CN116997263A - 包含赛门苷i的甜味剂组合物及其用途 - Google Patents
包含赛门苷i的甜味剂组合物及其用途 Download PDFInfo
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- CN116997263A CN116997263A CN202280020341.8A CN202280020341A CN116997263A CN 116997263 A CN116997263 A CN 116997263A CN 202280020341 A CN202280020341 A CN 202280020341A CN 116997263 A CN116997263 A CN 116997263A
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- Prior art keywords
- sugar
- syrup
- flavor
- acid
- siamenoside
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Abstract
本文提供了包含赛门苷I的制剂,其中提供该制剂用于可摄取产品,例如食物或饮料产品或药物,或用于非食用产品,例如化妆品或卫生用品。
Description
技术领域
本公开涉及化学和食物、饮料和其他可摄取组合物领域。更具体而言,本公开涉及用于可摄取组合物例如食物和饮料的包含赛门苷I(siamenoside I)的甜味剂组合物,以及其他可摄取或口服施用的医药产品或组合物。
背景技术
味觉系统提供关于外部世界化学组成的感官信息。味觉转导是动物中化学触发的感觉的最复杂形式之一。从简单的后生动物到最复杂的脊椎动物,在整个动物界中都可以找到味觉信号。据信,哺乳动物通过位于味蕾中味觉受体细胞表面的特定化学感应受体和离子通道来识别五种基本的味觉模式:甜味、苦味、酸味、咸味和鲜味(谷氨酸单钠的味道,或美味(savory)味道)。
甜味是在食用含糖量高的食物时最常感受到的味道。哺乳动物通常感受到甜味是一种令人愉悦的感觉,除非过量。有热量甜味剂,例如蔗糖和果糖,是甜味物质的典型例子。尽管存在多种无热量和低热量的替代品,但是这些有热量甜味剂仍然是可食用产品在食用时引起甜味感知的主要手段。
代谢紊乱和相关疾病,例如肥胖、糖尿病和心血管疾病,是全世界主要的公共卫生问题。在几乎每个发达国家,它们的流行率都以惊人的速度增长。有热量甜味剂是导致这一趋势的关键因素,因为它们已包含在各种包装的食物和饮料产品中,使它们对消费者而言更可口。在许多情况下,可以在食物和饮料中使用无热量或低热量的替代品来代替蔗糖或果糖。即便如此,这些化合物赋予的甜味不同于有热量甜味剂,并且许多消费者未能将其视为合适的替代品。而且,此类化合物可能难以掺入到某些产品中。在某些情况下,它们可以用作有热量甜味剂的部分替代品,但是它们的存在会导致许多消费者感觉到不愉快的异味,包括涩味、苦味以及金属味和甘草的味道。因此,低热量甜味剂在其采用方面面临某些挑战。因此,持续需要发现甜味剂和甜味剂组合物,其能赋予食物和饮料甜味,而不会以有损消费者在食用或饮用含有此类甜味剂的产品中体验到的愉悦感的方式改变其所感知的味道。
发明内容
本文提供的一些实施方案涉及一种制剂(formulation),包含赛门苷I;以及如下的至少一种或多种:(i)一种或多种另外的甜味剂;(ii)一种或多种调味修饰(modifying)化合物;或(iii)调味剂。
在一些实施方案中,一种或多种另外的甜味剂可以从由如下构成的群组中选出:龙舌兰菊粉、龙舌兰花蜜、龙舌兰糖浆、日本甘酒(amazake)、布拉齐因(brazzein)、糙米糖浆、椰子晶体、椰子糖、椰子糖浆、枣糖、果聚糖(也称为菊粉纤维、果糖低聚糖或低聚果糖)、绿色甜菊粉、甜叶菊(Stevia rebaudiana)、莱鲍迪苷A、莱鲍迪苷B、莱鲍迪苷C、莱鲍迪苷D、莱鲍迪苷E、莱鲍迪苷F、莱鲍迪苷I、莱鲍迪苷H、莱鲍迪苷L、莱鲍迪苷K、莱鲍迪苷J、莱鲍迪苷N、莱鲍迪苷O、莱鲍迪苷M和其他甜叶菊基糖苷、甜菊苷、甜菊苷提取物、蜂蜜、菊芋(Jerusalem artichoke)糖浆、甘草根、罗汉果(果实、粉末或提取物)、蛋黄果(lucuma)(果实、粉末或提取物)、枫树树液(包括例如从糖枫(Acer saccharum)、黑枫(Acer nigrum)、美国红枫(Acer rubrum)、银枫(Acer saccharinum)、挪威枫(Acer platanoides)、梣叶槭(Acer negundo)、大叶枫(Acer macrophyllum)、粗齿枫(Acer grandidentatum)、落基山枫(Acer glabrum)、色木槭(Acer mono)提取的树液)、枫树糖浆、枫糖、胡桃树液(包括例如从白胡桃(Juglans cinerea)、黑胡桃(Juglans nigra)、鬼胡桃(Juglans ailatifolia)、胡桃(Juglans regia)提取的树液)、桦树树液(包括例如从纸桦(Betula papyrifera)、加拿大黄桦(Betula alleghaniensis)、山桦(Betula lenta)、河桦(Betula nigra)、灰色桦木(Betula populifolia)、垂枝桦(Betula pendula)提取的树液)、美国梧桐(sycamore)树液(例如从一球悬铃木(Platanus occidentalis)提取的树液)、铁木树液(例如从美洲铁木(Ostrya virginiana)提取的树液)、未精制蔗糖(mascobado)、糖蜜(molasses)(举例而言例如黑糖蜜(blackstrap molasses))、糖蜜糖、莫纳甜、莫奈林(monellin)、甘蔗糖(canesugar)(也称为天然糖、未精制苷蔗糖或蔗糖(sucrose))、棕榈糖、墨西哥粗糖(panocha)、墨西哥粗糖条(piloncillo)、红糖砖(rapadura)、原糖、大米糖浆、高粱、高粱糖浆、木薯糖浆(也称为木薯淀粉糖浆)、奇异果甜蛋白(thaumatin)、雪莲果(yacon root)、麦芽糖浆、大麦麦芽糖浆、大麦麦芽粉、甜菜糖、甘蔗糖(cane sugar)、结晶果汁结晶、焦糖、卡必醇、角豆(carob)糖浆、蓖麻糖、氢化淀粉水纯露(hydrolates)、水解的罐装果汁、水解淀粉、转化糖、茴香脑、阿拉伯半乳聚糖、浓缩葡萄汁(arrope)、糖浆、P-4000、乙酰磺胺酸钾(也称为乙酰舒泛钾或ace-K)、阿力甜(也称为阿力糖(aclame))、爱德万甜、阿斯巴甜、白云参苷(baiyunosdie)、纽甜、苯甲酰胺衍生物、bernadame、阿斯巴甜别名(canderel)、胍甜味剂(carrelame)和其他胍基甜味剂、植物纤维、玉米糖、偶联糖、仙茅甜蛋白、环己氨基磺酸盐(cyclamates)、青钱柳苷I(cyclocaryoside I)、德梅拉拉糖(demerara)、葡聚糖、糊精、糖化麦芽(diastatic malt)、甘素(dulcin)、甜精(sucrol)、乙氧基苯脲(valzin)、杜尔可苷A、杜尔可苷B、艾木林(emulin)、甘草次酸(enoxolone)、麦芽糊精、糖精、草蒿脑(estragole)、乙基麦芽酚、羟苯基甘胺酸(glucin)、葡萄糖酸、葡萄糖酸内酯、葡糖胺、葡萄糖醛酸、甘油、甘氨酸、glycyphillin、甘草甜素、甘草次酸单葡糖醛酸化物、金黄糖、黄糖、金黄糖浆、砂糖、绞股蓝、贺兰甜精(hernandulcin)、异构化液体糖、jallab、菊苣根膳食纤维、犬尿氨酸衍生物(包括N'-甲酰基-犬尿氨酸、N'-乙酰基-犬尿氨酸、6-氯-犬尿氨酸)、半乳糖醇、利体素(litesse)、健美原蔗金砂糖(ligicane)、利卡新(lycasin)、N-(4-氰基苯基)-N-(2,3-亚甲二氧苄基)胍乙酸(lugduname)、胍、法勒南糖浆(falernum)、马槟榔甜蛋白I、马槟榔甜蛋白II、麦芽酚、结晶麦芽糖醇(maltisorb)、麦芽糊精、麦芽三糖醇(maltotriol)、甘露糖胺、神秘果蛋白(micraculin)、水饴(mizuame)、其他罗汉果苷(包括例如罗汉果苷IV、罗汉果苷V、新罗汉果苷、西拉糖和异罗汉果苷IVE)、无患子倍半萜苷(mukurozioside)、纳米糖(nano sugar)、柚皮苷二氢查尔酮、新橙皮苷二氢查尔酮、粗糖(nib sugar)、黑寡糖、诺布糖(norbu)、杏仁糖浆、欧亚水龙骨甜素(osladin)、派克梅兹(pekmez)、潘塔亭(pentadin)、巴西甘草甜素I(periandrin I)、紫苏醛、紫苏葶(perillartine)、petphyllum、苯丙氨酸、假秦艽苷I(phloisosideside I)、根皮素、phlorodizin、叶甜素(phyllodulcin)、氢化葡萄糖浆(polyglycitol syrup)、多足蕨苷A(polypodoside A)、蝶卡苷A(pterocaryoside A)、蝶卡苷B、润贝安娜(rebiana)、精制糖浆、摩擦糖浆(rub syrup)、甜叶悬钩子苷(rubusoside)、蓨蕨素A(selligueain A)、舒格糖(shugr)、赛门苷I、罗汉果(siraitia grosvenorii)、大豆低聚糖、善品糖(Splenda)、SRIoxime V、甜菊醇糖苷、甜菊醇双糖苷、甜菊苷、叉柱花素(strogins)1、2和4、蔗糖酸(sucronic acid)、sucrononate、糖、对硝基苯基脲基丙酸钠(suosan)、根皮苷(phloridzin)、超级阿斯巴甜、四糖、苏糖醇、糖蜜(treacle)、三叶苷(trilobtain)、色氨酸及衍生物(6-三氟甲基-色氨酸、6-氯-D-色氨酸)、香草糖、庚七醇、桦树糖浆、阿斯巴甜-乙酰磺胺酸、艾苏格(assugrin)、以及它们任意两种或更多种的组合或共混物。
在一些实施方案中,一种或多种风味修饰化合物是:
或其盐或溶剂化物;或它们的任意组合。在一些实施方案中,前述风味修饰化合物可以可选地与一种或多种另外的风味修饰化合物组合存在。在一些实施方案中,该一种或多种风味修饰化合物是橙皮素二氢查耳酮、橙皮素二氢查耳酮-4'-O'葡糖苷、新橙皮素二氢查耳酮、布拉齐因、橙皮苷、叶甜素、柚皮素、柚皮苷、根皮素、葡糖基化甜菊醇糖苷、(2R,3R)-3-乙酰氧基-5,7,4'-三羟基黄烷酮、(2R,3R)-3-乙酰氧基-5,7,3'-三羟基-4'-甲氧基黄烷酮、甜叶悬钩子苷、奇异果甜蛋白、莫奈林、神秘果蛋白(miraculin)、甘草甜素及其食用上可接受的盐(例如单铵盐)、柚皮苷二氢查尔酮、杨梅素(myricetin)、川陈皮素(nobiletin)、多甲氧基黄酮、混合的甲氧基黄酮和羟基黄酮、槲皮素(quercetin)、氨基酸,或它们的任意组合。
在一些实施方案中,本文描述的制剂可以是可摄取组合物。在一些实施方案中,可摄取组合物可以呈食物或饮料产品、动物饲料产品、药物组合物、营养产品、膳食补充剂或非处方药物的形式。在一些实施方案中,食物或饮料产品供人类或动物食用。
在一些实施方案中,饮料是从由如下构成的群组中选出的:起泡饮料、果汁、水果味果汁、果汁饮料、蜜汁饮料、蔬菜汁、蔬菜味汁、运动饮料、能量饮料、强化水饮料、含维生素强化水、近水饮料、椰子水、茶类饮料、咖啡、可可饮料、含奶成分的饮料、奶替代品饮料、含谷物提取物的饮料和冰沙(smoothie)。
在一些实施方案中,饮料产品可包含:柠檬酸、磷酸、抗坏血酸、硫酸氢钠、乳酸和/或酒石酸;咖啡因、奎宁、绿茶、儿茶素、多酚、罗布斯塔咖啡生豆提取物、咖啡生豆提取物、乳清分离蛋白和/或氯化钾;焦糖色、红色#40、黄色#5、黄色#6、蓝色#1、红色#3、紫色胡萝卜、黑色胡萝卜汁、紫色地瓜、蔬菜汁、果汁、β-胡萝卜素、姜黄姜黄素和/或二氧化钛;苯甲酸钠、苯甲酸钾、山梨酸钾、偏亚硫酸氢钠、山梨酸和/或苯甲酸;抗坏血酸、EDTA钙二钠、α-生育酚、混合生育酚、迷迭香提取物、葡萄籽提取物、白藜芦醇和/或六偏磷酸钠;白藜芦醇、Co-Q10、ω3脂肪酸、茶氨酸、氯化胆碱(胞磷胆碱(Citocoline))、善倍素(fibersol)、菊粉(菊苣根)、牛磺酸、人参提取物、瓜拉那提取物、生姜提取物、L-苯丙氨酸、L-肉碱、L-酒石酸盐、D-葡萄糖醛酸内酯、肌醇、生物类黄酮、紫锥菊、银杏(Ginkgo Biloba)、马黛茶(yerbamate)、亚麻籽油、藤黄果(Garcinia cambogia)皮提取物、白茶提取物、核糖、奶蓟草(milkthistle)提取物、葡萄籽提取物、盐酸吡多醇(维生素B6)、氰钴胺(维生素B12)、烟酰胺(维生素B3)、生物素、乳酸钙、泛酸钙(泛酸)、磷酸钙、碳酸钙、氯化铬、多烟酸铬、硫酸铜、叶酸、焦磷酸铁、铁、乳酸镁、碳酸镁、硫酸镁、磷酸一钾、磷酸一钠、磷、碘化钾、磷酸钾、核黄素、硫酸钠、葡萄糖酸钠、聚磷酸钠、碳酸氢钠、硫胺素单硝酸盐、维生素D3、维生素A棕榈酸酯、葡萄糖酸锌、乳酸锌,和/或硫酸锌;木犀草素、芹菜素、橘皮素(tangeritin)、槲皮素、山柰酚(kaempferol)、杨梅素(myricetin)、漆黄素(fisetin)、高良姜素、异鼠李素、藿香黄酮醇(pachypodol)、鼠李秦素(rhamnazin)、猫尾草异黄酮(alpinumisoflavone)、二-O-甲基猫尾草异黄酮、4'-甲基-猫尾草异黄酮、5,3',4'-三羟基-2",2"-二甲基吡喃并(5",6":7,8)异黄酮、水黄皮色原烯(karanjachromene)、花旗松素(taxifolin)(或二氢槲皮素)、二氢山柰酚、呋喃黄酮醇(furanoflavonols)、橙皮素、柚皮素、圣草酚、高圣草酚、儿茶素、没食子儿茶素(gallocatechin)、儿茶素3-没食子酸酯、没食子儿茶素3-没食子酸酯、表儿茶素、表没食子儿茶素、表儿茶素3-没食子酸酯、表没食子儿茶素3-没食子酸酯、茶黄素、原花青素(proanthocyanidin)、2R,3R-香橙素-3-O-乙酸酯(2R,3R-aromadendrin-3-O-acetate)、4'-甲氧基二氢槲皮素-3-O-乙酸酯、甜橙黄酮(sinensetin)、六甲氧基栎草亭(hexamethoxy quercetogetin)、川陈皮素、5,6,7-三甲氧基-2-(4-甲氧基苯基)-4H-苯并吡喃-4-酮、七甲氧基黄酮和/或桔皮素(tangeretin);酯胶、溴化植物油(BVO)或乙酸异丁酸蔗糖酯(SAIB);柠檬酸钠、柠檬酸钾、和/或盐;丙二醇、乙醇、甘油、阿拉伯胶(金合欢胶)、麦芽糊精、改性玉米淀粉、右旋糖、天然调味料、具有其他天然调味料的天然调味料(天然调味料WONF)、天然和人工调味料、人工调味料、二氧化硅、碳酸镁、或磷酸三钙;或果胶、黄原胶、羧甲基纤维素(CMC)、聚山梨酯60、聚山梨酯80、中链甘油三酸酯、纤维素凝胶、纤维素胶、酪蛋白酸钠、改性食品淀粉、阿拉伯胶(金合欢胶)、和/或角叉菜胶;或它们的任意组合。
