,所述微生物选自细菌、真菌及其组合。
12.如权利要求11所述的应用,其特征在于,所述细菌为革兰氏阴性菌或革兰氏阳性菌中的一种或多种。
13.如权利要求12所述的应用,其特征在于,所述革兰氏阴性菌包括卡他球菌、大肠杆菌、铜绿假单胞菌、痢疾杆菌中的一种或多种;所述革兰氏阳性菌包括肺炎链球菌、白色葡萄球菌、金黄色葡萄球菌、痤疮丙酸杆菌、表皮葡萄球菌中的一种或多种;所述真菌包括霉菌、酵母菌、白色念珠菌、马拉色菌中的一种或多种。
14.包含权利要求1至7任一项所述的精油组合物的制品。
15.如权利要求14所述的制品,其特征在于,所述制品包括用于抑制或杀灭硬表面、多孔表面、纺织品表面、皮肤、粘膜、毛发中的一种或多种上的微生物的制品或用于抑制或杀灭空气中的微生物的制品。
16.如权利要求15所述的制品,其特征在于,所述制品为选自药品、消毒产品、防护用品、保健食品、食品、膳食补充剂、日化产品、纺织品中的一种或多种。
17.如权利要求16所述的制品,其特征在于,所述制品为化妆品、个人清洁护理用品或日常洗涤用品。
18.如权利要求16所述的制品,其特征在于,所述制品为选自爆珠、湿巾、织物除菌液、肥皂、香皂、洗衣液、洗洁精、祛痘膏、护手霜、空气清新剂、香薰、香水、牙膏、口腔喷雾、鼻吸棒、洗手液、洗发水、护发素、沐浴液、空气消毒凝胶、空气消毒剂、油污清洁剂、皮肤消毒剂、皮肤抑菌喷雾中的一种或多种。
19.如权利要求16所述的制品,其特征在于,所述制品为选自内衣、内裤、卫生巾、床单、袜子、鞋垫中的一种或多种。
20.如权利要求16所述的制品,其特征在于,所述制品为选自民用口罩、医用口罩、防护手套、防护衣中的一种或多种。
21.如权利要求20所述的制品,其特征在于,所述制品为爆珠口罩。
22.如权利要求16所述的制品,其特征在于,所述制品为选自口香糖、香口丸、爆珠、凝胶糖果、硬糖、饮料中的一种或多种。
23.权利要求14至22任一项所述的制品的制备方法,其特征在于,包括如下步骤:
S1、将所述精油组合物制成精油母粒或精油微胶囊或精油爆珠;
S2、将所述精油母粒或精油微胶囊或精油爆珠与所述制品的其他组分组合,按照常规方法制得所述制品。
24.如权利要求23所述的制备方法,其特征在于,所述制品为民用口罩或医用口罩,所述步骤S2,包括将所述精油母粒或精油微胶囊或精油爆珠添加到所述民用口罩或所述医用口罩中。
25.一种消毒剂,其特征在于,包括权利要求1、2、4或5任一项所述的精油组合物。
26.如权利要求25所述的消毒剂,其特征在于,包括如下质量分数的原料组分:所述精油组合物5~10%;溶剂65%~70%;增溶剂23%~28%;抗氧化剂0.1%~0.2%。
27.如权利要求26所述的消毒剂,其特征在于,所述溶剂为去离子水;所述增溶剂为质量比为2~4:1的聚山梨醇酯-20与PPG-26丁醇聚醚-26/PEG-40氢化蓖麻油的混合物;所述抗氧化剂为乙二胺四乙酸二钠。
28.如权利要求27所述的消毒剂,其特征在于,所述消毒剂的制备方法包括如下步骤:
(1)将抗氧化剂完全溶解于溶剂中,得预混物A;
(2)将增溶剂与精油组合物混匀,得预混物B;
(3)将预混物B投入预混物A中搅拌均匀,用柠檬酸或柠檬酸钠调节pH值3.0-10.0,得消毒剂。
29.一种空气消毒剂,其特征在于,包括权利要求1、3、6或7任一项所述的精油组合物。
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