CN116899122B - Tumor tissue fluorescence labeling method and system - Google Patents
Tumor tissue fluorescence labeling method and system Download PDFInfo
- Publication number
- CN116899122B CN116899122B CN202310807560.7A CN202310807560A CN116899122B CN 116899122 B CN116899122 B CN 116899122B CN 202310807560 A CN202310807560 A CN 202310807560A CN 116899122 B CN116899122 B CN 116899122B
- Authority
- CN
- China
- Prior art keywords
- tube
- tumor tissue
- injection
- rotating ring
- positioning
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 73
- 239000007850 fluorescent dye Substances 0.000 title claims abstract description 30
- 238000001215 fluorescent labelling Methods 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title claims abstract description 16
- 238000002347 injection Methods 0.000 claims abstract description 95
- 239000007924 injection Substances 0.000 claims abstract description 95
- 238000003756 stirring Methods 0.000 claims abstract description 46
- 239000007788 liquid Substances 0.000 claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 15
- 230000005540 biological transmission Effects 0.000 claims description 37
- 230000001681 protective effect Effects 0.000 claims description 24
- 238000009434 installation Methods 0.000 claims description 16
- 230000005855 radiation Effects 0.000 claims description 9
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 claims description 6
- 230000035755 proliferation Effects 0.000 claims description 3
- 238000007689 inspection Methods 0.000 claims description 2
- 239000003550 marker Substances 0.000 description 20
- 238000002372 labelling Methods 0.000 description 12
- 230000017525 heat dissipation Effects 0.000 description 10
- 239000000463 material Substances 0.000 description 5
- 239000000428 dust Substances 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 229920001661 Chitosan Polymers 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 206010027476 Metastases Diseases 0.000 description 2
- 230000004807 localization Effects 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3904—Markers, e.g. radio-opaque or breast lesions markers specially adapted for marking specified tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Radiology & Medical Imaging (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention relates to the technical field of tumor positioning, in particular to a tumor tissue fluorescence labeling method and a tumor tissue fluorescence labeling system; including location mark pipe and injection mechanism, injection mechanism includes syringe and hybrid bottle, the syringe includes the injection tube, the syringe needle, the piston board, the threaded rod, the battery, drive assembly and drive gear, hybrid bottle includes bottle and stirring subassembly, add location mark pipe and mixed liquid to hybrid bottle's inside through adding the mouth, and start stirring subassembly, mix location mark pipe and mixed liquid, through CT machine cooperation, insert the syringe needle in the tumour tissue, start drive assembly, cooperate through drive gear, swivel becket and threaded rod, drive the piston board and slide to the direction of syringe needle, thereby carry the mixture that contains location mark pipe to the tumour tissue in, adopt above-mentioned structure, when the injection location mark pipe, degree of automation is higher, and is more convenient for operation.
Description
Technical Field
The invention relates to the technical field of tumor positioning, in particular to a tumor tissue fluorescence labeling method and a tumor tissue fluorescence labeling system.
Background
The tumor is rapidly and timely positioned, the marker is firmly attached in the tumor and does not shift, the problem of tumor mobility is solved, the technical problem of the medical field is always solved, the dynamic tracking is carried out on the marker, and then the tumor is immediately positioned, so that the radiotherapy equipment can more accurately position the tumor, the damage to the healthy tissues of a human body is reduced, and the technical effect which is needed to be achieved in clinic is urgent.
Therefore, the prior published patent (CN 209790636U) proposes a tumor positioning marking device, which is characterized by comprising a positioning marking tube, wherein the positioning marking tube is a two-end closed type reticular tube consisting of a tube body and a tube cap, the grids of the reticular tube are of hexagonal structures, fluorescent markers are coated on the surfaces of the grids forming the positioning marking tube, the length L of the positioning marking tube is 20-40 nm, the diameter D of the tube body of the positioning marking tube is 10-20 nm, the positioning marking tube is made of a carbon nano-chitosan degradable material, and the fluorescent markers are fluorescein isothiocyanate. The device has smaller volume, can be injected into tumor tissues along with injection liquid by an injection device, and is convenient to operate; the device is degradable and does not need to be taken out by operation; the device can not only carry out positioning mark on the tumor tissue body, but also carry out positioning mark on the auxiliary tumor tissue formed by metastasis.
However, in the practical application process, the existing tumor positioning and marking device is injected into tumor tissues through a common injector, the structure of the conventional injector is simple, the manual operation of medical staff is needed, the automation degree is low, and the operation is troublesome.