在一些实施方案中,制剂增强或补充了另外的甜味剂和/或风味调节剂的甜度。在一些实施方案中,赛门苷I与一种或多种甜菊醇糖苷例如莱鲍迪苷A、莱鲍迪苷M等组合使用。在一些此类实施方案中,赛门苷I与莱鲍迪苷M组合使用。在此类制剂中,赛门苷I和莱鲍迪苷M可以以相对于彼此的任何合适的重量比存在。在一些此类实施方案中,赛门苷I与莱鲍迪苷M的重量比范围为1:100至100:1,或1:50至50:1,或1:20至20:1,或1:10至10:1,或1:5至5:1,或1:3至3:1,或1:2至2:1。在一些其他实施方案中,赛门苷I与罗汉果汁(作为浓缩物或以非浓缩形式)或罗汉果提取物组合使用。一般而言,基于果汁或提取物中固体的总重量,罗汉果汁或提取物含有至少1重量%的罗汉果苷V。在此类制剂中,赛门苷I和罗汉果汁或提取物可以以相对于彼此的任何合适的重量比存在。在一些此类实施方案中,赛门苷I与罗汉果汁或提取物的重量比(基于固体的重量)范围为1:100至100:1,或1:50至50:1,或1:20至20:1,或1:10至10:1,或1:5至5:1,或1:3至3:1,或1:2至2:1。在一些其他实施方案中,赛门苷I与西拉糖组合使用。在此类制剂中,赛门苷I和西拉糖可以以相对于彼此的任何合适的重量比存在。在一些此类实施方案中,赛门苷I与西拉糖的重量比范围为1:100至100:1,或1:50至50:1,或1:20至20:1,或1:10至10:1,或1:5至5:1,或1:3至3:1,或1:2至2:1。在一些其他实施方案中,赛门苷I与赋予或增强鲜味的化合物组合使用,所述化合物例如谷氨酸盐(例如MSG)、精氨酸盐、酵母提取物、嘌呤核糖核苷酸(例如肌苷单磷酸或鸟苷单磷酸)、氨基酸、寡肽等。赛门苷I与此类鲜味赋予成分或鲜味增强成分的此类组合可有助于赋予各种甜味食品例如甜味乳制品或乳制品类似物更圆润的味道。
在一些实施方案中,赛门苷I以1ppm至1000ppm的量存在。在其他实施方案中,赛门苷I以50ppm或更少的量存在。在另外的其他实施方案中,赛门苷I以25ppm或更少的量存在。
在一些实施方案中,风味修饰化合物是减少酸味、减少甘草味道、阻断苦味、增强鲜味、增强咸味、增强清凉效果或前述的任意组合的化合物。在一些实施方案中,风味修饰化合物是增强甜度的化合物。
在某些形态中,赛门苷I用于减少或阻断可食用产品中常见的某些促苦味剂(bitter tastants)的苦味。此类促苦味剂的例子包括但不限于咖啡因、维生素、矿物质、氯化钾、奎宁、营养化合物和药物化合物。当以这样的方式用于食物产品、饮料、营养制品或药物产品时,赛门苷I以范围为1ppm至300ppm,或1ppm至200ppm,或1ppm至100ppm,或1ppm至75ppm,或1ppm至50ppm,或1ppm至40ppm的浓度存在。
在某些形态中,赛门苷I用于减少可食用产品中常见的某些促酸味剂(sourtastants)的酸味。此类促酸味剂的例子包括但不限于有机酸,例如柠檬酸、乙酸、丙二酸、乳酸等。当以这样的方式用于食物产品或饮料中时,赛门苷I以范围为1ppm至300ppm,或1ppm至200ppm,或1ppm至100ppm,或1ppm至75ppm,或1ppm至50ppm,或1ppm至40ppm的浓度存在。
在某些形态中,赛门苷I用于减少或掩盖可食用产品例如肉或乳制品类似物中常见的植物蛋白的异味。赋予这种异味的植物蛋白的非限制性例子包括豌豆蛋白、大豆蛋白、坚果蛋白等。例如,在一些实施方案中,异味是豌豆蛋白的生青(green)味或谷物味。在一些实施方案中,食物或饮料产品是乳制品类似物产品,例如基于植物的奶仿品、含奶饮料、奶酪、酸奶、开菲乳(kefir)等。在一些实施方案中,食物或饮料产品是肉类似物(meatanalogue,人造肉)产品,例如牛肉、猪肉、羔羊肉、鸡肉、火鸡肉、鹅肉、山羊肉、鱼肉、贝类等的植物仿品。当以这样的方式用于食物产品或饮料中时,赛门苷I以范围为1ppm至300ppm,或1ppm至200ppm,或1ppm至100ppm,或1ppm至75ppm,或1ppm至50ppm,或1ppm至40ppm的浓度存在。
在某些形态中,当与清凉化合物例如薄荷醇、荜澄茄醇等组合使用时,赛门苷I用于增强清凉效果或味道。在其一些实施方案中,赛门苷I用于各种口腔护理产品,例如牙膏、漱口水、亮白产品、洁齿剂等。当以这样的方式使用时,赛门苷I以范围为1ppm至300ppm,或1ppm至200ppm,或1ppm至100ppm,或1ppm至75ppm,或1ppm至50ppm,或1ppm至40ppm的浓度存在。
在某些形态中,当与源自藻类或海鲜的材料组合使用时,赛门苷I用于减少或掩盖鱼腥味。在某些情况下,鱼腥味物质是胺或ω3脂肪酸酯及其脂肪酸氧化产物。在其一些实施方案中,赛门苷I用于含有藻类衍生材料(例如藻类衍生蛋白质、纤维等)的各种食物或饮料产品中。当以这样的方式使用时,赛门苷I以范围为1ppm至300ppm,或1ppm至200ppm,或1ppm至100ppm,或1ppm至75ppm,或1ppm至50ppm,或1ppm至40ppm的浓度存在。
在某些形态中,赛门苷I与一种或多种类黄酮组合使用以改善类黄酮的水溶性。可以受益于该组合的合适的类黄酮包括但不限于橙皮素二氢查耳酮、橙皮素二氢查耳酮-4'-O'葡萄糖苷、新橙皮素二氢查耳酮、橙皮苷、柚皮素、柚皮苷、根皮素、(2R,3R)-3-乙酰氧基-5,7,4'-三羟基黄烷酮、(2R,3R)-3-乙酰氧基-5,7,3'-三羟基-4'-甲氧基黄酮、柚皮苷二氢查耳酮、川陈皮素、多甲氧基黄酮、混合的甲氧基黄酮和羟基黄酮、槲皮素、氨基酸、或它们的任意组合。当以这样的方式使用时,赛门苷I以范围为1ppm至300ppm,或1ppm至200ppm,或1ppm至100ppm,或1ppm至75ppm,或1ppm至50ppm,或1ppm至40ppm的浓度存在。在此类制剂中,赛门苷I和黄酮类化合物可以以相对于彼此的任何合适的重量比存在。在一些此类实施方案中,赛门苷I与类黄酮的重量比范围为1:100至100:1,或1:50至50:1,或1:20至20:1,或1:10至10:1,或1:5至5:1,或1:3至3:1,或1:2至2:1。
在某些形态中,(如在本文提出的任何组合或实施方案中使用的)赛门苷I可以被合适的可食用包装剂,例如基于淀粉或改性淀粉的包封剂包封。这种包封可以通过任何合适的方法,例如喷雾干燥、挤出等来进行。
除了上述特征之外,附加的特征和变型将从下面的描述中变得显而易见。应当理解,以下描述描述了典型的替代方案,并且不旨在限制范围。尽管以本文所提供的各种示例性替代方案和实施方式描述了本公开,但是应当理解,在一个或多个单独替代方案中描述的各种特征、形态和功能并不限于它们对其所描述的特定替代方案的适用性。相反,它们可以单独或以各种组合应用于一个或多个其他替代方案,无论该替代方案是否被描述也无论该特征是否被呈现为所描述的替代方案的一部分。因此,本公开的广度和范围不应受到本文描述的任何示例性替代方案的限制。
具体实施方式
本文公开的实施方案概括而言涉及一种制剂,其包含赛门苷I,可选地与一种或多种另外的甜味剂和/或一种或多种风味修饰化合物组合。在一些实施方案中,制剂包含赛门苷I和可选的一种或多种另外的甜味剂和/或可选的一种或多种调味剂和/或可选的一种或多种风味修饰化合物(包括可以在体外激活甜味受体的风味修饰化合物并赋予甜度增强效果)的组合。本文描述的制剂可以用于多种可摄取或不可摄取的组合物中。在一些实施方案中,可摄取组合物包含赛门苷I、一种或多种另外的甜味剂和可选的一种或多种风味修饰化合物。本公开还涉及包含赛门苷I的制剂,其可以通过利用另外的天然和/或合成的甜味剂和/或风味修饰化合物赋予更类似糖的味道或特性来改善无热量或低热量天然和/或合成高效甜味剂的味道。在一些实施方案中,可摄取组合物提供包括甜味开始和甜味持续的更类似糖的时间概貌(profile),和/或更类似糖的风味概貌。
在一些实施方案中,可摄取组合物可以是食物或饮料产品。
在一些实施方案中,饮料可以从由如下构成的群组中选出:增强型起泡饮料、碳酸软饮料、果汁、水果味果汁、果汁饮料、蜜汁饮料、蔬菜汁、蔬菜味汁、运动饮料、能量饮料、强化水饮料、含维生素强化水、近水饮料、椰子水、茶类饮料、咖啡、可可饮料、含奶成分的饮料、奶替代品饮料、含谷物提取物的饮料和冰沙。
在一些实施方案中,组合物可以是动物饲料产品或动物饲料成分。
在一些实施方案中,可摄取组合物可以是药物产品、营养产品、膳食补充剂或非处方药物。在一些实施方案中,不可摄取组合物可以是口腔护理产品、卫生用品或化妆品。
本公开的这些和其他实施方案、优点和特征一部分在下面的描述中提供,一部分将从该描述中变得显而易见,或者可以通过实践本文公开的实施方案了解到。应当理解,前面的概括性描述和下面的详细描述都仅是示例性和解释性的,而不是对所描述的实施方案的限制。
定义
除非另外定义,否则本文中使用的所有技术和科学术语都具有与本公开所属领域的普通技术人员通常理解的相同含义。所有专利、申请、已公开的申请和其他出版物均通过引用整体并入。如果本文中的术语有多种定义,则除非另有说明,否则以本节中的定义为准。
术语“一种”和“一个”并不表示数量限制,而是表示至少一个所提及的项目的存在。术语“或”或者“和/或”用作功能词来指示两个词或表述一起使用或单独使用。术语“包含”、“具有”、“包括”和“含有”应被解释为开放式术语(例如,含义是“包括但不限于”)。涉及相同组分或性质的所有范围的端点均包括在内且可独立地组合。
“盐”是指具有母体化合物所需活性的化合物的盐。此类盐包括:(1)与无机酸例如盐酸、氢溴酸、硫酸、硝酸、磷酸等形成的酸加成盐;或者与有机酸例如乙酸、丙酸、己酸、环戊烷丙酸、乙醇酸、丙酮酸、乳酸、丙二酸、琥珀酸、苹果酸、马来酸、富马酸、酒石酸、柠檬酸、苯甲酸、3-(4-羟基苯甲酰基)苯甲酸、肉桂酸、扁桃酸、甲磺酸、乙磺酸、1,2-乙二磺酸、2-羟基乙磺酸、苯磺酸、4-氯苯磺酸、2-萘磺酸、4-甲苯磺酸、樟脑磺酸、4-甲基双环[2.2.2]辛-2-烯-1-甲酸、葡庚糖酸、3-苯基丙酸、三甲基乙酸、叔丁基乙酸、十二烷基硫酸、葡萄糖酸、谷氨酸、羟基萘酸、水杨酸、硬脂酸、粘康酸等形成的酸加成盐;(2)当母体化合物中存在的酸性质子被金属离子例如碱金属离子、碱土金属离子或铝离子取代时形成的盐;或与乙醇胺、二乙醇胺、三乙醇胺、N-甲基葡糖胺等有机碱的配位物质。
“摄取上可接受的盐”是指通常被认为对于人类或动物食用安全的盐。
“溶剂化物”意指通过溶剂化形成的化合物(溶剂分子与溶质分子或离子的组合),或由溶质离子或分子,例如本文描述的化合物与一种或多种溶剂分子组成的聚集体。当水为溶剂时,相应的溶剂化物为“水合物”。
“媒介物(vehicle)”是指与化合物组合的稀释剂、佐剂、赋形剂或载体。
如本文所用,“可摄取组合物”包括单独或与另一种物质一起可经口摄取的任何物质,无论是否旨在食用(consumption)。可摄取组合物包括“食物或饮料产品”和“非食用产品”这二者。“食物或饮料产品”是指供人类或动物食用的任何可食用产品,包括固体、半固体或液体(例如饮料)。可摄取组合物还可以包括补充剂、营养制品、功能性食物产品(例如,声称具有超出提供营养素的基本营养功能的健康促进和/或疾病预防特性的任何新鲜或经加工食物)、药物和非处方药物。术语“非食用产品”包括可以被人类或动物出于食用以外的目的摄入口中的任何产品或组合物。例如,非食用产品包括口腔护理产品例如洁齿剂和漱口水,化妆品例如加甜润唇膏,以及可能含有或不含有任何甜味剂的其他个人护理产品。
如本文所用,“动物”包括哺乳动物、鸟类、鱼类、爬行动物和两栖动物。动物的例子包括宠物、牲畜、反刍动物和非反刍动物。
“宠物”是出于陪伴或保护目的而饲养的任何动物,并且可以包括狗、猫、兔、爬行动物、热带鱼、蛙、啮齿动物(包括大鼠、小鼠、仓鼠、沙鼠和豚鼠)、大腹便便的猪、和鸟类(包括雀类、金丝雀和鹦鹉)。在某些情况下,宠物也可以充当工作动物或运动动物。
“牲畜”是指家养动物,其被饲养以:生产食物例如肉、禽、蛋或乳制品;生产纤维和耐磨材料例如羊毛、毛皮、毛发或皮革;或执行诸如为人员或货物提供运输等工作。牲畜的例子包括但不限于牛、马、羊、猪和鸡。
