CN116904034A - Positioning film, preparation method and application - Google Patents
Positioning film, preparation method and application Download PDFInfo
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- CN116904034A CN116904034A CN202310816644.7A CN202310816644A CN116904034A CN 116904034 A CN116904034 A CN 116904034A CN 202310816644 A CN202310816644 A CN 202310816644A CN 116904034 A CN116904034 A CN 116904034A
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- silicone oil
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- positioning
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- 238000002360 preparation method Methods 0.000 title abstract description 12
- 229920002545 silicone oil Polymers 0.000 claims abstract description 50
- 239000002994 raw material Substances 0.000 claims abstract description 46
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 37
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims abstract description 33
- 229920002554 vinyl polymer Polymers 0.000 claims abstract description 33
- 239000003054 catalyst Substances 0.000 claims abstract description 19
- 239000001257 hydrogen Substances 0.000 claims abstract description 17
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 17
- 239000003607 modifier Substances 0.000 claims abstract description 17
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 16
- 238000001959 radiotherapy Methods 0.000 claims abstract description 11
- 150000002431 hydrogen Chemical class 0.000 claims abstract description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims description 24
- 238000009417 prefabrication Methods 0.000 claims description 18
- 239000012295 chemical reaction liquid Substances 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 11
- 238000006243 chemical reaction Methods 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- 238000000227 grinding Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000000419 plant extract Substances 0.000 claims description 3
- 229920001661 Chitosan Polymers 0.000 claims description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 2
- 239000011976 maleic acid Substances 0.000 claims description 2
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- -1 polysiloxane Polymers 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims 2
- 239000004599 antimicrobial Substances 0.000 claims 1
- 229940008099 dimethicone Drugs 0.000 claims 1
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 abstract description 3
- 208000015181 infectious disease Diseases 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000005855 radiation Effects 0.000 abstract description 3
- 238000012360 testing method Methods 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000002834 transmittance Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 239000000806 elastomer Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000218628 Ginkgo Species 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
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- 206010028980 Neoplasm Diseases 0.000 description 1
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- HIHIPCDUFKZOSL-UHFFFAOYSA-N ethenyl(methyl)silicon Chemical compound C[Si]C=C HIHIPCDUFKZOSL-UHFFFAOYSA-N 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000006386 memory function Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 229940083037 simethicone Drugs 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
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- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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- C08J2383/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon only; Derivatives of such polymers
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- C08J2483/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon only; Derivatives of such polymers
- C08J2483/04—Polysiloxanes
- C08J2483/05—Polysiloxanes containing silicon bound to hydrogen
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- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
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- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
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Abstract
The application discloses a positioning film, a preparation method and application thereof, wherein the positioning film comprises a component A and a component B, and the component A comprises the following raw materials in parts by mass: 80% or more of vinyl silicone oil, 0.1-10% of antibacterial agent, 1-10% of release agent, 0.1-1% of catalyst and less than 2% of modifier; the component B comprises the following raw materials in parts by mass: 80% or more vinyl silicone oil, 2-20% hydrogen silicone oil and 1-10% release agent. The positioning film is prepared from vinyl silicone oil and hydrogen-containing silicone oil, and has high transparency; the self-adhesion property is strong; the biocompatibility is good, the skin-sticking force is strong, and the skin-sticking agent can be in seamless fit with any part of a human body; has obvious blocking effect on the radiation of the radiotherapy laser of the patient, can specifically position the irradiation position and has accurate positioning. In addition, the positioning film is simple and easy to use, is economical in price and simple in production process, and can be prepared into disposable products, so that the risk of cross use infection is effectively avoided.
Description
Technical Field
The application relates to the technical field of radioactive tissue for radiotherapy, in particular to a positioning film, a preparation method and application.
Background
The utility model provides a radiotherapy locating film is a novel functional medical consumable with memory function, extensively is used for radiotherapy tumour patient's assistance-localization real-time and fixed, makes radiotherapy put, reset, and is fixed firm, reduces patient's position and removes the unnecessary damage to normal tissue that produces, improves the absorption of local focus to the ray. At present, a common radiotherapy positioning film is made of a high-molecular polymer low-temperature thermoplastic plate, and in the actual use process, the problems of low skin fitting degree, poor positioning precision, low biocompatibility, insufficient self-adhesion and the like of a patient exist.
Disclosure of Invention
In order to solve the problems existing in the prior radiotherapy positioning film in use, the application provides a positioning film, a preparation method and application.
In a first aspect, the application provides a positioning film, wherein the component A comprises the following raw materials in parts by mass: 80% or more of vinyl silicone oil, 0.1-10% of antibacterial agent, 1-10% of release agent, 0.1-1% of catalyst and less than 2% of modifier;
the component B comprises the following raw materials in parts by mass: 80% or more vinyl silicone oil, 2-20% hydrogen silicone oil and 1-10% release agent.
In a second aspect, the present application also provides a method for preparing the positioning film, which includes the following steps: the raw materials with the following mass ratios are obtained: more than 80 percent of vinyl silicone oil, 0.1 to 10 percent of antibacterial agent, 1 to 10 percent of release agent, 0.1 to 1 percent of catalyst and less than 2 percent of modifier are fully stirred and dissolved and are placed in a reaction kettle, and are heated to 65 to 75 ℃ to obtain a first reaction liquid;
the raw materials with the following mass ratios are obtained: mixing vinyl silicone oil with the concentration of more than 80%, hydrogen-containing silicone oil with the concentration of 2-20% and a release agent with the concentration of 1-10%, fully stirring and dissolving the raw materials, adding the raw materials into a first reaction liquid, mixing at normal temperature, and standing or vacuum defoaming to obtain a film prefabricating liquid;
and paving the obtained film prefabrication liquid in a grinding tool, standing until the film prefabrication liquid is clear, heating the film prefabrication liquid to 80-150 ℃ and attaching a film, and tailoring the film to required specifications to obtain a target product.
In a third aspect, the application also provides an application of the positioning film in a radiotherapy positioning film.
The application provides a positioning film, a preparation method and application, wherein the positioning film prepared from medical vinyl silicone oil has high transparency; the self-adhesion property is strong; the biocompatibility is good, the skin-sticking force is strong, and the skin-sticking agent can be in seamless fit with any part of a human body; has obvious blocking effect on the radiation of the radiotherapy laser of the patient, can specifically position the irradiation position and has accurate positioning. In addition, the positioning film is simple and easy to use, is economical in price and simple in production process, and can be prepared into disposable products, so that the risk of cross use infection is effectively avoided.
Detailed Description
Embodiments of the present application will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only for illustrating the present application and should not be construed as limiting the scope of the present application. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.
It should be noted that: in the present application, all embodiments and preferred methods of implementation mentioned herein may be combined with each other to form new solutions, unless otherwise specified. In the present application, all technical features mentioned herein and preferred features may be combined with each other to form new technical solutions, unless otherwise specified. In the present application, the percentage (%) or parts refer to weight percentage or parts by weight relative to the composition unless otherwise specified. In the present application, the components or preferred components thereof may be combined with each other to form a new technical solution, unless otherwise specified. In the present application, unless otherwise indicated, the numerical ranges "a-b" represent shorthand representations of any combination of real numbers between a and b, where a and b are both real numbers. For example, the numerical range "6-22" means that all real numbers between "6-22" have been listed throughout, and "6-22" is only a shorthand representation of a combination of these values. The "range" disclosed herein may take the form of a lower limit and an upper limit, which may be one or more lower limits and one or more upper limits, respectively. In the present application, each reaction or operation step may be performed sequentially or sequentially unless otherwise indicated. Preferably, the reaction processes herein are performed sequentially.
Unless otherwise defined, the technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. In addition, any method or material similar or equivalent to those described may be used in the present application.
In a first aspect, the application provides a positioning film, which comprises an A component and a B component, wherein the A component comprises the following raw materials in parts by mass: 80% or more of vinyl silicone oil, 0.1-10% of antibacterial agent, 1-10% of release agent, 0.1-1% of catalyst and less than 2% of modifier; the component B comprises the following raw materials in parts by mass: 80% or more vinyl silicone oil, 2-20% hydrogen silicone oil and 1-10% release agent.
In some embodiments of the present application, the positioning film includes an a component and a B component, where the a component includes the following raw materials in mass ratio: 94% of vinyl silicone oil, 1.5% of antibacterial agent, 3.5% of release agent, 0.2% of catalyst and 0.8% of modifier; the component B comprises the following raw materials in parts by mass: 92% of vinyl silicone oil, 6% of hydrogen silicone oil and 2% of release agent.
In some embodiments of the application, the release agent comprises simethicone.
In some embodiments of the application, the antibacterial agent comprises any one or a combination of two of plant extracts or chitosan, wherein the plant extracts refer to active ingredients for antibacterial and bacteriostatic action in plants.
In some embodiments of the application, the modifier is formed by mixing a maleic acid grafting agent, nano titanium dioxide, methyl vinyl silicone resin and hydroxy polysiloxane.
The catalyst is chloroplatinic acid-divinyl tetramethyl disiloxane complex.
In a second aspect, the present application also provides a method for preparing a positioning film, comprising the steps of:
the raw materials with the following mass ratios are obtained: more than 80 percent of vinyl silicone oil, 0.1 to 10 percent of antibacterial agent, 1 to 10 percent of release agent, 0.1 to 1 percent of catalyst and less than 2 percent of modifier are fully stirred and dissolved and are placed in a reaction kettle, and are heated to 65 to 75 ℃ to obtain a first reaction liquid;
the raw materials with the following mass ratios are obtained: mixing vinyl silicone oil with the concentration of more than 80%, hydrogen-containing silicone oil with the concentration of 2-20% and a release agent with the concentration of 1-10%, fully stirring and dissolving the raw materials, adding the raw materials into a first reaction liquid, mixing at normal temperature, and standing or vacuum defoaming to obtain a film prefabricating liquid;
and paving the obtained film prefabrication liquid in a grinding tool, standing until the film prefabrication liquid is clear, heating the film prefabrication liquid to 80-150 ℃ and attaching a film, and tailoring the film to required specifications to obtain a target product.
In a third aspect, the application also provides the use of a positioning film in a medical dressing.
The present application will be described in further detail with reference to examples.
Example 1
The embodiment is a positioning film, which comprises a component A and a component B, wherein the component A comprises the following raw materials in parts by mass: 85% of vinyl silicone oil, 5.5% of antibacterial agent, 8.5% of release agent, 0.2% of catalyst and 0.8% of modifier;
the component B comprises the following raw materials in parts by mass: 82% of vinyl silicone oil, 13% of hydrogen silicone oil and 5% of release agent.
The preparation process of the positioning film in this embodiment is as follows:
the raw materials with the following mass ratios are obtained: 85% of vinyl silicone oil, 5.5% of antibacterial agent, 8.5% of release agent, 0.2% of catalyst and 0.8% of modifier, and fully stirring and dissolving the raw materials, placing the raw materials in a reaction kettle, and heating to 67 ℃ to obtain a first reaction liquid;
the raw materials with the following mass ratios are obtained: the preparation method comprises the steps of (1) fully stirring and dissolving above 82% of vinyl silicone oil, 13% of hydrogen-containing silicone oil and 5% of release agent, adding the above raw materials into a first reaction liquid, mixing at normal temperature, and standing or vacuum defoaming to obtain a film prefabricated liquid;
and paving the obtained film prefabrication liquid in a grinding tool, standing until the film prefabrication liquid is clear, heating the film prefabrication liquid to 85 ℃, attaching a film, and tailoring the film to required specifications to obtain a target product.
Example 2
The embodiment is a positioning film, which comprises a component A and a component B, wherein the component A comprises the following raw materials in parts by mass: 98% of vinyl silicone oil, 0.4% of antibacterial agent, 1.2% of release agent, 0.3% of catalyst and 0.1% of modifier;
the component B comprises the following raw materials in parts by mass: 93.2% of vinyl silicone oil, 2.1% of hydrogen silicone oil and 4.7% of release agent.
The preparation process of the positioning film in this embodiment is as follows:
the raw materials with the following mass ratios are obtained: 98% of vinyl silicone oil, 0.4% of antibacterial agent, 1.2% of release agent, 0.3% of catalyst and 0.1% of modifier, and fully stirring and dissolving the raw materials, placing the raw materials in a reaction kettle, and heating the raw materials to 70 ℃ to obtain a first reaction liquid;
the raw materials with the following mass ratios are obtained: 93.2% of vinyl silicone oil, 2.1% of hydrogen-containing silicone oil and 4.7% of release agent, fully stirring and dissolving the raw materials, adding the raw materials into a first reaction liquid, mixing at normal temperature, and standing or vacuum defoaming to obtain a film prefabricating liquid;
and paving the obtained film prefabrication liquid in a grinding tool, standing until the film prefabrication liquid is clear, heating the film prefabrication liquid to 100 ℃, attaching a film, and tailoring the film to required specifications to obtain a target product.
Example 3
The embodiment is a positioning film, which comprises a component A and a component B, wherein the component A comprises the following raw materials in parts by mass: 90.3% of vinyl silicone oil, 4.5% of antibacterial agent, 3% of release agent, 0.4% of catalyst and 1.8% of modifier;
the component B comprises the following raw materials in parts by mass: 90.8% of vinyl silicone oil, 9% of hydrogen silicone oil and 1.2% of release agent.
The preparation process of the positioning film in this embodiment is as follows:
the raw materials with the following mass ratios are obtained: 90.3% vinyl silicone oil, 4.5% antibacterial agent, 3% release agent, 0.4% catalyst and modifier less than 1.8%, stirring and dissolving the above materials, placing in a reaction kettle, and heating to 73 ℃ to obtain a first reaction solution;
the raw materials with the following mass ratios are obtained: 90.8% or more of vinyl silicone oil, 9% of hydrogen-containing silicone oil and 1.2% of release agent, fully stirring and dissolving the raw materials, adding the raw materials into a first reaction liquid, mixing at normal temperature, and standing or vacuum defoaming to obtain a film prefabricating liquid;
and paving the obtained film prefabrication liquid in a grinding tool, standing until the film prefabrication liquid is clear, heating the film prefabrication liquid to 130 ℃, attaching a film, and cutting the film to required specifications to obtain a target product.
Comparative example
The existing positioning film comprises the following components in percentage by mass: 40-50 parts of elastomer or elastomer (TPE), 37-47 parts of solvent, 0.8-2.5 parts of catalyst and 5-10 parts of additive, wherein the solvent is selected from any one or more than two of petroleum ether, butyl acetate and ethyl acetate; the catalyst is selected from hydrochloric acid or acetic acid; the additive comprises tackifying resin, antioxidant and lubricant according to the weight ratio of 1:1:1, wherein the tackifying resin is rosin ester; the antioxidant is semen Ginkgo extract with mass fraction of 20%.
Test sample preparation: the positioning films prepared in examples 1 to 3 and comparative examples were subjected to the following test:
1. transmittance: the vacuum oven dries the solvent and tests the light transmittance through the ultraviolet spectrophotometer;
2. density: the detection method adopts a conventional detection method;
3. hardness: testing with a Shore A durometer;
4. biocompatibility: the detection method adopts a conventional detection method.
The performance of the positioning films prepared in examples 1 to 3 was tested, and the measured technical indexes are shown in the following table 1.
TABLE 1
Detecting items | Example 1 | Example 2 | Example 3 | Comparative example |
Transmittance% | 92.3 | 93.3 | 90.3 | 55.7 |
Density g/cm 3 | 0.97 | 1.03 | 0.99 | 0.81 |
Shore A hardness | 32 | 38 | 35 | 45 |
Biocompatibility of | Excellent (excellent) | Excellent (excellent) | Excellent (excellent) | In general |
In conclusion, as can be seen from the test results of examples 1-3 and comparative examples, the light transmittance of the positioning film of the present application is high and can reach 92% or more; the density is about 1.0, and is more similar to the density of a human body; the hardness is low, and the softness is good; the holding viscosity is high, and the bonding strength is high; better biocompatibility and good skin fit.
The application provides a positioning film, a preparation method and application thereof, wherein the positioning film prepared from vinyl silicone oil and hydrogen-containing silicone oil has high transparency; the self-adhesion property is strong; the biocompatibility is good, the skin-sticking force is strong, and the skin-sticking agent can be in seamless fit with any part of a human body; has obvious blocking effect on the radiation of the radiotherapy laser of the patient, can specifically position the irradiation position and has accurate positioning. In addition, the positioning film is simple and easy to use, is economical in price and simple in production process, and can be prepared into disposable products, so that the risk of cross use infection is effectively avoided.
The foregoing is illustrative of the best mode of carrying out the application, and is not presented in any detail as is known to those of ordinary skill in the art. The protection scope of the application is defined by the claims, and any equivalent transformation based on the technical teaching of the application is also within the protection scope of the application.
Claims (7)
1. The positioning film is characterized by comprising a component A and a component B, wherein the component A comprises the following raw materials in parts by mass: 80% or more of vinyl silicone oil, 0.1-10% of antibacterial agent, 1-10% of release agent, 0.1-1% of catalyst and less than 2% of modifier;
the component B comprises the following raw materials in parts by mass: 80% or more vinyl silicone oil, 2-20% hydrogen silicone oil and 1-10% release agent.
2. The positioning film according to claim 1, wherein the positioning film comprises an A component and a B component, and the A component comprises the following raw materials in parts by mass: 94% of vinyl silicone oil, 1.5% of antibacterial agent, 3.5% of release agent, 0.2% of catalyst and 0.8% of modifier;
the component B comprises the following raw materials in parts by mass: 92% of vinyl silicone oil, 6% of hydrogen silicone oil and 2% of release agent.
3. The positioning film of claim 1 wherein the release agent comprises dimethicone.
4. The positioning film of claim 1 wherein the antimicrobial agent comprises either one or a combination of both of a plant extract or chitosan.
5. The positioning film according to claim 1, wherein the modifier is formed by mixing a maleic acid grafting agent, nano titanium dioxide and hydroxy polysiloxane;
the catalyst is chloroplatinic acid-divinyl tetramethyl disiloxane complex.
6. A method of producing the positioning film according to any one of claims 1 to 5, comprising the steps of:
the raw materials with the following mass ratios are obtained: more than 80 percent of vinyl silicone oil, 0.1 to 10 percent of antibacterial agent, 1 to 10 percent of release agent, 0.1 to 1 percent of catalyst and less than 2 percent of modifier are fully stirred and dissolved and are placed in a reaction kettle, and are heated to 65 to 75 ℃ to obtain a first reaction liquid;
the raw materials with the following mass ratios are obtained: mixing vinyl silicone oil with the concentration of more than 80%, hydrogen-containing silicone oil with the concentration of 2-20% and a release agent with the concentration of 1-10%, fully stirring and dissolving the raw materials, adding the raw materials into a first reaction liquid, mixing at normal temperature, and standing or vacuum defoaming to obtain a film prefabricating liquid;
and paving the obtained film prefabrication liquid in a grinding tool, standing until the film prefabrication liquid is clear, heating the film prefabrication liquid to 80-150 ℃ and attaching a film, and tailoring the film to required specifications to obtain a target product.
7. Use of a positioning membrane according to any one of claims 1-5 in a radiotherapy positioning membrane.
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