Disclosure of Invention
The invention aims to provide a tumor tissue fluorescence labeling method and system, which solve the problems that in the prior art, in the practical application process, a tumor positioning and labeling device is injected into tumor tissue through a common injector, the structure of the conventional injector is simpler, the manual operation of medical staff is required, the degree of automation is lower, and the operation is more troublesome.
In order to achieve the above purpose, the invention provides a tumor tissue fluorescence labeling system, which comprises a positioning labeling tube and an injection mechanism, wherein the positioning labeling tube is a two-end closed net-shaped tube consisting of a tube body and a tube cap, the net of the positioning labeling tube is of a hexagonal structure, and fluorescent markers are coated on the surface of the net of the positioning labeling tube;
the injection mechanism comprises an injector and a mixing bottle, the injector comprises an injection cylinder, an injection needle, a piston plate, a threaded rod, a storage battery, a driving assembly and a driving gear, the mixing bottle comprises a bottle body and a stirring assembly, one end of the injection cylinder is provided with the injection needle, the other end of the injection cylinder is rotationally connected with a rotating ring, the inside of the rotating ring is provided with a threaded connection with the threaded rod, the piston plate is close to one surface of the rotating ring, the threaded rod is located one end of the inside of the injection cylinder is inserted into the inside of the bearing seat, the piston plate slides in the inside of the injection cylinder, one end of the injection cylinder, which is far away from the injection needle, is provided with the storage battery and the driving assembly, the storage battery is electrically connected with the driving assembly, the outside of the rotating ring is provided with the driving gear, the output end of the driving assembly is mechanically driven with the driving gear, the top of the bottle is provided with an adding port, and the mixing assembly is further arranged on the mixing bottle, and the stirring assembly is used for stirring the inside of the marking body and the mixing bottle.
The driving assembly comprises a servo motor, an output shaft and an output gear, wherein the servo motor is arranged at one end of the injection cylinder, which is far away from the injection needle, the output end of the servo motor is provided with the output shaft, one end of the output shaft, which is far away from the servo motor, is provided with the output gear, and the output gear is meshed with the transmission gear.
The transmission gear comprises a gear body and two installation wing rings, the gear body is sleeved outside the rotating ring, the installation wing rings are arranged on two sides of the gear body, and the installation wing rings are detachably connected with the outer side walls of the rotating ring.
The stirring assembly comprises a support, a driving motor, a stirring shaft and stirring blades, wherein the support is installed at the top of the bottle body, the driving motor is arranged on the support, the stirring shaft is arranged at the output end of the driving motor, and the stirring blades are arranged at one end of the stirring shaft, which is located in the bottle body.
The tumor tissue fluorescent marking system further comprises a protective shell, one end, far away from the injection needle, of the injection cylinder is provided with the protective shell, and the protective shell is covered on the outer portion of the driving assembly and the transmission gear.
The protective housing includes casing and installation pterygoid lamina, the casing cover is established drive assembly with drive gear's outside, the casing is close to the one end of injection tube is provided with the installation pterygoid lamina, the installation pterygoid lamina with the injection tube is dismantled and is connected.
The invention also provides a tumor tissue fluorescence labeling method which is applied to the tumor tissue fluorescence labeling system and comprises the following steps:
the positioning mark pipe and the mixed liquid are added into the mixing bottle through the adding port, the stirring assembly is started, and the positioning mark pipe and the mixed liquid are uniformly mixed;
the driving assembly is started, the rotating ring is driven to rotate on the injection cylinder through the transmission gear, so that the threaded rod is screwed in the rotating ring, the piston is driven to move towards the direction of the injection needle, and air in the injection cylinder is exhausted;
inserting the injection needle into the mixing bottle, starting the driving assembly, and driving the piston plate to slide towards the rotating ring through the matching of the transmission gear, the rotating ring and the threaded rod, so as to convey the mixture containing the positioning mark tube into the injection cylinder;
the injection needle is inserted into tumor tissues through the matching of a CT machine, the driving assembly is started, and the piston plate is driven to slide towards the injection needle through the matching of the transmission gear, the rotating ring and the threaded rod, so that the mixture containing the positioning mark tube is conveyed into the tumor tissues;
the tumor tissue injected with the positioning mark tube absorbs the fluorescent mark coated on the surface of the positioning mark tube, namely fluorescein isothiocyanate, during proliferation, marks the tumor tissue by using a fluorescent mark method, and performs positioning by matching with fluorescent development generated during CT machine radiation inspection.
