CN116940325A - Composition for conditioning keratin materials - Google Patents
Composition for conditioning keratin materials Download PDFInfo
- Publication number
- CN116940325A CN116940325A CN202180094695.2A CN202180094695A CN116940325A CN 116940325 A CN116940325 A CN 116940325A CN 202180094695 A CN202180094695 A CN 202180094695A CN 116940325 A CN116940325 A CN 116940325A
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- acid
- component
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- composition according
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- 239000000203 mixture Substances 0.000 title claims abstract description 133
- 230000003750 conditioning effect Effects 0.000 title claims abstract description 11
- 102000011782 Keratins Human genes 0.000 title description 6
- 108010076876 Keratins Proteins 0.000 title description 6
- 239000000463 material Substances 0.000 title description 6
- -1 fatty acid esters Chemical class 0.000 claims abstract description 65
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 39
- 239000000194 fatty acid Substances 0.000 claims abstract description 39
- 229930195729 fatty acid Natural products 0.000 claims abstract description 39
- 239000002253 acid Substances 0.000 claims abstract description 35
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 29
- 229920000223 polyglycerol Polymers 0.000 claims abstract description 24
- 239000004094 surface-active agent Substances 0.000 claims abstract description 23
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims abstract description 18
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 18
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229940061720 alpha hydroxy acid Drugs 0.000 claims abstract description 12
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims abstract description 12
- 150000007513 acids Chemical class 0.000 claims abstract description 10
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000000174 gluconic acid Substances 0.000 claims abstract description 9
- 235000012208 gluconic acid Nutrition 0.000 claims abstract description 9
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000002243 precursor Substances 0.000 claims abstract description 8
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 8
- UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229950006191 gluconic acid Drugs 0.000 claims abstract description 6
- 229940099563 lactobionic acid Drugs 0.000 claims abstract description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 32
- 125000000217 alkyl group Chemical group 0.000 claims description 23
- 150000004665 fatty acids Chemical class 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 19
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 18
- 239000003945 anionic surfactant Substances 0.000 claims description 17
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 16
- 229920001282 polysaccharide Polymers 0.000 claims description 15
- 239000005017 polysaccharide Substances 0.000 claims description 15
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 13
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 12
- 239000002738 chelating agent Substances 0.000 claims description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 150000002170 ethers Chemical class 0.000 claims description 12
- 239000008103 glucose Substances 0.000 claims description 12
- 150000002148 esters Chemical class 0.000 claims description 11
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims description 10
- 239000002537 cosmetic Substances 0.000 claims description 9
- IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical class O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 claims description 8
- 239000002280 amphoteric surfactant Substances 0.000 claims description 8
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 8
- 239000004310 lactic acid Substances 0.000 claims description 8
- 235000014655 lactic acid Nutrition 0.000 claims description 8
- 235000000346 sugar Nutrition 0.000 claims description 8
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 7
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 7
- 229940071160 cocoate Drugs 0.000 claims description 7
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 7
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims description 6
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 6
- 235000002949 phytic acid Nutrition 0.000 claims description 6
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 5
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims description 5
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 5
- 125000003368 amide group Chemical group 0.000 claims description 5
- 125000005456 glyceride group Chemical group 0.000 claims description 5
- 229910052700 potassium Inorganic materials 0.000 claims description 5
- 239000000230 xanthan gum Substances 0.000 claims description 5
- VKZRWSNIWNFCIQ-WDSKDSINSA-N (2s)-2-[2-[[(1s)-1,2-dicarboxyethyl]amino]ethylamino]butanedioic acid Chemical compound OC(=O)C[C@@H](C(O)=O)NCCN[C@H](C(O)=O)CC(O)=O VKZRWSNIWNFCIQ-WDSKDSINSA-N 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 4
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims description 4
- 229920002148 Gellan gum Polymers 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 235000010980 cellulose Nutrition 0.000 claims description 4
- 235000015165 citric acid Nutrition 0.000 claims description 4
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 4
- 229930182830 galactose Natural products 0.000 claims description 4
- 235000010492 gellan gum Nutrition 0.000 claims description 4
- 239000000216 gellan gum Substances 0.000 claims description 4
- 230000007794 irritation Effects 0.000 claims description 4
- 239000011591 potassium Substances 0.000 claims description 4
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims description 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 3
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims description 3
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 claims description 3
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 claims description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 3
- 150000007942 carboxylates Chemical class 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 229930195712 glutamate Natural products 0.000 claims description 3
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 claims description 3
- 239000001630 malic acid Substances 0.000 claims description 3
- 235000011090 malic acid Nutrition 0.000 claims description 3
- 150000002762 monocarboxylic acid derivatives Chemical class 0.000 claims description 3
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 claims description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
- 239000010452 phosphate Substances 0.000 claims description 3
- 229940068041 phytic acid Drugs 0.000 claims description 3
- 239000000467 phytic acid Substances 0.000 claims description 3
- 229940083982 sodium phytate Drugs 0.000 claims description 3
- UZVUJVFQFNHRSY-OUTKXMMCSA-J tetrasodium;(2s)-2-[bis(carboxylatomethyl)amino]pentanedioate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CC[C@@H](C([O-])=O)N(CC([O-])=O)CC([O-])=O UZVUJVFQFNHRSY-OUTKXMMCSA-J 0.000 claims description 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 2
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 2
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- 229920000136 polysorbate Chemical class 0.000 claims description 2
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- 229940068977 polysorbate 20 Drugs 0.000 claims description 2
- 229960003975 potassium Drugs 0.000 claims description 2
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 claims description 2
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- 239000001509 sodium citrate Substances 0.000 claims description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
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- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
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- 229940080421 coco glucoside Drugs 0.000 claims 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-M decanoate Chemical compound CCCCCCCCCC([O-])=O GHVNFZFCNZKVNT-UHFFFAOYSA-M 0.000 claims 1
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- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 229940001447 lactate Drugs 0.000 claims 1
- LKUNXBRZDFMZOK-UHFFFAOYSA-N rac-1-monodecanoylglycerol Chemical compound CCCCCCCCCC(=O)OCC(O)CO LKUNXBRZDFMZOK-UHFFFAOYSA-N 0.000 claims 1
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- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229960003330 pentetic acid Drugs 0.000 description 1
- 150000002972 pentoses Chemical class 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 150000003009 phosphonic acids Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229960003764 polydatin Drugs 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 235000012015 potatoes Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
- 238000013077 scoring method Methods 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 230000036555 skin type Effects 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229940007636 sodium lauroyl methyl isethionate Drugs 0.000 description 1
- NVIZQHFCDBQNPH-UHFFFAOYSA-M sodium;2-dodecanoyloxypropane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCC(=O)OC(C)CS([O-])(=O)=O NVIZQHFCDBQNPH-UHFFFAOYSA-M 0.000 description 1
- HSFQBFMEWSTNOW-UHFFFAOYSA-N sodium;carbanide Chemical group [CH3-].[Na+] HSFQBFMEWSTNOW-UHFFFAOYSA-N 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 229940032085 sucrose monolaurate Drugs 0.000 description 1
- 150000003445 sucroses Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 150000003464 sulfur compounds Chemical class 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- HSTZMXCBWJGKHG-CUYWLFDKSA-N trans-piceid Polymers O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(\C=C\C=2C=CC(O)=CC=2)=C1 HSTZMXCBWJGKHG-CUYWLFDKSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
Provided herein are compositions for conditioning skin comprising the following components: a) At least one hydroxy-containing acid selected from the group consisting of alpha-hydroxy acids, preferably lower acids having 2 to 12 carbon atoms, preferably 2 to 8 carbon atoms, or 2 to 6 carbon atoms, gluconic acid, lactobionic acid and salicylic acid, or precursors thereof; b) At least one nonionic surfactant selected from fatty acid esters of polyglycerols or fatty acid ethers of polyglycerols; and C) at least one additional surfactant other than component B).
