CN116999361A - Anti-inflammatory acne-removing mask essence, preparation method and application thereof, and anti-inflammatory acne-removing mask - Google Patents
Anti-inflammatory acne-removing mask essence, preparation method and application thereof, and anti-inflammatory acne-removing mask Download PDFInfo
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- CN116999361A CN116999361A CN202311049511.8A CN202311049511A CN116999361A CN 116999361 A CN116999361 A CN 116999361A CN 202311049511 A CN202311049511 A CN 202311049511A CN 116999361 A CN116999361 A CN 116999361A
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- extract
- mask essence
- acne
- removing mask
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Abstract
The invention belongs to the technical field of daily chemical skin care products, and particularly relates to an anti-inflammatory acne-removing mask essence, a preparation method and application thereof, and an anti-inflammatory acne-removing mask. The anti-inflammatory acne-removing mask essence provided by the invention comprises 4-10 parts of kuh-seng root extract, 2-6 parts of honeysuckle extract, 2-6 parts of dandelion extract, 1-5 parts of wild chrysanthemum extract, 1-3 parts of paeonia root extract, 1-3 parts of butanediol, 1-3 parts of glycerol, 0.8-2 parts of xanthan gum, 0.5-1.6 parts of nicotinamide, 0.8-1.5 parts of betaine, 0.6-1 part of witch hazel water, 0.5-3 parts of panthenol, 0.5-2 parts of 1, 2-hexanediol, 0.5-1.5 parts of beta-glucan, 0.3-1.2 parts of p-hydroxyacetophenone and the like. The mask essence provided by the invention is prepared from various natural traditional Chinese medicine components according to the principles of monarch, minister, assistant and guide, and can play a role in diminishing inflammation and removing acnes on the basis of antioxidation.
Description
Technical Field
The invention belongs to the technical field of daily chemical skin care products, and particularly relates to an anti-inflammatory acne-removing mask essence, a preparation method and application thereof, and an anti-inflammatory acne-removing mask.
Background
The skin is the largest organ of the human body, is in direct contact with the external environment, and can rapidly respond to a series of changes of the body caused by internal and external factors, such as roughness, dryness, relaxation, wrinkle increase and the like. In the process of organism change, reactive Oxygen Species (ROS) are generated, and excessive Reactive Oxygen Species (ROS) damage the organism balance, so that oxidative stress is caused, and oxidative damage is caused. Can increase inflammation in vivo, activate related signal channels, cause apoptosis, reduce synthesis of various elastin, and cause skin diseases such as aging, photoaging, acne, etc. of different degrees in vitro.
A large number of experiments prove that the anti-oxidation product can be used for removing free radicals and excessive oxides in vivo, inhibiting propionibacterium acnes related to acne, and achieving the effects of diminishing inflammation, resisting acne and the like to different degrees. The products for acne removal on the market at present are various, such as oral administration, external use and the like, and the acne removal mask mostly contains chemical components such as salicylic acid, quaternary ammonium salt-73 (Pi Aoning) and the like, so that adverse phenomena such as skin allergy and the like are easy to cause after long-term use.
Disclosure of Invention
The invention aims to provide an anti-inflammatory acne-removing mask essence, a preparation method and application thereof, and an anti-inflammatory acne-removing mask.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides an anti-inflammatory acne-removing mask essence, which comprises the following components in parts by weight: 4 to 10 parts of kuh-seng root extract, 2 to 6 parts of honeysuckle extract, 2 to 6 parts of dandelion extract, 1 to 5 parts of wild chrysanthemum extract, 1 to 3 parts of paeonia root extract, 1 to 3 parts of butanediol, 1 to 3 parts of glycerin, 0.8 to 2 parts of xanthan gum, 0.5 to 1.6 parts of nicotinamide, 0.8 to 1.5 parts of betaine, 0.6 to 1 part of witch hazel water, 0.5 to 3 parts of panthenol, 0.5 to 2 parts of 1, 2-hexanediol, 0.5 to 1.5 parts of beta-glucan, 0.3 to 1.2 parts of p-hydroxyacetophenone, 0.1 to 0.5 part of hydrolyzed sclerotium gum, 0.1 to 0.3 part of sodium hyaluronate, 0.1 to 0.15 part of ethylene diamine tetraacetic acid, 0.08 to 0.15 part of dipotassium glycyrrhizinate and 49 to 84 parts of water.
Preferably, the preparation method of the kuh-seng root extract, the honeysuckle extract, the dandelion extract, the wild chrysanthemum extract or the paeonia lactiflora root extract independently comprises the following steps of:
respectively extracting radix Sophorae Flavescentis, flos Lonicerae, herba Taraxaci, flos Chrysanthemi Indici or radix Paeoniae to obtain radix Sophorae Flavescentis extractive solution, flos Lonicerae extractive solution, herba Taraxaci extractive solution, flos Chrysanthemi Indici extractive solution or radix Paeoniae extractive solution.
Preferably, the extraction method is decoction; the decocted solvent is water, the mass ratio of the feed liquid is 1:5-10, and the time is 1.5-2 h.
Preferably, when the kuh-seng root extract is prepared, the number of times of extraction is 1 to 3;
when the honeysuckle extract, the dandelion extract, the wild chrysanthemum extract or the paeonia lactiflora extract are prepared, the extraction times are 1-2 times.
Preferably, the extraction further comprises sequentially filtering and concentrating;
the filtering comprises centrifugal filtering;
the concentration is evaporation concentration; the solute mass concentration of the extract obtained after concentration is 0.5-2 g/mL.
