CN116925224A - 抗cd39纳米抗体及其应用 - Google Patents

抗cd39纳米抗体及其应用 Download PDF

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Publication number
CN116925224A
CN116925224A CN202210345704.7A CN202210345704A CN116925224A CN 116925224 A CN116925224 A CN 116925224A CN 202210345704 A CN202210345704 A CN 202210345704A CN 116925224 A CN116925224 A CN 116925224A
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China
Prior art keywords
antigen
ser
gly
val
seq
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Pending
Application number
CN202210345704.7A
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English (en)
Chinese (zh)
Inventor
张振清
贾云莉
徐祎凤
缪小牛
李志远
曾竣玮
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Biotheus Inc
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Biotheus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotheus Inc filed Critical Biotheus Inc
Priority to CN202210345704.7A priority Critical patent/CN116925224A/zh
Priority to IL315999A priority patent/IL315999A/en
Priority to US18/853,158 priority patent/US20250230255A1/en
Priority to JP2025503025A priority patent/JP2025513930A/ja
Priority to PCT/CN2023/085567 priority patent/WO2023186121A1/en
Priority to CA3246718A priority patent/CA3246718A1/en
Priority to AU2023247720A priority patent/AU2023247720A1/en
Priority to CN202380031836.5A priority patent/CN119013298A/zh
Priority to KR1020247035805A priority patent/KR20250017205A/ko
Priority to EP23778485.5A priority patent/EP4504789A1/en
Publication of CN116925224A publication Critical patent/CN116925224A/zh
Priority to CL2024002926A priority patent/CL2024002926A1/es
Priority to MX2024012216A priority patent/MX2024012216A/es
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
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    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)

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  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Food Science & Technology (AREA)
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CN202210345704.7A 2022-04-02 2022-04-02 抗cd39纳米抗体及其应用 Pending CN116925224A (zh)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CN202210345704.7A CN116925224A (zh) 2022-04-02 2022-04-02 抗cd39纳米抗体及其应用
CA3246718A CA3246718A1 (en) 2022-04-02 2023-03-31 ANTI-CD39 NANOBORPS AND THEIR USES
US18/853,158 US20250230255A1 (en) 2022-04-02 2023-03-31 Anti-cd39 nanobody and uses thereof
JP2025503025A JP2025513930A (ja) 2022-04-02 2023-03-31 抗ｃｄ３９ナノボディ及びその使用
PCT/CN2023/085567 WO2023186121A1 (en) 2022-04-02 2023-03-31 Anti-cd39 nanobody and uses thereof
IL315999A IL315999A (en) 2022-04-02 2023-03-31 ANTI-CD39 nanoantibody and its uses
AU2023247720A AU2023247720A1 (en) 2022-04-02 2023-03-31 Anti-cd39 nanobody and uses thereof
CN202380031836.5A CN119013298A (zh) 2022-04-02 2023-03-31 抗cd39纳米抗体及其应用
KR1020247035805A KR20250017205A (ko) 2022-04-02 2023-03-31 항-cd39 나노바디 및 이의 용도
EP23778485.5A EP4504789A1 (en) 2022-04-02 2023-03-31 Anti-cd39 nanobody and uses thereof
CL2024002926A CL2024002926A1 (es) 2022-04-02 2024-09-30 Nanocuerpo anti-cd39 y usos del mismo
MX2024012216A MX2024012216A (es) 2022-04-02 2024-10-02 Nanocuerpo anti-cd39 y usos del mismo

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210345704.7A CN116925224A (zh) 2022-04-02 2022-04-02 抗cd39纳米抗体及其应用

Publications (1)

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CN116925224A true CN116925224A (zh) 2023-10-24

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CN202210345704.7A Pending CN116925224A (zh) 2022-04-02 2022-04-02 抗cd39纳米抗体及其应用
CN202380031836.5A Pending CN119013298A (zh) 2022-04-02 2023-03-31 抗cd39纳米抗体及其应用

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US (1) US20250230255A1 (https=)
EP (1) EP4504789A1 (https=)
JP (1) JP2025513930A (https=)
KR (1) KR20250017205A (https=)
CN (2) CN116925224A (https=)
AU (1) AU2023247720A1 (https=)
CA (1) CA3246718A1 (https=)
CL (1) CL2024002926A1 (https=)
IL (1) IL315999A (https=)
MX (1) MX2024012216A (https=)
WO (1) WO2023186121A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117986364A (zh) * 2023-12-27 2024-05-07 华润生物医药有限公司 特异性结合cd39的纳米抗体及其用途
CN119930816A (zh) * 2023-11-02 2025-05-06 广东菲鹏制药股份有限公司 抗cd39人源化抗体或其抗原结合片段及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108299561B (zh) * 2018-01-02 2020-11-13 暨南大学 一种pd-1纳米抗体及其克隆表达方法与应用
CA3149494A1 (en) * 2019-08-12 2021-02-18 Purinomia Biotech, Inc. Methods and compositions for promoting and potentiating t-cell mediated immune responses through adcc targeting of cd39 expressing cells
CN110407941B (zh) * 2019-09-25 2020-01-14 上海岸迈生物科技有限公司 Cd39的高亲和力抗体及其用途
CN115551888B (zh) * 2020-05-12 2026-04-28 百欧恩泰(珠海)医药研发有限公司 抗cd73抗体及其用途
JP2023532234A (ja) * 2020-06-22 2023-07-27 イノベント バイオロジクス（スーチョウ）カンパニー，リミティド 抗ｃｄ７３抗体とその用途
WO2022237723A1 (zh) * 2021-05-12 2022-11-17 杭州邦顺制药有限公司 抗cd39抗体及其制备方法和用途

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119930816A (zh) * 2023-11-02 2025-05-06 广东菲鹏制药股份有限公司 抗cd39人源化抗体或其抗原结合片段及其应用
CN117986364A (zh) * 2023-12-27 2024-05-07 华润生物医药有限公司 特异性结合cd39的纳米抗体及其用途

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AU2023247720A1 (en) 2024-10-10
CN119013298A (zh) 2024-11-22
EP4504789A1 (en) 2025-02-12
KR20250017205A (ko) 2025-02-04
MX2024012216A (es) 2025-01-09
WO2023186121A1 (en) 2023-10-05
CL2024002926A1 (es) 2025-02-21
US20250230255A1 (en) 2025-07-17
CA3246718A1 (en) 2023-10-05
IL315999A (en) 2024-11-01
JP2025513930A (ja) 2025-04-30

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