Description
Technical Field
The present application relates to compositions for conditioning the skin, in particular the stratum corneum. The application also relates to methods of conditioning skin, particularly the stratum corneum, using the compositions of the application.
Background
Skin is widely present on the surface of the human body. Many people have long sought to freshen their body surfaces for comfort in daily life and work. Delivery of products with skin benefits (e.g., hydration, moisturization, anti-aging, whitening, cleansing, smoothness, etc.) has been an ultimate goal in the cosmetic field.
Keratin materials (e.g., skin) are known to suffer from aging due to various factors; thus, an anti-aging effect can be achieved through various approaches. For example, the Stratum Corneum (SC) is the outermost layer of the epidermis. Promoting replacement of the SC (turn over) may make the skin smoother and brighter, and fine lines or wrinkles on the skin will be less pronounced.
Alpha Hydroxy Acids (AHAs) are representative exfoliating elements. The acid may play a role in unlocking SC desmosomes, a critical part of cell attachment. In particular, the acid helps to remove the connective structure between the keratins in the stratum corneum and shows a gentle fusion effect of the keratins. However, it is also known that AHA (e.g., glycolic acid) may still be irritating to the skin.
Thus, there remains a need in the art to develop new compositions for conditioning the skin, in particular for anti-aging purposes by promoting SC replacement.
Summary of The Invention
Through intensive research, the inventors have surprisingly found that AHA-induced SC shedding and replacement can be promoted by using a specific combination of at least two surfactants, in particular at least one fatty acid ester of polyglycerol or fatty acid ether of polyglycerol.
Thus, one subject of the present application is thus a leave-on composition for conditioning the skin comprising:
at least one hydroxy-containing acid, such as alpha-hydroxy acid, gluconic acid, lactobionic acid and salicylic acid, or precursors thereof;
at least one nonionic surfactant selected from fatty acid esters of polyglycerol; and
at least one other surfactant.
The composition according to the application is particularly useful for conditioning the skin, in particular the stratum corneum. Thus, the compositions of the present application may be in various forms, particularly solutions, such as lotions, sprays, and the like, to be applied to the scalp, directly to the skin.
Description of the application
Throughout the specification, including the claims, unless the claims otherwise refer to, the term "comprising" is to be understood as synonymous with "comprising at least one". Furthermore, the expression "at least one" as used in the present specification is equivalent to the expression "one or more".
Throughout the specification, including the claims, embodiments defined by "comprising" and the like are to be understood as encompassing both the preferred embodiments defined by "consisting essentially of … …" and the preferred embodiments defined by "consisting of … …".
Except in the operating examples, or where otherwise indicated, all numbers expressing amounts of ingredients and/or reaction conditions are to be understood as being modified in all instances by the term "about," having a meaning commonly known in the art, e.g., within 10% of the indicated number (e.g., "about 10%" means 9% -11%, and about "2%" means 1.8% -2.2%).
In the present application, unless explicitly mentioned otherwise, the content, parts and percentages are expressed on a weight basis.
The present application relates to an aqueous composition for conditioning skin comprising the following components:
a) At least one hydroxy-containing acid, such as alpha-hydroxy acid, gluconic acid, lactobionic acid and salicylic acid, or precursors thereof;
b) At least one nonionic surfactant selected from fatty acid esters of polyglycerols or fatty acid ethers of polyglycerols; and
c) At least one additional surfactant other than component B).
The application thus provides the use of a combination of at least one fatty acid ester of polyglycerol or fatty acid ether of polyglycerol of component B) and another surfactant of component C) for enhancing the performance of hydroxyl-containing acids while avoiding or reducing skin irritation, in particular irritation caused by acids and/or by conventional surfactants.
Other features and advantages of the present application will become more apparent upon reading the following specification and examples.
Component A), hydroxy acid
The composition according to the application comprises at least one hydroxy-acid as component A).
According to the application, the hydroxyl-containing acid may in particular be an alpha-hydroxy acid. According to the application, the term "alpha-hydroxy acid" is understood to mean a carboxylic acid having at least one hydroxy function occupying the alpha-position (carbon adjacent to the carboxylic acid function) on said acid. The acid is preferably present in the final composition in the form of the free acid.
The alpha-hydroxy acids include, for example, citric acid, lactic acid, methyl lactic acid, glucuronic acid, glycolic acid, pyruvic acid, 2-hydroxybutyric acid, 2-hydroxyvaleric acid, 2-hydroxycaproic acid, 2-hydroxyheptanoic acid, 2-hydroxyoctanoic acid, 2-hydroxynonanoic acid, 2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, 2-hydroxydodecanoic acid, 2-hydroxytetradecanoic acid, 2-hydroxyhexadecanoic acid, 2-hydroxyoctadecanoic acid, 2-hydroxytetracosanoic acid, 2-hydroxyeicosanoic acid, mandelic acid, phenyllactic acid, gluconic acid, galacturonic acid, laconic acid, ribonic acid, hydroxymalonic acid, tartaric acid, malic acid, fumaric acid, and mixtures thereof. Mixtures of these various acids may also be used.
According to an embodiment of the application, the alpha-hydroxy acid is preferably a lower acid having 2 to 12 carbon atoms, preferably 2 to 8 carbon atoms, or 2 to 6 carbon atoms.
According to an embodiment of the application, the alpha-hydroxy acid is preferably a monocarboxylic acid.
Examples of hydroxyl-containing acids may include glycolic acid, lactic acid, malic acid, citric acid, gluconic acid, lactobionic acid, tartaric acid, and salicylic acid.