Preferably, when preparing the kuh-seng root extract, the method further comprises alcohol precipitation and impurity removal;
the alcohol used for removing impurities by alcohol precipitation is ethanol water solution; the volume concentration of the ethanol in the ethanol water solution is 50-60%; the mass ratio of the ethanol aqueous solution to the extracting solution is 1-3:1.
The invention also provides a preparation method of the anti-inflammatory acne-removing mask essence, which is characterized by comprising the following steps of:
mixing betaine, hydrolyzed sclerotium rolfsii, allantoin, hydrolyzed sodium hyaluronate, disodium ethylenediamine tetraacetate, dipotassium glycyrrhizinate and part of water for the first time to obtain a first mixture;
second mixing the first mixture, xanthan gum, nicotinamide and p-hydroxyacetophenone to obtain a second mixture;
thirdly mixing the second mixture, butanediol, glycerol, hamamelis virginiana water, panthenol, 1, 2-hexanediol, beta-glucan and the rest water to obtain a third mixture;
and fourthly, mixing the third mixture, the kuh-seng root extract, the honeysuckle extract, the dandelion extract, the wild chrysanthemum extract and the paeonia lactiflora root extract to obtain the anti-inflammation acne-removing mask essence.
Preferably, the temperature of the first mixing is 60-70 ℃;
the temperature of the second mixing is 50-60 ℃;
the temperature of the third mixing is 40-50 ℃;
the fourth mixing temperature is 25-40 ℃.
The invention also provides the anti-inflammatory acne-removing mask essence prepared by the technical scheme or the application of the anti-inflammatory acne-removing mask essence prepared by the preparation method in skin care products.
The invention also provides an anti-inflammatory acne-removing mask which comprises mask paper and mask essence;
the mask essence is the anti-inflammatory acne-removing mask essence prepared by the technical scheme or the preparation method.
The invention provides an anti-inflammatory acne-removing mask essence, which comprises the following components in parts by weight: 4 to 10 parts of kuh-seng root extract, 2 to 6 parts of honeysuckle extract, 2 to 6 parts of dandelion extract, 1 to 5 parts of wild chrysanthemum extract, 1 to 3 parts of paeonia root extract, 1 to 3 parts of butanediol, 1 to 3 parts of glycerin, 0.8 to 2 parts of xanthan gum, 0.5 to 1.6 parts of nicotinamide, 0.8 to 1.5 parts of betaine, 0.6 to 1 part of witch hazel water, 0.5 to 3 parts of panthenol, 0.5 to 2 parts of 1, 2-hexanediol, 0.5 to 1.5 parts of beta-glucan, 0.3 to 1.2 parts of p-hydroxyacetophenone, 0.1 to 0.5 part of hydrolyzed sclerotium gum, 0.1 to 0.3 part of sodium hyaluronate, 0.1 to 0.15 part of ethylene diamine tetraacetic acid, 0.08 to 0.15 part of dipotassium glycyrrhizinate and 49 to 84 parts of water. The mask essence provided by the invention is added with various plant extract components, including dandelion extract, kuh-seng root extract, honeysuckle extract, paeonia lactiflora root extract and wild chrysanthemum extract, wherein the kuh-seng is taken as a monarch, so that the mask essence can clear heat and dry dampness, is favorable for damp-heat symptoms such as skin itch and the like, can accelerate metabolism of damaged skin, inhibits various skin bacteria and fungi, and has the effects of diminishing inflammation and removing acnes; the ministerial drugs are dandelion, exert the effects of clearing heat and detoxicating, inducing diuresis and relieving swelling, and resolving masses, and are favorable for relieving the manifestations of heat syndromes such as red swelling and pain; flos Chrysanthemi and flos Lonicerae are used as adjuvants for dispelling pathogenic wind and heat, detumescence and detoxification, and auxiliary and ministerial drugs exert effects of clearing heat and eliminating dampness; paeonia lactiflora is used for clearing heat and detoxicating, contains paeonol with antibacterial and antioxidant effects, can inhibit generation of superoxide radicals in cells, improve capability of cells for defending free radicals, and can also harmonize various medicines to make the extracts act synergistically, so as to have effects of clearing heat and eliminating dampness, cooling blood and moistening dryness. The mask essence provided by the invention is prepared from various natural traditional Chinese medicine components according to the principles of monarch, minister, assistant and guide, and can play a role in diminishing inflammation and removing acnes on the basis of antioxidation.
In addition, the mask essence provided by the invention is compounded with the multiple plant extract components and the multiple moisturizing agent, has the effects of moisturizing, moisturizing and skin care, does not contain essence or hormone, uses a mild and natural preservative system, and is mild in component and not stimulated.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions of the prior art, the drawings that are needed in the embodiments will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a comparison of skin conditions of a person 1 before and after using the anti-inflammatory acne mask provided in example 2;
fig. 2 is a comparison of skin conditions of a person 2 before and after using the anti-inflammatory and anti-acne mask provided in example 2;
fig. 3 is a comparison of skin conditions of a test person 3 before and after using the anti-inflammatory and anti-acne mask provided in example 2.