“反刍动物”是具有称为“瘤胃”的专门胃的动物,其中植物性食物在进一步消化之前通过细菌作用发酵。已经摄入并发酵的食物可能会在消化完成之前被反流并再次咀嚼。反刍哺乳动物的胃有四个腔。反刍动物包括但不限于牛、山羊和绵羊。与此同时,“非反刍动物”或“单胃动物”的胃只有一个隔室。非反刍动物可以是草食动物、杂食动物或肉食动物。
在一些实施方案中,可摄取组合物被制备用于动物食用,作为动物饲料产品,或作为动物饲料中的成分。如本文所用,“动物饲料”是指可以被动物食用并且为该动物提供营养的主要生物来源的产品或组合物。动物饲料可以是由多种原材料混合而成的“复合饲料”,通常是为了满足目标动物的特定需要而配制的。动物饲料产品可包括团粒、饼、粗粉、碎屑、颗粒、饮料、浆液、流食等。动物饲料中可添加维生素、矿物质、防腐剂、抗生素、氨基酸、色素和其他添加剂;这些补充剂可以作为商业饲料的一部分提供,也可以作为农民、牧场主和牧民在单独购买或种植的谷物上使用的添加剂提供。
“摄取上可接受的载体或赋形剂”是指一种介质和/或组合物,其用于制备本发明化合物的所需分散剂型,以便以分散/稀释形式施用本发明化合物,使得本发明化合物的生物有效性被最大化。介质和/或组合物可以是取决于产品预期用途的任何形式,例如固体、半固体、液体、糊剂、凝胶、乳剂(lotion)、乳霜(cream)、泡沫材料、悬浮液、溶液或它们的任何组合(例如含有固体成分的液体)。摄取上可接受的载体包括许多常见的食物成分,例如中性、酸性或碱性pH的水、水果或蔬菜汁、醋、腌泡汁、啤酒、葡萄酒、天然水/脂肪乳液例如奶或炼乳、食用油和起酥油、脂肪酸及其烷基酯、丙二醇的低分子量低聚物、脂肪酸的甘油酯、以及此类疏水性物质在水性介质中的分散体或乳液、盐例如氯化钠、多糖例如(但不限于)麦芽糊精、糊精、菊粉、右旋糖酐、聚葡萄糖、其他碳水化合物例如(但不限于)淀粉、小麦粉、玉米粉、大米粉、大米淀粉、木薯粉、木薯淀粉、马铃薯粉、马铃薯淀粉、其他面粉和淀粉、大豆粉、豆粕或其他豆制品、溶剂如乙醇、固体食用稀释剂如蔬菜粗粉或细粉、或其他液体媒介物;分散或悬浮助剂;表面活性剂;等渗剂;增稠剂或乳化剂、防腐剂;固体粘合剂;润滑剂等。
根据本公开,化学感应受体可以是与化学感应感觉或化学感应配体触发的信号转导相关的任何受体,所述转导是例如通过在味蕾或身体内脏器官(例如胃肠道等)中表达的味觉受体或味觉相关受体进行的。在一些实施方案中,化学感应受体是属于7次跨膜受体超家族或G蛋白偶联受体(GPCR)的受体。在另一种实施方案中,化学感应受体是通过一种或多种G蛋白进行信号转导的受体。在又一种实施方案中,化学感应受体是属于GPCR的C家族或C类的受体。在又一种实施方案中,化学感应受体是属于T1R家族的受体。在又一种实施方案中,化学感应受体是T1R1、T1R2、T1R3的受体、或它们的等价物或变体或其组合。在另一种实施方案中,化学感应受体是T1R2和T1R3的异二聚体,或它们的等价物或变体。
本文中的“甜味剂”、“甜味调味剂”、“甜风味实体”或“甜味化合物”是指在受试者中引发可检测到的甜味的化合物或其摄取上可接受的盐,例如果糖或体外激活T1R2/T1R3受体的化合物。
本文中的“风味修饰化合物”或“风味修饰物质”或“风味修饰剂”是指调节(包括增强或加强)和/或诱导动物或人类中调味剂的味道的化合物或其摄取上可接受的盐或溶剂化物。风味修饰化合物的一个例子是甜风味增强剂。
本文中的“风味化剂(flavoring)”或“调味剂(flavoring agent)”是指在动物或人中诱导风味或味道的化合物或其摄取上可接受的盐或溶剂化物。调味剂可以是天然的、半合成的或合成的。
本文中的“风味增强剂”是指增强和/或倍增调味剂或包含调味剂的可摄取组合物的味道的化合物或其摄取上可接受的盐。
本文中的“增强剂”是指调节(增加)风味(例如甜味)或特定受体(优选化学感应受体,例如T1R2/T1R3受体)激活的化合物或其摄取上可接受的盐或溶剂化物。
本文中的“风味(flavor)”是指受试者对味道的感知,其包括甜、酸、咸、苦和鲜。受试者可以是人或动物。
本文中的“甜风味修饰物质”或“甜风味修饰剂”是指调节(包括增强或增加)、诱导或阻断动物或人中甜风味剂的甜味的化合物或其摄取上可接受的盐或溶剂化物。甜风味修饰物质包括甜风味增强剂和甜味调味剂。
本文中的“甜风味增强物质”或“甜风味增强剂”是指甜风味的增强剂,其中术语增强剂与上文所定义的相同。
本文中的“甜风味调节量”是指足以改变(无论增加还是减少)可摄取组合物或其前体中的甜味,足以被人类受试者感知的风味修饰化合物的量。在本公开的许多实施方案中,需要存在至少约0.001ppm的本发明化合物,以便大多数人类受试者感知到包含本发明化合物的可摄取组合物的甜味的调节。通常为了经济地提供所需程度的甜风味调节而采用的宽范围的浓度可以为约0.001ppm至10,000ppm,或者窄范围为约0.1ppm至约1,000ppm。甜风味调节量的替代范围可以为约0.01ppm至约3,000ppm,约0.05ppm至约1,500ppm,约0.1ppm至约500ppm,或约0.1ppm至约300ppm。
本文中的“甜风味增强量”是指如动物或人所感知的,足以增强可摄取组合物中调味剂例如果糖的味道的化合物的量。甜风味增强量的宽范围可以为约0.001ppm至100ppm,或者窄范围为约0.1ppm至约10ppm。甜风味增强量的替代范围可以为约0.01ppm至约30ppm,约0.05ppm至约15ppm,约0.1ppm至约5ppm,或约0.1ppm至约3ppm。在一些实施方案中,甜风味增强量是对应于本公开的甜风味增强剂的配体增强浓度的量。
本文中的“甜味受体调节量”是指足以调节(激活、增强或阻断)甜味受体蛋白的化合物的量。在本公开的许多实施方案中,甜味受体调节量为至少约10nM,或至少约100nM(例如约0.1μM),或至少约1μM,或至少约10μM。“T1R2/T1R3受体调节或激活量”是足以调节或激活T1R2/T1R3受体的化合物的量。“甜味受体”是可以通过甜味化合物调节的味觉受体。优选地,甜味受体是G蛋白偶联受体,并且更优选地,甜味受体是T1R2/T1R3受体。
本公开的化合物的“类似糖”特征包括与蔗糖相似的任何特征,并且包括但不限于最大响应、风味概貌、时间概貌、适应行为、口感、浓度/响应函数、促味剂/和风味/甜味相互作用、空间模式选择性以及温度效应。这些特征是蔗糖味道不同于其他化合物味道的维度。其中,风味概貌和时间概貌尤为重要。在单次品尝甜味食物或饮料时,可以注意到对于蔗糖和其他化合物所观察到的(1)构成甜味剂风味概貌的属性之间的差异和(2)构成甜味剂的时间概貌的甜味开始和消散的速率之间的差异。
赛门苷I组合物
本文公开的实施方案涉及包含赛门苷I的组合物。赛门苷I及其分离已经描述于例如Li et al.,Chinese Journal of Natural Medicines 2014,12(2)89-102,其全部内容通过引用并入。赛门苷I具有下面提供的结构(1)。
在一些实施方案中,(根据上文提出的任何实施方案的)赛门苷I以约0.1重量%至约12重量%的量存在。在一些实施方案中,赛门苷I以约0.2重量%至约10重量%的量存在。在一些实施方案中,赛门苷I以约0.3重量%至约8重量%的量存在。在一些实施方案中,赛门苷I以约0.4重量%至约6重量%的量存在。在一些实施方案中,赛门苷I以约0.5重量%至约5重量%的量存在。在一些实施方案中,赛门苷I以约1重量%至约2重量%的量存在。在一些实施方案中,赛门苷I以约0.1重量%至约5重量%的量存在。在一些实施方案中,赛门苷I以约0.1重量%至约4重量%的量存在。在一些实施方案中,赛门苷I以约0.1重量%至约3重量%的量存在。在一些实施方案中,赛门苷I以约0.1重量%至约2重量%的量存在。在一些实施方案中,赛门苷I以约0.1重量%至约1重量%的量存在。在一些实施方案中,赛门苷I以约0.1重量%至约0.5重量%的量存在。在一些实施方案中,赛门苷I以约0.5重量%至约10重量%的量存在。在一些实施方案中,赛门苷I以约2重量%至约8重量%的量存在。
在一些其他实施例中,赛门苷I以10ppm至1000ppm的量存在。在一些实施方案中,赛门苷I以20ppm至800ppm的量存在。在一些实施方案中,赛门苷I以30ppm至600ppm的量存在。在一些实施方案中,赛门苷I以40ppm至500ppm的量存在。在一些实施方案中,赛门苷I以50ppm至400ppm的量存在。在一些实施方案中,赛门苷I以50ppm至300ppm的量存在。在一些实施方案中,赛门苷I以50ppm至200ppm的量存在。在一些实施方案中,赛门苷I以50ppm至150ppm的量存在。
在一些实施方案中,本文提供的组合物还可包含另外的甜味剂,例如下文详细描述的甜味剂。在一些实施方案中,另外的甜味剂以约0.1重量%至约12重量%的量存在。在一些实施方案中,另外的甜味剂以约0.2重量%至约10重量%的量存在。在一些实施方案中,另外的甜味剂以约0.3重量%至约8重量%的量存在。在一些实施方案中,另外的甜味剂以约0.4重量%至约6重量%的量存在。在一些实施方案中,另外的甜味剂以约0.5重量%至约5重量%的量存在。在一些实施方案中,另外的甜味剂以约1%至约2重量%的量存在。在一些实施方案中,另外的甜味剂以约0.1重量%至约5重量%的量存在。在一些实施方案中,附加甜味剂以约0.1重量%至约4重量%的量存在。在一些实施方案中,另外的甜味剂以约0.1重量%至约3重量%的量存在。在一些实施方案中,另外的甜味剂以约0.1重量%至约2重量%的量存在。在一些实施方案中,另外的甜味剂以约0.1重量%至约1重量%的量存在。在一些实施方案中,另外的甜味剂以约0.1重量%至约0.5重量%的量存在。在一些实施方案中,另外的甜味剂以约0.5重量%至约10重量%的量存在。在一些实施方案中,另外的甜味剂以约2重量%至约8重量%的量存在。
在一些实施方案中,本文提供的组合物还可包含一种或多种如下文详细描述的风味修饰化合物。风味修饰化合物可以以任何合适的量存在。在一些实施方案中,风味修饰化合物以足以增强组合物的味道(例如增强甜味、减少酸味或减少苦味)的量存在。因此,在一些实施方案中,本文提供的组合物包含浓度不大于200ppm,或不大于150ppm,或不大于100ppm,或不大于50ppm,或不大于40ppm,或不大于30ppm,或不大于20ppm的风味修饰化合物。在一些实施方案中,风味修饰化合物以最小量存在,例如1ppm或5ppm。
在一些实施方案中,所述组合物包含浓度范围为1ppm至200ppm,或1ppm至150ppm,或1ppm至100ppm,或1ppm至50ppm,或1ppm至40ppm,或1ppm至30ppm,或1ppm至20ppm,或5ppm至200ppm,或5ppm至150ppm,或5ppm至100ppm,或5ppm至50ppm,或5ppm至40ppm,或5ppm至30ppm,或5ppm至20ppm的风味修饰化合物。在一些实施方案中,组合物中一种或多种风味修饰化合物的量可为约0.001ppm至约100ppm,约0.1ppm至约10ppm,约0.01ppm至约30ppm,约0.05ppm至约15ppm,约0.1ppm至约5ppm,或约0.1ppm至约3ppm。
在一些实施方案中,风味修饰化合物和另外的甜味剂两者都存在并且为约1:100,000至100,000:1的比例或其间的任何比例。在一些实施方案中,风味修饰化合物和另外的甜味剂以约1:90,000、约1:80,000、约1:70,000、约1:60,000、约1:50,000、约1:40,000、约1:30,000、约1:20,000、约1:10,000、约1:9,000、约1:8,000、约1:7,000、约1:6,000、约1:5,000、约1:4,000、约1:3,000、约1:2,000、约1:1,000、约1:900、约1:800、约1:700、约1:600、约1:500、约1:450、约1:400、约1:350、约1:300、约1:250、约1:200、约1:150、约1:100、约1:90、约1:85、约1:80、约1:75、约1:70、约1:65、约1:60、约1:55、约1:50、约1:45、约1:40、约1:35、约1:30、约1:25、约1:20、约1:19、约1:18、约1:17、约1:16、约1:15、约1:14、约1:13、约1:12、约1:11、约1:10、约1:9、约1:8、约1:7、约1:6、约1:5、约1:4、约1:3、约1:2、约1:1、约2:1、约3:1、约4:1、约5:1、约6:1、约7:1、约8:1、约9:1、约10:1、约11:1、约12:1、约13:1、约14:1、约15:1、约16:1、约17:1、约18:1、约19:1、约20:1、约25:1、约30:1、约35:1、约40:1、约45:1、约50:1、约55:1、约60:1、约65:1、约70:1、约75:1、约80:1、约85:1、约90:1、约95:1、约100:1、约150:1、约200:1、约250:1、约300:1、约350:1、约400:1、约450:1、约500:1、约600:1、约700:1、约800:1、约900:1、约1,000:1、约2,000:1、约3,000:1、约4,000:1、约5,000:1、约6,000:1、约7,000:1、约8000:1、约9,000:1、约10,000:1、约20,000:1、约30,000:1、约40,000:1、约50,000:1、约60,000:1、约70,000:1、约80,000:1、约90,000:1、约100,000:1的比例,或它们之间的任何比例存在。
