CN116966232A - Traditional Chinese medicine composition for treating phlegm-heat accumulated lung syndrome community-acquired pneumonia and application thereof - Google Patents
Traditional Chinese medicine composition for treating phlegm-heat accumulated lung syndrome community-acquired pneumonia and application thereof Download PDFInfo
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- CN116966232A CN116966232A CN202311193576.XA CN202311193576A CN116966232A CN 116966232 A CN116966232 A CN 116966232A CN 202311193576 A CN202311193576 A CN 202311193576A CN 116966232 A CN116966232 A CN 116966232A
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Abstract
The application relates to a traditional Chinese medicine composition for treating community-acquired pneumonia with syndrome of phlegm-heat accumulating in lung, which is prepared from the following raw materials in parts by weight: 11-19 parts of dyers woad leaf, 11-19 parts of honeysuckle, 2-10 parts of mugwort leaf, 2-10 parts of cassia twig, 5-13 parts of earthworm, 5-13 parts of Chinese angelica and 8-16 parts of radix scrophulariae. Clinically, the formula of the application has better treatment effect on the community-acquired pneumonia with the syndrome of phlegm-heat accumulated in the lung by combining with the conventional western medicine treatment, has no adverse reaction, and is also suitable for treating various pulmonary diseases with symptoms of repeated cough, excessive phlegm, asthma attack and fever or fever.
Description
Technical Field
The application relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating community-acquired pneumonia with phlegm-heat accumulating in lung and application thereof.
Background
Community-acquired-pneumonitis (CAP) refers to an infectious lung parenchyma inflammation that is developed outside a hospital and is caused by a variety of microorganisms such as bacteria, viruses, chlamydia, and mycoplasma. The main clinical symptoms are cough, with or without expectoration and chest pain, and the precursor symptoms mainly comprise rhinitis-like symptoms or symptoms of upper respiratory tract infection, such as nasal obstruction, nasal discharge, sneeze, dry throat, pharyngalgia, pharyngeal foreign body sensation, hoarseness, headache, dizziness, eye thermal expansion, lacrimation, mild cough and the like. Elderly patients more often show blurred consciousness or exacerbation of existing disease, usually without chest signs or fever.
In traditional Chinese medicine, there is no disease name of 'community-acquired pneumonia', but there is a disease of wind-warm disease recorded in the theory of typhoid fever, and the disease of 'fever and thirst without aversion to cold' is a warm disease, and if sweating is already, the disease is scorched, the disease is named wind-warm disease. "in the exogenous febrile disease (Cold) Ten: wind-warm syndrome is the disease, and is the most prevalent in spring and month and winter. Or aversion to wind or no aversion to wind, cough with polydipsia due to fever, and the outline of wind-warm syndrome. "Su Wen-thorn Heat" say: the patients with lung heat are firstly and gradually syncoped, and have vellus hair, aversion to wind-cold and yellow tongue. Fever, struggle with heat, dyspnea and cough, pain going through the chest and back, and headache. It can be seen that the symptoms of fever, cough, chest pain, etc. are similar to those of lung heat disease and wind-warm disease. Studies show that the phlegm-heat obstructing lung syndrome of wind-warm lung-heat disease has the most close relationship with the inflammatory index of patients, and the phlegm-heat obstructing lung syndrome refers to the excessive heat syndrome of lung channel caused by the accumulation of phlegm-heat in the lung and the failure of the lung to disperse and descend. Also known as phlegm-heat obstructing the lung. Clinically, cough, yellow and thick sputum with excessive quantity, chest distress, dyspnea with rough breath, even nasal flaring, or wheezing in the throat, dysphoria, fever and thirst, or cough with purulent, bloody and odorous sputum, chest pain, constipation, scanty and reddish urine, red tongue with yellow and greasy coating, slippery and rapid pulse.
