CN116942076B - Automatic measurement system for measuring full-field wavefront aberration of human eyes - Google Patents

Automatic measurement system for measuring full-field wavefront aberration of human eyes Download PDF

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CN116942076B
CN116942076B CN202310915359.0A CN202310915359A CN116942076B CN 116942076 B CN116942076 B CN 116942076B CN 202310915359 A CN202310915359 A CN 202310915359A CN 116942076 B CN116942076 B CN 116942076B
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electric
module
light
scanning
light source
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CN116942076A (en
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刘永基
张馨月
王雁
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Nankai University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/103Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining refraction, e.g. refractometers, skiascopes

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Abstract

The invention provides an automated measurement system for measuring wavefront aberrations of a full field of view of a human eye, the system comprising: the device comprises a light source module, a fixation and monitoring module, a scanning module and a measuring module; the light source module is used for generating infrared stable parallel light beams; the fixation and monitoring module is used for fixing the fixation position of human eyes and monitoring the fixation condition of the human eyes; the scanning module is used for changing the direction of the light beam, realizing two-dimensional scanning, enabling the parallel light to enter human eyes at different angles of view, and forming point light sources at different positions of retina; the measuring module is used for measuring light rays emitted by a point light source on retina and emitted by human eyes to obtain wave front aberration. The invention has the characteristics of high scanning speed, high precision, wide measuring field of view and simple principle.