在一些实施方案中,赛门苷I和另外的甜味剂以约1:100,000至100,000:1或其间的任何比例的重量比存在。在一些实施方案中,赛门苷I和另外的甜味剂以约1:90,000、约1:80,000、约1:70,000、约1:60,000、约1:50,000、约1:40,000、约1:30,000、约1:20,000、约1:10,000、约1:9,000、约1:8,000、约1:7,000、约1:6,000、约1:5,000、约1:4,000、约1:3,000、约1:2,000、约1:1,000、约1:900、约1:800、约1:700、约1:600、约1:500、约1:450、约1:400、约1:350、约1:300、约1:250、约1:200、约1:150、约1:100、约1:90、约1:85、约1:80、约1:75、约1:70、约1:65、约1:60、约1:55、约1:50、约1:45、约1:40、约1:35、约1:30、约1:25、约1:20、约1:19、约1:18、约1:17、约1:16、约1:15、约1:14、约1:13、约1:12、约1:11、约1:10、约1:9、约1:8、约1:7、约1:6、约1:5、约1:4、约1:3、约1:2、约1:1、约2:1、约3:1、约4:1、约5:1、约6:1、约7:1、约8:1、约9:1、约10:1、约11:1、约12:1、约13:1、约14:1、约15:1、约16:1、约17:1、约18:1、约19:1、约20:1、约25:1、约30:1、约35:1、约40:1、约45:1、约50:1、约55:1、约60:1、约65:1、约70:1、约75:1、约80:1、约85:1、约90:1、约95:1、约100:1、约150:1、约200:1、约250:1、约300:1、约350:1、约400:1、约450:1、约500:1、约600:1、约700:1、约800:1、约900:1、约1,000:1、约2,000:1、约3,000:1、约4,000:1、约5,000:1、约6,000:1、约7,000:1、约8000:1、约9,000:1、约10,000:1、约20,000:1、约30,000:1、约40,000:1、约50,000:1、约60,000:1、约70,000:1、约80,000:1、约90,000:1、约100,000:1的比例,或它们之间的任何比例存在。
在一些实施方案中,赛门苷I和风味修饰化合物以约1:100,000至100,000:1或其间的任何比例的重量比存在。在一些实施方案中,赛门苷I和风味修饰化合物以约1:90,000、约1:80,000、约1:70,000、约1:60,000、约1:50,000、约1:40,000、约1:30,000、约1:20,000、约1:10,000、约1:9,000、约1:8,000、约1:7,000、约1:6,000、约1:5,000、约1:4,000、约1:3,000、约1:2,000、约1:1,000、约1:900、约1:800、约1:700、约1:600、约1:500、约1:450、约1:400、约1:350、约1:300、约1:250、约1:200、约1:150、约1:100、约1:90、约1:85、约1:80、约1:75、约1:70、约1:65、约1:60、约1:55、约1:50、约1:45、约1:40、约1:35、约1:30、约1:25、约1:20、约1:19、约1:18、约1:17、约1:16、约1:15、约1:14、约1:13、约1:12、约1:11、约1:10、约1:9、约1:8、约1:7、约1:6、约1:5、约1:4、约1:3、约1:2、约1:1、约2:1、约3:1、约4:1、约5:1、约6:1、约7:1、约8:1、约9:1、约10:1、约11:1、约12:1、约13:1、约14:1、约15:1、约16:1、约17:1、约18:1、约19:1、约20:1、约25:1、约30:1、约35:1、约40:1、约45:1、约50:1、约55:1、约60:1、约65:1、约70:1、约75:1、约80:1、约85:1、约90:1、约95:1、约100:1、约150:1、约200:1、约250:1、约300:1、约350:1、约400:1、约450:1、约500:1、约600:1、约700:1、约800:1、约900:1、约1,000:1、约2,000:1、约3,000:1、约4,000:1、约5,000:1、约6,000:1、约7,000:1、约8000:1、约9,000:1、约10,000:1、约20,000:1、约30,000:1、约40,000:1、约50,000:1、约60,000:1、约70,000:1、约80,000:1、约90,000:1、约100,000:1的比例,或它们之间的任何比例存在。
另外的甜味剂
甜味剂具有多种不同的化学结构,因此具有不同的性质,例如但不限于气味、风味、口感和余味。在本文公开的一些实施方案中,本文公开的实施方案还可包括合适的另外的甜味剂或多种甜味剂的组合。在一些实施方案中,另外的甜味剂是常见的糖类甜味剂,例如蔗糖、果糖、葡萄糖,以及包含天然糖例如玉米糖浆(包括高果糖玉米糖浆)或衍生自天然水果和蔬菜来源的其他糖浆或甜味剂浓缩物的甜味剂组合物。在一些实施方案中,另外的甜味剂是蔗糖、果糖或它们的组合。在一些实施方案中,另外的甜味剂是蔗糖。在一些其他实施方案中,另外的甜味剂选自稀有天然糖,包括D-阿洛糖、D-阿洛酮糖、L-核糖、D-塔格糖、L-葡萄糖、L-岩藻糖、L L-阿拉伯糖、D-松二糖、和D-白菌二糖。在一些实施方案中,另外的甜味剂选自半合成的“糖醇”甜味剂,如赤藓糖醇、异麦芽酮糖醇(isomalt)、乳糖醇、甘露糖醇、山梨糖醇、木糖醇、麦芽糊精等。在一些实施方案中,另外的甜味剂选自人工甜味剂,例如阿斯巴甜、糖精、乙酰磺胺酸钾、环己氨磺酸盐、三氯蔗糖和阿力甜。在一些实施方案中,另外的甜味剂从由如下构成的群组中选出:环己氨基磺酸(cyclamic acid)、罗汉果苷、塔格糖、麦芽糖、半乳糖、甘露糖、蔗糖、果糖、乳糖、稀少糖(allulose)、纽甜和其他阿斯巴甜衍生物、葡萄糖、D-色氨酸、甘氨酸、麦芽糖醇、乳糖醇、异麦芽酮糖醇、氢化葡萄糖浆(HGS)、氢化淀粉水解产物(HSH)、甜菊苷、莱鲍迪苷A、其他甜味甜菊基糖苷、化学改性的甜菊醇糖苷(如葡糖基化甜菊醇糖苷)、其他罗汉果苷、化学改性的罗汉果苷(如葡糖基化罗汉果苷)、胍甜味剂(carrelame)和其他胍基甜味剂。在一些实施方案中,另外的甜味剂是本段中阐述的两种或更多种甜味剂的组合。在一些实施方案中,另外的甜味剂可以是本文所公开的两种、三种、四种或五种甜味剂的组合。在一些实施方案中,另外的甜味剂可以是糖。在一些实施方案中,另外的甜味剂可以是一种或多种糖与其他天然和人工甜味剂的组合。在一些实施方案中,另外的甜味剂是糖。在一些实施方案中,糖是甘蔗糖(cane sugar)在一些实施方案中,糖是甜菜糖。在一些实施方案中,糖可以是蔗糖、果糖、葡萄糖或它们的组合。在一些实施方案中,糖可以是蔗糖。在一些实施方案中,糖可以是果糖和葡萄糖的组合。
另外的甜味剂还可以包括例如甜味剂组合物,其包含一种或多种天然或合成碳水化合物,例如玉米糖浆、高果糖玉米糖浆、高麦芽糖玉米糖浆、葡萄糖浆、三氯蔗糖糖浆、氢化葡萄糖浆(HGS)、氢化淀粉水解产物(HSH)或来自天然的水果和蔬菜来源的其他糖浆或甜味剂浓缩物,或半合成“糖醇”甜味剂,例如多元醇。在一些实施方案中,多元醇的非限制性例子包括赤藓糖醇、麦芽糖醇、甘露糖醇、山梨糖醇、乳糖醇、木糖醇、异麦芽酮糖醇、丙二醇、甘油(丙三醇)、苏糖醇、半乳糖醇、帕拉金糖、还原的异麦芽低聚糖、还原的木糖低聚糖、还原的龙胆寡糖、还原的麦芽糖浆、还原的葡萄糖浆、异麦芽酮糖(isomaltulose)、麦芽糊精等,以及能够被还原的不会对味道产生不利影响的糖醇或任何其他碳水化合物或它们的组合。
另外的甜味剂可以是天然或合成的甜味剂,其包括但不限于龙舌兰菊粉、龙舌兰花蜜、龙舌兰糖浆、日本甘酒、布拉齐因、糙米糖浆、椰子晶体、椰子糖、椰子糖浆、枣糖、果聚糖(也称为菊粉纤维、果糖低聚糖或低聚果糖)、绿色甜菊粉、甜叶菊、莱鲍迪苷A、莱鲍迪苷B、莱鲍迪苷C、莱鲍迪苷D、莱鲍迪苷E、莱鲍迪苷F、莱鲍迪苷I、莱鲍迪苷H、莱鲍迪苷L、莱鲍迪苷K、莱鲍迪苷J、莱鲍迪苷N、莱鲍迪苷O、莱鲍迪苷M和其他甜叶菊基甜菊糖苷、甜菊苷、甜菊苷提取物、蜂蜜、菊芋糖浆、甘草根、罗汉果(果实、粉末或提取物)、蛋黄果(果实、粉末或提取物)、枫树树液(包括例如从糖枫、黑枫、美国红枫、银枫、挪威枫、梣叶槭、大叶枫、粗齿枫、落基山枫、色木槭提取的树液)、枫树糖浆、枫糖、胡桃树液(包括例如从白胡桃、黑胡桃、鬼胡桃、胡桃提取的树液)、桦树树液(包括例如从纸桦、加拿大黄桦、山桦、河桦、灰色桦木、垂枝桦提取的树液)、美国梧桐树液(例如从一球悬铃木提取的树液)、铁木树液(例如从美洲铁木提取的树液)、未精制蔗糖、糖蜜(举例而言例如黑糖蜜)、糖蜜糖、莫纳甜、莫奈林、甘蔗糖(也称为天然糖、未精制苷蔗糖或蔗糖)、棕榈糖、墨西哥粗糖、墨西哥粗糖条、红糖砖、原糖、大米糖浆、高粱、高粱糖浆、木薯糖浆(也称为木薯淀粉糖浆)、奇异果甜蛋白、雪莲果、麦芽糖浆、大麦麦芽糖浆、大麦麦芽粉、甜菜糖、甘蔗糖、结晶果汁结晶、焦糖、卡必醇、角豆糖浆、蓖麻糖、氢化淀粉水纯露、水解的罐装果汁、水解淀粉、转化糖、茴香脑、阿拉伯半乳聚糖、浓缩葡萄汁、糖浆、P-4000、乙酰磺胺酸钾(也称为乙酰舒泛钾或ace-K)、阿力甜(也称为阿力糖)、爱德万甜、阿斯巴甜、白云参苷、纽甜、苯甲酰胺衍生物、bernadame、canderel、carrelame和其他胍基甜味剂、植物纤维、玉米糖、偶联糖、仙茅甜蛋白、环己氨基磺酸盐、青钱柳苷I、德梅拉拉糖、葡聚糖、糊精、糖化麦芽、甘素、甜精、乙氧基苯脲、杜尔可苷A、杜尔可苷B、艾木林、甘草次酸、麦芽糊精、糖精、草蒿脑、乙基麦芽酚、羟苯基甘胺酸、葡萄糖酸、葡萄糖酸内酯、葡糖胺、葡萄糖醛酸、甘油、甘氨酸、glycyphillin、甘草甜素、甘草次酸单葡糖醛酸化物、金黄糖、黄糖、金黄糖浆、砂糖、绞股蓝、贺兰甜精、异构化液体糖、jallab、菊苣根膳食纤维、犬尿氨酸衍生物(包括N'-甲酰基-犬尿氨酸、N'-乙酰基-犬尿氨酸、6-氯-犬尿氨酸)、半乳糖醇、利体素、健美原蔗金砂糖、利卡新、N-(4-氰基苯基)-N-(2,3-亚甲二氧苄基)胍乙酸、胍、法勒南糖浆、马槟榔甜蛋白I、马槟榔甜蛋白II、麦芽酚、结晶麦芽糖醇、麦芽糊精、麦芽三糖醇、甘露糖胺、神秘果蛋白、水饴、其他罗汉果苷(包括例如罗汉果苷IV、罗汉果苷V、新罗汉果苷、西拉糖和异罗汉果苷IVE)、无患子倍半萜苷、纳米糖、柚皮苷二氢查尔酮、新橙皮苷二氢查尔酮、粗糖、黑寡糖、诺布糖、杏仁糖浆、欧亚水龙骨甜素、派克梅兹、潘塔亭、巴西甘草甜素I、紫苏醛、紫苏葶、petphyllum、苯丙氨酸、假秦艽苷I、根皮素、phlorodizin、叶甜素、氢化葡萄糖浆、多足蕨苷A、蝶卡苷A、蝶卡苷B、润贝安娜、精制糖浆、摩擦糖浆、甜叶悬钩子苷、蓨蕨素A、舒格糖、赛门苷I、罗汉果、大豆低聚糖、善品糖、SRIoxime V、甜菊醇糖苷、甜菊醇双糖苷、甜菊苷、叉柱花素1、2和4、蔗糖酸、sucrononate、糖、对硝基苯基脲基丙酸钠、根皮苷、超级阿斯巴甜、四糖、苏糖醇、糖蜜、三叶苷、色氨酸及衍生物(6-三氟甲基-色氨酸、6-氯-D-色氨酸)、香草糖、庚七醇、桦树糖浆、阿斯巴甜-乙酰磺胺酸、艾苏格、以及它们任意两种或更多种的组合或共混物。
在又一些实施方案中,另外的甜味剂可以是化学或酶改性的天然高效甜味剂。改性的天然高效甜味剂包括糖基化的天然高效甜味剂,例如含有1~50个糖苷残基的葡糖基、半乳糖基或果糖基衍生物。糖基化的天然高效甜味剂可以通过由具有转糖基化活性的各种酶催化的酶促转糖基化反应来制备。在一些实施方案中,改性甜味剂可以是取代的或未取代的。
另外的甜味剂还包括任何前述甜味剂中的任何两种或更多种的组合。在一些实施方案中,甜味剂可以包含本文所公开的两种、三种、四种或五种甜味剂的组合。在一些实施方案中,甜味剂可以是糖。在一些实施方案中,甜味剂可以是一种或多种糖与其他天然和人工甜味剂的组合。
本领域技术人员将认识到,任何一种或多种前述甜味剂可以以各种比例、量或浓度组合以产生单独的甜味剂或两种或更多种甜味剂的组合,然后将其与一种或多种风味修饰化合物组合。
本领域技术人员将认识到,用于包含赛门苷I和一种或多种另外的甜味剂和/或一种或多种风味修饰化合物的制剂中的前述甜味剂是以举例的方式提供的并且不旨在限制。
风味修饰化合物