According to the tumor tissue fluorescence labeling method and system, the positioning labeling tube and the mixed liquid are added into the mixing bottle through the adding port, the stirring assembly is started, the positioning labeling tube and the mixed liquid are uniformly mixed, the injection needle is inserted into the mixing bottle, the driving assembly is started, the piston plate is driven to slide in the direction of the rotating ring through the matching of the transmission gear, the rotating ring and the threaded rod, so that the mixture containing the positioning labeling tube is conveyed into the injection cylinder, the injection needle is inserted into tumor tissue through the matching of the CT machine, the driving assembly is started, the piston plate is driven to slide in the direction of the injection needle through the matching of the transmission gear, the rotating ring and the threaded rod, and therefore the mixture containing the positioning labeling tube is conveyed into tumor tissue.
Drawings
In order to more clearly illustrate the embodiments of the invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic view of a syringe and a mixing bottle according to a first embodiment of the present invention.
Fig. 2 is a schematic view of the structure of a syringe according to the first embodiment of the present invention.
Fig. 3 is an enlarged view of a partial structure at a of fig. 2 provided by the present invention.
Fig. 4 is a schematic view showing the internal structure of a syringe according to the first embodiment of the present invention.
Fig. 5 is a schematic view showing the structure of a stirring assembly in the first embodiment of the present invention.
Fig. 6 is a schematic view of the structure of the positioning marker tube in the first embodiment of the present invention.
Fig. 7 is a schematic view of a syringe according to a second embodiment of the present invention.
Fig. 8 is a schematic view of a syringe according to a third embodiment of the present invention.
Fig. 9 is an enlarged view of a partial structure at B of fig. 8 provided by the present invention.
FIG. 10 is a flow chart of the steps of the fluorescence labeling method for tumor tissue provided by the invention.
101-positioning marking tube, 102-syringe, 103-mixing bottle, 104-syringe barrel, 105-syringe needle, 106-piston plate, 107-threaded rod, 108-battery, 109-drive assembly, 110-transmission gear, 111-bottle body, 112-stirring assembly, 113-servo motor, 114-output shaft, 115-output gear, 116-gear body, 117-mounting wing ring, 118-bracket, 119-driving motor, 120-stirring shaft, 121-stirring blade, 122-tube body, 123-cap, 124-rotating ring, 125-bearing seat, 126-adding port, 201-protective shell, 202-shell, 203-mounting wing plate, 301-heat dissipation plate, 302-heat dissipation groove, 303-placing groove and 304-filter screen.
Detailed Description
Embodiments of the present invention are described in detail below, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the drawings are illustrative and intended to explain the present invention and should not be construed as limiting the invention.
First embodiment:
referring to fig. 1 to 6, fig. 1 is a schematic structural view of a syringe and a mixing bottle according to a first embodiment, fig. 2 is a schematic structural view of the syringe according to the first embodiment, fig. 3 is a partial enlarged structural view of a portion a of fig. 2, fig. 4 is a schematic structural view of an inner portion of a syringe according to the first embodiment, fig. 5 is a schematic structural view of a stirring assembly according to the first embodiment, and fig. 6 is a schematic structural view of a positioning mark tube according to the first embodiment.
The invention provides a tumor tissue fluorescence labeling system, which comprises a positioning labeling tube 101 and an injection mechanism, wherein the injection mechanism comprises an injector 102 and a mixing bottle 103, the injector 102 comprises an injection cylinder 104, an injection needle 105, a piston plate 106, a threaded rod 107, a storage battery 108, a driving assembly 109 and a transmission gear 110, the mixing bottle 103 comprises a bottle body 111 and a stirring assembly 112, the driving assembly 109 comprises a servo motor 113, an output shaft 114 and an output gear 115, the transmission gear 110 comprises a gear body 116 and two mounting wing rings 117, and the stirring assembly 112 comprises a bracket 118, a driving motor 119, a stirring shaft 120 and stirring blades 121.
For the specific embodiment, the positioning mark tube 101 is a two-end closed net-shaped tube composed of a tube body 122 and a tube cap 123, the grid of the positioning mark tube 101 is of a hexagonal structure, the surface of the grid of the positioning mark tube 101 is coated with a fluorescent marker, the positioning mark tube 101 is made of a carbon nano-chitosan degradable material, the fluorescent marker is fluorescein isothiocyanate, and the marker is degradable and does not need to be taken out by an operation; the marker not only can be used for positioning and marking tumor tissue bodies, but also can be used for positioning and marking auxiliary tumor tissues formed by metastasis.