According to a particular embodiment of the application, hydroxy acid-containing precursors can also be used for component A). According to the application, "precursor" means a substance which can be converted into a hydroxy-acid-containing substance useful in the application, for example by hydrolysis. Gluconolactone (glucoactanone) may be particularly exemplified as such precursor. For the purposes of the present application, especially considering that the composition according to the application is aqueous, such precursors may be considered to fall under the concept of "hydroxy acid containing".
According to a preferred embodiment of the application, the alpha-hydroxy acid is a lower monocarboxylic acid having 2 to 6 carbon atoms, such as lactic acid, gluconic acid or glycolic acid.
The component a) may be present in the composition in an amount ranging from 0.001 to 15 wt%, or from 0.01 to 10 wt%, preferably from 0.1 to 5 wt%, relative to the total weight of the composition according to the application.
Component B), nonionic surfactant
The composition according to the application may preferably comprise at least one nonionic surfactant, preferably selected from fatty acid esters of polyglycerols or fatty acid ethers of polyglycerols.
As component B) of the composition according to the application, mono-or polyglycerolated surfactants may be used, which preferably comprise an average of 1 to 30, more particularly 1 to 10, and in particular 1.5 to 5, glycerol groups.
The mono-or polyglycerolated surfactant is preferably selected from compounds of the formula:
R″O[CH 2 CH(CH 2 OH)O] m H,
R″O[CH 2 CH(OH)CH 2 O] m h or
R″O[CH(CH 2 OH)CH 2 O] m H;
In the formula:
r' represents a saturated or unsaturated, linear or branched hydrocarbon-based group containing from 8 to 40 carbon atoms and preferably from 10 to 30 carbon atoms; m is an integer between 1 and 30, preferably between 1 and 10 and more particularly between 1.5 and 6; r' may optionally contain heteroatoms such as oxygen and nitrogen. In particular, R "may optionally comprise one or more hydroxyl and/or ether and/or amide groups. R' preferably represents a monohydroxylated or polyhydroxylated C 10 -C 20 Alkyl and/or alkenyl groups.
Can be used, for example, by Chimex under the nameNF sold polyglycerolated (3.5 mol) hydroxy lauryl ether.
The (poly) ethoxylated fatty alcohols suitable for the practice of the present application are more particularly selected from alcohols containing from 8 to 30 carbon atoms, and preferably from 12 to 22 carbon atoms.
The (poly) ethoxylated fatty alcohols more particularly contain one or more linear or branched, saturated or unsaturated hydrocarbon-based groups containing from 8 to 30 carbon atoms, optionally substituted, in particular with one or more (in particular from 1 to 4) hydroxyl groups. If they are unsaturated, these compounds may contain 1 to 3 conjugated or non-conjugated carbon-carbon double bonds.
The (poly) ethoxylated fatty alcohols preferably have the following formula (XII):
wherein the method comprises the steps of
-R 3 Represents straight-chain or branched C 8 -C 40 Alkyl or alkenyl, and preferably C 8 -C 30 Alkyl or alkenyl, optionally substituted with one or more hydroxy groups, and
-c is an integer between 1 and 200 (inclusive), preferably between 2 and 50 and more particularly between 8 and 30, for example 20.
According to embodiments of the present application, the composition may comprise at least one fatty acid ester of polyglycerol for use as a nonionic surfactant.
According to a preferred embodiment, the fatty acid ester of polyglycerol is selected from esters resulting from the reaction of polyglycerol comprising 2 to 12 glycerol units, preferably 3 to 10 glycerol units, with at least one fatty acid containing 6 to 24 carbon atoms, preferably 8 to 20 carbon atoms, or 8 to 18 carbon atoms. Fatty acids containing 8 to 24 carbon atoms may be linear or branched, as well as saturated or unsaturated.
The fatty acid may be selected from oleic acid, stearic acid, isostearic acid, lauric acid, palmitic acid, myristic acid, linoleic acid, capric acid and caprylic acid, or mixtures thereof.
The fatty acid esters of polyglycerol may be selected from the group consisting of monoesters, diesters, triesters and tetraesters, polyesters and mixtures thereof. Preferably, esters with a low degree of esterification, such as fatty acid monoesters, diesters or triesters of polyglycerols, or mixtures are used. The fatty acid esters of polyglycerols may be in the form of mixtures of esters having a low degree of esterification (e.g., mixtures of monoesters and diesters or mixtures of monoesters, diesters and triesters).
Mention may be made in particular of polyglycerol-2 distearate, such as is sold under the name Emalex PGSA by NIHON EMULSION; polyglycerol-10 decastearate, such as in particular sold under the name sunoft Q-1810s by TAIYO KAGAKU; polyglycerol-5 hexastearate, such as in particular sold under the name sunoft a-186E by TAIYO KAGAKU; polyglycerol-2 laurate, in particular as sold under the name Sunsoft Q-12D by TAIYO KAGAKU; polyglycerol-5 laurate, such as is sold under the name Sunsoft A-121E-C by TAIYO KAGAKU; polyglycerol-10 pentaoleate, such as is sold under the name sunoft Q-175S by TAIYO KAGAKU; polyglycerol-10 pentastearate, such as in particular sold under the name sunoft Q-185S by TAIYO KAGAKU; polyglycerol-4 isostearate, particularly as sold under the name Isolan GI 34 by EVONIK GOLDSCHMIDT; diisostearoyl polyglycerol-3 dimerized linoleate, particularly as sold under the name Isolan PDI by EVONIK GOLDSCHMIDT; polyglycerol-2 oleate, such as in particular sold under the name sunoft Q-17B by TAIYO KAGAKU; polyglycerol-5 trimyristate esters, such as are sold under the name Sunsoft A-143E, in particular by TAIYO KAGAKU; polyglycerol-2 octanoate, in particular as sold under the name sunoft Q-81B by TAIYO KAGAKU; polyglycerol-6 dicaprate is particularly sold under the name SUNSOFT Q-102H-C by TAIYO KAGAKU.
Component B) may be present in the composition in an amount ranging from 0.1% to 20%, or from 0.5% to 10%, or from 1% to 5% relative to the total weight of the composition according to the application.
Component C), additional surfactant
For the purposes of the present application, the compositions according to the application may comprise, in addition to the surfactant used for component B), at least one additional surfactant as component C). According to an embodiment of the application, component C) may comprise component C-1), which is at least one amphoteric surfactant; component C-2), which is at least one anionic surfactant; and/or component C-3) which is at least one additional nonionic surfactant other than the nonionic surfactant used for component B).
Without being bound by any known theory, it is believed that the use of components B) and C) in combination may promote the function of component a) on the skin, such as the dissolution of intercellular lipid components. In particular, the simultaneous use of components B) and C) together with component A) may render the lipid more unstructured and more fluid, may create a synergistic effect to promote efficacy of the shedding and replacement of SCs, while relatively reducing irritation that may be caused by conventional surfactants.