Description

Automatic measurement system for measuring full-field wavefront aberration of human eyes
Technical Field
The invention belongs to the technical field of ocular optics and optical imaging measurement, and particularly relates to an automatic measurement system for measuring the wavefront aberration of the full field of view of a human eye.
Background
People's attention to peripheral vision has been continued for over 50 years, and peripheral vision plays an important role in people's daily life, such as reading, driving, etc. In fact, the peripheral region occupies a greater proportion of the field of view than the on-axis region. And studies have shown that refraction of the peripheral vision has an important correlation with myopia progression. Experiments on human and animal eyes show that the far vision of the peripheral vision has a high possibility of causing myopia, so that the research on the peripheral vision has great significance for myopia prevention and control. In addition, peripheral vision is also important for patients suffering from central visual field loss (CFL). CFL patients cannot perceive the environment with their fovea, they are highly dependent on peripheral vision. Thus, the quality of images over their peripheral field of view can significantly affect their lives.
The two points are combined, and the method has great significance in researching and accurately measuring the aberration of the peripheral visual field.
Currently, a widely used method of peripheral field-of-view aberration measurement is to use an autorefractor and a wavefront aberration measurement technique based on a shack-Hartmann wavefront sensor. An autorefractor can measure ametropia, but can only measure spherocylindrical power, and cannot obtain higher order aberration information.
In recent years, the measurement technology of the base Yu Shake-Hartmann wavefront sensor is rapidly developed, and a number of defects still remain to be solved. Researchers have employed various methods and techniques to make wavefront aberration measurements of a larger field of view. The current large field aberration measurement system mainly comprises the following two modes: scanning systems and non-scanning systems are employed. The scanning modes of the scanning system are mainly two types, and a relay telescope and a scanning galvanometer are combined to finish scanning; the whole light path is rotated mechanically to complete scanning. The non-scanning system mainly adopts a mode of rotating the head or eyes of the subject, and sequentially obtains the aberration of different fields of view. The mode of combining the relay telescope and the scanning galvanometer is adopted, and because the effect of the performance of the relay telescope is influenced, a larger field of view is generally difficult to measure, the maximum field of view of the current full-field wavefront aberration measurement is +/-15 degrees, and the clinical measurement requirement can not be met far; the measuring method of mechanically rotating the whole light path can realize the scanning range of +/-40 degrees of the horizontal view field, but the wave front aberration of the large view field in other directions cannot be measured due to the limitation of a mechanical structure. The non-scanning peripheral visual field aberration measurement adopts a mode of rotating the head or eyes of a subject, so that the requirement on the coordination degree of the subject is high in order to obtain an accurate measurement result, and more importantly, the measurement time is long, and the measurement of the one-dimensional visual field is completed, so that the measurement at least needs 10-20 minutes, and the clinical application of the measurement is limited.
In summary, in order to quickly, accurately and objectively obtain the peripheral field aberration data of the large field of view of the human eye, a scanning mode should be adopted. However, the current wavefront aberration measuring system adopting the scanning mode has the problems that the measuring field of view is small, or only the wavefront data of one-dimensional field of view can be measured, and the application requirement cannot be met.
Disclosure of Invention
The invention aims to provide an automatic measuring system for measuring the full visual field wave front aberration of human eyes, which uses a reflective structure and relies on an electric platform to realize the full visual field, large angle, quick and objective measurement of the visual field aberration of the periphery of human eyes.
The technical scheme of the invention is as follows:
An automated measurement system for measuring full field wavefront aberrations of a human eye, the system comprising: the device comprises a light source module, a fixation and monitoring module, a scanning module and a measuring module;
the light source module is used for generating infrared parallel light beams with good quality;
The fixation and monitoring module is used for fixing the fixation position of human eyes and monitoring the fixation condition of the human eyes;
The scanning module is used for changing the direction of the infrared parallel light beam to realize two-dimensional scanning, so that the infrared parallel light beam enters the human eye at different angles of view, and point light sources are formed at different positions of retina;
The measuring module is used for measuring light rays emitted by a point light source on retina and emitted by human eyes to obtain wave front aberration.
