CN116869522A - Wearable patch capable of measuring sweat rate and marker concentration of single sweat gland - Google Patents
Wearable patch capable of measuring sweat rate and marker concentration of single sweat gland Download PDFInfo
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- CN116869522A CN116869522A CN202310752050.4A CN202310752050A CN116869522A CN 116869522 A CN116869522 A CN 116869522A CN 202310752050 A CN202310752050 A CN 202310752050A CN 116869522 A CN116869522 A CN 116869522A
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- 210000000106 sweat gland Anatomy 0.000 title claims abstract description 72
- 239000003550 marker Substances 0.000 title claims abstract description 52
- 238000001514 detection method Methods 0.000 claims description 9
- 239000002699 waste material Substances 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 4
- 238000005259 measurement Methods 0.000 description 12
- 230000008859 change Effects 0.000 description 7
- 230000036541 health Effects 0.000 description 7
- 238000007599 discharging Methods 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 4
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- 238000000034 method Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
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- 150000001413 amino acids Chemical class 0.000 description 2
- 239000000090 biomarker Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
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- 239000008103 glucose Substances 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
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- 235000015097 nutrients Nutrition 0.000 description 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 1
- -1 polydimethylsiloxane Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/14517—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for sweat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
- A61B5/4261—Evaluating exocrine secretion production
- A61B5/4266—Evaluating exocrine secretion production sweat secretion
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physiology (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Abstract
The invention discloses a wearable patch capable of measuring sweat rate and marker concentration of a single sweat gland, wherein a plurality of sweat collecting and detecting channel units which are mutually independent are arranged on the wearable patch, each sweat collecting and detecting channel unit comprises a sweat collecting cavity and a sweat flowing micro-channel communicated with the sweat collecting cavity, and a sweat rate sensor and a marker concentration sensor are arranged in the sweat flowing micro-channel. The number of sweat collecting cavities and the bottom opening area of the sweat collecting cavities on the wearable patch are designed according to sweat gland density in a target skin area to be detected and based on the poisson distribution rule, and when the wearable patch is attached to the target skin area, the wearable patch can effectively ensure that the sweat collecting cavities only containing single sweat glands exist on the wearable patch, so that the sweat rate and the marker concentration of the single sweat glands can be measured.
Description
Technical Field
The invention belongs to the technical field of sweat detection, and particularly relates to a wearable patch capable of measuring sweat rate and marker concentration of a single sweat gland.
Background
Sweat contains various biomarkers which are equivalent to blood and are related to human health conditions, such as electrolytes, metabolites, amino acids, proteins, hormones and the like, and researchers can achieve the purpose of noninvasively, real-time and continuously collecting and analyzing the human health conditions on a ground line through detecting sweat, so that sweat sensing has extremely high value in the aspects of motion monitoring, disease diagnosis, telemedicine and the like.
In addition to being affected by the health condition of the human body, the sweat components and content discharged by the individual in the same state are significantly affected by the sweat rate of the individual sweat glands. For example, the concentration of sodium and chloride ions in human sweat increases with increasing sweat rate, the concentration of potassium and calcium ions decreases with increasing sweat rate, the pH is acidic (pH 3.5-6.0) at low sweat rate, the sweat pH is slightly alkaline (pH 7.0-8.5) at Gao Han, the lactic acid and urea concentrations are higher at low sweat rate, gradually decreases with increasing sweat rate, and so on. Therefore, when the concentration of the biomarker in sweat is detected, the sweat rate of a single sweat gland which discharges sweat is required to be synchronously measured, and the measurement result of the concentration of the marker is corrected by using the sweat rate, so that the measurement result has comparability, and the aim of diagnosing the health of a human body by using the measurement result of sweat is fulfilled.
The sweat sample analyzed by the sweat sensing system (including the wearable sweat sensing system, the off-line measuring system and the like) at the present stage is a mixture of sweat discharged by a plurality of sweat glands in the region, rather than locking a single sweat gland to analyze the sweat discharged by the sweat sensing system. The sweat rate and the marker concentration measurement result based on the average value of a plurality of sweat glands in the region have great fluctuation in different parts of the individual body, different moments of the same part, different individuals and the like, so that people cannot construct a clear and stable marker concentration change relation curve along with the sweat rate, the measured data cannot be accurately compared, and great difficulty is brought to accurate health diagnosis based on sweat analysis.