Component C-1), amphoteric surfactant
According to an embodiment of the application, the composition according to the application comprises as component C-1) at least one amphoteric surfactant, which may also be referred to as zwitterionic surfactant.
Amphoteric or zwitterionic surfactants useful in the present application can be quaternized secondary or tertiary aliphatic amine derivatives containing at least one anionic group, e.g., carboxylate, sulfonate, sulfate, phosphate, or phosphonate group, and wherein the aliphatic group or at least one aliphatic group is a straight or branched chain containing from 8 to 22 carbon atoms.
Among the secondary or tertiary aliphatic amine derivatives which may be used, optionally quaternized, mention may also be made, as defined above, of the compounds of the following corresponding structures (III) and (IV):
in formula (III):
·R 4 represents an acid R derived from the acid preferably present in hydrolysed coconut oil 4 C of-C (O) -OH 10 -C 30 Alkyl or alkenyl, or heptyl, nonyl or undecyl;
·R 5 represents beta-hydroxyethyl; and
·R 6 represents carboxymethyl;
and
wherein:
a represents-CH 2 CH 2 OX′;
A' represents- (CH) 2 ) z-Y', wherein z=1 or 2;
x' represents a group-CH 2 -C(O)-OH、-CH 2 -C(O)-OZ′、-CH 2 CH 2 -C(O)-OH、-CH 2 -CH 2 -C (O) -OZ' or a hydrogen atom;
y 'represents-C (O) -OH, -C (O) -OZ' or a group-CH 2 -CH(OH)-SO 3 H or-CH 2 -CH(OH)-SO 3 Z′;
Z' represents an ion derived from an alkali metal or alkaline earth metal, such as sodium, potassium or magnesium; an ammonium ion; or ions derived from organic amines, and in particular from amino alcohols, such as monoethanolamine, diethanolamine and triethanolamine, monoisopropanolamine, diisopropanolamine or triisopropanolamine, 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1, 3-propanediol and tris (hydroxymethyl) aminomethane.
·R 7 Represents the acid R preferably present in coconut oil or hydrolysed linseed oil 7 C of C (O) -OH 10 -C 30 Alkyl or alkenyl, alkyl, especially C 17 Alkyl groups and isomeric forms thereof, or unsaturated C 17 A group.
By way of example, mention may be made of N-cocoamidocarboxymethyl glycinate of an alkali metal (for example sodium), or for example under the trade name by Rhodia companyCocoyl amphodiacetate sold as C2M concentrate.
Betaine surfactants, for example (C) 8 -C 20 ) Alkyl betaines, sulfobetaines, (C) 8 -C 20 Alkyl) amide group (C 2 -C 8 Alkyl) betaines and (C) 8 -C 20 Alkyl) amide group (C 2 -C 8 Alkyl) sulfobetaines.
Among all the amphoteric surfactants mentioned above, cocamidopropyl betaine, coco betaine and N-cocoamidocarboxymethyl glycinate of alkali metals (e.g. sodium) are preferably used.
According to a particular embodiment of the application, the amphoteric surfactant mentioned above is cocamidopropyl betaine or coco betaine.
Component C-2), anionic surfactant
According to an embodiment of the application, the composition according to the application comprises at least one anionic surfactant for use as component C-2).
The term "anionic surfactant" is understood to mean an amphiphilic compound having a hydrophobic portion and a hydrophilic portion, wherein the hydrophilic portion carries only anionic groups as ionic or ionizable groups and a cationic counterion, typically a metal (alkali metal, such as Na or K) or ammonium, which is capable of dissociating to provide anions in aqueous solution.
More particularly, the anionic groups of the anionic surfactant belong to the group selected from: c (O) OH, -C (O) O - 、-SO 3 H、-S(O) 2 O - 、-OS(O) 2 OH、-OS(O) 2 O - 、-P(O)OH 2 、-P(O) 2 O - 、-P(O)O 2 - 、-P(OH) 2 、=P(O)OH、-P(OH)O - 、=P(O)O - 、=POH、=PO - The cationic counterion is typically selected from alkali metals (e.g., sodium), or alkaline earth metals (e.g., magnesium), or organic cationic counterions (e.g., ammonium salts, amine salts, or amino alkoxides). The surfactants may also be present in their acid form.
As anionic surfactants, mention may be made of surfactants comprising carboxylate, sulfate, sulfonate, sulfoacetate, sulfosuccinate, phosphate, hydroxyethylsulfonate, sarcosinate, glutamate, lactoyl lactate or taurine anionic groups, salts of fatty acids, salts of galacturonic acid (galactosiduronic acid), salts of ether carboxylic acids and mixtures thereof.
More particularly, the anionic surfactant according to the application is selected from:
·(C 6 -C 30 ) Alkyl sulphates, (C) 6 -C 30 ) Alkyl ether sulphates, (C) 6 -C 30 ) Alkylamidoethyl sulfate, alkylaryl polyether sulfate or monoglyceride sulfate; for this type of anionic surfactant, it is preferable to use (C 6 -C 30 ) Alkyl ether sulfates, alkylaryl polyether sulfates, or mixtures. Mention may be made of lauryl alcohol containing 1 to 50 alkylene oxide groups and the sulphates of ethers of alkylene oxides.
·(C 6 -C 30 ) Alkyl sulfonate, (C) 6 -C 30 ) Alkylamide sulfonate, (C) 6 -C 30 ) Alkylaryl sulfonates, alpha-olefin sulfonates, paraffin sulfonates;
·(C 6 -C 30 ) Alkyl phosphates;
·(C 6 -C 30 ) Alkyl sulfosuccinates (C) 6 -C 30 ) Alkyl ether sulfosuccinates or (C) 6 -C 30 ) Alkylamidosuccinates;
·(C 6 -C 30 ) Alkyl sulfoacetates;
·(C 6 -C 24 ) Acyl sarcosinates;
·(C 6 -C 24 ) Acyl glutamate;
·(C 6 -C 30 ) Alkyl polyglycoside carboxylic acid ethers;
·(C 6 -C 30 ) Alkyl polyglycoside sulfosuccinates;
·(C 6 -C 30 ) Alkyl sulfosuccinamates;
·(C 6 -C 24 ) Acyl isethionates, such as sodium lauroyl methyl isethionate, sodium cocoyl isethionate; mention may be made of the products under the trade name of Innospec Active Chemicals companyLaurel sold by LQ-CLR-SBSodium acyl methyl isethionate;
·N-[(C 6 -C 24 ) Acyl group]Taurine salts;
salts of fatty acids;
·(C 8 -C 20 ) Acyl lactyllactate;
·(C 6 -C 30 ) Salts of alkyl-D-galacturonic acid;
·(C 6 -C 30 ) Salts of alkyl polyoxyalkylene ether carboxylic acids, (C) 6 -C 30 ) Salts of alkylaryl polyoxyalkylene ether carboxylic acids or (C) 6 -C 30 ) Salts of alkylamide-based polyoxyalkylene ether carboxylic acids;
and mixtures thereof.