Detailed Description
The invention provides an anti-inflammatory acne-removing mask essence, which comprises the following components in parts by weight: 4 to 10 parts of kuh-seng root extract, 2 to 6 parts of honeysuckle extract, 2 to 6 parts of dandelion extract, 1 to 5 parts of wild chrysanthemum extract, 1 to 3 parts of paeonia root extract, 1 to 3 parts of butanediol, 1 to 3 parts of glycerin, 0.8 to 2 parts of xanthan gum, 0.5 to 1.6 parts of nicotinamide, 0.8 to 1.5 parts of betaine, 0.6 to 1 part of witch hazel water, 0.5 to 3 parts of panthenol, 0.5 to 2 parts of 1, 2-hexanediol, 0.5 to 1.5 parts of beta-glucan, 0.3 to 1.2 parts of p-hydroxyacetophenone, 0.1 to 0.5 part of hydrolyzed sclerotium gum, 0.1 to 0.3 part of sodium hyaluronate, 0.1 to 0.15 part of ethylene diamine tetraacetic acid, 0.08 to 0.15 part of dipotassium glycyrrhizinate and 49 to 84 parts of water.
In the present invention, all raw material components are commercially available products well known to those skilled in the art unless specified otherwise.
The anti-inflammatory acne-removing mask essence provided by the invention comprises 4-10 parts by weight of kuh-seng root extract, preferably 5-9 parts by weight, and more preferably 6-8 parts by weight.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 2-6 parts of honeysuckle extract, preferably 3-6 parts, and more preferably 3-5 parts.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 2-6 parts of dandelion extract, preferably 3-6 parts, and more preferably 3-5 parts.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 1-5 parts of wild chrysanthemum extract, preferably 2-5 parts, and more preferably 2-4 parts.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 1-3 parts of the paeonia lactiflora root extract, and preferably 1-2 parts.
In the invention, the preparation method of the kuh-seng root extract, the honeysuckle extract, the dandelion extract, the wild chrysanthemum extract or the paeonia lactiflora root extract independently comprises the following steps of:
respectively extracting radix Sophorae Flavescentis, flos Lonicerae, herba Taraxaci, flos Chrysanthemi Indici or radix Paeoniae to obtain radix Sophorae Flavescentis extractive solution, flos Lonicerae extractive solution, herba Taraxaci extractive solution, flos Chrysanthemi Indici extractive solution or radix Paeoniae extractive solution.
In the present invention, the extraction mode is preferably decoction; the solvent for decoction is preferably water; the water is preferably purified water; the mass ratio of the decocted feed liquid is preferably 1:5-10, more preferably 1:5-8; the time is preferably 1.5 to 2 hours, more preferably 2 hours.
In the present invention, the extraction is preferably preceded by soaking; the soaking time is preferably 1 to 2 hours, more preferably 1.5 to 2 hours.
In the present invention, when the kuh-seng root extract is prepared, the number of times of the extraction is preferably 1 to 3, more preferably 2.
In the present invention, when the honeysuckle extract, dandelion extract, wild chrysanthemum extract or paeonia lactiflora extract is prepared, the number of times of the extraction is preferably 1 to 2, more preferably 1.
In the present invention, the extraction is preferably followed by filtration and concentration in sequence; the filtration preferably comprises sequentially sieving and centrifuging; the number of the screen meshes of the screen is preferably 140 to 200 meshes, more preferably 200 meshes; the centrifugal filtration process is not particularly limited, and a mode well known to a person skilled in the art is adopted; the concentration is preferably evaporative concentration; the solute mass concentration of the extract obtained after concentration is preferably 0.5 to 2g/mL, more preferably 1 to 2g/mL.
In the present invention, when preparing the kuh-seng root extract, the concentration is preferably preceded by combining the extracts.
In the present invention, when preparing the kuh-seng root extract, it is also preferable to include alcohol precipitation to remove impurities; the alcohol precipitation impurity removal is preferably performed after concentration; the alcohol used for removing impurities by alcohol precipitation is preferably ethanol water solution; the ethanol volume concentration of the ethanol aqueous solution is preferably 50 to 60%, more preferably 55 to 60%; the mass ratio of the ethanol aqueous solution to the extracting solution is preferably 1-3:1, more preferably 2:1.
The indexes of the traditional Chinese medicine raw materials used by the invention all accord with the catalogue of the pharmacopoeia of the people's republic of China of 2020 edition, wherein the main pharmacological activities of the traditional Chinese medicines are as follows: the kuh-seng has good relieving effect on skin itch, can inhibit various skin bacteria and fungi, has the effects of diminishing inflammation, removing acne, removing cold and bitter taste, clearing heat and drying dampness, killing parasites and relieving itching, eliminating damp-heat of lower jiao, and has the effects of treating skin itch, removing spots, accelerating metabolism of damaged skin and beautifying and protecting skin; the honeysuckle can maintain the water-oil balance of skin, prevent the accumulation of metabolites, has bitter taste and cold property, has the functions of clearing heat and detoxicating, and can disperse wind and heat; the dandelion has the effects of clearing heat and detoxicating, detumescence and resolving hard mass, promoting urination and treating stranguria, and has broad-spectrum antibacterial effect; the wild chrysanthemum flower is rich in glycosides, alkaloids, amino acids and microelements, and has the effects of promoting skin blood circulation, nourishing skin, tranquilizing mind and improving eyesight; paeonia lactiflora contains abundant paeonol, has antibacterial and antioxidant effects, and can inhibit the generation of superoxide radical in cells, improve the ability of cells to defend free radicals, and the oleanolic acid component can regulate the balance of immune system, thereby inhibiting inflammation.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 1-3 parts of butanediol, and preferably 2-3 parts.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 1-3 parts of glycerin, preferably 1.5-3 parts.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 0.8-2 parts of xanthan gum, and preferably 1-2 parts of xanthan gum.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 0.5-1.6 parts of nicotinamide, and preferably 0.8-1.5 parts of nicotinamide.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 0.8-1.5 parts of betaine, and preferably 0.8-1 part.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 0.6-1 part of Hamamelis virginiana water, preferably 0.8-1 part.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 0.5-3 parts of panthenol, preferably 1-3 parts, and more preferably 2-3 parts.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 0.5-2 parts of 1, 2-hexanediol, preferably 0.8-1.8 parts, and more preferably 0.8-1.5 parts.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 0.5-1.5 parts of beta-glucan, preferably 0.8-1.2 parts, and more preferably 0.8-1 part.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 0.3-1.2 parts of p-hydroxyacetophenone, and preferably 0.5-1 part.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 0.1-0.5 part of hydrolyzed sclerotium rolfsii, and preferably 0.1-0.4 part.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 0.1-0.5 part of allantoin, preferably 0.3-0.5 part.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 0.1-0.3 part of hydrolyzed sodium hyaluronate, and preferably 0.15-0.2 part.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 0.1-0.15 part of disodium ethylenediamine tetraacetate, and preferably 0.15 part.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 0.08-0.15 part of dipotassium glycyrrhizinate, preferably 0.08-0.1 part.