在一些实施方案中,一种或多种风味修饰化合物是于2004年8月6日提交的题为“Novel Flavors,Flavor Modifiers,Tastants,Taste Improvers,Umami or SweetTastants,and/or Enhancers and Use Thereof”的美国申请公开号2005/0084506中公开的一种或多种风味修饰化合物,其全部内容通过引用并入本文。在一些实施方案中,一种或多种风味修饰化合物是于2006年6月15日提交的题为“Bis-Aromatic Amides and TheirUses as Sweet Flavor Modifiers,Tastants,and Taste Enhancers”的美国申请公开号2007/0003680中公开的一种或多种风味修饰化合物,其全部内容通过引用并入本文。在一些实施方案中,一种或多种风味修饰化合物是于2007年6月8日提交的题为“Modulation ofChemosensory Receptors and Ligands Associated Therewith”的美国申请公开号2008/0306093中公开的一种或多种风味修饰化合物,其全部内容通过引用并入本文。在一些实施方案中,一种或多种风味修饰化合物是于2011年4月14日提交的题为“Modulation ofChemosensory Receptors and Ligands Associated Therewith”的美国申请公开号2011/0224155中公开的一种或多种风味修饰化合物,其全部内容通过引用并入本文。在一些实施方案中,一种或多种风味修饰化合物是于2011年3月31日提交的题为“Sweet FlavorModifier”的美国申请公开号2011/0245353中公开的一种或多种风味修饰化合物,其全部内容通过引用并入本文。在一些实施方案中,一种或多种风味修饰化合物是于2012年8月10日提交的题为“Sweet Flavor Modifier”的美国申请公开号2013/0041046中公开的一种或多种风味修饰化合物,其全部内容通过引用并入本文。在一些实施方案中,一种或多种风味修饰化合物是于2014年12月4日提交的题为“Sweet Flavor Modifier”的美国申请公开号2014/0094453中公开的一种或多种风味修饰化合物,其全部内容通过引用并入本文。在一些实施方案中,一种或多种风味修饰化合物是于2014年2月19日提交的题为“Sweet FlavorModifier”的美国申请公开号2014/0235624中公开的一种或多种风味修饰化合物,其全部内容通过引用并入本文。在一些实施方案中,一种或多种风味修饰化合物是于2015年8月14日提交的题为“Sweet Flavor Modifier”的美国申请公开号2015/0376176中公开的一种或多种风味修饰化合物,其全部内容通过引用并入本文。在一些实施方案中,一种或多种风味修饰化合物是于2015年10月28日提交的题为“Substituted 4-amino-5-(cyclohexyloxy)quinolone-3-carboxylic acids as Sweet Flavor Modifiers”的美国申请公开号2016/0185727中公开的一种或多种风味修饰化合物,其全部内容通过引用并入本文。
在一些实施方案中,风味修饰化合物是具有环状噻二嗪核的化合物。
在一些实施方案中,一种或多种风味修饰化合物是从由如下构成的群组中选出的一种或多种化合物:
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/>或其盐或溶剂化物,或其任意两种或更多种化合物的任意组合。
一些实施方案包括与本文描述或引用的任何一种或多种风味修饰化合物的组合。
一些实施方案包括与本文描述或引用的任何一种或多种风味修饰化合物的组合。
一些实施方案包括与本文描述或引用的任何一种或多种风味修饰化合物的组合。
一些实施方案包括以下的组合
可选地与本文描述或引用的任何一种或多种另外的风味修饰化合物一起。
一些实施方案包括以下的组合
可选地与本文描述或引用的任何一种或多种另外的风味修饰化合物一起。
一些实施方案包括以下的组合
可选地与本文描述或引用的任何一种或多种另外的风味修饰化合物一起。
在一些实施方案中,风味修饰化合物可以是国际专利公开号WO 2005/041684、WO2012/061698、WO 2014/130582、WO 2017/058594中公开的化合物,或多种化合物的组合,这些专利公开的全部内容通过引用并入本文。
在一些实施方案中,本文所述的制剂包含赛门苷I和一种或多种蛋白质,例如马槟榔甜蛋白-1(Mabinlin-1)、马槟榔甜蛋白-2、马槟榔甜蛋白-3和马槟榔甜蛋白-4;和/或一种或多种茋,包括白皮杉醇(Piceatannol)4'-O-β-D-吡喃葡糖苷和买麻藤素E(GnetifolinE)。
一些实施方案包括本文所述的风味修饰化合物与赛门苷I和本文所述的任何一种或多种另外的甜味剂的任何组合。
在一些实施方案中,风味修饰化合物以约0.00pm至500ppm的量存在。因此,在一些替代方案中,风味修饰化合物的量为0.001、0.01、0.1、1、10、50、100、200、300、400或500ppm或在由任意两项以上值限定的范围内的值。
根据任何前述实施方案提出的可摄取组合物在某些实施方案中还可包含一种或多种另外的风味修饰化合物,例如增强甜味的化合物(例如橙皮素、柚皮素、葡糖基化甜菊醇糖苷等)、阻断苦味的化合物、增强鲜味的化合物、减少酸味或甘草味的化合物、增强咸味的化合物、增强清凉效果的化合物或前述的任何组合。
组合物和用途
本文的一些组合物涉及一种包含赛门苷I的制剂,该赛门苷I可选地与一种或多种本文公开的另外的甜味剂组合,和/或可选地与一种或多种本文所述的风味修饰化合物组合,和/或可选地与一种或多种调味剂组合。因此,应认识到,赛门苷I与一种或多种甜味剂的组合和/或一种或多种风味修饰化合物的组合和/或可选地与本文公开的一种或多种调味剂的组合是非限制性的。在一些实施方案中,包含赛门苷I并可选地与一种或多种甜味剂组合和/或可选地与一种或多种风味修饰化合物组合和/或可选地与一种或多种调味剂组合的所述制剂用作可摄取或不可摄取产品的组合物。
如本文公开的包含赛门苷I的制剂可用于调节化学感应受体和/或其配体,包括调节化学感应受体的活性、结构、功能、表达,和/或化学感应受体的修饰,以及对与化学感应受体相关的病症例如生理或病理病症调节、治疗、或采取预防性措施。一般而言,与化学感应受体相关的生理或病理病症包括与化学感应受体和/或其配体相关的病症、疾病或失调(disorders),例如胃肠失调、代谢失调、功能性胃肠失调等。在一些实施方案中,制剂增加或增强甜风味。在另一种实施方案中,制剂调节在味蕾以外的身体部位(例如内脏器官)表达的甜味受体和/或其配体。一般而言,本公开的制剂可以以组合物,例如可摄取组合物的形式提供。在一些实施方案中,本发明的制剂可通过将一种或多种风味修饰化合物与一种或多种甜味剂在组合制剂中组合而赋予甜味剂组合物更类似糖的时间概貌和/或风味概貌。在另一种实施方案中,本发明的制剂可以通过将其组合物与一种或多种本发明的制剂接触以形成经修饰的组合物来增加或增强组合物的甜味。在另一种实施方案中,本发明的制剂可以是调节在体内而不是在味蕾中表达的甜味受体和/或其配体的组合物。
在本文提供的一些实施方案中,赛门苷I可用作风味修饰化合物。在某些实施方案中,赛门苷I可以对本文所述的甜味剂具有风味修饰作用(例如,甜味修饰作用)。例如,在一些实施方案中,赛门苷I可用作风味修饰化合物与乙酰磺胺酸钾、阿斯巴甜、甜叶菊、甜菊基糖苷和/或罗汉果(果实、粉末或提取物)组合。在本文所述的一些制剂中,赛门苷I可以作为风味修饰化合物以1ppm、2ppm、3ppm、4ppm、5ppm、6ppm、7ppm、8ppm、9ppm、10ppm、15ppm、20ppm、25ppm、30ppm、35ppm、40ppm、45ppm、50ppm、60ppm、70ppm、80ppm、90ppm、100ppm的浓度、或由任何上述浓度限定的范围内存在。
在一些实施方案中,本发明的制剂在体外和/或体内具有蔗糖修饰行为和/或甜味激动剂行为(例如,如感官研究中所示)。在一些实施方案中,本发明的制剂表现出有利的体内副味概貌(side-taste profile)。
制剂是否表现出甜味修饰/激动剂效果可以通过任何合适的测试方法来确定。例如,包含一种或多种甜味剂与风味修饰化合物组合的制剂可以使用人类味觉小组在感官测试中进行评估。
在一些实施方案中,可以在测试之前稀释制剂。在一些实施方案中,在测试之前将制剂稀释约2倍、约5倍、约10倍、约50倍、约100倍、约200倍、约300倍、约400倍、约500倍、约1000倍或更多倍。
可以在有和/或没有添加剂的情况下进行测试。在一些实施方案中,测试该制剂以评估对一种或多种添加剂的甜味增强作用。在测试中,参与者可以提供他们对含和/或不含添加剂的甜味剂组合物与包含糖的甜味剂组合物的特征的相似性的印象。确定组合物是否具有更类似糖的味道的合适程序是通过使用测量制剂甜度的评估员小组进行的。
在一些实施方案中,赛门苷I单独或与本文描述的另一种甜味剂组合用作主要甜味剂。在此类实施方案中,赛门苷I可以以20ppm至800ppm,30ppm至600ppm,40ppm至500ppm,50ppm至400ppm,50ppm至300ppm,50ppm至200ppm,或50ppm至150ppm的浓度存在于食物或饮料中。
一种实施方案提供了一种用于制备即用型组合物(例如最终食物或饮料产品、或动物饲料产品)的方法中的制剂。该方法包括使第一组合物例如含有赛门苷I的第一食物或饮料产品与包含风味修饰化合物的调味浓缩物组合物或制剂(例如固体或液体)接触以形成即用型组合物。
在一些实施方案中,可摄取组合物可以是饮料。在一些实施方案中,饮料可选自增强型起泡饮料、可乐、柠檬-酸橙味起泡饮料、橙味起泡饮料、葡萄味起泡饮料、草莓味起泡饮料、菠萝味起泡饮料、姜汁汽水、根汁啤酒、果汁、水果味果汁、果汁饮料、蜜汁饮料、蔬菜汁、蔬菜味汁、运动饮料、能量饮料、强化水饮料、含维生素强化水、近水饮料、椰子水、茶类饮料、咖啡、可可饮料、含奶成分的饮料、巧克力奶、纯乳制品风味乳饮料、果汁风味乳饮料,牛奶替代饮料,包括米浆、杏仁奶、腰果奶、椰奶、榛子奶、火麻奶、开心果奶、燕麦奶、小麦奶、大麦奶、小米奶、斯佩尔特奶、黑小麦奶和豆奶,酸乳饮料、发酵乳饮料、开菲乳、含有谷物提取物的饮料和冰沙。在一些实施方案中,饮料可以是软饮料。
在一些实施方案中,本文描述的制剂和组合物可以包含在食物或饮料产品中,其中食物或饮料产品可以另外包含:
酸,包括例如柠檬酸、磷酸、抗坏血酸、硫酸氢钠、乳酸、或酒石酸;
苦味成分,包括例如咖啡因、奎宁、绿茶、儿茶素、多酚、罗布斯塔咖啡生豆提取物、咖啡生豆提取物、乳清分离蛋白、或氯化钾;
着色剂,包括例如焦糖色、红色#40、黄色#5、黄色#6、蓝色#1、红色#3、紫色胡萝卜、黑色胡萝卜汁、紫色地瓜、蔬菜汁、果汁、β-胡萝卜素、姜黄姜黄素、或二氧化钛;
防腐剂,包括例如苯甲酸钠、苯甲酸钾、山梨酸钾、偏亚硫酸氢钠、山梨酸、或苯甲酸;
抗氧化剂,包括例如抗坏血酸、EDTA钙二钠、α-生育酚、混合生育酚、迷迭香提取物、葡萄籽提取物、白藜芦醇、或六偏磷酸钠;
维生素或功能性成分,包括例如白藜芦醇、Co-Q10、ω3脂肪酸、茶氨酸、氯化胆碱(胞磷胆碱)、善倍素、菊粉(菊苣根)、牛磺酸、人参提取物、瓜拉那提取物、生姜提取物、L-苯丙氨酸、L-肉碱、L-酒石酸盐、D-葡萄糖醛酸内酯、肌醇、生物类黄酮、紫锥菊、银杏、马黛茶、亚麻籽油、藤黄果皮提取物、白茶提取物、核糖、奶蓟草提取物、葡萄籽提取物、盐酸吡多醇(维生素B6)、氰钴胺(维生素B12)、烟酰胺(维生素B3)、生物素、乳酸钙、泛酸钙(泛酸)、磷酸钙、碳酸钙、氯化铬、多烟酸铬、硫酸铜、叶酸、焦磷酸铁、铁、乳酸镁、碳酸镁、硫酸镁、磷酸一钾、磷酸一钠、磷、碘化钾、磷酸钾、核黄素、硫酸钠、葡萄糖酸钠、聚磷酸钠、碳酸氢钠、硫胺素单硝酸盐、维生素D3、维生素A棕榈酸酯、葡萄糖酸锌、乳酸锌、或硫酸锌;
类黄酮,包括木犀草素、芹菜素、橘皮素、槲皮素、山柰酚、杨梅素、漆黄素、高良姜素、异鼠李素、藿香黄酮醇、鼠李秦素、猫尾草异黄酮、二-O-甲基猫尾草异黄酮、4'-甲基-猫尾草异黄酮、5,3',4'-三羟基-2",2"-二甲基吡喃并(5",6":7,8)异黄酮、水黄皮色原烯、花旗松素(或二氢槲皮素)、二氢山柰酚、呋喃黄酮醇、橙皮素、柚皮素、圣草酚、高圣草酚、儿茶素、没食子儿茶素(GC)、儿茶素3-没食子酸酯(Cg)、没食子儿茶素3-没食子酸酯、表儿茶素、表没食子儿茶素(EGC)、表儿茶素3-没食子酸酯、表没食子儿茶素3-没食子酸酯、茶黄素、原花青素、2R,3R-香橙素-3-O-乙酸酯、4'-甲氧基二氢槲皮素-3-O-乙酸酯、甜橙黄酮、六甲氧基栎草亭、川陈皮素、5,6,7-三甲氧基-2-(4-甲氧基苯基)-4H-苯并吡喃-4-酮、七甲氧基黄酮和桔皮素;
起云剂,包括例如酯胶、溴化植物油(BVO)、或乙酸异丁酸蔗糖酯(SAIB);
缓冲剂,包括例如柠檬酸钠、柠檬酸钾、或盐;
风味剂(flavors,食用香精),包括例如丙二醇、乙醇、甘油、阿拉伯胶(金合欢胶)、麦芽糊精、改性玉米淀粉、右旋糖、天然调味料、具有其他天然调味料的天然调味料(天然调味料WONF)、天然和人工调味料、人工调味料、二氧化硅、碳酸镁、或磷酸三钙;和
稳定剂,包括例如果胶、黄原胶、羧甲基纤维素(CMC)、聚山梨酯60、聚山梨酯80、中链甘油三酸酯、纤维素凝胶、纤维素胶、酪蛋白酸钠、改性食品淀粉、阿拉伯胶(金合欢胶)、或角叉菜胶。
一些实施方案提供补充剂、营养制品、功能性食物产品(例如,声称具有超出提供营养素的基本营养功能的健康促进和/或疾病预防特性的任何新鲜或经加工食物)、动物饲料产品、药物制品、非处方(OTC)产品、口腔护理产品、化妆品例如加甜润唇膏、以及包含本文所述的风味修饰化合物和本文所述的甜味剂的其他个人护理产品。