The alkyl or acyl groups of these various anionic surfactants preferably contain 12 to 20 carbon atoms.
Furthermore, the oxyalkylenated or polyoxyalkylene anionic surfactant preferably comprises from 1 to 50 alkylene oxide groups, more preferably from 1 to 4 alkylene oxide groups, in particular ethylene oxide groups.
According to an embodiment of the application, the anionic surfactant is preferably selected from sodium laureth sulfate, sodium laurylmethylisethionate, sodium cocoyl isethionate, or mixtures thereof.
According to an embodiment of the application, the anionic surfactant is sodium laureth sulfate containing an average of 2.2 ethylene oxide groups.
According to a particularly exemplary embodiment of the present application, the composition may be free of any sulfate salt to be used as an anionic surfactant. For example, the anionic surfactant may be a taurate salt, such as sodium methyl stearyl taurate.
Component C-3), additional nonionic surfactant
According to an embodiment of the application, the composition according to the application comprises at least one additional nonionic surfactant in addition to the nonionic surfactant used for component B) in order to be used as component C-3).
Useful additional nonionic surfactantsExamples of (a) may comprise esters of polyols with fatty acids having saturated or unsaturated chains containing, for example, from 8 to 24 carbon atoms and better still from 12 to 22 carbon atoms, and their oxyalkylenated derivatives, i.e. derivatives containing oxyethylenated and/or oxypropylated units, for example their oxyalkylenated derivatives; c (C) 8 -C 24 Polyethylene glycol esters of fatty acids and oxyalkylenated derivatives thereof; c (C) 8 -C 24 Sorbitol esters of fatty acids and oxyalkylenated derivatives thereof; c (C) 8 -C 24 Sugar (sucrose, glucose or alkyl glucose) esters of fatty acids (fatty acid esters of glucose or alkyl glucose) and oxyalkylenated derivatives thereof; fatty alcohol ethers; c (C) 8 -C 24 Sugar ethers of fatty alcohols, and mixtures thereof.
Fatty acid esters of glucose or alkyl glucose which may be mentioned include in particular glucose palmitate; alkyl glucose sesquistearates, such as methyl glucose sesquistearate; alkyl glucose palmitate, such as methyl glucose palmitate or ethyl glucose palmitate; fatty esters of methyl glucoside, and more particularly diesters of methyl glucoside and oleic acid (CTFA name: methyl glucose dioleate); mixed esters of methyl glucoside and oleic acid/hydroxystearic acid mixture (CTFA name: methyl glucose dioleate/hydroxystearate); esters of methyl glucoside and isostearic acid (CTFA name: methyl glucose isostearate); esters of methyl glucoside and lauric acid (CTFA name: methyl glucose laurate); mixtures of monoesters and diesters of methyl glucoside and isostearic acid (CTFA name: methyl glucose sesquiisostearate); mixtures of monoesters and diesters of methyl glucoside and stearic acid (CTFA name: methyl glucose sesquistearate), and in particular by Amerchol company under the nameProducts sold by SS; and mixtures thereof.
Examples of oxyethylenated ethers of fatty acids and glucose or alkyl glucose that may be mentioned include oxyethylenated ethers of fatty acids and methyl glucose, and in particular methyl glucose and stearyl glucose containing about 20 moles of ethylene oxidePolyethylene glycol ethers of diesters of acids (CTFA name: PEG-20 methyl glucose distearate), e.g. by Amerchol company under the nameProducts sold as E-20 distearate; polyethylene glycol ethers of mixtures of monoesters and diesters of methyl glucose and stearic acid containing about 20 moles of ethylene oxide (CTFA name: PEG-20 methyl glucose sesquistearate), and in particular by Amerchol under the name>SSE-20, and is sold under the name GoldschmidtProducts sold by PSE-20; and mixtures thereof.
Examples of sucrose esters that may be mentioned include sucrose palmitostearate, sucrose stearate and sucrose monolaurate.
Examples of fatty alcohol ethers that may be mentioned include polyethylene glycol ethers of fatty alcohols containing from 8 to 30 carbon atoms and in particular from 10 to 22 carbon atoms, such as cetyl alcohol, stearyl alcohol or cetostearyl alcohol (mixtures of cetyl and stearyl alcohols). Examples which may be mentioned include ethers comprising from 1 to 200 and preferably from 2 to 100 oxyethylene groups, such as those having the CTFA name cetostearyl ether-20 and cetostearyl ether-30, and mixtures thereof.
Among the sugar ethers that may be mentioned are alkyl polyglucosides, such as decyl glucoside, for example, known by the name Kao Chemicals10, sold by Henkel under the name +.>2000, and by SEPPIC company under the name +.>NS 10 sells products; octyl/decyl glucoside, e.g. by SEPPIC company under the nameCG 110 or by BASF company under the name +.>A product sold by GD 70; lauryl glucoside, e.g. by Henkel company under the name +.>1200 N and->1200 products sold; coco glucosides, such as the product sold under the name plant 818/UP by Henkel corporation; cetyl-stearyl-glucoside optionally mixed with cetostearyl alcohol, e.g. by the company SEPPIC under the name +.>68. By Goldschmidt under the name +.>CG90 and by Henkel corporation under the name +.>KE3302 is sold; arachidyl glucosides, e.g. by SEPPIC company under the name +.>202 in the form of a mixture of arachidyl alcohol and behenyl alcohol and arachidyl alcohol glucoside; cocoylethyl glucosides, e.g. by the company SEPPIC under the name +.>82 with cetyl and stearyl alcohol (35/65); and mixtures thereof.
PEG modified esters such as PEG-7 olive oleate, PEG-7 glycerol cocoate, PEG-30 glycerol cocoate, PEG-80 glycerol cocoate can also be used.
Polysorbate families such as polysorbate 20, 21, 60, 61 and 80, or glyceride compounds such as caprylic acid glycerides (also known as monocaprylic acid glycerides), capric acid glycerides (also known as monocaprylic acid glycerides) and lauric acid glycerides (also known as monolaurate glycerides), such as PEG-6 caprylic/capric acid glycerides may additionally be mentioned as examples of useful additional nonionic surfactants.
For the purposes of the present application, at least one additional nonionic surfactant may itself act as a solubilizing agent to facilitate the dissolution or dispersion of the components in the aqueous composition.