Based on the mass parts of the kuh-seng root extract, the anti-inflammatory acne-removing mask essence provided by the invention comprises 49-84 parts of water, preferably 50-80 parts, more preferably 60-70 parts; the water is preferably deionized water.
The mask essence provided by the invention is added with various plant extract components, including dandelion extract, kuh-seng root extract, honeysuckle extract, paeonia lactiflora root extract and wild chrysanthemum extract, wherein the kuh-seng is taken as a monarch, so that the mask essence can clear heat and dry dampness, is favorable for damp-heat symptoms such as skin itch and the like, can accelerate metabolism of damaged skin, inhibits various skin bacteria and fungi, and has the effects of diminishing inflammation and removing acnes; the ministerial drugs are dandelion, exert the effects of clearing heat and detoxicating, inducing diuresis and relieving swelling, and resolving masses, and are favorable for relieving the manifestations of heat syndromes such as red swelling and pain; flos Chrysanthemi and flos Lonicerae are used as adjuvants for dispelling pathogenic wind and heat, detumescence and detoxification, and auxiliary and ministerial drugs exert effects of clearing heat and eliminating dampness; paeonia lactiflora is used for clearing heat and detoxicating, contains paeonol with antibacterial and antioxidant effects, can inhibit generation of superoxide radicals in cells, improve capability of cells for defending free radicals, and can also harmonize various medicines to make the extracts act synergistically, so as to have effects of clearing heat and eliminating dampness, cooling blood and moistening dryness. The mask essence provided by the invention is prepared from various natural traditional Chinese medicine components according to the principles of monarch, minister, assistant and guide, and can play a role in diminishing inflammation and removing acnes on the basis of antioxidation. In addition, the mask essence provided by the invention is compounded with the multiple plant extract components and the multiple moisturizing agent, has the effects of moisturizing, moisturizing and skin care, does not contain essence or hormone, uses a mild and natural preservative system, and is mild in component and not stimulated.
The invention also provides a preparation method of the anti-inflammatory acne-removing mask essence, which is characterized by comprising the following steps of:
mixing betaine, hydrolyzed sclerotium rolfsii, allantoin, hydrolyzed sodium hyaluronate, disodium ethylenediamine tetraacetate, dipotassium glycyrrhizinate and part of water for the first time to obtain a first mixture;
second mixing the first mixture, xanthan gum, nicotinamide and p-hydroxyacetophenone to obtain a second mixture;
thirdly mixing the second mixture, butanediol, glycerol, hamamelis virginiana water, panthenol, 1, 2-hexanediol, beta-glucan and the rest water to obtain a third mixture;
and fourthly, mixing the third mixture, the kuh-seng root extract, the honeysuckle extract, the dandelion extract, the wild chrysanthemum extract and the paeonia lactiflora root extract to obtain the anti-inflammation acne-removing mask essence.
The method comprises the step of first mixing betaine, hydrolyzed sclerotium rolfsii, allantoin, hydrolyzed sodium hyaluronate, disodium ethylenediamine tetraacetate, dipotassium glycyrrhizinate and part of water to obtain a first mixture.
In the present invention, the temperature of the first mixing is preferably 60 to 70 ℃, more preferably 60 to 65 ℃; the first mixing means is preferably stirring; the stirring process is not particularly limited in the present invention, and the first mixture may be sufficiently dissolved in a manner well known to those skilled in the art.
After the first mixture is obtained, the first mixture, xanthan gum, nicotinamide and p-hydroxyacetophenone are mixed for the second time to obtain a second mixture.
In the present invention, the temperature of the second mixing is preferably 50 to 60 ℃, more preferably 50 to 55 ℃; the second mixing means is preferably stirring; the stirring process is not particularly limited in the present invention, and the second mixture may be uniformly dispersed in a manner well known to those skilled in the art.
After the second mixture is obtained, the second mixture, butanediol, glycerol, hamamelis mollis water, panthenol, 1, 2-hexanediol, beta-glucan and the rest water are mixed for the third time to obtain a third mixture.