At present, the general rule of traditional Chinese medicine treatment for CAP patients is clearing heat and detoxicating, ventilating lung and resolving phlegm, and the documents (Chen Zhi, chen Biha, yuan Lili, etc.) disclose the following formula in the observation of the curative effect of Jiawei Maxingshi Ganman decoction for treating community-acquired pneumonia (phlegm-heat obstructing lung) [ J ]. Chinese traditional Chinese medicine emergency, 2010 (05): 725-726): the flavored sesame-apricot-licorice decoction has definite curative effect on treating the disease and can reduce the level of inflammatory factors. Another document (Zhengling, fangqiang, lianhua qingwen granule for treating 46 cases of phlegm-heat obstructing lung type community-acquired pneumonia [ J ]. Zhejiang J.Chinese medicine, 2013 (11): 1) discloses that the use of Lianhua qingwen granule for treating the phlegm-heat obstructing lung type community-acquired pneumonia has a treatment effect on the basis of the conventional Western medicine treatment.
Because community-acquired pneumonia is still a disease with high morbidity and mortality at present and seriously affects the physical health of people, the development of more drugs effective for the disease is very necessary, and the traditional Chinese medicine composition for treating community-acquired pneumonia with phlegm-heat accumulating in lung and the application of the traditional Chinese medicine composition are not reported at present.
Disclosure of Invention
The application aims at providing a traditional Chinese medicine composition for treating community-acquired pneumonia, aiming at the defects in the prior art.
A second object of the present application is to provide a pharmaceutical composition for the treatment of community-acquired pneumonia
The third object of the application is to provide an application of the traditional Chinese medicine composition.
In order to achieve the first object, the application adopts the following technical scheme:
a traditional Chinese medicine composition for treating community-acquired pneumonia is prepared from the following raw materials in parts by weight: 11-19 parts of dyers woad leaf, 11-19 parts of honeysuckle, 2-10 parts of mugwort leaf, 2-10 parts of cassia twig, 5-13 parts of earthworm, 5-13 parts of Chinese angelica and 8-16 parts of radix scrophulariae.
As a preferred example, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 13-17 parts of dyers woad leaf, 13-17 parts of honeysuckle, 4-8 parts of mugwort leaf, 4-8 parts of cassia twig, 7-11 parts of earthworm, 7-11 parts of Chinese angelica and 10-14 parts of radix scrophulariae.
More preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 parts of dyers woad leaf, 15 parts of honeysuckle, 6 parts of mugwort leaf, 6 parts of cassia twig, 9 parts of earthworm, 9 parts of Chinese angelica and 12 parts of figwort.
More preferably, the traditional Chinese medicine composition is a foot bath traditional Chinese medicine composition.
More preferably, the foot bath composition is used by the following method: weighing the raw materials according to the weight proportion of any one of claims 1-3, decocting with water, performing foot bath, adjusting the water temperature to about 40 ℃ before sleeping for 30 minutes every day, and soaking for 20 minutes.
In order to achieve the second purpose, the application adopts the following technical scheme:
the pharmaceutical composition comprises western medicines and any one of the traditional Chinese medicine compositions, wherein the western medicines are levofloxacin sodium chloride injection and ambroxol hydrochloride capsules.
In order to achieve the third object, the present application adopts the following technical scheme:
the application of any one of the traditional Chinese medicine composition or the pharmaceutical composition in preparing medicines for treating community-acquired pneumonia.
As a preferred example, the community-acquired pneumonia is of the type of phlegm-heat-accumulated lung.
The compatibility of the application is as follows:
the application mainly treats the symptoms: syndrome of phlegm-heat accumulating in the lung; efficacy: clearing lung-heat, resolving phlegm, relieving asthma and dredging collaterals; and (3) square solution: fang Zhongjin flos Lonicerae has sweet and cold nature, and is effective in dispersing and dispelling heat, and penetrating heat to reach the surface; the dyers woad leaf is bitter and cold, can purge fire and cool blood, and can clear heat toxin in nutrient blood, is matched with honeysuckle to supplement each other, enhances the effects of clearing heat and detoxicating, and is ice-cold and directly folded, so that the dyers woad leaf is taken as a monarch drug; the radix scrophulariae is cold but not drastic, moist but not greasy, discharges and descends, can clear and tonify kidney yin, can treat lung and heat, detoxicate and eliminate fire, and is a ministerial drug; dang Gui can promote blood circulation and regulate nutrient, and can treat cough with dyspnea; lumbricus, pheretima, as an adjuvant drug, clears away heat and unblocks the flow of qi, relieves asthma and cough. The yin-blood-replenishing herbs are mostly greasy, cold and cool, and are not easy to be done, so the Chinese mugwort leaf and the cassia twig are used for activating yang and harmonizing pulse and dispelling phlegm and turbid waste heat; the whole formula has orderly principal and subordinate aspects, is suitable for moistening dryness, dredging blood vessels, moistening but not greasy, and eliminating dryness from damaging body fluids.