Wherein one end of the injection tube 104 is provided with the injection needle 105, the other end of the injection tube 104 is rotatably connected with a rotating ring 124, the inside of the rotating ring 124 is provided with a threaded rod 107 in a threaded connection manner, one surface of the piston plate 106, which is close to the rotating ring 124, is provided with a bearing seat 125, one end of the threaded rod 107, which is positioned in the inside of the injection tube 104, is inserted into the bearing seat 125, the piston plate 106 slides in the inside of the injection tube 104, one end of the injection tube 104, which is far away from the injection needle 105, is provided with a storage battery 108 and a driving assembly 109, the storage battery 108 is electrically connected with the driving assembly 109, the outside of the rotating ring 124 is provided with a transmission gear 110, the output end of the driving assembly 109 is mechanically driven with the transmission gear 110, the top end of the bottle 111 is provided with an adding port 126, the mixing bottle 103 is further provided with the stirring assembly 112, the stirring assembly 112 is used for stirring the positioning mark tube 101 and the mixed liquid in the bottle body 111, the positioning mark tube 101 and the mixed liquid are added into the mixing bottle 103 through the adding port 126, the stirring assembly 112 is started, the positioning mark tube 101 and the mixed liquid are uniformly mixed, the injection needle 105 is inserted into the mixing bottle 103, the driving assembly 109 is started, the piston plate 106 is driven to slide towards the direction of the rotating ring 124 through the matching of the transmission gear 110, the rotating ring 124 and the threaded rod 107, the mixture containing the positioning mark tube 101 is conveyed into the injection cylinder 104, the injection needle 105 is inserted into tumor tissue through the matching of a CT machine, the driving assembly 109 is started, through the cooperation of the transmission gear 110, the rotating ring 124 and the threaded rod 107, the piston plate 106 is driven to slide towards the direction of the injection needle 105, so that the mixture containing the positioning mark tube 101 is conveyed into tumor tissues.
Secondly, the servo motor 113 is mounted at one end of the syringe 104 far away from the syringe needle 105, an output end of the servo motor 113 is provided with an output shaft 114, one end of the output shaft 114 far away from the servo motor 113 is provided with an output gear 115, the output gear 115 is meshed with the transmission gear 110, the servo motor 113 is started, the output gear 115 is driven to rotate by the output shaft 114, and the output gear 115 is meshed with the transmission gear 110, so that the rotating ring 124 is driven to rotate on the syringe 104.
Meanwhile, the gear body 116 is sleeved outside the rotating ring 124, the mounting wing rings 117 are arranged on two sides of the gear body 116, the mounting wing rings 117 are detachably connected with the outer side wall of the rotating ring 124, the gear body 116 is sleeved outside the rotating ring 124, and the mounting wing rings 117 are fixed on the outer side wall of the rotating ring 124 by using screws, so that the mounting of the rotating ring 124 is completed.
In addition, the support 118 is mounted at the top of the bottle 111, the support 118 is provided with the driving motor 119, the output end of the driving motor 119 is provided with the stirring shaft 120, one end of the stirring shaft 120, which is located in the bottle 111, is provided with the stirring blade 121, the driving motor 119 is started, and the stirring blade 121 is driven to rotate by the stirring shaft 120, so that the positioning marking pipe 101 and the mixed liquid are mixed by the rotating stirring blade 121.
When the tumor tissue fluorescence labeling system of the embodiment is used, the positioning labeling tube 101 is made of a carbon nano-chitosan degradable material, and the fluorescence labeling material is fluorescein isothiocyanate, so that the labeling material can be degraded and does not need to be taken out in an operation; the marker not only can position and mark the tumor tissue body, but also can position and mark the auxiliary tumor tissue formed by transfer, the positioning marking tube 101 and the mixed liquid are added into the mixed bottle 103 through the adding port 126, the stirring assembly 112 is started, the positioning marking tube 101 and the mixed liquid are uniformly mixed, the injection needle 105 is inserted into the mixed bottle 103, the driving assembly 109 is started, the piston plate 106 is driven to slide towards the direction of the rotating ring 124 through the matching of the transmission gear 110, the rotating ring 124 and the threaded rod 107, so that the mixture containing the positioning marking tube 101 is conveyed into the injection tube 104, the injection needle 105 is inserted into the tumor tissue through the matching of a CT machine, the driving assembly 109 is started, the piston plate 106 is driven to slide towards the direction of the injection needle 105 through the matching of the transmission gear 110, the rotating ring 124 and the threaded rod 107, and the mixture containing the positioning marking tube 101 is conveyed into the tumor tissue automatically, and the positioning marking operation is more convenient when the injection tube 101 is used.