In the present invention, the mass ratio of the partial water to the residual water is preferably 4 to 9:1 to 6, more preferably 5 to 8:2 to 5, and most preferably 7:3.
In the present invention, the temperature of the third mixing is preferably 40 to 50 ℃, more preferably 40 to 45 ℃; the third mixing means is preferably stirring; the stirring process is not particularly limited in the present invention, and the third mixture may be uniformly dispersed in a manner well known to those skilled in the art.
After the third mixture is obtained, the third mixture, the kuh-seng root extract, the honeysuckle extract, the dandelion extract, the wild chrysanthemum extract and the paeonia root extract are mixed for the fourth time to obtain the anti-inflammation acne-removing mask essence.
In the present invention, the temperature of the fourth mixing is preferably 25 to 40 ℃, more preferably 25 to 30 ℃; the time is preferably 20 to 30 minutes, more preferably 20 to 25 minutes; the fourth mixing mode is preferably stirring; the stirring method of the present invention is not particularly limited, and may be any method known to those skilled in the art.
The invention also provides the anti-inflammatory acne-removing mask essence prepared by the technical scheme or the application of the anti-inflammatory acne-removing mask essence prepared by the preparation method in skin care products.
The application process of the anti-inflammatory acne-removing mask essence in skin care products is not limited in any particular way, and the anti-inflammatory acne-removing mask essence is prepared by a mode well known to those skilled in the art.
The invention also provides an anti-inflammatory acne-removing mask which comprises mask paper and mask essence;
the mask essence is the anti-inflammatory acne-removing mask essence prepared by the technical scheme or the preparation method.
In the invention, the adding amount of the mask essence in the anti-inflammatory acne-removing mask is preferably 25-35 mL/tablet, more preferably 25-30 mL/tablet, and most preferably 25 mL/tablet.
For further explanation of the present invention, the anti-inflammatory and acne-removing mask essence, the preparation method and application thereof, and the anti-inflammatory and acne-removing mask provided by the present invention are described in detail below with reference to the accompanying drawings and examples, but they are not to be construed as limiting the scope of the present invention.
Example 1
The following raw materials are prepared in parts by weight: 0.1 part of hydrolyzed sclerotium rolfsii gum, 0.1 part of hydrolyzed sodium hyaluronate, 0.1 part of disodium ethylenediamine tetraacetate, 0.1 part of allantoin, 0.8 part of betaine, 0.08 part of dipotassium glycyrrhizinate, 2 parts of butanediol, 1.5 parts of glycerol, 0.7 part of beta-glucan, 3 parts of panthenol, 1 part of witch hazel water, 1 part of nicotinamide, 1 part of xanthan gum, 0.5 part of p-hydroxyacetophenone, 0.8 part of 1, 2-hexanediol, 8 parts of kuh-seng root extract, 5 parts of dandelion extract, 5 parts of honeysuckle extract, 3.5 parts of wild chrysanthemum extract, 2 parts of paeonia lactiflora root extract, and adding 63.72 parts of deionized water to complement to 100 parts.
Wherein, the preparation of the kuh-seng root extract: washing radix Sophorae Flavescentis with purified water, soaking in purified water at a ratio of 1:8 for 1 hr, decocting for 2 hr, and sieving the supernatant with 200 mesh sieve; adding purified water into the residue at a feed liquid ratio of 1:5, decocting for 2h, and sieving the supernatant with 200 mesh sieve; mixing the two extractive solutions, centrifuging, filtering, evaporating and concentrating until the solute mass concentration is 1g/mL to obtain crude extract, adding 60% alcohol solution with 2 times of the concentrated solution mass into the concentrated solution by alcohol precipitation, and removing impurities. The total alkali content of the oxymatrine and matrine in the alcohol precipitation product is detected to be 11.7mg/mL by adopting an HPLC method.
Preparing dandelion extract, wild chrysanthemum extract, paeonia extract and honeysuckle extract: cleaning herba Taraxaci, flos Chrysanthemi Indici, radix Paeoniae or flos Lonicerae with purified water respectively, soaking in 10 times of purified water for 1 hr, decocting for 2 hr, filtering the supernatant with 200 mesh sieve, centrifuging, filtering, evaporating and concentrating until the solute mass concentration is 1g/mL to obtain each extractive solution.
Adding the weighed hydrolyzed sclerotium rolfsii, hydrolyzed sodium hyaluronate, disodium ethylenediamine tetraacetate, allantoin, betaine and dipotassium glycyrrhizinate into 57 parts of deionized water, heating to 65 ℃, stirring and melting; after the dissolution is completed, adding the weighed nicotinamide, xanthan gum and p-hydroxyacetophenone at 50 ℃, and stirring until the system is uniform; adding the weighed butanediol, beta-glucan, glycerol, panthenol, hamamelis mollis water, 1, 2-hexanediol and deionized water into the system when the temperature of the system is reduced to 45 ℃, stirring and dissolving; and (3) when the temperature of the system is reduced to 30 ℃, adding the lightyellow sophora root extract, the honeysuckle extract, the dandelion extract, the wild chrysanthemum extract and the paeonia lactiflora root extract into the system, mixing and stirring for 20 minutes, and obtaining the anti-inflammatory acne removing mask essence.
Adding the mask cloth into mask bags, pouring 25mL of the anti-inflammatory acne-removing mask essence containing various natural plant components into each bag, and sealing to obtain the anti-inflammatory acne-removing mask containing various natural plant extracts.