Detailed Description
The application is further described below in conjunction with the detailed description. It is to be understood that these examples are illustrative of the present application and are not intended to limit the scope of the present application. Further, it is understood that various changes and modifications of the present application may be made by those skilled in the art after reading the description of the present application, and such equivalents are intended to fall within the scope of the application as defined in the appended claims. Unless otherwise indicated, the technical means used in the examples are conventional means well known to those skilled in the art and commercially available usual instruments and reagents, and can be referred to in the molecular cloning test guidelines (3 rd edition) (scientific press), microbiological tests (4 th edition) (higher education press) and manufacturer specifications of the corresponding instruments and reagents.
EXAMPLE 1A Chinese medicinal composition of the application
15 parts of dyers woad leaf, 15 parts of honeysuckle, 6 parts of mugwort leaf, 6 parts of cassia twig, 9 parts of earthworm, 9 parts of Chinese angelica and 12 parts of figwort.
EXAMPLE 2A Chinese medicinal composition of the application (II)
15 parts of dyers woad leaf, 13 parts of honeysuckle, 8 parts of mugwort leaf, 2 parts of cassia twig, 13 parts of earthworm, 9 parts of Chinese angelica and 10 parts of figwort.
EXAMPLE 3 Chinese medicinal composition of the application (III)
13 parts of dyers woad leaf, 17 parts of honeysuckle, 2 parts of mugwort leaf, 10 parts of cassia twig, 9 parts of earthworm, 7 parts of Chinese angelica and 14 parts of figwort.
EXAMPLE 4 Chinese medicinal composition of the Invention (IV)
17 parts of dyers woad leaf, 11 parts of honeysuckle, 10 parts of mugwort leaf, 6 parts of cassia twig, 7 parts of earthworm, 11 parts of Chinese angelica and 8 parts of figwort.
EXAMPLE 5A Chinese medicinal composition of the present application (five)
11 parts of dyers woad leaf, 19 parts of honeysuckle, 6 parts of mugwort leaf, 4 parts of cassia twig, 11 parts of earthworm, 5 parts of Chinese angelica and 16 parts of figwort.
EXAMPLE 6 Chinese medicinal composition of the present application (six)
19 parts of dyers woad leaf, 15 parts of honeysuckle, 4 parts of mugwort leaf, 8 parts of cassia twig, 5 parts of earthworm, 13 parts of Chinese angelica and 12 parts of figwort.
EXAMPLE 7 Chinese medicinal composition of the application (seven)
15 parts of dyers woad leaf, 17 parts of honeysuckle, 2 parts of mugwort leaf, 10 parts of cassia twig, 9 parts of earthworm, 7 parts of Chinese angelica and 14 parts of figwort.
EXAMPLE 8A Chinese medicinal composition (eight) of the application
13 parts of dyers woad leaf, 11 parts of honeysuckle, 10 parts of mugwort leaf, 6 parts of cassia twig, 7 parts of earthworm, 11 parts of Chinese angelica and 8 parts of figwort.
EXAMPLE 9 Chinese medicinal composition of the application (nine)
17 parts of dyers woad leaf, 19 parts of honeysuckle, 6 parts of mugwort leaf, 4 parts of cassia twig, 11 parts of earthworm, 5 parts of Chinese angelica and 16 parts of figwort.
EXAMPLE 10A Chinese medicinal composition of the application (ten)
11 parts of dyers woad leaf, 15 parts of honeysuckle, 4 parts of mugwort leaf, 8 parts of cassia twig, 5 parts of earthworm, 13 parts of Chinese angelica and 12 parts of figwort.