Further, the light source module comprises an infrared light source, a spatial filter and a diaphragm, and the infrared light source, the spatial filter and the diaphragm are sequentially arranged along an emergent light path; the diaphragm transmits the infrared parallel light beam to the scanning module through a first beam splitter;
the infrared light source is used for generating an infrared light beam;
the spatial filter is used for reducing factory noise of the light source and filtering stray light;
the diaphragm is used for guaranteeing that the light spot entering the scanning module is a uniform circular light spot.
Further, the scanning module comprises an electric beam lifter, an electric horizontal displacement table, an electric lifting displacement table, an electric rotary table, a reflecting mirror and a guide rail sliding block;
The electric beam lifter comprises two reflectors which are placed at 45 degrees, so that the infrared beam is ensured to be horizontal and passes through the rotation center of the reflectors; the electric beam lifter and the reflecting mirror are sequentially arranged on the transmission line of the infrared parallel beam;
the reflecting mirror is arranged on the electric rotating table and the electric lifting displacement table top through the supporting rod, and is arranged on the electric horizontal displacement table top through the guide rail sliding block;
The infrared light beam is reflected to the reflector through the electric beam lifter, and the infrared light beam always passes through the center of the entrance pupil of human eyes by controlling the electric horizontal displacement table, the electric lifting displacement table and the electric rotating table.
Further, the measuring module comprises a shack-Hartmann sensor, a first lens of a relay telescope and a second lens of the relay telescope;
The CCD image plane of the Sack-Hartmann sensor is conjugate with the entrance pupil plane of human eyes through the first lens of the relay telescope and the second lens of the relay telescope.
Further, the fixation and monitoring module comprises a sighting target and a pupil camera, and the pupil camera is connected with the measuring module through a second beam splitter;
The human eyes watch the visible optotype through the reflecting mirror;
The pupil camera is used for monitoring human eyes and monitoring the approximate trend of light rays, so that the light rays can pass through the center of the entrance pupil of the human eyes in the experimental process.
Further, the system also comprises a driver, wherein the electric beam lifter, the electric horizontal displacement table, the electric lifting displacement table and the electric rotating table are all connected with the driver; the driver is used for controlling the electric beam lifter, the electric horizontal displacement table, the electric lifting displacement table and the electric rotating table to act so as to complete full-view field scanning;
The full-view field scanning is to perform two-dimensional scanning on the human eyes along a plurality of meridians by light rays, and the view field range is +/-45 degrees for any one meridian of the plurality of meridians.
Further, the reflecting mirror is a large-caliber hot mirror.
Further, motors of the electric beam lifter, the electric horizontal displacement table, the electric lifting displacement table and the electric rotary table are servo motors.
The invention has the technical effects that:
The automatic measuring system for measuring the wavefront aberration of the full field of view of the human eye has the characteristics of high scanning speed (using a servo motor), high precision (no extra system aberration is introduced into a reflection system), wide measuring field of view (the measuring field of view can reach +/-45 degrees in the full field of view), and simple principle (a large-caliber reflector translates and rotates).
Drawings
The accompanying drawings illustrate various embodiments by way of example in general and not by way of limitation, and together with the description and claims serve to explain the inventive embodiments. Wherever possible, the same reference numbers will be used throughout the drawings to refer to the same or like parts. Such embodiments are illustrative and not intended to be exhaustive or exclusive of the present apparatus or method.
FIG. 1 shows a schematic system diagram of the present invention;
FIG. 2 shows a full field scan trajectory schematic at the retina of the present invention;
FIG. 3 is a schematic diagram of the rotation angle and translation distance according to an embodiment of the present invention;
Reference numerals illustrate: 1. pupil cameras; 2. an infrared light source; 3. a spatial filter; 4. a diaphragm; 5. shack-Hartmann wavefront sensor; 6. a relay telescope first lens; 7. a second beam splitter; 8. a relay telescope second lens; 9. a first beam splitter; 10. an electric beam lifter; 11. a reflecting mirror; 12. an electric lifting displacement table; 13. an electric horizontal displacement table; 14. an electric rotating table; 15. a visual target; 16. a human eye; 17. a human eye entrance pupil; 18. a retina; 19. and a guide rail sliding block.
Detailed Description
It should be noted that, without conflict, the embodiments of the present application and features of the embodiments may be combined with each other. The application will be described in detail below with reference to the drawings in connection with embodiments.
An embodiment of the present invention provides an automated measurement system for measuring wavefront aberration of a full field of view of a human eye, as shown in fig. 1, the system comprising: the device comprises a light source module, a fixation and monitoring module, a scanning module and a measuring module;