Example 2
The following raw materials are prepared in parts by weight: 0.2 part of hydrolyzed sclerotium rolfsii gum, 0.15 part of hydrolyzed sodium hyaluronate, 0.15 part of disodium ethylenediamine tetraacetate, 0.2 part of allantoin, 1 part of betaine, 0.1 part of dipotassium glycyrrhizinate, 3 parts of butanediol, 3 parts of glycerol, 1 part of beta-glucan, 3 parts of panthenol, 1 part of witch hazel water, 1 part of nicotinamide, 1 part of xanthan gum, 0.5 part of p-hydroxyacetophenone, 0.8 part of 1, 2-hexanediol, 7 parts of radix sophorae flavescentis extract, 4 parts of dandelion extract, 5 parts of honeysuckle extract, 3 parts of wild chrysanthemum extract, 2 parts of paeonia lactiflora extract, and adding 62.9 parts of deionized water to complement to 100 parts. Wherein, the preparation methods of the kuh-seng root extract, the dandelion extract, the honeysuckle extract, the wild chrysanthemum extract and the paeonia lactiflora root extract are the same as in the example 1.
Adding the weighed hydrolyzed sclerotium rolfsii, hydrolyzed sodium hyaluronate, disodium ethylenediamine tetraacetate, allantoin, betaine and dipotassium glycyrrhizinate into 44 parts of deionized water, heating to 65 ℃, stirring and melting; after the dissolution is completed, adding the weighed nicotinamide, xanthan gum and p-hydroxyacetophenone at 50 ℃, and stirring until the system is uniform; adding the weighed butanediol, beta-glucan, glycerol, panthenol, hamamelis mollis water, 1, 2-hexanediol and deionized water into the system when the temperature of the system is reduced to 45 ℃, stirring and dissolving; and (3) when the temperature of the system is reduced to 30 ℃, adding the lightyellow sophora root extract, the honeysuckle extract, the dandelion extract, the wild chrysanthemum extract and the paeonia lactiflora root extract into the system, mixing and stirring for 20 minutes, and obtaining the anti-inflammatory acne removing mask essence.
Adding the mask cloth into mask bags, pouring 25mL of the anti-inflammatory acne-removing mask essence containing various natural plant components into each bag, and sealing to obtain the anti-inflammatory acne-removing mask containing various natural plant extracts.
Example 3
The following raw materials are prepared in parts by weight: 0.3 part of hydrolyzed sclerotium rolfsii gum, 0.2 part of hydrolyzed sodium hyaluronate, 0.1 part of disodium ethylenediamine tetraacetate, 0.3 part of allantoin, 1 part of betaine, 0.1 part of dipotassium glycyrrhizinate, 3 parts of butanediol, 3 parts of glycerol, 1 part of beta-glucan, 3 parts of panthenol, 1 part of witch hazel water, 1 part of nicotinamide, 1 part of xanthan gum, 0.5 part of p-hydroxyacetophenone, 0.8 part of 1, 2-hexanediol, 6 parts of radix sophorae flavescentis extract, 3 parts of dandelion extract, 3 parts of honeysuckle extract, 2 parts of wild chrysanthemum extract, 1 part of paeonia lactiflora extract, and adding 68.7 parts of deionized water to complement to 100 parts. Wherein, the preparation methods of the kuh-seng root extract, the dandelion extract, the honeysuckle extract, the wild chrysanthemum extract and the paeonia lactiflora root extract are the same as in the example 1.
Adding weighed hydrolyzed sclerotium gum, hydrolyzed sodium hyaluronate, disodium ethylenediamine tetraacetate, allantoin, betaine and dipotassium glycyrrhizinate into 35 parts of deionized water, heating to 65 ℃, stirring and melting; after the dissolution is completed, adding the weighed nicotinamide, xanthan gum and p-hydroxyacetophenone at 50 ℃, and stirring until the system is uniform; adding the weighed butanediol, beta-glucan, glycerol, panthenol, hamamelis mollis water, 1, 2-hexanediol and deionized water into the system when the temperature of the system is reduced to 45 ℃, stirring and dissolving; and (3) when the temperature of the system is reduced to 30 ℃, adding the lightyellow sophora root extract, the honeysuckle extract, the dandelion extract, the wild chrysanthemum extract and the paeonia lactiflora root extract into the system, mixing and stirring for 20 minutes, and obtaining the anti-inflammatory acne removing mask essence.
Adding the mask cloth into mask bags, pouring 25mL of the anti-inflammatory acne-removing mask essence containing various natural plant components into each bag, and sealing to obtain the anti-inflammatory acne-removing mask containing various natural plant extracts.
Comparative example
The mask essence and the mask were prepared according to the technical scheme provided in example 3, except that the radix sophorae flavescentis extract, the honeysuckle extract, the dandelion extract, the wild chrysanthemum extract and the paeonia lactiflora extract were not added.
Test example 1
The anti-inflammatory acne-removing mask essence provided by the invention is subjected to sensory evaluation:
10 sensory panelists evaluated the appearance (1.5 points), smell (1.5 points), viscosity (2 points), irritation (2.5 points) and feel of use (2.5 points) of the mask essences of examples 1 to 3, with the evaluation criteria shown in table 1 and the evaluation results shown in table 2.