EXAMPLE 11 Chinese medicinal composition (eleven) of the application
19 parts of dyers woad leaf, 13 parts of honeysuckle, 8 parts of mugwort leaf, 2 parts of cassia twig, 13 parts of earthworm, 9 parts of Chinese angelica and 10 parts of figwort.
EXAMPLE 12 preparation of the Chinese medicinal composition of the present application
The preparation is prepared and weighed according to the weight ratio in any of the above examples 1-11, and the foot bath is performed after water decoction. The foot bath is carried out for 30 minutes before sleeping every day, the water temperature is adjusted to about 40 ℃, and the foot bath is soaked for about 20 minutes.
Example 13 clinical efficacy experiment
1 case Source
Clinical data are selected from 80 cases of community-acquired pneumonia, non-serious symptoms, and patients with syndrome differentiation of wind-warm lung heat disease and phlegm-heat accumulation in lung syndrome in traditional Chinese medicine clinic and ward collecting and treating in the Shanghai Qinghai Ming's district of medical science in 2022, 1 month-2023.
2 diagnostic criteria
The case selection accords with the traditional Chinese medicine diagnosis standard of community-acquired pneumonia diagnosis and treatment guidelines (2022 edition) community-acquired pneumonia, non-severe western medicine diagnosis standard and community-acquired pneumonia traditional Chinese medicine diagnosis and treatment guidelines (2018 revision), and the traditional Chinese medicine syndrome differentiation belongs to phlegm-heat accumulated lung syndrome; the age range is 20 years to 70 years; patients informed consent, voluntary participation; exclusion criteria: meets the severe pneumonia standard; allergic to quinolones; allergic to qing Jin Bao lung foot bath formula components; combining severe cardiovascular and cerebrovascular diseases, liver diseases, kidney diseases, tumor diseases, hematopoietic diseases, etc.; mental disorder.
3 cases data and groupings
The control group was divided into 40 cases and the treatment group was divided into 40 cases according to the completely random grouping principle. The two groups of patients had no significant differences in sex, age, presence or absence of basal disease, combined administration, and were comparable (P > 0.05) (see table 1).
Table 1 comparison of baseline data for two groups of patients
Note that: the P value of the sex, age, basic disease and combined administration condition before treatment of the two groups is more than 0.05.
Treatment regimen 4
Control group: the treatment of the disease was carried out according to the guidelines for diagnosis and treatment of community-acquired pneumonia (2021 edition) set forth by the respiratory disease institute of the Chinese medical society, using 50ml of levofloxacin sodium chloride injection: 0.25 g/bag (Hunan Koren pharmaceutical Co., ltd., national drug standard H20203719), 50ml intravenous drip, once daily; ambroxol hydrochloride capsule 30mg of capsule (Shanghai Xinyi balance pharmaceutical industry Co., ltd., national drug standard H20000282) is orally taken twice a day, and is subjected to symptomatic and antipyretic treatment when necessary.
Treatment group: based on the conventional Western medicine treatment of the control group (50 ml of levofloxacin sodium chloride injection: 0.25 g/bag (Hunan Colon pharmaceutical Co., ltd., national drug standard H20203719), 50ml of intravenous drip, once daily; +ambroxol hydrochloride capsules 30 mg/box (Shang Xin Yi balance pharmaceutical Co., ltd., national drug standard H20000282) 30mg orally, twice daily) the composition is added to a Qing Jin Bao lung foot bath prescription for treatment: is prepared from 15 g of dyers woad leaf, 15 g of honeysuckle flower, 6 g of mugwort leaf, 6 g of cassia twig, g of earthworm, 9 g of Chinese angelica, 12 g of figwort root by decocting with water, and one dose is taken every day. Decocting in water for 30 min, cooling to 40deg.C, and soaking feet in the decoction to water depth exceeding that of ankle. Soaking for 30 min each time, once every night. The Chinese medicinal decoction pieces are provided by a traditional Chinese medicine pharmacy in a traditional Chinese medicine hospital in Shanghai city still-rest area.