In the measuring process, the fixation and monitoring module ensures that the human eyes need to watch the sighting target 15 all the time, the infrared parallel light beams emitted by the light source module enter the human eyes 16 after passing through the scanning module, and point light sources are formed at different positions of retina; light emitted by the point light source is emitted from the eye, and after passing through the measuring module, the field wavefront aberration information is obtained by the shack-Hartmann wavefront sensor.
The light source module is used for generating infrared stable parallel light beams; the fixation and monitoring module is used for fixing the fixation position of human eyes and monitoring the fixation condition of the human eyes; the scanning module is used for changing the direction of the light beam, realizing two-dimensional scanning, enabling the parallel light to enter human eyes at different angles of view, and forming point light sources at different positions of retina; the measuring module is used for measuring light rays emitted by the point light source on the retina and emitted by the human eye to obtain wave front aberration.
It should be noted that, assuming the retina 18 is a circular disk, fig. 2 provides a full field scan trajectory at the retina. The scanning module enables the parallel light to enter human eyes at different angles of view, and scans different sites on the horizontal meridian first. The electric lifting table is matched with the beam lifter to enable the beam to reach other meridians, so that the scanning of the whole view field is completed.
In one embodiment, the light source module comprises an infrared light source 2, a spatial filter 3 and a diaphragm 4, and the diaphragm 4 is connected with the scanning module through a first beam splitter 9;
The infrared light source 2 is used for generating an infrared light beam;
The spatial filter 3 is used for reducing the factory noise of the light source and filtering stray light;
The diaphragm 4 is used for ensuring that the light spot entering the scanning module is a uniform circular light spot.
In one embodiment, the scanning module comprises an electric beam lifter 10, an electric horizontal displacement table 13, an electric lifting displacement table 12, an electric rotating table 14, a reflecting mirror 11 and a guide rail sliding block 19;
the electric beam lifter 10 comprises two 45-degree placed reflecting mirrors, ensures the infrared beam to be horizontal and passes through the rotation center of the reflecting mirror 11;
the reflecting mirror 11 is arranged on the electric rotating table 14 and the electric lifting displacement table 12 through a supporting rod, and is arranged on the electric horizontal displacement table 13 through the guide rail sliding block 19;
the infrared light beam is reflected to the reflecting mirror 11 through the electric beam lifter 10, and the infrared light beam always passes through the center of the entrance pupil 17 of the human eye 16 by controlling the electric horizontal displacement table 13, the electric lifting displacement table 12 and the electric rotating table 14.
In one embodiment, the measurement module comprises a shack-Hartmann sensor 5, a relay telescope first lens 6, a relay telescope second lens 8;
The CCD image plane of the shack-hartmann sensor 5 is conjugate to the entrance pupil 17 plane of the human eye 16 by the relay telescope first lens 6 and the relay telescope second lens 8.
In one embodiment, the fixation and monitoring module comprises a sighting target 15 and a pupil camera 1, and the pupil camera 1 is connected with the measuring module through a second beam splitter 7;
the human eye 11 looks at the visible optotype through said mirror 11;
the pupil camera 1 is used for monitoring the human eye 16 and monitoring the general trend of light, ensuring that the light passes through the center of the entrance pupil 17 of the human eye during the experimental process.
In one embodiment, the system further comprises a driver, and the control of the electric beam lifter 10, the electric horizontal displacement table 13, the electric lifting displacement table 12 and the electric rotating table 14 can be finished by programming the driver, so that the full-field scanning of the human eye is finished;
the full-view field scanning is to perform two-dimensional scanning on the human eye 16 along a plurality of meridians by using light rays, and the view field range is +/-45 degrees for any one meridian of the plurality of meridians.
The reflecting mirror 11 is a large-caliber hot mirror.
The motors of the electric beam lifter 10, the electric horizontal displacement table 13, the electric lifting displacement table 12 and the electric rotary table 14 are servo motors.
Illustratively, referring to the horizontal field of view of FIG. 3, by translating the distance of mirror l, rotating the angle of mirror α, light rays can reach the human eye in different fields of view. Through certain geometrical optics and mathematical deduction, the relation among the parameters can be obtained. The parameter relation is controlled by programming to complete the driving of the servo motor, so as to control a plurality of electric platforms in the scanning system.
The foregoing is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art, who is within the scope of the present invention, should make equivalent substitutions or modifications according to the technical solution of the present invention and the inventive concept thereof, and should be covered by the scope of the present invention.