一般而言,非处方(OTC)产品和口腔护理产品一般是指无需处方和/或无需拜访医疗专业人员即可售的家庭和/或个人使用的产品。OTC产品的例子包括但不限于维生素和膳食补充剂;局部镇痛药和/或麻醉剂;咳嗽、感冒和过敏的治疗药;抗组胺药和/或过敏治疗药;以及它们的组合。维生素和膳食补充剂包括但不限于维生素、膳食补充剂、补品/瓶装营养饮料、儿童专用维生素、膳食补充剂、任何其他有关营养或提供营养的产品以及它们的组合。局部镇痛药和/或麻醉剂包括用于减轻浅表或深层疼痛例如肌肉疼痛的任何局部霜剂/软膏/凝胶;出牙凝胶;含有镇痛成分的贴剂;以及它们的组合。咳嗽、感冒和过敏的治疗药包括但不限于减充血剂、咳嗽治疗药、咽部制剂、药用糖果、抗组胺药和儿童专用的咳嗽、感冒和过敏治疗药;和组合产品。抗组胺药和/或过敏治疗药包括但不限于用于花粉热、鼻部过敏、昆虫叮咬和蜇伤的任何全身治疗。口腔护理产品的例子包括但不限于口腔清洁条、牙膏、牙刷、漱口水/牙齿清洁水、义齿护理剂、口腔清新剂、家用牙齿亮白剂、洁齿剂和牙线。
在一些实施方案中,本文所述的风味修饰化合物和本文所述的甜味剂可包含在食物或饮料产品或制剂中。食物和饮料产品或制剂的例子包括但不限于可摄取产品的甜味包衣、糖霜或糖衣,或包括于以下的任何实体:汤类,干加工食品类,饮料类,即食食品类,罐装或腌制食品类,冷冻加工食品类,冷藏加工食品类,零食食品类,烘焙食品类,糖果类,乳制品类,冰淇淋类,代餐类,意大利面(pasta)和面条类,以及酱料、调味料、调味品类,婴儿食品类和/或涂抹酱类。
一般而言,汤类是指罐装/腌制、脱水、速溶、冷藏、UHT和冷冻汤。为了该定义的目的,汤是指由肉、禽、鱼、蔬菜、谷物、水果和其他成分制成的食品,在液体中煮熟,其中可能包含一些或全部这些成分的可见碎片。它可能是清澈的(作为高汤(broth))或浓稠的(作为杂烩浓汤(chowder)),光滑的,泥状的或大块的,即食的,半浓缩的或浓缩的,并且可冷可热,作为第一道菜或主菜或作为进餐之间的点心(啜饮饮料)。汤可用作制备其他膳食成分的原料,范围从高汤(broth)(清炖肉汤(consommé))到酱汁(基于奶油或起司的汤)。
脱水和烹饪食品类通常是指:(i)烹饪辅助产品,例如:粉状、颗粒状、糊状、浓缩的液体产品,包括浓缩肉汤(bouillon)、肉汤,以及压制块体、片剂或粉状或颗粒状的类似肉汤的产品,其作为成品或作为产品、调味料和配方混合物中的成分单独出售(与技术无关);(ii)膳食溶液产品,例如:脱水汤和冻干汤,包括脱水汤混合物,脱水速溶汤,脱水即食汤,现成菜肴、膳食和单份主菜的脱水或自热制剂,包括意大利面、土豆和米饭;(iii)膳食点缀产品,例如:调味品,腌料,沙拉酱,沙拉浇头,蘸料,拌粉,面糊混合物,储藏稳定的酱料,烧烤酱,液体配方混合物,浓缩物,酱料或酱汁混合物,包括沙拉配方混合物,其作为成品或作为产品中的成分出售,无论是脱水、液态还是冷冻的。
饮料类通常是指饮料、饮料混合物和浓缩物,包括但不限于碳酸饮料和非碳酸饮料,酒精和非酒精饮料,即饮饮料,用于制备饮料(例如苏打水)的液体浓缩制剂,以及干粉饮料前体混合物。饮料类还包括酒精饮料、软饮料、运动饮料、等渗饮料和热饮料。酒精饮料包括但不限于啤酒、苹果酒/梨酒、调味酒精饮料、葡萄酒和烈性酒。软饮料包括但不限于碳酸饮料,例如可乐和非可乐碳酸饮料;水果汁,例如果汁、蜜饮、果汁饮料和水果味饮料;瓶装水,包括苏打水、泉水和纯净/餐用水;功能性饮料,可以是碳酸饮料或无气饮料,包括运动饮料、能量饮料或特效药(elixir)饮料;浓缩液,例如可即饮用的液体和粉末浓缩液。所述饮品,无论是热饮还是冷饮,都包括但不限于咖啡或冰咖啡,例如现磨咖啡、速溶咖啡和混合咖啡;茶或冰茶,例如红茶、绿茶、白茶、乌龙茶和调味茶;以及其他饮料,包括与牛奶或水混合的调味的、基于麦芽或基于植物的粉末、颗粒、块或片剂。
零食(小吃)类通常是指简易、非正式膳食的任何食物,包括但不限于甜味和美味(savory,咸味、辣味等非甜味)零食以及零食棒。零食的例子包括但不限于水果点心、薯片/脆片、挤出零食、玉米饼/玉米片、爆米花、椒盐脆饼、坚果和其他甜味和美味零食。零食棒的例子包括但不限于格兰诺拉麦片/麦片棒、早餐棒、能量棒、水果棒和其他零食棒。
烘焙食品类通常是指任何制备过程中涉及暴露于热或过多阳光下的可食用产品。烘焙食品的例子包括但不限于面包、小圆面包(buns)、饼干、松饼、谷类食品(麦片)、烤面包机糕点、糕点、华夫饼、玉米饼、软饼干、派、百吉饼、蛋挞、乳蛋饼、蛋糕、任何烘焙食品及它们的任何组合。
冰淇淋类通常是指包含奶油、糖和调味品的冷冻甜品。冰淇淋的例子包括但不限于:即食(impulse)冰淇淋;家庭装冰淇淋;冷冻酸奶和手工冰淇淋;意式冰淇淋(gelato);雪酪(sorbet);果子露(sherbet);基于大豆、燕麦、豆类(例如红豆和绿豆)、椰子、坚果和大米的冰淇淋。
糖果类通常是指味道甜的可食用产品。糖果的例子包括但不限于硬糖、明胶、巧克力糖、砂糖食、口香糖等以及任何组合产品。
代餐食品类通常是指旨在替代普通膳食的任何食品,特别是对于那些关注健康或健身的人。代餐的例子包括但不限于减肥产品和康复产品。
即食食品类通常是指无需大量准备或加工即可作为膳食食用的任何食品。即食食品包括制造商为其添加了食谱“技能”的产品,因此具有高度的即食性、完备性和便利性。即食食品的例子包括但不限于罐装/腌制、冷冻、干燥、冷藏的即食食品;晚餐混合品;冷冻比萨;冷藏比萨;和预制沙拉。
意大利面(Pasta)和面条(Noodle)类包括任何意大利面和/或面条,包括但不限于罐装、干燥和冷藏/新鲜的意大利面;以及原味、速食、冷藏、冷冻和零食类面条。
罐装/腌制食品类包括但不限于罐装/腌制的肉和肉制品、鱼/海鲜、蔬菜、西红柿、豆类、水果、即食食品、汤、意大利面和其他罐装/腌制食品。
冷冻加工食品类包括但不限于冷冻加工的红肉、加工的禽肉、加工的鱼/海鲜、加工的蔬菜、肉替代品、加工的马铃薯、烘焙产品、甜点、即食食品、比萨、汤、面条和其他冷冻食品。
干加工食品类包括但不限于大米、甜点混合物、干即食食品、脱水汤、速食汤、干意大利面、原味面条和速食面。冷藏加工食品类包括但不限于冷藏加工的肉类、加工的鱼/海鲜产品、午餐盒、鲜切水果、即食食品、比萨、预制沙拉、汤、新鲜意大利面和面条。
酱料、调味料和调味品类包括但不限于番茄酱和泥、肉汤/汤块、药草和香料、谷氨酸单钠(MSG)、佐餐酱、大豆类酱、意大利面酱、湿/烹饪酱、干酱/粉末混合物、番茄酱、蛋黄酱、芥末、沙拉酱、香醋沙司、蘸料、腌制品以及其他酱料、调味料和调味品。
婴儿食品类包括但不限于基于牛奶或大豆的配方食品;以及准备好的、干燥的和其他婴儿食品。
涂抹酱类包括但不限于果酱和蜜饯、蜂蜜、巧克力酱、坚果类涂抹酱、焦糖饼干(speculoos)涂抹酱、黄油、调味黄油、人造黄油、食用油涂抹酱、液态牛油类(oleos)、奶酪或奶油干酪涂抹酱、美味涂抹酱和酵母类涂抹酱。
乳制品类通常是指从哺乳动物的奶中产生的可食用产品。乳制品的例子包括但不限于饮用奶制品、奶酪、酸奶和酸乳饮料以及其他乳制品。
如下提供可摄取组合物、特别是食物和饮料产品或制剂的另外的例子。示例性的可摄取组合物包括一种或多种糖果、巧克力糖、巧克力片、巧克力板(countlines)、袋装巧克力棒(selflines)/软棒(softlines)、盒装花色品种、标准盒装花色品种、扭转包裹的微型巧克力、调味巧克力、带玩具的巧克力、夹心饼、其他巧克力糖果、薄荷糖、标准薄荷糖、强力薄荷糖、硬糖、软锭剂、口香糖、果冻和咀嚼糖、太妃糖、焦糖和牛轧糖、含药糖果、棒棒糖、甘草、其他糖果、面包、包装/工业面包、散装/手工面包、糕点、蛋糕、包装/工业蛋糕、散装/手工蛋糕、饼干、巧克力涂层饼干、夹心饼干、夹馅饼干、咸饼干和薄脆饼干、面包替代品、早餐麦片、即食麦片、家庭早餐麦片、玉米片(flakes)、什锦麦片(muesli)、其他麦片、儿童早餐麦片、热麦片、冰淇淋、即食冰淇淋、单份奶制品冰淇淋、单份水冰淇淋、多包装奶制品冰淇淋、多包装水冰淇淋、家庭装冰淇淋、家庭装奶制品冰淇淋、冰淇淋甜点、散装冰淇淋、家庭装水冰淇淋、冷冻酸奶、手工冰淇淋、乳制品、牛奶、新鲜/巴氏灭菌奶、全脂新鲜/巴氏灭菌奶、半脱脂新鲜/巴氏杀菌奶、保存期较长的/超高温奶、全脂保存期较长的/超高温奶、半脱脂保存期较长的/超高温奶、无脂保存期较长的/超高温奶、羊奶、炼乳/淡炼乳、原味炼乳/淡炼乳、调味的、功能性和其他炼乳、调味乳饮料、巧克力奶、纯乳制品风味乳饮料、果汁风味乳饮料、牛奶替代饮料,包括米浆、杏仁奶、腰果奶、椰奶、榛子奶、火麻奶、开心果奶、燕麦奶、小麦奶、大麦奶、小米奶、斯佩尔特奶、黑小麦奶和豆奶、酸乳饮料、发酵乳饮料、开菲乳、咖啡用奶精、奶粉、调味奶粉饮品、奶油、干酪、加工干酪、涂抹干酪、不易涂开的加工干酪、未加工干酪、涂抹未加工干酪、硬干酪、包装硬干酪、未包装的硬干酪、酸奶、原味/天然酸奶、调味酸奶、水果酸奶、益生菌酸奶、饮用酸奶、常规饮用酸奶、益生菌饮用酸奶、冷冻和耐储存点心、基于乳品的点心、基于大豆的甜点、冷冻点心、鲜奶酪和夸克奶酪、原味鲜奶酪和夸克奶酪、调味鲜奶酪和夸克奶酪、咸味鲜奶酪和夸克奶酪、甜味和咸味零食、水果零食、薯条/薯片、膨化休闲食品、玉米粉圆饼/玉米片、爆米花、椒盐脆饼、坚果、其他甜味和美味零食、零食棒、格兰诺拉麦片、早餐棒、能量棒、水果棒、其他零食棒、代餐、减肥产品、康复饮料、即食食品、罐头即食食品、冷冻即食食品、干燥即食食品、冷冻即食餐、晚餐混合物、冷冻比萨、冷藏比萨、汤、罐头汤、脱水汤、速溶汤、冷汤、热汤、速冻汤、意大利面、罐装意大利面、干意大利面、冷冻/新鲜的意大利面、面条、原味面条、方便面、杯装/碗装方便面、袋装方便面、冷冻面条、零食面、罐头食品、肉类和肉制品罐头、鱼/海鲜罐头、蔬菜罐头、番茄罐头、豆类罐头、水果罐头、罐装即食食品、罐头汤、罐头意大利面、其他罐头食品、冷冻食品、冷冻加工红肉、冷冻加工家禽、冷冻加工鱼/海鲜、冷冻加工蔬菜、冷冻肉类替代品、冷冻土豆、烤箱烤薯片、其他烤箱烤马铃薯产品、非烤箱冷冻土豆、冷冻烘焙食品、冷冻甜品、冷冻即食食品、冷冻比萨饼、冷冻汤、冷冻面、其他冷冻食品、干制食品、甜点混合物、干燥即食食品、脱水汤、速溶汤、干意大利面、原味面条、方便面、杯装/碗装方便面、袋装方便面、冷藏食品、冷藏加工肉类、冷藏鱼/海鲜产品、冷藏加工鱼、冷藏涂覆鱼、冷藏熏鱼、冷藏午餐包、冷藏即食食品、冷藏比萨、冷藏汤、冷藏/新鲜意大利面、冷藏面条、油和脂肪、橄榄油、植物油和种子油、烹饪脂肪、黄油、人造黄油、涂抹油和脂、功能性涂抹油和脂、酱料、调味料和调味品、番茄糊和泥、肉汤/汤料块、汤料块、肉汁颗粒、液体汤料和原料、药草和香料、发酵酱汁、大豆类酱、意大利面酱、湿酱料、干酱/粉末混合物、番茄酱、蛋黄酱、常规蛋黄酱、芥末、沙拉酱、常规沙拉酱、低脂沙拉酱、香醋沙司、蘸料、腌制品、其他酱料、调味料和调味品、婴儿食品、配方奶粉、标准配方奶粉、成长配方奶粉、幼儿配方奶粉、防过敏奶粉配方、预制婴儿食品、干制婴儿食品、其他婴儿食品、涂抹酱、果酱和蜜饯、蜂蜜、巧克力酱、坚果类涂抹酱、speculoos涂抹酱、黄油、调味黄油、人造黄油、食用油涂抹酱、液态牛油类、奶酪或奶油干酪涂抹酱、美味涂抹酱和酵母类涂抹酱。示例性的可摄取组合物还包括糖果、烘焙产品、冰淇淋、乳制品、甜味和美味零食、零食棒、代餐产品、即食食品、汤、意大利面、面条、罐头食品、冷冻食品、干食品、冷藏食品、油和脂肪、婴儿食品或涂抹食品或其混合物。示例性的可摄取组合物还包括早餐麦片、甜饮料或用于制备饮料的固体或液体浓缩物组合物,理想地是使得能够降低先前已知的糖类甜味剂或人工甜味剂的浓度。
一些实施方案提供了可吞咽或可不吞咽的可咀嚼组合物。在一些实施方案中,可咀嚼组合物可以是胶糖、口香糖、糖化胶糖、无糖胶糖、功能性胶糖、泡泡糖,其包含本文所述的风味修饰化合物和本文所述的甜味剂。
调味浓缩物制剂
在一些实施方案中,本文所述的赛门苷I组合物可以以调味浓缩物制剂的形式提供,例如适合于后续加工以生产即用型(例如,即食型)产品。“调味浓缩物制剂”是指应当用一种或多种稀释介质复原以成为即用型组合物的制剂。术语“即用型组合物”在本文中与“可摄取组合物”互换使用,其表示无论打算用于还是不用于食用,无论是单独还是与另一种物质一起可以通过口服摄取的任何物质。在一种实施方案中,即用型组合物包括可以被人或动物直接食用的组合物。调味浓缩物制剂通常通过与一种或多种稀释介质例如任何可食用或可摄取的成分或产品混合或由其稀释来使用,以将一种或多种调味剂赋予或改变稀释介质。这样的使用过程通常被称为复原。复原可以在家庭环境或工业环境中进行。例如,消费者可以在厨房中用水或其他水性介质将冷冻的果汁浓缩物复原,以获得即用型果汁饮料。在另一个例子中,软饮料糖浆浓缩物可以由制造商以大规模工业规模用水或其他水性介质进行复原,以生产即用型软饮料。由于调味浓缩物制剂具有的调味剂或调味料的浓度高于即用型组合物,因此调味浓缩物制剂通常不适合不经复原而直接食用。使用和生产调味浓缩物制剂有许多好处。例如,一个好处是减少了运输的重量和体积,因为可以在使用时通过添加合适的溶剂、固体或液体来将调味浓缩物制剂复原。
在一种实施方案中,调味浓缩物制剂包含赛门苷I和i)一种或多种如本文所述的风味修饰化合物;ii)载体;和iii)可选地至少一种佐剂。术语“载体”表示通常不活泼的辅助物质,例如溶剂、粘合剂或其他惰性介质,其与风味修饰化合物和一种或多种可选的佐剂组合使用以形成制剂。例如,水或淀粉可以是调味浓缩物制剂的载体。在一些实施方案中,载体与用于将调味浓缩物制剂复原的稀释介质相同;在其他实施方案中,载体不同于稀释介质。如本文所用,术语“载体”包括但不限于摄取上可接受的载体。
术语“佐剂”表示补充、稳定、维持或增强活性成分(例如本公开的化合物)的预期功能或有效性的添加剂。在一种实施方案中,至少一种佐剂包含一种或多种调味剂。调味剂可以具有本领域技术人员或消费者已知的任何风味,例如巧克力、咖啡、茶、摩卡、法式香草、花生酱、印度奶茶(chai),或其组合的风味。在另一种实施方案中,至少一种佐剂包含一种或多种甜味剂。一种或多种甜味剂可以是上述甜味剂中的任何一种。在另一种实施方案中,该至少一种佐剂包含一种或多种从由如下构成的群组中选出的成分:乳化剂、稳定剂、抗微生物防腐剂、抗氧化剂、维生素、矿物质、脂肪、淀粉、蛋白质浓缩物和分离物、盐、和它们的组合。乳化剂、稳定剂、抗微生物防腐剂、抗氧化剂、维生素、矿物质、脂肪、淀粉、蛋白质浓缩物和分离物以及盐的例子描述于美国专利No.6,468,576,其全部内容通过引用整体并入本文以用于所有目的。