Treatment course: the treatment course of the treatment group and the control group is 7 days.
5 observation index
The Chinese medicine syndromes are integrated: the integral changes of the traditional Chinese medicine symptoms before and after the two groups of treatments are compared. According to the clinical research guidelines of related respiratory diseases in the 'clinical research guidelines of new traditional Chinese medicine', an integral table of clinical symptoms of traditional Chinese medicine is formulated, and the integral table is scored according to the severity of symptoms, and the integral table is scored according to the normal, light, moderate and severe degree. Normally 0 point, slightly 1 point, moderately 2 points and severely 3 points. The patients were evaluated for changes in cough, expectoration, fever, chest pain, shortness of breath, dry mouth, distention in the stomach, or dry stool, and tongue and pulse were recorded descriptive without score.
Inflammation index: the changes in neutrophil%, C-reactive protein (CRP) and Procalcitonin (PCT) levels before and after treatment were compared in both groups.
Adverse reaction: and observing adverse reaction conditions such as rash, nausea, vomiting, dizziness and the like in the two treatment periods.
6 clinical efficacy assessment criteria
Reference to the "guidelines for clinical research of New Chinese medicine" is made to the preparation of related content. The nimodipine method is adopted for calculation, and the formula is as follows: syndrome integral effective rate= (pre-treatment integral post-treatment integral)/pre-treatment integral x 100%;
clinical recovery: the clinical symptoms disappear or basically disappear, and the integral value of the symptoms after treatment is reduced by more than or equal to 95 percent compared with that before treatment;
the effect is shown: the clinical symptoms are obviously improved, and the integral value of the symptoms after treatment is reduced by more than or equal to 70 percent and less than 95 percent compared with that before treatment;
the method is effective: the clinical symptoms are improved, and the integral value of the symptoms is reduced by more than or equal to 30 percent and is less than 70 percent after treatment;
invalidation: the clinical symptoms are not improved, and the symptom integral value is reduced by less than 30% after treatment compared with the integral value before treatment;
total clinical effective rate= (number of recovery cases + number of significant cases + number of effective cases)/total cases x 100%.
7 statistics and analysis
The resulting data was processed using SPSS22.0 statistical software. If the measurement data accords with normal distribution and the variance is uniform, thenThe comparison between groups is shown by the t-test of two independent samples. The paired t-test was used for comparison before and after treatment in the group. If the normal distribution is not met, the inter-group comparison is performed by Mann-Whitney U test of non-parametric test, and the intra-group comparison is performed by Wilcoxon test of non-parametric test, expressed by median (M) and quartile (P25, P75). The count data are described in terms of frequency and percent (n%) using chi-square test. P < 0.05, the difference is considered statistically significant.
8 results
8.1 total integral comparison of symptoms in TCM before and after treatment of two groups of patients
Before treatment, the Chinese medicine syndrome integral of the two groups of patients has no obvious difference (P is more than 0.05), before treatment, the Chinese medicine syndrome integral of the two groups of patients is reduced compared with that before treatment, and the difference has statistical significance (P is less than 0.05). Wherein the improvement condition of the traditional Chinese medicine symptoms of the patients in the treatment group is better than that of the control group, and the difference has statistical significance (p is less than 0.05), as shown in table 2.
TABLE 2 total integral comparison of symptoms in TCM before and after treatment (x.+ -. S) for two groups of patients
Note that: (1)P < 0.05 compared to prior to treatment in the same group; compared with the control group, (2)P < 0.05).
8.2 comparison of clinical efficacy after treatment of two groups of patients
The control group has 40 patients, 29 patients are effective and 11 patients are ineffective after treatment, and the total effective rate is 72.5%; the observed group of 40 patients is treated, and the effective rate is 36, the ineffective rate is 4, and the total effective rate is 90%. The total clinical effective rate of the two groups of patients is compared by chi-square test, and has statistical significance (p is less than 0.05). See table 3.
TABLE 3 comparison of clinical efficacy after treatment for two groups of patients (%)
Note that: the two groups are tested by a chi-square test, and P is less than 0.05.
