CN116916922B - (s,e)-4-(二甲胺基)-n-(3-(4-(2-羟基-1-苯乙胺基)-6-苯基呋喃并[2,3-d]嘧啶-5-基)苯基)丁-2-烯酰胺游离碱的晶型 - Google Patents

(s,e)-4-(二甲胺基)-n-(3-(4-(2-羟基-1-苯乙胺基)-6-苯基呋喃并[2,3-d]嘧啶-5-基)苯基)丁-2-烯酰胺游离碱的晶型

Info

Publication number
CN116916922B
CN116916922B CN202280009812.5A CN202280009812A CN116916922B CN 116916922 B CN116916922 B CN 116916922B CN 202280009812 A CN202280009812 A CN 202280009812A CN 116916922 B CN116916922 B CN 116916922B
Authority
CN
China
Prior art keywords
cancer
crystal form
abt
pharmaceutical composition
free base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202280009812.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN116916922A (zh
Inventor
徐祖安
谢兴邦
张书铭
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anbang Biotechnology Co ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CN116916922A publication Critical patent/CN116916922A/zh
Application granted granted Critical
Publication of CN116916922B publication Critical patent/CN116916922B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202280009812.5A 2021-07-06 2022-07-06 (s,e)-4-(二甲胺基)-n-(3-(4-(2-羟基-1-苯乙胺基)-6-苯基呋喃并[2,3-d]嘧啶-5-基)苯基)丁-2-烯酰胺游离碱的晶型 Active CN116916922B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163218504P 2021-07-06 2021-07-06
US63/218,504 2021-07-06
PCT/US2022/036260 WO2023283269A1 (en) 2021-07-06 2022-07-06 Crystalline forms of (s, e)-4-(dimethylamino)-n-(3-(4-(2-hydroxy-1-phenylethylamino)-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl)but-2-enamide free base

Publications (2)

Publication Number Publication Date
CN116916922A CN116916922A (zh) 2023-10-20
CN116916922B true CN116916922B (zh) 2026-01-02

Family

ID=84802010

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280009812.5A Active CN116916922B (zh) 2021-07-06 2022-07-06 (s,e)-4-(二甲胺基)-n-(3-(4-(2-羟基-1-苯乙胺基)-6-苯基呋喃并[2,3-d]嘧啶-5-基)苯基)丁-2-烯酰胺游离碱的晶型

Country Status (12)

Country Link
US (2) US12240858B2 (https=)
EP (1) EP4330259A4 (https=)
JP (1) JP7565118B2 (https=)
KR (1) KR102783648B1 (https=)
CN (1) CN116916922B (https=)
AU (1) AU2022307875B2 (https=)
BR (1) BR112023024853A2 (https=)
CA (1) CA3217088A1 (https=)
IL (1) IL308946B2 (https=)
MX (1) MX2023013093A (https=)
TW (1) TWI809967B (https=)
WO (1) WO2023283269A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI906763B (zh) * 2024-02-05 2025-12-01 財團法人國家衛生研究院 表皮生長因子受體抑制劑

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011099764A2 (en) * 2010-02-09 2011-08-18 Hanmi Holdings Co., Ltd. Novel pyrimidine derivative for inhibiting the growth of cancer cells
CN102264745A (zh) * 2008-11-10 2011-11-30 财团法人卫生研究院 作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102264745A (zh) * 2008-11-10 2011-11-30 财团法人卫生研究院 作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物
WO2011099764A2 (en) * 2010-02-09 2011-08-18 Hanmi Holdings Co., Ltd. Novel pyrimidine derivative for inhibiting the growth of cancer cells

Also Published As

Publication number Publication date
TW202309041A (zh) 2023-03-01
JP2024514995A (ja) 2024-04-04
US12240858B2 (en) 2025-03-04
IL308946A (en) 2024-01-01
KR102783648B1 (ko) 2025-03-18
IL308946B2 (en) 2026-01-01
CA3217088A1 (en) 2023-01-12
BR112023024853A2 (pt) 2024-02-15
CN116916922A (zh) 2023-10-20
TWI809967B (zh) 2023-07-21
WO2023283269A1 (en) 2023-01-12
AU2022307875A1 (en) 2023-11-02
AU2022307875B2 (en) 2024-08-01
US20230021909A1 (en) 2023-01-26
EP4330259A4 (en) 2024-10-09
KR20230118963A (ko) 2023-08-14
EP4330259A1 (en) 2024-03-06
JP7565118B2 (ja) 2024-10-10
IL308946B1 (en) 2025-09-01
US20240368175A1 (en) 2024-11-07
MX2023013093A (es) 2024-04-09

Similar Documents

Publication Publication Date Title
US20230167128A1 (en) Polymorphs and solid forms of (s)-2-((2-((s)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide, and methods of production
JP4456079B2 (ja) ｛６，７−ビス（２−メトキシ−エトキシ）−キナゾリン−４−イル｝−（３ｅ）の多形体
CN108349978A (zh) (S)-4-(8-氨基-3-(1-(丁-2-炔酰基)吡咯烷-2-基)咪唑并[1,5-a]吡嗪-1-基)-N-(吡啶-2-基)苯甲酰胺的固体形式和制剂
US12269813B2 (en) Crystalline form of 1-(1-oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluoromethyl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-pyrazole-4-carboxamide monohydrate
JP2018039807A (ja) 結晶形態の（Ｓ）−４−アミノ−Ｎ−（１−（４−クロロフェニル）−３−ヒドロキシプロピル）−１−（７Ｈ−ピロロ［２，３−ｄ］−ピリミジン−４−イル）ピペリジン−４−カルボキサミド
CN116916922B (zh) (s,e)-4-(二甲胺基)-n-(3-(4-(2-羟基-1-苯乙胺基)-6-苯基呋喃并[2,3-d]嘧啶-5-基)苯基)丁-2-烯酰胺游离碱的晶型
CN107793363B (zh) 一种取代芳胺基芳杂环类化合物及其作为抗肿瘤药物的应用
RU2658009C2 (ru) Полиморфы 2-(4-(2-(1-изопропил-3-метил-1h-1,2,4-триазол-5-ил)-5,6-дигидробензо[f]имидазо[1,2-d][1,4]оксазепин-9-ил)-1н-пиразол-1-ил)-2-метилпропанамида, способы их получения и фармацевтические применения
US10858348B2 (en) Salt forms of 4-cyano-N-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-Tetr amethyltetrahydro-2H-pyran-4-yl)pyridin-3-yl)-1H-imidazole-2-carboximide
RU2851691C2 (ru) Кристаллические формы свободного основания (S,E)-4-(диметиламино)-N-(3-(4-(2-гидрокси-1-фенилэтиламино)-6-фенилфуро[2,3-d]пиримидин-5-ил)фенил)бут-2-енамида
US20240197680A1 (en) Voruciclib dosing regimens and methods of treatment including the same
HK40094095A (zh) (s，e)-4-(二甲胺基)-n-(3-(4-(2-羟基-1-苯乙胺基)-6-苯基呋喃并[2，3-d]嘧啶-5-基)苯基)丁-2-烯醯胺游离硷的晶型
TW202517624A (zh) Mek免疫腫瘤抑制劑醫藥組合物
US20240270733A1 (en) Hydrate form of lazertinib mesylate, preparation method thereof and use thereof
AU2017299506A1 (en) Crystalline forms of 4-cyano-N-(2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)pyridin-3-yl)-1H-imidazole-2-carboxamide
KR20250098089A (ko) 퀴나졸린 유도체 화합물의 신규한 염 및 이의 제조방법
CN120344512A (zh) 氧异吲哚-5-甲酰胺类化合物或其盐、溶剂合物的结晶形式或无定形形式
HK40102219A (zh) 沃鲁西林给药方案和包含所述方案的治疗方法
CN119638675A (zh) 一种嘧啶苯胺类化合物的晶型、制备方法及应用
HK1223101B (zh) Gdc-0032的多晶型物、其制备方法和药物用途

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40094095

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant
TR01 Transfer of patent right

Effective date of registration: 20260123

Address after: China Taiwan Taipei City Nangang District Academia Road Section 1 Lane 130 No. 99 Building C 5th Floor

Patentee after: Anbang Biotechnology Co.,Ltd.

Country or region after: Taiwan, China

Address before: Taiwan, Taipei, China

Patentee before: Shi Quan

Country or region before: U.S.A.

TR01 Transfer of patent right