The reasons for the above phenomena are as follows: 1. under normal conditions, sweat glands show intermittent periodic sweat discharging characteristics, the sweat discharging moments and rates of different sweat glands in a unit area are inconsistent, the concentration of markers in the sweat discharged by the sweat glands is different, however, when the sweat discharging mixtures of a plurality of sweat glands in a measuring area are measured, the average sweat discharging rate of the sweat glands and the average value of the concentration of the markers in the sweat discharged by the sweat glands are obtained, and the sweat discharging characteristics of single sweat glands cannot be accurately reflected; 2. the sweat gland density of different parts of the body has great difference, such as finger-500 pieces/cm 2, forearm-100 pieces/cm 2, forehead-200 pieces/cm 2, and the like, and the sweat rate of sweat glands of different parts has great difference, so that the concentration of markers in sweat is greatly different, and the sweat is difficult to be used for transverse and longitudinal comparison.
As previously mentioned, the composition and amount of sweat discharged by an individual in an equivalent state is determined by the rate of sweat production by individual sweat glands. The marker concentration of sweat discharged by a single sweat gland and the sweat discharge rate corresponding to the marker concentration are measured, the correlation between the marker concentration and the sweat discharge rate is constructed, the marker concentration and the sweat discharge rate are effective means for eliminating the difference between different sweat glands, the accurate change relation of the marker concentration along with the sweat discharge rate can be obtained, the measurement result is accurately compared in the transverse and longitudinal directions, and the aim of accurately diagnosing the health of a human body by utilizing the sweat is fulfilled.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a wearable patch capable of measuring the sweat rate of a single sweat gland and the concentration of a marker, and a plurality of sweat collecting and detecting channel units which are mutually independent are arranged on the wearable patch, so that the sweat rate of the single sweat gland and the concentration of the marker can be detected.
The invention is realized by the following technical scheme:
the utility model provides a can measure wearable paster of single sweat gland sweat rate and marker concentration, includes a wearable paster, is provided with a plurality of mutually independent sweat on wearable paster and gathers detection channel unit, every sweat gather detection channel unit including a sweat collection chamber and with sweat that this sweat collection chamber open-top was linked together lead to the microchannel, be provided with sweat rate sensor and marker concentration sensor in every sweat gather detection channel unit, realize the measurement to sweat rate and marker concentration in the microchannel.
In the above technical solution, the sweat-passing micro-channels are arranged in the lateral direction of the wearable patch.
In the above technical scheme, the sweat collecting cavities of the sweat collecting and detecting channel units are arranged in concentric circles, and the sweat flowing micro-channels are arranged along the radial direction of the circles.
In the above technical solution, all sweat flows through the terminal ends of the micro channels to be collected and communicated to a waste liquid collecting tank, which is preferably located at the center of the wearable patch.
In the above technical scheme, the wearable patch can be manufactured by adopting a layered structure, and comprises a bottom layer and an upper layer, wherein a plurality of sweat collecting cavities are vertically arranged on the bottom layer, a plurality of grooves corresponding to the sweat collecting cavities and 1 through hole communicated with all the grooves are arranged on the bottom surface of the upper layer, and a marker concentration sensor and a sweat rate sensor are arranged in each groove; and then the bottom surface of the upper layer is attached to the bottom layer, all sweat collecting cavities are communicated with all grooves in a one-to-one correspondence manner, at the moment, the grooves form sweat flowing micro-channels, and the through holes form the waste liquid collecting pool, so that the wearable patch is manufactured.
In the above technical scheme, the number of sweat collecting cavities and the bottom opening area of the sweat collecting cavities on the wearable patch are designed according to sweat gland density in a target skin area to be detected and based on the poisson distribution law, and the designed wearable patch can effectively ensure that the sweat collecting cavities only containing single sweat glands exist on the wearable patch when the wearable patch is attached to the target skin area, so that the sweat releasing rate and the marker concentration of the single sweat glands can be measured.
In the above-described solutions, the thickness of the sweat collecting chamber should be as small as possible, preferably within 1mm, even within 500 μm, within 100 μm, etc.
In the above technical solution, the inner diameter of the sweat collecting cavity may be of equal diameter.
In the technical scheme, the inner diameter of the sweat collecting cavity is gradually reduced from bottom to top, and the gradually reduced structure can effectively reduce the volume of the collecting cavity and accelerate the sweat filling the collecting cavity and the subsequent measurement and analysis process.
In the technical scheme, a circle of protrusions are respectively arranged on the periphery of the bottom opening of each sweat collecting cavity on the bottom surface of the wearable patch, so that different sweat collecting cavities are isolated from each other.
The invention has the advantages and beneficial effects that:
the sweat collecting and detecting device comprises a wearable patch, wherein a plurality of sweat collecting and detecting channel units which are independent of each other are arranged on the wearable patch, each sweat collecting and detecting channel unit comprises a sweat collecting cavity and a sweat flowing micro-channel communicated with the sweat collecting cavity, and a sweat rate sensor and a marker concentration sensor are arranged in the sweat flowing micro-channel. The number of sweat collecting cavities and the bottom opening area of the sweat collecting cavities on the wearable patch are designed according to sweat gland density in a target skin area to be detected and based on the poisson distribution rule, and when the wearable patch is attached to the target skin area, the wearable patch can effectively ensure that the sweat collecting cavities only containing single sweat glands exist on the wearable patch, so that the sweat rate and the marker concentration of the single sweat glands can be measured.
Drawings
Fig. 1 is a schematic structural view of a wearable patch of the present invention.
Fig. 2 is a schematic top view of a sweat acquisition detection channel unit of the wearable patch of the present invention.
Fig. 3 is a schematic side cross-sectional structural view of one sweat acquisition detection channel unit of the wearable patch of the present invention.
Fig. 4 is an image of a human target skin area taken by an infrared macro camera.
Fig. 5 is a flow chart of the invention for determining the number of sweat collecting cavities and the open area of the bottom of the sweat collecting cavities on a wearable patch based on poisson distribution principle.
Fig. 6 is a schematic illustration of the arrangement of sweat collection chambers on a wearable patch.
Fig. 7 is a cross-sectional view of the single sweat collection chamber of fig. 6.
Fig. 8 is a schematic view of a human skin surface.
Fig. 9 is a schematic view of providing a raised structure on the bottom surface of a wearable patch.
Other relevant drawings may be made by those of ordinary skill in the art from the above figures without undue burden.
Detailed Description
In order to make the person skilled in the art better understand the solution of the present invention, the following describes the solution of the present invention with reference to specific embodiments.
Example 1
A wearable patch capable of measuring sweat rate and marker concentration of single sweat gland, see fig. 1-3, comprising a wearable patch 2000, wherein a plurality of sweat collecting and detecting channel units 210 independent of each other are arranged on the wearable patch 2000, see fig. 1, and 20 sweat collecting and detecting channel units 210 are included in the embodiment. Each sweat collecting and detecting channel unit 210 comprises a sweat collecting cavity 201, a sweat flowing micro channel 202, a sweat rate sensor 204 and a marker concentration sensor 205, wherein the sweat collecting cavity 201 is a collecting inlet for sweat discharged by sweat glands 101, a bottom opening of the sweat collecting cavity 201 is communicated with the outside so as to be contacted with skin 100 in use, and a top opening of the sweat collecting cavity 201 is communicated with a starting end of the sweat flowing micro channel 202 so that collected sweat can flow into the sweat flowing micro channel 202; the sweat flow micro-channel 202 is arranged along the transverse direction of the wearable patch, and the sweat rate sensor 204 and the marker concentration sensor 205 are arranged in the sweat flow micro-channel 202, so that the sweat flow rate and the marker concentration in the sweat flow micro-channel 202 are measured.
The arrangement form of the sweat collecting and detecting channel units 210 on the wearable patch is not limited, but it is necessary to ensure mutual independence of the sweat collecting and detecting channel units 210, so that the sweat flowing micro-channels 202 do not intersect, preferably, as shown in fig. 1, the sweat collecting cavities 201 of the sweat collecting and detecting channel units 210 are arranged in concentric circles, and the sweat flowing micro-channels 202 are arranged along the radial direction of the circles; further, all sweat flows through the terminal ends of the microchannels 202 to a waste collection reservoir 206, which waste collection reservoir 206 is preferably centrally located in the wearable patch.
Further, referring to fig. 3, the wearable patch 2000 may be manufactured in a layered structure, and includes a bottom layer 2001 and an upper layer 2002, wherein 20 sweat collecting cavities 201 are vertically arranged on the bottom layer 2001, 20 grooves 2004 and 1 through hole 2003 with larger diameter and communicated with all grooves are arranged on the bottom surface of the upper layer 2002, and a marker concentration sensor 204 and a sweat rate sensor 205 are arranged in each groove 2004; then, the bottom surface of the upper layer 2002 is attached to the bottom layer 2001, and each sweat collecting cavity 201 is correspondingly communicated with each groove 2004, at this time, the grooves 2004 form the sweat flowing micro-channel, and the through holes 2003 form the waste liquid collecting pool, so that the wearable patch is manufactured.
The number of sweat collecting cavities 201 and the bottom opening area of the sweat collecting cavities 201 on the wearable patch are designed according to sweat gland density in a target skin area to be detected and based on the poisson distribution rule, and when the wearable patch is attached to the target skin area, the sweat collecting cavities only containing single sweat glands can be effectively ensured to exist on the wearable patch, so that the sweat rate and the marker concentration of the single sweat glands can be measured. The construction and design of the sweat collection cavity 201 on the wearable patch is described in detail below with reference to fig. 4-9.
As shown in fig. 4, sweat is an effective means for reducing body temperature, the sweat process makes the temperature at the sweat gland outlet lower than the surrounding skin temperature, an image of a target skin area of a human body is taken by an infrared macro camera, and points in the image with lower temperature than the surrounding area can be identified by an image processor, so that sweat glands 301 'and surrounding skin 302' of the target skin area are identified, and sweat gland density of the target skin area is calculated.
Next, based on the poisson distribution principle, the number of sweat collecting cavities 201 on the wearable patch and the opening area where the sweat collecting cavities 201 contact the skin are determined according to the obtained sweat gland density of the target skin area.
Let P be the poisson distribution of n sweat glands in a single sweat collecting chamber n Is the number n of sweat glands actually contained therein and the average sweat gland number contained therein<n>Is a function of:
according to the procedure shown in FIG. 5, the bottom opening area S (mm) of the sweat collecting chamber where it contacts the skin is set 2 ) Sweat gland density a (root/mm) based on the target skin region obtained in step 2 2 ) Calculating the average number of sweat glands in a single sweat collecting cavity<n>，<n>= a.S, and calculating the probability P of sweat gland contained n (such as 0, 1, 2, etc.) sweat glands in the sweat collecting cavity by applying poisson distribution principle shown in formula (1) n (namely, the distribution law of sweat glands, the probability that the number of sweat collecting cavities containing sweat glands with different numbers of 0, 1, 2 and the like in the total number of sweat collecting cavities on the wearable patch shows the Poisson distribution) is R, namely P, according to the probability that all N sweat collecting cavities in the set wearable patch contain 0 sweat glands 0 N =r, the number of sweat collection chambers required can be calculated. Wherein the probability R that all N sweat collecting chambers contain 0 sweat glands can be set to a minimum probability value (e.g., 0.1%, 0.5%, 1%, etc., preferably less than 5% or even 1%); the probability that all sweat collecting cavities do not contain sweat glands will only be the minimum probability value set, wherein the probability of having sweat collecting cavities containing single sweat glands will be extremely large, thereby effectively ensuring that sweat collecting cavities containing only single sweat glands exist on the wearable patch.
Because of the small amount of perspiration of individual sweat glands, the height of the sweat collecting chamber 201 should be as small as possible, preferably within 1mm, even within 500 μm, within 100 μm, etc., to achieve the objective of rapid analysis.
In addition to the smaller height of the sweat collection chamber, the shape of the interior of the sweat collection chamber is the core factor affecting its volume, and the inner diameter of the sweat collection chamber may be of equal diameter, and more preferably, with reference to fig. 6 and 7, the inner diameter of the sweat collection chamber is of a gradually decreasing structure from bottom to top, which effectively reduces the volume of the collection chamber, and accelerates sweat filling the collection chamber into the sweat flow-through microchannel 202 for measurement analysis.
As shown in fig. 8, the skin surface is not absolutely flat but exhibits a rugged feature, and when the surface of the wearable patch in contact with the skin surface is in a flat state except for the opening of the sweat collecting cavity, there may be a gap between the skin and the patch due to the rugged feature of the skin, thereby causing the different collecting cavities to communicate with each other, so that sweat collected in a specific collecting cavity may originate from an area outside the collecting cavity, thereby affecting the accuracy of the measurement result.
In order to avoid the interconnection of the different collecting cavities, referring to fig. 9, a circle of protrusions 400 are respectively disposed on the periphery of the bottom opening of each sweat collecting cavity on the bottom surface (i.e. the surface contacting with the skin) of the wearable patch, so that the inner space enclosed by each circle of protrusions 400 and the space between each circle of protrusions 400 form a groove 401, and the groove structure can accommodate sweat discharged from the protruding skin and sweat glands at corresponding positions, thereby isolating the sweat collecting cavities from each other. Since the skin surface relief may be up to more than 100 μm, the height of the protrusions 400 is preferably comparable to or slightly larger than the skin surface relief, such as 100 μm, 150 μm or even more than 200 μm. Of course, the skin surface is elastic and compressible, and the wearable patch is typically made of a soft material, such as polydimethylsiloxane PDMS, so the raised structures are not necessarily designed to be more rough than the skin surface.
Example two
In terms of sweat rate sensors and marker concentration sensors, sweat rate sensors may be, but are not limited to, flow sensors based on the following measurement principles. 1. Principle of calorimetric heating: measuring the change condition of temperature along with the flow rate through the front temperature sensor, the rear temperature sensor and a heating element; 2: principle of electricity: the sensors of capacitance, conductance, resistance and the like measure the change condition of corresponding electrical parameters when sweat passes or not; 3. principle of differential pressure: by measuring the pressure change condition in the flow channel when sweat passes through; 4. principle of ultrasonic wave: whether sweat passes or not causes the change of ultrasonic signals; 5. optical principle: the principle that sweat passes through to cause a change in optical signals, etc.
In terms of marker concentration sensor, sweat contains 1.Na + 、K + 、Cl - A plurality of electrolytes; 2. glucose, lactic acid, uric acid and other metabolismA product; 3. cortisol and other human hormones; 4. vitamins and other nutrients; 5. health markers such as amino acids, proteins, cytokines, etc.; 6. alcohol, drugs, and other foreign substances. The marker concentration sensor may be, but is not limited to, the following category of sensors: 1. electrochemical sensors such as potential type, current type and conductivity type, field effect transistor type sensors, optical sensors, photoelectric sensors, piezoelectric sensors, and the like.
Each sweat flow microchannel 202 contains a set of sweat rate sensors and a set of marker concentration sensors, however, when more than one marker species is measured, a single sweat flow microchannel 202 may contain two or more sets of marker concentration sensors therein, and even if a single marker concentration is measured, two or more sets of marker concentration sensors and sweat rate sensors may be integrated within sweat flow microchannel 202.
In addition, the sweat rate sensor and the marker concentration sensor are preferably integrated within the sweat flow-through microchannel 202, although they may not be integrated within the microchannel as long as the sensor is capable of measuring each microchannel independently.
The proposed simultaneous measurement of sweat rate and marker concentration for individual sweat glands requires that sweat discharged from sweat glands within each sweat collection chamber be measured within a sweat flow microchannel 202 connected to itself, with sweat in different collection chambers not being interconnected until the measurement is completed. Any rate and marker concentration sensing scheme that meets such a need may suffice for the present invention.
The foregoing has described exemplary embodiments of the invention, it being understood that any simple variations, modifications, or other equivalent arrangements which would not unduly obscure the invention may be made by those skilled in the art without departing from the spirit of the invention.
Claims (10)
1. A wearable patch capable of measuring sweat rate and marker concentration of a single sweat gland, characterized by: including a wearable paster, be provided with a plurality of mutually independent sweat on the wearable paster and gather detection channel unit, every sweat gathers detection channel unit and includes a sweat collection chamber and with sweat that this sweat collection chamber open-top communicates logical microchannel, is provided with sweat rate sensor and marker concentration sensor in every sweat gathers detection channel unit.
2. The wearable patch capable of measuring sweat rate and marker concentration of individual sweat glands according to claim 1, wherein: sweat-circulating microchannels are arranged in the lateral direction of the wearable patch.
3. The wearable patch capable of measuring sweat rate and marker concentration of individual sweat glands according to claim 1, wherein: sweat collecting cavities of the sweat collecting and detecting channel units are arranged in concentric circles, and sweat flowing micro-channels are arranged along the radial direction of the circles.
4. The wearable patch capable of measuring sweat rate and marker concentration of individual sweat glands according to claim 1, wherein: all sweat flows through the terminal ends of the microchannels to a waste collection reservoir on the wearable patch.
5. The wearable patch capable of measuring sweat rate and marker concentration of individual sweat glands according to claim 1, wherein: the wearable patch can be manufactured by adopting a layered structure and comprises a bottom layer and an upper layer, wherein a plurality of sweat collecting cavities are vertically arranged on the bottom layer, a plurality of grooves corresponding to the sweat collecting cavities and 1 through hole communicated with all the grooves are arranged on the bottom surface of the upper layer, and a marker concentration sensor and a sweat rate sensor are arranged in each groove; and then the bottom surface of the upper layer is attached to the bottom layer, all sweat collecting cavities are communicated with all grooves in a one-to-one correspondence manner, at the moment, the grooves form sweat flowing micro-channels, and the through holes form the waste liquid collecting pool.
6. The wearable patch capable of measuring sweat rate and marker concentration of individual sweat glands according to claim 1, wherein: the number of sweat collecting cavities and the bottom opening area of the sweat collecting cavities on the wearable patch are designed according to sweat gland density in a target skin area to be detected and based on the poisson distribution, and when the wearable patch is attached to the target skin area, the sweat collecting cavities only containing single sweat glands can be effectively guaranteed to exist on the wearable patch.
7. The wearable patch capable of measuring sweat rate and marker concentration of individual sweat glands according to claim 1, wherein: the sweat collecting cavity has a thickness of 10 μm-1mm.
8. The wearable patch capable of measuring sweat rate and marker concentration of individual sweat glands according to claim 1, wherein: the inner diameter of the sweat collecting cavity is of equal diameter.
9. The wearable patch capable of measuring sweat rate and marker concentration of individual sweat glands according to claim 1, wherein: the inner diameter of the sweat collecting cavity is gradually reduced from bottom to top.
10. The wearable patch capable of measuring sweat rate and marker concentration of individual sweat glands according to claim 1, wherein: a circle of bulges are respectively arranged on the periphery of the bottom opening of each sweat collecting cavity on the bottom surface of the wearable patch, so that different sweat collecting cavities are isolated from each other.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310752050.4A CN116869522A (en) | 2023-06-25 | 2023-06-25 | Wearable patch capable of measuring sweat rate and marker concentration of single sweat gland |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310752050.4A CN116869522A (en) | 2023-06-25 | 2023-06-25 | Wearable patch capable of measuring sweat rate and marker concentration of single sweat gland |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116869522A true CN116869522A (en) | 2023-10-13 |
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ID=88265277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310752050.4A Pending CN116869522A (en) | 2023-06-25 | 2023-06-25 | Wearable patch capable of measuring sweat rate and marker concentration of single sweat gland |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116869522A (en) |
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2023
- 2023-06-25 CN CN202310752050.4A patent/CN116869522A/en active Pending
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