8.3 comparison of N%, CRP, PCT levels before and after treatment of the two groups
No significant difference (P > 0.05) compared to the pre-treatment N%, CRP, PCT levels for both groups; after treatment, the two groups of N%, CRP and PCT values were all reduced compared with the treatment before treatment, the difference was statistically significant (P < 0.05), wherein the two groups of CRP and PCT value improvement condition treatment groups were superior to the control group, the difference was statistically significant (P < 0.05), the two groups of N% improvement condition treatment groups were equivalent to the control group, and the difference was not statistically significant (P > 0.05), as shown in Table 4.
Table 4 comparison of N%, CRP and PCT levels (x.+ -. S) before and after treatment of both groups
Note that: (1)P < 0.05 compared to prior to treatment in the same group; compared with the control group, (2)P < 0.05).
8.4 adverse effects after two groups of treatments
No obvious adverse reactions were observed before and after the two treatments.
Example 14 animal experiments
1. Experimental materials
1.1 animals
60C 57/BL6J mice, weight (18-22) g, male and female halves, purchased from Shanghai Sipuler-BiKai laboratory animal Co.
1.2 medicaments
The medicine of the first traditional Chinese medicine composition: reference example 1;
the medicine of the traditional Chinese medicine composition II: reference example 2;
drug of control group: 15 parts of dyers woad leaf, 15 parts of honeysuckle, 6 parts of mugwort leaf, 6 parts of ephedra herb, 9 parts of earthworm, 9 parts of prepared rehmannia root and 12 parts of dried rehmannia root, and the mixture is decocted with water for use;
western medicine: levofloxacin sodium chloride injection (Hunan Koren pharmaceutical Co., ltd., national drug substance standard H20203719) and ambroxol hydrochloride capsule (Shanghai Yi balance pharmaceutical Co., ltd., national drug substance standard H20000282).
1.3 major reagents
Staphylococcus aureus (Shanghai collection biotechnology center), tumor Necrosis Factor (TNF) -alpha, interleukin (IL) -6, and the like.
2 method
2.1 animal Molding
The staphylococcus aureus has become one of the main pathogens of iatrogenic pneumonia and community pneumonia at present, so the pathogen is selected for modeling. After the mice were adaptively fed for one week, 50 mice were randomly selected and divided into 4 groups of 10 mice each, respectively, the first group of the present application, the second group of the present application, the control group and the model group, the mice were anesthetized with diethyl ether, and 30. Mu.l of the mixture containing 2X 10 9 Colony Forming Unit (CFU) staphylococcus aureus suspension drops were used to nasal infect mice, with the remaining 10 mice as a blank, injected with an equal volume of PBS.
2.2 Experimental protocol
After 24 hours from the molding, the hair around the limbs of the mice was removed, and the molded five groups of mice were treated with conventional western medicines daily, and were intraperitoneally injected with 10 mg/(kg·d) +60 mg/(kg·d) of the sodium chloride injection of levofloxacin and the ambroxol hydrochloride capsule was intragastrically administered in the following manner:
the first group of the application: the medicine in the first group of the application is boiled for 30 minutes by slow fire, the towel is divided into four small blocks, the four small blocks are soaked in the medicine liquid, and the towel is taken out and applied to the dehairing place of the mice for 20 minutes when the water temperature is reduced to 38-40 ℃.
The application is two: the medicine of the second group of the application is boiled for 30 minutes by slow fire, the towel is divided into four small blocks, the four small blocks are soaked in the medicine liquid, and the towel is taken out and applied to the dehairing place of the mice for 20 minutes when the water temperature is reduced to 38-40 ℃.
Control group: boiling the medicine of the control group with slow fire for 30 minutes, dividing the towel into four small blocks, soaking in the medicine liquid, and taking out the towel and applying the towel to the dehairing place of the mice when the water temperature is reduced to 38-40 ℃ for 20 minutes.
Blank and model mice were applied to the hair removal site with a towel of distilled water at about 40 ℃ which was soaked.
The treatments were all treated for 1 week.