在一种实施方案中,本发明的调味浓缩物制剂可以为选自包括溶液和悬浮液的液体、固体、泡沫材料、糊剂、凝胶、乳剂以及它们的组合的形式,例如含有一定量固体内容物的液体。在一种实施方案中,调味浓缩物制剂为包括水基和非水基的液体形式。在一些实施方案中,本发明的调味浓缩物制剂可以是碳酸化的或非碳酸化的。
调味浓缩物制剂可以进一步包含凝固点降低剂、成核剂或两者作为该至少一种佐剂。凝固点降低剂是摄取上可接受的化合物或试剂,其可以降低添加了该化合物或试剂的液体或溶剂的凝固点。即,含有凝固点降低剂的液体或溶液的凝固点比没有凝固点降低剂的液体或溶剂的凝固点低。除了降低起始凝固点之外,凝固点降低剂还可以降低调味浓缩物制剂的水活度。凝固点抑制剂的例子包括但不限于碳水化合物、油、乙醇、多元醇例如甘油以及它们的组合。成核剂表示能够促进成核的摄取上可接受的化合物或试剂。调味浓缩物制剂中成核剂的存在可以改善雪泥的口感,并通过增加所需的冰结晶中心的数量来帮助在冷冻温度下保持雪泥的物理性质和性能。成核剂的例子包括但不限于硅酸钙、碳酸钙、二氧化钛以及它们的组合。
在一种实施方案中,调味浓缩物制剂被配制为具有低水活度以延长保存期限。水活度是在相同温度下制剂中水的蒸气压与纯水的蒸气压之比。在一种实施方案中,调味浓缩物制剂的水活度小于约0.85。在另一种实施方案中,调味浓缩物制剂的水活度小于约0.80。在另一种实施方案中,调味浓缩物制剂的水活度小于约0.75。
在一种实施方案中,调味浓缩物制剂中风味修饰化合物的浓度为即用型组合物中化合物浓度的至少2倍。在一种实施方案中,调味浓缩物制剂中风味修饰化合物的浓度为即用型组合物中化合物浓度的至少5倍。在一种实施方案中,调味浓缩物制剂中风味修饰化合物的浓度为即用型组合物中化合物浓度的至少10倍。在一种实施方案中,调味浓缩物制剂中风味修饰化合物的浓度为即用型组合物中化合物浓度的至少15倍。在一种实施方案中,调味浓缩物制剂中风味修饰化合物的浓度为即用型组合物中化合物浓度的至少20倍。在一种实施方案中,调味浓缩物制剂中风味修饰化合物的浓度为即用型组合物中化合物浓度的至少30倍。在一种实施方案中,调味浓缩物制剂中风味修饰化合物的浓度为即用型组合物中化合物浓度的至少40倍。在一种实施方案中,调味浓缩物制剂中风味修饰化合物的浓度为即用型组合物中化合物浓度的至少50倍。在一种实施方案中,调味浓缩物制剂中风味修饰化合物的浓度为即用型组合物中化合物浓度的至少60倍。在一种实施方案中,调味浓缩物制剂中风味修饰化合物的浓度高达即用型组合物中的化合物浓度的100倍。
佐餐用组合物
在一些进一步的形态中,本公开提供了一种佐餐用(tabletop)甜味剂组合物,其包含:(a)至少一种根据前述形态及其实施方案中任一项的赛门苷I组合物(即,包含赛门苷I、可选的一种或多种另外的甜味剂和可选的调味修饰化合物或其食用上可接受的盐)的组合物;和(b)至少一种增量剂(bulking agent)。
佐餐用甜味剂组合物可以采取任何合适的形式,包括但不限于无定形固体、晶体、粉末、片剂、液体、立方体、糖霜或糖衣、粒状产品,围绕或包被在载体/颗粒上的包封形式,湿的或干的,或它们的组合。
佐餐用甜味剂组合物可以包含本领域技术人员已知的其他添加剂。这些添加剂包括但不限于起泡剂、增量剂、载体、纤维、糖醇、低聚糖、糖、高强度甜味剂、营养性甜味剂、调味剂、风味增强剂、风味稳定剂、酸化剂、抗结块剂和自由流动剂。此类添加剂例如描述于H.Mitchell(H.Mitchell,“Sweeteners and Sugar Alternatives in Food Technology”,Backwell Publishing Ltd.,2006,其通过引用整体并入本文)。调味剂可包括技术人员已知的那些风味剂(flavors),例如天然和人工风味剂。这些调味剂可以选自合成调味油和调味芳香物质或来自植物、叶子、花朵、果实等的油,油性树脂和提取物,以及它们的组合。非限制性的代表性风味剂油包括留兰香油、肉桂油、鹿蹄草油(水杨酸甲酯)、胡椒薄荷油、日本薄荷油、丁香油、月桂油、茴香油、桉树油、百里香油、雪松叶油、肉豆蔻油、多香果、鼠尾草油、肉豆蔻(mace)、苦杏仁油和决明子油。有用的调味剂还有人造的、天然的和合成的水果风味剂,例如香草,和柑橘油,包括柠檬、橙子、酸橙、葡萄柚、日本柚(yazu)、酢橘(sudachi),以及水果香精(essences),包括苹果、梨、桃、葡萄、蓝莓、草莓、树莓、樱桃、李子、菠萝、西瓜、杏、香蕉、甜瓜、杏、梅、樱桃、树莓、黑莓、热带水果、芒果、山竹、石榴、木瓜等。其他潜在的风味剂包括牛奶风味剂,黄油风味剂,奶酪风味剂,奶油风味剂和酸奶风味剂;香草风味剂;茶或咖啡风味剂,例如绿茶风味剂,乌龙茶风味剂,茶风味剂,可可风味剂,巧克力风味剂和咖啡风味剂;薄荷风味剂,例如胡椒薄荷风味剂,留兰香风味剂和日本薄荷风味剂;香料风味剂,例如阿魏风味剂,印度藏茴香风味剂,大茴香风味剂,当归风味剂,茴香风味剂,多香果风味剂,肉桂风味剂,甘菊风味剂,芥末风味剂,小豆蔻风味剂,香菜风味剂,小茴香风味剂,丁香风味剂,胡椒风味剂,胡荽风味剂,黄樟风味剂,咸味风味剂,川椒风味剂,紫苏风味剂,杜松子风味剂,生姜风味剂,八角茴香风味剂,辣根风味剂,百里香风味剂,龙蒿风味剂,莳萝风味剂,菜椒风味剂,肉豆蔻风味剂,罗勒风味剂,马郁兰风味剂,迷迭香风味剂,月桂叶风味剂和芥末(日本辣根)风味剂;酒香风味剂,例如红酒风味剂,威士忌风味剂,白兰地风味剂,朗姆酒风味剂,杜松子酒风味剂和利口酒风味剂;花香风味剂;以及蔬菜风味剂,例如洋葱风味剂,大蒜风味剂,卷心菜风味剂,胡萝卜风味剂,芹菜风味剂,蘑菇风味剂,和番茄风味剂。这些调味剂可以液体或固体形式使用,并且可以单独或混合使用。常用的风味剂包括薄荷,例如胡椒薄荷、薄荷醇、留兰香、人造香草、肉桂衍生物以及各种水果风味剂,无论是单独使用还是混合使用。风味剂还可以提供口气清新的特性,特别是与清凉剂结合使用时的薄荷风味剂。
风味剂还可以提供口气清新的特性,特别是与清凉剂结合使用时的薄荷风味剂。这些调味剂可以以液体或固体形式使用,并且可以单独或混合使用。其他有用的调味剂包括醛和酯,例如乙酸肉桂酯、肉桂醛、柠檬醛二乙基乙缩醛、乙酸二氢香芹酯、甲酸丁香酚酯、对甲基茴香醚等。通常,可以使用任何调味剂或食品添加剂,例如由美国国家科学院(National Academy ofSciences)在Chemicals Used in Food Processing,publication1274,pages 63-258中所述的那些。该出版物通过引用并入本文。
醛调味剂的其他例子包括但不限于乙醛(苹果),苯甲醛(樱桃、杏仁),茴香醛(甘草、茴香),肉桂醛(肉桂),柠檬醛,即α-柠檬醛(柠檬,酸橙),橙花醛,即β-柠檬醛(柠檬、酸橙),癸醛(橙、柠檬),乙基香草醛(香草、奶油),洋茉莉醛,即胡椒醛(香草、奶油),香草醛(香草、奶油),α-戊基肉桂醛(辛辣的果味风味剂),丁醛(黄油、奶酪),戊醛(黄油、奶酪),香茅醛(改性产物、多种类型),癸醛(柑橘类水果),醛C-8(柑橘类水果),醛C-9(柑橘类水果),醛C-12(柑橘类水果),2-乙基丁醛(浆果),己烯醛,即反式-2(浆果),甲苯基甲醛(樱桃、杏仁),藜芦醛(香草),2,6-二甲基-5-庚烯,即甜瓜醛(甜瓜),2,6-二甲基辛醛(绿色水果),和2-十二碳烯醛(柑橘、桔),樱桃,葡萄,草莓酥饼,以及它们的混合物。这些调味剂的列表仅是示例性的,并不意味着通常限制术语“调味物质”或“调味剂”或一般公开的范围。
在一些实施方案中,调味剂可以以液体形式和/或干燥形式使用。当以后一种形式使用时,可以使用合适的干燥手段,例如将油喷雾干燥。或者,可以将调味剂吸收到水溶性材料上,例如纤维素、淀粉、糖、麦芽糊精、阿拉伯胶等,或者可以将其包封。制备这种干燥形式的技术是众所周知的。
在一些实施方案中,可将佐餐用甜味剂制成类似于红糖。在这样的实施方案中,可以将赋予红糖(brown)香调的化合物添加到组合物中以使其味道更类似于红糖。
在一些实施方案中,调味剂可以以本领域众所周知的许多不同的物理形式使用,以提供初始的风味迸发和/或延长的风味感觉。不限于此,这些物理形式包括游离形式,例如喷雾干燥、粉末状、珠状形式、包封形式以及它们的混合形式。
合适的增量剂包括但不限于麦芽糊精(10DE、18DE或5DE)、玉米糖浆固体(20或36DE)、蔗糖、果糖、葡萄糖、转化糖、山梨糖醇、木糖、核糖、甘露糖、木糖醇、甘露糖醇、半乳糖醇、赤藓糖醇、麦芽糖醇、乳糖醇、异麦芽酮糖醇、麦芽糖、塔格糖、乳糖、菊粉、甘油、丙二醇、多元醇、聚葡萄糖、低聚果糖、纤维素和纤维素衍生物等,以及它们的混合物。此外,砂糖(蔗糖)或其他有热量甜味剂(例如结晶果糖、其他碳水化合物或糖醇)可以用作增量剂,因为它们提供了良好的含量均匀性而又不增加明显的卡路里。
在一种实施方案中,至少一种增量剂可以是美国专利号8,993,027中描述的增量剂,该专利的公开内容通过引用整体并入。
在一种实施方案中,至少一种增量剂可以是美国专利号6,607,771中描述的增量剂,该专利的公开内容通过引用整体并入。
在一种实施方案中,至少一种增量剂可以是美国专利号6,932,982中描述的增量剂,该专利的公开内容通过引用整体并入。
在一些实施方案中,佐餐用甜味剂组合物可以进一步包含至少一种抗结块剂。如本文所用,短语“抗结块剂”和“流动剂”是指防止、减少、抑制或压制至少一种甜味剂与另一种甜味剂分子附接、结合或接触的任何组合物。或者,抗结块剂可以指有助于含量均匀性和均匀溶解的任何组合物。抗结块剂的非限制性例子包括塔塔粉(cream of tartar)、硅酸钙、二氧化硅、微晶纤维素(Avicel,FMC BioPolymer,宾夕法尼亚州费城)和磷酸三钙。在一种实施方案中,抗结块剂在佐餐用甜味剂组合物中的存在量为佐餐用甜味剂组合物重量的约0.001%至约3%。
在一些实施方案中,前述形态和其实施方案中任一项的甜味剂组合物使用用于包封调味剂或香氛(fragrance)化合物的典型方法来包封。此类技术的非限制性例子描述于美国专利申请公开号2016/0235102、2019/0082727、2018/0369777、2018/0103667、2016/0346752、2015/0164117、2014/0056836、2012/0027866、2010/0172945和2007/0128234,以及美国专利号7,488,503、6,416,799、5,897,897、5,786,017、5,603,971、4,689,235、4,610,890、3,704,137、3,041,180和2,809,895。所有先前的专利出版物和专利均通过引用并入本文,如同其全部内容在本文中阐述一样。
实施例
实施例1:苹果饮料的感官测试
一组志愿者以10分制评估了赛门苷I的口腔内属性(甜度、延迟甜度、酸味、苦味、总体风味强度、稠度/醇厚感(body)和涩味)以及余味(AT)属性(持久的甜度、总体异味强度、甘草异味、苦味异味和口腔包覆感(mouth coating))。进行了两次重复品鉴(session),两次品鉴之间有20分钟的休息时间。一次品鉴中的样本之间存在90秒的延迟。小组成员在第一次品鉴中评估了所有样品,并在第二次品鉴中再次评估了这些样品。在所有品鉴中对莱鲍迪苷M(Reb M)对照样品进行评估作为对照。还评估了罗汉果苷V,并提供了罗汉果苷V的感官数据。
使用2路方差分析(ANOVA)并使用Tukey’s HSD测试进行交互来进行数据分析。根据Reb M的平均得分对每种属性的数据进行归一化。
含赛门苷I的苹果饮料的口腔内属性
含赛门苷I的苹果饮料的每种样品的平均归一化口腔内属性评估如下。
含赛门苷I的苹果饮料的余味属性
含赛门苷I的苹果饮料的每种样品的平均甜度评估如下。
赛门苷I的口腔内和余味概貌与苹果饮料中的Reb M相当。还发现与罗汉果苷V相比,赛门苷I更甜,总体风味强度更高,同时总体异味也更低。
实施例2:柠檬酸橙碳酸软饮料的感官测试
一组志愿者根据上面实施例1中描述的方法评估了含赛门苷I的柠檬酸橙碳酸软饮料的口腔内属性和余味属性。
含赛门苷I的柠檬酸橙碳酸软饮料的口腔内属性
含西拉糖的柠檬酸橙碳酸软饮料样品的平均归一化口腔内属性评估如下。
含赛门苷I的柠檬酸橙碳酸软饮料的余味属性
含赛门苷I的柠檬酸橙碳酸软饮料样品的平均归一化余味属性评估如下。
甜味剂 | 持久的甜度 | 总体异味 | 甘草余味 | 苦味余味 |
600ppm的赛门苷I | 4.4 | 4.1 | 3.0 | 1.3 |
600mg的罗汉果苷V | 3.6 | 3.7 | 2.3 | 1.6 |
600ppm的Reb M | 4.3 | 3.6 | 2.5 | 1.4 |
赛门苷I的口腔内和余味概貌与柠檬酸橙碳酸软饮料中的Reb M相当。浓度为600ppm时,赛门苷I具有与Reb M相同的甜度和整体风味强度,同时总体苦味较低。与罗汉果苷V相比,赛门苷I还具有更高的甜度、更低的苦味和更高的总体风味强度,同时具有更低的苦味余味。
实施例3:起泡橙味饮料的感官测试
一组志愿者根据上面实施例1中描述的方法评估了含赛门苷I的起泡橙味饮料的口腔内属性和余味属性。
起泡橙味饮料的口腔内属性