Second embodiment:
on the basis of the first embodiment, please refer to fig. 7, fig. 7 is a schematic diagram of the structure of the syringe in the second embodiment.
The invention provides a tumor tissue fluorescence labeling system which also comprises a protective shell 201, wherein the protective shell 201 comprises a shell 202 and a mounting wing plate 203.
For this embodiment, the end of the syringe 104 away from the injection needle 105 is provided with the protective housing 201, the protective housing 201 is covered on the outside of the driving assembly 109 and the transmission gear 110, and the driving assembly 109 and the transmission gear 110 are protected by using the protective housing 201, so as to avoid the influence of the external environment on the engagement position of the driving assembly 109 and the transmission gear 110.
Wherein, the casing 202 is covered outside the driving assembly 109 and the transmission gear 110, one end of the casing 202, which is close to the syringe 104, is provided with the installation wing plate 203, the installation wing plate 203 is detachably connected with the syringe 104, and after the casing 202 is covered outside the driving assembly 109 and the transmission gear 110, the installation wing plate 203 is fixed on the syringe 104 by using screws, thereby completing the installation of the protective shell 201.
When the tumor tissue fluorescence labeling system of the embodiment is used, after the casing 202 is covered outside the driving assembly 109 and the transmission gear 110, the mounting wing plate 203 is fixed on the injection cylinder 104 by using a screw, so that the mounting of the protective shell 201 is completed, the driving assembly 109 and the transmission gear 110 are protected by using the protective shell 201, and the influence of the external environment on the meshing position of the driving assembly 109 and the transmission gear 110 is avoided.
Third embodiment:
on the basis of the second embodiment, please refer to fig. 8 and 9, fig. 8 is a schematic structural view of the syringe in the third embodiment, and fig. 9 is a partial enlarged structural view at B of fig. 8.
The invention provides a tumor tissue fluorescence labeling system which also comprises a heat dissipation plate 301.
For this embodiment, the heat dissipation plate 301 is disposed on the side wall of the protective case 201, the heat dissipation plate 301 is provided with a heat dissipation groove 302, the heat dissipation groove 302 corresponds to the servo motor 113, and the inside of the protective case 201 is kept in circulation with the outside air through the arrangement of the heat dissipation groove 302, so that the heat generated during the operation of the servo motor 113 is taken away by the flowing air, and the heat dissipation of the servo motor 113 is performed.
Wherein, heating panel 301 extends to one side of the outside of protective housing 201 is provided with standing groove 303, standing groove 303 runs through the radiating groove 302, the inside of standing groove 303 is provided with filter screen 304, through the setting of filter screen 304 filters the dust in the air, avoids too much dust to pass through radiating groove 302 enters into the inside of protective housing 201, to the operation of servo motor 113 causes the influence.
When the tumor tissue fluorescence labeling system of the embodiment is used, the heat dissipation groove 302 is arranged, so that the inside of the protective shell 201 is kept in circulation with the outside air, heat generated during operation of the servo motor 113 is taken away through flowing air, the servo motor 113 is subjected to heat dissipation, dust in the air is filtered through the arrangement of the filter screen 304, and excessive dust is prevented from entering the inside of the protective shell 201 through the heat dissipation groove 302, so that the operation of the servo motor 113 is influenced.
Referring to fig. 10, the present invention further provides a tumor tissue fluorescence labeling method, which is applied to the tumor tissue fluorescence labeling system as described above, and comprises the following steps:
s1: adding the positioning mark pipe 101 and the mixed liquid into the mixing bottle 103 through the adding port 126, starting the stirring assembly 112, and uniformly mixing the positioning mark pipe 101 and the mixed liquid;
s2: starting the driving assembly 109, driving the rotating ring 124 to rotate on the injection cylinder 104 through the transmission gear 110, so that the threaded rod 107 is screwed in the rotating ring 124, thereby driving the piston to move towards the direction of the injection needle 105, and exhausting air in the injection cylinder 104;
s3: inserting the injection needle 105 into the mixing bottle 103, starting the driving assembly 109, and driving the piston plate 106 to slide towards the rotating ring 124 through the matching of the transmission gear 110, the rotating ring 124 and the threaded rod 107, so as to convey the mixture containing the positioning mark pipe 101 into the injection cylinder 104;
s4: inserting the injection needle 105 into tumor tissue through the cooperation of a CT machine, starting the driving assembly 109, and driving the piston plate 106 to slide towards the direction of the injection needle 105 through the cooperation of the transmission gear 110, the rotating ring 124 and the threaded rod 107 so as to convey the mixture containing the positioning mark tube 101 into the tumor tissue;
s5: the tumor tissue injected with the localization marker tube 101 absorbs the fluorescence marker coated on the surface of the localization marker tube 101, i.e., fluorescein isothiocyanate, during proliferation, and is labeled by fluorescence labeling method, and localized in cooperation with fluorescence development generated during CT machine radiation examination.