Component C) may be present in the composition in a total amount ranging from 0.1 to 20 wt%, for example from 0.5 to 10 wt%, or from 1 to 5 wt%, relative to the total weight of the composition according to the application.
Medium/solvent
The composition according to the application may advantageously comprise at least one medium/solvent for use as component D), including water and/or organic medium/solvent.
Water and its preparation method
The composition according to the application may advantageously comprise various amounts of water. For low viscosity applications of the composition, relatively high amounts of water may be used, for example in the form of leave-on lotions. For example, water is used in an amount of greater than or equal to 40 wt.%, relative to the total weight of the composition. The water content in the low viscosity composition according to the present application preferably ranges from 40 wt% to 99 wt%, more preferably from 50 wt% to 90 wt%, or from 60 wt% to 80 wt%, relative to the total weight of the composition.
Organic medium/solvent
The composition according to the application may further comprise one or more organic media/solvents, preferably water-soluble organic media/solvents (solubility in water greater than or equal to 5% at 25 ℃ and atmospheric pressure).
Examples of organic media/solvents which may be mentioned include straight-chain or branched, and preferably saturated, monohydric alcohols or diols containing from 2 to 10 carbon atoms, such as ethanol, (isopropanol), butanol, hexanediol (2-methyl-2, 4-pentanediol), neopentyl glycol and 3-methyl-1, 5-pentanediol, butanediol, dipropylene glycol and propylene glycol; aromatic alcohols such as phenethyl alcohol; polyols containing more than two hydroxyl functions, in particular C3-C6 polyols, such as glycerol; polyhydric alcohol ethers such as ethylene glycol monomethyl ether, monoethyl ether and monobutyl ether, propylene glycol or ethers thereof such as propylene glycol monomethyl ether; and diethylene glycol alkyl ethers, especially C 1 -C 4 Alkyl ethers, such as diethylene glycol monoethyl ether or monobutyl ether, alone or in mixtures.
The organic medium/solvent, when they are present, ranges from 0.1% to 40% by weight, preferably from 1% to 30% by weight, or from 5% to 20% by weight, relative to the total weight of the composition according to the application.
Preservative agent
For the use according to the application, the composition according to the application may optionally comprise a preservative. The preservative useful according to the application can be any of those conventionally used in cosmetics, in particular for ampoule products.
For example, preservatives that may be used in accordance with the present application include methyl chloroisothiazolinone, imidazolidinyl urea, derivatives of hydantoin (e.g., DMDMH), parabens, phenoxyethanol, benzyl alcohol, chlorophenylglycol ether, benzoic acid and derivatives thereof, such as salts thereof (e.g., sodium benzoate), potassium sorbate, hydroxyacetophenone, amino acid-based preservatives, sorbitan octanoate, glycerol octanoate, and the like, or salicylic acid.
The preservative may be present according to the application in an amount ranging from 0.01 to 5%, preferably from 0.01% to 3%, or from 0.01% to 1%, relative to the total weight of the composition of the application.
Chelating agent
According to a particularly advantageous embodiment, the composition may comprise a chelating agent. Such Chelating agents are particularly defined and described in the publication "Chelating agents" Kirk Othmer Encyclopedia of Chemical Technology, volume 5, pages 708-739, published 2003.
As described herein, as examples of chelating agents are polyphosphates, aminocarboxylic acids, 1, 3-diketones, hydroxycarboxylic acids, polyamines, aminoalcohols, heterocyclic aromatic bases, aminophenols, schiff bases, tetrapyrroles, sulfur compounds, synthetic macrocyclic compounds, polymers and phosphonic acids.
Useful chelating agents for the purposes of the present application may include ethylenediamine tetraacetic acid (EDTA), aminotriacetic acid, diethylenetriamine pentaacetic acid, and salts thereof, such as N, N-bis (carboxymethyl) glutamic acid, disodium EDTA, tetrasodium EDTA, the tetrasodium salt of N, N-bis (carboxymethyl) glutamic acid (glutamic diacetic acid, GLDA); hydroxycarboxylic acids such as citric acid, tartaric acid, glucuronic acid, succinic acid, ethylenediamine disuccinic acid (EDDS), and salts thereof; hydroxy amino carboxylic acids such as hydroxyethyl ethylenediamine triacetic acid (HEDTA), dihydroxyethyl glycine (DEG), and salts thereof; polyphosphonic acids, and salts thereof; other phosphorus-containing organic acids, such as phytic acid, and salts thereof, such as sodium phytate, potassium phytate; polycarboxylic acids such as polyacrylic acid, polymethacrylic acid, and salts thereof.
These agents are particularly useful for reducing electrostatic bonding with water present in substantial amounts in the intermediate make-up and/or care compositions according to the present application. For this purpose, the addition of chelating or complexing agents (for example disodium EDTA/tetrasodium EDTA) makes it possible to complex the free ions and more particularly the Ca present in particular in the mother-of-pearl and in the fillers 2+ Cations (mineral fillers). Therefore, when EDTA complexes these ions, the ionic strength of water decreases. Preferably, such agents are selected from amino carboxylic acids, and preferably EDTA or derivatives thereof.
For example, useful chelating agents are selected from the group consisting of sodium citrate, disodium EDTA, tetrasodium GLDA, trisodium EDDS, phytic acid, sodium phytate, potassium phytate, and mixtures thereof.
According to the application, the chelating agent may be present in the composition according to the application in an amount of 0.001 to 5 wt%, preferably 0.01 to 0.1 wt%, or preferably 0.1 to 0.5 wt%, relative to the total weight of the composition according to the application.
Polysaccharide
The composition according to the application may comprise at least one polysaccharide, preferably of biotechnological origin.
In particular, where appropriate, these polysaccharides may be chemically modified to increase their hydrophilic valences (hydrophilic valency), as in the case of cellulose derivatives, in particular hydroxyalkyl celluloses (e.g. hydroxyethyl cellulose).