Table 1 sensory evaluation criteria for mask extracts
Table 2 sensory evaluation results of mask essence
| Sample of | Appearance of | Smell of | Viscosity of the product | Irritation (irritation) | Skin feel for trial | Total score |
| Example 1 | 1.5 | 1.3 | 2.0 | 2.5 | 2.4 | 9.7 |
| Example 2 | 1.5 | 1.5 | 1.9 | 2.5 | 2.4 | 9.8 |
| Example 3 | 1.5 | 1.4 | 1.6 | 2.5 | 2.5 | 9.5 |
| Comparative example | 1.4 | 1.3 | 1.5 | 2.5 | 2.4 | 9.1 |
As can be seen from table 2, the anti-inflammatory acne-removing mask essence provided by the invention has better sensory quality, wherein example 2 is the best.
Test example 2
The anti-inflammatory acne-removing mask essence provided by the invention is subjected to antioxidation efficacy detection:
the DPPH radical scavenging ability test was performed on the samples of the different examples. Positive control Vc formulation: dissolving and diluting with 95% ethanol to obtain the following components: a series of concentration gradients of 0.08g/mL, 0.04g/mL, 0.02g/mL, 0.01g/mL were used to verify the assay system. Preparing 2mmol/L DPPH ethanol solution: 20mg DPPH is weighed, added with absolute ethyl alcohol for dissolution and fixed volume in a 250mL volumetric flask, and stored in a dark place at 4 ℃ (for preparation at present). Sample addition requirements are shown in Table 3, absorbance was measured at 517nm after a reaction time of 30min in the dark, and clearance was calculated according to the following formula.
TABLE 3 sample liquid feeding requirement
Experimental results: positive control IC 50 The experimental system was considered effective in that the absorbance was well-linear with 0.033g/mL, ranging from 0.02 to 0.06 g/mL. The samples were then subjected to antioxidant testing as shown in table 4.
Table 4 the mask essence provided in examples 1 to 3 and comparative example was tested for DPPH radical scavenging ability
| Clearance/% | |
| Example 1 | 26.56±0.01 |
| Example 2 | 43.59±0.03 |
| Example 3 | 36.44±0.25 |
| Comparative example | 5.48±0.75 |
As can be seen from table 4, the anti-inflammatory acne-removing mask essence of the invention has better antioxidant capacity, wherein example 2 is the best, and comparative example is a mask essence test without adding natural plant extract, and the DPPH free radical clearance is extremely low, which indicates that the natural plant extract in the anti-inflammatory acne-removing mask essence provided by the invention is the main active substance.
Test example 3
The anti-inflammatory acne-removing mask essence provided by the invention is tested by the test effect:
(1) Trial selection
Inclusion criteria and exclusion criteria: volunteers entering the study had to meet all of the following criteria: 18-60 years old, unlimited sex, healthy (except pregnant or lactating women or women who are ready to become pregnant in six months); acne volunteers below grade 3 according to acne grade; patients without severe systemic disease, immunodeficiency or autoimmune disease (e.g., heart disease, diabetic); those without highly sensitive constitution; all volunteers had read the informed consent and signed before the study began. None of the objects which do not meet the above requirements are objects to be observed.
(2) Application method
After cleaning the facial skin, the facial mask is applied for 20min, and after finishing, the facial mask is gently massaged to be absorbed, 3 times per week, and the facial mask is continuously used for 14 days.
(3) Effect of use
All volunteers completed trials as prescribed.
Trial 1: men, 26 years old, had a history of 8 years of acne muscles, had no smoking, occasionally had alcohol, and the acne persisted, concentrated around the chin and mouth, occasionally the bridge of the nose, and was not completely eliminated. The anti-inflammatory acne-removing mask is used for two weeks, and the front-back comparison effect is shown in figure 1.
Trial evaluation: the anti-inflammatory and anti-acne effects are good, the acne maturation and crusting time is obviously accelerated, the acne appearance after the use is obviously reduced, the acne marks after the acne elimination are not obvious, the skin feel is mild and not irritative during application, and the face is fresh, water, moist and moisture after application.
The trial 2, female, 26 years old, had a history of 10 years of acne muscles, frequently eaten with a hot snack, the hot pot barbecue appearance was not so much, and the acne occurred. The anti-inflammatory acne-removing mask is used for two weeks, and the front-back comparison effect is shown in figure 2.
Trial evaluation: after the traditional Chinese medicine acne removing mask is used, the skin state is stable, no acne grows, the mask can effectively maintain the skin state stable, the skin is comfortable and moist after the mask is used, and the mask has certain anti-inflammatory and fading effects on new acne.
Trial 3: women, 32 years old, have a history of acne muscles of more than ten years. Acne is occasionally formed on two sides of the chin, other acne removing products are not used, and the anti-inflammation acne removing mask is used for two weeks.
Trial evaluation: when the acne-removing mask is used for half a month, the most edge of the lower lip has obvious red swelling and acnes when the acne-removing mask is used for the first time, and the swelling degree is reduced the next day of the mask application. Within two weeks of continuous application, the chin also had blemishes, which did not swell, with slight acne marks remaining, for various reasons.
Trial 4: women, 33 years old, have a history of acne muscles for many years, and are now first-grade (acne marks are more, and acne is sometimes found on the forehead and both cheeks).
Trial evaluation: the facial mask has good moistening degree, quick absorption, no stickiness and obvious improvement on the acne of the face after two weeks of use.
Trial 5: women, 23 years old, had a history of sensitive muscles and many years old, and were presented as primary/secondary, and the front-to-back comparison effect is shown in figure 3.
Trial evaluation: after the acne removing mask is continuously applied, the effect of eliminating the red swelling of the face is obvious, the swelling degree of the acnes is obviously resolved, but the acnes are not completely resolved. Overall, the observation object has no anaphylactic reaction to the facial mask, and the final acne removing effect is good.
Although the foregoing embodiments have been described in some, but not all embodiments of the invention, other embodiments may be obtained according to the present embodiments without departing from the scope of the invention.
Claims (10)
1. The anti-inflammatory acne-removing mask essence is characterized by comprising the following components in parts by weight: 4 to 10 parts of kuh-seng root extract, 2 to 6 parts of honeysuckle extract, 2 to 6 parts of dandelion extract, 1 to 5 parts of wild chrysanthemum extract, 1 to 3 parts of paeonia root extract, 1 to 3 parts of butanediol, 1 to 3 parts of glycerin, 0.8 to 2 parts of xanthan gum, 0.5 to 1.6 parts of nicotinamide, 0.8 to 1.5 parts of betaine, 0.6 to 1 part of witch hazel water, 0.5 to 3 parts of panthenol, 0.5 to 2 parts of 1, 2-hexanediol, 0.5 to 1.5 parts of beta-glucan, 0.3 to 1.2 parts of p-hydroxyacetophenone, 0.1 to 0.5 part of hydrolyzed sclerotium gum, 0.1 to 0.3 part of sodium hyaluronate, 0.1 to 0.15 part of ethylene diamine tetraacetic acid, 0.08 to 0.15 part of dipotassium glycyrrhizinate and 49 to 84 parts of water.
2. The anti-inflammatory acne-removing mask essence according to claim 1, wherein the preparation method of the kuh-seng root extract, the honeysuckle extract, the dandelion extract, the wild chrysanthemum extract or the paeonia lactiflora root extract independently comprises the following steps:
respectively extracting radix Sophorae Flavescentis, flos Lonicerae, herba Taraxaci, flos Chrysanthemi Indici or radix Paeoniae to obtain radix Sophorae Flavescentis extractive solution, flos Lonicerae extractive solution, herba Taraxaci extractive solution, flos Chrysanthemi Indici extractive solution or radix Paeoniae extractive solution.
3. The anti-inflammatory acne-removing mask essence according to claim 2, wherein the extraction mode is decoction; the decocted solvent is water, the mass ratio of the feed liquid is 1:5-10, and the time is 1.5-2 h.
4. The anti-inflammatory acne-removing mask essence according to claim 2 or 3, wherein when the kuh-seng root extract is prepared, the number of times of extraction is 1 to 3;
when the honeysuckle extract, the dandelion extract, the wild chrysanthemum extract or the paeonia lactiflora extract are prepared, the extraction times are 1-2 times.
5. The anti-inflammatory acne-removing mask essence according to claim 2, wherein the extracted mask essence further comprises sequentially filtering and concentrating;
the filtering comprises centrifugal filtering;
the concentration is evaporation concentration; the solute mass concentration of the extract obtained after concentration is 0.5-2 g/mL.
6. The anti-inflammatory acne-removing mask essence according to claim 2 or 5, wherein when preparing the kuh-seng root extract, further comprising alcohol precipitation to remove impurities;
the alcohol used for removing impurities by alcohol precipitation is ethanol water solution; the volume concentration of the ethanol in the ethanol water solution is 50-60%; the mass ratio of the ethanol aqueous solution to the extracting solution is 1-3:1.
7. The method for preparing the anti-inflammatory acne-removing mask essence according to any one of claims 1 to 6, which is characterized by comprising the following steps:
mixing betaine, hydrolyzed sclerotium rolfsii, allantoin, hydrolyzed sodium hyaluronate, disodium ethylenediamine tetraacetate, dipotassium glycyrrhizinate and part of water for the first time to obtain a first mixture;
second mixing the first mixture, xanthan gum, nicotinamide and p-hydroxyacetophenone to obtain a second mixture;
thirdly mixing the second mixture, butanediol, glycerol, hamamelis virginiana water, panthenol, 1, 2-hexanediol, beta-glucan and the rest water to obtain a third mixture;
and fourthly, mixing the third mixture, the kuh-seng root extract, the honeysuckle extract, the dandelion extract, the wild chrysanthemum extract and the paeonia lactiflora root extract to obtain the anti-inflammation acne-removing mask essence.
8. The method of claim 7, wherein the first mixing temperature is 60-70 ℃;
the temperature of the second mixing is 50-60 ℃;
the temperature of the third mixing is 40-50 ℃;
the fourth mixing temperature is 25-40 ℃.
9. The use of the anti-inflammatory and acne-removing mask essence according to any one of claims 1 to 6 or the anti-inflammatory and acne-removing mask essence prepared by the preparation method according to claim 7 or 8 in skin care products.
10. An anti-inflammatory acne-removing mask is characterized by comprising mask paper and mask essence;
the mask essence is an anti-inflammatory acne-removing mask essence according to any one of claims 1 to 6 or an anti-inflammatory acne-removing mask essence prepared by the preparation method of claim 7 or 8.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117530902A (en) * | 2023-12-08 | 2024-02-09 | 广东丸美生物技术股份有限公司 | Acne-removing and inflammation-diminishing composition containing sulfated schizophyllan and application of composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117530902A (en) * | 2023-12-08 | 2024-02-09 | 广东丸美生物技术股份有限公司 | Acne-removing and inflammation-diminishing composition containing sulfated schizophyllan and application of composition |
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