In this embodiment, the positioning marker tube 101 and the mixed liquid are added into the mixing bottle 103 through the adding port 126, the stirring assembly 112 is started, the positioning marker tube 101 and the mixed liquid are uniformly mixed, the driving assembly 109 is started, the driving gear 110 drives the rotating ring 124 to rotate on the injection cylinder 104, the threaded rod 107 is made to rotate in the rotating ring 124, the piston is driven to move towards the injection needle 105, air in the injection cylinder 104 is exhausted, the injection needle 105 is inserted into the mixing bottle 103, the driving assembly 109 is started, the piston plate 106 is driven to slide towards the rotating ring 124 through the matching of the driving gear 110, the rotating ring 124 and the threaded rod 107, the mixture containing the positioning marker tube 101 is conveyed into the injection cylinder 104, the injection needle 105 is inserted into tumor tissue through the matching of a CT machine, the driving assembly 109 is started, the driving gear 110 drives the piston to move towards the injection needle 105 towards the direction of the injection needle 105, the tumor tissue is conveyed into the tumor tissue through the matching of the CT machine, and the fluorescent marker 101 is conveyed towards the tumor tissue, and the fluorescent marker 101 is coated on the surface of the tumor tissue by the matching of the driving plate, and the fluorescent marker 101 is absorbed by the fluorescent marker during the fluorescent marker is conveyed to the fluorescent marker tube.
The above disclosure is only a preferred embodiment of the present invention, and it should be understood that the scope of the invention is not limited thereto, and those skilled in the art will appreciate that all or part of the procedures described above can be performed according to the equivalent changes of the claims, and still fall within the scope of the present invention.
Claims (6)
1. The tumor tissue fluorescent marking system comprises a positioning marking tube, wherein the positioning marking tube is a two-end closed net-shaped tube consisting of a tube body and a tube cap, the grid of the positioning marking tube is of a hexagonal structure, the surface of the grid of the positioning marking tube is coated with fluorescent markers,
the injection mechanism is also included;
the injection mechanism comprises an injector and a mixing bottle, the injector comprises an injection cylinder, an injection needle, a piston plate, a threaded rod, a storage battery, a driving assembly and a driving gear, the mixing bottle comprises a bottle body and a stirring assembly, one end of the injection cylinder is provided with the injection needle, the other end of the injection cylinder is rotationally connected with a rotating ring, the threaded rod is arranged in the rotating ring, the piston plate is provided with a bearing seat close to one surface of the rotating ring, one end of the threaded rod, which is positioned in the injection cylinder, is inserted into the bearing seat, the piston plate slides in the injection cylinder, one end, which is far away from the injection needle, of the injection cylinder is provided with the storage battery and the driving assembly, the storage battery is electrically connected with the driving assembly, the transmission gear is arranged outside the rotating ring, the output end of the driving assembly is mechanically driven with the transmission gear, an adding port is arranged at the top end of the bottle body, the stirring assembly is further arranged on the mixing bottle, and the stirring assembly is used for carrying out positioning and stirring on mixed liquid in the marking body.
The tumor tissue fluorescence labeling system further comprises a protective shell, wherein one end of the injection cylinder, which is far away from the injection needle, is provided with the protective shell, and the protective shell is covered outside the driving assembly and the transmission gear;
the tumor tissue fluorescence labeling system further comprises a heat radiation plate, the heat radiation plate is arranged on the side wall of the protective shell, a heat radiation groove is formed in the heat radiation plate and corresponds to the servo motor, one side of the heat radiation plate extending to the outside of the protective shell is provided with a placing groove, the placing groove penetrates through the heat radiation groove, and a filter screen is arranged in the placing groove.
2. The tumor tissue fluorescent labeling system as claimed in claim 1, wherein,
the driving assembly comprises a servo motor, an output shaft and an output gear, wherein the servo motor is arranged at one end, far away from the injection needle, of the injection cylinder, the output end of the servo motor is provided with the output shaft, one end, far away from the servo motor, of the output shaft is provided with the output gear, and the output gear is meshed with the transmission gear.