As examples of polysaccharides which can be used according to the application, mention may be made in particular of:
a) Algae extracts, such as alginate, carrageenan, and agar, and mixtures thereof. Examples of carrageenans that may be mentioned include satiagnum from Degussa companyAnd->Alginate which may be mentioned is +.A. by ISP company under the name +.>Sodium alginate sold;
b) Gums (gum), such as xanthan gum, gellan gum, guar gum and nonionic derivatives thereof (hydroxypropyl guar), acacia, konjac or mannan gum, tragacanth gum, gum ghatti, karaya gum, locust bean gum, agar gum, sclerotium gum and mixtures thereof; examples that may be mentioned include those named by CP Kelco corporationXanthan gum sold by CG-T under the name +.>Gellan gum sold by CG LA under the name Jaguar ++by Rhodia corporation>Guar gum sold, mannans gum sold by company GfN and +.>(1% glucomannan);
c) Starch, which is preferably modified, such as, for example, those derived from: grains, such as wheat, corn or rice; legumes, such as white hyacinth beans; tubers, such as potatoes or tapioca; tapioca starch; dextrins, such as corn dextrins; amidon de from Roquette CorpPotato Starch modified with 2-chloroethylaminodipropionic acid neutralized with sodium hydroxide, under the name Structure +.>Selling; by National Starch company under the name Tapioca->Natural tapioca starch powder for sale;
d) Dextrins, e.g. from National Starch company under the nameIs extracted from corn;
e) Cellulose and its derivatives, in particular alkyl or hydroxyalkyl celluloses; in particular, methylcellulose, hydroxyalkyl cellulose, ethylhydroxyethyl cellulose and carboxymethyl cellulose may be mentioned. Examples which may be mentioned include those sold under the name Natrosol by Ashland Corp TM 250 HHR PC sold under the name Cellosize by Amerchol (Dow Chemical) company TM Hydroxyethyl cellulose sold by QP 4400H from Aqualon under the name PolysurfAnd Natrosol Plus->Cetyl hydroxyethylcellulose is sold;
f) Pectin;
g) Chitosan and derivatives thereof;
h) Polysaccharides (polyholoside) comprising at least two sugars, preferably of natural origin and chosen in particular from:
aldoses, e.g.
Pentose sugar: such as ribose, arabinose, xylose or apiose,
hexose: such as glucose, fucose, mannose or galactose,
ketose, for example fructose,
deoxysugars, such as rhamnose, digitoxin, magnetic-hemp or oleanolic fructose,
sugar derivatives, such as uronic acid, e.g. mannuronic acid, guluronic acid, galacturonic acid or glucuronic acid, or sugar alcohols, e.g. mannitol or sorbitol.
Mention may be made in particular of polysaccharides comprising fucose, galactose and galacturonic acid units, and linear sequences of, for example, alpha-L-fucose, alpha-D-galactose and galacturonic acid, for example, under the trade name Solaba corporation1000 PP or1.5P biological sugar gum-1 sold,
i) Anionic polysaccharides, in particular of biotechnological origin, for example those with tetraose consisting of L-fucose, D-glucose and glucuronic acid as repeating units, for example the product sold under the designation Biosugar-4 by Solaba company under the designation Glycofilm 1.5P,
j) And mixtures thereof.
Preferably, the polysaccharide of the application is selected from:
gums, such as xanthan gum or gellan gum;
cellulose and its derivatives, such as hydroxyethyl cellulose;
polysaccharides comprising fucose, galactose and galacturonic acid units, such as biose-1.
According to embodiments, the polysaccharide, e.g., according to embodiments, may also act as a gelling agent for the compositions of the present application.
According to an embodiment, the polysaccharide may be present in the composition in an amount ranging from 0.0001 wt% to 5 wt%, preferably from 0.001 wt% to 2 wt%, more preferably from 0.005 wt% to 1 wt% of the polysaccharide, relative to the total weight of the composition.
Additional active ingredient
The composition according to the application may advantageously comprise one or more additional active ingredients, in particular cosmetic, dermatological or pharmaceutical active ingredients.
In the context of the present application, additional active ingredients are active ingredients other than polydatin or resveratrol present in the composition and other active agents specifically defined above.
Advantageously, such additional active ingredients (cosmetic, dermatological or pharmaceutical active ingredients) may be intended to exert a cosmetic, care or hygiene effect on keratin materials such as skin (including the face), hair, eyelashes, scalp and/or leather hair, and preferably on the skin.
The choice of such additional active ingredients is of course governed by the effect jointly sought by the relevant compositions.
Thus, the composition according to the present application may further comprise an active ingredient having anti-aging activity or hydration activity.
Of course, the person skilled in the art will carefully choose the optional additional active ingredient added to the composition according to the application in such a way that the inherent attendant advantageous properties of the composition according to the application are not or substantially not altered by the proposed addition.
These additional active ingredients are generally present in the composition in an amount ranging from 0.0001% to 20% by weight, and preferably from 0.01% to 10% by weight, relative to the total weight of the composition.
Additive agent
According to various embodiments, the compositions of the present application are provided for application to the skin. According to these embodiments, the compositions of the present application may comprise various ingredients commonly used in conditioning dermatological compositions, such as moisturizers, fatty substances, antidandruff agents, anti-seborrheic agents, agents to prevent loss and/or promote regeneration, vitamins and provitamins (including panthenol), sunscreens, chelators, plasticizers, acidulants, opacifiers, pearlescers (pearlescent or nacreous agent), antioxidants, hydroxy acids, fragrances, and preservatives.
A non-exhaustive list of such ingredients can be found in U.S. patent application publication No. 2004/0170586, the entire contents of which are incorporated herein by reference. Further examples of such additional ingredients can be found in International Cosmetic Ingredient Dictionary and Handbook (9 th edition, 2002).
The person skilled in the art will take care to choose the optional additional additives and/or the amounts thereof such that the addition considered does not or substantially not adversely affect the advantageous properties of the composition according to the application.
These additives can be variously selected by those skilled in the art to prepare compositions having desired properties (e.g., consistency or texture). In particular, the additives (if used) and their amounts are determined in particular according to the particular product/application (e.g., leave-on conditioner, rinse-off conditioner, skin care conditioner, etc.).
These additives may be present in the composition in an amount of 0.01% to 50% relative to the total weight of the composition, including all ranges and subranges therebetween.
Method and use
The compositions according to the application can generally be prepared according to the general knowledge of the person skilled in the art. Nevertheless, it is understood that the skilled person can choose the preparation method on the basis of his general knowledge, taking into account the nature of the ingredients used, for example their solubility in the carrier and the application envisaged for the composition or kit.
According to embodiments, the composition according to the application may be used for caring skin. The use may manifest itself in a method for caring for the skin comprising the step of applying the composition of the application to said skin.
The composition according to the application is preferably useful for formulating skin care products. Furthermore, from the detailed discussion above, it is understood that the compositions according to the present application may be free of silicone oil.
The present application thus provides the use of at least one fatty acid ester of polyglycerol or fatty acid ether of polyglycerol according to component B) in combination with another surfactant, for example one or more surfactants according to component C), for enhancing the performance of hydroxyl-containing acids while avoiding or reducing skin irritation, in particular irritation caused by the acid component and/or any conventional surfactants contained in cosmetic and/or therapeutic compositions. For example, the surfactant combination may be mixed with a cosmetic and/or therapeutic composition comprising a stimulating acid prior to application; alternatively, the surfactant combination may be applied to the skin before or after the application of the cosmetic and/or therapeutic composition comprising the irritating acid.
The application will be further illustrated by the following examples, which illustrate particularly advantageous embodiments.
Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the application are approximations, the numerical values set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements. The following examples are intended to illustrate the application and are not thereby limiting in scope.
Examples
The amounts/concentrations of ingredients in the following compositions/formulations are expressed in weight percent relative to the total weight of each composition/formulation.
Materials:
lactic acid: LACTIC ACID 90, available from MUSASHINOCHEMICAL LABORATORY;
PEG-7 glycerol cocoate: CETIOL HE available from BASF;
polyglycerol-5 laurate: SUNSOFT A-121E-C, available from TAIYO KAGAKU; and
other materials not described herein are each commercially available.
Example I preparation of the composition
Compositions were prepared according to examples 1-3 and comparative examples 1-3 in table 1 below:
TABLE 1
The compositions listed above are prepared according to manufacturing methods known in the art. Briefly, the procedure for preparing the composition included the following steps:
1) Dissolving lactic acid, salicylic acid and glycerol in hot water at 70deg.C, and mixing until completely dissolving;
2) Adding xanthan gum and mixing until no lumps are observed, and then cooling to room temperature; and is combined with
3) Adding the other components one by one in any order.
Example II
Determining the effect of a composition on cell viability, comprising the steps of: an effective amount of the composition is applied to the reconstructed skin model, allowed to stand and then counted for viable cell mass. The higher the vitality means the higher the comfort.
In addition, the efficacy of the compositions was tested by a panel of 60 persons using the following protocol:
60 chinese females, 22-45 years old, all skin types, self-claim rough and dull skin, lack gloss, medium to dark skin with fine lines/wrinkles under the eye area;
test time: week 0, week 2, week 3;
-scoring method: skin smoothness was scored at each "test time" using a dermatologist scale known in the art.
Sebum migration results are provided as follows:
TABLE 2
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Claims (15)
1. A composition for conditioning skin comprising the following components:
a) At least one hydroxy-containing acid selected from the group consisting of alpha-hydroxy acids, preferably lower acids having 2 to 12 carbon atoms, or 2 to 8 carbon atoms, or 2 to 6 carbon atoms, gluconic acid, lactobionic acid and salicylic acid, or precursors thereof;
b) At least one nonionic surfactant selected from fatty acid esters of polyglycerols or fatty acid ethers of polyglycerols; and
c) At least one additional surfactant other than component B).
2. The composition of claim 1 wherein said component a) is a monocarboxylic acid.
3. The composition according to claim 1 or 2, wherein the component a) comprises glycolic acid, lactic acid, malic acid, gluconic acid, lactobionic acid, citric acid, tartaric acid and salicylic acid, preferably lactic acid, gluconic acid or glycolic acid.
4. The composition according to any of the preceding claims, wherein the component a) is present in an amount ranging from 0.001 to 15 wt%, preferably from 0.01 to 10 wt%, or from 0.1 to 5 wt%, relative to the total weight of the composition.
5. The composition according to any of the preceding claims, wherein said component B) is selected from esters resulting from the reaction of polyglycerols comprising from 2 to 12 glycerol units, preferably from 3 to 10 glycerol units, and at least one fatty acid containing from 6 to 24 carbon atoms, preferably from 8 to 20 carbon atoms, or from 8 to 18 carbon atoms.
6. The composition according to any of the preceding claims, wherein the component B) is present in the composition in an amount of 0.1% to 20%, preferably 0.5% to 10%, or 1% to 5% relative to the total weight of the composition.
7. The composition according to any of the preceding claims, wherein component C) comprises component C-1), at least one amphoteric surfactant selected from (C) 8 -C 20 ) Alkyl betaines, sulfobetaines, (C) 8 -C 20 Alkyl) amide group (C 2 -C 8 Alkyl) betaines and (C) 8 -C 20 Alkyl) amide group (C 2 -C 8 Alkyl) sulfobetaines.
8. The composition according to any of the preceding claims, wherein component C) comprises component C-2), at least one anionic surfactant selected from anionic surfactants, surfactants comprising carboxylate, sulfate, sulfonate, sulfoacetate, sulfosuccinate, phosphate, hydroxyethylsulfonate, sarcosinate, glutamate, lactate or taurate anionic groups, salts of fatty acids, salts of galacturonic acid, salts of ether carboxylic acids and mixtures thereof.
9. The composition according to any of the preceding claims, wherein component C) comprises component C-3), at least one additional nonionic surfactant selected from the group consisting of fatty acid esters of glucose or alkyl glucose, fatty acids and oxyethylenated ethers of glucose or alkyl glucose, sugar ethers, PEG-modified esters, polysorbate series and glyceride compounds, in addition to the nonionic surfactant used for component B); such as coco glucoside, PEG-7 glycerol cocoate, PEG-30 glycerol cocoate, PEG-80 glycerol cocoate, polysorbate 20 or 21, glyceryl caprylate, glyceryl caprate, glyceryl laurate or PEG-6 caprylate/caprate.
10. The composition according to any of the preceding claims, wherein the component C) is present in the composition in an amount ranging from 0.1 to 20 wt%, preferably from 0.5 to 10 wt%, or from 1 to 5 wt%, relative to the total weight of the composition.
11. The composition of any one of the preceding claims, further comprising at least one chelating agent selected from the group consisting of sodium citrate, disodium EDTA, tetrasodium GLDA, trisodium EDDS, phytic acid, sodium phytate, potassium phytate, and mixtures thereof.
12. The composition according to claim 11, wherein the chelating agent is present in an amount ranging from 0.001 to 5 wt%, preferably from 0.01 to 0.1 wt%, or preferably from 0.1 to 0.5 wt%, relative to the total weight of the composition according to the application.
13. The composition according to any one of the preceding claims, further comprising at least one polysaccharide selected from gums such as xanthan gum or gellan gum; cellulose and its derivatives, such as hydroxyethyl cellulose; polysaccharides comprising fucose, galactose and galacturonic acid units, such as biose-1.
14. The composition according to claim 13, wherein the polysaccharide is present in an amount ranging from 0.0001 to 5 wt%, preferably from 0.001 to 2 wt%, or from 0.005 to 1 wt% of the polysaccharide, relative to the total weight of the composition.
15. Use of component B), at least one fatty acid ester of polyglycerol or fatty acid ether of polyglycerol, in combination with a surfactant of component C) for avoiding or reducing irritation suffered by the skin, in particular by any acid component contained in a cosmetic and/or therapeutic composition, said component C) being selected from:
c-1) at least one amphoteric surfactant;
c-2) at least one anionic surfactant; and
c-3) at least one additional nonionic surfactant other than the nonionic surfactant used for component B).
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US6168798B1 (en) * | 1997-02-03 | 2001-01-02 | Bristol-Myers Squibb Company | Non-irritating composition for treating acne and other skin conditions |
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