评估了含赛门苷I的起泡橙味饮料样品的平均归一化口腔内属性,结果提供如下。
甜味剂 | 甜度 | 延迟甜度 |
250ppm的赛门苷I | 5.9 | 3.7 |
250mg的罗汉果苷V | 5.1 | 4.2 |
250ppm的Reb M | 5.8 | 3.3 |
余味属性
评估了含赛门苷I的起泡橙味饮料样品的平均归一化余味属性,结果提供如下。
甜味剂 | 持久的甜度 | 总体异味 | 甘草余味 | 口腔包覆感 |
250ppm的赛门苷I | 4.4 | 3.6 | 2.8 | 2.9 |
250mg的罗汉果苷V | 3.6 | 2.9 | 2.2 | 2.8 |
250ppm的Reb M | 3.9 | 3.3 | 2.2 | 2.5 |
赛门苷I的口腔内和余味概貌与橙味起泡饮料中的Reb M相当,表现出略高的甜度和延迟甜度。与罗汉果苷V相比,赛门苷I的甜度也更高。
实施例4:香草奶的感官测试
一组志愿者根据上面实施例1中描述的方法评价了香草奶的口腔内属性和余味属性。
口腔内属性
评估了每种香草奶样品的平均归一化口腔内属性,结果提供如下。
香草奶的余味属性
评估了含赛门苷I的香草奶的每种样品的平均归一化余味属性,结果提供如下。
甜味剂 | 持久的甜度 | 总体异味 | 甘草余味 | 口腔包覆感 |
200ppm的赛门苷I | 3.3 | 1.8 | 1.2 | 3.3 |
200mg的罗汉果苷V | 2.5 | 1.6 | 0.8 | 2.9 |
200ppm的Reb M | 2.6 | 1.8 | 0.8 | 3.1 |
400ppm的赛门苷I | 4.8 | 2.4 | 1.7 | 0.5 |
400mg的罗汉果苷V | 3.5 | 2.2 | 1.1 | 0.9 |
400ppm的Reb M | 3.8 | 2.1 | 1.3 | 0.7 |
与200ppm和400ppm的香草奶中的Reb M相比,赛门苷I显示出增加的甜度和持久的甜度,同时具有类似的口腔内概貌。与罗汉果苷V相比,赛门苷I还具有更高的甜度和延迟甜度,同时具有更高的总体风味强度和更低的苦味。
实施例5:柠檬味饮料的附加感官测试
三个地点的调味师小组以0~10分制评估了浓度为600ppm罗汉果苷的各种罗汉果苷的柠檬酸橙饮料的口腔内属性(峰值甜度、前期甜度、苦味和口感/稠度)和余味属性(持久甜味)。口腔内属性是在将样品含在口中时评估的,而余味属性是在吐出后评估的。使用邓肯的新多重范围测试对数据进行分析,分数(紧凑字母表示)提供在下面的数据中的括号中。
甜味剂 | 峰值甜度 | 前期甜度 | 苦味 | 持久甜味 | 口感/稠度 |
西拉糖 | 8.429(a) | 6.571(a) | 1.357(a) | 6.143(a) | 4.143(a) |
赛门苷I | 6.571(b)_ | 4.286(b) | 2.571(a) | 4.429(bc) | 3.429(ab) |
异罗汉果苷V | 5.571(bc) | 4.000(b) | 2.286(a) | 4.857(ab) | 2.571(b) |
异罗汉果苷IVE | 4.857(c) | 3.571(b) | 1.857(a) | 3.429(c) | 2.714(b) |
实施例6:香草奶的附加感官测试
三个地点的调味师小组以0~10分制评估了含有浓度为400ppm罗汉果苷的各种罗汉果苷的香草奶的口腔内属性(峰值甜度、前期甜度、苦味和口感/稠度)和余味属性(持久甜味)。口腔内属性是在将样品含在口中时评估的,而余味属性是在吐出后评估的。使用邓肯的新多重范围测试对数据进行分析,分数提供在下面的数据中的括号中。
甜味剂 | 峰值甜度 | 前期甜度 | 苦味 | 持久甜味 | 口感/稠度 |
西拉糖 | 8.000(a) | 6.625(a) | 1.750(a) | 6.375(a) | 5.375(a) |
赛门苷I | 7.375(a)_ | 5.938(ab) | 1.688(a) | 5.875(a) | 5.000(ab) |
异罗汉果苷V | 6.188(b) | 5.125(b) | 0.875(b) | 4.625(b) | 4.875(ab) |
异罗汉果苷IVE | 5.938(c) | 5.125(b) | 1.313(ab) | 4.563(b) | 4.125(b) |
关于实施例4和实施例5,专家小组成员指出,发现与甜叶菊相比,西拉糖、赛门苷I、异罗汉果苷V和异罗汉果苷IVE各自具有较低的甘草余味和较低的苦味余味,同时具有更好的口感。
给出前述详细描述只是为了清楚理解,而不应从中理解不必要的限制,因为修改对于本领域技术人员来说是显而易见的。并不承认本文提供的任何信息是现有技术或与当前要求保护的实施方案相关,也不承认明确引用或隐含引用的任何出版物是现有技术。
Claims (14)
1.一种制剂,包含赛门苷I;以及如下的至少一种或多种:(i)一种或多种另外的甜味剂;(ii)一种或多种调味修饰化合物;或(iii)调味剂。
2.根据权利要求1所述的制剂,其中该一种或多种另外的甜味剂是从由如下构成的群组中选出的:龙舌兰菊粉、龙舌兰花蜜、龙舌兰糖浆、日本甘酒、布拉齐因、糙米糖浆、椰子晶体、椰子糖、椰子糖浆、枣糖、果聚糖(也称为菊粉纤维、果糖低聚糖或低聚果糖)、绿色甜菊粉、甜叶菊、莱鲍迪苷A、莱鲍迪苷B、莱鲍迪苷C、莱鲍迪苷D、莱鲍迪苷E、莱鲍迪苷F、莱鲍迪苷I、莱鲍迪苷H、莱鲍迪苷L、莱鲍迪苷K、莱鲍迪苷J、莱鲍迪苷N、莱鲍迪苷O、莱鲍迪苷M和其他甜叶菊基糖苷、甜菊苷、甜菊苷提取物、蜂蜜、菊芋糖浆、甘草根、罗汉果(果实、粉末或提取物)、蛋黄果(果实、粉末或提取物)、枫树树液(包括例如从糖枫、黑枫、美国红枫、银枫、挪威枫、梣叶槭、大叶枫、粗齿枫、落基山枫、色木槭提取的树液)、枫树糖浆、枫糖、胡桃树液(包括例如从白胡桃、黑胡桃、鬼胡桃、胡桃提取的树液)、桦树树液(包括例如从纸桦、加拿大黄桦、山桦、河桦、灰色桦木、垂枝桦提取的树液)、美国梧桐树液(例如从一球悬铃木提取的树液)、铁木树液(例如从美洲铁木提取的树液)、未精制蔗糖、糖蜜(举例而言例如黑糖蜜)、糖蜜糖、莫纳甜、莫奈林、甘蔗糖(也称为天然糖、未精制苷蔗糖或蔗糖)、棕榈糖、墨西哥粗糖、墨西哥粗糖条、红糖砖、原糖、大米糖浆、高粱、高粱糖浆、木薯糖浆(也称为木薯淀粉糖浆)、奇异果甜蛋白、雪莲果、麦芽糖浆、大麦麦芽糖浆、大麦麦芽粉、甜菜糖、甘蔗糖、结晶果汁结晶、焦糖、卡必醇、角豆糖浆、蓖麻糖、氢化淀粉水纯露、水解的罐装果汁、水解淀粉、转化糖、茴香脑、阿拉伯半乳聚糖、浓缩葡萄汁、糖浆、P-4000、乙酰磺胺酸钾(也称为乙酰舒泛钾或ace-K)、阿力甜(也称为阿力糖)、爱德万甜、阿斯巴甜、白云参苷、纽甜、苯甲酰胺衍生物、bernadame、canderel、carrelame和其他胍基甜味剂、植物纤维、玉米糖、偶联糖、仙茅甜蛋白、环己氨基磺酸盐、青钱柳苷I、德梅拉拉糖、葡聚糖、糊精、糖化麦芽、甘素、甜精、乙氧基苯脲、杜尔可苷A、杜尔可苷B、艾木林、甘草次酸、麦芽糊精、糖精、草蒿脑、乙基麦芽酚、羟苯基甘胺酸、葡萄糖酸、葡萄糖酸内酯、葡糖胺、葡萄糖醛酸、甘油、甘氨酸、glycyphillin、甘草甜素、甘草次酸单葡糖醛酸化物、金黄糖、黄糖、金黄糖浆、砂糖、绞股蓝、贺兰甜精、异构化液体糖、jallab、菊苣根膳食纤维、犬尿氨酸衍生物(包括N'-甲酰基-犬尿氨酸、N'-乙酰基-犬尿氨酸、6-氯-犬尿氨酸)、半乳糖醇、利体素、健美原蔗金砂糖、利卡新、N-(4-氰基苯基)-N-(2,3-亚甲二氧苄基)胍乙酸、胍、法勒南糖浆、马槟榔甜蛋白I、马槟榔甜蛋白II、麦芽酚、结晶麦芽糖醇、麦芽糊精、麦芽三糖醇、甘露糖胺、神秘果蛋白、水饴、其他罗汉果苷(包括例如罗汉果苷IV、罗汉果苷V、新罗汉果苷、西拉糖和异罗汉果苷IVE)、无患子倍半萜苷、纳米糖、柚皮苷二氢查尔酮、新橙皮苷二氢查尔酮、粗糖、黑寡糖、诺布糖、杏仁糖浆、欧亚水龙骨甜素、派克梅兹、潘塔亭、巴西甘草甜素I、紫苏醛、紫苏葶、petphyllum、苯丙氨酸、假秦艽苷I、根皮素、phlorodizin、叶甜素、氢化葡萄糖浆、多足蕨苷A、蝶卡苷A、蝶卡苷B、润贝安娜、精制糖浆、摩擦糖浆、甜叶悬钩子苷、蓨蕨素A、舒格糖、赛门苷I、罗汉果、大豆低聚糖、善品糖、SRIoxime V、甜菊醇糖苷、甜菊醇双糖苷、甜菊苷、叉柱花素1、2和4、蔗糖酸、sucrononate、糖、对硝基苯基脲基丙酸钠、根皮苷、超级阿斯巴甜、四糖、苏糖醇、糖蜜、三叶苷、色氨酸及衍生物(6-三氟甲基-色氨酸、6-氯-D-色氨酸)、香草糖、庚七醇、桦树糖浆、阿斯巴甜-乙酰磺胺酸、艾苏格、以及它们任意两种或更多种的组合或共混物。
3.根据权利要求1或权利要求2所述的制剂,其中该一种或多种风味修饰化合物是:
或其盐或溶剂化物;或它们的任意组合,可选地与一种或多种另外的风味修饰化合物组合。
4.根据权利要求1至3中任一项所述的制剂,其是可摄取组合物。
5.根据权利要求4所述的可摄取组合物,其呈食物或饮料产品、动物饲料产品、药物组合物、营养产品、膳食补充剂或非处方药物的形式。
6.根据权利要求5所述的可摄取组合物,其中该食物或饮料产品供人或动物食用。
7.根据权利要求6所述的可摄取组合物,其中该饮料是从由如下构成的群组中选出的:起泡饮料、果汁、水果味果汁、果汁饮料、蜜汁饮料、蔬菜汁、蔬菜味汁、运动饮料、能量饮料、强化水饮料、含维生素强化水、近水饮料、椰子水、茶类饮料、咖啡、可可饮料、含奶成分的饮料、奶替代品饮料、含谷物提取物的饮料和冰沙。
8.根据权利要求6所述的可摄取组合物,其中该饮料产品包含:
柠檬酸、磷酸、抗坏血酸、硫酸氢钠、乳酸和/或酒石酸;
咖啡因、奎宁、绿茶、儿茶素、多酚、罗布斯塔咖啡生豆提取物、咖啡生豆提取物、乳清分离蛋白和/或氯化钾;
焦糖色、红色#40、黄色#5、黄色#6、蓝色#1、红色#3、紫色胡萝卜、黑色胡萝卜汁、紫色地瓜、蔬菜汁、果汁、β-胡萝卜素、姜黄姜黄素和/或二氧化钛;
苯甲酸钠、苯甲酸钾、山梨酸钾、偏亚硫酸氢钠、山梨酸和/或苯甲酸;
抗坏血酸、EDTA钙二钠、α-生育酚、混合生育酚、迷迭香提取物、葡萄籽提取物、白藜芦醇和/或六偏磷酸钠;
白藜芦醇、Co-Q10、ω3脂肪酸、茶氨酸、氯化胆碱(胞磷胆碱)、善倍素、菊粉(菊苣根)、牛磺酸、人参提取物、瓜拉那提取物、生姜提取物、L-苯丙氨酸、L-肉碱、L-酒石酸盐、D-葡萄糖醛酸内酯、肌醇、生物类黄酮、紫锥菊、银杏、马黛茶、亚麻籽油、藤黄果皮提取物、白茶提取物、核糖、奶蓟草提取物、葡萄籽提取物、盐酸吡多醇(维生素B6)、氰钴胺(维生素B12)、烟酰胺(维生素B3)、生物素、乳酸钙、泛酸钙(泛酸)、磷酸钙、碳酸钙、氯化铬、多烟酸铬、硫酸铜、叶酸、焦磷酸铁、铁、乳酸镁、碳酸镁、硫酸镁、磷酸一钾、磷酸一钠、磷、碘化钾、磷酸钾、核黄素、硫酸钠、葡萄糖酸钠、聚磷酸钠、碳酸氢钠、硫胺素单硝酸盐、维生素D3、维生素A棕榈酸酯、葡萄糖酸锌、乳酸锌,和/或硫酸锌;
木犀草素、芹菜素、橘皮素、槲皮素、山柰酚、杨梅素、漆黄素、高良姜素、异鼠李素、藿香黄酮醇、鼠李秦素、猫尾草异黄酮、二-O-甲基猫尾草异黄酮、4'-甲基-猫尾草异黄酮、5,3',4'-三羟基-2",2"-二甲基吡喃并(5",6":7,8)异黄酮、水黄皮色原烯、花旗松素(或二氢槲皮素)、二氢山柰酚、呋喃黄酮醇、橙皮素、柚皮素、圣草酚、高圣草酚、儿茶素、没食子儿茶素(GC)、儿茶素3-没食子酸酯(Cg)、没食子儿茶素3-没食子酸酯、表儿茶素、表没食子儿茶素(EGC)、表儿茶素3-没食子酸酯、表没食子儿茶素3-没食子酸酯、茶黄素、原花青素、2R,3R-香橙素-3-O-乙酸酯、4'-甲氧基二氢槲皮素-3-O-乙酸酯、甜橙黄酮、六甲氧基栎草亭、川陈皮素、5,6,7-三甲氧基-2-(4-甲氧基苯基)-4H-苯并吡喃-4-酮、七甲氧基黄酮和/或桔皮素;
酯胶、溴化植物油(BVO)或乙酸异丁酸蔗糖酯(SAIB);柠檬酸钠、柠檬酸钾、和/或盐;
丙二醇、乙醇、甘油、阿拉伯胶(金合欢胶)、麦芽糊精、改性玉米淀粉、右旋糖、天然调味料、具有其他天然调味料的天然调味料(天然调味料WONF)、天然和人工调味料、人工调味料、二氧化硅、碳酸镁、或磷酸三钙;或者
果胶、黄原胶、羧甲基纤维素(CMC)、聚山梨酯60、聚山梨酯80、中链甘油三酸酯、纤维素凝胶、纤维素胶、酪蛋白酸钠、改性食品淀粉、阿拉伯胶(金合欢胶)、和/或角叉菜胶;
或它们的任意组合。
9.根据权利要求1至8中任一项所述的制剂,其中该制剂增强了该另外的甜味剂和/或风味调节剂的甜度。
10.根据权利要求1至9中任一项所述的制剂,其中赛门苷I以1ppm至1000ppm的量存在。
11.根据权利要求1至9中任一项所述的制剂,其中赛门苷I以50ppm或更少的量存在。
12.根据权利要求1至9中任一项所述的制剂,其中赛门苷I以25ppm或更少的量存在。
13.根据权利要求1至12中任一项所述的制剂,其中该风味修饰化合物是减少酸味、减少甘草味道、阻断苦味、增强鲜味、增强咸味、增强清凉效果或前述的任意组合的化合物。
14.根据权利要求1至13中任一项所述的制剂,其中该风味修饰化合物是增强甜度的化合物。
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PCT/US2022/070188 WO2022155668A1 (en) | 2021-01-15 | 2022-01-13 | Sweetener compostions comprising siamenoside i and uses thereof |
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