Claims (6)

1. An automated measurement system for measuring wavefront aberrations of a full field of view of a human eye, the system comprising: the device comprises a light source module, a fixation and monitoring module, a scanning module and a measuring module;
the light source module is used for generating infrared parallel light beams;
The fixation and monitoring module is used for fixing the fixation position of human eyes and monitoring the fixation condition of the human eyes;
the scanning module is used for changing the direction of the infrared parallel light beam, carrying out two-dimensional scanning, enabling the infrared parallel light beam to enter the human eye at different angles of view, and forming point light sources at different positions of retina;
The measuring module is used for measuring reflected light rays emitted by the point light sources to obtain wavefront aberration;
the scanning module includes: an electric beam lifter (10), an electric horizontal displacement table (13), an electric lifting displacement table (12), an electric rotary table (14), a reflecting mirror (11) and a guide rail sliding block (19);
The electric beam lifter (10) comprises two reflectors placed at 45 degrees, so that infrared beams are ensured to be horizontal and pass through the rotation center of the reflector (11); the electric beam lifter (10) and the reflecting mirror (11) are sequentially arranged on the transmission path of the infrared parallel beam; the reflecting mirror (11) is arranged on the table top of the electric rotating table (14) and the electric lifting displacement table (12) through a supporting rod, and is arranged on the table top of the electric horizontal displacement table (13) through the guide rail sliding block (19);
The infrared parallel light beam is reflected to the reflecting mirror (11) through the electric light beam lifter (10), and the infrared light beam always passes through the center of an entrance pupil (17) of a human eye (16) through controlling the electric horizontal displacement table (13), the electric lifting displacement table (12) and the electric rotating table (14);
The system further includes a driver; the electric beam lifter (10), the electric horizontal displacement table (13), the electric lifting displacement table (12) and the electric rotating table (14) are all connected with the driver; the driver is used for controlling the electric beam lifter (10), the electric horizontal displacement table (13), the electric lifting displacement table (12) and the electric rotating table (14) to act so as to complete full-view field scanning;
the full-view field scanning is to perform two-dimensional scanning on the human eyes (16) by light along a plurality of meridians, and the view field range is +/-45 degrees for any one meridian of the plurality of meridians.
2. The system of claim 1, wherein the light source module comprises: an infrared light source (2), a spatial filter (3) and a diaphragm (4); the infrared light source (2), the spatial filter (3) and the diaphragm (4) are sequentially arranged along an emergent light path; the diaphragm (4) transmits the infrared parallel light beam to the scanning module through a first beam splitter (9);
The infrared light source (2) is used for generating an infrared light beam;
The spatial filter (3) is used for reducing factory noise of the light source and filtering stray light;
the diaphragm (4) is used for ensuring that the light spots entering the scanning module are uniform circular light spots.
3. The system according to claim 1, characterized in that the measurement module comprises a shack-hartmann sensor (5), a relay telescope first lens (6), a relay telescope second lens (8);
The shack-Hartmann sensor (5), the first relay telescope lens (6) and the second relay telescope lens (8) are arranged on a reflected light path emitted by the point light source;
The CCD image surface of the shack-Hartmann sensor (5) is conjugated with the entrance pupil (17) surface of the human eye (16) through the first lens (6) of the relay telescope and the second lens (8) of the relay telescope.
4. The system according to claim 1, characterized in that the fixation and monitoring module comprises a optotype (15) and a pupil camera (1); the pupil camera (1) transmits reflected light rays emitted by the point light sources to the measuring module through a second beam splitter (7);
the human eye (16) looks at the visible optotype through the reflecting mirror (11);
The pupil camera (1) is used for monitoring human eyes (16) and monitoring the trend of light rays, so that the light rays pass through the center of an entrance pupil (17) of the human eyes in the experimental process.
5. The system according to claim 4, characterized in that the mirror (11) is a large caliber hot mirror.
6. The system according to claim 1, wherein the motors of the electric beam lifter (10), the electric horizontal displacement table (13), the electric lifting displacement table (12) and the electric rotary table (14) are servo motors.
CN202310915359.0A 2023-07-24 2023-07-24 Automatic measurement system for measuring full-field wavefront aberration of human eyes Active CN116942076B (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021046973A1 (en) * 2019-09-09 2021-03-18 中国科学院苏州生物医学工程技术研究所 Common beam scanning retina imaging system
CN115590460A (en) * 2022-05-23 2023-01-13 上海健康医学院(Cn) Wavefront aberration detection system for eyes
CN115956875A (en) * 2022-11-23 2023-04-14 杭州微晓医疗科技有限公司 System and method for optical inspection of eye

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060126018A1 (en) * 2004-12-10 2006-06-15 Junzhong Liang Methods and apparatus for wavefront sensing of human eyes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021046973A1 (en) * 2019-09-09 2021-03-18 中国科学院苏州生物医学工程技术研究所 Common beam scanning retina imaging system
CN115590460A (en) * 2022-05-23 2023-01-13 上海健康医学院(Cn) Wavefront aberration detection system for eyes
CN115956875A (en) * 2022-11-23 2023-04-14 杭州微晓医疗科技有限公司 System and method for optical inspection of eye

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