2.3 detection index
After the administration is finished on day 2, the surviving mice are anesthetized, the lung lobe tissues are taken out, the abdominal aorta is taken out for blood taking, and the supernatant obtained by centrifugation is placed in a refrigerator at-80 ℃ for freezing for cytokine detection. TNF-alpha and IL-6 levels in mouse serum were determined according to the ELISA kit-attached instructions, respectively.
3 statistical method
SPSS was used to statistically process the data. Metering data useThe method is characterized in that t-test is adopted by a normal distributor, and non-parametric rank sum test is adopted by a non-normal distributor; the counting data is represented by examples or percentages, the non-grade data is checked by chi-square, and the grade data is checked by rank sum. With P<A difference of 0.05 is statistically significant.
Results 4 results
The results of the TNF-alpha and IL-6 levels in the serum of mice are shown in Table 1, which shows that each group of mice in the model group died most during the course of the experiment. After dosing intervention, it was found that the levels of TNF- α and IL-6 were increased (P < 0.05) in the model group compared to the blank group; indicating that the immune response resulted in increased inflammatory factor release following a staphylococcus aureus infection. After the drug treatment, compared with the model group, the levels of TNF-alpha and IL-6 in the control group, the first group and the second group are obviously down-regulated, and all have obvious differences (P is less than 0.01). Compared with the control group, the down-regulation of TNF-alpha and IL-6 levels of the first group and the second group is more remarkable, and the statistical difference (P < 0.05) exists. The first and second groups of the application have the effect of down-regulating the levels of TNF-alpha and IL-6 inflammatory factors of mice after the staphylococcus aureus infection, and the down-regulating trend of the group of the application is most obvious (P is less than 0.05).
TABLE 1 TNF-. Alpha.and IL-6 expression levels (x.+ -. S, mmol/L) after administration in groups of mice
Note that: compared with the blank group, #P < 0.05; compared with the model group, delta P is less than 0.01; compared with the control group, O P is less than 0.05; p < 0.05 compared to the second group of the application.
The foregoing is merely a preferred embodiment of the present application, and it should be noted that modifications and additions may be made to those skilled in the art without departing from the method of the present application, which modifications and additions are also to be considered as within the scope of the present application.
Claims (8)
1. The traditional Chinese medicine composition for treating community-acquired pneumonia is characterized by being prepared from the following raw materials in parts by weight: 11-19 parts of dyers woad leaf, 11-19 parts of honeysuckle, 2-10 parts of mugwort leaf, 2-10 parts of cassia twig, 5-13 parts of earthworm, 5-13 parts of Chinese angelica and 8-16 parts of radix scrophulariae.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 13-17 parts of dyers woad leaf, 13-17 parts of honeysuckle, 4-8 parts of mugwort leaf, 4-8 parts of cassia twig, 7-11 parts of earthworm, 7-11 parts of Chinese angelica and 10-14 parts of radix scrophulariae.
3. The traditional Chinese medicine composition according to claim 2, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 parts of dyers woad leaf, 15 parts of honeysuckle, 6 parts of mugwort leaf, 6 parts of cassia twig, 9 parts of earthworm, 9 parts of Chinese angelica and 12 parts of figwort.
4. The traditional Chinese medicine composition according to any one of claims 1-3, wherein the traditional Chinese medicine composition is a foot bath traditional Chinese medicine composition.
5. The traditional Chinese medicine composition according to claim 4, wherein the foot bath composition is used in the following method: weighing the raw materials according to the weight proportion of any one of claims 1-3, decocting with water, performing foot bath, adjusting the water temperature to about 40 ℃ before sleeping for 30 minutes every day, and soaking for 20 minutes.
6. The pharmaceutical composition for treating community-acquired pneumonia is characterized by comprising western medicines and a traditional Chinese medicine composition according to any one of claims 1-5, wherein the western medicines are levofloxacin sodium chloride injection and ambroxol hydrochloride capsules.
7. Use of the traditional Chinese medicine composition according to any one of claims 1-5 or the pharmaceutical composition according to claim 4 in the preparation of a medicament for treating community-acquired pneumonia.
8. The use according to claim 7, wherein the community-acquired pneumonia is a phlegm-heat accumulating lung syndrome.
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