3. The tumor tissue fluorescent labeling system as claimed in claim 1, wherein,
the transmission gear comprises a gear body and two installation wing rings, the gear body is sleeved outside the rotating ring, the installation wing rings are arranged on two sides of the gear body, and the installation wing rings are detachably connected with the outer side walls of the rotating ring.
4. The tumor tissue fluorescence labeling system according to claim 3, wherein,
the stirring assembly comprises a support, a driving motor, a stirring shaft and stirring blades, wherein the support is installed at the top of the bottle body, the driving motor is arranged on the support, the stirring shaft is arranged at the output end of the driving motor, and the stirring blades are arranged at one end of the stirring shaft, which is positioned in the bottle body.
5. The tumor tissue fluorescent labeling system as claimed in claim 1, wherein,
the protective housing includes casing and installation pterygoid lamina, the casing cover is established drive assembly with drive gear's outside, the casing is close to the one end of injection tube is provided with the installation pterygoid lamina, the installation pterygoid lamina with the injection tube is dismantled and is connected.
6. A tumor tissue fluorescence labeling method applied to the tumor tissue fluorescence labeling system as claimed in claim 1, which is characterized by comprising the following steps:
the positioning mark pipe and the mixed liquid are added into the mixing bottle through the adding port, the stirring assembly is started, and the positioning mark pipe and the mixed liquid are uniformly mixed;
the driving assembly is started, the rotating ring is driven to rotate on the injection cylinder through the transmission gear, so that the threaded rod is screwed in the rotating ring, the piston is driven to move towards the direction of the injection needle, and air in the injection cylinder is exhausted;
inserting the injection needle into the mixing bottle, starting the driving assembly, and driving the piston plate to slide towards the rotating ring through the matching of the transmission gear, the rotating ring and the threaded rod, so as to convey the mixture containing the positioning mark tube into the injection cylinder;
the injection needle is inserted into tumor tissues through the matching of a CT machine, the driving assembly is started, and the piston plate is driven to slide towards the injection needle through the matching of the transmission gear, the rotating ring and the threaded rod, so that the mixture containing the positioning mark tube is conveyed into the tumor tissues;
the tumor tissue injected with the positioning mark tube absorbs the fluorescent mark coated on the surface of the positioning mark tube, namely fluorescein isothiocyanate, during proliferation, marks the tumor tissue by using a fluorescent mark method, and performs positioning by matching with fluorescent development generated during CT machine radiation inspection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310807560.7A CN116899122B (en) | 2023-07-03 | 2023-07-03 | Tumor tissue fluorescence labeling method and system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310807560.7A CN116899122B (en) | 2023-07-03 | 2023-07-03 | Tumor tissue fluorescence labeling method and system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116899122A CN116899122A (en) | 2023-10-20 |
| CN116899122B true CN116899122B (en) | 2024-04-09 |
Family
ID=88366003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310807560.7A Active CN116899122B (en) | 2023-07-03 | 2023-07-03 | Tumor tissue fluorescence labeling method and system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116899122B (en) |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101524501B1 (en) * | 2013-11-25 | 2015-06-01 | 김동주 | Controlling apparatus of syringe for needle biopsy |
| CN204379912U (en) * | 2013-11-20 | 2015-06-10 | 杨春梅 | Oncology microinjection apparatus |
| CN108393210A (en) * | 2018-03-30 | 2018-08-14 | 宁波高新区新柯保汽车科技有限公司 | A kind of auto parts machinery paint spraying apparatus |
| CN208355916U (en) * | 2017-07-17 | 2019-01-11 | 贾庆哲 | Cardio angiographic unfolder |
| CN209790636U (en) * | 2018-09-07 | 2019-12-17 | 云南省肿瘤医院 | Tumor positioning and marking device |
| CN211751534U (en) * | 2019-04-16 | 2020-10-27 | 任林 | Department of neurology doctor uses autoinjector |
| CN213251247U (en) * | 2020-06-12 | 2021-05-25 | 东营市人民医院 | Dispensing device for oncology nursing |
| CN113521449A (en) * | 2021-08-09 | 2021-10-22 | 山东第一医科大学附属肿瘤医院(山东省肿瘤防治研究院、山东省肿瘤医院) | Thermostatic inhibitor injection equipment for tumor immunotherapy and implementation method thereof |
| CN214969109U (en) * | 2021-02-03 | 2021-12-03 | 福建省漳州市医院 | Proportioning machine for medical infusion |
| CN217566785U (en) * | 2021-05-24 | 2022-10-14 | 北京思瑞医疗诊所有限公司 | Acupuncture point injection device |
| CN217772579U (en) * | 2022-06-09 | 2022-11-11 | 唐彩霞 | Poultry animal doctor uses immunity injection device |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090217932A1 (en) * | 2008-03-03 | 2009-09-03 | Ethicon Endo-Surgery, Inc. | Intraluminal tissue markers |
-
2023
- 2023-07-03 CN CN202310807560.7A patent/CN116899122B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204379912U (en) * | 2013-11-20 | 2015-06-10 | 杨春梅 | Oncology microinjection apparatus |
| KR101524501B1 (en) * | 2013-11-25 | 2015-06-01 | 김동주 | Controlling apparatus of syringe for needle biopsy |
| CN208355916U (en) * | 2017-07-17 | 2019-01-11 | 贾庆哲 | Cardio angiographic unfolder |
| CN108393210A (en) * | 2018-03-30 | 2018-08-14 | 宁波高新区新柯保汽车科技有限公司 | A kind of auto parts machinery paint spraying apparatus |
| CN209790636U (en) * | 2018-09-07 | 2019-12-17 | 云南省肿瘤医院 | Tumor positioning and marking device |
| CN211751534U (en) * | 2019-04-16 | 2020-10-27 | 任林 | Department of neurology doctor uses autoinjector |
| CN213251247U (en) * | 2020-06-12 | 2021-05-25 | 东营市人民医院 | Dispensing device for oncology nursing |
| CN214969109U (en) * | 2021-02-03 | 2021-12-03 | 福建省漳州市医院 | Proportioning machine for medical infusion |
| CN217566785U (en) * | 2021-05-24 | 2022-10-14 | 北京思瑞医疗诊所有限公司 | Acupuncture point injection device |
| CN113521449A (en) * | 2021-08-09 | 2021-10-22 | 山东第一医科大学附属肿瘤医院(山东省肿瘤防治研究院、山东省肿瘤医院) | Thermostatic inhibitor injection equipment for tumor immunotherapy and implementation method thereof |
| CN217772579U (en) * | 2022-06-09 | 2022-11-11 | 唐彩霞 | Poultry animal doctor uses immunity injection device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116899122A (en) | 2023-10-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111603239B (en) | Microwave device for tumor ablation treatment | |
| CN116899122B (en) | Tumor tissue fluorescence labeling method and system | |
| CN206631871U (en) | A kind of stepless electronics ultraviolet curing machine of catheter superslide hydrophilic coating | |
| WO2006031515A2 (en) | Integrated fluid pump for use in an x-ray tube | |
| CN104771202B (en) | Grinding temperature on-line detection and nano fluid phase-change heat type grinding device | |
| CN220703705U (en) | Fungus liquid pot for fermented feed | |
| CN210303648U (en) | A apparatus for producing for graphite alkene | |
| CN209808414U (en) | Novel biopsy needle suitable for cutting of solid lesion tissue | |
| CN216621906U (en) | Urological department secretion sample preparation equipment | |
| CN115005972B (en) | Prevent repeatedly used's microwave ablation needle | |
| CN1309347C (en) | CT apparatus with radiating system | |
| CN221671739U (en) | Radioactive medical ray protection equipment | |
| CN202979445U (en) | Integrated flying spot X-ray machine | |
| CN208990027U (en) | Dept. of radiology's injection device based on long-range isolation injection | |
| CN221383597U (en) | Medical intervention radiography adjusting device | |
| CN211634646U (en) | Clinical radiography device of high dominance cardiovascular internal medicine | |
| CN218164026U (en) | Oxygen supply device for fish and shrimp culture | |
| CN220310484U (en) | Endocrinology spot check device | |
| CN213432315U (en) | Defoaming device for high-pressure radiography injection without needle cylinder | |
| CN209372823U (en) | A kind of organic carbon analyzer | |
| CN211562920U (en) | Many test tubes stir photochemical reaction device simultaneously | |
| CN215080217U (en) | Chicken bacterin injection auxiliary device that animal doctor used | |
| CN213504151U (en) | Waste collection device for tumor radiotherapy | |
| CN221332276U (en) | Tracheal storage device for oxygen tank | |
| CN217794152U (en) | Ultrasonic imaging probe convenient to clean |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |